ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.97640372
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.72152730
3	piRNA metabolic process (GO:0034587)	5.34596268
4	L-fucose metabolic process (GO:0042354)	5.17582897
5	L-fucose catabolic process (GO:0042355)	5.17582897
6	fucose catabolic process (GO:0019317)	5.17582897
7	GTP biosynthetic process (GO:0006183)	4.30252637
8	ubiquinone biosynthetic process (GO:0006744)	3.95814255
9	DNA methylation involved in gamete generation (GO:0043046)	3.94529519
10	UTP biosynthetic process (GO:0006228)	3.90185936
11	organic cation transport (GO:0015695)	3.82883085
12	UTP metabolic process (GO:0046051)	3.80423363
13	positive regulation of natural killer cell differentiation (GO:0032825)	3.78879861
14	negative regulation of telomere maintenance (GO:0032205)	3.62903694
15	mast cell activation (GO:0045576)	3.62275304
16	rRNA modification (GO:0000154)	3.59025742
17	ubiquinone metabolic process (GO:0006743)	3.46031248
18	ribosomal small subunit assembly (GO:0000028)	3.45685850
19	cellular response to interleukin-15 (GO:0071350)	3.39199111
20	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.38853945
21	isotype switching (GO:0045190)	3.38853945
22	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.38853945
23	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.29395996
24	ATP synthesis coupled proton transport (GO:0015986)	3.29395996
25	interferon-gamma production (GO:0032609)	3.27235975
26	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.25617133
27	cytidine deamination (GO:0009972)	3.20231664
28	cytidine metabolic process (GO:0046087)	3.20231664
29	cytidine catabolic process (GO:0006216)	3.20231664
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.18815835
31	NADH dehydrogenase complex assembly (GO:0010257)	3.18815835
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.18815835
33	mast cell degranulation (GO:0043303)	3.16014162
34	mast cell activation involved in immune response (GO:0002279)	3.16014162
35	quinone biosynthetic process (GO:1901663)	3.14278289
36	protein complex biogenesis (GO:0070271)	3.13586353
37	regulation of thymocyte apoptotic process (GO:0070243)	3.08322865
38	respiratory chain complex IV assembly (GO:0008535)	3.07635018
39	water-soluble vitamin biosynthetic process (GO:0042364)	3.07451840
40	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	3.07352240
41	cellular response to exogenous dsRNA (GO:0071360)	3.06539263
42	antigen processing and presentation via MHC class Ib (GO:0002475)	3.05369448
43	regulation of immunoglobulin secretion (GO:0051023)	3.04548818
44	nucleoside diphosphate phosphorylation (GO:0006165)	3.03623071
45	pyrimidine ribonucleoside metabolic process (GO:0046131)	3.01247190
46	maturation of 5.8S rRNA (GO:0000460)	3.00702165
47	behavioral response to nicotine (GO:0035095)	3.00086348
48	CTP biosynthetic process (GO:0006241)	2.98934554
49	CTP metabolic process (GO:0046036)	2.98934554
50	rRNA methylation (GO:0031167)	2.94216667
51	response to interleukin-15 (GO:0070672)	2.94109680
52	mitochondrial respiratory chain complex assembly (GO:0033108)	2.93821997
53	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.91724564
54	morphogenesis of an endothelium (GO:0003159)	2.91525945
55	endothelial tube morphogenesis (GO:0061154)	2.91525945
56	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.90758295
57	protein-cofactor linkage (GO:0018065)	2.90258620
58	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	2.88574957
59	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.88471569
60	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.88408964
61	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.85029407
62	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.85029407
63	fucosylation (GO:0036065)	2.84649995
