ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	8.22663596
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	6.89808764
3	cytidine deamination (GO:0009972)	6.03910487
4	cytidine metabolic process (GO:0046087)	6.03910487
5	cytidine catabolic process (GO:0006216)	6.03910487
6	protein neddylation (GO:0045116)	5.56094238
7	pyrimidine ribonucleoside catabolic process (GO:0046133)	5.21980380
8	behavioral response to nicotine (GO:0035095)	3.72446294
9	negative regulation of heart rate (GO:0010459)	3.72440480
10	interferon-gamma production (GO:0032609)	3.70161890
11	sequestering of actin monomers (GO:0042989)	3.62616874
12	preassembly of GPI anchor in ER membrane (GO:0016254)	3.58488124
13	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.54235859
14	protein complex biogenesis (GO:0070271)	3.53207747
15	water-soluble vitamin biosynthetic process (GO:0042364)	3.48664556
16	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.38127099
17	metallo-sulfur cluster assembly (GO:0031163)	3.34697205
18	iron-sulfur cluster assembly (GO:0016226)	3.34697205
19	prenylation (GO:0097354)	3.34389664
20	protein prenylation (GO:0018342)	3.34389664
21	ubiquinone biosynthetic process (GO:0006744)	3.34204918
22	protein deneddylation (GO:0000338)	3.31240370
23	pyrimidine nucleoside catabolic process (GO:0046135)	3.29897621
24	ATP synthesis coupled proton transport (GO:0015986)	3.29258338
25	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.29258338
26	ubiquinone metabolic process (GO:0006743)	3.27635885
27	pseudouridine synthesis (GO:0001522)	3.25242895
28	protein polyglutamylation (GO:0018095)	3.25181418
29	platelet dense granule organization (GO:0060155)	3.21516304
30	negative regulation of thymocyte apoptotic process (GO:0070244)	3.20384364
31	proteasome assembly (GO:0043248)	3.19004631
32	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.18096350
33	termination of RNA polymerase III transcription (GO:0006386)	3.18096350
34	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.18040991
35	NADH dehydrogenase complex assembly (GO:0010257)	3.18040991
36	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.18040991
37	GPI anchor biosynthetic process (GO:0006506)	3.16393490
38	GPI anchor metabolic process (GO:0006505)	3.14415963
39	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.14067807
40	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.14067807
41	mitochondrial respiratory chain complex assembly (GO:0033108)	3.12679289
42	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.10322059
43	piRNA metabolic process (GO:0034587)	3.09483581
44	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.07930929
45	chaperone-mediated protein transport (GO:0072321)	3.07668850
46	regulation of cilium movement (GO:0003352)	3.07504077
47	tachykinin receptor signaling pathway (GO:0007217)	3.07215293
48	amino acid salvage (GO:0043102)	3.06645591
49	L-methionine salvage (GO:0071267)	3.06645591
50	L-methionine biosynthetic process (GO:0071265)	3.06645591
51	mannosylation (GO:0097502)	3.02067931
52	fucose catabolic process (GO:0019317)	3.01063414
53	L-fucose metabolic process (GO:0042354)	3.01063414
54	L-fucose catabolic process (GO:0042355)	3.01063414
55	adenosine metabolic process (GO:0046085)	2.98252537
56	maturation of 5.8S rRNA (GO:0000460)	2.96583684
57	organelle membrane fusion (GO:0090174)	2.92155002
58	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.91375752
59	regulation of cellular amino acid metabolic process (GO:0006521)	2.90735630
60	negative regulation of appetite (GO:0032099)	2.88658152
61	negative regulation of response to food (GO:0032096)	2.88658152
62	C-terminal protein lipidation (GO:0006501)	2.85346741
63	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.83638851
64	positive regulation of protein homodimerization activity (GO:0090073)	2.83165250
65	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.81389432
66	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.76473759
67	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.76089011
68	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.75154611
69	amine catabolic process (GO:0009310)	2.73920478
70	cellular biogenic amine catabolic process (GO:0042402)	2.73920478
71	negative regulation of T cell apoptotic process (GO:0070233)	2.73294494
72	electron transport chain (GO:0022900)	2.70609901
73	base-excision repair, AP site formation (GO:0006285)	2.69792451
