ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	7.88609724
2	translational termination (GO:0006415)	7.52455225
3	ribosomal small subunit assembly (GO:0000028)	6.95598326
4	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.69190122
5	translational elongation (GO:0006414)	6.66245174
6	cotranslational protein targeting to membrane (GO:0006613)	6.54629872
7	protein targeting to ER (GO:0045047)	6.52866481
8	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.23714447
9	protein localization to endoplasmic reticulum (GO:0070972)	6.19069715
10	maturation of SSU-rRNA (GO:0030490)	6.00527157
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.99912762
12	ATP synthesis coupled proton transport (GO:0015986)	5.99912762
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.92862609
14	cellular protein complex disassembly (GO:0043624)	5.71081428
15	ribosomal small subunit biogenesis (GO:0042274)	5.56676241
16	viral life cycle (GO:0019058)	5.54603264
17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.49547080
18	translational initiation (GO:0006413)	5.00098882
19	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.90460859
20	protein complex disassembly (GO:0043241)	4.76267098
21	respiratory electron transport chain (GO:0022904)	4.57458953
22	translation (GO:0006412)	4.52891669
23	electron transport chain (GO:0022900)	4.49770280
24	DNA deamination (GO:0045006)	4.48291550
25	macromolecular complex disassembly (GO:0032984)	4.45067034
26	protein neddylation (GO:0045116)	4.44847053
27	nucleotide salvage (GO:0043173)	4.44601235
28	protein targeting to membrane (GO:0006612)	4.40785091
29	protein complex biogenesis (GO:0070271)	4.34470298
30	ribosomal large subunit biogenesis (GO:0042273)	4.23762627
31	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.12641509
32	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.12641509
33	mitochondrial respiratory chain complex assembly (GO:0033108)	4.10913523
34	cytidine deamination (GO:0009972)	3.98623117
35	cytidine metabolic process (GO:0046087)	3.98623117
36	cytidine catabolic process (GO:0006216)	3.98623117
37	purine nucleotide salvage (GO:0032261)	3.94424681
38	regulation of activation of Janus kinase activity (GO:0010533)	3.79362364
39	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.79174141
40	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.77328298
41	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.77187296
42	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.77187296
43	NADH dehydrogenase complex assembly (GO:0010257)	3.77187296
44	CTP metabolic process (GO:0046036)	3.72743297
45	CTP biosynthetic process (GO:0006241)	3.72743297
46	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.64529268
47	nucleoside salvage (GO:0043174)	3.59548378
48	mRNA catabolic process (GO:0006402)	3.52902670
49	ATP biosynthetic process (GO:0006754)	3.51799044
50	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.43295334
51	hydrogen ion transmembrane transport (GO:1902600)	3.36675601
52	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.35830223
53	chaperone-mediated protein transport (GO:0072321)	3.29457564
54	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.27610638
55	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.27020245
56	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	3.26770095
57	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.25343057
58	RNA catabolic process (GO:0006401)	3.23392623
59	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	3.21176861
60	UMP biosynthetic process (GO:0006222)	3.21176861
61	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	3.21176861
62	UMP metabolic process (GO:0046049)	3.21176861
63	cellular component biogenesis (GO:0044085)	3.14633857
64	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.13948548
65	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.12881663
66	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.12694960
67	purine-containing compound salvage (GO:0043101)	3.09937611
68	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	3.06610946
69	proteasome assembly (GO:0043248)	3.03882108
70	ribonucleoprotein complex biogenesis (GO:0022613)	2.99089631
71	proton transport (GO:0015992)	2.98413454
72	behavioral response to nicotine (GO:0035095)	2.91957440
73	establishment of protein localization to membrane (GO:0090150)	2.91804270
74	hydrogen transport (GO:0006818)	2.91176876
75	nucleoside triphosphate biosynthetic process (GO:0009142)	2.89607545
76	GTP biosynthetic process (GO:0006183)	2.85262289
77	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.84178517
78	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.78945619
79	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.74771640
80	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.73288666
81	positive T cell selection (GO:0043368)	2.72233694
82	GPI anchor metabolic process (GO:0006505)	2.68971889
83	cytochrome complex assembly (GO:0017004)	2.68026069
84	cytolysis (GO:0019835)	2.66856113
85	protein targeting (GO:0006605)	2.66738096
86	pyrimidine-containing compound salvage (GO:0008655)	2.66283824
87	pyrimidine nucleoside salvage (GO:0043097)	2.66283824
88	negative regulation of heart rate (GO:0010459)	2.65501025
89	negative regulation of T cell apoptotic process (GO:0070233)	2.65405408
90	S-adenosylmethionine metabolic process (GO:0046500)	2.64330614
91	respiratory chain complex IV assembly (GO:0008535)	2.63080963
92	positive regulation of calcium-mediated signaling (GO:0050850)	2.61884700
93	GPI anchor biosynthetic process (GO:0006506)	2.61828099
94	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	2.60243374
