RPL24P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)8.34481725
2translational termination (GO:0006415)8.00005651
3ribosomal small subunit assembly (GO:0000028)7.82548720
4ribosomal small subunit biogenesis (GO:0042274)7.52609466
5chaperone-mediated protein transport (GO:0072321)7.09349372
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.07274250
7energy coupled proton transport, down electrochemical gradient (GO:0015985)6.91835325
8ATP synthesis coupled proton transport (GO:0015986)6.91835325
9translational elongation (GO:0006414)6.83712997
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.79064610
11cotranslational protein targeting to membrane (GO:0006613)6.70000914
12protein targeting to ER (GO:0045047)6.66887670
13establishment of protein localization to endoplasmic reticulum (GO:0072599)6.38341716
14maturation of SSU-rRNA (GO:0030490)6.29137658
15protein localization to endoplasmic reticulum (GO:0070972)6.23598175
16cellular protein complex disassembly (GO:0043624)6.10841922
17viral life cycle (GO:0019058)6.00246735
18establishment of protein localization to mitochondrial membrane (GO:0090151)5.77131198
19nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.74045865
20translational initiation (GO:0006413)5.30413540
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.29173379
22protein neddylation (GO:0045116)5.06643392
23protein complex disassembly (GO:0043241)5.01338287
24DNA deamination (GO:0045006)4.96008274
25behavioral response to nicotine (GO:0035095)4.95869595
26respiratory electron transport chain (GO:0022904)4.95075843
27electron transport chain (GO:0022900)4.91423593
28macromolecular complex disassembly (GO:0032984)4.69544166
29ribosomal large subunit biogenesis (GO:0042273)4.58179820
30translation (GO:0006412)4.44922128
31protein targeting to membrane (GO:0006612)4.42832139
32cytidine deamination (GO:0009972)4.14441426
33cytidine metabolic process (GO:0046087)4.14441426
34cytidine catabolic process (GO:0006216)4.14441426
35regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.11214395
36ATP biosynthetic process (GO:0006754)4.06467758
37protein complex biogenesis (GO:0070271)4.02025794
38nuclear-transcribed mRNA catabolic process (GO:0000956)3.91320356
39purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.86508101
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.84767519
41NADH dehydrogenase complex assembly (GO:0010257)3.84767519
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.84767519
43purine nucleoside triphosphate biosynthetic process (GO:0009145)3.82340342
44pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.79158219
45mRNA catabolic process (GO:0006402)3.66509194
46mitochondrial respiratory chain complex assembly (GO:0033108)3.61904625
47ribonucleoprotein complex biogenesis (GO:0022613)3.58903525
48cellular component biogenesis (GO:0044085)3.54000034
49hydrogen ion transmembrane transport (GO:1902600)3.48397967
50pyrimidine ribonucleoside catabolic process (GO:0046133)3.39526485
51ribonucleoside triphosphate biosynthetic process (GO:0009201)3.29160607
52GTP biosynthetic process (GO:0006183)3.23302522
53RNA catabolic process (GO:0006401)3.23060287
54rRNA processing (GO:0006364)3.13180633
55proton transport (GO:0015992)3.11478474
56hydrogen transport (GO:0006818)3.04445033
57rRNA metabolic process (GO:0016072)3.02468528
58pyrimidine nucleotide catabolic process (GO:0006244)2.99839752
59establishment of protein localization to membrane (GO:0090150)2.99431687
60water-soluble vitamin biosynthetic process (GO:0042364)2.91718546
61sequestering of actin monomers (GO:0042989)2.89433496
62intracellular protein transmembrane import (GO:0044743)2.87682610
63nucleoside triphosphate biosynthetic process (GO:0009142)2.85144427
64protein targeting (GO:0006605)2.83908638
65tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.83231229
66RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.83231229
67base-excision repair, AP site formation (GO:0006285)2.81029149
68inner mitochondrial membrane organization (GO:0007007)2.78138925
69pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.74125208
70positive regulation of prostaglandin secretion (GO:0032308)2.72963390
