ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chaperone-mediated protein transport (GO:0072321)	6.06007915
2	DNA deamination (GO:0045006)	6.01583786
3	positive regulation of defense response to virus by host (GO:0002230)	5.16244826
4	interferon-gamma production (GO:0032609)	4.81198482
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.56828041
6	leukocyte aggregation (GO:0070486)	4.48015651
7	activation of MAPKKK activity (GO:0000185)	4.34717239
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.26561187
9	ATP synthesis coupled proton transport (GO:0015986)	4.26561187
10	cellular response to interleukin-15 (GO:0071350)	4.19562049
11	GDP-mannose metabolic process (GO:0019673)	4.18325564
12	nucleoside transmembrane transport (GO:1901642)	4.07812967
13	piRNA metabolic process (GO:0034587)	4.03199902
14	positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)	3.95743091
15	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.79631446
16	ribosomal small subunit assembly (GO:0000028)	3.67977539
17	viral transcription (GO:0019083)	3.64953096
18	cytidine metabolic process (GO:0046087)	3.60765389
19	cytidine catabolic process (GO:0006216)	3.60765389
20	cytidine deamination (GO:0009972)	3.60765389
21	regulation of defense response to virus by host (GO:0050691)	3.60467628
22	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.54942164
23	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.48748569
24	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.48748569
25	nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)	3.47152469
26	mast cell activation (GO:0045576)	3.44795893
27	translational termination (GO:0006415)	3.39943706
28	translational elongation (GO:0006414)	3.39812861
29	regulation of regulatory T cell differentiation (GO:0045589)	3.33329396
30	sleep (GO:0030431)	3.28565152
31	mast cell activation involved in immune response (GO:0002279)	3.25875782
32	mast cell degranulation (GO:0043303)	3.25875782
33	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.25759815
34	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.23834413
35	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.19565596
36	response to pheromone (GO:0019236)	3.18926652
37	endoderm formation (GO:0001706)	3.17855035
38	response to interleukin-15 (GO:0070672)	3.16038405
39	mannose metabolic process (GO:0006013)	3.14887074
40	ribosomal small subunit biogenesis (GO:0042274)	3.13465817
41	glycoprotein catabolic process (GO:0006516)	3.10298958
42	positive regulation of fatty acid transport (GO:2000193)	3.05238884
43	rRNA transcription (GO:0009303)	3.04404791
44	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.03096905
45	positive regulation of T cell differentiation in thymus (GO:0033089)	3.02552234
46	regulation of T cell mediated cytotoxicity (GO:0001914)	2.99860688
47	cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)	2.97180009
48	nucleoside transport (GO:0015858)	2.97077186
49	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.96631792
50	DNA methylation involved in gamete generation (GO:0043046)	2.94567844
51	cellular response to exogenous dsRNA (GO:0071360)	2.94161765
52	positive thymic T cell selection (GO:0045059)	2.91354965
53	positive regulation of icosanoid secretion (GO:0032305)	2.91350665
54	water-soluble vitamin biosynthetic process (GO:0042364)	2.90366727
55	termination of RNA polymerase III transcription (GO:0006386)	2.90207155
56	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.90207155
57	positive regulation of signal transduction by p53 class mediator (GO:1901798)	2.89896845
58	pseudouridine synthesis (GO:0001522)	2.88986282
59	dendritic cell chemotaxis (GO:0002407)	2.85400418
60	positive regulation of gamma-delta T cell activation (GO:0046645)	2.83566305
61	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.79980590
