RPL23P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1relaxation of smooth muscle (GO:0044557)8.62593842
2rRNA catabolic process (GO:0016075)8.18318039
3sphingosine metabolic process (GO:0006670)7.71253907
4cGMP-mediated signaling (GO:0019934)7.30293598
5negative regulation of homotypic cell-cell adhesion (GO:0034111)7.21250097
6regulation of mitochondrial translation (GO:0070129)7.08151333
7diol metabolic process (GO:0034311)6.96548298
8sphingoid metabolic process (GO:0046519)6.29189656
9negative regulation of leukocyte chemotaxis (GO:0002689)6.26389652
10positive regulation of histone deacetylation (GO:0031065)5.90847323
11DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla5.90551242
12ceramide catabolic process (GO:0046514)5.86663709
13motile cilium assembly (GO:0044458)5.66649730
14DNA damage response, signal transduction resulting in transcription (GO:0042772)5.48151981
15negative regulation by host of viral transcription (GO:0043922)5.42277197
16regulation of platelet aggregation (GO:0090330)5.31153842
17positive regulation by host of viral transcription (GO:0043923)5.26953913
18white fat cell differentiation (GO:0050872)5.26487224
19water-soluble vitamin biosynthetic process (GO:0042364)5.19503580
20synaptic transmission, cholinergic (GO:0007271)4.88480766
21negative regulation of telomere maintenance (GO:0032205)4.78197355
22negative regulation of histone acetylation (GO:0035067)4.77681965
23negative regulation of smooth muscle contraction (GO:0045986)4.70005836
24negative regulation of platelet activation (GO:0010544)4.65915536
25pathway-restricted SMAD protein phosphorylation (GO:0060389)4.56492075
26ncRNA catabolic process (GO:0034661)4.49574060
27kynurenine metabolic process (GO:0070189)4.34083602
28negative regulation of telomerase activity (GO:0051974)4.30541102
29positive regulation of protein deacetylation (GO:0090312)4.29499664
30negative regulation of cell cycle arrest (GO:0071157)4.19972667
31regulation of histone deacetylation (GO:0031063)4.19871513
32establishment of protein localization to mitochondrial membrane (GO:0090151)4.12634405
33negative regulation of T cell differentiation in thymus (GO:0033085)4.07109104
34regulation of respiratory system process (GO:0044065)4.04134578
35membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.98975631
36negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.92725447
37adaptation of signaling pathway (GO:0023058)3.90601062
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.88928327
39positive regulation of T cell apoptotic process (GO:0070234)3.88705451
40positive regulation of interleukin-17 production (GO:0032740)3.87854891
41N-glycan processing (GO:0006491)3.81843840
42membrane repolarization during action potential (GO:0086011)3.80090374
43mesenchymal cell differentiation (GO:0048762)3.76663645
44regulation of skeletal muscle contraction (GO:0014819)3.72837683
45negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.72715245
46protein localization to cilium (GO:0061512)3.72314319
47negative regulation of peptidyl-lysine acetylation (GO:2000757)3.70879679
48RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.70579619
49regulation of mesoderm development (GO:2000380)3.67657367
50regulation of telomere maintenance via telomerase (GO:0032210)3.62342274
51cellular response to dexamethasone stimulus (GO:0071549)3.59780343
52indole-containing compound catabolic process (GO:0042436)3.58902596
53indolalkylamine catabolic process (GO:0046218)3.58902596
54tryptophan catabolic process (GO:0006569)3.58902596
55cell differentiation involved in kidney development (GO:0061005)3.54650719
56response to pH (GO:0009268)3.47837833