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69341749
72protein-cofactor linkage (GO:0018065)2.69062575
73UTP biosynthetic process (GO:0006228)2.67043343
74negative regulation of telomere maintenance (GO:0032205)2.66681641
75protein targeting to mitochondrion (GO:0006626)2.62157628
76positive regulation of fatty acid transport (GO:2000193)2.60294081
77establishment of protein localization to organelle (GO:0072594)2.60154524
78exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.59328701
79UTP metabolic process (GO:0046051)2.57117122
80establishment of protein localization to mitochondrion (GO:0072655)2.53668242
81mitochondrial transport (GO:0006839)2.51075815
82response to gravity (GO:0009629)2.48987444
83deoxyribonucleotide catabolic process (GO:0009264)2.47750986
84ncRNA 3-end processing (GO:0043628)2.46657554
85deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.46238101
86transmission of nerve impulse (GO:0019226)2.45759635
87positive regulation of icosanoid secretion (GO:0032305)2.40351111
88protein localization to membrane (GO:0072657)2.40336179
89cell proliferation in forebrain (GO:0021846)2.37209115
90purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.34550157
91purine nucleoside monophosphate biosynthetic process (GO:0009127)2.34550157
92platelet dense granule organization (GO:0060155)2.33362861
93pseudouridine synthesis (GO:0001522)2.33210201
94neurofilament cytoskeleton organization (GO:0060052)2.29274958
95protein localization to mitochondrion (GO:0070585)2.29243569
96termination of RNA polymerase III transcription (GO:0006386)2.28364507
97transcription elongation from RNA polymerase III promoter (GO:0006385)2.28364507
98response to pheromone (GO:0019236)2.27297844
99deoxyribose phosphate catabolic process (GO:0046386)2.26447850
100protein polyglutamylation (GO:0018095)2.26185753

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.71667420
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.40783924
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.98552430
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.97831481
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.81832339
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.25819960
7VDR_22108803_ChIP-Seq_LS180_Human3.16169397
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.72613323
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.69237901
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.41072243
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.26215173
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.14334564
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.12231629
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08087340
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00258501
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94809361
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83678111
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.80262973
19EED_16625203_ChIP-ChIP_MESCs_Mouse1.79343063
20VDR_23849224_ChIP-Seq_CD4+_Human1.76732276
21CBX2_27304074_Chip-Seq_ESCs_Mouse1.74554356
22ZNF274_21170338_ChIP-Seq_K562_Hela1.70918732
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63637584
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62539060
25TP53_22573176_ChIP-Seq_HFKS_Human1.60817159
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.55153075
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53123206
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51233658
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48287627
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47031426
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46063541
32IRF1_19129219_ChIP-ChIP_H3396_Human1.46024078
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45590101
34ELK1_19687146_ChIP-ChIP_HELA_Human1.45499425
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.44884124
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.43747433
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.40397338
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38957469
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38791524