64	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.84110397
65	sleep (GO:0030431)	2.82913626
66	guanosine-containing compound biosynthetic process (GO:1901070)	2.82783626
67	positive regulation of prostaglandin secretion (GO:0032308)	2.80277885
68	somatic diversification of immunoglobulins (GO:0016445)	2.80130655
69	positive regulation of fatty acid transport (GO:2000193)	2.78380368
70	pyrimidine ribonucleotide metabolic process (GO:0009218)	2.77927027
71	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.77292941
72	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.76041203
73	cytochrome complex assembly (GO:0017004)	2.75740689
74	termination of RNA polymerase I transcription (GO:0006363)	2.74636299
75	indolalkylamine metabolic process (GO:0006586)	2.73689125
76	regulation of defense response to virus by host (GO:0050691)	2.72588748
77	tolerance induction (GO:0002507)	2.72293738
78	cytokine biosynthetic process (GO:0042089)	2.70286628
79	regulation of germinal center formation (GO:0002634)	2.69665793
80	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.69584528
81	regulation of natural killer cell differentiation (GO:0032823)	2.67260651
82	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.66073864
83	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.63535707
84	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.62997083
85	pyrimidine nucleotide biosynthetic process (GO:0006221)	2.60964972
86	metallo-sulfur cluster assembly (GO:0031163)	2.60032973
87	iron-sulfur cluster assembly (GO:0016226)	2.60032973
88	indole-containing compound catabolic process (GO:0042436)	2.58965157
89	indolalkylamine catabolic process (GO:0046218)	2.58965157
90	tryptophan catabolic process (GO:0006569)	2.58965157
91	response to interferon-beta (GO:0035456)	2.58935184
92	preassembly of GPI anchor in ER membrane (GO:0016254)	2.57251553
93	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.55750894
94	male meiosis (GO:0007140)	2.54689713
95	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.54017382
96	cullin deneddylation (GO:0010388)	2.53350080
97	protein deneddylation (GO:0000338)	2.53041274
98	positive regulation of defense response to virus by host (GO:0002230)	2.52824085
99	kynurenine metabolic process (GO:0070189)	2.52750953
100	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.48844391

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	4.23533203
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.41354031
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.33766230
4	VDR_22108803_ChIP-Seq_LS180_Human	3.25062341
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.19327801
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.89661603
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.86973946
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.71183236
9	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.64572493
10	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.58757205
11	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.45768699
12	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.41588513
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.35997786
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.24150986
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.22923161
16	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.22347210
17	ZNF274_21170338_ChIP-Seq_K562_Hela	2.21551068
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.10199449
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.09927863
20	IGF1R_20145208_ChIP-Seq_DFB_Human	2.09086152
21	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.08395408
22	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.07255371
23	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.04471673
24	GATA3_26560356_Chip-Seq_TH2_Human	2.00392141