57negative regulation of protein acetylation (GO:1901984)3.44342225
58iron-sulfur cluster assembly (GO:0016226)3.44330781
59metallo-sulfur cluster assembly (GO:0031163)3.44330781
60relaxation of muscle (GO:0090075)3.37894567
61indolalkylamine metabolic process (GO:0006586)3.36674146
62adipose tissue development (GO:0060612)3.35732588
63regulation of hippo signaling (GO:0035330)3.33760881
64response to dexamethasone (GO:0071548)3.32201648
65peptidyl-histidine modification (GO:0018202)3.29583103
66negative regulation of execution phase of apoptosis (GO:1900118)3.24647697
67fucose catabolic process (GO:0019317)3.24358133
68L-fucose metabolic process (GO:0042354)3.24358133
69L-fucose catabolic process (GO:0042355)3.24358133
70negative regulation of muscle contraction (GO:0045932)3.22675042
71replicative senescence (GO:0090399)3.12613892
72sphingolipid catabolic process (GO:0030149)3.10048729
73positive regulation of lymphocyte apoptotic process (GO:0070230)3.05180652
74regulation of interleukin-8 secretion (GO:2000482)3.04303689
75neuromuscular synaptic transmission (GO:0007274)3.02949878
76regulation of homotypic cell-cell adhesion (GO:0034110)3.02539799
77L-ascorbic acid metabolic process (GO:0019852)3.00164569
78snRNA transcription (GO:0009301)2.96397465
79positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.95305973
80histone H3-K36 demethylation (GO:0070544)2.95134176
81activin receptor signaling pathway (GO:0032924)2.93461405
82tryptophan metabolic process (GO:0006568)2.92615909
83regulation of respiratory gaseous exchange (GO:0043576)2.92003932
84regulation of telomerase activity (GO:0051972)2.90686663
85auditory receptor cell stereocilium organization (GO:0060088)2.90501896
86mitochondrial genome maintenance (GO:0000002)2.88663318
87regulation of protein deacetylation (GO:0090311)2.86647505
88oxidative demethylation (GO:0070989)2.83113381
89positive regulation of heat generation (GO:0031652)2.82529887
90polyol biosynthetic process (GO:0046173)2.81733502
91regulation of thymocyte apoptotic process (GO:0070243)2.79381646
92modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.77332575
93negative regulation of transcription regulatory region DNA binding (GO:2000678)2.74471631
94membrane lipid catabolic process (GO:0046466)2.73916641
95regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.72133847
96indole-containing compound metabolic process (GO:0042430)2.71045960
97negative regulation of macroautophagy (GO:0016242)2.68794195
98mesenchymal cell differentiation involved in renal system development (GO:2001012)11.4442826
99mesenchymal cell differentiation involved in kidney development (GO:0072161)11.4442826
100behavioral response to nicotine (GO:0035095)10.1252474

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse5.78851608
2EZH2_22144423_ChIP-Seq_EOC_Human4.41011265
3ZNF274_21170338_ChIP-Seq_K562_Hela3.58794691
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.55554164
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.42904194
6VDR_22108803_ChIP-Seq_LS180_Human3.37124718
7IGF1R_20145208_ChIP-Seq_DFB_Human2.82954578
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.63786251
9GBX2_23144817_ChIP-Seq_PC3_Human2.45430602
10IRF1_19129219_ChIP-ChIP_H3396_Human2.34937513
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.33650381
12EWS_26573619_Chip-Seq_HEK293_Human2.19452715
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14232400
14EZH2_27304074_Chip-Seq_ESCs_Mouse1.98662254
15EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.94764168
16JARID2_20064375_ChIP-Seq_MESCs_Mouse1.94638798
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.93372719
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89329837
