ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	8.32059975
2	translational termination (GO:0006415)	7.97995538
3	ribosomal small subunit biogenesis (GO:0042274)	7.45815956
4	ribosomal small subunit assembly (GO:0000028)	7.21629339
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.01426396
6	cotranslational protein targeting to membrane (GO:0006613)	6.93265948
7	ATP synthesis coupled proton transport (GO:0015986)	6.90120745
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.90120745
9	protein targeting to ER (GO:0045047)	6.89071739
10	translational elongation (GO:0006414)	6.76618446
11	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.62637651
12	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.62470603
13	protein localization to endoplasmic reticulum (GO:0070972)	6.52972273
14	cellular protein complex disassembly (GO:0043624)	6.11286541
15	viral life cycle (GO:0019058)	6.08543463
16	chaperone-mediated protein transport (GO:0072321)	5.83373961
17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.80229513
18	maturation of SSU-rRNA (GO:0030490)	5.55233491
19	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.54062252
20	translational initiation (GO:0006413)	5.46914246
21	ribosomal large subunit biogenesis (GO:0042273)	5.33720625
22	protein complex disassembly (GO:0043241)	5.17388804
23	respiratory electron transport chain (GO:0022904)	5.12775116
24	protein neddylation (GO:0045116)	5.07077097
25	electron transport chain (GO:0022900)	5.04756681
26	macromolecular complex disassembly (GO:0032984)	4.99518195
27	translation (GO:0006412)	4.95174003
28	protein complex biogenesis (GO:0070271)	4.82097347
29	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.69728829
30	protein targeting to membrane (GO:0006612)	4.68931612
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.68433313
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.68433313
33	NADH dehydrogenase complex assembly (GO:0010257)	4.68433313
34	mitochondrial respiratory chain complex assembly (GO:0033108)	4.64343852
35	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.08874198
36	cellular component biogenesis (GO:0044085)	4.06415459
37	ribonucleoprotein complex biogenesis (GO:0022613)	4.05265616
38	DNA deamination (GO:0045006)	4.05190034
39	ATP biosynthetic process (GO:0006754)	3.98016086
40	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.93473961
41	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.91206422
42	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.90618320
43	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.90618320
44	mRNA catabolic process (GO:0006402)	3.86173321
45	hydrogen ion transmembrane transport (GO:1902600)	3.80592388
46	GTP biosynthetic process (GO:0006183)	3.79090563
47	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.71802924
48	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.69574967
49	behavioral response to nicotine (GO:0035095)	3.66769149
50	respiratory chain complex IV assembly (GO:0008535)	3.65935411
51	CTP metabolic process (GO:0046036)	3.54791063
52	CTP biosynthetic process (GO:0006241)	3.54791063
53	RNA catabolic process (GO:0006401)	3.47108609
54	protein targeting to mitochondrion (GO:0006626)	3.39955427
55	substrate-independent telencephalic tangential migration (GO:0021826)	3.35671920
56	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.35671920
57	proton transport (GO:0015992)	3.32979516
58	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.29874461
59	termination of RNA polymerase III transcription (GO:0006386)	3.29874461
60	cytochrome complex assembly (GO:0017004)	3.28738245
61	protein targeting (GO:0006605)	3.27861491
62	establishment of protein localization to membrane (GO:0090150)	3.26146372
63	establishment of protein localization to mitochondrion (GO:0072655)	3.25951103
64	nucleoside triphosphate biosynthetic process (GO:0009142)	3.25846714
65	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.24800208
66	hydrogen transport (GO:0006818)	3.24413259
67	UTP biosynthetic process (GO:0006228)	3.24153166
68	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.20200621
69	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.19621243
70	pyrimidine nucleotide catabolic process (GO:0006244)	3.18705092
71	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.17063205
72	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.16464027
