ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.77986253
2	water-soluble vitamin biosynthetic process (GO:0042364)	5.60681504
3	rRNA catabolic process (GO:0016075)	5.49630076
4	viral transcription (GO:0019083)	5.06351951
5	translational termination (GO:0006415)	5.01561427
6	ribosomal small subunit assembly (GO:0000028)	4.95043726
7	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.79650437
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.52074257
9	cotranslational protein targeting to membrane (GO:0006613)	4.49489896
10	protein targeting to ER (GO:0045047)	4.45406988
11	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.29002880
12	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.18900168
13	translational elongation (GO:0006414)	4.16578255
14	protein localization to endoplasmic reticulum (GO:0070972)	4.11390235
15	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.97723217
16	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.97723217
17	NADH dehydrogenase complex assembly (GO:0010257)	3.97723217
18	Sertoli cell development (GO:0060009)	3.96523370
19	neuron fate determination (GO:0048664)	3.88076836
20	cellular protein complex disassembly (GO:0043624)	3.82935225
21	protein complex biogenesis (GO:0070271)	3.74759327
22	translational initiation (GO:0006413)	3.69311353
23	axon ensheathment in central nervous system (GO:0032291)	3.58895848
24	central nervous system myelination (GO:0022010)	3.58895848
25	viral life cycle (GO:0019058)	3.52517996
26	mitochondrial respiratory chain complex assembly (GO:0033108)	3.41915848
27	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.35461920
28	proteasome assembly (GO:0043248)	3.34615004
29	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.33334123
30	nonmotile primary cilium assembly (GO:0035058)	3.31871876
31	ncRNA catabolic process (GO:0034661)	3.31765325
32	chaperone-mediated protein transport (GO:0072321)	3.30454085
33	negative regulation of acute inflammatory response (GO:0002674)	3.27617084
34	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	3.27602832
35	radial glial cell differentiation (GO:0060019)	3.26853803
36	protein complex disassembly (GO:0043241)	3.22849589
37	auditory receptor cell stereocilium organization (GO:0060088)	3.22351979
38	ATP synthesis coupled proton transport (GO:0015986)	3.21985662
39	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.21985662
40	DNA deamination (GO:0045006)	3.19627193
41	translation (GO:0006412)	3.13543667
42	macromolecular complex disassembly (GO:0032984)	3.13287075
43	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.00905143
44	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.99309189
45	kinetochore assembly (GO:0051382)	2.97380963
46	anterograde synaptic vesicle transport (GO:0048490)	2.94684187
47	regulation of synapse structural plasticity (GO:0051823)	2.89797339
48	cAMP catabolic process (GO:0006198)	2.89279839
49	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.89142430
50	respiratory electron transport chain (GO:0022904)	2.88572895
51	electron transport chain (GO:0022900)	2.88505054
52	cellular ketone body metabolic process (GO:0046950)	2.85370838
53	retinal ganglion cell axon guidance (GO:0031290)	2.85253932
54	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	2.84058760
55	regulation of podosome assembly (GO:0071801)	2.83575775
56	startle response (GO:0001964)	2.81181841
57	regulation of isotype switching to IgG isotypes (GO:0048302)	2.79914060
58	protein targeting to membrane (GO:0006612)	2.78846423
59	replication fork processing (GO:0031297)	2.78175544
60	regulation of chronic inflammatory response (GO:0002676)	2.77237187
61	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.73239772
62	maturation of 5.8S rRNA (GO:0000460)	2.72360377
63	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.71712695
64	termination of RNA polymerase III transcription (GO:0006386)	2.71712695
65	ribosomal small subunit biogenesis (GO:0042274)	2.71585781
66	somite rostral/caudal axis specification (GO:0032525)	2.70890294
67	negative regulation of T-helper cell differentiation (GO:0045623)	2.70569670
68	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.70569670
69	epithelial cilium movement (GO:0003351)	2.70226990
70	kinetochore organization (GO:0051383)	2.68921607
71	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.68547718