62	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.77065344
63	protein targeting to ER (GO:0045047)	2.76630644
64	reciprocal meiotic recombination (GO:0007131)	2.72032385
65	reciprocal DNA recombination (GO:0035825)	2.72032385
66	tolerance induction (GO:0002507)	2.71174236
67	cotranslational protein targeting to membrane (GO:0006613)	2.71026979
68	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.68701836
69	behavioral response to nicotine (GO:0035095)	2.68615242
70	pantothenate metabolic process (GO:0015939)	2.68367164
71	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.68021078
72	regulation of gamma-delta T cell differentiation (GO:0045586)	2.64129825
73	negative regulation of cAMP-mediated signaling (GO:0043951)	2.61932623
74	protein localization to endoplasmic reticulum (GO:0070972)	2.59771863
75	regulation of T cell receptor signaling pathway (GO:0050856)	2.58334326
76	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.58289579
77	negative regulation of mast cell activation (GO:0033004)	2.54965308
78	viral life cycle (GO:0019058)	2.53801415
79	T cell receptor signaling pathway (GO:0050852)	2.53486190
80	fucose catabolic process (GO:0019317)	2.51595043
81	L-fucose metabolic process (GO:0042354)	2.51595043
82	L-fucose catabolic process (GO:0042355)	2.51595043
83	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.50984605
84	maturation of SSU-rRNA (GO:0030490)	2.50474746
85	regulation of mitotic spindle checkpoint (GO:1903504)	2.48217577
86	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.48217577
87	T cell migration (GO:0072678)	2.48192948
88	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.47508993
89	negative regulation of nitric oxide biosynthetic process (GO:0045019)	2.47307397
90	positive regulation of T cell mediated immunity (GO:0002711)	2.46721027
91	negative T cell selection (GO:0043383)	2.44211082
92	regulation of germinal center formation (GO:0002634)	2.42827612
93	positive regulation of T-helper 1 type immune response (GO:0002827)	2.42646067
94	cellular protein complex disassembly (GO:0043624)	2.41984828
95	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.39988620
96	indolalkylamine metabolic process (GO:0006586)	2.39836374
97	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.39347160
98	response to interferon-beta (GO:0035456)	2.39280582
99	meiotic chromosome segregation (GO:0045132)	2.38878067
100	negative regulation of cell killing (GO:0031342)	2.36619098

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.10331921
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	4.40776852
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.14074116
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.88436640
5	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.21196161
6	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.07814184
7	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.84535471
8	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.73063897
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.67654548
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.58136079
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.42774552
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.40111699
13	VDR_22108803_ChIP-Seq_LS180_Human	2.24558963
14	RUNX_20019798_ChIP-Seq_JUKART_Human	2.18868815
15	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.13046395
16	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.08821725
17	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.05010044
18	VDR_23849224_ChIP-Seq_CD4+_Human	1.96661442
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.95050637
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.94755082
21	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.87942530
22	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.87869727