73	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.16403426
74	protein localization to mitochondrion (GO:0070585)	3.08525816
75	water-soluble vitamin biosynthetic process (GO:0042364)	3.07680817
76	rRNA processing (GO:0006364)	3.06382190
77	organelle disassembly (GO:1903008)	3.05132048
78	base-excision repair, AP site formation (GO:0006285)	3.03326045
79	protein-cofactor linkage (GO:0018065)	3.01699028
80	UTP metabolic process (GO:0046051)	2.99338246
81	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.98584041
82	rRNA metabolic process (GO:0016072)	2.98139865
83	nucleotide salvage (GO:0043173)	2.93780961
84	ncRNA 3-end processing (GO:0043628)	2.88959663
85	establishment of protein localization to organelle (GO:0072594)	2.88295397
86	guanosine-containing compound biosynthetic process (GO:1901070)	2.85317369
87	iron-sulfur cluster assembly (GO:0016226)	2.79265520
88	metallo-sulfur cluster assembly (GO:0031163)	2.79265520
89	intracellular protein transmembrane import (GO:0044743)	2.76895134
90	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.75121515
91	nucleoside salvage (GO:0043174)	2.75057269
92	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.74241028
93	mitochondrial transport (GO:0006839)	2.66799883
94	ribonucleoprotein complex disassembly (GO:0032988)	2.65413216
95	tRNA processing (GO:0008033)	2.64845969
96	response to redox state (GO:0051775)	2.63676451
97	peptidyl-histidine modification (GO:0018202)	2.63434997
98	parturition (GO:0007567)	2.58644726
99	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	2.57823891
100	protein localization to membrane (GO:0072657)	2.56391569

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.63642653
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.32011190
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.82672954
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.76549809
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.70195787
6	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.49444023
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.35965251
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.28612222
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.24560996
10	EZH2_22144423_ChIP-Seq_EOC_Human	3.20275869
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.04227657
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.02989341
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.59432653
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.59183657
15	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.48335935
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.42989188
17	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.37467115
18	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.31954060
19	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.31445677
20	FOXP3_21729870_ChIP-Seq_TREG_Human	2.25649748
21	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.22956382
22	ELK1_19687146_ChIP-ChIP_HELA_Human	2.22836732
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.16282702
24	XRN2_22483619_ChIP-Seq_HELA_Human	2.10071714
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.04954322
26	TTF2_22483619_ChIP-Seq_HELA_Human	2.00878586
27	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.99429616
28	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.96255306
29	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.93305532
30	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.90976027
31	GABP_19822575_ChIP-Seq_HepG2_Human	1.88357673
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.83803126
33	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.80348660
34	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.68310212
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.58676420
36	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.58656142
37	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.54221919
38	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.46644714
39	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.44452969
40	VDR_22108803_ChIP-Seq_LS180_Human	1.43435639
41	ZNF274_21170338_ChIP-Seq_K562_Hela	1.43099188
42	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.41750255
43	DCP1A_22483619_ChIP-Seq_HELA_Human	1.37719887
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.34944413