19REST_21632747_ChIP-Seq_MESCs_Mouse1.86869551
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81464921
21ETV2_25802403_ChIP-Seq_MESCs_Mouse1.72790613
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68080740
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65716280
24TAF15_26573619_Chip-Seq_HEK293_Human1.63730820
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.60983857
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.56677962
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54748195
28EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.54697160
29NCOR_22424771_ChIP-Seq_293T_Human1.54385982
30NR3C1_21868756_ChIP-Seq_MCF10A_Human1.53789281
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51779058
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50883270
33TP53_22573176_ChIP-Seq_HFKS_Human1.50068280
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.47890534
35AR_25329375_ChIP-Seq_VCAP_Human1.47230564
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.44213502
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42815703
38P300_19829295_ChIP-Seq_ESCs_Human1.35615363
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.34790036
40TCF4_23295773_ChIP-Seq_U87_Human1.33217960
41HOXB7_26014856_ChIP-Seq_BT474_Human1.31345391
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.31147770
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.28945579
44STAT3_23295773_ChIP-Seq_U87_Human1.28041807
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24772398
46RUNX2_22187159_ChIP-Seq_PCA_Human1.24442233
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.23768973
48SMAD4_21799915_ChIP-Seq_A2780_Human1.23480023
49ER_23166858_ChIP-Seq_MCF-7_Human1.22673059
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21559566
51CBP_20019798_ChIP-Seq_JUKART_Human1.21559566
52BCAT_22108803_ChIP-Seq_LS180_Human1.18353498
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.17905814
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.17905814
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.15389594
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13016017
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12701437
58VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11594749
59MYC_19829295_ChIP-Seq_ESCs_Human1.10986454
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10546932
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10261003
62FUS_26573619_Chip-Seq_HEK293_Human1.08749066
63SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07959412
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.06121994
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.05766402
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.04815944
67AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04168364
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04149746
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.02419035
70CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.01462693
71AR_20517297_ChIP-Seq_VCAP_Human1.01377821
72CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00661153
73AHR_22903824_ChIP-Seq_MCF-7_Human1.00210833
74SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99282067
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98944865
76TCF4_22108803_ChIP-Seq_LS180_Human0.97844772
77OCT4_20526341_ChIP-Seq_ESCs_Human0.96037767
78FOXA1_25329375_ChIP-Seq_VCAP_Human0.95648539
79FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95648539
80NFYB_21822215_ChIP-Seq_K562_Human0.94946047
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94692601
82PRDM14_20953172_ChIP-Seq_ESCs_Human0.93730345
83SMAD4_21741376_ChIP-Seq_EPCs_Human0.93351873