23	GATA3_26560356_Chip-Seq_TH2_Human	1.84884848
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.81544373
25	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.78394474
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.76922979
27	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.75330290
28	MYB_26560356_Chip-Seq_TH2_Human	1.72577414
29	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.70138506
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.59942373
31	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.58312370
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.57628147
33	STAT1_20625510_ChIP-Seq_HELA_Human	1.52850678
34	GATA3_27048872_Chip-Seq_THYMUS_Human	1.51336681
35	AR_20517297_ChIP-Seq_VCAP_Human	1.49369955
36	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.46992250
37	E2F1_20622854_ChIP-Seq_HELA_Human	1.45578945
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.45404569
39	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.44004389
40	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.42537211
41	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.37886047
42	NANOG_20526341_ChIP-Seq_ESCs_Human	1.36726826
43	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.36242330
44	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.34926039
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.34926039
46	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.31009025
47	TAF2_19829295_ChIP-Seq_ESCs_Human	1.30812713
48	CIITA_25753668_ChIP-Seq_RAJI_Human	1.29774674
49	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.28419025
50	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.28323384
51	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.28029060
52	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.26688569
53	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.25483851
54	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.24930729
55	NCOR_22424771_ChIP-Seq_293T_Human	1.24182946
56	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.23306509
57	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.23274698
58	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.22667326
59	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.19409925
60	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.19092904
61	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.18984896
62	BCL6_27268052_Chip-Seq_Bcells_Human	1.18501034
63	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.17863796
64	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.16317739
65	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.15469613
66	MYC_18940864_ChIP-ChIP_HL60_Human	1.14871998
67	EZH2_22144423_ChIP-Seq_EOC_Human	1.14649782
68	ERA_21632823_ChIP-Seq_H3396_Human	1.13272862
69	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12970017
70	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.12482951
71	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.10825823
72	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.09136497
73	RBPJ_21746931_ChIP-Seq_IB4_Human	1.09115465
74	ELK1_19687146_ChIP-ChIP_HELA_Human	1.08051047
75	P300_27268052_Chip-Seq_Bcells_Human	1.07234568
76	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.06650817
77	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.06560500
78	GATA3_26560356_Chip-Seq_TH1_Human	1.04710484
79	CTCF_20526341_ChIP-Seq_ESCs_Human	1.04305738
80	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.03264560
81	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.02793398
82	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.02411473
83	OCT4_20526341_ChIP-Seq_ESCs_Human	1.00089559
84	SOX2_21211035_ChIP-Seq_LN229_Human	0.99815854
85	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.99452537
86	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.99255008