74	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.69169730
75	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.69169730
76	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.69169730
77	pyrimidine-containing compound catabolic process (GO:0072529)	2.69043129
78	thrombin receptor signaling pathway (GO:0070493)	2.67246525
79	branched-chain amino acid catabolic process (GO:0009083)	2.65664534
80	quinone biosynthetic process (GO:1901663)	2.65116199
81	respiratory electron transport chain (GO:0022904)	2.65012369
82	C-terminal protein amino acid modification (GO:0018410)	2.64904610
83	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.63636911
84	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.63552943
85	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.63552943
86	cullin deneddylation (GO:0010388)	2.63087311
87	S-adenosylmethionine metabolic process (GO:0046500)	2.61121466
88	nucleobase biosynthetic process (GO:0046112)	2.61042199
89	axoneme assembly (GO:0035082)	2.60673353
90	positive regulation of prostaglandin secretion (GO:0032308)	2.59884097
91	positive regulation of granulocyte differentiation (GO:0030854)	2.59100615
92	respiratory chain complex IV assembly (GO:0008535)	2.58612941
93	cellular ketone body metabolic process (GO:0046950)	2.54190355
94	protein peptidyl-prolyl isomerization (GO:0000413)	2.54004936
95	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.53974802
96	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.53557063
97	purine-containing compound salvage (GO:0043101)	2.53145664
98	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.51857403
99	actin nucleation (GO:0045010)	2.51674085
100	negative regulation of telomere maintenance (GO:0032205)	2.50603393

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.68416905
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.67068134
3	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.54408307
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.44162888
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.38295404
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.37660160
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.29132848
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.19053640
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.10688074
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.99913432
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.58051642
12	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.56718506
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.26034406
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.17450390
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.16988302
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.12261465
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.07974511
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.93812590
19	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.91153914
20	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.89175215
21	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.85087866
22	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.84928816
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.84086012
24	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.76397984
25	VDR_22108803_ChIP-Seq_LS180_Human	1.74562984
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.71951007
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.70616581
28	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.68766641
29	EWS_26573619_Chip-Seq_HEK293_Human	1.67991868
30	FOXP3_21729870_ChIP-Seq_TREG_Human	1.67750190
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.63485715
32	AR_20517297_ChIP-Seq_VCAP_Human	1.58947649
33	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.56834177
34	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.55419832
35	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.54410508
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.52839431
37	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.49865052
38	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.48413252
39	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.47047271
40	SOX2_19829295_ChIP-Seq_ESCs_Human	1.44561303
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.44561303
42	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.41461270
