RPL23P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cytosolic calcium ion concentration (GO:0051481)9.57793778
2negative regulation of cAMP-mediated signaling (GO:0043951)8.36295279
3regulation of translational termination (GO:0006449)8.02917598
4opioid receptor signaling pathway (GO:0038003)7.51087879
5behavioral response to ethanol (GO:0048149)6.76502767
6ether lipid metabolic process (GO:0046485)6.26457813
7piRNA metabolic process (GO:0034587)6.25555406
8adult feeding behavior (GO:0008343)6.08052026
9negative regulation of calcium ion-dependent exocytosis (GO:0045955)5.96222266
10regulation of acrosome reaction (GO:0060046)5.73370526
11mRNA cleavage (GO:0006379)5.60009241
12N-terminal protein amino acid acetylation (GO:0006474)5.10419882
13detection of chemical stimulus involved in sensory perception of smell (GO:0050911)5.04846616
14sphingosine metabolic process (GO:0006670)4.99183259
15ncRNA catabolic process (GO:0034661)4.85767182
16negative regulation of nitric oxide biosynthetic process (GO:0045019)4.85480491
17response to pheromone (GO:0019236)4.67575980
18diol metabolic process (GO:0034311)4.61636936
19adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.54030567
20positive regulation of cAMP-mediated signaling (GO:0043950)4.52289300
21sphingoid metabolic process (GO:0046519)4.46718750
22DNA replication-dependent nucleosome assembly (GO:0006335)4.45033484
23DNA replication-dependent nucleosome organization (GO:0034723)4.45033484
24glycerol ether metabolic process (GO:0006662)4.32734873
25cytokinetic process (GO:0032506)4.31328527
26RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)4.26642973
27thrombin receptor signaling pathway (GO:0070493)4.22097608
28apoptotic DNA fragmentation (GO:0006309)4.06687031
29notochord development (GO:0030903)4.04783496
30ether metabolic process (GO:0018904)3.98609883
31regulation of protein glycosylation (GO:0060049)3.96436226
32regulation of translational elongation (GO:0006448)3.88443407
33positive regulation of muscle cell apoptotic process (GO:0010661)3.82825474
34DNA deamination (GO:0045006)3.75508876
35sensory perception of smell (GO:0007608)3.66808317
36positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.64983307
37folic acid-containing compound biosynthetic process (GO:0009396)3.55892749
38regulation of rhodopsin mediated signaling pathway (GO:0022400)3.54005919
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.51532189
40replicative senescence (GO:0090399)3.39951727
41negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.34598905
42pseudouridine synthesis (GO:0001522)3.31781810
43cell morphogenesis involved in neuron differentiation (GO:0048667)3.27742568
44phosphatidylserine acyl-chain remodeling (GO:0036150)3.26624499
45regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.25243929
46rhodopsin mediated signaling pathway (GO:0016056)3.23973374
47glomerular visceral epithelial cell development (GO:0072015)3.20225959
48negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.15720407
49detection of chemical stimulus involved in sensory perception (GO:0050907)3.14839366
50sister chromatid cohesion (GO:0007062)3.12294297
51preassembly of GPI anchor in ER membrane (GO:0016254)3.09932084
52negative regulation of DNA-dependent DNA replication (GO:2000104)3.08198159
53negative regulation of interleukin-8 production (GO:0032717)3.00184929
54maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.96611728
55positive regulation of fatty acid transport (GO:2000193)2.96570076
56N-terminal protein amino acid modification (GO:0031365)2.91202883
57positive regulation of immune response to tumor cell (GO:0002839)2.89530566