87	P53_21459846_ChIP-Seq_SAOS-2_Human	0.98482648
88	RAC3_21632823_ChIP-Seq_H3396_Human	0.97409697
89	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.94905228
90	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.94717754
91	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.94711770
92	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.94683374
93	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.94532580
94	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.94107825
95	SPI1_23547873_ChIP-Seq_NB4_Human	0.93565819
96	IRF1_19129219_ChIP-ChIP_H3396_Human	0.93334251
97	ERG_20517297_ChIP-Seq_VCAP_Human	0.92208436
98	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.92176588
99	PHF8_20622853_ChIP-Seq_HELA_Human	0.91743517
100	FUS_26573619_Chip-Seq_HEK293_Human	0.90761791

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.85904173
2	MP0002638_abnormal_pupillary_reflex	3.12658084
3	MP0003724_increased_susceptibility_to	2.91676939
4	MP0005623_abnormal_meninges_morphology	2.77386554
5	MP0006072_abnormal_retinal_apoptosis	2.71342555
6	MP0005360_urolithiasis	2.67402619
7	MP0001835_abnormal_antigen_presentation	2.62809852
8	MP0004147_increased_porphyrin_level	2.60885901
9	MP0000013_abnormal_adipose_tissue	2.58891890
10	MP0005000_abnormal_immune_tolerance	2.39282424
11	MP0001800_abnormal_humoral_immune	2.38937337
12	MP0003646_muscle_fatigue	2.34872110
13	MP0002148_abnormal_hypersensitivity_rea	2.25886432
14	MP0003436_decreased_susceptibility_to	2.20199158
15	MP0000685_abnormal_immune_system	2.09480618
16	MP0004947_skin_inflammation	2.01580320
17	MP0003763_abnormal_thymus_physiology	2.00405559
18	MP0002723_abnormal_immune_serum	1.94982836
19	MP0009785_altered_susceptibility_to	1.93747352
20	MP0001790_abnormal_immune_system	1.93483159
21	MP0005387_immune_system_phenotype	1.93483159
22	MP0003786_premature_aging	1.90077370
23	MP0005646_abnormal_pituitary_gland	1.89622392
24	MP0009764_decreased_sensitivity_to	1.88672667
25	MP0004043_abnormal_pH_regulation	1.86022784
26	MP0004885_abnormal_endolymph	1.85416480
27	MP0002420_abnormal_adaptive_immunity	1.80961668
28	MP0001819_abnormal_immune_cell	1.80367820
29	MP0002452_abnormal_antigen_presenting	1.79917636
30	MP0009333_abnormal_splenocyte_physiolog	1.71731659
31	MP0001986_abnormal_taste_sensitivity	1.66379024
32	MP0010155_abnormal_intestine_physiology	1.65954303
33	MP0008875_abnormal_xenobiotic_pharmacok	1.65756818
34	MP0001873_stomach_inflammation	1.63864954
35	MP0003866_abnormal_defecation	1.61846048
36	MP0005025_abnormal_response_to	1.58490793
37	MP0009379_abnormal_foot_pigmentation	1.57297853
38	MP0002876_abnormal_thyroid_physiology	1.54357348
39	MP0008872_abnormal_physiological_respon	1.50927726
40	MP0002138_abnormal_hepatobiliary_system	1.50752224
41	MP0005551_abnormal_eye_electrophysiolog	1.46969836
42	MP0000372_irregular_coat_pigmentation	1.46250096
43	MP0008775_abnormal_heart_ventricle	1.40846113
44	MP0001501_abnormal_sleep_pattern	1.36560976
45	MP0009384_cardiac_valve_regurgitation	1.33890409
46	MP0005075_abnormal_melanosome_morpholog	1.33435216
47	MP0003011_delayed_dark_adaptation	1.33021171
48	MP0002933_joint_inflammation	1.32225560
49	MP0005389_reproductive_system_phenotype	1.30259352
50	MP0000750_abnormal_muscle_regeneration	1.28923562
51	MP0002419_abnormal_innate_immunity	1.26356524
52	MP0001845_abnormal_inflammatory_respons	1.24420203
53	MP0000858_altered_metastatic_potential	1.23956172
54	MP0001533_abnormal_skeleton_physiology	1.23334210
55	MP0002398_abnormal_bone_marrow	1.20939372
56	MP0000689_abnormal_spleen_morphology	1.20810251
57	MP0000716_abnormal_immune_system	1.19407482
58	MP0002938_white_spotting	1.18674877
59	MP0005464_abnormal_platelet_physiology	1.18076375
60	MP0005253_abnormal_eye_physiology	1.15776157
61	MP0006082_CNS_inflammation	1.15443456
62	MP0001919_abnormal_reproductive_system	1.11912064