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.98714372
26	RUNX_20019798_ChIP-Seq_JUKART_Human	1.97053635
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.83732587
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.81035369
29	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.80660532
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.79932358
31	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.79103139
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.76308572
33	EZH2_22144423_ChIP-Seq_EOC_Human	1.69578332
34	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.66335947
35	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.66269223
36	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.63237897
37	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.60168523
38	ELK1_19687146_ChIP-ChIP_HELA_Human	1.56250667
39	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.55789468
40	MYC_18940864_ChIP-ChIP_HL60_Human	1.55258613
41	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.53156073
42	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.53056517
43	IRF1_19129219_ChIP-ChIP_H3396_Human	1.41892006
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.39093352
45	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.38809446
46	MYB_26560356_Chip-Seq_TH2_Human	1.36512917
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.34488425
48	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.33733272
49	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.32680811
50	ER_23166858_ChIP-Seq_MCF-7_Human	1.29853080
51	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.29307898
52	HOXB7_26014856_ChIP-Seq_BT474_Human	1.27841041
53	STAT1_20625510_ChIP-Seq_HELA_Human	1.27073293
54	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.23771066
55	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.17928072
56	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.17609689
57	TAF2_19829295_ChIP-Seq_ESCs_Human	1.16702157
58	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.15314587
59	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.14815941
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13877636
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13877636
62	AR_20517297_ChIP-Seq_VCAP_Human	1.11747805
63	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.11454085
64	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10371147
65	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.06923753
66	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.06695774
67	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.06143237
68	P300_19829295_ChIP-Seq_ESCs_Human	1.03031099
69	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.00625075
70	ERA_21632823_ChIP-Seq_H3396_Human	0.99946115
71	EWS_26573619_Chip-Seq_HEK293_Human	0.98958293
72	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.98814335
73	TCF4_22108803_ChIP-Seq_LS180_Human	0.98414045
74	SOX2_19829295_ChIP-Seq_ESCs_Human	0.98400319
75	NANOG_19829295_ChIP-Seq_ESCs_Human	0.98400319
76	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97309199
77	NCOR_22424771_ChIP-Seq_293T_Human	0.97227893
78	GATA3_27048872_Chip-Seq_THYMUS_Human	0.97120102
79	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.96891354
80	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.96396469
81	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.95781980
82	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.93881300
83	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.92439329
84	NANOG_20526341_ChIP-Seq_ESCs_Human	0.90884112
85	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.89432039
86	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.89333513
87	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.89004000
88	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.88582056
