ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chaperone-mediated protein transport (GO:0072321)	8.91461713
2	ribosomal small subunit biogenesis (GO:0042274)	8.20551878
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	7.72033057
4	ATP synthesis coupled proton transport (GO:0015986)	7.72033057
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	7.39977006
6	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	6.38857228
7	pseudouridine synthesis (GO:0001522)	6.30332775
8	respiratory electron transport chain (GO:0022904)	6.18561667
9	viral transcription (GO:0019083)	6.05325860
10	electron transport chain (GO:0022900)	6.04199864
11	translational termination (GO:0006415)	5.79516542
12	ribosomal small subunit assembly (GO:0000028)	5.67152167
13	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.38443721
14	maturation of SSU-rRNA (GO:0030490)	5.38340870
15	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.28501637
16	cotranslational protein targeting to membrane (GO:0006613)	5.26342978
17	protein targeting to ER (GO:0045047)	5.26094767
18	peptidyl-histidine modification (GO:0018202)	5.14476199
19	translational elongation (GO:0006414)	5.12609211
20	respiratory chain complex IV assembly (GO:0008535)	5.02070402
21	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.99829859
22	protein localization to endoplasmic reticulum (GO:0070972)	4.96754996
23	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.84997373
24	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.84997373
25	NADH dehydrogenase complex assembly (GO:0010257)	4.84997373
26	DNA deamination (GO:0045006)	4.72375378
27	translation (GO:0006412)	4.70537906
28	protein complex biogenesis (GO:0070271)	4.64529342
29	mitochondrial respiratory chain complex assembly (GO:0033108)	4.64287166
30	protein targeting to mitochondrion (GO:0006626)	4.57467467
31	proteasome assembly (GO:0043248)	4.54519528
32	ATP biosynthetic process (GO:0006754)	4.49753926
33	viral life cycle (GO:0019058)	4.44977914
34	cellular protein complex disassembly (GO:0043624)	4.43931748
35	protein neddylation (GO:0045116)	4.43093206
36	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	4.36512871
37	purine nucleoside triphosphate biosynthetic process (GO:0009145)	4.35706984
38	cytochrome complex assembly (GO:0017004)	4.30655717
39	purine nucleotide salvage (GO:0032261)	4.30096196
40	ribonucleoprotein complex biogenesis (GO:0022613)	4.29925259
41	translational initiation (GO:0006413)	4.25931543
42	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.21050545
43	establishment of protein localization to mitochondrion (GO:0072655)	4.19712458
44	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.16011370
45	ribonucleoside triphosphate biosynthetic process (GO:0009201)	4.12556067
46	cellular component biogenesis (GO:0044085)	4.10443112
47	hydrogen ion transmembrane transport (GO:1902600)	3.95796578
48	GTP biosynthetic process (GO:0006183)	3.94582862
49	protein localization to mitochondrion (GO:0070585)	3.89911204
50	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.87758381
51	rRNA processing (GO:0006364)	3.73018731
52	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.72267496
53	regulation of mitochondrial translation (GO:0070129)	3.72039023
54	nucleoside triphosphate biosynthetic process (GO:0009142)	3.70676441
55	CTP biosynthetic process (GO:0006241)	3.62028766
56	CTP metabolic process (GO:0046036)	3.62028766
57	nucleotide salvage (GO:0043173)	3.60570353
58	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.59867445
59	termination of RNA polymerase III transcription (GO:0006386)	3.59867445
60	rRNA metabolic process (GO:0016072)	3.59376772
61	rRNA modification (GO:0000154)	3.58220212
62	protein complex disassembly (GO:0043241)	3.56481076
63	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.55338706
64	UTP biosynthetic process (GO:0006228)	3.53307373
65	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.50331428
66	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.49250156
67	pyrimidine nucleotide catabolic process (GO:0006244)	3.47355395
68	mitochondrial transport (GO:0006839)	3.44526835
69	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.42754883
70	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	3.42284724
71	purine nucleoside monophosphate biosynthetic process (GO:0009127)	3.42284724
72	nucleobase biosynthetic process (GO:0046112)	3.39600413