72	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.67327094
73	termination of RNA polymerase I transcription (GO:0006363)	2.66555164
74	cyclic nucleotide catabolic process (GO:0009214)	2.65595238
75	L-ascorbic acid metabolic process (GO:0019852)	2.65206641
76	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.64778748
77	otic vesicle formation (GO:0030916)	2.64496216
78	maturation of SSU-rRNA (GO:0030490)	2.62245147
79	intraciliary transport (GO:0042073)	2.59001348
80	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.57584990
81	pyrimidine nucleobase catabolic process (GO:0006208)	2.56901800
82	ovulation cycle (GO:0042698)	2.56817561
83	ubiquinone biosynthetic process (GO:0006744)	2.56506328
84	intracellular protein transmembrane import (GO:0044743)	2.54380241
85	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.53801103
86	negative regulation of inclusion body assembly (GO:0090084)	2.53468453
87	mRNA catabolic process (GO:0006402)	2.53291915
88	ribosomal large subunit biogenesis (GO:0042273)	2.52381069
89	ketone body metabolic process (GO:1902224)	2.52112470
90	peptidyl-histidine modification (GO:0018202)	2.52045212
91	respiratory chain complex IV assembly (GO:0008535)	2.51706072
92	regulation of cilium movement (GO:0003352)	2.51258125
93	vitamin biosynthetic process (GO:0009110)	2.50696490
94	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	2.49073849
95	hydrogen ion transmembrane transport (GO:1902600)	2.47635045
96	anterograde axon cargo transport (GO:0008089)	2.46175490
97	photoreceptor cell maintenance (GO:0045494)	2.46130970
98	axonemal dynein complex assembly (GO:0070286)	2.46125539
99	cilium movement (GO:0003341)	2.46079727
100	nephron tubule morphogenesis (GO:0072078)	2.45462773

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.25180183
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.41486888
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.36221502
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.02731146
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.97997534
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.65750015
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.63275990
8	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.57452955
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.52573266
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.46143174
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.43192947
12	VDR_22108803_ChIP-Seq_LS180_Human	2.40770361
13	EWS_26573619_Chip-Seq_HEK293_Human	2.40699598
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.40553088
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.39655218
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.36475915
17	FUS_26573619_Chip-Seq_HEK293_Human	2.26889312
18	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.20326568
19	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.91221594
20	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.90493307
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.89626733
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.84689976
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.78062556
24	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.77250265
25	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.75070735
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.72697413
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.71593616
28	P300_19829295_ChIP-Seq_ESCs_Human	1.69800440
29	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.69041710
30	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.67220464
31	RNF2_27304074_Chip-Seq_NSC_Mouse	1.56613311
32	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.53919628
33	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.52578363
34	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.50005167
35	ER_23166858_ChIP-Seq_MCF-7_Human	1.49331617
36	GBX2_23144817_ChIP-Seq_PC3_Human	1.45272832
37	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.44873460
38	BCAT_22108803_ChIP-Seq_LS180_Human	1.43958206
39	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.41887496
40	VDR_23849224_ChIP-Seq_CD4+_Human	1.41132926
41	ELK1_19687146_ChIP-ChIP_HELA_Human	1.41078332
42	MYC_18940864_ChIP-ChIP_HL60_Human	1.39966333
43	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.32818367
44	REST_21632747_ChIP-Seq_MESCs_Mouse	1.32638593