40FUS_26573619_Chip-Seq_HEK293_Human1.37258443
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36998380
42MYC_18940864_ChIP-ChIP_HL60_Human1.36664958
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33033983
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28880119
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28826112
46RNF2_27304074_Chip-Seq_NSC_Mouse1.28113766
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27972307
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.27289836
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26675691
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26501849
51FOXP3_21729870_ChIP-Seq_TREG_Human1.26284249
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26049588
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.24255850
54IGF1R_20145208_ChIP-Seq_DFB_Human1.23757941
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23510367
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20838977
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19880072
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19525089
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19004368
60REST_21632747_ChIP-Seq_MESCs_Mouse1.18650150
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18597961
62HTT_18923047_ChIP-ChIP_STHdh_Human1.18417539
63NANOG_20526341_ChIP-Seq_ESCs_Human1.17713919
64NCOR_22424771_ChIP-Seq_293T_Human1.15070850
65TTF2_22483619_ChIP-Seq_HELA_Human1.14578026
66SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12091906
67EWS_26573619_Chip-Seq_HEK293_Human1.11112778
68TP53_20018659_ChIP-ChIP_R1E_Mouse1.09779434
69CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07790622
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07536745
71XRN2_22483619_ChIP-Seq_HELA_Human1.07377887
72EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.06883616
73GATA3_21878914_ChIP-Seq_MCF-7_Human1.05195150
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05004694
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05004694
76TAF15_26573619_Chip-Seq_HEK293_Human1.03134899
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01822312
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00447254
79MYC_18358816_ChIP-ChIP_MESCs_Mouse1.00288971
80FLI1_27457419_Chip-Seq_LIVER_Mouse0.99754277
81RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99536887
82TAF2_19829295_ChIP-Seq_ESCs_Human0.99523299
83PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.99426729
84AR_21572438_ChIP-Seq_LNCaP_Human0.99326694
85TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99121404
86ELK1_22589737_ChIP-Seq_MCF10A_Human0.98216549
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98005868
88AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96122959
89NANOG_19829295_ChIP-Seq_ESCs_Human0.95723597
90SOX2_19829295_ChIP-Seq_ESCs_Human0.95723597
91GBX2_23144817_ChIP-Seq_PC3_Human0.95521335
92MYC_19829295_ChIP-Seq_ESCs_Human0.94425013
93P300_19829295_ChIP-Seq_ESCs_Human0.93263561
94FOXA1_25329375_ChIP-Seq_VCAP_Human0.93011210
95FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93011210
96SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92966257
97AR_20517297_ChIP-Seq_VCAP_Human0.92673948
98SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92630987
99EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92366415
100P53_21459846_ChIP-Seq_SAOS-2_Human0.91119911

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.85451000
2MP0002638_abnormal_pupillary_reflex3.50352894
3MP0006292_abnormal_olfactory_placode3.00416250
4MP0003646_muscle_fatigue2.86964845
5MP0005671_abnormal_response_to2.80113903
6MP0004145_abnormal_muscle_electrophysio2.46645520
7MP0002163_abnormal_gland_morphology2.46485299
8MP0002102_abnormal_ear_morphology2.29662253
9MP0005645_abnormal_hypothalamus_physiol2.20092335
10MP0004142_abnormal_muscle_tone2.05987279
11MP0001968_abnormal_touch/_nociception2.01390982
12MP0005646_abnormal_pituitary_gland1.96748492
13MP0002277_abnormal_respiratory_mucosa1.95834965
14MP0002837_dystrophic_cardiac_calcinosis1.93979225
15MP0003011_delayed_dark_adaptation1.93069403
16MP0006072_abnormal_retinal_apoptosis1.80776015
17MP0004885_abnormal_endolymph1.79881488