63	MP0002006_tumorigenesis	1.11318324
64	MP0002277_abnormal_respiratory_mucosa	1.09727251
65	MP0002166_altered_tumor_susceptibility	1.05750645
66	MP0002722_abnormal_immune_system	1.05090910
67	MP0008469_abnormal_protein_level	1.01357018
68	MP0002102_abnormal_ear_morphology	0.99793116
69	MP0002837_dystrophic_cardiac_calcinosis	0.98929860
70	MP0003638_abnormal_response/metabolism_	0.98480746
71	MP0002736_abnormal_nociception_after	0.97739086
72	MP0001968_abnormal_touch/_nociception	0.97262094
73	MP0002429_abnormal_blood_cell	0.96878117
74	MP0004130_abnormal_muscle_cell	0.96715529
75	MP0000465_gastrointestinal_hemorrhage	0.96253222
76	MP0001542_abnormal_bone_strength	0.95443502
77	MP0001765_abnormal_ion_homeostasis	0.93008710
78	MP0003195_calcinosis	0.89681230
79	MP0001905_abnormal_dopamine_level	0.89188522
80	MP0002160_abnormal_reproductive_system	0.88825479
81	MP0005410_abnormal_fertilization	0.87699392
82	MP0009765_abnormal_xenobiotic_induced	0.86124937
83	MP0005332_abnormal_amino_acid	0.84863577
84	MP0005174_abnormal_tail_pigmentation	0.83505865
85	MP0002019_abnormal_tumor_incidence	0.83041601
86	MP0008877_abnormal_DNA_methylation	0.81837143
87	MP0002163_abnormal_gland_morphology	0.80806963
88	MP0005645_abnormal_hypothalamus_physiol	0.79549538
89	MP0000703_abnormal_thymus_morphology	0.78851411
90	MP0002405_respiratory_system_inflammati	0.78671929
91	MP0002139_abnormal_hepatobiliary_system	0.78594657
92	MP0004145_abnormal_muscle_electrophysio	0.74242817
93	MP0005085_abnormal_gallbladder_physiolo	0.70409194
94	MP0008873_increased_physiological_sensi	0.69442972
95	MP0006036_abnormal_mitochondrial_physio	0.66321617
96	MP0005636_abnormal_mineral_homeostasis	0.64970590
97	MP0008995_early_reproductive_senescence	0.64866152
98	MP0005390_skeleton_phenotype	0.63986609
99	MP0005084_abnormal_gallbladder_morpholo	0.63705391
100	MP0009643_abnormal_urine_homeostasis	0.63642698

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Cerebellar dysplasia (HP:0007033)	6.63845209
2	Type II lissencephaly (HP:0007260)	6.60731384
3	Hypoplasia of the pons (HP:0012110)	5.96546824
4	Abnormality of the pons (HP:0007361)	5.70357710
5	Retinal atrophy (HP:0001105)	5.55146813
6	Decreased electroretinogram (ERG) amplitude (HP:0000654)	5.47729479
7	IgG deficiency (HP:0004315)	4.86025904
8	Retinal dysplasia (HP:0007973)	4.81781642
9	Abolished electroretinogram (ERG) (HP:0000550)	4.01758706
10	Fatigue (HP:0012378)	3.73461447
11	Buphthalmos (HP:0000557)	3.64236296
12	Elevated erythrocyte sedimentation rate (HP:0003565)	3.61727971
13	Aplasia/Hypoplasia affecting the retina (HP:0008061)	3.41568534
14	Severe muscular hypotonia (HP:0006829)	3.08851430
15	Global brain atrophy (HP:0002283)	3.04166837
16	Abnormality of alanine metabolism (HP:0010916)	2.90585141
17	Hyperalaninemia (HP:0003348)	2.90585141
18	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.90585141
19	Congenital stationary night blindness (HP:0007642)	2.84419091
20	T lymphocytopenia (HP:0005403)	2.80172676
21	Abnormality of eosinophils (HP:0001879)	2.70868499
22	3-Methylglutaconic aciduria (HP:0003535)	2.60133077
23	Eosinophilia (HP:0001880)	2.48496369
24	Abnormality of T cell number (HP:0011839)	2.44497517
25	Hypobetalipoproteinemia (HP:0003563)	2.39918408
26	Methylmalonic acidemia (HP:0002912)	2.39857945
27	Conical tooth (HP:0000698)	2.34308563
28	Abnormality of the renal cortex (HP:0011035)	2.32290348
29	Increased CSF lactate (HP:0002490)	2.30916611
30	Congenital glaucoma (HP:0001087)	2.30484535
31	Nephronophthisis (HP:0000090)	2.27375865
32	Lipid accumulation in hepatocytes (HP:0006561)	2.25414819
33	Dyskinesia (HP:0100660)	2.24310459
34	Myositis (HP:0100614)	2.23275262
35	Mitochondrial inheritance (HP:0001427)	2.22711165
36	Difficulty climbing stairs (HP:0003551)	2.20363728
37	Abnormality of cells of the erythroid lineage (HP:0012130)	2.20096470