45	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.32493017
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.32300212
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.31768974
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.28990775
49	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.19429513
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18589999
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18589999
52	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.16728772
53	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.16444793
54	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.14817087
55	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.14050721
56	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.12548836
57	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.12269207
58	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.10755544
59	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.09216185
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08811710
61	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.06582173
62	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06169082
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.05518849
64	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.04555182
65	AR_20517297_ChIP-Seq_VCAP_Human	1.04360650
66	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.03051138
67	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.02327535
68	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.01185679
69	IGF1R_20145208_ChIP-Seq_DFB_Human	1.00218444
70	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.98819740
71	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.98033681
72	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.97520139
73	IRF1_19129219_ChIP-ChIP_H3396_Human	0.95076572
74	AR_25329375_ChIP-Seq_VCAP_Human	0.94931446
75	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.94709425
76	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.93962300
77	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.93384208
78	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93336110
79	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.93334377
80	JUN_21703547_ChIP-Seq_K562_Human	0.93101209
81	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.92173507
82	STAT3_23295773_ChIP-Seq_U87_Human	0.92099297
83	SMAD4_21799915_ChIP-Seq_A2780_Human	0.92082943
84	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.91796919
85	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.91318121
86	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.91279189
87	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.91135310
88	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.91077107
89	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.90735436
90	TTF2_22483619_ChIP-Seq_HELA_Human	0.90603361
91	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.90532319
92	RBPJ_21746931_ChIP-Seq_IB4_Human	0.90324094
93	TCF4_22108803_ChIP-Seq_LS180_Human	0.90286740
94	HOXB7_26014856_ChIP-Seq_BT474_Human	0.90104968
95	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.89767859
96	ERA_21632823_ChIP-Seq_H3396_Human	0.88045980
97	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.87415299
98	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.87004027
99	ETV1_20927104_ChIP-Seq_GIST48_Human	0.86934067
100	TCF4_23295773_ChIP-Seq_U87_Human	0.86514567

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.14475859
2	MP0003136_yellow_coat_color	3.06146961
3	MP0001348_abnormal_lacrimal_gland	2.92115830
4	MP0003787_abnormal_imprinting	2.83239848
5	MP0003122_maternal_imprinting	2.79517935
6	MP0008872_abnormal_physiological_respon	2.56287868
7	MP0005084_abnormal_gallbladder_morpholo	2.53469068
8	MP0008875_abnormal_xenobiotic_pharmacok	2.46881453
9	MP0003011_delayed_dark_adaptation	2.46173547
10	MP0006072_abnormal_retinal_apoptosis	2.43261754
11	MP0006276_abnormal_autonomic_nervous	2.42023238
12	MP0006292_abnormal_olfactory_placode	2.40772449
13	MP0004742_abnormal_vestibular_system	2.35855027
14	MP0004885_abnormal_endolymph	2.29229655
15	MP0003878_abnormal_ear_physiology	1.98002584
16	MP0005377_hearing/vestibular/ear_phenot	1.98002584
17	MP0004142_abnormal_muscle_tone	1.93498779
18	MP0002102_abnormal_ear_morphology	1.87607460
19	MP0001873_stomach_inflammation	1.85686413