43	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.39392082
44	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.36490633
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.34321890
46	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.34321890
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.34257015
48	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.34047122
49	TAF15_26573619_Chip-Seq_HEK293_Human	1.32305720
50	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.31623745
51	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.29891051
52	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.29615815
53	FUS_26573619_Chip-Seq_HEK293_Human	1.28883299
54	GBX2_23144817_ChIP-Seq_PC3_Human	1.26023050
55	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.25755867
56	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.24777580
57	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.24298948
58	P300_19829295_ChIP-Seq_ESCs_Human	1.17661921
59	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.16909023
60	GATA3_26560356_Chip-Seq_TH2_Human	1.15555471
61	ER_23166858_ChIP-Seq_MCF-7_Human	1.12538479
62	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.12037207
63	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.09920422
64	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09833912
65	ERG_20517297_ChIP-Seq_VCAP_Human	1.07372490
66	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.06860531
67	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.06551997
68	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.05473934
69	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.03938375
70	GABP_19822575_ChIP-Seq_HepG2_Human	1.03606552
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.03475041
72	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.03335781
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01774818
74	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.01587130
75	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01565579
76	NCOR_22424771_ChIP-Seq_293T_Human	1.00741050
77	NANOG_20526341_ChIP-Seq_ESCs_Human	1.00435797
78	DCP1A_22483619_ChIP-Seq_HELA_Human	0.99535358
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.98813912
80	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.98665704
81	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.97547397
82	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.96381984
83	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.94429895
84	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92369186
85	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.91387910
86	CBP_20019798_ChIP-Seq_JUKART_Human	0.91387910
87	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90559457
88	GATA3_27048872_Chip-Seq_THYMUS_Human	0.89874628
89	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.89245568
90	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.88273095
91	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.87870923
92	MYB_26560356_Chip-Seq_TH2_Human	0.87724196
93	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.86000170
94	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.85820885
95	HTT_18923047_ChIP-ChIP_STHdh_Human	0.85600175
96	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.85184643
97	RNF2_27304074_Chip-Seq_NSC_Mouse	0.84913355
98	STAT1_20625510_ChIP-Seq_HELA_Human	0.83922365
99	ERA_21632823_ChIP-Seq_H3396_Human	0.83704919
100	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.83608037

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005464_abnormal_platelet_physiology	3.81390005
2	MP0006054_spinal_hemorrhage	3.75848660
3	MP0008877_abnormal_DNA_methylation	2.94008890
4	MP0006072_abnormal_retinal_apoptosis	2.76711178
5	MP0005671_abnormal_response_to	2.66795575
6	MP0004147_increased_porphyrin_level	2.53563026
7	MP0010386_abnormal_urinary_bladder	2.41181820
8	MP0008058_abnormal_DNA_repair	2.29406894
9	MP0001968_abnormal_touch/_nociception	2.27323464
10	MP0003195_calcinosis	2.22561032
11	MP0002736_abnormal_nociception_after	2.11410980
12	MP0005410_abnormal_fertilization	2.04894677
13	MP0001835_abnormal_antigen_presentation	1.99331338
14	MP0003011_delayed_dark_adaptation	1.97795409
15	MP0008872_abnormal_physiological_respon	1.94493626
16	MP0001905_abnormal_dopamine_level	1.90658423
17	MP0002102_abnormal_ear_morphology	1.86859342
18	MP0005551_abnormal_eye_electrophysiolog	1.83823064