73	proton transport (GO:0015992)	3.38139533
74	protein targeting to membrane (GO:0006612)	3.37182923
75	ribosome biogenesis (GO:0042254)	3.37180403
76	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.34027252
77	macromolecular complex disassembly (GO:0032984)	3.33225942
78	purine nucleobase biosynthetic process (GO:0009113)	3.31869888
79	hydrogen transport (GO:0006818)	3.30818261
80	ribosomal large subunit biogenesis (GO:0042273)	3.29813297
81	ribonucleoside monophosphate biosynthetic process (GO:0009156)	3.29449879
82	inner mitochondrial membrane organization (GO:0007007)	3.28213017
83	nucleoside monophosphate biosynthetic process (GO:0009124)	3.27218695
84	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	3.26647778
85	regulation of vitamin D biosynthetic process (GO:0060556)	3.22276897
86	guanosine-containing compound biosynthetic process (GO:1901070)	3.17743432
87	UTP metabolic process (GO:0046051)	3.17336163
88	intracellular protein transmembrane import (GO:0044743)	3.16616792
89	protein-cofactor linkage (GO:0018065)	3.14563580
90	pyrimidine nucleotide biosynthetic process (GO:0006221)	3.13019116
91	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.12819131
92	spliceosomal snRNP assembly (GO:0000387)	3.10613020
93	water-soluble vitamin biosynthetic process (GO:0042364)	3.09933816
94	oxidative phosphorylation (GO:0006119)	3.08609535
95	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.08536893
96	positive regulation of prostaglandin secretion (GO:0032308)	3.05721385
97	purine-containing compound salvage (GO:0043101)	3.03663625
98	maturation of 5.8S rRNA (GO:0000460)	2.98527329
99	mRNA catabolic process (GO:0006402)	2.97344121
100	mitochondrion morphogenesis (GO:0070584)	2.97076856

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.71070810
2	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.32404034
3	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	4.12950730
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.09887590
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.06735084
6	ETS1_20019798_ChIP-Seq_JURKAT_Human	4.05007086
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.95877860
8	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.36239839
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.34911075
10	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	3.26695688
11	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.18879825
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.15340606
13	MYC_18358816_ChIP-ChIP_MESCs_Mouse	3.07803253
14	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.99204045
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.92110881
16	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.67878664
17	ZNF263_19887448_ChIP-Seq_K562_Human	2.63834407
18	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.62261557
19	DCP1A_22483619_ChIP-Seq_HELA_Human	2.57325353
20	XRN2_22483619_ChIP-Seq_HELA_Human	2.54584335
21	FOXP3_21729870_ChIP-Seq_TREG_Human	2.48650381
22	VDR_23849224_ChIP-Seq_CD4+_Human	2.47773247
23	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.41999422
24	E2F7_22180533_ChIP-Seq_HELA_Human	2.41396040
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.39041873
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.37023197
27	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.23466044
28	GABP_19822575_ChIP-Seq_HepG2_Human	2.18177355
29	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.09453564
30	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.09338909
31	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.07180293
32	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.04144047
33	TTF2_22483619_ChIP-Seq_HELA_Human	2.01593358
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.92702920
35	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.84350281
36	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.71451293
37	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.70624370
38	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.67708412
39	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.66285654
40	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.64995956
41	MYC_18940864_ChIP-ChIP_HL60_Human	1.63633986
42	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.60996393
43	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.58910921