20	MP0001188_hyperpigmentation	1.82987661
21	MP0001968_abnormal_touch/_nociception	1.82143420
22	MP0002163_abnormal_gland_morphology	1.78011882
23	MP0009379_abnormal_foot_pigmentation	1.76861815
24	MP0002837_dystrophic_cardiac_calcinosis	1.76074789
25	MP0004147_increased_porphyrin_level	1.74923237
26	MP0001529_abnormal_vocalization	1.74192881
27	MP0003121_genomic_imprinting	1.72909025
28	MP0003186_abnormal_redox_activity	1.71351022
29	MP0009745_abnormal_behavioral_response	1.70018497
30	MP0008995_early_reproductive_senescence	1.68786493
31	MP0005551_abnormal_eye_electrophysiolog	1.67543468
32	MP0003880_abnormal_central_pattern	1.67340263
33	MP0001293_anophthalmia	1.65000195
34	MP0008058_abnormal_DNA_repair	1.63076004
35	MP0001485_abnormal_pinna_reflex	1.62595934
36	MP0002557_abnormal_social/conspecific_i	1.58020275
37	MP0005423_abnormal_somatic_nervous	1.57465923
38	MP0002928_abnormal_bile_duct	1.53784302
39	MP0000049_abnormal_middle_ear	1.52138028
40	MP0003195_calcinosis	1.50044424
41	MP0002272_abnormal_nervous_system	1.49206642
42	MP0009046_muscle_twitch	1.46713612
43	MP0001905_abnormal_dopamine_level	1.44213370
44	MP0002638_abnormal_pupillary_reflex	1.42743789
45	MP0001984_abnormal_olfaction	1.39188031
46	MP0005253_abnormal_eye_physiology	1.39101214
47	MP0002909_abnormal_adrenal_gland	1.34999267
48	MP0005171_absent_coat_pigmentation	1.32694979
49	MP0002736_abnormal_nociception_after	1.32364684
50	MP0002938_white_spotting	1.31569421
51	MP0005645_abnormal_hypothalamus_physiol	1.31414474
52	MP0001502_abnormal_circadian_rhythm	1.30406925
53	MP0000569_abnormal_digit_pigmentation	1.30118986
54	MP0002572_abnormal_emotion/affect_behav	1.29864024
55	MP0002822_catalepsy	1.28863756
56	MP0006035_abnormal_mitochondrial_morpho	1.26329663
57	MP0005379_endocrine/exocrine_gland_phen	1.22099314
58	MP0005646_abnormal_pituitary_gland	1.21194777
59	MP0002277_abnormal_respiratory_mucosa	1.20184383
60	MP0005174_abnormal_tail_pigmentation	1.18634928
61	MP0000631_abnormal_neuroendocrine_gland	1.16319852
62	MP0005195_abnormal_posterior_eye	1.10236490
63	MP0001970_abnormal_pain_threshold	1.08643804
64	MP0004133_heterotaxia	1.08491717
65	MP0001486_abnormal_startle_reflex	1.03633354
66	MP0000778_abnormal_nervous_system	1.01885396
67	MP0004145_abnormal_muscle_electrophysio	1.01588416
68	MP0001963_abnormal_hearing_physiology	0.98348305
69	MP0002138_abnormal_hepatobiliary_system	0.97266938
70	MP0002752_abnormal_somatic_nervous	0.96469129
71	MP0003283_abnormal_digestive_organ	0.96135316
72	MP0000026_abnormal_inner_ear	0.95706240
73	MP0005391_vision/eye_phenotype	0.95216188
74	MP0002064_seizures	0.94681270
75	MP0003119_abnormal_digestive_system	0.94477412
76	MP0001440_abnormal_grooming_behavior	0.92300655
77	MP0005503_abnormal_tendon_morphology	0.91591062
78	MP0002067_abnormal_sensory_capabilities	0.91077066
79	MP0002184_abnormal_innervation	0.90984413
80	MP0002735_abnormal_chemical_nociception	0.90858180
81	MP0005085_abnormal_gallbladder_physiolo	0.90401697
82	MP0004924_abnormal_behavior	0.89553872
83	MP0005386_behavior/neurological_phenoty	0.89553872
84	MP0003786_premature_aging	0.89176124
85	MP0002693_abnormal_pancreas_physiology	0.88957559
86	MP0003937_abnormal_limbs/digits/tail_de	0.85747447
87	MP0002734_abnormal_mechanical_nocicepti	0.83332397
88	MP0010386_abnormal_urinary_bladder	0.83053470
89	MP0002095_abnormal_skin_pigmentation	0.82986891
90	MP0005389_reproductive_system_phenotype	0.81548182
91	MP0002733_abnormal_thermal_nociception	0.79836957
92	MP0004019_abnormal_vitamin_homeostasis	0.78085967
93	MP0001324_abnormal_eye_pigmentation	0.77364254
94	MP0001986_abnormal_taste_sensitivity	0.76996709
95	MP0003938_abnormal_ear_development	0.75315508
96	MP0002063_abnormal_learning/memory/cond	0.73338181
97	MP0002210_abnormal_sex_determination	0.71648305
98	MP0008789_abnormal_olfactory_epithelium	0.70828125
99	MP0002249_abnormal_larynx_morphology	0.68117796
100	MP0001929_abnormal_gametogenesis	0.67935237

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	4.03886641
2	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.94643826
3	Abnormality of the labia minora (HP:0012880)	3.77393849
4	Abnormal respiratory epithelium morphology (HP:0012253)	3.73819078
5	Abnormal respiratory motile cilium morphology (HP:0005938)	3.73819078
6	Acute necrotizing encephalopathy (HP:0006965)	3.61103007