19	MP0008995_early_reproductive_senescence	1.81965227
20	MP0001529_abnormal_vocalization	1.80170153
21	MP0004142_abnormal_muscle_tone	1.77902592
22	MP0006036_abnormal_mitochondrial_physio	1.75758877
23	MP0003646_muscle_fatigue	1.69614898
24	MP0006276_abnormal_autonomic_nervous	1.65088725
25	MP0002254_reproductive_system_inflammat	1.61584844
26	MP0008789_abnormal_olfactory_epithelium	1.59162201
27	MP0006035_abnormal_mitochondrial_morpho	1.58200327
28	MP0005253_abnormal_eye_physiology	1.55837065
29	MP0005645_abnormal_hypothalamus_physiol	1.50190420
30	MP0009333_abnormal_splenocyte_physiolog	1.49056964
31	MP0003693_abnormal_embryo_hatching	1.42495896
32	MP0000372_irregular_coat_pigmentation	1.40768333
33	MP0005646_abnormal_pituitary_gland	1.38803360
34	MP0001873_stomach_inflammation	1.38688470
35	MP0002653_abnormal_ependyma_morphology	1.36036604
36	MP0001485_abnormal_pinna_reflex	1.31965909
37	MP0002138_abnormal_hepatobiliary_system	1.31714640
38	MP0005084_abnormal_gallbladder_morpholo	1.30951189
39	MP0006292_abnormal_olfactory_placode	1.29664965
40	MP0003186_abnormal_redox_activity	1.28001900
41	MP0003786_premature_aging	1.27843365
42	MP0009764_decreased_sensitivity_to	1.27227626
43	MP0002733_abnormal_thermal_nociception	1.26422615
44	MP0001800_abnormal_humoral_immune	1.23315448
45	MP0004145_abnormal_muscle_electrophysio	1.23293786
46	MP0002234_abnormal_pharynx_morphology	1.23241959
47	MP0000465_gastrointestinal_hemorrhage	1.19715255
48	MP0005000_abnormal_immune_tolerance	1.18764293
49	MP0000685_abnormal_immune_system	1.18678123
50	MP0001970_abnormal_pain_threshold	1.18636904
51	MP0008004_abnormal_stomach_pH	1.17849253
52	MP0002751_abnormal_autonomic_nervous	1.17083742
53	MP0003950_abnormal_plasma_membrane	1.16433577
54	MP0005389_reproductive_system_phenotype	1.12368349
55	MP0001919_abnormal_reproductive_system	1.11945031
56	MP0000230_abnormal_systemic_arterial	1.10409288
57	MP0001984_abnormal_olfaction	1.09983303
58	MP0005394_taste/olfaction_phenotype	1.09256731
59	MP0005499_abnormal_olfactory_system	1.09256731
60	MP0002148_abnormal_hypersensitivity_rea	1.08700364
61	MP0005387_immune_system_phenotype	1.07435472
62	MP0001790_abnormal_immune_system	1.07435472
63	MP0002272_abnormal_nervous_system	1.07354202
64	MP0009785_altered_susceptibility_to	1.06591245
65	MP0002723_abnormal_immune_serum	1.06264546
66	MP0000689_abnormal_spleen_morphology	1.04728829
67	MP0008875_abnormal_xenobiotic_pharmacok	1.04262553
68	MP0009046_muscle_twitch	1.03730536
69	MP0001727_abnormal_embryo_implantation	1.03185261
70	MP0003122_maternal_imprinting	1.01833122
71	MP0003763_abnormal_thymus_physiology	1.01168037
72	MP0003724_increased_susceptibility_to	0.99854072
73	MP0002420_abnormal_adaptive_immunity	0.99208730
74	MP0004742_abnormal_vestibular_system	0.98329104
75	MP0002398_abnormal_bone_marrow	0.98018502
76	MP0001963_abnormal_hearing_physiology	0.96431838
77	MP0001929_abnormal_gametogenesis	0.95914248
78	MP0005636_abnormal_mineral_homeostasis	0.95096494
79	MP0001819_abnormal_immune_cell	0.94158446
80	MP0002876_abnormal_thyroid_physiology	0.92608517
81	MP0005075_abnormal_melanosome_morpholog	0.92196153
82	MP0002452_abnormal_antigen_presenting	0.90406850
83	MP0005167_abnormal_blood-brain_barrier	0.90100770
84	MP0003787_abnormal_imprinting	0.89683760
85	MP0004043_abnormal_pH_regulation	0.88524583
86	MP0002160_abnormal_reproductive_system	0.85760916
87	MP0005360_urolithiasis	0.85555367
88	MP0001486_abnormal_startle_reflex	0.79581286
89	MP0003718_maternal_effect	0.79218460
90	MP0003698_abnormal_male_reproductive	0.78954345
91	MP0005310_abnormal_salivary_gland	0.78691707
92	MP0002752_abnormal_somatic_nervous	0.78251915
93	MP0002722_abnormal_immune_system	0.77688537
94	MP0009697_abnormal_copulation	0.77470246
95	MP0003866_abnormal_defecation	0.77355818
96	MP0000631_abnormal_neuroendocrine_gland	0.77216525
97	MP0002429_abnormal_blood_cell	0.76113852
98	MP0002184_abnormal_innervation	0.75968482
99	MP0000716_abnormal_immune_system	0.75019253
100	MP0001663_abnormal_digestive_system	0.73520223

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	4.38891023
2	Type 2 muscle fiber atrophy (HP:0003554)	4.13999673
3	Acute necrotizing encephalopathy (HP:0006965)	4.11522920
4	Acute encephalopathy (HP:0006846)	3.73848418
5	Mitochondrial inheritance (HP:0001427)	3.62469886
6	Muscle fiber atrophy (HP:0100295)	3.61419052