44	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.55987919
45	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.52347755
46	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.46540019
47	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.44398066
48	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.42827601
49	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.41342381
50	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.36386941
51	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.34963448
52	KDM5A_27292631_Chip-Seq_BREAST_Human	1.33987711
53	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.31480529
54	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.31107133
55	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.29217504
56	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.27189075
57	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.26679307
58	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.24918989
59	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.23306265
60	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.22201999
61	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.13987732
62	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.12415100
63	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.09214423
64	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.09143690
65	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.08723380
66	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.07800087
67	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.06594502
68	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.02868841
69	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.01769807
70	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.00013410
71	STAT1_20625510_ChIP-Seq_HELA_Human	0.96097828
72	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.95099878
73	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.91632616
74	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.91344786
75	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.91343527
76	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.90825641
77	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.90344513
78	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.86491557
79	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.86032563
80	SA1_27219007_Chip-Seq_Bcells_Human	0.84454505
81	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.82186192
82	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.81738307
83	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.81208720
84	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.80989449
85	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.80744291
86	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.80469174
87	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.80434092
88	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.80434092
89	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.80434092
90	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.79810906
91	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.77772441
92	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.77283913
93	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.74791167
94	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.74643141
95	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.74498508
96	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.74070357
97	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.72726966
98	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.72664941
99	TFEB_21752829_ChIP-Seq_HELA_Human	0.71096101
100	TAF2_19829295_ChIP-Seq_ESCs_Human	0.70715944

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.75038983
2	MP0002163_abnormal_gland_morphology	4.70731595
3	MP0003806_abnormal_nucleotide_metabolis	3.07586669
4	MP0005379_endocrine/exocrine_gland_phen	3.06474299
5	MP0003693_abnormal_embryo_hatching	3.01768863
6	MP0005408_hypopigmentation	2.77743474
7	MP0008007_abnormal_cellular_replicative	2.69558722
8	MP0005646_abnormal_pituitary_gland	2.64417188
9	MP0006036_abnormal_mitochondrial_physio	2.60703271
10	MP0002837_dystrophic_cardiac_calcinosis	2.52781696
11	MP0003195_calcinosis	2.50024152
12	MP0003123_paternal_imprinting	2.46659418
13	MP0003303_peritoneal_inflammation	2.36784318
14	MP0003186_abnormal_redox_activity	2.36480847