7	Abnormality of cells of the erythroid lineage (HP:0012130)	3.37891468
8	Decreased central vision (HP:0007663)	3.36599253
9	Congenital sensorineural hearing impairment (HP:0008527)	3.24279668
10	Supernumerary spleens (HP:0009799)	3.22798891
11	Pancreatic fibrosis (HP:0100732)	3.22768676
12	Fibular aplasia (HP:0002990)	3.21436702
13	Reticulocytopenia (HP:0001896)	3.12839606
14	Acute encephalopathy (HP:0006846)	3.10157078
15	Pendular nystagmus (HP:0012043)	3.08649660
16	Progressive macrocephaly (HP:0004481)	3.07688037
17	True hermaphroditism (HP:0010459)	3.07112719
18	Abnormal rod and cone electroretinograms (HP:0008323)	3.03593061
19	Short tibia (HP:0005736)	2.99706166
20	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.87678094
21	Macrocytic anemia (HP:0001972)	2.84775508
22	Pancreatic cysts (HP:0001737)	2.84361607
23	Fibular hypoplasia (HP:0003038)	2.83612153
24	Mitochondrial inheritance (HP:0001427)	2.82951761
25	Abnormal ciliary motility (HP:0012262)	2.82117166
26	Abnormal mitochondria in muscle tissue (HP:0008316)	2.80896553
27	Abnormality of midbrain morphology (HP:0002418)	2.73783187
28	Molar tooth sign on MRI (HP:0002419)	2.73783187
29	3-Methylglutaconic aciduria (HP:0003535)	2.71334647
30	Abnormal number of erythroid precursors (HP:0012131)	2.69756527
31	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.63776556
32	Increased CSF lactate (HP:0002490)	2.62176785
33	Increased hepatocellular lipid droplets (HP:0006565)	2.58673847
34	Congenital, generalized hypertrichosis (HP:0004540)	2.57423499
35	Medial flaring of the eyebrow (HP:0010747)	2.57318114
36	Hyperglycinemia (HP:0002154)	2.50102878
37	Lipid accumulation in hepatocytes (HP:0006561)	2.49561786
38	Increased corneal curvature (HP:0100692)	2.44928196
39	Keratoconus (HP:0000563)	2.44928196
40	Abnormality of the renal cortex (HP:0011035)	2.43634059
41	Optic disc pallor (HP:0000543)	2.42523913
42	Gait imbalance (HP:0002141)	2.39430552
43	Hemiparesis (HP:0001269)	2.38471250
44	Birth length less than 3rd percentile (HP:0003561)	2.37059329
45	Congenital primary aphakia (HP:0007707)	2.36332838
46	Retinal dysplasia (HP:0007973)	2.35420542
47	Renal cortical cysts (HP:0000803)	2.34842504
48	Methylmalonic acidemia (HP:0002912)	2.29529915
49	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.28218208
50	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.23656992
51	Absent/shortened dynein arms (HP:0200106)	2.23656992
52	Congenital stationary night blindness (HP:0007642)	2.22926492
53	Asplenia (HP:0001746)	2.20408794
54	Bony spicule pigmentary retinopathy (HP:0007737)	2.19219062
55	Lissencephaly (HP:0001339)	2.17427700
56	Abnormal respiratory motile cilium physiology (HP:0012261)	2.17130345
57	Large for gestational age (HP:0001520)	2.11757388
58	Attenuation of retinal blood vessels (HP:0007843)	2.09040227
59	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.07144427
60	Hypoplasia of the fovea (HP:0007750)	2.07144427
61	Hypoglycemic coma (HP:0001325)	2.05446276
62	Nephrogenic diabetes insipidus (HP:0009806)	2.05431347
63	Oligodactyly (HP:0012165)	2.05328432
64	Cerebral edema (HP:0002181)	2.04853556
65	Oligodactyly (hands) (HP:0001180)	2.02883204
66	Cystic liver disease (HP:0006706)	2.01474242
67	Nephronophthisis (HP:0000090)	1.98302517
68	Inability to walk (HP:0002540)	1.97280544
69	Abnormality of lateral ventricle (HP:0030047)	1.97191478
70	Male pseudohermaphroditism (HP:0000037)	1.95123905
71	Increased serum lactate (HP:0002151)	1.92845895
72	Pallor (HP:0000980)	1.92271431
73	Hepatic necrosis (HP:0002605)	1.91299351
74	Respiratory failure (HP:0002878)	1.89950058
75	Methylmalonic aciduria (HP:0012120)	1.89713696
76	Chronic sinusitis (HP:0011109)	1.89492927
77	Respiratory distress (HP:0002098)	1.87013240
78	Febrile seizures (HP:0002373)	1.86984559
79	Pachygyria (HP:0001302)	1.86228770
80	Colon cancer (HP:0003003)	1.86047320
81	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.85622092
82	Abnormality of alanine metabolism (HP:0010916)	1.85622092
83	Hyperalaninemia (HP:0003348)	1.85622092
84	Concave nail (HP:0001598)	1.83731855
85	Hyperventilation (HP:0002883)	1.81745501
86	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.81341346
87	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.81268089
88	Genital tract atresia (HP:0001827)	1.80162424
89	Testicular atrophy (HP:0000029)	1.79246633
90	Bile duct proliferation (HP:0001408)	1.78536764