89	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.88428034
90	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.86237120
91	CDX2_22108803_ChIP-Seq_LS180_Human	0.86086027
92	TTF2_22483619_ChIP-Seq_HELA_Human	0.86068117
93	RBPJ_21746931_ChIP-Seq_IB4_Human	0.85542385
94	GATA3_26560356_Chip-Seq_TH1_Human	0.84898420
95	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.84435592
96	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.83967893
97	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.83094208
98	TCF4_23295773_ChIP-Seq_U87_Human	0.82518310
99	BCAT_22108803_ChIP-Seq_LS180_Human	0.82052104
100	P53_21459846_ChIP-Seq_SAOS-2_Human	0.81851382

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002138_abnormal_hepatobiliary_system	4.68621627
2	MP0000685_abnormal_immune_system	4.03261888
3	MP0005671_abnormal_response_to	3.92698237
4	MP0001835_abnormal_antigen_presentation	3.63157508
5	MP0006054_spinal_hemorrhage	3.01963492
6	MP0002102_abnormal_ear_morphology	2.80999212
7	MP0008877_abnormal_DNA_methylation	2.75107534
8	MP0004147_increased_porphyrin_level	2.67935509
9	MP0001790_abnormal_immune_system	2.49146997
10	MP0005387_immune_system_phenotype	2.49146997
11	MP0006072_abnormal_retinal_apoptosis	2.34129385
12	MP0005084_abnormal_gallbladder_morpholo	2.22760124
13	MP0001800_abnormal_humoral_immune	2.22607764
14	MP0003195_calcinosis	2.21930088
15	MP0008875_abnormal_xenobiotic_pharmacok	2.20640252
16	MP0002148_abnormal_hypersensitivity_rea	2.02611361
17	MP0003646_muscle_fatigue	1.91658937
18	MP0001873_stomach_inflammation	1.90543629
19	MP0005167_abnormal_blood-brain_barrier	1.83131914
20	MP0003724_increased_susceptibility_to	1.79147645
21	MP0003183_abnormal_peptide_metabolism	1.70928649
22	MP0005000_abnormal_immune_tolerance	1.70810007
23	MP0000569_abnormal_digit_pigmentation	1.70438260
24	MP0005551_abnormal_eye_electrophysiolog	1.60907462
25	MP0002723_abnormal_immune_serum	1.57971997
26	MP0001968_abnormal_touch/_nociception	1.57112575
27	MP0008872_abnormal_physiological_respon	1.56476490
28	MP0009379_abnormal_foot_pigmentation	1.51923548
29	MP0009785_altered_susceptibility_to	1.49571660
30	MP0005360_urolithiasis	1.49437332
31	MP0003436_decreased_susceptibility_to	1.48291981
32	MP0002638_abnormal_pupillary_reflex	1.46047937
33	MP0005085_abnormal_gallbladder_physiolo	1.44323434
34	MP0002876_abnormal_thyroid_physiology	1.43288622
35	MP0004043_abnormal_pH_regulation	1.40452839
36	MP0002452_abnormal_antigen_presenting	1.39933771
37	MP0005646_abnormal_pituitary_gland	1.37132067
38	MP0001819_abnormal_immune_cell	1.35073274
39	MP0009764_decreased_sensitivity_to	1.34888970
40	MP0002420_abnormal_adaptive_immunity	1.34451595
41	MP0005075_abnormal_melanosome_morpholog	1.33194143
42	MP0004885_abnormal_endolymph	1.32541760
43	MP0004145_abnormal_muscle_electrophysio	1.31489570
44	MP0002933_joint_inflammation	1.31372092
45	MP0003786_premature_aging	1.30067194
46	MP0003252_abnormal_bile_duct	1.25252036
47	MP0006292_abnormal_olfactory_placode	1.24753564
48	MP0009333_abnormal_splenocyte_physiolog	1.24078311
49	MP0003763_abnormal_thymus_physiology	1.23953000
50	MP0005253_abnormal_eye_physiology	1.20963461
51	MP0002166_altered_tumor_susceptibility	1.20551276
52	MP0003567_abnormal_fetal_cardiomyocyte	1.17392029
53	MP0005025_abnormal_response_to	1.16243335
54	MP0003806_abnormal_nucleotide_metabolis	1.16234576
55	MP0005367_renal/urinary_system_phenotyp	1.14856505
56	MP0000516_abnormal_urinary_system	1.14856505
57	MP0004742_abnormal_vestibular_system	1.14265445
58	MP0001501_abnormal_sleep_pattern	1.12924208
59	MP0002006_tumorigenesis	1.12121692
60	MP0001905_abnormal_dopamine_level	1.12010356
61	MP0005365_abnormal_bile_salt	1.09688632
62	MP0000613_abnormal_salivary_gland	1.08908899
63	MP0000465_gastrointestinal_hemorrhage	1.05406955
64	MP0002736_abnormal_nociception_after	1.04731452