58regulation of immune response to tumor cell (GO:0002837)2.89530566
59regulation of response to tumor cell (GO:0002834)2.89530566
60positive regulation of response to tumor cell (GO:0002836)2.89530566
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.89378272
62ribonucleoprotein complex disassembly (GO:0032988)2.88611131
63positive regulation of icosanoid secretion (GO:0032305)2.88168454
64regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.88052968
65replication fork processing (GO:0031297)2.85772812
66regulation of nuclear cell cycle DNA replication (GO:0033262)2.85755056
67cellular response to alkaloid (GO:0071312)2.85351301
68cellular response to ammonium ion (GO:0071242)2.85126428
69G-protein coupled receptor internalization (GO:0002031)2.84387686
70DNA synthesis involved in DNA repair (GO:0000731)2.83680233
71cornea development in camera-type eye (GO:0061303)2.83208174
72negative regulation of glycoprotein biosynthetic process (GO:0010561)2.82512991
73sulfate transport (GO:0008272)2.81898143
74rRNA modification (GO:0000154)2.81852433
75regulation of smooth muscle cell apoptotic process (GO:0034391)2.81306173
76phosphatidylinositol acyl-chain remodeling (GO:0036149)2.80599004
77coenzyme catabolic process (GO:0009109)2.80247723
78quinone biosynthetic process (GO:1901663)2.79675402
79viral mRNA export from host cell nucleus (GO:0046784)2.79208824
80regulation of cAMP-mediated signaling (GO:0043949)2.76588710
81regulation of double-strand break repair via homologous recombination (GO:0010569)2.76588132
82pteridine-containing compound biosynthetic process (GO:0042559)2.76091403
83glomerular epithelial cell development (GO:0072310)2.74104510
84rRNA methylation (GO:0031167)2.67748541
85rRNA catabolic process (GO:0016075)2.66436912
86regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.62726859
87gene silencing by RNA (GO:0031047)2.61091647
88resolution of meiotic recombination intermediates (GO:0000712)2.58093045
89regulation of female receptivity (GO:0045924)2.55487815
90phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.53445562
91regulation of glutamate receptor signaling pathway (GO:1900449)2.51516046
92recombinational repair (GO:0000725)2.51161105
93vitamin catabolic process (GO:0009111)2.51023294
94fat-soluble vitamin catabolic process (GO:0042363)2.51023294
95double-strand break repair via homologous recombination (GO:0000724)2.50848841
96positive regulation of Rho protein signal transduction (GO:0035025)2.50121691
97glyoxylate metabolic process (GO:0046487)2.49434565
98keratinocyte proliferation (GO:0043616)2.47601288
99L-fucose catabolic process (GO:0042355)2.44669166
100L-fucose metabolic process (GO:0042354)2.44669166

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.20212557
2PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.80275618
3VDR_22108803_ChIP-Seq_LS180_Human3.61918674
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.57652490
5NOTCH1_21737748_ChIP-Seq_TLL_Human2.98471357
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.89216345
7TAF15_26573619_Chip-Seq_HEK293_Human2.81980897
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.79464365
9E2F7_22180533_ChIP-Seq_HELA_Human2.71655335
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.44618404
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.39463284
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.36095594
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.30875768
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.05846011
15PCGF2_27294783_Chip-Seq_NPCs_Mouse2.04665938
16ZNF274_21170338_ChIP-Seq_K562_Hela2.03186828
17FOXM1_23109430_ChIP-Seq_U2OS_Human1.99406297