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.57781468
8	B lymphocytopenia (HP:0010976)	3.47938012
9	Progressive macrocephaly (HP:0004481)	3.42202204
10	Increased CSF lactate (HP:0002490)	3.36093668
11	Increased hepatocellular lipid droplets (HP:0006565)	3.18602543
12	Hepatocellular necrosis (HP:0001404)	3.17773486
13	Hepatic necrosis (HP:0002605)	3.15376455
14	Abnormality of B cell number (HP:0010975)	3.13561234
15	Renal Fanconi syndrome (HP:0001994)	3.06104476
16	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.00527449
17	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.97775275
18	Pendular nystagmus (HP:0012043)	2.97487112
19	Petechiae (HP:0000967)	2.97105954
20	Lipid accumulation in hepatocytes (HP:0006561)	2.93842333
21	Severe combined immunodeficiency (HP:0004430)	2.87568227
22	Decreased central vision (HP:0007663)	2.86158325
23	Increased serum lactate (HP:0002151)	2.83151720
24	Abolished electroretinogram (ERG) (HP:0000550)	2.79884492
25	Cerebral edema (HP:0002181)	2.79145806
26	Attenuation of retinal blood vessels (HP:0007843)	2.78539252
27	Molar tooth sign on MRI (HP:0002419)	2.78088122
28	Abnormality of midbrain morphology (HP:0002418)	2.78088122
29	Pancreatic cysts (HP:0001737)	2.65522575
30	Keratoconus (HP:0000563)	2.63760710
31	Increased corneal curvature (HP:0100692)	2.63760710
32	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.63695207
33	Abnormal ciliary motility (HP:0012262)	2.60317068
34	Congenital stationary night blindness (HP:0007642)	2.58335551
35	Prolonged bleeding time (HP:0003010)	2.55102139
36	Abnormal rod and cone electroretinograms (HP:0008323)	2.54640996
37	Medial flaring of the eyebrow (HP:0010747)	2.51175535
38	Hypoproteinemia (HP:0003075)	2.47600985
39	Abnormality of the prostate (HP:0008775)	2.46349091
40	Exertional dyspnea (HP:0002875)	2.41981923
41	Optic disc pallor (HP:0000543)	2.41664933
42	IgG deficiency (HP:0004315)	2.34651773
43	Hyperglycinemia (HP:0002154)	2.32489944
44	Abnormal respiratory motile cilium physiology (HP:0012261)	2.28739524
45	Intestinal atresia (HP:0011100)	2.26569331
46	Lactic acidosis (HP:0003128)	2.23952454
47	Hypomagnesemia (HP:0002917)	2.23715041
48	Elevated erythrocyte sedimentation rate (HP:0003565)	2.22358833
49	Aplastic anemia (HP:0001915)	2.20564271
50	Thyroiditis (HP:0100646)	2.20155259
51	Exercise intolerance (HP:0003546)	2.17226028
52	Abnormality of the renal cortex (HP:0011035)	2.14589403
53	Increased intramyocellular lipid droplets (HP:0012240)	2.14337440
54	Panhypogammaglobulinemia (HP:0003139)	2.13982815
55	Renal cortical cysts (HP:0000803)	2.11372856
56	Combined immunodeficiency (HP:0005387)	2.11028919
57	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.09684835
58	Purpura (HP:0000979)	2.04667431
59	Short tibia (HP:0005736)	2.04290862
60	Hyperlipoproteinemia (HP:0010980)	2.00070597
61	Large for gestational age (HP:0001520)	1.98501657
62	Asplenia (HP:0001746)	1.94997020
63	Congenital primary aphakia (HP:0007707)	1.93764443
64	Abnormal respiratory motile cilium morphology (HP:0005938)	1.93635327
65	Abnormal respiratory epithelium morphology (HP:0012253)	1.93635327
66	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.93432451
67	Abnormal protein N-linked glycosylation (HP:0012347)	1.93432451
68	Abnormal protein glycosylation (HP:0012346)	1.93432451
69	Abnormal glycosylation (HP:0012345)	1.93432451
70	True hermaphroditism (HP:0010459)	1.92755375
71	Methylmalonic acidemia (HP:0002912)	1.91040664
72	Lethargy (HP:0001254)	1.89460837
73	Pancreatic fibrosis (HP:0100732)	1.89034857
74	Optic neuritis (HP:0100653)	1.88145246
75	Retrobulbar optic neuritis (HP:0100654)	1.88145246
76	Gait imbalance (HP:0002141)	1.87500462
77	Nephronophthisis (HP:0000090)	1.86010387
78	Respiratory failure (HP:0002878)	1.85885853
79	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.84433707
80	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.83571314
81	Menorrhagia (HP:0000132)	1.83489731
82	Abnormality of T cell physiology (HP:0011840)	1.82717211
83	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.82715006
84	Hyperinsulinemic hypoglycemia (HP:0000825)	1.82276986
85	Abnormality of urine glucose concentration (HP:0011016)	1.81376586
86	Glycosuria (HP:0003076)	1.81376586
87	Type I transferrin isoform profile (HP:0003642)	1.81251953
88	Decreased muscle mass (HP:0003199)	1.81058106
89	Agitation (HP:0000713)	1.80908953