18MP0003136_yellow_coat_color1.79318452
19MP0002736_abnormal_nociception_after1.75935171
20MP0008995_early_reproductive_senescence1.69368764
21MP0003787_abnormal_imprinting1.64905154
22MP0001905_abnormal_dopamine_level1.59336828
23MP0001986_abnormal_taste_sensitivity1.54582537
24MP0000372_irregular_coat_pigmentation1.54495782
25MP0002876_abnormal_thyroid_physiology1.53323228
26MP0006276_abnormal_autonomic_nervous1.51842194
27MP0008877_abnormal_DNA_methylation1.50663242
28MP0005551_abnormal_eye_electrophysiolog1.50153441
29MP0009745_abnormal_behavioral_response1.48648181
30MP0003786_premature_aging1.47211015
31MP0005379_endocrine/exocrine_gland_phen1.45217550
32MP0002160_abnormal_reproductive_system1.45016027
33MP0003880_abnormal_central_pattern1.43007737
34MP0002938_white_spotting1.41736481
35MP0002095_abnormal_skin_pigmentation1.40804701
36MP0001485_abnormal_pinna_reflex1.40255892
37MP0008789_abnormal_olfactory_epithelium1.39418101
38MP0000049_abnormal_middle_ear1.37258639
39MP0008875_abnormal_xenobiotic_pharmacok1.36784610
40MP0002272_abnormal_nervous_system1.35467941
41MP0008872_abnormal_physiological_respon1.35349259
42MP0000631_abnormal_neuroendocrine_gland1.33006476
43MP0009333_abnormal_splenocyte_physiolog1.32593928
44MP0005389_reproductive_system_phenotype1.32539895
45MP0004742_abnormal_vestibular_system1.31814307
46MP0005377_hearing/vestibular/ear_phenot1.27628841
47MP0003878_abnormal_ear_physiology1.27628841
48MP0005253_abnormal_eye_physiology1.24387868
49MP0009046_muscle_twitch1.23515003
50MP0010386_abnormal_urinary_bladder1.18896112
51MP0003122_maternal_imprinting1.18595878
52MP0005084_abnormal_gallbladder_morpholo1.17384618
53MP0001919_abnormal_reproductive_system1.10730854
54MP0001529_abnormal_vocalization1.03134809
55MP0000026_abnormal_inner_ear1.02957003
56MP0003123_paternal_imprinting0.98459899
57MP0005423_abnormal_somatic_nervous0.97772421
58MP0001970_abnormal_pain_threshold0.97625112
59MP0000778_abnormal_nervous_system0.96972055
60MP0005083_abnormal_biliary_tract0.96827326
61MP0001188_hyperpigmentation0.96702105
62MP0003195_calcinosis0.96192158
63MP0003879_abnormal_hair_cell0.94966710
64MP0005499_abnormal_olfactory_system0.93998958
65MP0005394_taste/olfaction_phenotype0.93998958
66MP0002733_abnormal_thermal_nociception0.93398908
67MP0002735_abnormal_chemical_nociception0.92896968
68MP0001440_abnormal_grooming_behavior0.90563745
69MP0002752_abnormal_somatic_nervous0.87619412
70MP0003121_genomic_imprinting0.87321723
71MP0003938_abnormal_ear_development0.87211958
72MP0002653_abnormal_ependyma_morphology0.86404866
73MP0005387_immune_system_phenotype0.85884700
74MP0001790_abnormal_immune_system0.85884700
75MP0002557_abnormal_social/conspecific_i0.85407526
76MP0001963_abnormal_hearing_physiology0.82268250
77MP0002184_abnormal_innervation0.81981655
78MP0001800_abnormal_humoral_immune0.78889553
79MP0002064_seizures0.77869837
80MP0002822_catalepsy0.77350317
81MP0005195_abnormal_posterior_eye0.77054976
82MP0002909_abnormal_adrenal_gland0.76888513
83MP0009250_abnormal_appendicular_skeleto0.76653598
84MP0009785_altered_susceptibility_to0.76438448
85MP0001486_abnormal_startle_reflex0.76240026
86MP0002210_abnormal_sex_determination0.72885614
87MP0006036_abnormal_mitochondrial_physio0.72311139
88MP0002572_abnormal_emotion/affect_behav0.72252713
89MP0003635_abnormal_synaptic_transmissio0.71778040
90MP0002734_abnormal_mechanical_nocicepti0.69553557
91MP0002067_abnormal_sensory_capabilities0.68808091
92MP0004133_heterotaxia0.67529178
93MP0003567_abnormal_fetal_cardiomyocyte0.66749463
94MP0001542_abnormal_bone_strength0.66685306
95MP0003186_abnormal_redox_activity0.66594148
96MP0005085_abnormal_gallbladder_physiolo0.65828091
97MP0003763_abnormal_thymus_physiology0.65693880
98MP0003806_abnormal_nucleotide_metabolis0.65421417
99MP0003137_abnormal_impulse_conducting0.64925643
100MP0002138_abnormal_hepatobiliary_system0.64409042

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.35967703
2Acute necrotizing encephalopathy (HP:0006965)5.17890538
3Abnormal mitochondria in muscle tissue (HP:0008316)4.71038427
4Mitochondrial inheritance (HP:0001427)4.64077048
5Abnormality of cells of the erythroid lineage (HP:0012130)4.58786215