18E2F4_17652178_ChIP-ChIP_JURKAT_Human1.95327796
19IGF1R_20145208_ChIP-Seq_DFB_Human1.92809036
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.88068137
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87601065
22SOX2_19829295_ChIP-Seq_ESCs_Human1.84395659
23NANOG_19829295_ChIP-Seq_ESCs_Human1.84395659
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.83955514
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82403969
26POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.78206491
27TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78206491
28VDR_23849224_ChIP-Seq_CD4+_Human1.75830504
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75734198
30EWS_26573619_Chip-Seq_HEK293_Human1.72527938
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.67566947
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66804005
33RXR_22108803_ChIP-Seq_LS180_Human1.60516913
34BCAT_22108803_ChIP-Seq_LS180_Human1.60240719
35TP53_22573176_ChIP-Seq_HFKS_Human1.59650956
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59221498
37DCP1A_22483619_ChIP-Seq_HELA_Human1.57096635
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.51245551
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.51195492
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48831980
41AUTS2_25519132_ChIP-Seq_293T-REX_Human1.47249439
42HTT_18923047_ChIP-ChIP_STHdh_Human1.40630770
43CDX2_22108803_ChIP-Seq_LS180_Human1.38294213
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37378680
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.36969824
46FUS_26573619_Chip-Seq_HEK293_Human1.33199493
47GATA3_21878914_ChIP-Seq_MCF-7_Human1.28954494
48ER_23166858_ChIP-Seq_MCF-7_Human1.28945847
49SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.27535081
50IRF1_19129219_ChIP-ChIP_H3396_Human1.27023443
51TCF4_23295773_ChIP-Seq_U87_Human1.25593033
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25322828
53CBP_20019798_ChIP-Seq_JUKART_Human1.25322828
54ELK1_19687146_ChIP-ChIP_HELA_Human1.21659178
55STAT3_23295773_ChIP-Seq_U87_Human1.20401843
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19726114
57CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19726091
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18721520
59MYC_18555785_ChIP-Seq_MESCs_Mouse1.18361336
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17337467
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17052366
62NANOG_20526341_ChIP-Seq_ESCs_Human1.16677737
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16067712
64IRF8_21731497_ChIP-ChIP_J774_Mouse1.15903629
65FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15082714
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14144059
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13367060
68CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10455766
69FOXP3_21729870_ChIP-Seq_TREG_Human1.10155773
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.09332426
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07827803
72FOXH1_21741376_ChIP-Seq_EPCs_Human1.06525433
73EGR1_19032775_ChIP-ChIP_M12_Human1.06396836
74AR_21909140_ChIP-Seq_LNCAP_Human1.05115908
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02354218
76PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02326338
77CBP_21632823_ChIP-Seq_H3396_Human1.01498354
78P300_18555785_Chip-Seq_ESCs_Mouse1.00600446
79GABP_19822575_ChIP-Seq_HepG2_Human1.00030418
80FOXA1_25329375_ChIP-Seq_VCAP_Human0.99712020
81FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99712020
82SMAD1_18555785_Chip-Seq_ESCs_Mouse0.99301881
83PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98619182
84P300_19829295_ChIP-Seq_ESCs_Human0.98203957