65	MP0002254_reproductive_system_inflammat	1.04374336
66	MP0000689_abnormal_spleen_morphology	1.03751994
67	MP0002398_abnormal_bone_marrow	1.00447103
68	MP0000703_abnormal_thymus_morphology	1.00051732
69	MP0010155_abnormal_intestine_physiology	0.97489534
70	MP0001845_abnormal_inflammatory_respons	0.95847017
71	MP0000716_abnormal_immune_system	0.95304731
72	MP0008058_abnormal_DNA_repair	0.94466500
73	MP0004142_abnormal_muscle_tone	0.90920885
74	MP0001919_abnormal_reproductive_system	0.88467281
75	MP0002405_respiratory_system_inflammati	0.88302462
76	MP0002396_abnormal_hematopoietic_system	0.86339963
77	MP0005174_abnormal_tail_pigmentation	0.86238471
78	MP0002938_white_spotting	0.84415467
79	MP0005408_hypopigmentation	0.82890158
80	MP0001663_abnormal_digestive_system	0.82682773
81	MP0003329_amyloid_beta_deposits	0.82625361
82	MP0002928_abnormal_bile_duct	0.82246197
83	MP0001533_abnormal_skeleton_physiology	0.81781368
84	MP0002722_abnormal_immune_system	0.81502318
85	MP0001986_abnormal_taste_sensitivity	0.81097547
86	MP0005377_hearing/vestibular/ear_phenot	0.80066852
87	MP0003878_abnormal_ear_physiology	0.80066852
88	MP0008775_abnormal_heart_ventricle	0.76453248
89	MP0006036_abnormal_mitochondrial_physio	0.73914786
90	MP0003011_delayed_dark_adaptation	0.73864328
91	MP0002429_abnormal_blood_cell	0.71510400
92	MP0002837_dystrophic_cardiac_calcinosis	0.69799162
93	MP0008995_early_reproductive_senescence	0.69746832
94	MP0005636_abnormal_mineral_homeostasis	0.69166175
95	MP0001485_abnormal_pinna_reflex	0.67173192
96	MP0003866_abnormal_defecation	0.66350855
97	MP0005332_abnormal_amino_acid	0.66297859
98	MP0004133_heterotaxia	0.64755684
99	MP0000631_abnormal_neuroendocrine_gland	0.63513617
100	MP0003693_abnormal_embryo_hatching	0.62715765

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Stomatitis (HP:0010280)	6.23328607
2	Elevated erythrocyte sedimentation rate (HP:0003565)	4.68528972
3	IgG deficiency (HP:0004315)	4.57285648
4	Pancreatic cysts (HP:0001737)	3.95214050
5	Congenital, generalized hypertrichosis (HP:0004540)	3.88895023
6	Prostate neoplasm (HP:0100787)	3.80340213
7	Abnormality of midbrain morphology (HP:0002418)	3.38898326
8	Molar tooth sign on MRI (HP:0002419)	3.38898326
9	Congenital stationary night blindness (HP:0007642)	3.36431647
10	Abnormal number of erythroid precursors (HP:0012131)	3.30970653
11	Abnormal biliary tract physiology (HP:0012439)	3.26329383
12	Bile duct proliferation (HP:0001408)	3.26329383
13	Pancreatic fibrosis (HP:0100732)	3.14183798
14	Abnormality of cells of the erythroid lineage (HP:0012130)	3.12677283
15	Type II lissencephaly (HP:0007260)	3.10286386
16	Abnormality of the prostate (HP:0008775)	3.08722891
17	Abnormal rod and cone electroretinograms (HP:0008323)	3.06765523
18	Increased IgM level (HP:0003496)	3.06515566
19	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.99261358
20	Absent/shortened dynein arms (HP:0200106)	2.99261358
21	Abolished electroretinogram (ERG) (HP:0000550)	2.95425527
22	True hermaphroditism (HP:0010459)	2.90023478
23	Mitochondrial inheritance (HP:0001427)	2.85023887
24	Stomach cancer (HP:0012126)	2.83864876
25	Nephronophthisis (HP:0000090)	2.83274564
26	Hepatocellular necrosis (HP:0001404)	2.81438638
27	Abnormality of the renal cortex (HP:0011035)	2.80367082
28	Increased hepatocellular lipid droplets (HP:0006565)	2.79270241
29	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.74157430
30	Acute necrotizing encephalopathy (HP:0006965)	2.72529461
31	Myositis (HP:0100614)	2.69737650
32	Increased CSF lactate (HP:0002490)	2.64944040
33	Pancytopenia (HP:0001876)	2.62650198
34	Renal cortical cysts (HP:0000803)	2.60598640
35	Keratoconus (HP:0000563)	2.59244039
36	Increased corneal curvature (HP:0100692)	2.59244039
37	Acute encephalopathy (HP:0006846)	2.58688965