45	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.33180864
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.31498659
47	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.24152465
48	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.21995552
49	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.20633886
50	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.19273391
51	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.11263139
52	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.08478367
53	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.07154810
54	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.06797777
55	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.04430811
56	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.04370931
57	ERA_21632823_ChIP-Seq_H3396_Human	1.04073884
58	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.03053668
59	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.02127998
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.02123087
61	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.01458579
62	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.00977234
63	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.00885738
64	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.00553022
65	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.00239235
66	NCOR_22424771_ChIP-Seq_293T_Human	1.00095216
67	TAF2_19829295_ChIP-Seq_ESCs_Human	0.99144499
68	IGF1R_20145208_ChIP-Seq_DFB_Human	0.96967632
69	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.96957560
70	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96952631
71	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.96802134
72	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.95811462
73	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.95098271
74	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.94599206
75	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.92230078
76	CTCF_20526341_ChIP-Seq_ESCs_Human	0.91862975
77	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.91807750
78	KDM5A_27292631_Chip-Seq_BREAST_Human	0.91162754
79	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.91091935
80	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.90370736
81	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.89502239
82	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.89284176
83	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.89284176
84	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.88645908
85	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.88301515
86	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.86178341
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.84885047
88	AR_20517297_ChIP-Seq_VCAP_Human	0.84088284
89	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.83853980
90	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.81908955
91	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.80537833
92	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.80462643
93	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.79883970
94	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.79734165
95	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.79689755
96	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.79093586
97	BCL6_27268052_Chip-Seq_Bcells_Human	0.78852527
98	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.78057949
99	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.77810334
100	REST_21632747_ChIP-Seq_MESCs_Mouse	0.77046479

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.77456991
2	MP0006292_abnormal_olfactory_placode	3.88422248
3	MP0003806_abnormal_nucleotide_metabolis	3.22959862
4	MP0003787_abnormal_imprinting	3.14107695
5	MP0002163_abnormal_gland_morphology	2.98650073
6	MP0002638_abnormal_pupillary_reflex	2.74662939
7	MP0003123_paternal_imprinting	2.48320999
8	MP0003646_muscle_fatigue	2.24486479
9	MP0008789_abnormal_olfactory_epithelium	2.18400405
10	MP0003122_maternal_imprinting	2.16552659
11	MP0004142_abnormal_muscle_tone	2.12040569
12	MP0008875_abnormal_xenobiotic_pharmacok	2.09828418
13	MP0003121_genomic_imprinting	2.08266384
14	MP0006276_abnormal_autonomic_nervous	2.04494045
15	MP0008877_abnormal_DNA_methylation	2.02341851
16	MP0003186_abnormal_redox_activity	1.95947941
17	MP0002938_white_spotting	1.87082835
18	MP0002837_dystrophic_cardiac_calcinosis	1.84373536