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98000404
86ERA_21632823_ChIP-Seq_H3396_Human0.97291004
87HOXB7_26014856_ChIP-Seq_BT474_Human0.96834963
88TP53_16413492_ChIP-PET_HCT116_Human0.95905215
89KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95481397
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95372909
91MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94220641
92TCF4_22108803_ChIP-Seq_LS180_Human0.94215356
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93634808
94FOXH1_21741376_ChIP-Seq_ESCs_Human0.93358040
95STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93295231
96NMYC_18555785_Chip-Seq_ESCs_Mouse0.92632113
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90613304
98CTCF_18555785_Chip-Seq_ESCs_Mouse0.89381795
99GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.88679912
100FLI1_21867929_ChIP-Seq_TH2_Mouse0.87923804

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow4.49257591
2MP0002876_abnormal_thyroid_physiology4.26977930
3MP0009780_abnormal_chondrocyte_physiolo3.98340350
4MP0005360_urolithiasis3.23229030
5MP0000569_abnormal_digit_pigmentation3.07249405
6MP0003183_abnormal_peptide_metabolism3.00024365
7MP0001968_abnormal_touch/_nociception2.86793104
8MP0006035_abnormal_mitochondrial_morpho2.82570939
9MP0003646_muscle_fatigue2.71181290
10MP0005551_abnormal_eye_electrophysiolog2.68014904
11MP0001545_abnormal_hematopoietic_system2.54620357
12MP0005397_hematopoietic_system_phenotyp2.54620357
13MP0010234_abnormal_vibrissa_follicle2.51428353
14MP0006072_abnormal_retinal_apoptosis2.34549644
15MP0005503_abnormal_tendon_morphology2.26340032
16MP0005670_abnormal_white_adipose2.18469814
17MP0008057_abnormal_DNA_replication2.15322533
18MP0010094_abnormal_chromosome_stability2.11209048
19MP0009333_abnormal_splenocyte_physiolog2.09238937
20MP0006036_abnormal_mitochondrial_physio1.93786635
21MP0009764_decreased_sensitivity_to1.86233088
22MP0003941_abnormal_skin_development1.82800114
23MP0004147_increased_porphyrin_level1.80920369
24MP0003806_abnormal_nucleotide_metabolis1.79431487
25MP0000015_abnormal_ear_pigmentation1.74584367
26MP0008872_abnormal_physiological_respon1.74164858
27MP0000681_abnormal_thyroid_gland1.73405846
28MP0000678_abnormal_parathyroid_gland1.70981218
29MP0005645_abnormal_hypothalamus_physiol1.67135251
30MP0003880_abnormal_central_pattern1.55710168
31MP0001881_abnormal_mammary_gland1.55191268
32MP0008058_abnormal_DNA_repair1.54459377
33MP0003693_abnormal_embryo_hatching1.51747619
34MP0002971_abnormal_brown_adipose1.51134979
35MP0002733_abnormal_thermal_nociception1.50316172
36MP0003638_abnormal_response/metabolism_1.47403104
37MP0002095_abnormal_skin_pigmentation1.45912405
38MP0003045_fibrosis1.45065934
39MP0001501_abnormal_sleep_pattern1.37200129
40MP0000685_abnormal_immune_system1.36503240
41MP0009697_abnormal_copulation1.34731660
42MP0003950_abnormal_plasma_membrane1.34098544
43MP0001873_stomach_inflammation1.30677144
44MP0001919_abnormal_reproductive_system1.29893592
45MP0003252_abnormal_bile_duct1.28522691
46MP0005085_abnormal_gallbladder_physiolo1.26010402
47MP0001664_abnormal_digestion1.24146580
48MP0003011_delayed_dark_adaptation1.19502383
49MP0005174_abnormal_tail_pigmentation1.19465340
50MP0004957_abnormal_blastocyst_morpholog1.13342189
51MP0004043_abnormal_pH_regulation1.13105582
52MP0005257_abnormal_intraocular_pressure1.11209569
53MP0001790_abnormal_immune_system1.08908395
54MP0005387_immune_system_phenotype1.08908395
55MP0003195_calcinosis1.07621304
56MP0009745_abnormal_behavioral_response1.06556403
57MP0008775_abnormal_heart_ventricle1.04440047
58MP0005253_abnormal_eye_physiology1.04205970