15	MP0008058_abnormal_DNA_repair	2.25426553
16	MP0001919_abnormal_reproductive_system	2.22748796
17	MP0006292_abnormal_olfactory_placode	2.21021025
18	MP0004858_abnormal_nervous_system	2.14601055
19	MP0003111_abnormal_nucleus_morphology	2.11068900
20	MP0000678_abnormal_parathyroid_gland	2.10021579
21	MP0002148_abnormal_hypersensitivity_rea	1.98451674
22	MP0004957_abnormal_blastocyst_morpholog	1.93158245
23	MP0009333_abnormal_splenocyte_physiolog	1.92371883
24	MP0003786_premature_aging	1.90519409
25	MP0001764_abnormal_homeostasis	1.86482467
26	MP0008932_abnormal_embryonic_tissue	1.61842590
27	MP0005671_abnormal_response_to	1.56899824
28	MP0005389_reproductive_system_phenotype	1.55632056
29	MP0003941_abnormal_skin_development	1.54690467
30	MP0005647_abnormal_sex_gland	1.47465993
31	MP0003646_muscle_fatigue	1.45106065
32	MP0003718_maternal_effect	1.42885091
33	MP0009785_altered_susceptibility_to	1.40339876
34	MP0003763_abnormal_thymus_physiology	1.39090491
35	MP0010307_abnormal_tumor_latency	1.34383365
36	MP0003077_abnormal_cell_cycle	1.34296134
37	MP0000566_synostosis	1.29554142
38	MP0002132_abnormal_respiratory_system	1.29522606
39	MP0010094_abnormal_chromosome_stability	1.29309462
40	MP0001348_abnormal_lacrimal_gland	1.27146865
41	MP0001835_abnormal_antigen_presentation	1.26791781
42	MP0002653_abnormal_ependyma_morphology	1.25258370
43	MP0000049_abnormal_middle_ear	1.23078744
44	MP0002095_abnormal_skin_pigmentation	1.22922571
45	MP0000343_altered_response_to	1.18567465
46	MP0001790_abnormal_immune_system	1.18014960
47	MP0005387_immune_system_phenotype	1.18014960
48	MP0000750_abnormal_muscle_regeneration	1.12545484
49	MP0002160_abnormal_reproductive_system	1.10118547
50	MP0006082_CNS_inflammation	1.09733251
51	MP0002277_abnormal_respiratory_mucosa	1.09035811
52	MP0002452_abnormal_antigen_presenting	1.08288479
53	MP0001800_abnormal_humoral_immune	1.04426875
54	MP0002138_abnormal_hepatobiliary_system	1.04287895
55	MP0000371_diluted_coat_color	1.03445727
56	MP0005000_abnormal_immune_tolerance	1.02982411
57	MP0005636_abnormal_mineral_homeostasis	1.02414698
58	MP0006035_abnormal_mitochondrial_morpho	1.00161558
59	MP0009046_muscle_twitch	0.99366917
60	MP0002139_abnormal_hepatobiliary_system	0.98491567
61	MP0002736_abnormal_nociception_after	0.98433942
62	MP0002723_abnormal_immune_serum	0.98073368
63	MP0008469_abnormal_protein_level	0.97961255
64	MP0005332_abnormal_amino_acid	0.97320878
65	MP0000703_abnormal_thymus_morphology	0.97044885
66	MP0000350_abnormal_cell_proliferation	0.94790039
67	MP0001819_abnormal_immune_cell	0.91264371
68	MP0002420_abnormal_adaptive_immunity	0.90029838
69	MP0001727_abnormal_embryo_implantation	0.89909357
70	MP0005025_abnormal_response_to	0.89138996
71	MP0001188_hyperpigmentation	0.88164854
72	MP0009764_decreased_sensitivity_to	0.87508761
73	MP0004145_abnormal_muscle_electrophysio	0.86889093
74	MP0005075_abnormal_melanosome_morpholog	0.86316639
75	MP0002938_white_spotting	0.86272525
76	MP0004147_increased_porphyrin_level	0.86268939
77	MP0003183_abnormal_peptide_metabolism	0.85382201
78	MP0005266_abnormal_metabolism	0.84725473
79	MP0003075_altered_response_to	0.84548994
80	MP0001845_abnormal_inflammatory_respons	0.81957141
81	MP0000313_abnormal_cell_death	0.81085498
82	MP0008875_abnormal_xenobiotic_pharmacok	0.79941001
83	MP0005410_abnormal_fertilization	0.79747154
84	MP0005167_abnormal_blood-brain_barrier	0.79490688
85	MP0001529_abnormal_vocalization	0.78555716
86	MP0001881_abnormal_mammary_gland	0.76788220
87	MP0004142_abnormal_muscle_tone	0.74174371
88	MP0009765_abnormal_xenobiotic_induced	0.73442872
89	MP0002419_abnormal_innate_immunity	0.72567293
90	MP0004019_abnormal_vitamin_homeostasis	0.72156639
91	MP0002398_abnormal_bone_marrow	0.70281833
92	MP0000685_abnormal_immune_system	0.69934276
93	MP0001186_pigmentation_phenotype	0.68198512
94	MP0009763_increased_sensitivity_to	0.67573067
95	MP0005187_abnormal_penis_morphology	0.67166636
96	MP0001485_abnormal_pinna_reflex	0.67024261
97	MP0000716_abnormal_immune_system	0.65600927
98	MP0002429_abnormal_blood_cell	0.65031036
99	MP0008057_abnormal_DNA_replication	0.64753274
100	MP0000858_altered_metastatic_potential	0.64494444

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	6.30928332
2	Abnormal mitochondria in muscle tissue (HP:0008316)	6.13000146
3	Mitochondrial inheritance (HP:0001427)	5.74659296
4	Acute encephalopathy (HP:0006846)	5.41972783