19	MP0005379_endocrine/exocrine_gland_phen	1.80706301
20	MP0002102_abnormal_ear_morphology	1.77156771
21	MP0005646_abnormal_pituitary_gland	1.75195945
22	MP0001529_abnormal_vocalization	1.69858191
23	MP0005394_taste/olfaction_phenotype	1.67729086
24	MP0005499_abnormal_olfactory_system	1.67729086
25	MP0001905_abnormal_dopamine_level	1.65879713
26	MP0000049_abnormal_middle_ear	1.61464086
27	MP0006036_abnormal_mitochondrial_physio	1.58065580
28	MP0001968_abnormal_touch/_nociception	1.55387966
29	MP0006072_abnormal_retinal_apoptosis	1.52343505
30	MP0004145_abnormal_muscle_electrophysio	1.49022363
31	MP0004885_abnormal_endolymph	1.47216033
32	MP0004147_increased_porphyrin_level	1.45771626
33	MP0002160_abnormal_reproductive_system	1.44979580
34	MP0003880_abnormal_central_pattern	1.44826808
35	MP0001188_hyperpigmentation	1.44320544
36	MP0005423_abnormal_somatic_nervous	1.38643815
37	MP0005389_reproductive_system_phenotype	1.35083904
38	MP0000372_irregular_coat_pigmentation	1.34923174
39	MP0002653_abnormal_ependyma_morphology	1.34207595
40	MP0002736_abnormal_nociception_after	1.33919153
41	MP0005551_abnormal_eye_electrophysiolog	1.33353944
42	MP0001986_abnormal_taste_sensitivity	1.30639231
43	MP0008872_abnormal_physiological_respon	1.29764028
44	MP0009745_abnormal_behavioral_response	1.27443279
45	MP0002272_abnormal_nervous_system	1.26647901
46	MP0001984_abnormal_olfaction	1.24001173
47	MP0001293_anophthalmia	1.23397113
48	MP0002095_abnormal_skin_pigmentation	1.23182999
49	MP0002876_abnormal_thyroid_physiology	1.19819458
50	MP0005645_abnormal_hypothalamus_physiol	1.19778321
51	MP0001970_abnormal_pain_threshold	1.17906088
52	MP0001919_abnormal_reproductive_system	1.17023594
53	MP0000631_abnormal_neuroendocrine_gland	1.16800980
54	MP0009046_muscle_twitch	1.16699711
55	MP0005671_abnormal_response_to	1.16195624
56	MP0002735_abnormal_chemical_nociception	1.15963178
57	MP0008058_abnormal_DNA_repair	1.15854636
58	MP0001440_abnormal_grooming_behavior	1.15430775
59	MP0002733_abnormal_thermal_nociception	1.15121807
60	MP0002234_abnormal_pharynx_morphology	1.13476195
61	MP0003011_delayed_dark_adaptation	1.10870603
62	MP0005084_abnormal_gallbladder_morpholo	1.07226448
63	MP0002277_abnormal_respiratory_mucosa	1.02540769
64	MP0005195_abnormal_posterior_eye	0.98793059
65	MP0005377_hearing/vestibular/ear_phenot	0.98536145
66	MP0003878_abnormal_ear_physiology	0.98536145
67	MP0002822_catalepsy	0.96820316
68	MP0001485_abnormal_pinna_reflex	0.93665430
69	MP0006035_abnormal_mitochondrial_morpho	0.92982040
70	MP0002752_abnormal_somatic_nervous	0.92284527
71	MP0002184_abnormal_innervation	0.90705982
72	MP0003718_maternal_effect	0.88904296
73	MP0002572_abnormal_emotion/affect_behav	0.88433250
74	MP0005253_abnormal_eye_physiology	0.87308285
75	MP0002557_abnormal_social/conspecific_i	0.83870740
76	MP0005075_abnormal_melanosome_morpholog	0.83530407
77	MP0000778_abnormal_nervous_system	0.79195825
78	MP0004742_abnormal_vestibular_system	0.77524610
79	MP0000026_abnormal_inner_ear	0.74281038
80	MP0001963_abnormal_hearing_physiology	0.74106955
81	MP0001486_abnormal_startle_reflex	0.73813402
82	MP0005670_abnormal_white_adipose	0.73068731
83	MP0005636_abnormal_mineral_homeostasis	0.72867485
84	MP0005332_abnormal_amino_acid	0.71846511
85	MP0001542_abnormal_bone_strength	0.71406362
86	MP0003136_yellow_coat_color	0.71344099
87	MP0002064_seizures	0.70940609
88	MP0009764_decreased_sensitivity_to	0.69663038
89	MP0002148_abnormal_hypersensitivity_rea	0.69646416
90	MP0003786_premature_aging	0.68819891
91	MP0005410_abnormal_fertilization	0.68492925
92	MP0002067_abnormal_sensory_capabilities	0.68019519
93	MP0002063_abnormal_learning/memory/cond	0.67550729
94	MP0002210_abnormal_sex_determination	0.65340573
95	MP0001764_abnormal_homeostasis	0.65305258
96	MP0000955_abnormal_spinal_cord	0.64900713
97	MP0003693_abnormal_embryo_hatching	0.62540468
98	MP0003879_abnormal_hair_cell	0.62529256
99	MP0002734_abnormal_mechanical_nocicepti	0.61179502
100	MP0003635_abnormal_synaptic_transmissio	0.60623003

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	6.21072884
2	Abnormal mitochondria in muscle tissue (HP:0008316)	5.72245726
3	Acute encephalopathy (HP:0006846)	5.28478486
4	Mitochondrial inheritance (HP:0001427)	5.19760580
5	Progressive macrocephaly (HP:0004481)	5.05210291
6	Abnormality of cells of the erythroid lineage (HP:0012130)	4.96998149