59MP0003936_abnormal_reproductive_system1.01973517
60MP0000358_abnormal_cell_content/0.99688570
61MP0003718_maternal_effect0.98943437
62MP0008961_abnormal_basal_metabolism0.96246439
63MP0005646_abnormal_pituitary_gland0.93079498
64MP0002148_abnormal_hypersensitivity_rea0.92839541
65MP0001986_abnormal_taste_sensitivity0.90444692
66MP0005310_abnormal_salivary_gland0.90052382
67MP0000627_abnormal_mammary_gland0.89035792
68MP0002160_abnormal_reproductive_system0.84263117
69MP0005389_reproductive_system_phenotype0.83991830
70MP0001486_abnormal_startle_reflex0.83955126
71MP0000427_abnormal_hair_cycle0.83337110
72MP0009046_muscle_twitch0.82741831
73MP0003567_abnormal_fetal_cardiomyocyte0.81600082
74MP0001929_abnormal_gametogenesis0.80597877
75MP0002796_impaired_skin_barrier0.79893842
76MP0003937_abnormal_limbs/digits/tail_de0.79289212
77MP0005365_abnormal_bile_salt0.77854319
78MP0005195_abnormal_posterior_eye0.76039082
79MP0003959_abnormal_lean_body0.75888799
80MP0005671_abnormal_response_to0.75741438
81MP0003077_abnormal_cell_cycle0.75009136
82MP0005410_abnormal_fertilization0.74925620
83MP0003633_abnormal_nervous_system0.73887143
84MP0002938_white_spotting0.73142588
85MP0002254_reproductive_system_inflammat0.72577418
86MP0002272_abnormal_nervous_system0.72099707
87MP0003172_abnormal_lysosome_physiology0.71301814
88MP0002970_abnormal_white_adipose0.70866698
89MP0002332_abnormal_exercise_endurance0.70394519
90MP0004742_abnormal_vestibular_system0.70128507
91MP0009765_abnormal_xenobiotic_induced0.69396840
92MP0002098_abnormal_vibrissa_morphology0.67771320
93MP0008875_abnormal_xenobiotic_pharmacok0.66402555
94MP0003786_premature_aging0.62376807
95MP0005167_abnormal_blood-brain_barrier0.62319266
96MP0001970_abnormal_pain_threshold0.61661234
97MP0010678_abnormal_skin_adnexa0.61596853
98MP0005330_cardiomyopathy0.59983962
99MP0002249_abnormal_larynx_morphology0.58579837
100MP0005332_abnormal_amino_acid0.56536908

Predicted human phenotypes

RankGene SetZ-score
1Thyroid-stimulating hormone excess (HP:0002925)8.74063011
2Volvulus (HP:0002580)6.11476412
3Congenital stationary night blindness (HP:0007642)5.07440969
4Progressive inability to walk (HP:0002505)4.63341294
5Progressive external ophthalmoplegia (HP:0000590)4.54557654
6Intestinal atresia (HP:0011100)4.47073048
7Chromosomal breakage induced by crosslinking agents (HP:0003221)4.42915588
8Pancreatic islet-cell hyperplasia (HP:0004510)4.18631791
9Chromsome breakage (HP:0040012)3.95348055
10Abnormality of the ileum (HP:0001549)3.95123800
11Abnormality of the aortic arch (HP:0012303)3.82611693
12Large for gestational age (HP:0001520)3.76609949
13Sensory axonal neuropathy (HP:0003390)3.57006216
14Oligodontia (HP:0000677)3.44177603
15Clumsiness (HP:0002312)3.39324222
16Poor head control (HP:0002421)3.38283941
17Broad alveolar ridges (HP:0000187)3.22007298
18Thickened helices (HP:0000391)3.03801428
19Prostate neoplasm (HP:0100787)2.98727087
20Tented upper lip vermilion (HP:0010804)2.92435031
21Ragged-red muscle fibers (HP:0003200)2.91693646
22Nephroblastoma (Wilms tumor) (HP:0002667)2.90599256
23Supernumerary spleens (HP:0009799)2.89076825
24Mesangial abnormality (HP:0001966)2.82272289
25Large eyes (HP:0001090)2.81790126
26Inability to walk (HP:0002540)2.75452178
27Embryonal renal neoplasm (HP:0011794)2.75259463
28Congenital ichthyosiform erythroderma (HP:0007431)2.72583488
29Gaze-evoked nystagmus (HP:0000640)2.69882797
30Abnormal pupillary function (HP:0007686)2.65895775
31Tubular atrophy (HP:0000092)2.64360435
32Hypoproteinemia (HP:0003075)2.62273358
33Hypoplasia of the pons (HP:0012110)2.60656009
34Progressive muscle weakness (HP:0003323)2.55343297