38	Type 2 muscle fiber atrophy (HP:0003554)	2.19595173
39	Severe combined immunodeficiency (HP:0004430)	2.19303581
40	Molar tooth sign on MRI (HP:0002419)	2.19048191
41	Abnormality of midbrain morphology (HP:0002418)	2.19048191
42	Abnormality of T cells (HP:0002843)	2.16711332
43	Generalized muscle weakness (HP:0003324)	2.15801603
44	Brushfield spots (HP:0001088)	2.14766330
45	Akinesia (HP:0002304)	2.14486953
46	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.09726338
47	Methylmalonic aciduria (HP:0012120)	2.09631023
48	Pachygyria (HP:0001302)	2.08115647
49	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.07142485
50	Hepatocellular necrosis (HP:0001404)	2.06632216
51	Attenuation of retinal blood vessels (HP:0007843)	2.04841394
52	Hepatic necrosis (HP:0002605)	2.01982713
53	Medial flaring of the eyebrow (HP:0010747)	2.01381022
54	IgM deficiency (HP:0002850)	2.00355643
55	Increased hepatocellular lipid droplets (HP:0006565)	2.00116691
56	Lissencephaly (HP:0001339)	1.99713216
57	Increased IgM level (HP:0003496)	1.99195487
58	Acanthocytosis (HP:0001927)	1.98985116
59	Hypoplasia of the brainstem (HP:0002365)	1.98974016
60	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.98974016
61	Neurodegeneration (HP:0002180)	1.98848025
62	Increased serum lactate (HP:0002151)	1.98428818
63	Pancreatic cysts (HP:0001737)	1.96621957
64	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.95047271
65	Muscle fiber atrophy (HP:0100295)	1.94776258
66	Stomatitis (HP:0010280)	1.94516166
67	Abnormality of the renal medulla (HP:0100957)	1.94317764
68	Abnormal number of erythroid precursors (HP:0012131)	1.92016911
69	Metabolic alkalosis (HP:0200114)	1.91638768
70	Leukocytosis (HP:0001974)	1.90043244
71	Hypoproteinemia (HP:0003075)	1.89934517
72	Granulocytopenia (HP:0001913)	1.89144117
73	Panhypogammaglobulinemia (HP:0003139)	1.89069215
74	Orchitis (HP:0100796)	1.88810574
75	Retrobulbar optic neuritis (HP:0100654)	1.88621684
76	Optic neuritis (HP:0100653)	1.88621684
77	Aplasia/hypoplasia of the uterus (HP:0008684)	1.88619377
78	Encephalitis (HP:0002383)	1.87631219
79	Abnormal albumin level (HP:0012116)	1.86966035
80	Hypoalbuminemia (HP:0003073)	1.86966035
81	Intellectual disability, profound (HP:0002187)	1.86288524
82	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.83635102
83	Pallor (HP:0000980)	1.83262907
84	Stomach cancer (HP:0012126)	1.80593829
85	Severe global developmental delay (HP:0011344)	1.80031047
86	Renal cortical cysts (HP:0000803)	1.79145468
87	Hypoplasia of the uterus (HP:0000013)	1.77928322
88	Pancreatic fibrosis (HP:0100732)	1.77329159
89	Increased intramyocellular lipid droplets (HP:0012240)	1.76905273
90	Acute necrotizing encephalopathy (HP:0006965)	1.76019416
91	Keratitis (HP:0000491)	1.74628027
92	Mesangial abnormality (HP:0001966)	1.74427807
93	Decreased circulating renin level (HP:0003351)	1.73218948
94	Abnormal rod and cone electroretinograms (HP:0008323)	1.73151358
95	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.70833054
96	Absent/shortened dynein arms (HP:0200106)	1.70833054
97	Hyperglycinemia (HP:0002154)	1.70627959
98	Increased muscle lipid content (HP:0009058)	1.70262238
99	Non-midline cleft lip (HP:0100335)	1.69616536
100	Megalocornea (HP:0000485)	1.69042620

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	6.48886998
2	TXK	4.56001171
3	TLK1	3.93962121
4	ZAK	3.57782018
5	MARK3	3.03863510
6	STK10	2.92283195
7	MAP4K2	2.79143180
8	ADRBK2	2.36120389
9	MAP2K2	2.27252661
10	BCKDK	2.08716856
11	MAP4K1	2.08600908
12	KIT	1.99130907
13	PIM1	1.90171389
14	GRK6	1.89002951
15	PDK2	1.73263264
16	MAPKAPK3	1.73091208
17	FES	1.62655998
18	IKBKB	1.52750495
19	NUAK1	1.49993601
20	GRK1	1.43025553
21	FRK	1.41940101
22	PINK1	1.37735138
23	ITK	1.36130941
24	SYK	1.27528565
25	MAP3K14	1.21976271
26	TEC	1.20935566
27	TNK2	1.20872025