7	Increased CSF lactate (HP:0002490)	4.57267277
8	Increased hepatocellular lipid droplets (HP:0006565)	4.42457795
9	Reticulocytopenia (HP:0001896)	4.29704734
10	3-Methylglutaconic aciduria (HP:0003535)	4.27721460
11	Macrocytic anemia (HP:0001972)	4.16000464
12	Lipid accumulation in hepatocytes (HP:0006561)	4.08856837
13	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.03147838
14	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.03147838
15	Hepatocellular necrosis (HP:0001404)	4.02781720
16	Abnormal number of erythroid precursors (HP:0012131)	4.02042677
17	Renal Fanconi syndrome (HP:0001994)	3.98946309
18	Increased intramyocellular lipid droplets (HP:0012240)	3.86302747
19	Cerebral edema (HP:0002181)	3.85281841
20	Hepatic necrosis (HP:0002605)	3.81151267
21	Increased muscle lipid content (HP:0009058)	3.24701182
22	Molar tooth sign on MRI (HP:0002419)	3.23164037
23	Abnormality of midbrain morphology (HP:0002418)	3.23164037
24	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.18857544
25	Pallor (HP:0000980)	3.17204752
26	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.01787105
27	Lactic acidosis (HP:0003128)	2.95798364
28	Optic disc pallor (HP:0000543)	2.94905334
29	Increased serum lactate (HP:0002151)	2.93402015
30	Exertional dyspnea (HP:0002875)	2.87996936
31	Myokymia (HP:0002411)	2.87032926
32	Abnormality of renal resorption (HP:0011038)	2.85320428
33	Stenosis of the external auditory canal (HP:0000402)	2.84548618
34	Respiratory failure (HP:0002878)	2.77329801
35	Pancreatic cysts (HP:0001737)	2.73867815
36	Leukodystrophy (HP:0002415)	2.70808181
37	Exercise intolerance (HP:0003546)	2.68268996
38	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.61006802
39	Congenital stationary night blindness (HP:0007642)	2.59533727
40	Pancreatic fibrosis (HP:0100732)	2.56450985
41	Absent thumb (HP:0009777)	2.47720661
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.42939564
43	Lethargy (HP:0001254)	2.41232695
44	Respiratory difficulties (HP:0002880)	2.40682678
45	Abnormality of urine glucose concentration (HP:0011016)	2.40378083
46	Glycosuria (HP:0003076)	2.40378083
47	Hyperglycinemia (HP:0002154)	2.39880706
48	Generalized aminoaciduria (HP:0002909)	2.22266103
49	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.18512676
50	Methylmalonic acidemia (HP:0002912)	2.17024150
51	Congenital, generalized hypertrichosis (HP:0004540)	2.16361788
52	Medial flaring of the eyebrow (HP:0010747)	2.15332144
53	Sclerocornea (HP:0000647)	2.12189388
54	Hyperphosphaturia (HP:0003109)	2.07804481
55	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.07096012
56	True hermaphroditism (HP:0010459)	2.06194052
57	Asplenia (HP:0001746)	2.05812710
58	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.05545212
59	Abnormality of alanine metabolism (HP:0010916)	2.05545212
60	Hyperalaninemia (HP:0003348)	2.05545212
61	X-linked dominant inheritance (HP:0001423)	2.02037663
62	Nephronophthisis (HP:0000090)	1.98831855
63	Rib fusion (HP:0000902)	1.97827712
64	Abnormal hemoglobin (HP:0011902)	1.94892486
65	Abnormality of the renal cortex (HP:0011035)	1.93559667
66	Pendular nystagmus (HP:0012043)	1.92426674
67	Type 2 muscle fiber atrophy (HP:0003554)	1.89644366
68	Methylmalonic aciduria (HP:0012120)	1.88989997
69	Cerebral hypomyelination (HP:0006808)	1.87577245
70	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.86751417
71	Absent/shortened dynein arms (HP:0200106)	1.86751417
72	Depressed nasal ridge (HP:0000457)	1.84081173
73	CNS demyelination (HP:0007305)	1.80537192
74	Poor suck (HP:0002033)	1.77159176
75	Adrenal hypoplasia (HP:0000835)	1.76367153
76	Hyperthyroidism (HP:0000836)	1.76324168
77	Septo-optic dysplasia (HP:0100842)	1.75871629
78	Gait imbalance (HP:0002141)	1.75431068
79	Polydipsia (HP:0001959)	1.73430819
80	Abnormal drinking behavior (HP:0030082)	1.73430819
81	Abnormality of magnesium homeostasis (HP:0004921)	1.71657311
82	Hypoplasia of the radius (HP:0002984)	1.69753111
83	Testicular atrophy (HP:0000029)	1.69559363
84	Abnormal ciliary motility (HP:0012262)	1.68943945
85	Abnormal respiratory epithelium morphology (HP:0012253)	1.68743959
86	Abnormal respiratory motile cilium morphology (HP:0005938)	1.68743959
87	Abnormal respiratory motile cilium physiology (HP:0012261)	1.68725575
88	Muscle fiber atrophy (HP:0100295)	1.66615498
89	Abnormality of the renal medulla (HP:0100957)	1.66560154