91	Abnormal biliary tract physiology (HP:0012439)	1.78536764
92	Hypoplasia of the ulna (HP:0003022)	1.77716588
93	Impulsivity (HP:0100710)	1.77439744
94	Abnormality of the renal medulla (HP:0100957)	1.76359600
95	Abolished electroretinogram (ERG) (HP:0000550)	1.73512585
96	Abnormality of urine glucose concentration (HP:0011016)	1.73479108
97	Glycosuria (HP:0003076)	1.73479108
98	Anencephaly (HP:0002323)	1.69542153
99	Poor coordination (HP:0002370)	1.69398013
100	Septo-optic dysplasia (HP:0100842)	1.69274189

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TSSK6	4.53892293
2	MAPK15	3.58957216
3	VRK2	2.70693573
4	MKNK2	2.61340752
5	EIF2AK1	2.59107995
6	FRK	2.58580320
7	CASK	2.42652010
8	MAPKAPK5	2.40433348
9	TAOK3	2.34702518
10	DYRK2	2.33427486
11	PNCK	2.16965231
12	TAF1	2.15279481
13	TYRO3	2.10174991
14	VRK1	2.09935977
15	ZAK	1.96844351
16	ADRBK2	1.89355694
17	CAMKK2	1.87952179
18	PASK	1.86005239
19	MAP4K2	1.83237896
20	GRK1	1.70731773
21	PBK	1.67635476
22	MKNK1	1.51239824
23	TLK1	1.49749702
24	WNK4	1.48351798
25	PLK3	1.34515073
26	EIF2AK3	1.32845161
27	CSNK1G2	1.29341281
28	STK39	1.28818492
29	TNIK	1.24287000
30	INSRR	1.24187106
31	PHKG2	1.21622672
32	PHKG1	1.21622672
33	STK16	1.19296588
34	AKT3	1.15959959
35	WNK3	1.15920603
36	NTRK3	1.15909228
37	CSNK1A1L	1.15890654
38	MAP3K12	1.15545261
39	CSNK1G3	1.12994842
40	MAPKAPK3	1.05686529
41	NUAK1	1.00334122
42	PRKCG	0.97774754
43	OXSR1	0.94656177
44	CSNK1G1	0.91691838
45	TGFBR1	0.87680626
46	KSR1	0.84881014
47	DYRK3	0.83894113
48	NLK	0.83230244
49	MAP3K11	0.82244017
50	PLK4	0.78859190
51	LRRK2	0.76231774
52	BRSK2	0.74673673
53	BCKDK	0.72715210
54	WEE1	0.71830709
55	PLK2	0.68280294
56	DDR2	0.64280079
57	MAPK13	0.60962233
58	BMPR1B	0.60505588
59	DAPK3	0.60186711
60	ADRBK1	0.58260141
61	PRKCE	0.56726970
62	EIF2AK2	0.55480075
63	STK4	0.53193427
64	RPS6KB2	0.52876065
65	CAMK1D	0.52819386
66	STK38L	0.52486481
67	CAMK2D	0.52200313
68	PINK1	0.51845558
69	CSNK1E	0.51757184
70	ITK	0.50481468
71	EPHA4	0.50230264
72	MARK1	0.50159936
73	DAPK2	0.48561988
74	FES	0.48110193
75	MATK	0.45658556
76	BCR	0.44765930
77	GRK5	0.44052672
78	KIT	0.44050204
79	STK11	0.43674772
80	PRKACA	0.42545030
81	STK3	0.39519646
82	CSNK1A1	0.39321383
83	MAP2K4	0.39001541
84	STK24	0.38566453
85	PKN1	0.38095621
86	SGK1	0.37462635
87	EPHB2	0.37367147
88	CSNK2A2	0.35676419
89	NME1	0.35095372
90	BUB1	0.34069610
91	TIE1	0.33222607
92	OBSCN	0.32546315
93	PRKACB	0.32389753
94	CSNK2A1	0.31688486
95	PIK3CG	0.31652848
96	GRK7	0.31284793
97	ALK	0.31092357
98	PAK3	0.30746991
99	CAMK1G	0.30699363
100	PRKG1	0.30297308

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.71195975
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.56959799
3	Protein export_Homo sapiens_hsa03060	3.51636410
4	Parkinsons disease_Homo sapiens_hsa05012	3.07048717
5	Cardiac muscle contraction_Homo sapiens_hsa04260	2.66904330
6	One carbon pool by folate_Homo sapiens_hsa00670	2.46553991
7	RNA polymerase_Homo sapiens_hsa03020	2.27401059
8	Basal transcription factors_Homo sapiens_hsa03022	2.10540691
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.04962704
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.03086165
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.01400107
12	Butanoate metabolism_Homo sapiens_hsa00650	1.97991151
13	Huntingtons disease_Homo sapiens_hsa05016	1.96076409
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.89489827
15	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.86626658
16	Alzheimers disease_Homo sapiens_hsa05010	1.86476275
17	Proteasome_Homo sapiens_hsa03050	1.85307042
18	Asthma_Homo sapiens_hsa05310	1.82072198
19	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.81611146
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.70961754
21	RNA degradation_Homo sapiens_hsa03018	1.60486530
22	Nicotine addiction_Homo sapiens_hsa05033	1.53935490
23	Caffeine metabolism_Homo sapiens_hsa00232	1.42829450
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.35932344
25	Allograft rejection_Homo sapiens_hsa05330	1.33436934
26	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.31977933
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.31755336
28	Circadian rhythm_Homo sapiens_hsa04710	1.27753999
29	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.21653940
30	Chemical carcinogenesis_Homo sapiens_hsa05204	1.20355363
31	Non-homologous end-joining_Homo sapiens_hsa03450	1.19675339