28	KDR	1.19516345
29	WNK4	1.19490824
30	PTK2B	1.16939973
31	CAMKK2	1.16059443
32	MATK	1.11287147
33	CSF1R	1.09306149
34	BMPR1B	1.08233736
35	LCK	1.07552351
36	FLT3	1.07236480
37	NLK	0.97688732
38	PHKG1	0.96997860
39	PHKG2	0.96997860
40	MAP2K6	0.93656510
41	GRK5	0.88640448
42	PASK	0.87516259
43	ZAP70	0.84998821
44	PRKCQ	0.78876588
45	TESK2	0.78732928
46	TBK1	0.78062816
47	MST4	0.77996210
48	VRK1	0.73714619
49	LYN	0.72089498
50	EPHA3	0.70111418
51	TIE1	0.69782971
52	MAP3K13	0.68451166
53	INSRR	0.67818116
54	CAMKK1	0.67687072
55	CDK8	0.66808998
56	STK11	0.65778046
57	RPS6KA5	0.65371252
58	TGFBR1	0.64954519
59	MAPKAPK5	0.64486809
60	BTK	0.63136331
61	IKBKE	0.61883146
62	GRK7	0.61371213
63	DAPK1	0.60226897
64	JAK3	0.59329298
65	ERN1	0.58528764
66	DAPK2	0.57374208
67	MAPK7	0.57032885
68	STK16	0.53608643
69	JAK1	0.52962970
70	PRKCH	0.52866718
71	ADRBK1	0.52132659
72	HCK	0.50973018
73	VRK2	0.50928558
74	IGF1R	0.50598984
75	OXSR1	0.48480876
76	OBSCN	0.47310928
77	PIK3CA	0.47271937
78	ABL1	0.42593149
79	PIK3CG	0.41619079
80	TRPM7	0.40222029
81	BMPR2	0.39256250
82	IRAK1	0.39140254
83	RPS6KB2	0.37833187
84	CHUK	0.37345616
85	RIPK4	0.35351823
86	PRKCA	0.34966308
87	CSNK1G3	0.34842820
88	LMTK2	0.34700002
89	PRKCD	0.34659555
90	PKN1	0.32032008
91	AKT2	0.29727878
92	CSNK1D	0.28059491
93	CSNK2A1	0.27548591
94	CDK4	0.27293542
95	MAPK11	0.25362847
96	NME2	0.25072442
97	ABL2	0.24022783
98	TYK2	0.23951914
99	CDK19	0.23878623
100	CSNK1A1	0.23291831

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.66768812
2	Allograft rejection_Homo sapiens_hsa05330	3.60148652
3	Graft-versus-host disease_Homo sapiens_hsa05332	3.47177591
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.45958213
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.43803958
6	Ribosome_Homo sapiens_hsa03010	3.43624401
7	Primary immunodeficiency_Homo sapiens_hsa05340	2.83495833
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.58383957
9	RNA polymerase_Homo sapiens_hsa03020	2.48114202
10	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.21811801
11	Antigen processing and presentation_Homo sapiens_hsa04612	2.12284661
12	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.10687670
13	Oxidative phosphorylation_Homo sapiens_hsa00190	2.09361084
14	Linoleic acid metabolism_Homo sapiens_hsa00591	2.08042874
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.84001535
16	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.83119651
17	Leishmaniasis_Homo sapiens_hsa05140	1.78169647
18	Parkinsons disease_Homo sapiens_hsa05012	1.69903640
19	Sulfur metabolism_Homo sapiens_hsa00920	1.67733139
20	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.57453799
21	Proteasome_Homo sapiens_hsa03050	1.56766210
22	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.56089272
23	Phototransduction_Homo sapiens_hsa04744	1.55857319
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.47339002
25	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.41259292
26	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.36693384
27	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.32579694
28	Rheumatoid arthritis_Homo sapiens_hsa05323	1.26217662
29	Viral myocarditis_Homo sapiens_hsa05416	1.26189672
30	Regulation of autophagy_Homo sapiens_hsa04140	1.24445287
31	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.19567242
32	RNA degradation_Homo sapiens_hsa03018	1.18632076
33	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.17907291
34	Caffeine metabolism_Homo sapiens_hsa00232	1.15534348
35	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.13347452
36	One carbon pool by folate_Homo sapiens_hsa00670	1.10111138
37	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.09106724
38	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.06532358
39	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.05209853