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93290897
85DROSHA_22980978_ChIP-Seq_HELA_Human0.93257702
86ERG_21242973_ChIP-ChIP_JURKAT_Human0.92488110
87ERA_21632823_ChIP-Seq_H3396_Human0.91318244
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90388852
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.89596542
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89417825
91RNF2_27304074_Chip-Seq_NSC_Mouse0.89123824
92RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89048652
93SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88829534
94NANOG_20526341_ChIP-Seq_ESCs_Human0.88789258
95ELF1_20517297_ChIP-Seq_JURKAT_Human0.88709833
96PHF8_20622853_ChIP-Seq_HELA_Human0.88597673
97SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.87971450
98KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.86576855
99SOX2_19829295_ChIP-Seq_ESCs_Human0.86552750
100NANOG_19829295_ChIP-Seq_ESCs_Human0.86552750

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation8.23670255
2MP0004084_abnormal_cardiac_muscle3.88133135
3MP0010386_abnormal_urinary_bladder3.72562163
4MP0003183_abnormal_peptide_metabolism3.67897966
5MP0004145_abnormal_muscle_electrophysio3.53550094
6MP0001873_stomach_inflammation3.04793473
7MP0003950_abnormal_plasma_membrane2.78554109
8MP0003195_calcinosis2.72479137
9MP0003879_abnormal_hair_cell2.61192490
10MP0005360_urolithiasis2.35057912
11MP0000049_abnormal_middle_ear2.34906136
12MP0008872_abnormal_physiological_respon2.24662885
13MP0001661_extended_life_span2.18409994
14MP0000427_abnormal_hair_cycle2.16782449
15MP0002102_abnormal_ear_morphology2.10295995
16MP0001664_abnormal_digestion2.09037618
17MP0001485_abnormal_pinna_reflex2.08472439
18MP0004036_abnormal_muscle_relaxation1.98221658
19MP0009384_cardiac_valve_regurgitation1.92497999
20MP0003646_muscle_fatigue1.88490731
21MP0003693_abnormal_embryo_hatching1.79272134
22MP0005551_abnormal_eye_electrophysiolog1.69372767
23MP0004142_abnormal_muscle_tone1.69082598
24MP0005220_abnormal_exocrine_pancreas1.58571403
25MP0001963_abnormal_hearing_physiology1.57836526
26MP0000631_abnormal_neuroendocrine_gland1.51685606
27MP0003137_abnormal_impulse_conducting1.50728801
28MP0002736_abnormal_nociception_after1.50607348
29MP0004742_abnormal_vestibular_system1.47358027
30MP0001968_abnormal_touch/_nociception1.41553332
31MP0004885_abnormal_endolymph1.40249755
32MP0009745_abnormal_behavioral_response1.36110759
33MP0002938_white_spotting1.32608354
34MP0000470_abnormal_stomach_morphology1.31641043
35MP0002234_abnormal_pharynx_morphology1.31278648
36MP0008058_abnormal_DNA_repair1.29036269
37MP0006292_abnormal_olfactory_placode1.27127610
38MP0000538_abnormal_urinary_bladder1.26265025
39MP0000749_muscle_degeneration1.25393091
40MP0008875_abnormal_xenobiotic_pharmacok1.23968852
41MP0000230_abnormal_systemic_arterial1.23896260
42MP0000685_abnormal_immune_system1.19941967
43MP0005646_abnormal_pituitary_gland1.19592465
44MP0001501_abnormal_sleep_pattern1.19324197
45MP0002735_abnormal_chemical_nociception1.19114936
46MP0003786_premature_aging1.18213225
47MP0001986_abnormal_taste_sensitivity1.13061614
48MP0004215_abnormal_myocardial_fiber1.09314431
49MP0009046_muscle_twitch1.08994446
50MP0005377_hearing/vestibular/ear_phenot1.05702222
51MP0003878_abnormal_ear_physiology1.05702222
52MP0003045_fibrosis1.03656793
53MP0002638_abnormal_pupillary_reflex1.02955185
54MP0002138_abnormal_hepatobiliary_system1.01567376
55MP0000750_abnormal_muscle_regeneration0.96232646
56MP0003119_abnormal_digestive_system0.95673140
57MP0005645_abnormal_hypothalamus_physiol0.94637572
58MP0005253_abnormal_eye_physiology0.94431400
59MP0002396_abnormal_hematopoietic_system0.94060902