6Progressive macrocephaly (HP:0004481)4.29927627
7Acute encephalopathy (HP:0006846)4.19596776
8Lipid accumulation in hepatocytes (HP:0006561)4.11937967
9Increased hepatocellular lipid droplets (HP:0006565)4.01386157
10Increased CSF lactate (HP:0002490)4.00360027
11Macrocytic anemia (HP:0001972)3.96194195
12Abnormal number of erythroid precursors (HP:0012131)3.90347087
13Hepatocellular necrosis (HP:0001404)3.71918681
14Congenital stationary night blindness (HP:0007642)3.67776089
153-Methylglutaconic aciduria (HP:0003535)3.58515041
16Pallor (HP:0000980)3.57132959
17Aplastic anemia (HP:0001915)3.54469622
18Renal Fanconi syndrome (HP:0001994)3.52901108
19Hepatic necrosis (HP:0002605)3.35808260
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.29321335
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.29321335
22Stenosis of the external auditory canal (HP:0000402)3.17546996
23Increased intramyocellular lipid droplets (HP:0012240)3.16352934
24Cerebral edema (HP:0002181)3.09692784
25Increased muscle lipid content (HP:0009058)2.96828156
26Exertional dyspnea (HP:0002875)2.79383613
27Optic disc pallor (HP:0000543)2.78388321
28Absent thumb (HP:0009777)2.53587923
29Abnormality of the renal collecting system (HP:0004742)2.50576067
30Absent rod-and cone-mediated responses on ERG (HP:0007688)2.50417708
31Molar tooth sign on MRI (HP:0002419)2.48995528
32Abnormality of midbrain morphology (HP:0002418)2.48995528
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.48499229
34Colon cancer (HP:0003003)2.44586906
35Respiratory failure (HP:0002878)2.40491940
36Abnormality of renal resorption (HP:0011038)2.38324031
37Septo-optic dysplasia (HP:0100842)2.33432937
38Methylmalonic aciduria (HP:0012120)2.32261039
39Abnormal rod and cone electroretinograms (HP:0008323)2.32214143
40Increased serum lactate (HP:0002151)2.31643640
41Lactic acidosis (HP:0003128)2.31218357
42Respiratory difficulties (HP:0002880)2.29306256
43Methylmalonic acidemia (HP:0002912)2.28933500
44IgG deficiency (HP:0004315)2.25491573
45Pancreatic cysts (HP:0001737)2.22478999
46Congenital, generalized hypertrichosis (HP:0004540)2.22015591
47Pancreatic fibrosis (HP:0100732)2.19702891
48Type 2 muscle fiber atrophy (HP:0003554)2.18927699
49Myokymia (HP:0002411)2.17183265
50Exercise intolerance (HP:0003546)2.16759657
51Abnormality of DNA repair (HP:0003254)2.11919829
52Lethargy (HP:0001254)2.11014741
53Glycosuria (HP:0003076)2.10326509
54Abnormality of urine glucose concentration (HP:0011016)2.10326509
55Leukodystrophy (HP:0002415)2.09273796
56Pendular nystagmus (HP:0012043)2.06835266
57Aplasia/Hypoplasia of the sacrum (HP:0008517)2.06543795
58Oral leukoplakia (HP:0002745)2.06422010
59Increased IgM level (HP:0003496)2.04934491
60Palpebral edema (HP:0100540)2.02999206
61Hyperphosphaturia (HP:0003109)2.01525466
62Hyperglycinemia (HP:0002154)1.95097756
63True hermaphroditism (HP:0010459)1.94974575
64Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.94043089
65Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.89175666
66Muscle fiber atrophy (HP:0100295)1.89098787
67Polydipsia (HP:0001959)1.82275300
68Abnormal drinking behavior (HP:0030082)1.82275300
69Pancytopenia (HP:0001876)1.81453885
70Asplenia (HP:0001746)1.80883607
71Abnormal hemoglobin (HP:0011902)1.78668019
72Aplasia/Hypoplasia of the spleen (HP:0010451)1.76363678
73Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76022485
74Sclerocornea (HP:0000647)1.75735092
75Generalized aminoaciduria (HP:0002909)1.75496394
76Hypoplasia of the radius (HP:0002984)1.75348827
77Partial duplication of the phalanx of hand (HP:0009999)1.74859779
78Absent phalangeal crease (HP:0006109)1.74436893
79Maternal diabetes (HP:0009800)1.73308462
80Depressed nasal ridge (HP:0000457)1.73033843
81Abnormality of magnesium homeostasis (HP:0004921)1.71038321
82Duplicated collecting system (HP:0000081)1.70120111
83Medial flaring of the eyebrow (HP:0010747)1.69982812
84Abnormality of the phalanges of the 2nd finger (HP:0009541)1.68428479
85Abnormal respiratory motile cilium physiology (HP:0012261)1.66682569
86X-linked dominant inheritance (HP:0001423)1.62296160
87Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.62207356