90	Fatigable weakness (HP:0003473)	1.80397241
91	Abnormality of the neuromuscular junction (HP:0003398)	1.80397241
92	Abnormal drinking behavior (HP:0030082)	1.78270847
93	Polydipsia (HP:0001959)	1.78270847
94	Joint swelling (HP:0001386)	1.78085425
95	Increased muscle lipid content (HP:0009058)	1.77704344
96	Chronic mucocutaneous candidiasis (HP:0002728)	1.77571062
97	Recurrent cutaneous fungal infections (HP:0011370)	1.77571062
98	Abnormal albumin level (HP:0012116)	1.77524384
99	Hypoalbuminemia (HP:0003073)	1.77524384
100	Volvulus (HP:0002580)	1.77361250

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	4.91785543
2	MAP4K2	4.37836093
3	MST4	3.10808704
4	TESK2	3.03313509
5	TXK	2.98517166
6	ADRBK2	2.60707178
7	ZAK	2.53240749
8	NUAK1	2.23873858
9	TAOK3	2.12794115
10	GRK6	2.11523394
11	PINK1	1.86935530
12	VRK2	1.79065560
13	TRIM28	1.73084336
14	TEC	1.66554357
15	SRPK1	1.54318048
16	BCR	1.51004124
17	TESK1	1.49392392
18	EIF2AK1	1.49288170
19	EIF2AK3	1.46335336
20	MAP4K1	1.45402660
21	KDR	1.45235657
22	RPS6KA4	1.43002402
23	MAP2K6	1.40577658
24	CSNK1G3	1.30459388
25	TIE1	1.26766169
26	GRK1	1.24899530
27	SYK	1.18612860
28	BMPR1B	1.18003627
29	BTK	1.16926905
30	TLK1	1.16217052
31	MYLK	1.12887857
32	KIT	1.12075597
33	VRK1	1.11469287
34	PAK3	1.08344454
35	CSNK1G1	1.06579783
36	WNK4	1.06275563
37	CSNK1G2	1.04546739
38	DYRK2	1.03517185
39	ITK	1.00924999
40	PLK2	1.00111495
41	FES	0.98664842
42	MAPK13	0.97831016
43	CSNK1A1L	0.96113091
44	STK39	0.95089143
45	GRK5	0.93602503
46	BMPR2	0.89469508
47	STK16	0.89209279
48	PIM2	0.87061198
49	WNK3	0.85282555
50	OXSR1	0.85260529
51	CCNB1	0.79973673
52	RPS6KA5	0.77923026
53	JAK3	0.76337821
54	PTK2B	0.74378392
55	FRK	0.73792763
56	LYN	0.73457021
57	PLK3	0.73165205
58	TSSK6	0.72058951
59	CSF1R	0.70805840
60	PHKG2	0.70719641
61	PHKG1	0.70719641
62	MAPKAPK3	0.67962400
63	TNIK	0.65738862
64	MAP3K12	0.64963730
65	MUSK	0.63545803
66	ERBB3	0.63292489
67	CAMKK2	0.62255800
68	PIK3CG	0.61145117
69	DAPK1	0.58309658
70	PKN1	0.57893749
71	IKBKB	0.56109184
72	LCK	0.55583442
73	RIPK4	0.55252276
74	CDK19	0.54438925
75	PRKCQ	0.53230418
76	MAP3K4	0.48260577
77	DYRK3	0.47877626
78	PBK	0.47583875
79	SIK3	0.45784536
80	MAP2K7	0.44803328
81	TNK2	0.43978012
82	LIMK1	0.42489963
83	IKBKE	0.41104461
84	MKNK1	0.41013110
85	ADRBK1	0.39291995
86	CAMK2A	0.39061583
87	ATR	0.38802258
88	PLK4	0.36635954
89	CAMK1	0.36394756
90	ERBB2	0.35872453
91	MINK1	0.33718944
92	NEK1	0.32667481
93	STK3	0.32544204
94	PRKACA	0.32035861
95	CSNK1A1	0.31106603
96	HCK	0.30242583
97	FLT3	0.29544657
98	CSNK2A1	0.27011712
99	INSRR	0.26768575
100	AURKB	0.26490660

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.87363543
2	RNA polymerase_Homo sapiens_hsa03020	3.26475105
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.16153959
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.07724132
5	Protein export_Homo sapiens_hsa03060	2.76077805
6	Primary immunodeficiency_Homo sapiens_hsa05340	2.60986968
7	Parkinsons disease_Homo sapiens_hsa05012	2.56543237
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.17527761
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.12514344
10	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.05419396
11	Fatty acid elongation_Homo sapiens_hsa00062	2.00578344
12	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.99556183
13	Graft-versus-host disease_Homo sapiens_hsa05332	1.98296486
14	Allograft rejection_Homo sapiens_hsa05330	1.95478688
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.93884802
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.84955953
17	Collecting duct acid secretion_Homo sapiens_hsa04966	1.76580140
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.73292614
19	Steroid biosynthesis_Homo sapiens_hsa00100	1.67491896
20	Pyrimidine metabolism_Homo sapiens_hsa00240	1.63975334
21	Asthma_Homo sapiens_hsa05310	1.59815722
22	Ribosome_Homo sapiens_hsa03010	1.53757964
23	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.53512895
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.51718017
25	Huntingtons disease_Homo sapiens_hsa05016	1.51628544
26	Type I diabetes mellitus_Homo sapiens_hsa04940	1.50411551
27	Propanoate metabolism_Homo sapiens_hsa00640	1.49613228
28	Phototransduction_Homo sapiens_hsa04744	1.48940446
29	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.47357503
30	Alzheimers disease_Homo sapiens_hsa05010	1.35197050
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.32873346