60MP0002733_abnormal_thermal_nociception0.88544905
61MP0001440_abnormal_grooming_behavior0.86336061
62MP0005620_abnormal_muscle_contractility0.85980067
63MP0004043_abnormal_pH_regulation0.85098004
64MP0002064_seizures0.84366694
65MP0002572_abnormal_emotion/affect_behav0.83733319
66MP0005595_abnormal_vascular_smooth0.83599330
67MP0000733_abnormal_muscle_development0.81422293
68MP0001970_abnormal_pain_threshold0.79721905
69MP0002272_abnormal_nervous_system0.79360728
70MP0003718_maternal_effect0.78589607
71MP0002160_abnormal_reproductive_system0.78569268
72MP0006276_abnormal_autonomic_nervous0.77892829
73MP0003806_abnormal_nucleotide_metabolis0.77487560
74MP0005195_abnormal_posterior_eye0.76490929
75MP0000383_abnormal_hair_follicle0.76062266
76MP0000026_abnormal_inner_ear0.75041526
77MP0002163_abnormal_gland_morphology0.74330934
78MP0002295_abnormal_pulmonary_circulatio0.74043003
79MP0001879_abnormal_lymphatic_vessel0.73442289
80MP0005085_abnormal_gallbladder_physiolo0.73096433
81MP0005167_abnormal_blood-brain_barrier0.73076483
82MP0001663_abnormal_digestive_system0.72749486
83MP0005381_digestive/alimentary_phenotyp0.71606484
84MP0003635_abnormal_synaptic_transmissio0.70179960
85MP0002095_abnormal_skin_pigmentation0.67996996
86MP0002972_abnormal_cardiac_muscle0.67179092
87MP0008877_abnormal_DNA_methylation0.67119716
88MP0002693_abnormal_pancreas_physiology0.66360079
89MP0001486_abnormal_startle_reflex0.65611611
90MP0003698_abnormal_male_reproductive0.64747089
91MP0002752_abnormal_somatic_nervous0.64066833
92MP0005389_reproductive_system_phenotype0.63477518
93MP0004019_abnormal_vitamin_homeostasis0.62671678
94MP0002269_muscular_atrophy0.62451088
95MP0004085_abnormal_heartbeat0.60070923
96MP0001324_abnormal_eye_pigmentation0.58794384
97MP0002184_abnormal_innervation0.56401473
98MP0003136_yellow_coat_color0.54243836
99MP0005410_abnormal_fertilization0.54088327
100MP0003638_abnormal_response/metabolism_0.52144082

Predicted human phenotypes

RankGene SetZ-score
1Fibular aplasia (HP:0002990)8.79520495
2Fibular hypoplasia (HP:0003038)7.80109466
3Partial agenesis of the corpus callosum (HP:0001338)6.64632884
4Broad ribs (HP:0000885)6.19838775
5Bilateral microphthalmos (HP:0007633)6.18432118
6Unilateral renal agenesis (HP:0000122)6.15228149
7Hypoplasia of the fovea (HP:0007750)6.14312654
8Aplasia/Hypoplasia of the fovea (HP:0008060)6.14312654
9Delayed closure of the anterior fontanelle (HP:0001476)5.66139078
10Natal tooth (HP:0000695)5.45459282
11Aplasia/Hypoplasia of the fibula (HP:0006492)5.41597717
12Abnormality of the lumbar spine (HP:0100712)5.31939890
13Abnormality of the fovea (HP:0000493)4.92367865
14Thoracic kyphosis (HP:0002942)4.91154094
15Aplasia/Hypoplasia involving the sinuses (HP:0009120)4.61616123
16Fused cervical vertebrae (HP:0002949)4.28292531
17Tracheomalacia (HP:0002779)4.08647891
18Aplasia/Hypoplasia of the macula (HP:0008059)3.91423977
19Decreased circulating renin level (HP:0003351)3.90608895
20Anal stenosis (HP:0002025)3.76171071
21Aortic aneurysm (HP:0004942)3.75561948
22Aplasia/Hypoplasia affecting the retina (HP:0008061)3.63228657
23Rough bone trabeculation (HP:0100670)3.52231287
24Abnormality of the thoracic spine (HP:0100711)3.50417001
25Bifid uvula (HP:0000193)3.29161675
26Mixed hearing impairment (HP:0000410)3.05585832
27Thickened calvaria (HP:0002684)3.03288889
28Wide intermamillary distance (HP:0006610)2.77568688
29Abnormality of the fibula (HP:0002991)2.75695965
30Nasal speech (HP:0001611)2.73558952
31Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.73345138
32Abnormal trabecular bone morphology (HP:0100671)2.72800581
33Flared iliac wings (HP:0002869)2.69058301