32	Nucleotide excision repair_Homo sapiens_hsa03420	1.08186487
33	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.08059093
34	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.07582695
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.04471805
36	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.03448143
37	Homologous recombination_Homo sapiens_hsa03440	1.02830904
38	Mismatch repair_Homo sapiens_hsa03430	1.01361285
39	Glutathione metabolism_Homo sapiens_hsa00480	1.00729408
40	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.99384847
41	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.97091947
42	Phototransduction_Homo sapiens_hsa04744	0.96603056
43	Purine metabolism_Homo sapiens_hsa00230	0.92907662
44	Propanoate metabolism_Homo sapiens_hsa00640	0.91934106
45	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.91771484
46	Olfactory transduction_Homo sapiens_hsa04740	0.91033921
47	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.89749605
48	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.88306276
49	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.87255157
50	Spliceosome_Homo sapiens_hsa03040	0.86725636
51	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.85156423
52	Peroxisome_Homo sapiens_hsa04146	0.84406450
53	Ether lipid metabolism_Homo sapiens_hsa00565	0.84258306
54	Tryptophan metabolism_Homo sapiens_hsa00380	0.83407549
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.83040055
56	Steroid biosynthesis_Homo sapiens_hsa00100	0.80793417
57	Basal cell carcinoma_Homo sapiens_hsa05217	0.80273560
58	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.79783950
59	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.79414812
60	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.77891269
61	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.77244299
62	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.75952091
63	Morphine addiction_Homo sapiens_hsa05032	0.75489627
64	RNA transport_Homo sapiens_hsa03013	0.75018953
65	Glutamatergic synapse_Homo sapiens_hsa04724	0.71815865
66	Retinol metabolism_Homo sapiens_hsa00830	0.71373742
67	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.68174920
68	Pyrimidine metabolism_Homo sapiens_hsa00240	0.65947868
69	Collecting duct acid secretion_Homo sapiens_hsa04966	0.65941566
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.65798799
71	Selenocompound metabolism_Homo sapiens_hsa00450	0.62988012
72	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.60284697
73	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.59505598
74	Insulin secretion_Homo sapiens_hsa04911	0.59186950
75	Serotonergic synapse_Homo sapiens_hsa04726	0.58135085
76	Metabolic pathways_Homo sapiens_hsa01100	0.55248692
77	Circadian entrainment_Homo sapiens_hsa04713	0.52918484
78	Taste transduction_Homo sapiens_hsa04742	0.51015893
79	GABAergic synapse_Homo sapiens_hsa04727	0.50719001
80	Sulfur metabolism_Homo sapiens_hsa00920	0.48769201
81	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.47728722
82	DNA replication_Homo sapiens_hsa03030	0.47535104
83	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.45696535
84	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.42745821
85	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40376208
86	Salivary secretion_Homo sapiens_hsa04970	0.40171343
87	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.39775392
88	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.38246937
89	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.36565146
90	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.31761729
91	Primary immunodeficiency_Homo sapiens_hsa05340	0.29260705
92	Type I diabetes mellitus_Homo sapiens_hsa04940	0.28743743
93	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.28017175
94	Mineral absorption_Homo sapiens_hsa04978	0.26996206
95	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.26628523
96	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.26303127
97	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.25795753
98	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.24480399
99	Long-term depression_Homo sapiens_hsa04730	0.23770692
100	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.23318225

RPL23P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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