38	Hepatic necrosis (HP:0002605)	2.57830653
39	Lipid accumulation in hepatocytes (HP:0006561)	2.57736204
40	Colon cancer (HP:0003003)	2.53949488
41	Hypoproteinemia (HP:0003075)	2.50286333
42	Abnormality of T cell physiology (HP:0011840)	2.48944909
43	Abnormal drinking behavior (HP:0030082)	2.43484914
44	Polydipsia (HP:0001959)	2.43484914
45	Progressive macrocephaly (HP:0004481)	2.43200456
46	Dry hair (HP:0011359)	2.43070270
47	Cystic liver disease (HP:0006706)	2.36781661
48	Abnormality of the renal medulla (HP:0100957)	2.36563801
49	Severe combined immunodeficiency (HP:0004430)	2.26019010
50	Alveolar cell carcinoma (HP:0006519)	2.25181648
51	Abnormal mitochondria in muscle tissue (HP:0008316)	2.21222020
52	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.20040736
53	Type 2 muscle fiber atrophy (HP:0003554)	2.19821320
54	Hyperglycinuria (HP:0003108)	2.16801962
55	Decreased central vision (HP:0007663)	2.16759096
56	Congenital hepatic fibrosis (HP:0002612)	2.16328726
57	Abnormality of T cells (HP:0002843)	2.16010994
58	Neoplasm of the adrenal cortex (HP:0100641)	2.13610785
59	Sclerocornea (HP:0000647)	2.07778775
60	Abnormal respiratory epithelium morphology (HP:0012253)	2.06090821
61	Abnormal respiratory motile cilium morphology (HP:0005938)	2.06090821
62	Asplenia (HP:0001746)	2.05850210
63	Panhypogammaglobulinemia (HP:0003139)	2.05658397
64	Severe muscular hypotonia (HP:0006829)	2.03183985
65	Conical tooth (HP:0000698)	2.02745535
66	Cerebellar dysplasia (HP:0007033)	2.02494046
67	Methylmalonic acidemia (HP:0002912)	1.98969018
68	Increased serum lactate (HP:0002151)	1.98498331
69	Fair hair (HP:0002286)	1.97646504
70	Anencephaly (HP:0002323)	1.94534711
71	Porencephaly (HP:0002132)	1.93479847
72	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.93292341
73	Lactic acidosis (HP:0003128)	1.93206142
74	Neonatal respiratory distress (HP:0002643)	1.93054663
75	Tubular atrophy (HP:0000092)	1.91185255
76	Increased intramyocellular lipid droplets (HP:0012240)	1.89925344
77	Testicular atrophy (HP:0000029)	1.88459836
78	Medial flaring of the eyebrow (HP:0010747)	1.87979577
79	Abnormality of male internal genitalia (HP:0000022)	1.86458464
80	Optic disc pallor (HP:0000543)	1.85190643
81	Adactyly (HP:0009776)	1.83510532
82	B lymphocytopenia (HP:0010976)	1.81646055
83	Renal Fanconi syndrome (HP:0001994)	1.80875298
84	Methylmalonic aciduria (HP:0012120)	1.80747833
85	Chronic mucocutaneous candidiasis (HP:0002728)	1.79229059
86	Recurrent cutaneous fungal infections (HP:0011370)	1.79229059
87	Polyuria (HP:0000103)	1.78879524
88	Progressive microcephaly (HP:0000253)	1.78557037
89	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.78499349
90	Abnormality of glycine metabolism (HP:0010895)	1.78281437
91	Abnormality of serine family amino acid metabolism (HP:0010894)	1.78281437
92	Cleft eyelid (HP:0000625)	1.78245206
93	Thyroiditis (HP:0100646)	1.77223369
94	Neoplasm of the tracheobronchial system (HP:0100552)	1.77061732
95	Palpitations (HP:0001962)	1.74546814
96	Muscle fiber atrophy (HP:0100295)	1.72786459
97	Macrocytic anemia (HP:0001972)	1.72389922
98	Abnormality of homocysteine metabolism (HP:0010919)	1.71859904
99	Homocystinuria (HP:0002156)	1.71859904
100	Disproportionate short-trunk short stature (HP:0003521)	1.71464300

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	5.14395388
2	ZAK	3.55840860
3	TIE1	3.51653145
4	VRK2	3.45267982
5	MAP4K1	3.33914053
6	MAPKAPK3	3.11223475
7	NUAK1	3.00091159
8	TLK1	2.93523906
9	TAF1	2.34606705
10	TESK2	2.24119476
11	TEC	1.98009787
12	GRK1	1.96040409
13	MAP3K12	1.94588176
14	TAOK3	1.93866906
15	FRK	1.93169704
16	DAPK1	1.90444140
17	SCYL2	1.85915701
18	BMPR2	1.74950848
19	MST4	1.74254735
20	ADRBK2	1.58294565
21	KIT	1.56700547
22	ITK	1.50030254
23	PINK1	1.46621348
24	BCKDK	1.45280120
25	FES	1.43242764
26	CAMKK2	1.42729755