34Flat capital femoral epiphysis (HP:0003370)2.67745393
35Concave nail (HP:0001598)2.65420948
36Advanced eruption of teeth (HP:0006288)2.54941892
37Colon cancer (HP:0003003)2.47521382
38Delayed cranial suture closure (HP:0000270)2.43371312
39Metabolic alkalosis (HP:0200114)2.33600124
40Overfolded helix (HP:0000396)2.32152722
41Abnormality of glycolipid metabolism (HP:0010969)2.31568808
42Abnormality of liposaccharide metabolism (HP:0010968)2.31568808
43Abnormality of glycosphingolipid metabolism (HP:0004343)2.31568808
44Brittle hair (HP:0002299)2.30659821
45Craniofacial hyperostosis (HP:0004493)2.29362010
46Enlarged kidneys (HP:0000105)2.28315351
47Tubulointerstitial nephritis (HP:0001970)2.25735347
48Pancreatic cysts (HP:0001737)2.23948158
49Abnormality of the renal cortex (HP:0011035)2.22736222
50Capillary hemangiomas (HP:0005306)2.22620980
51Attenuation of retinal blood vessels (HP:0007843)2.20368022
52Nephronophthisis (HP:0000090)2.19966601
53Abnormality of renin-angiotensin system (HP:0000847)2.15766038
54Decreased central vision (HP:0007663)2.15699422
55Congenital stationary night blindness (HP:0007642)2.11742971
56Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09761205
57Cystic liver disease (HP:0006706)2.09018930
58Abnormally folded helix (HP:0008544)2.06309724
59Type II lissencephaly (HP:0007260)2.04403440
60Multifactorial inheritance (HP:0001426)2.02414117
61Webbed neck (HP:0000465)2.01888214
62Patent foramen ovale (HP:0001655)2.01542645
63Bony spicule pigmentary retinopathy (HP:0007737)2.00994956
64Asymmetry of the thorax (HP:0001555)10.0661559
65Neoplasm of the adrenal cortex (HP:0100641)1.98946153
66Chronic sinusitis (HP:0011109)1.98037964
67Decreased activity of mitochondrial respiratory chain (HP:0008972)1.97123710
68Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.97123710
69Gastroesophageal reflux (HP:0002020)1.94798641
70Vertebral fusion (HP:0002948)1.94028079
71Pancreatic fibrosis (HP:0100732)1.91664709
72Renal cortical cysts (HP:0000803)1.90926285
73Abnormality of the wing of the ilium (HP:0011867)1.90502458
74True hermaphroditism (HP:0010459)1.88614612
75Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86738797
76Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.82472121
77Molar tooth sign on MRI (HP:0002419)1.81563753
78Abnormality of midbrain morphology (HP:0002418)1.81563753
79Oligohydramnios (HP:0001562)1.79576282
80Tubular atrophy (HP:0000092)1.79068922
81Microtia (HP:0008551)1.77200972
82Neoplasm of the heart (HP:0100544)1.73931608
83Cerebral palsy (HP:0100021)1.72449846
84Abnormality of the renal medulla (HP:0100957)1.72339691
85Abolished electroretinogram (ERG) (HP:0000550)1.70246877
86Broad distal phalanx of finger (HP:0009836)1.68772640
87Hyperglycinuria (HP:0003108)1.68647915
88Congenital, generalized hypertrichosis (HP:0004540)1.63771966
89Cranial hyperostosis (HP:0004437)1.61107492
90Chronic hepatic failure (HP:0100626)1.59254254
91Medial flaring of the eyebrow (HP:0010747)1.58616506
92Anal atresia (HP:0002023)1.58349597
93Joint contractures involving the joints of the feet (HP:0100492)1.55795730
94Flexion contracture of toe (HP:0005830)1.55795730
95Focal seizures (HP:0007359)1.55294964
96Polydipsia (HP:0001959)1.51294209
97Abnormal drinking behavior (HP:0030082)1.51294209
98Hypokalemia (HP:0002900)1.50781668
99Narrow forehead (HP:0000341)1.49203973
100Hemiparesis (HP:0001269)1.48044103

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.66541158
2PRKG25.27092433
3TAF15.12918409
4SMG14.31449878
5NUAK13.77537136
6HIPK23.37083986
7ICK3.19360444
8WNK42.91802695
9FRK2.83154526
10ZAK2.79953549
11MELK2.56845499
12MAPKAPK52.10747756
13STK391.80270934
14STK111.79112689