5	Increased CSF lactate (HP:0002490)	5.23430605
6	Progressive macrocephaly (HP:0004481)	5.19773887
7	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	5.19073061
8	Decreased activity of mitochondrial respiratory chain (HP:0008972)	5.19073061
9	Increased hepatocellular lipid droplets (HP:0006565)	4.96854380
10	3-Methylglutaconic aciduria (HP:0003535)	4.95596176
11	Increased intramyocellular lipid droplets (HP:0012240)	4.93218898
12	Hepatocellular necrosis (HP:0001404)	4.53218488
13	Renal Fanconi syndrome (HP:0001994)	4.47948652
14	Lipid accumulation in hepatocytes (HP:0006561)	4.30583948
15	Hepatic necrosis (HP:0002605)	4.29084588
16	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	4.17527716
17	Increased muscle lipid content (HP:0009058)	4.07249842
18	Cerebral edema (HP:0002181)	3.93016048
19	Increased serum lactate (HP:0002151)	3.80918504
20	Lactic acidosis (HP:0003128)	3.72139106
21	Exertional dyspnea (HP:0002875)	3.63936154
22	Respiratory failure (HP:0002878)	3.58374222
23	Macrocytic anemia (HP:0001972)	3.56866522
24	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.56655295
25	Abnormal number of erythroid precursors (HP:0012131)	3.27703683
26	Testicular atrophy (HP:0000029)	3.24251133
27	Respiratory difficulties (HP:0002880)	3.23898918
28	Cleft eyelid (HP:0000625)	3.15929899
29	Abnormality of alanine metabolism (HP:0010916)	3.15826530
30	Hyperalaninemia (HP:0003348)	3.15826530
31	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.15826530
32	B lymphocytopenia (HP:0010976)	3.15801895
33	Exercise intolerance (HP:0003546)	3.10965423
34	Aplastic anemia (HP:0001915)	3.08979512
35	Reticulocytopenia (HP:0001896)	3.07096406
36	Abnormality of cells of the erythroid lineage (HP:0012130)	3.03585409
37	Abnormality of B cell number (HP:0010975)	2.99082831
38	Leukodystrophy (HP:0002415)	2.65338136
39	Pallor (HP:0000980)	2.54941130
40	Hyperphosphaturia (HP:0003109)	2.53526601
41	Lethargy (HP:0001254)	2.51266479
42	Optic disc pallor (HP:0000543)	2.44310220
43	CNS demyelination (HP:0007305)	2.40426567
44	Abnormality of renal resorption (HP:0011038)	2.37509779
45	Hypoplasia of the radius (HP:0002984)	2.35590011
46	Neoplasm of head and neck (HP:0012288)	2.29681193
47	Esophageal neoplasm (HP:0100751)	2.29681193
48	Stomatitis (HP:0010280)	2.28188672
49	Pancytopenia (HP:0001876)	2.21001698
50	Retrobulbar optic neuritis (HP:0100654)	2.16882904
51	Optic neuritis (HP:0100653)	2.16882904
52	Generalized aminoaciduria (HP:0002909)	2.15907851
53	IgM deficiency (HP:0002850)	2.14954269
54	Abnormality of urine glucose concentration (HP:0011016)	2.14269700
55	Glycosuria (HP:0003076)	2.14269700
56	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.10896503
57	Parakeratosis (HP:0001036)	2.05450338
58	Progressive microcephaly (HP:0000253)	2.04110511
59	Gout (HP:0001997)	2.03763010
60	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.00748400
61	Microretrognathia (HP:0000308)	1.99935386
62	Increased serum pyruvate (HP:0003542)	1.99336255
63	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.96958793
64	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.96675248
65	Nausea (HP:0002018)	1.96279003
66	Degeneration of anterior horn cells (HP:0002398)	1.93366695
67	Abnormality of the anterior horn cell (HP:0006802)	1.93366695
68	Abnormality of liposaccharide metabolism (HP:0010968)	1.93302397
69	Abnormality of glycosphingolipid metabolism (HP:0004343)	1.93302397
70	Abnormality of glycolipid metabolism (HP:0010969)	1.93302397
71	Poor head control (HP:0002421)	1.90985812
72	Abnormal urine phosphate concentration (HP:0012599)	1.90108732
73	Oral leukoplakia (HP:0002745)	1.89613652
74	Abnormality of T cell physiology (HP:0011840)	1.86122159
75	Sparse eyelashes (HP:0000653)	1.85739922
76	Triphalangeal thumb (HP:0001199)	1.83547881
77	Congenital stationary night blindness (HP:0007642)	1.81587870
78	Emotional lability (HP:0000712)	1.80941134
79	Methylmalonic aciduria (HP:0012120)	1.78793195
80	Short middle phalanx of the 5th finger (HP:0004220)	1.78495072
81	Constricted visual fields (HP:0001133)	1.78192885
82	Absent thumb (HP:0009777)	1.74692377
83	Orchitis (HP:0100796)	1.73878996
84	Renal cortical cysts (HP:0000803)	1.73302305
85	Renal tubular dysfunction (HP:0000124)	1.71000534
86	Blindness (HP:0000618)	1.70425148
87	Delayed epiphyseal ossification (HP:0002663)	1.69261377
88	Hypoplastic pelvis (HP:0008839)	1.68395714