27	IKBKB	1.39028056
28	CSNK1G3	1.38473452
29	MAP3K14	1.35147816
30	PHKG2	1.29615552
31	PHKG1	1.29615552
32	VRK1	1.25054149
33	CSNK1A1L	1.24284321
34	GRK6	1.15902042
35	BTK	1.15394666
36	TRIM28	1.12340290
37	OXSR1	1.11714251
38	DAPK2	1.07129432
39	MAP2K2	1.06823248
40	CSF1R	1.05432681
41	CSNK1G2	1.02787766
42	STK39	1.01503678
43	TNIK	1.00315442
44	CSNK1G1	0.97621598
45	SYK	0.96072210
46	WNK4	0.89447240
47	MAPKAPK5	0.88992995
48	BMPR1B	0.88379344
49	CCNB1	0.86230312
50	ACVR1B	0.84038009
51	LYN	0.83914427
52	JAK3	0.80383540
53	GRK5	0.79187417
54	LCK	0.78112844
55	MAP4K2	0.76925693
56	IKBKE	0.73366175
57	PLK3	0.68151253
58	IGF1R	0.67904965
59	MYLK	0.62070204
60	MKNK2	0.61905062
61	ERBB3	0.60163280
62	PLK2	0.59008211
63	FLT3	0.58580074
64	CAMKK1	0.55705445
65	CDK3	0.54834610
66	PIK3CG	0.54468109
67	RIPK4	0.52565457
68	INSRR	0.51830342
69	HCK	0.51481449
70	PAK3	0.49786622
71	NME1	0.49102284
72	DYRK2	0.48500416
73	EIF2AK2	0.47857647
74	TBK1	0.47207912
75	PTK2B	0.44959151
76	PRKCQ	0.40452216
77	EPHA4	0.40162126
78	MAPK13	0.39155634
79	CDK19	0.38551108
80	PLK4	0.38219462
81	CDK8	0.36857183
82	MATK	0.36193400
83	STK4	0.34382255
84	CHUK	0.31941542
85	ADRBK1	0.31105959
86	MAP3K4	0.31057937
87	DAPK3	0.30951089
88	ERBB2	0.30183958
89	WNK3	0.29800506
90	KDR	0.29717383
91	ABL1	0.29247502
92	TTK	0.25636623
93	TGFBR1	0.25484408
94	ATR	0.23807575
95	CHEK2	0.23607228
96	PRKCH	0.23209324
97	PRKCA	0.23116802
98	PRKCI	0.22684262
99	PIM1	0.22680489
100	CSNK1D	0.21262195

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.75779171
2	Asthma_Homo sapiens_hsa05310	3.42438174
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.17196034
4	Allograft rejection_Homo sapiens_hsa05330	3.16212031
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.96729541
6	Ribosome_Homo sapiens_hsa03010	2.68553849
7	Sulfur metabolism_Homo sapiens_hsa00920	2.58974246
8	Primary immunodeficiency_Homo sapiens_hsa05340	2.45600337
9	Proteasome_Homo sapiens_hsa03050	2.43050300
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.38639701
11	Graft-versus-host disease_Homo sapiens_hsa05332	2.28250896
12	Protein export_Homo sapiens_hsa03060	2.16385762
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.98130231
14	Type I diabetes mellitus_Homo sapiens_hsa04940	1.91267667
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.89514687
16	RNA degradation_Homo sapiens_hsa03018	1.88145711
17	Parkinsons disease_Homo sapiens_hsa05012	1.78696053
18	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.77946368
19	Phototransduction_Homo sapiens_hsa04744	1.69866136
20	RNA polymerase_Homo sapiens_hsa03020	1.69417780
21	Basal transcription factors_Homo sapiens_hsa03022	1.66916544
22	Rheumatoid arthritis_Homo sapiens_hsa05323	1.64510317
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.53913433
24	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.53319921
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.51815550
26	Viral myocarditis_Homo sapiens_hsa05416	1.48475495
27	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.45178059
28	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.44733285
29	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.40510355
30	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.39279336
31	Homologous recombination_Homo sapiens_hsa03440	1.32627047
32	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.30802971
33	Caffeine metabolism_Homo sapiens_hsa00232	1.22990585
34	Alzheimers disease_Homo sapiens_hsa05010	1.18186723
35	Huntingtons disease_Homo sapiens_hsa05016	1.17406018
36	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.15229156
37	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.13405690
38	Selenocompound metabolism_Homo sapiens_hsa00450	1.12388438
39	Tryptophan metabolism_Homo sapiens_hsa00380	1.11270464
40	Nucleotide excision repair_Homo sapiens_hsa03420	1.06826966