90	Nephrogenic diabetes insipidus (HP:0009806)	1.66228206
91	Congenital primary aphakia (HP:0007707)	1.65435607
92	Abnormal urine phosphate concentration (HP:0012599)	1.63726467
93	Parakeratosis (HP:0001036)	1.62795965
94	Renal cortical cysts (HP:0000803)	1.62635872
95	Decreased central vision (HP:0007663)	1.61814790
96	Cystic liver disease (HP:0006706)	1.61257060
97	Blindness (HP:0000618)	1.60340511
98	Vomiting (HP:0002013)	1.60296781
99	Emotional lability (HP:0000712)	1.58579151
100	Abnormality of serum amino acid levels (HP:0003112)	1.58270012

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	3.91331058
2	LIMK1	3.55866848
3	BCKDK	2.67602504
4	MAP4K2	2.64503114
5	NME2	2.62095539
6	ADRBK2	2.31794900
7	DYRK2	2.25031839
8	WNK4	2.14894347
9	VRK2	1.94218769
10	GRK1	1.92023932
11	TIE1	1.91047541
12	CDK19	1.77482007
13	MAP3K12	1.74352027
14	BRAF	1.65353577
15	TLK1	1.62718543
16	TXK	1.62352578
17	CAMKK2	1.61839157
18	BMPR1B	1.60502625
19	ARAF	1.54495832
20	PIM2	1.52779929
21	NUAK1	1.52682338
22	WNK3	1.47962995
23	ZAK	1.46725826
24	SRPK1	1.43037714
25	KDR	1.30804408
26	PLK4	1.28232271
27	VRK1	1.20681710
28	PINK1	1.19432412
29	CDC7	1.19276265
30	NEK1	1.18432933
31	CSNK1G3	1.14742143
32	PDK2	1.14050670
33	AURKA	1.10014703
34	MAP3K11	1.08883485
35	ABL2	1.08605289
36	MAP2K7	1.07375763
37	TESK2	1.04556109
38	CDK8	1.04201315
39	PRKCG	1.02159334
40	CSNK1G2	0.99960696
41	RPS6KA5	0.97911230
42	INSRR	0.95371311
43	STK39	0.93315145
44	CSNK2A2	0.92287722
45	LRRK2	0.90796957
46	CSNK1G1	0.90379717
47	TAOK3	0.89891608
48	ADRBK1	0.88567587
49	OXSR1	0.87472931
50	CSNK1A1L	0.86010227
51	MINK1	0.83510472
52	TESK1	0.81788694
53	PIK3CA	0.80406210
54	AKT3	0.80375184
55	MAP3K4	0.77233223
56	DAPK3	0.74640359
57	NME1	0.74188653
58	AURKB	0.73051735
59	PRKCQ	0.72187829
60	CSNK2A1	0.72036203
61	PHKG1	0.71282664
62	PHKG2	0.71282664
63	PAK1	0.69766874
64	GRK7	0.69440378
65	FRK	0.68263574
66	MAPK13	0.67981399
67	PASK	0.67899547
68	ILK	0.67888183
69	TEC	0.65624806
70	PLK1	0.64489865
71	TNK2	0.63763678
72	ITK	0.62814026
73	PRKACA	0.62561549
74	DYRK3	0.62270675
75	CAMK1	0.62211402
76	MYLK	0.61889885
77	PRKCI	0.61299266
78	MARK1	0.57229784
79	MAP4K1	0.55756534
80	CSNK1A1	0.55569174
81	EPHB2	0.54768319
82	EIF2AK1	0.53394622
83	CAMKK1	0.53175336
84	CSNK1E	0.53086532
85	PAK3	0.53058733
86	OBSCN	0.50852826
87	IKBKB	0.47980109
88	DYRK1B	0.47678494
89	BRSK1	0.47456352
90	PRKCA	0.46848576
91	ATR	0.46083771
92	MST4	0.44369853
93	PRKCD	0.44162071
94	NTRK2	0.43477339
95	CCNB1	0.41371095
96	MAPKAPK5	0.39117729
97	BMPR2	0.38738183
98	CAMK2A	0.38084892
99	DAPK1	0.35416912
100	CAMK2D	0.34668903

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.70587886
2	Oxidative phosphorylation_Homo sapiens_hsa00190	5.07506303
3	Parkinsons disease_Homo sapiens_hsa05012	4.29493719
4	Alzheimers disease_Homo sapiens_hsa05010	2.90565943
5	Huntingtons disease_Homo sapiens_hsa05016	2.86097022
6	Proteasome_Homo sapiens_hsa03050	2.85399803
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.71035078
8	Protein export_Homo sapiens_hsa03060	2.66725785
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.54357495
10	RNA polymerase_Homo sapiens_hsa03020	2.29777664
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.90019752
12	Pyrimidine metabolism_Homo sapiens_hsa00240	1.69280733
13	Asthma_Homo sapiens_hsa05310	1.63131719
14	Sulfur relay system_Homo sapiens_hsa04122	1.60181883
15	DNA replication_Homo sapiens_hsa03030	1.56186414
16	Homologous recombination_Homo sapiens_hsa03440	1.51281601
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.50980205
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.48514724
19	Basal transcription factors_Homo sapiens_hsa03022	1.38439756
20	RNA degradation_Homo sapiens_hsa03018	1.32466230
21	Mismatch repair_Homo sapiens_hsa03430	1.31253217
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.29692658
23	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.24011003
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.19135981
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.19096916
26	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.16819213
27	Base excision repair_Homo sapiens_hsa03410	1.13778831
28	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.11015879
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.06410752
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.05985059