15GRK11.64219276
16LIMK11.58933541
17VRK11.58666768
18OXSR11.57796093
19ADRBK21.52450723
20GRK51.43963473
21DYRK21.42747034
22INSRR1.35037951
23PINK11.29707124
24PRKAA21.29375088
25CDK191.26880566
26PRKCG1.24954069
27PRKAA11.05082591
28MAP4K21.03199788
29CSNK1G31.02041746
30DAPK10.98059979
31CSNK1A1L0.93886491
32PKN10.93506561
33ACVR1B0.92788418
34CSNK1G20.89754500
35TAOK30.87610432
36NTRK30.87499170
37PIK3CA0.86234792
38BMPR1B0.83704054
39TLK10.82067931
40DAPK20.81185118
41MAP2K60.81113130
42CSNK1G10.78395869
43PLK30.77241386
44EIF2AK20.74647948
45PRKG10.72873315
46WNK30.69210368
47CASK0.67432483
48CHEK20.65781507
49MAPKAPK30.65034981
50IKBKB0.63485873
51CAMKK20.61758573
52MAP3K90.59168727
53PAK20.58934151
54ADRBK10.56329309
55WNK10.56221163
56MAPK130.54330504
57PAK10.53856009
58TIE10.53578029
59DAPK30.48274294
60PBK0.48218136
61PRKCE0.43081478
62CSNK1D0.41730479
63STK38L0.41335954
64PRKCA0.41072398
65CDK90.40901849
66EPHA40.40862370
67CSNK1A10.40246576
68MAP2K10.39469296
69AURKA0.36711445
70SYK0.36100757
71CAMK2A0.35447726
72PRKD30.35155625
73TYRO30.33439044
74MAP3K40.30985245
75NEK20.29914077
76RPS6KA60.29728218
77MKNK20.29541387
78DYRK1A0.28661320
79ATR0.27591328
80PRKACA0.27369516
81NME10.26712848
82ITK0.26331986
83PLK10.25227628
84CDC70.25050088
85IGF1R0.24756437
86PHKG10.23753661
87PHKG20.23753661
88BCKDK0.23607581
89STK160.21815122
90OBSCN0.21270205
91CAMK10.20245465
92TGFBR10.20182772
93PRKCB0.19821153
94CDK70.19208819
95TXK0.18113196
96MARK10.17834153
97EIF2AK30.17532152
98CSNK2A10.17220762
99CAMK40.16895923
100CAMKK10.16288310

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.67623284
2Nicotine addiction_Homo sapiens_hsa050332.74794507
3Circadian entrainment_Homo sapiens_hsa047132.68698306
4Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.37985126
5Sphingolipid metabolism_Homo sapiens_hsa006002.17546299
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.12754973
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.09319251
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.07126255
9Morphine addiction_Homo sapiens_hsa050322.04912116
10GABAergic synapse_Homo sapiens_hsa047272.04294919
11Cyanoamino acid metabolism_Homo sapiens_hsa004602.03215886
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.94829160
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.93221677
14Salivary secretion_Homo sapiens_hsa049701.85531889
15Linoleic acid metabolism_Homo sapiens_hsa005911.74237258
16Fat digestion and absorption_Homo sapiens_hsa049751.73390445
17ABC transporters_Homo sapiens_hsa020101.71477159
18RNA degradation_Homo sapiens_hsa030181.71316667
19Tryptophan metabolism_Homo sapiens_hsa003801.70856678
20Olfactory transduction_Homo sapiens_hsa047401.67075125
21Glutamatergic synapse_Homo sapiens_hsa047241.63928754
22Glycerolipid metabolism_Homo sapiens_hsa005611.60717199
23Cholinergic synapse_Homo sapiens_hsa047251.59542322
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58590204
25Phototransduction_Homo sapiens_hsa047441.51800604
26Protein export_Homo sapiens_hsa030601.47503071
27Long-term depression_Homo sapiens_hsa047301.45537318
28Nitrogen metabolism_Homo sapiens_hsa009101.43388844
29Ovarian steroidogenesis_Homo sapiens_hsa049131.37212634
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32169995
31Butanoate metabolism_Homo sapiens_hsa006501.30881262
32Retinol metabolism_Homo sapiens_hsa008301.30121103
33Ribosome_Homo sapiens_hsa030101.29154527
34Oxidative phosphorylation_Homo sapiens_hsa001901.27871115
35Caffeine metabolism_Homo sapiens_hsa002321.25307975
36Serotonergic synapse_Homo sapiens_hsa047261.24688991
37Insulin secretion_Homo sapiens_hsa049111.22411225