89	Paralysis (HP:0003470)	1.67275795
90	Meckel diverticulum (HP:0002245)	1.66315981
91	Aplasia/hypoplasia of the uterus (HP:0008684)	1.65465516
92	Gastrointestinal stroma tumor (HP:0100723)	1.64019505
93	IgG deficiency (HP:0004315)	1.63537478
94	Absent forearm bone (HP:0003953)	1.63186328
95	Aplasia involving forearm bones (HP:0009822)	1.63186328
96	Hyperglycinemia (HP:0002154)	1.60941708
97	Basal ganglia calcification (HP:0002135)	1.59659341
98	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.59351873
99	Ragged-red muscle fibers (HP:0003200)	1.58970987
100	Gliosis (HP:0002171)	1.56195067

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	7.66734255
2	PBK	4.11275336
3	TXK	3.32348082
4	BUB1	3.22062499
5	PDK2	2.88725490
6	BCKDK	2.88281442
7	IRAK3	2.79017636
8	EIF2AK1	2.24321100
9	ARAF	2.23037860
10	VRK2	2.10131673
11	ADRBK2	1.89805073
12	MAP3K9	1.70498460
13	TYK2	1.61776333
14	STK16	1.60097217
15	ZAK	1.58821631
16	ABL2	1.57307891
17	GRK1	1.56811122
18	CDC7	1.54952982
19	SRPK1	1.54231188
20	IKBKE	1.53841836
21	BRAF	1.49758830
22	MAP4K1	1.48525070
23	WNK4	1.43400934
24	MAP3K13	1.42345746
25	DYRK2	1.33837047
26	PIM2	1.33476399
27	JAK3	1.27837376
28	NME1	1.26394435
29	IKBKB	1.23170994
30	NEK1	1.22608746
31	GRK7	1.20012767
32	STK4	1.14842961
33	LRRK2	1.12395401
34	NTRK3	1.11825210
35	MOS	1.06276256
36	TAOK2	1.04353753
37	MAPK11	1.03681553
38	TLK1	0.99949284
39	RIPK4	0.92359191
40	CSNK2A1	0.83744655
41	CSNK2A2	0.82610911
42	PRKCI	0.81901718
43	PRKCG	0.81684867
44	CHEK2	0.80573786
45	ATR	0.80384863
46	PLK1	0.78842062
47	ILK	0.77882075
48	PAK1	0.77476630
49	RPS6KA5	0.76733689
50	CSK	0.75876698
51	EIF2AK3	0.75281605
52	DYRK3	0.74888966
53	MATK	0.72596983
54	MAP3K8	0.71299000
55	CAMKK2	0.68522944
56	WNK3	0.68308744
57	TBK1	0.67175481
58	CDK4	0.66375097
59	PIM1	0.65958529
60	VRK1	0.64821591
61	TEC	0.62419528
62	MAP3K11	0.58979483
63	RPS6KA4	0.57061493
64	CHEK1	0.55855168
65	AURKA	0.55305324
66	MST4	0.54771494
67	MAP2K6	0.54724188
68	TAOK3	0.52836582
69	TNIK	0.52262914
70	AURKB	0.52164259
71	SYK	0.52035334
72	NUAK1	0.51041006
73	ITK	0.50001361
74	TSSK6	0.49418833
75	CSNK1G1	0.45602811
76	NLK	0.45516574
77	SCYL2	0.45387161
78	PLK3	0.43947507
79	PRKG2	0.42933596
80	TIE1	0.42727538
81	NEK9	0.41204989
82	CSNK1G3	0.40818266
83	BTK	0.38815789
84	MKNK2	0.38417633
85	PRKCD	0.37928498
86	IRAK4	0.37846262
87	CSNK1E	0.36350211
88	LCK	0.34149875
89	BMPR2	0.32535535
90	PRKACA	0.32153851
91	PRKCA	0.31935498
92	PDPK1	0.28998475
93	LYN	0.28809458
94	CSNK1A1	0.28040706
95	ALK	0.26460801
96	CAMK2G	0.26033089
97	MKNK1	0.25847690
98	INSRR	0.25564324
99	UHMK1	0.24208401
100	PLK4	0.22135401

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.01919564
2	Oxidative phosphorylation_Homo sapiens_hsa00190	5.44321481
3	Parkinsons disease_Homo sapiens_hsa05012	4.60523320
4	Huntingtons disease_Homo sapiens_hsa05016	3.24809173
5	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	3.21664821
6	Alzheimers disease_Homo sapiens_hsa05010	3.09945877
7	RNA polymerase_Homo sapiens_hsa03020	3.01534607
8	Proteasome_Homo sapiens_hsa03050	2.99037334
9	DNA replication_Homo sapiens_hsa03030	2.43377697
10	Homologous recombination_Homo sapiens_hsa03440	2.35324186
11	Protein export_Homo sapiens_hsa03060	2.22066338
12	Pyrimidine metabolism_Homo sapiens_hsa00240	2.04067720
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.03275335
14	One carbon pool by folate_Homo sapiens_hsa00670	1.92590360
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.86529757
16	Cardiac muscle contraction_Homo sapiens_hsa04260	1.82469118
17	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.82158657
18	Sulfur metabolism_Homo sapiens_hsa00920	1.80623483
19	Spliceosome_Homo sapiens_hsa03040	1.78373064
20	Mismatch repair_Homo sapiens_hsa03430	1.77945613
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.71139278
22	Sulfur relay system_Homo sapiens_hsa04122	1.63910071
23	Folate biosynthesis_Homo sapiens_hsa00790	1.53040058
24	Base excision repair_Homo sapiens_hsa03410	1.48487383
25	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.33448165
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.25786797
27	Basal transcription factors_Homo sapiens_hsa03022	1.18650339
28	Purine metabolism_Homo sapiens_hsa00230	1.17950586
29	Primary immunodeficiency_Homo sapiens_hsa05340	1.17471914
30	RNA degradation_Homo sapiens_hsa03018	1.08015714