88Abolished electroretinogram (ERG) (HP:0000550)1.62165717
89Decreased central vision (HP:0007663)1.62105167
90Abnormal urine phosphate concentration (HP:0012599)1.61722894
91Symphalangism affecting the phalanges of the hand (HP:0009773)1.61625227
92Abnormality of alanine metabolism (HP:0010916)1.61560774
93Hyperalaninemia (HP:0003348)1.61560774
94Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.61560774
95Nephronophthisis (HP:0000090)1.60933064
96CNS demyelination (HP:0007305)1.60179422
97Anencephaly (HP:0002323)1.59658484
98Dicarboxylic aciduria (HP:0003215)1.59210495
99Abnormality of dicarboxylic acid metabolism (HP:0010995)1.59210495
100Abnormality of the phalanges of the 5th finger (HP:0004213)1.58946833

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.20304327
2STK163.57823834
3ADRBK22.77686411
4TAOK32.75733107
5WNK42.66421520
6TESK22.59956838
7BCKDK2.57558138
8VRK22.54386871
9TLK12.43352782
10KDR2.34782865
11GRK12.24574449
12TIE11.94253228
13ZAK1.93948449
14DYRK21.87521518
15VRK11.85713301
16MAP4K21.80461389
17MAP4K11.76950178
18NUAK11.55936121
19PDK21.53206595
20MAPK131.51535660
21MUSK1.47244626
22STK391.47123892
23OBSCN1.46096067
24PINK11.42505699
25LIMK11.31799212
26PASK1.31751579
27WNK31.26728166
28PHKG21.26374605
29PHKG11.26374605
30MAP2K61.25322868
31NME21.11584519
32NME11.10864086
33TEC1.09521546
34ADRBK11.06549889
35AURKA1.06298722
36FRK1.04542937
37CDK191.03710839
38INSRR1.02635702
39RPS6KA50.96734012
40ITK0.96695922
41MARK10.95164894
42MST40.93980483
43DAPK30.92682328
44PRKCQ0.91607310
45GRK70.89951046
46LRRK20.88745472
47OXSR10.88604045
48MAP3K110.84740802
49ABL20.83320583
50PIK3CA0.80408173
51SYK0.79087197
52BUB10.79061629
53IKBKE0.75011937
54MAP3K120.71046678
55SIK20.70987612
56PRKACA0.69505090
57MINK10.68720764
58PRKCG0.67551341
59EPHB20.66447200
60NTRK20.65326071
61CSNK2A20.62210481
62PRKCH0.61404631
63PKN10.58908345
64IKBKB0.57204193
65MAP2K70.57034006
66LCK0.56899361
67WNK10.55174114
68CSNK2A10.54786841
69PIM20.54733067
70BMPR1B0.54407118
71MAPK150.54380660
72NTRK30.53995457
73CSNK1G20.53754629
74TYRO30.53734395
75ILK0.53077514
76PRKCA0.49805446
77GRK50.48891075
78NEK10.48636289
79CHEK20.48201601
80CASK0.47998441
81TAF10.47813830
82CAMK2A0.47694205
83CSNK1G30.46419690
84MAP2K20.46166094
85CDC70.44540911
86PIM10.44249398
87TAOK20.42847310
88PRKCD0.42705698
89STK110.42055069
90PRKG10.41557718
91CAMK10.40822635
92LYN0.40721725
93PLK40.40645897
94BTK0.40435296
95DAPK20.39937316
96AURKB0.39588382
97CCNB10.39006736
98CSNK1A10.38576227
99CSNK1G10.37879786
100CAMK2G0.35864465

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.57636233
2Oxidative phosphorylation_Homo sapiens_hsa001904.75929966
3Parkinsons disease_Homo sapiens_hsa050124.07360869
4Alzheimers disease_Homo sapiens_hsa050102.85333540
5Proteasome_Homo sapiens_hsa030502.79117522
6Huntingtons disease_Homo sapiens_hsa050162.67239742
7Cardiac muscle contraction_Homo sapiens_hsa042602.65286582
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.49760707
9Primary immunodeficiency_Homo sapiens_hsa053402.30526196
10RNA polymerase_Homo sapiens_hsa030202.06201666
11Phototransduction_Homo sapiens_hsa047441.74327077
12Protein export_Homo sapiens_hsa030601.73584843
13Systemic lupus erythematosus_Homo sapiens_hsa053221.67711580
14Allograft rejection_Homo sapiens_hsa053301.66404347
15Autoimmune thyroid disease_Homo sapiens_hsa053201.66168027
16Graft-versus-host disease_Homo sapiens_hsa053321.56657950
17Linoleic acid metabolism_Homo sapiens_hsa005911.56479540
18Sulfur relay system_Homo sapiens_hsa041221.45749412
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42858207
20Type I diabetes mellitus_Homo sapiens_hsa049401.40760400
21Asthma_Homo sapiens_hsa053101.38096576
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37269051
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34355019
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31347765
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.21813956
26Homologous recombination_Homo sapiens_hsa034401.19634731
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.11198999
28Nicotine addiction_Homo sapiens_hsa050331.11023899