38Ether lipid metabolism_Homo sapiens_hsa005651.22228875
39Vascular smooth muscle contraction_Homo sapiens_hsa042701.19297026
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19296236
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15887042
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.15198006
43Primary immunodeficiency_Homo sapiens_hsa053401.13805198
44Chemical carcinogenesis_Homo sapiens_hsa052041.11625412
45Selenocompound metabolism_Homo sapiens_hsa004501.09129949
46Cardiac muscle contraction_Homo sapiens_hsa042601.07049986
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.06075849
48Parkinsons disease_Homo sapiens_hsa050121.05764520
49Basal transcription factors_Homo sapiens_hsa030221.02801851
50Primary bile acid biosynthesis_Homo sapiens_hsa001201.01543828
51Calcium signaling pathway_Homo sapiens_hsa040200.94994613
52Homologous recombination_Homo sapiens_hsa034400.93252629
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92337842
54One carbon pool by folate_Homo sapiens_hsa006700.89706296
55RNA polymerase_Homo sapiens_hsa030200.89307080
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86960280
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.85170436
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83303563
59Huntingtons disease_Homo sapiens_hsa050160.82382567
60African trypanosomiasis_Homo sapiens_hsa051430.80613757
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80270808
62Histidine metabolism_Homo sapiens_hsa003400.79507157
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78434800
64Gastric acid secretion_Homo sapiens_hsa049710.75976868
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73548156
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72496381
67Fatty acid degradation_Homo sapiens_hsa000710.72242469
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70655279
69Asthma_Homo sapiens_hsa053100.68858197
70Taste transduction_Homo sapiens_hsa047420.64504975
71Alzheimers disease_Homo sapiens_hsa050100.64155695
72Mineral absorption_Homo sapiens_hsa049780.64124907
73Vitamin digestion and absorption_Homo sapiens_hsa049770.63648780
74Sulfur relay system_Homo sapiens_hsa041220.63009985
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59844696
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59038462
77Pyrimidine metabolism_Homo sapiens_hsa002400.57551409
78Dopaminergic synapse_Homo sapiens_hsa047280.56581940
79Bile secretion_Homo sapiens_hsa049760.56411936
80Arachidonic acid metabolism_Homo sapiens_hsa005900.56109266
81Metabolic pathways_Homo sapiens_hsa011000.55144016
82Propanoate metabolism_Homo sapiens_hsa006400.52124745
83Amphetamine addiction_Homo sapiens_hsa050310.50835114
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47534843
85Arginine and proline metabolism_Homo sapiens_hsa003300.46089149
86cAMP signaling pathway_Homo sapiens_hsa040240.44834420
87Renin secretion_Homo sapiens_hsa049240.43391973
88N-Glycan biosynthesis_Homo sapiens_hsa005100.42479188
89RNA transport_Homo sapiens_hsa030130.40239657
90Purine metabolism_Homo sapiens_hsa002300.39063363
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.38127934
92Basal cell carcinoma_Homo sapiens_hsa052170.38034961
93Dilated cardiomyopathy_Homo sapiens_hsa054140.37744733
94Sulfur metabolism_Homo sapiens_hsa009200.36968305
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36917799
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35009326
97TGF-beta signaling pathway_Homo sapiens_hsa043500.34449523
98Gap junction_Homo sapiens_hsa045400.33102651
99beta-Alanine metabolism_Homo sapiens_hsa004100.32532468
100Malaria_Homo sapiens_hsa051440.32194879

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