35Abnormality of the pons (HP:0007361)2.52823164
36Increased serum lactate (HP:0002151)2.48682314
37Poor speech (HP:0002465)2.48080528
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.46775568
39Focal motor seizures (HP:0011153)2.46016977
40Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.43052695
41Agitation (HP:0000713)2.42663219
42Abnormality of the pancreatic islet cells (HP:0006476)2.42279072
43Abnormality of endocrine pancreas physiology (HP:0012093)2.42279072
44Hyperglycinemia (HP:0002154)2.41340214
45Impaired proprioception (HP:0010831)2.40786744
46Hepatocellular necrosis (HP:0001404)2.35931416
47Neonatal respiratory distress (HP:0002643)2.35609359
48Impulsivity (HP:0100710)2.31627260
49Decreased electroretinogram (ERG) amplitude (HP:0000654)2.25655940
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.24536974
51Premature ovarian failure (HP:0008209)2.22267501
52Broad-based gait (HP:0002136)2.22189331
53Elevated erythrocyte sedimentation rate (HP:0003565)2.21958531
54Epileptic encephalopathy (HP:0200134)2.18383991
55Increased CSF lactate (HP:0002490)2.17429569
56Meckel diverticulum (HP:0002245)2.17010932
57Dysphonia (HP:0001618)2.14826541
58Abnormality of the labia minora (HP:0012880)2.14753136
59Abnormality of the preputium (HP:0100587)2.14689698
60Agammaglobulinemia (HP:0004432)2.14588647
61Proximal tubulopathy (HP:0000114)2.13169857
62Oligodactyly (hands) (HP:0001180)2.12941016
63Hepatic necrosis (HP:0002605)2.12627406
64Pendular nystagmus (HP:0012043)2.10428302
65Aplasia/Hypoplasia of the spleen (HP:0010451)2.09927180
66Asplenia (HP:0001746)2.07808180
67Gastrointestinal atresia (HP:0002589)2.02547343
683-Methylglutaconic aciduria (HP:0003535)2.00475912
69Wide intermamillary distance (HP:0006610)1.99046092
70Cerebellar dysplasia (HP:0007033)1.95735082
71Lissencephaly (HP:0001339)1.91147706
72Acute encephalopathy (HP:0006846)1.89207115
73Increased corneal curvature (HP:0100692)1.88647513
74Keratoconus (HP:0000563)1.88647513
75Duplicated collecting system (HP:0000081)1.88129958
76Chronic sinusitis (HP:0011109)1.87295090
77External ophthalmoplegia (HP:0000544)1.86788213
78Abnormality of glycine metabolism (HP:0010895)1.85212836
79Abnormality of serine family amino acid metabolism (HP:0010894)1.85212836
80Chorioretinal atrophy (HP:0000533)1.82385425
81Pancreatic cysts (HP:0001737)1.81803632
82Fatigue (HP:0012378)1.81660155
83Duodenal stenosis (HP:0100867)1.81561966
84Small intestinal stenosis (HP:0012848)1.81561966
85Hyperglycinuria (HP:0003108)1.80490287
86Acute necrotizing encephalopathy (HP:0006965)1.80195753
87Clubbing of toes (HP:0100760)1.80092965
88Abnormality of the renal collecting system (HP:0004742)1.79587632
89Attenuation of retinal blood vessels (HP:0007843)1.79124203
90Abnormality of chromosome stability (HP:0003220)1.78954455
91Myositis (HP:0100614)1.77936591
92Stomatitis (HP:0010280)1.77650968
93Type II lissencephaly (HP:0007260)1.75975888
94Increased serum pyruvate (HP:0003542)1.75679398
95Mitochondrial inheritance (HP:0001427)1.73579312
96Areflexia of lower limbs (HP:0002522)1.73539320
97Abnormality of midbrain morphology (HP:0002418)1.72213584
98Molar tooth sign on MRI (HP:0002419)1.72213584
99Status epilepticus (HP:0002133)1.71442597
100Embryonal neoplasm (HP:0002898)1.71212203

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK26.03535580
2MST45.99574238
3ADRBK25.48816141
4DYRK34.42556258
5GRK13.62842564
6FRK3.14879469
7ZAK2.87712174
8EIF2AK32.62077702
9MAPKAPK32.34692569
10STK392.27155779
11WNK42.20234942
12EIF2AK12.01695841
13ERN11.89353756
14STK101.66632538
15VRK21.54496007
16ADRBK11.51649539
17PINK11.48494652
18TAF11.38793199