29Basal transcription factors_Homo sapiens_hsa030221.08306586
30Pyrimidine metabolism_Homo sapiens_hsa002401.03277106
31Olfactory transduction_Homo sapiens_hsa047401.02534435
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00743810
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99514974
34RNA degradation_Homo sapiens_hsa030180.90942424
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90294534
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89582084
37Antigen processing and presentation_Homo sapiens_hsa046120.89011316
38Alcoholism_Homo sapiens_hsa050340.88182187
39Nitrogen metabolism_Homo sapiens_hsa009100.84816411
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84253766
41Butanoate metabolism_Homo sapiens_hsa006500.83993613
42Chemical carcinogenesis_Homo sapiens_hsa052040.82846249
43Purine metabolism_Homo sapiens_hsa002300.82440955
44Nucleotide excision repair_Homo sapiens_hsa034200.80288237
45Caffeine metabolism_Homo sapiens_hsa002320.79480030
46Rheumatoid arthritis_Homo sapiens_hsa053230.79166178
47Hematopoietic cell lineage_Homo sapiens_hsa046400.78241075
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76669785
49Fanconi anemia pathway_Homo sapiens_hsa034600.76084994
50Morphine addiction_Homo sapiens_hsa050320.75277803
51Spliceosome_Homo sapiens_hsa030400.74440819
52Retinol metabolism_Homo sapiens_hsa008300.73196947
53Peroxisome_Homo sapiens_hsa041460.72717309
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.72366861
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71512393
56Viral myocarditis_Homo sapiens_hsa054160.70183872
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.68525422
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68101287
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67896898
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67480105
61DNA replication_Homo sapiens_hsa030300.67467928
62One carbon pool by folate_Homo sapiens_hsa006700.66272150
63Arachidonic acid metabolism_Homo sapiens_hsa005900.63987623
64Mismatch repair_Homo sapiens_hsa034300.63529502
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60337412
66GABAergic synapse_Homo sapiens_hsa047270.58450651
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56956462
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56866252
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55526839
70Sulfur metabolism_Homo sapiens_hsa009200.55252515
71Ether lipid metabolism_Homo sapiens_hsa005650.54632870
72Metabolic pathways_Homo sapiens_hsa011000.54552689
73Collecting duct acid secretion_Homo sapiens_hsa049660.53802606
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53606577
75Propanoate metabolism_Homo sapiens_hsa006400.53403827
76Fat digestion and absorption_Homo sapiens_hsa049750.51439116
77Tryptophan metabolism_Homo sapiens_hsa003800.50871424
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50552135
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47195534
80Taste transduction_Homo sapiens_hsa047420.44936153
81Regulation of autophagy_Homo sapiens_hsa041400.42484874
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42152974
83Circadian entrainment_Homo sapiens_hsa047130.41786098
84T cell receptor signaling pathway_Homo sapiens_hsa046600.40286785
85Base excision repair_Homo sapiens_hsa034100.38395305
86Pyruvate metabolism_Homo sapiens_hsa006200.38252533
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.36597576
88Serotonergic synapse_Homo sapiens_hsa047260.35386193
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.34219243
90RNA transport_Homo sapiens_hsa030130.30528368
91Hedgehog signaling pathway_Homo sapiens_hsa043400.28727199
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27210954
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25716501
94Insulin secretion_Homo sapiens_hsa049110.25389336
95Malaria_Homo sapiens_hsa051440.25334595
96Folate biosynthesis_Homo sapiens_hsa007900.23645247
97Glutamatergic synapse_Homo sapiens_hsa047240.22897426
98Cholinergic synapse_Homo sapiens_hsa047250.22833448
99Glutathione metabolism_Homo sapiens_hsa004800.21684981
100Calcium signaling pathway_Homo sapiens_hsa040200.18825934

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