40	Alzheimers disease_Homo sapiens_hsa05010	1.02773673
41	Homologous recombination_Homo sapiens_hsa03440	0.99083078
42	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.98702146
43	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.95773352
44	Pyrimidine metabolism_Homo sapiens_hsa00240	0.95762514
45	Ether lipid metabolism_Homo sapiens_hsa00565	0.94466578
46	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.93855482
47	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.92942300
48	Huntingtons disease_Homo sapiens_hsa05016	0.91600488
49	Selenocompound metabolism_Homo sapiens_hsa00450	0.89070152
50	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.88410661
51	Purine metabolism_Homo sapiens_hsa00230	0.85445081
52	Cardiac muscle contraction_Homo sapiens_hsa04260	0.85042627
53	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.80859240
54	Tryptophan metabolism_Homo sapiens_hsa00380	0.80492868
55	Toxoplasmosis_Homo sapiens_hsa05145	0.78054472
56	Herpes simplex infection_Homo sapiens_hsa05168	0.77988468
57	Peroxisome_Homo sapiens_hsa04146	0.69142084
58	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.68679530
59	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.68621065
60	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.67909231
61	Basal transcription factors_Homo sapiens_hsa03022	0.67715750
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.66849309
63	Olfactory transduction_Homo sapiens_hsa04740	0.59133631
64	TNF signaling pathway_Homo sapiens_hsa04668	0.57463802
65	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.57041198
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.55490492
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.54984607
68	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.54280493
69	Salivary secretion_Homo sapiens_hsa04970	0.52235714
70	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.50459107
71	Retinol metabolism_Homo sapiens_hsa00830	0.46336014
72	Fanconi anemia pathway_Homo sapiens_hsa03460	0.44051981
73	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.42062169
74	Propanoate metabolism_Homo sapiens_hsa00640	0.41776077
75	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.41666833
76	Base excision repair_Homo sapiens_hsa03410	0.40945218
77	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.40208028
78	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.40182361
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39742003
80	Metabolic pathways_Homo sapiens_hsa01100	0.38957759
81	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.37064577
82	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.36674747
83	Osteoclast differentiation_Homo sapiens_hsa04380	0.36430286
84	Taste transduction_Homo sapiens_hsa04742	0.36180750
85	ABC transporters_Homo sapiens_hsa02010	0.36017887
86	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.35421610
87	Nucleotide excision repair_Homo sapiens_hsa03420	0.35217423
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.35183473
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.34951607
90	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.32659811
91	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.29240711
92	Spliceosome_Homo sapiens_hsa03040	0.27787911
93	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.27431603
94	Measles_Homo sapiens_hsa05162	0.26947823
95	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.25982875
96	Sulfur relay system_Homo sapiens_hsa04122	0.25682783
97	DNA replication_Homo sapiens_hsa03030	0.25557909
98	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.22182376
99	Butanoate metabolism_Homo sapiens_hsa00650	0.21516685
100	Mineral absorption_Homo sapiens_hsa04978	0.21016398

RPL23AP96

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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