32	Homologous recombination_Homo sapiens_hsa03440	1.30246682
33	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.28196401
34	Purine metabolism_Homo sapiens_hsa00230	1.27361827
35	Rheumatoid arthritis_Homo sapiens_hsa05323	1.26801933
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.25290677
37	Base excision repair_Homo sapiens_hsa03410	1.20279929
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.14093424
39	Antigen processing and presentation_Homo sapiens_hsa04612	1.12777714
40	Non-homologous end-joining_Homo sapiens_hsa03450	1.11635000
41	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.10254566
42	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.07405267
43	One carbon pool by folate_Homo sapiens_hsa00670	0.99517076
44	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.99367946
45	RNA transport_Homo sapiens_hsa03013	0.94901638
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.93262069
47	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.91448464
48	Butanoate metabolism_Homo sapiens_hsa00650	0.89509702
49	Peroxisome_Homo sapiens_hsa04146	0.88474663
50	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.86991500
51	Fanconi anemia pathway_Homo sapiens_hsa03460	0.83393057
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.83355490
53	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.82847055
54	Viral myocarditis_Homo sapiens_hsa05416	0.82291413
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.82049606
56	Mismatch repair_Homo sapiens_hsa03430	0.81730873
57	RNA degradation_Homo sapiens_hsa03018	0.81142809
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.81077538
59	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.79244380
60	Tryptophan metabolism_Homo sapiens_hsa00380	0.78480115
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.78356150
62	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.78352441
63	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.78043991
64	Sulfur metabolism_Homo sapiens_hsa00920	0.76851779
65	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.72542519
66	Spliceosome_Homo sapiens_hsa03040	0.72125931
67	Metabolic pathways_Homo sapiens_hsa01100	0.71306980
68	Nucleotide excision repair_Homo sapiens_hsa03420	0.71012963
69	Retinol metabolism_Homo sapiens_hsa00830	0.69868929
70	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.69038110
71	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.68854696
72	Cardiac muscle contraction_Homo sapiens_hsa04260	0.68445024
73	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.67724534
74	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.66720122
75	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.65822705
76	Glutathione metabolism_Homo sapiens_hsa00480	0.62859557
77	Olfactory transduction_Homo sapiens_hsa04740	0.61723247
78	Folate biosynthesis_Homo sapiens_hsa00790	0.58857612
79	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.56741296
80	Basal transcription factors_Homo sapiens_hsa03022	0.56153928
81	Ether lipid metabolism_Homo sapiens_hsa00565	0.55123038
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.53746284
83	Platelet activation_Homo sapiens_hsa04611	0.53105492
84	Serotonergic synapse_Homo sapiens_hsa04726	0.52643430
85	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.50763994
86	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.50763514
87	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.50494543
88	Fatty acid metabolism_Homo sapiens_hsa01212	0.49332274
89	Alcoholism_Homo sapiens_hsa05034	0.41193858
90	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.40531756
91	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.39822986
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.36393289
93	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.35924667
94	Selenocompound metabolism_Homo sapiens_hsa00450	0.35731852
95	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.33661130
96	Pyruvate metabolism_Homo sapiens_hsa00620	0.32777792
97	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.31804670
98	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.30858333
99	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.29746421
100	Fat digestion and absorption_Homo sapiens_hsa04975	0.28626571

RPL23AP97

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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