31	Sulfur metabolism_Homo sapiens_hsa00920	1.05862507
32	Collecting duct acid secretion_Homo sapiens_hsa04966	1.04579768
33	One carbon pool by folate_Homo sapiens_hsa00670	1.04550325
34	Phototransduction_Homo sapiens_hsa04744	1.04210154
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.04044823
36	Allograft rejection_Homo sapiens_hsa05330	1.04000172
37	Spliceosome_Homo sapiens_hsa03040	1.03674786
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.03027749
39	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.01618644
40	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.00623967
41	Chemical carcinogenesis_Homo sapiens_hsa05204	0.99420619
42	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.95362337
43	Purine metabolism_Homo sapiens_hsa00230	0.91520117
44	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.91494245
45	Graft-versus-host disease_Homo sapiens_hsa05332	0.90473929
46	Propanoate metabolism_Homo sapiens_hsa00640	0.83372456
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.82957279
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.81441128
49	Type I diabetes mellitus_Homo sapiens_hsa04940	0.80624957
50	Peroxisome_Homo sapiens_hsa04146	0.80353088
51	Primary immunodeficiency_Homo sapiens_hsa05340	0.79805046
52	Metabolic pathways_Homo sapiens_hsa01100	0.79724067
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.76970255
54	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.76769110
55	Retinol metabolism_Homo sapiens_hsa00830	0.74788228
56	RNA transport_Homo sapiens_hsa03013	0.73950141
57	Butanoate metabolism_Homo sapiens_hsa00650	0.73754304
58	Rheumatoid arthritis_Homo sapiens_hsa05323	0.70354668
59	Caffeine metabolism_Homo sapiens_hsa00232	0.68900285
60	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.67821064
61	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.66778851
62	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.66475611
63	Regulation of autophagy_Homo sapiens_hsa04140	0.62241427
64	Glutathione metabolism_Homo sapiens_hsa00480	0.61788098
65	Nicotine addiction_Homo sapiens_hsa05033	0.60874370
66	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.60034689
67	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.56707123
68	Tryptophan metabolism_Homo sapiens_hsa00380	0.54095731
69	Olfactory transduction_Homo sapiens_hsa04740	0.52081902
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.49072830
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.46210331
72	Steroid biosynthesis_Homo sapiens_hsa00100	0.45435174
73	beta-Alanine metabolism_Homo sapiens_hsa00410	0.44450636
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.43915562
75	Folate biosynthesis_Homo sapiens_hsa00790	0.43114627
76	Pyruvate metabolism_Homo sapiens_hsa00620	0.42912151
77	Mineral absorption_Homo sapiens_hsa04978	0.42672389
78	Antigen processing and presentation_Homo sapiens_hsa04612	0.42095829
79	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.41895828
80	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.41099888
81	Tyrosine metabolism_Homo sapiens_hsa00350	0.37739127
82	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.34777609
83	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.32234461
84	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.32196260
85	Nitrogen metabolism_Homo sapiens_hsa00910	0.29199894
86	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.28449514
87	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.27586546
88	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.25879581
89	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.25493546
90	Fatty acid elongation_Homo sapiens_hsa00062	0.24019237
91	Fatty acid degradation_Homo sapiens_hsa00071	0.19512898
92	Morphine addiction_Homo sapiens_hsa05032	0.17340108
93	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.15402853
94	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.14223553
95	Arginine and proline metabolism_Homo sapiens_hsa00330	0.14147771
96	Serotonergic synapse_Homo sapiens_hsa04726	0.13811968
97	Viral myocarditis_Homo sapiens_hsa05416	0.12755012
98	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.11398235
99	Taste transduction_Homo sapiens_hsa04742	0.11296849
100	GABAergic synapse_Homo sapiens_hsa04727	0.08300084

RPL24P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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