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.06126649
42	Pyrimidine metabolism_Homo sapiens_hsa00240	1.04797393
43	Sulfur relay system_Homo sapiens_hsa04122	1.04479312
44	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.04456465
45	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.01065335
46	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.99864154
47	Antigen processing and presentation_Homo sapiens_hsa04612	0.99508564
48	One carbon pool by folate_Homo sapiens_hsa00670	0.99290788
49	Cardiac muscle contraction_Homo sapiens_hsa04260	0.99211226
50	Ether lipid metabolism_Homo sapiens_hsa00565	0.98762688
51	Fatty acid elongation_Homo sapiens_hsa00062	0.98163783
52	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.96486157
53	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.88437460
54	RNA transport_Homo sapiens_hsa03013	0.87384205
55	Fanconi anemia pathway_Homo sapiens_hsa03460	0.86983904
56	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.84619960
57	Base excision repair_Homo sapiens_hsa03410	0.79267632
58	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.78447996
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.72562791
60	Regulation of autophagy_Homo sapiens_hsa04140	0.72390841
61	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.71286539
62	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.69782767
63	Collecting duct acid secretion_Homo sapiens_hsa04966	0.68884269
64	Purine metabolism_Homo sapiens_hsa00230	0.67938809
65	Mismatch repair_Homo sapiens_hsa03430	0.67881574
66	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.67231143
67	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.65471123
68	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.64569556
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.62561451
70	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.57250855
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.54612416
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54181768
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49844367
74	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.49728973
75	Peroxisome_Homo sapiens_hsa04146	0.49234845
76	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.46406783
77	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.46173495
78	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.44970403
79	Metabolic pathways_Homo sapiens_hsa01100	0.44370544
80	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.43655112
81	Measles_Homo sapiens_hsa05162	0.43321208
82	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.41536077
83	Leishmaniasis_Homo sapiens_hsa05140	0.38451675
84	Propanoate metabolism_Homo sapiens_hsa00640	0.36439900
85	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.35491249
86	Herpes simplex infection_Homo sapiens_hsa05168	0.35176040
87	Folate biosynthesis_Homo sapiens_hsa00790	0.34011929
88	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.32160519
89	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.29336980
90	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.26869564
91	ABC transporters_Homo sapiens_hsa02010	0.26855123
92	p53 signaling pathway_Homo sapiens_hsa04115	0.23647950
93	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.23237077
94	Retinol metabolism_Homo sapiens_hsa00830	0.21545997
95	Pyruvate metabolism_Homo sapiens_hsa00620	0.21147452
96	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.20796309
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.17228411
98	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.17176254
99	Steroid biosynthesis_Homo sapiens_hsa00100	0.16780322
100	Spliceosome_Homo sapiens_hsa03040	0.15987370

RPL23P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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