19OXSR11.37582773
20ACVR1B1.33708053
21TSSK61.33223393
22MAPKAPK51.12099688
23TAOK11.06920335
24MAP3K31.06019894
25NUAK11.05789776
26STK161.03523281
27PBK1.01784843
28CDC71.01669003
29NEK11.00049576
30PIK3CG0.97713269
31PIM20.93157515
32PRKCE0.92984371
33RPS6KA40.87428972
34SRPK10.86891510
35TTK0.83913030
36NME20.81152024
37TRPM70.78935614
38NEK90.78820660
39IRAK30.78396206
40EIF2AK20.77760350
41PLK10.77448263
42PNCK0.77057430
43PRKCI0.76386931
44WEE10.76079063
45BMPR1B0.75324437
46PRKCG0.75144255
47TNIK0.74221031
48EEF2K0.72549328
49BUB10.71360806
50MST1R0.70305119
51DAPK10.69588379
52PLK40.67815356
53RIPK10.65007733
54AURKB0.64623256
55MAP3K90.63002473
56PLK30.62012845
57PLK20.60345330
58MAP2K60.60248987
59TGFBR10.58788748
60MAPK110.58513285
61MAP3K80.56733906
62CCNB10.55614346
63VRK10.55011506
64MAPK130.49901853
65IRAK10.48854526
66GRK50.47776187
67MKNK20.47277116
68CAMK1G0.46914961
69ATR0.46539088
70CLK10.46187550
71AKT20.45472357
72MKNK10.45220047
73MAP3K110.42249456
74CAMK1D0.42116306
75RPS6KB20.41479035
76ERBB20.39661771
77CHEK20.39265800
78BRSK10.38658914
79NME10.37928937
80CAMK2A0.37430127
81TEC0.36543880
82CSNK1A1L0.36464176
83CSNK2A20.36304620
84CDK70.36190876
85MAP3K140.33380981
86CHEK10.28686924
87STK38L0.28543690
88ATM0.27641927
89MELK0.25805769
90CSNK2A10.24391594
91STK30.23954969
92NEK20.23431119
93FGFR10.22679926
94ITK0.21589564
95PRKCB0.21345472
96FLT30.18223095
97ABL20.17882928
98CDK190.17204846
99PRKACB0.16134736
100BRSK20.15081590

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.69428796
2Phototransduction_Homo sapiens_hsa047443.66427382
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.25319994
4One carbon pool by folate_Homo sapiens_hsa006702.97281955
5Proteasome_Homo sapiens_hsa030502.74701959
6Basal transcription factors_Homo sapiens_hsa030222.48652953
7Fanconi anemia pathway_Homo sapiens_hsa034602.43897906
8Dorso-ventral axis formation_Homo sapiens_hsa043202.15113203
9Homologous recombination_Homo sapiens_hsa034402.12212310
10RNA polymerase_Homo sapiens_hsa030202.07848264
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.04394141
12Propanoate metabolism_Homo sapiens_hsa006401.96058180
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.91097383
14Sulfur metabolism_Homo sapiens_hsa009201.89947642
15Sulfur relay system_Homo sapiens_hsa041221.79903812
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78611532
17Glutathione metabolism_Homo sapiens_hsa004801.76139514
18Base excision repair_Homo sapiens_hsa034101.75469790
19Linoleic acid metabolism_Homo sapiens_hsa005911.67147593
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.63953949
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.53967714
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.50629589
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47952141
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47614913
25Non-homologous end-joining_Homo sapiens_hsa034501.45781371
26RNA degradation_Homo sapiens_hsa030181.40584628
27Butanoate metabolism_Homo sapiens_hsa006501.38849641
28Graft-versus-host disease_Homo sapiens_hsa053321.38659976
29Tryptophan metabolism_Homo sapiens_hsa003801.33087083
30DNA replication_Homo sapiens_hsa030301.32532412
31Vitamin B6 metabolism_Homo sapiens_hsa007501.29568503
32beta-Alanine metabolism_Homo sapiens_hsa004101.25511109
33Morphine addiction_Homo sapiens_hsa050321.23334710
34Glycerolipid metabolism_Homo sapiens_hsa005611.23147383
35Pyrimidine metabolism_Homo sapiens_hsa002401.19817261
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17481747
37Pyruvate metabolism_Homo sapiens_hsa006201.16268412
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.15009524
39ABC transporters_Homo sapiens_hsa020101.14534732
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14269446
41Purine metabolism_Homo sapiens_hsa002301.13628130
42Primary immunodeficiency_Homo sapiens_hsa053401.12354979
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10609632
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08465026
45Fatty acid degradation_Homo sapiens_hsa000711.05897441
46Caffeine metabolism_Homo sapiens_hsa002321.03510688
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.02769479
48Selenocompound metabolism_Homo sapiens_hsa004501.01790539
49Parkinsons disease_Homo sapiens_hsa050121.00423291
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99684029
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98840451
52Mismatch repair_Homo sapiens_hsa034300.96748534
53Oxidative phosphorylation_Homo sapiens_hsa001900.96605249
54Arachidonic acid metabolism_Homo sapiens_hsa005900.93315153
55Ovarian steroidogenesis_Homo sapiens_hsa049130.92989305
56Sphingolipid metabolism_Homo sapiens_hsa006000.92815781
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92374893
58Nucleotide excision repair_Homo sapiens_hsa034200.87506166
59Regulation of autophagy_Homo sapiens_hsa041400.84944589
60Peroxisome_Homo sapiens_hsa041460.83867444
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.81100658
62Arginine and proline metabolism_Homo sapiens_hsa003300.78495282
63Huntingtons disease_Homo sapiens_hsa050160.75731859
64Ether lipid metabolism_Homo sapiens_hsa005650.75365438
65RNA transport_Homo sapiens_hsa030130.72925545
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70569913
67Metabolic pathways_Homo sapiens_hsa011000.67937905
68mRNA surveillance pathway_Homo sapiens_hsa030150.66709833
69Antigen processing and presentation_Homo sapiens_hsa046120.65940677
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63791475
71Nitrogen metabolism_Homo sapiens_hsa009100.62022144
72Retinol metabolism_Homo sapiens_hsa008300.60544630
73Pentose phosphate pathway_Homo sapiens_hsa000300.59701799
74Hedgehog signaling pathway_Homo sapiens_hsa043400.59605704
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55792690
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.55195231
77Chemical carcinogenesis_Homo sapiens_hsa052040.54538370
78Mineral absorption_Homo sapiens_hsa049780.52044327
79Autoimmune thyroid disease_Homo sapiens_hsa053200.51938424
80Taste transduction_Homo sapiens_hsa047420.49514162
81Allograft rejection_Homo sapiens_hsa053300.49438471
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48290176
83Carbon metabolism_Homo sapiens_hsa012000.47975185
84Alzheimers disease_Homo sapiens_hsa050100.47233021
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46443274
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.45423099
87Histidine metabolism_Homo sapiens_hsa003400.41942023
88Asthma_Homo sapiens_hsa053100.40559949
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38010823
90Folate biosynthesis_Homo sapiens_hsa007900.37234007
91Wnt signaling pathway_Homo sapiens_hsa043100.37165945
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36131075
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35505040
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33049355
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32415584
96Fatty acid metabolism_Homo sapiens_hsa012120.32382276
97Starch and sucrose metabolism_Homo sapiens_hsa005000.32200258
98Type I diabetes mellitus_Homo sapiens_hsa049400.31791839
99Protein export_Homo sapiens_hsa030600.30346288
100p53 signaling pathway_Homo sapiens_hsa041150.26898141

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