31	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.91544865
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.91047090
33	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.87373769
34	Metabolic pathways_Homo sapiens_hsa01100	0.87057653
35	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.86802155
36	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.85703154
37	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.81578315
38	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.80694835
39	RNA transport_Homo sapiens_hsa03013	0.75695535
40	Asthma_Homo sapiens_hsa05310	0.75094148
41	Rheumatoid arthritis_Homo sapiens_hsa05323	0.74449154
42	Allograft rejection_Homo sapiens_hsa05330	0.69075683
43	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.68417303
44	Collecting duct acid secretion_Homo sapiens_hsa04966	0.68374209
45	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.65146178
46	Linoleic acid metabolism_Homo sapiens_hsa00591	0.64502200
47	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.63339807
48	Graft-versus-host disease_Homo sapiens_hsa05332	0.58955770
49	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.58384783
50	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.54180306
51	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.53577871
52	Glutathione metabolism_Homo sapiens_hsa00480	0.51730150
53	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.51417185
54	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.50287331
55	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.49863855
56	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.48293917
57	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.46112432
58	Nitrogen metabolism_Homo sapiens_hsa00910	0.45264281
59	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.44842810
60	Type I diabetes mellitus_Homo sapiens_hsa04940	0.43955036
61	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.43623812
62	Pyruvate metabolism_Homo sapiens_hsa00620	0.43048039
63	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.40705054
64	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.40586274
65	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.39467724
66	Tyrosine metabolism_Homo sapiens_hsa00350	0.38262663
67	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.38079006
68	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.37310817
69	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.36607419
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.33980831
71	Ether lipid metabolism_Homo sapiens_hsa00565	0.33875132
72	Tryptophan metabolism_Homo sapiens_hsa00380	0.33852445
73	Arginine and proline metabolism_Homo sapiens_hsa00330	0.32838207
74	African trypanosomiasis_Homo sapiens_hsa05143	0.31906770
75	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.30033343
76	Legionellosis_Homo sapiens_hsa05134	0.29160494
77	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.29050083
78	Malaria_Homo sapiens_hsa05144	0.27595867
79	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.27297399
80	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.25854026
81	Cell cycle_Homo sapiens_hsa04110	0.25396082
82	Prion diseases_Homo sapiens_hsa05020	0.24793820
83	p53 signaling pathway_Homo sapiens_hsa04115	0.24665318
84	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.24006438
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.21744720
86	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.21729625
87	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.21442193
88	Non-homologous end-joining_Homo sapiens_hsa03450	0.21120304
89	Galactose metabolism_Homo sapiens_hsa00052	0.20815820
90	Herpes simplex infection_Homo sapiens_hsa05168	0.19855411
91	Selenocompound metabolism_Homo sapiens_hsa00450	0.18411896
92	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.15145944
93	Peroxisome_Homo sapiens_hsa04146	0.13373298
94	Antigen processing and presentation_Homo sapiens_hsa04612	0.11654195
95	Fatty acid elongation_Homo sapiens_hsa00062	0.11609499
96	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.09551365
97	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.08971790
98	Chemical carcinogenesis_Homo sapiens_hsa05204	0.07707036
99	Phenylalanine metabolism_Homo sapiens_hsa00360	0.07494102
100	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.06797200

RPL23AP93

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »