RPL24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24E family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as ribosomal protein L30 because the encoded protein shares amino acid identity with the L30 ribosomal proteins from S. cerevisiae; however, its official name is ribosomal protein L24. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* viral transcription (GO:0019083)9.33827021
2* translational termination (GO:0006415)8.98699752
3ribosomal small subunit assembly (GO:0000028)8.93028694
4ribosomal small subunit biogenesis (GO:0042274)8.52552895
5* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.68571401
6* translational elongation (GO:0006414)7.68202664
7* cotranslational protein targeting to membrane (GO:0006613)7.56250246
8* protein targeting to ER (GO:0045047)7.53753745
9maturation of SSU-rRNA (GO:0030490)7.25051723
10* establishment of protein localization to endoplasmic reticulum (GO:0072599)7.19725045
11* protein localization to endoplasmic reticulum (GO:0070972)7.06144096
12* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)7.04298283
13* cellular protein complex disassembly (GO:0043624)6.98677976
14* viral life cycle (GO:0019058)6.97469400
15* translational initiation (GO:0006413)6.80560827
16ribosomal large subunit biogenesis (GO:0042273)6.16638507
17* protein complex disassembly (GO:0043241)6.08980679
18* macromolecular complex disassembly (GO:0032984)5.70877440
19* translation (GO:0006412)5.12756256
20* nuclear-transcribed mRNA catabolic process (GO:0000956)5.05519038
21* protein targeting to membrane (GO:0006612)5.00969055
22ribonucleoprotein complex biogenesis (GO:0022613)4.91355719
23chaperone-mediated protein transport (GO:0072321)4.85896341
24formation of translation preinitiation complex (GO:0001731)4.83033708
25* mRNA catabolic process (GO:0006402)4.78007897
26respiratory electron transport chain (GO:0022904)4.53726165
27phenylpropanoid metabolic process (GO:0009698)4.53507379
28* RNA catabolic process (GO:0006401)4.46156856
29electron transport chain (GO:0022900)4.41858244
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.41725226
31flavonoid metabolic process (GO:0009812)4.30542691
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.19640820
33rRNA processing (GO:0006364)4.01863668
34DNA deamination (GO:0045006)4.01741503
35energy coupled proton transport, down electrochemical gradient (GO:0015985)3.93691656
36ATP synthesis coupled proton transport (GO:0015986)3.93691656
37rRNA metabolic process (GO:0016072)3.86117361
38cellular component biogenesis (GO:0044085)3.80474652
39protein neddylation (GO:0045116)3.70872369
40DNA strand elongation involved in DNA replication (GO:0006271)3.68077321
41proteasome assembly (GO:0043248)3.60707897
42telomere maintenance via semi-conservative replication (GO:0032201)3.54589277
43ATP biosynthetic process (GO:0006754)3.51317921
44* protein localization to membrane (GO:0072657)3.51270199
45mitochondrial respiratory chain complex assembly (GO:0033108)3.50469490
46DNA strand elongation (GO:0022616)3.49002914
47* establishment of protein localization to membrane (GO:0090150)3.41548926
48negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.41440576
49spliceosomal snRNP assembly (GO:0000387)3.37332278
50establishment of integrated proviral latency (GO:0075713)3.35956002
51regulation of mitochondrial translation (GO:0070129)3.35434716
52transcription elongation from RNA polymerase III promoter (GO:0006385)3.30692108
53termination of RNA polymerase III transcription (GO:0006386)3.30692108
54protein complex biogenesis (GO:0070271)3.26886236
55purine nucleoside triphosphate biosynthetic process (GO:0009145)3.22470208
56DNA replication initiation (GO:0006270)3.21343676
57* protein targeting (GO:0006605)3.21307660
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.18574311
59purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.17981227
60spliceosomal complex assembly (GO:0000245)3.17896688
61* establishment of protein localization to organelle (GO:0072594)3.17676759
62establishment of protein localization to mitochondrial membrane (GO:0090151)3.16992188
63negative regulation of ligase activity (GO:0051352)3.15629917
64negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.15629917
65DNA unwinding involved in DNA replication (GO:0006268)3.15273016
66telomere maintenance via recombination (GO:0000722)3.13837543
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.12593482
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.10755958
69ribosome biogenesis (GO:0042254)3.10552898
70DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.09411426
71protein targeting to mitochondrion (GO:0006626)3.07061333
72signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.03446001
73intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.03446001
74signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.99231606
75signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.99231606
76signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.99231606
77ribonucleoside triphosphate biosynthetic process (GO:0009201)2.98470245
78signal transduction involved in DNA integrity checkpoint (GO:0072401)2.97080405
79signal transduction involved in DNA damage checkpoint (GO:0072422)2.97080405
80pseudouridine synthesis (GO:0001522)2.96661492
81ribosome assembly (GO:0042255)2.95647552
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.95368926
83cellular glucuronidation (GO:0052695)2.93278982
84* protein localization to organelle (GO:0033365)2.93034505
85transcription-coupled nucleotide-excision repair (GO:0006283)2.93013767
86UTP biosynthetic process (GO:0006228)2.93002439
87mitotic recombination (GO:0006312)2.92699890
88signal transduction involved in cell cycle checkpoint (GO:0072395)2.92644412
89GTP biosynthetic process (GO:0006183)2.91961224
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.88880086
91nucleobase-containing small molecule interconversion (GO:0015949)2.88150624
92establishment of protein localization to mitochondrion (GO:0072655)2.88114411
93ncRNA 3-end processing (GO:0043628)2.86900910
94termination of RNA polymerase I transcription (GO:0006363)2.85605316
95nucleobase biosynthetic process (GO:0046112)2.84983752
96mitotic chromosome condensation (GO:0007076)2.84698326
97kinetochore organization (GO:0051383)2.84553980
98uronic acid metabolic process (GO:0006063)2.84294285
99glucuronate metabolic process (GO:0019585)2.84294285
100nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.83593324
101transcription elongation from RNA polymerase I promoter (GO:0006362)2.82968520
102hydrogen ion transmembrane transport (GO:1902600)2.82231005
103telomere maintenance via telomere lengthening (GO:0010833)2.81905667
104CENP-A containing nucleosome assembly (GO:0034080)2.81656797
105regulation of cellular amino acid metabolic process (GO:0006521)2.81457860
106rRNA modification (GO:0000154)2.80518836
1077-methylguanosine mRNA capping (GO:0006370)2.80244021
108antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.78548054
109negative regulation of RNA splicing (GO:0033119)2.77989793
110DNA replication checkpoint (GO:0000076)2.77445188
111nucleotide-excision repair, DNA gap filling (GO:0006297)2.76713646
112transcription from mitochondrial promoter (GO:0006390)2.76622817
113mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.76215700
114mitochondrial respiratory chain complex I assembly (GO:0032981)2.76215700
115NADH dehydrogenase complex assembly (GO:0010257)2.76215700
116deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.75591311
117chromatin remodeling at centromere (GO:0031055)2.75540121
118RNA capping (GO:0036260)2.75513867
1197-methylguanosine RNA capping (GO:0009452)2.75513867
120ncRNA processing (GO:0034470)2.75468969
121protein localization to mitochondrion (GO:0070585)2.75091765
122DNA damage response, detection of DNA damage (GO:0042769)2.74331491
123purine nucleoside monophosphate biosynthetic process (GO:0009127)2.73883889
124purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.73883889
125positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.73774319
126oxidative phosphorylation (GO:0006119)2.72894859
127establishment of viral latency (GO:0019043)2.72578499
128mitotic metaphase plate congression (GO:0007080)2.72052096
129transcription from RNA polymerase I promoter (GO:0006360)2.70356095
130* gene expression (GO:0010467)2.67659590
131nucleoside triphosphate biosynthetic process (GO:0009142)2.66320161
132* cellular component disassembly (GO:0022411)2.64884700
133purine nucleobase biosynthetic process (GO:0009113)2.63847760
134protein localization to kinetochore (GO:0034501)2.63485228
135positive regulation of ligase activity (GO:0051351)2.62179935
136guanosine-containing compound biosynthetic process (GO:1901070)2.61928294
137G1/S transition of mitotic cell cycle (GO:0000082)2.60833981

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.80016926
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.94913536
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.32585721
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.08659402
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.65945448
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.63589859
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.53931457
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.41325944
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.29595273
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.06426477
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.00229277
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.97761692
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.95028891
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.88557316
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.83488362
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.82907035
17* XRN2_22483619_ChIP-Seq_HELA_Human2.78337045
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60046268
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.52685018
20* VDR_23849224_ChIP-Seq_CD4+_Human2.45502342
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34367241
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27325776
23* TTF2_22483619_ChIP-Seq_HELA_Human2.26874988
24DCP1A_22483619_ChIP-Seq_HELA_Human2.23163946
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.22684804
26* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.21715209
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.16283062
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15179067
29* ELK1_19687146_ChIP-ChIP_HELA_Human2.10855748
30* FOXP3_21729870_ChIP-Seq_TREG_Human2.01233044
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95666600
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94947632
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.88347804
34* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82313540
35GABP_19822575_ChIP-Seq_HepG2_Human1.81785425
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74403757
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68973163
38* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65563346
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.60727478
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59367482
41* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59239765
42ESR1_15608294_ChIP-ChIP_MCF-7_Human1.52480110
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52324988
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52026378
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.49635987
46CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49290496
47* ELK1_22589737_ChIP-Seq_MCF10A_Human1.49222234
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47101543
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46947148
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.46620194
51* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44498784
52KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.43363021
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.39292762
54AR_21909140_ChIP-Seq_LNCAP_Human1.38433160
55* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36620324
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35865870
57CIITA_25753668_ChIP-Seq_RAJI_Human1.35275193
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32815251
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30119734
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27086848
61TP63_17297297_ChIP-ChIP_HaCaT_Human1.26187224
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25018185
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.24212208
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23627078
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22579370
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21545937
67KDM5A_27292631_Chip-Seq_BREAST_Human1.20372718
68ZNF263_19887448_ChIP-Seq_K562_Human1.17317526
69MYC_18940864_ChIP-ChIP_HL60_Human1.17104894
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16873721
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14237971
72MYC_22102868_ChIP-Seq_BL_Human1.13677624
73CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.13416919
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13264744
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12895210
76* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08910464
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07834812
78SPI1_23547873_ChIP-Seq_NB4_Human1.06681744
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.06568075
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06256392
81VDR_21846776_ChIP-Seq_THP-1_Human1.05943979
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04103260
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02992697
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01335031
85OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00869853
86SOX2_16153702_ChIP-ChIP_HESCs_Human0.99437430
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99138468
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98518003
89SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98078656
90TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97178714
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96533466
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96335640
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96221721
94TFEB_21752829_ChIP-Seq_HELA_Human0.95567431
95SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94746764
96HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94391300
97EGR1_19374776_ChIP-ChIP_THP-1_Human0.94371689
98RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94184023
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.93284781
100PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92038984
101MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89523771
102PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.89405490
103SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89347773
104TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.88715304
105E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87529281
106GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84539605
107SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81917709
108IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.81550119
109KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.81187174
110NANOG_16153702_ChIP-ChIP_HESCs_Human0.80621236
111TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.80487120
112CTCF_18555785_ChIP-Seq_MESCs_Mouse0.79384595
113ELF5_23300383_ChIP-Seq_T47D_Human0.79217341
114SOX17_20123909_ChIP-Seq_XEN_Mouse0.78896753
115* FOXP1_21924763_ChIP-Seq_HESCs_Human0.78621542
116* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.77546687
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76152941

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.01256412
2MP0003693_abnormal_embryo_hatching4.89754559
3MP0004957_abnormal_blastocyst_morpholog4.07272774
4MP0010094_abnormal_chromosome_stability3.12768839
5* MP0003077_abnormal_cell_cycle3.07893798
6MP0003111_abnormal_nucleus_morphology2.97920707
7MP0008057_abnormal_DNA_replication2.79243767
8MP0008932_abnormal_embryonic_tissue2.51815373
9MP0008058_abnormal_DNA_repair2.29418030
10MP0002396_abnormal_hematopoietic_system2.26192720
11MP0008007_abnormal_cellular_replicative2.21232446
12MP0000566_synostosis2.01646417
13MP0003786_premature_aging1.83845018
14MP0003123_paternal_imprinting1.82723831
15MP0009333_abnormal_splenocyte_physiolog1.82461099
16MP0000490_abnormal_crypts_of1.80668182
17MP0003567_abnormal_fetal_cardiomyocyte1.76870606
18MP0000350_abnormal_cell_proliferation1.71083825
19MP0001730_embryonic_growth_arrest1.69888768
20* MP0002938_white_spotting1.62381676
21MP0010352_gastrointestinal_tract_polyps1.58477616
22MP0009697_abnormal_copulation1.51130887
23MP0003315_abnormal_perineum_morphology1.50425958
24MP0002697_abnormal_eye_size1.48155024
25MP0003136_yellow_coat_color1.47574258
26MP0004808_abnormal_hematopoietic_stem1.44845561
27MP0003938_abnormal_ear_development1.44384579
28MP0010030_abnormal_orbit_morphology1.42855203
29MP0002160_abnormal_reproductive_system1.42849627
30MP0003763_abnormal_thymus_physiology1.41901124
31MP0006054_spinal_hemorrhage1.40849562
32MP0003186_abnormal_redox_activity1.38761373
33MP0002132_abnormal_respiratory_system1.35463383
34MP0003718_maternal_effect1.30972560
35MP0001346_abnormal_lacrimal_gland1.28514525
36MP0002019_abnormal_tumor_incidence1.25442356
37MP0001529_abnormal_vocalization1.24709100
38MP0000858_altered_metastatic_potential1.24142374
39MP0003941_abnormal_skin_development1.23988348
40MP0003937_abnormal_limbs/digits/tail_de1.21880121
41MP0005174_abnormal_tail_pigmentation1.21708931
42MP0002249_abnormal_larynx_morphology1.21382591
43* MP0001697_abnormal_embryo_size1.20952350
44MP0006035_abnormal_mitochondrial_morpho1.19980370
45* MP0002080_prenatal_lethality1.19919511
46* MP0000313_abnormal_cell_death1.17694405
47MP0000631_abnormal_neuroendocrine_gland1.15884539
48MP0009250_abnormal_appendicular_skeleto1.13903304
49MP0001853_heart_inflammation1.13704476
50MP0002398_abnormal_bone_marrow1.13264448
51MP0000537_abnormal_urethra_morphology1.13197366
52MP0005380_embryogenesis_phenotype1.11135665
53MP0001672_abnormal_embryogenesis/_devel1.11135665
54MP0000703_abnormal_thymus_morphology1.10738523
55MP0002722_abnormal_immune_system1.10665473
56* MP0001286_abnormal_eye_development1.07374255
57MP0002095_abnormal_skin_pigmentation1.06838659
58MP0002085_abnormal_embryonic_tissue1.06068699
59MP0000750_abnormal_muscle_regeneration1.05821843
60MP0003755_abnormal_palate_morphology1.05649007
61MP0005394_taste/olfaction_phenotype1.03940803
62MP0005499_abnormal_olfactory_system1.03940803
63MP0005397_hematopoietic_system_phenotyp1.02994715
64MP0001545_abnormal_hematopoietic_system1.02994715
65MP0001835_abnormal_antigen_presentation1.01082307
66MP0003942_abnormal_urinary_system0.99554593
67MP0000689_abnormal_spleen_morphology0.98117128
68MP0003984_embryonic_growth_retardation0.97278461
69MP0004197_abnormal_fetal_growth/weight/0.97230420
70MP0002429_abnormal_blood_cell0.96535425
71MP0002088_abnormal_embryonic_growth/wei0.96261736
72MP0005501_abnormal_skin_physiology0.96245887
73MP0002277_abnormal_respiratory_mucosa0.94914742
74MP0002282_abnormal_trachea_morphology0.94261457
75MP0002210_abnormal_sex_determination0.93417838
76MP0002084_abnormal_developmental_patter0.92537148
77MP0002092_abnormal_eye_morphology0.92012317
78MP0001340_abnormal_eyelid_morphology0.91504456
79MP0002086_abnormal_extraembryonic_tissu0.91476299
80MP0009785_altered_susceptibility_to0.90929289
81MP0002148_abnormal_hypersensitivity_rea0.90859420
82MP0001293_anophthalmia0.90054447
83MP0001800_abnormal_humoral_immune0.89755049
84MP0002405_respiratory_system_inflammati0.89460026
85MP0005408_hypopigmentation0.89000304
86MP0004133_heterotaxia0.88728072
87MP0000678_abnormal_parathyroid_gland0.88613626
88MP0001905_abnormal_dopamine_level0.87461251
89MP0004381_abnormal_hair_follicle0.87358147
90MP0006072_abnormal_retinal_apoptosis0.87117767
91MP0000716_abnormal_immune_system0.87075650
92MP0004142_abnormal_muscle_tone0.86642792
93MP0001881_abnormal_mammary_gland0.86505705
94MP0009053_abnormal_anal_canal0.85889820
95MP0002420_abnormal_adaptive_immunity0.85011329
96MP0000685_abnormal_immune_system0.84976020
97MP0002163_abnormal_gland_morphology0.84898348
98MP0000358_abnormal_cell_content/0.84714034
99MP0001819_abnormal_immune_cell0.83413360
100MP0000049_abnormal_middle_ear0.83200042
101MP0002006_tumorigenesis0.82852458
102MP0005023_abnormal_wound_healing0.82325223
103MP0003806_abnormal_nucleotide_metabolis0.80676200
104MP0005671_abnormal_response_to0.80323823
105MP0002452_abnormal_antigen_presenting0.80024567
106MP0002233_abnormal_nose_morphology0.79815511
107MP0003890_abnormal_embryonic-extraembry0.79608902
108MP0002166_altered_tumor_susceptibility0.79021478
109MP0001727_abnormal_embryo_implantation0.78858835
110MP0005025_abnormal_response_to0.78214688
111MP0006036_abnormal_mitochondrial_physio0.78020934
112MP0005389_reproductive_system_phenotype0.77797352
113MP0002102_abnormal_ear_morphology0.77769504
114MP0006292_abnormal_olfactory_placode0.77232514
115* MP0003861_abnormal_nervous_system0.76728676
116MP0002723_abnormal_immune_serum0.74966129
117MP0005075_abnormal_melanosome_morpholog0.74884910
118MP0005391_vision/eye_phenotype0.73993950
119MP0000372_irregular_coat_pigmentation0.73604369
120MP0000762_abnormal_tongue_morphology0.72781981
121MP0002796_impaired_skin_barrier0.72068931
122MP0008877_abnormal_DNA_methylation0.71700207
123MP0005000_abnormal_immune_tolerance0.71109397
124MP0003121_genomic_imprinting0.70918131
125MP0002116_abnormal_craniofacial_bone0.70866066
126MP0003448_altered_tumor_morphology0.69332277
127MP0002751_abnormal_autonomic_nervous0.69277931
128MP0001145_abnormal_male_reproductive0.69173333
129MP0003436_decreased_susceptibility_to0.66259826
130MP0008789_abnormal_olfactory_epithelium0.65921917
131MP0003283_abnormal_digestive_organ0.65819916
132MP0010155_abnormal_intestine_physiology0.65732684
133MP0002928_abnormal_bile_duct0.65696904
134MP0000465_gastrointestinal_hemorrhage0.65360560
135MP0008995_early_reproductive_senescence0.64727631
136MP0002098_abnormal_vibrissa_morphology0.64419457
137* MP0002111_abnormal_tail_morphology0.64372315
138MP0003011_delayed_dark_adaptation0.64059919
139MP0008875_abnormal_xenobiotic_pharmacok0.63825922
140MP0002234_abnormal_pharynx_morphology0.62636800
141MP0003936_abnormal_reproductive_system0.60306679
142MP0000653_abnormal_sex_gland0.59184037
143MP0001485_abnormal_pinna_reflex0.57966567
144MP0001929_abnormal_gametogenesis0.57702630
145MP0000778_abnormal_nervous_system0.57606601

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)9.09953706
2Reticulocytopenia (HP:0001896)8.00153475
3Abnormal number of erythroid precursors (HP:0012131)7.98244278
4Macrocytic anemia (HP:0001972)6.08105854
5Pallor (HP:0000980)5.58894402
6Colon cancer (HP:0003003)3.48126067
7Aplasia/Hypoplasia of the sacrum (HP:0008517)3.43569471
8Acute necrotizing encephalopathy (HP:0006965)3.35839579
9Cerebral edema (HP:0002181)3.30071361
10Increased hepatocellular lipid droplets (HP:0006565)3.28497900
11Mitochondrial inheritance (HP:0001427)3.16746484
12Multiple enchondromatosis (HP:0005701)3.15802042
13Thrombocytosis (HP:0001894)3.05419666
14Aplastic anemia (HP:0001915)3.02628822
15Abnormal hemoglobin (HP:0011902)2.99847397
1611 pairs of ribs (HP:0000878)2.96952026
17Oral leukoplakia (HP:0002745)2.96082165
18Breast hypoplasia (HP:0003187)2.94491611
19Stenosis of the external auditory canal (HP:0000402)2.94118847
20Trismus (HP:0000211)2.89397095
21Absent thumb (HP:0009777)2.89261558
22Abnormal mitochondria in muscle tissue (HP:0008316)2.88221713
23Birth length less than 3rd percentile (HP:0003561)2.83306862
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.79049047
25Lipid accumulation in hepatocytes (HP:0006561)2.76660565
26Increased CSF lactate (HP:0002490)2.72163072
27Abnormality of reticulocytes (HP:0004312)2.71782149
28Exertional dyspnea (HP:0002875)2.70912878
29Congenital, generalized hypertrichosis (HP:0004540)2.67880666
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.64201150
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.64201150
32Progressive macrocephaly (HP:0004481)2.63905692
33Hepatocellular necrosis (HP:0001404)2.63018335
34Depressed nasal ridge (HP:0000457)2.62835697
35Abnormality of renal resorption (HP:0011038)2.62208780
36Rough bone trabeculation (HP:0100670)2.62083036
37Septo-optic dysplasia (HP:0100842)2.61309265
38Testicular atrophy (HP:0000029)2.57922478
39Carpal bone hypoplasia (HP:0001498)2.54199871
40Leukodystrophy (HP:0002415)2.54133800
41Hypoplastic pelvis (HP:0008839)2.50783186
42Lactic acidosis (HP:0003128)2.45318298
43Acute encephalopathy (HP:0006846)2.43424311
443-Methylglutaconic aciduria (HP:0003535)2.38766465
45Renal Fanconi syndrome (HP:0001994)2.37022349
46Selective tooth agenesis (HP:0001592)2.34289713
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.33818678
48Respiratory difficulties (HP:0002880)2.32665154
49Glossoptosis (HP:0000162)2.32340807
50Hypoplasia of the radius (HP:0002984)2.26954621
51Patellar aplasia (HP:0006443)2.21582812
52Rib fusion (HP:0000902)2.21086878
53Hepatic necrosis (HP:0002605)2.20672730
54Triphalangeal thumb (HP:0001199)2.15422105
55Aplasia/Hypoplasia of the patella (HP:0006498)2.13716738
56Thick lower lip vermilion (HP:0000179)2.12601136
57Generalized aminoaciduria (HP:0002909)2.12512250
58Reduced antithrombin III activity (HP:0001976)2.12076838
59Microretrognathia (HP:0000308)2.07905057
60Increased serum lactate (HP:0002151)2.06570729
61Premature graying of hair (HP:0002216)2.05242984
62Increased intramyocellular lipid droplets (HP:0012240)2.04788377
63Migraine (HP:0002076)2.04581778
64Atresia of the external auditory canal (HP:0000413)2.04058168
65Exercise intolerance (HP:0003546)2.03997329
66Abnormality of methionine metabolism (HP:0010901)2.02975096
67Megaloblastic anemia (HP:0001889)2.01891855
68Cleft eyelid (HP:0000625)2.01878831
69Absent septum pellucidum (HP:0001331)2.00454617
70Abnormality of urine glucose concentration (HP:0011016)1.98444469
71Glycosuria (HP:0003076)1.98444469
72IgM deficiency (HP:0002850)1.97858573
73Partial duplication of the phalanx of hand (HP:0009999)1.96727090
74Hyperphosphaturia (HP:0003109)1.96390310
75Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.95815289
76Asplenia (HP:0001746)1.95570080
77Optic disc pallor (HP:0000543)1.94800424
78Abnormal trabecular bone morphology (HP:0100671)1.93879204
79Partial duplication of thumb phalanx (HP:0009944)1.93443461
80Neoplasm of the pancreas (HP:0002894)1.92335733
81Nasolacrimal duct obstruction (HP:0000579)1.91878082
82Abnormality of the septum pellucidum (HP:0007375)1.90235188
83Missing ribs (HP:0000921)1.90018511
84Abnormal number of incisors (HP:0011064)1.88752136
85Type I transferrin isoform profile (HP:0003642)1.88703350
86Horseshoe kidney (HP:0000085)1.87261541
87Sparse eyelashes (HP:0000653)1.87032061
88Respiratory failure (HP:0002878)1.86902332
89Degeneration of anterior horn cells (HP:0002398)1.83746182
90Abnormality of the anterior horn cell (HP:0006802)1.83746182
91Absent radius (HP:0003974)1.83471698
92Gout (HP:0001997)1.83174117
93Cerebral hypomyelination (HP:0006808)1.82046280
94Aplasia/Hypoplasia of the spleen (HP:0010451)1.80152027
95Myelodysplasia (HP:0002863)1.78416108
96Patent foramen ovale (HP:0001655)1.78312252
97Woolly hair (HP:0002224)1.77975531
98Cellular immunodeficiency (HP:0005374)1.77111948
99Myokymia (HP:0002411)1.76497940
100Concave nail (HP:0001598)1.75736837
101Secondary amenorrhea (HP:0000869)1.75029556
102Abnormality of the parietal bone (HP:0002696)1.74637268
103Abnormality of the preputium (HP:0100587)1.73009972
104Hyperthyroidism (HP:0000836)1.71697012
105Forearm undergrowth (HP:0009821)1.68394608
106Absent forearm bone (HP:0003953)1.68272163
107Aplasia involving forearm bones (HP:0009822)1.68272163
108Supernumerary bones of the axial skeleton (HP:0009144)1.68119859
109Abnormal urine phosphate concentration (HP:0012599)1.68016367
110Meckel diverticulum (HP:0002245)1.67742212
111Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.67274580
112Maternal diabetes (HP:0009800)1.66991447
113Pancytopenia (HP:0001876)1.66402228
114Lethargy (HP:0001254)1.66161435
115Homocystinuria (HP:0002156)1.64294747
116Abnormality of homocysteine metabolism (HP:0010919)1.64294747
117Abnormality of the fetal cardiovascular system (HP:0010948)1.63791449
118Abnormal umbilical cord blood vessels (HP:0011403)1.63791449
119Single umbilical artery (HP:0001195)1.63791449
120Abnormality of the ileum (HP:0001549)1.63597759
121Abnormal lung lobation (HP:0002101)1.61926891
122Renal tubular dysfunction (HP:0000124)1.61275203
123Congenital ichthyosiform erythroderma (HP:0007431)1.59728122
124Muscle fiber atrophy (HP:0100295)1.59524251
125Increased muscle lipid content (HP:0009058)1.59281302
126Abnormality of secondary sexual hair (HP:0009888)1.58698890
127Abnormality of the axillary hair (HP:0100134)1.58698890
128Elevated erythrocyte sedimentation rate (HP:0003565)1.58586987
129Premature ovarian failure (HP:0008209)1.58418423
130Petechiae (HP:0000967)1.58121479
131Sparse lateral eyebrow (HP:0005338)1.57572770
132Abnormality of the lacrimal duct (HP:0011481)1.57164958
133Abnormality of the umbilical cord (HP:0010881)1.56691500
134Poor head control (HP:0002421)1.56200093
135X-linked dominant inheritance (HP:0001423)1.55277367
136Abnormality of placental membranes (HP:0011409)1.54323024
137Amniotic constriction ring (HP:0009775)1.54323024
138Abnormality of cochlea (HP:0000375)1.54084839
139Decreased subcutaneous fat (HP:0001002)1.53664445
140Short nose (HP:0003196)1.50479015
141Hypoplasia of the ulna (HP:0003022)1.50254265
142Abnormality of subcutaneous fat tissue (HP:0001001)1.50138828
143Increased serum pyruvate (HP:0003542)1.49528741
144Abnormality of aspartate family amino acid metabolism (HP:0010899)1.49451700
145Median cleft lip (HP:0000161)1.48999324
146Neoplasm of head and neck (HP:0012288)1.47271058

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.76675896
2VRK24.44671382
3BUB14.00442644
4WEE13.74089879
5ARAF2.72884797
6STK162.70809799
7SRPK12.56855473
8RPS6KB22.44678898
9EIF2AK12.43009356
10CDC72.26234950
11TLK12.21237339
12VRK12.20156354
13LRRK22.13186933
14PIM22.10420710
15MAP3K122.04756750
16MST42.00701464
17TGFBR11.79808954
18EIF2AK31.77129438
19DYRK31.76952274
20PASK1.75911853
21RPS6KA41.74821247
22BRSK21.70052495
23MKNK11.67025270
24TESK21.61626837
25AURKB1.53445163
26NEK21.50136020
27NME11.49992353
28CDK71.43227265
29TAF11.42438935
30TSSK61.40377417
31EEF2K1.37394347
32PLK41.33057010
33ILK1.32528672
34EPHA21.30616198
35PLK11.29971518
36ACVR1B1.28085784
37MAP4K11.17415381
38KDR1.17090128
39BMPR1B1.10993691
40MAPK151.09618089
41PBK1.06256654
42PAK41.05722124
43AURKA1.03754390
44PNCK1.01582298
45MAP3K81.00355660
46TTK0.99668002
47STK100.99065987
48PIM10.95264805
49ATR0.92695056
50CSNK2A20.89546780
51MKNK20.87065327
52CDK190.85155357
53RPS6KA50.83536959
54PLK30.83273730
55CDK40.82043055
56MAP3K30.81345943
57CSNK1E0.81326711
58CSNK2A10.80567092
59TESK10.79523117
60PAK10.77668963
61BTK0.77360226
62LIMK10.77091958
63NEK10.77090014
64TEC0.76899678
65MAP2K30.76790970
66FLT30.75453431
67CDK90.74594574
68STK40.74051012
69SMG10.73806482
70LATS20.73289821
71CHEK20.73022960
72DYRK20.72530017
73BRSK10.69126555
74NUAK10.67785925
75BLK0.67658401
76MAPKAPK30.67555940
77EIF2AK20.67390738
78MAP3K110.67017159
79CHEK10.66908349
80CDK80.61828483
81IKBKB0.61243429
82AKT20.60753148
83ZAP700.59001746
84ABL20.57938559
85SCYL20.53830903
86MAP3K90.53715538
87MAP3K100.53568821
88PAK20.53501116
89ZAK0.52588780
90PRKCI0.52053246
91STK240.51396608
92GRK60.51156265
93CDK10.50730836
94MYLK0.50016043
95MAP2K20.48802644
96PDK20.47887683
97KIT0.47809634
98NLK0.45661680
99CDK30.45523489
100CCNB10.44578280
101TYK20.44349984
102CDK11A0.44246094
103CDK20.43434979
104DMPK0.42789659
105ATM0.41933542
106DAPK30.41546589
107CLK10.41401002
108CDK60.40866877
109LYN0.38240187
110PKN20.38191622
111EPHB20.37584785
112MAPKAPK20.33557624
113BRAF0.33319380
114RPS6KL10.33073968
115RPS6KC10.33073968
116ERBB40.32793198
117PRKDC0.32395708
118RPS6KA60.31806103
119TXK0.31426176
120DYRK1B0.31084346
121UHMK10.29962906
122BCKDK0.29825089
123WNK40.29775413
124RPS6KA10.29648845
125MELK0.28655921
126LCK0.28468730
127SYK0.28408231
128PRKACB0.27055667
129PTK60.25421049
130CDK150.23231492
131MAPK140.22546490
132TNIK0.22544310
133ICK0.20436329
134CDK140.19752371

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030107.38919436
2Proteasome_Homo sapiens_hsa030503.92389100
3DNA replication_Homo sapiens_hsa030303.71639764
4RNA polymerase_Homo sapiens_hsa030203.50518576
5Mismatch repair_Homo sapiens_hsa034303.12645786
6Spliceosome_Homo sapiens_hsa030403.09187246
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.79534769
8Oxidative phosphorylation_Homo sapiens_hsa001902.45948693
9Pyrimidine metabolism_Homo sapiens_hsa002402.42451059
10RNA transport_Homo sapiens_hsa030132.39357551
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.39248943
12Nucleotide excision repair_Homo sapiens_hsa034202.38699839
13Parkinsons disease_Homo sapiens_hsa050122.33902884
14Homologous recombination_Homo sapiens_hsa034402.32604949
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28728256
16Base excision repair_Homo sapiens_hsa034102.14214988
17Protein export_Homo sapiens_hsa030601.91753904
18Huntingtons disease_Homo sapiens_hsa050161.86940937
19One carbon pool by folate_Homo sapiens_hsa006701.67043400
20Cell cycle_Homo sapiens_hsa041101.63801845
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54307134
22Basal transcription factors_Homo sapiens_hsa030221.54244311
23RNA degradation_Homo sapiens_hsa030181.52821303
24Non-homologous end-joining_Homo sapiens_hsa034501.51988216
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50721336
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.47991960
27Alzheimers disease_Homo sapiens_hsa050101.46925135
28Fanconi anemia pathway_Homo sapiens_hsa034601.40614702
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.34478002
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.32100397
31p53 signaling pathway_Homo sapiens_hsa041151.20974022
32Purine metabolism_Homo sapiens_hsa002301.15288624
33Chemical carcinogenesis_Homo sapiens_hsa052041.14502376
34Epstein-Barr virus infection_Homo sapiens_hsa051691.08375893
35mRNA surveillance pathway_Homo sapiens_hsa030151.08357470
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01849602
37Systemic lupus erythematosus_Homo sapiens_hsa053220.96545834
38Retinol metabolism_Homo sapiens_hsa008300.95616826
39Starch and sucrose metabolism_Homo sapiens_hsa005000.91875223
40Primary immunodeficiency_Homo sapiens_hsa053400.88421599
41Sulfur relay system_Homo sapiens_hsa041220.87235856
42Antigen processing and presentation_Homo sapiens_hsa046120.84321754
43Herpes simplex infection_Homo sapiens_hsa051680.77998855
44Folate biosynthesis_Homo sapiens_hsa007900.75963489
45Glutathione metabolism_Homo sapiens_hsa004800.74738462
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74147188
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71920625
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66399893
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64128678
50Cardiac muscle contraction_Homo sapiens_hsa042600.63770533
51Pentose phosphate pathway_Homo sapiens_hsa000300.60557576
52Viral carcinogenesis_Homo sapiens_hsa052030.60218595
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.59361993
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56721515
55Hematopoietic cell lineage_Homo sapiens_hsa046400.56291700
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55518816
57Legionellosis_Homo sapiens_hsa051340.54877677
58Pyruvate metabolism_Homo sapiens_hsa006200.52589576
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50121169
60HTLV-I infection_Homo sapiens_hsa051660.50015087
61Allograft rejection_Homo sapiens_hsa053300.48594322
62Asthma_Homo sapiens_hsa053100.47774840
63Graft-versus-host disease_Homo sapiens_hsa053320.47367480
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46562996
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46138975
66Thyroid cancer_Homo sapiens_hsa052160.44622125
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.43762283
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43252229
69Arachidonic acid metabolism_Homo sapiens_hsa005900.42992202
70Small cell lung cancer_Homo sapiens_hsa052220.42811990
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40053881
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.40039125
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.39881488
74Mineral absorption_Homo sapiens_hsa049780.39757536
75Measles_Homo sapiens_hsa051620.38022940
76Basal cell carcinoma_Homo sapiens_hsa052170.36605060
77Metabolic pathways_Homo sapiens_hsa011000.34374092
78Apoptosis_Homo sapiens_hsa042100.34255959
79Shigellosis_Homo sapiens_hsa051310.33451193
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33188070
81Galactose metabolism_Homo sapiens_hsa000520.33178829
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.32817426
83N-Glycan biosynthesis_Homo sapiens_hsa005100.32656059
84Fructose and mannose metabolism_Homo sapiens_hsa000510.30439152
85Wnt signaling pathway_Homo sapiens_hsa043100.30026525
86TGF-beta signaling pathway_Homo sapiens_hsa043500.29335525
87Alcoholism_Homo sapiens_hsa050340.28131714
88Tyrosine metabolism_Homo sapiens_hsa003500.27923454
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27694056
90MicroRNAs in cancer_Homo sapiens_hsa052060.26901515
91Vitamin digestion and absorption_Homo sapiens_hsa049770.26878383
92Autoimmune thyroid disease_Homo sapiens_hsa053200.26311161
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26233936
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25718371
95Viral myocarditis_Homo sapiens_hsa054160.25531130
96Bladder cancer_Homo sapiens_hsa052190.23672109
97Collecting duct acid secretion_Homo sapiens_hsa049660.22431390
98Oocyte meiosis_Homo sapiens_hsa041140.22142457
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21835640
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21790172
101HIF-1 signaling pathway_Homo sapiens_hsa040660.21175014
102Biosynthesis of amino acids_Homo sapiens_hsa012300.21058043
103Pathways in cancer_Homo sapiens_hsa052000.20985700
104Leishmaniasis_Homo sapiens_hsa051400.20211984
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.20092754
106Hepatitis B_Homo sapiens_hsa051610.19314984
107Hippo signaling pathway_Homo sapiens_hsa043900.17928613
108Propanoate metabolism_Homo sapiens_hsa006400.17375371
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16723584
110Renal cell carcinoma_Homo sapiens_hsa052110.15162906
111Hedgehog signaling pathway_Homo sapiens_hsa043400.14949351
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.14728890
113Acute myeloid leukemia_Homo sapiens_hsa052210.13624743
114Linoleic acid metabolism_Homo sapiens_hsa005910.13301936
115Malaria_Homo sapiens_hsa051440.13230322
116Selenocompound metabolism_Homo sapiens_hsa004500.12842303
117Notch signaling pathway_Homo sapiens_hsa043300.12173957
118Carbon metabolism_Homo sapiens_hsa012000.11814463
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11052032
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.11044783
121Influenza A_Homo sapiens_hsa051640.10257005
122Vibrio cholerae infection_Homo sapiens_hsa051100.10168237
123Pertussis_Homo sapiens_hsa051330.09811628
124Peroxisome_Homo sapiens_hsa041460.09567466
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.09540743
126Regulation of autophagy_Homo sapiens_hsa041400.09348909
127Steroid biosynthesis_Homo sapiens_hsa001000.06753680
128Sulfur metabolism_Homo sapiens_hsa009200.01460830
129Vitamin B6 metabolism_Homo sapiens_hsa00750-0.0768479
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250-0.0624315
131Maturity onset diabetes of the young_Homo sapiens_hsa04950-0.0387364
132Caffeine metabolism_Homo sapiens_hsa00232-0.0383445
133Fatty acid elongation_Homo sapiens_hsa00062-0.0132242
134Arginine and proline metabolism_Homo sapiens_hsa00330-0.0108443
135Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280-0.0008831

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