95	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.55874666
96	platelet dense granule organization (GO:0060155)	2.53417086
97	cellular ketone body metabolic process (GO:0046950)	2.50896701
98	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.49918716
99	regulation of chronic inflammatory response (GO:0002676)	2.48871887
100	regulation of T cell tolerance induction (GO:0002664)	2.48372326

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.04031847
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.70731217
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.60733104
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.35200899
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.22587932
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.02483400
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.68589559
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.58237318
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.51805256
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.48200964
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.41295701
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.33826508
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.23170831
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.19546863
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.17456294
16	VDR_22108803_ChIP-Seq_LS180_Human	2.16324336
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.04184093
18	ELK1_19687146_ChIP-ChIP_HELA_Human	1.89918111
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.80666537
20	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.79038543
21	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.74386598
22	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.72397493
23	FOXP3_21729870_ChIP-Seq_TREG_Human	1.69869934
24	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.69581073
25	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.67455199
26	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.63569795
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.57449578
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.52355978
29	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.50934128
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.50397655
31	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.48799654
32	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.42446488
33	ZNF274_21170338_ChIP-Seq_K562_Hela	1.39952874
34	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.38914733
35	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.37745503
36	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.35407088
37	IGF1R_20145208_ChIP-Seq_DFB_Human	1.34433029
38	TTF2_22483619_ChIP-Seq_HELA_Human	1.32011557
39	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.30945976
40	NCOR_22424771_ChIP-Seq_293T_Human	1.29245714
41	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.29200585
42	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.27971831
43	NANOG_20526341_ChIP-Seq_ESCs_Human	1.24765921
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.24558044
45	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.23466885
46	GATA3_26560356_Chip-Seq_TH2_Human	1.22388459
47	TAF15_26573619_Chip-Seq_HEK293_Human	1.21303129
48	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.21282953
49	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.20952000
50	EWS_26573619_Chip-Seq_HEK293_Human	1.20190584
51	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.19525923
52	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.18316848
53	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.18304422
54	FUS_26573619_Chip-Seq_HEK293_Human	1.18058853
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16729848
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16729848
57	TAF2_19829295_ChIP-Seq_ESCs_Human	1.16486346
58	ERA_21632823_ChIP-Seq_H3396_Human	1.15571925
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15254234
60	AR_20517297_ChIP-Seq_VCAP_Human	1.13968667
61	HTT_18923047_ChIP-ChIP_STHdh_Human	1.13073305
62	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.11613728
63	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.11000160
64	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.09716836
65	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.09155576
66	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.09063594
67	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.09007779
68	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.06549806
69	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.04203267
70	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.02549839
71	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.02413665
72	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.01691631
73	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.99940333
74	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.99728870
75	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99651163
76	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.99029385
77	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.98483206
78	P53_21459846_ChIP-Seq_SAOS-2_Human	0.98443032
79	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.98122487
80	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.96847020
81	CTCF_20526341_ChIP-Seq_ESCs_Human	0.96746668
82	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.95613419
83	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.94878794
84	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.94867508
85	RNF2_27304074_Chip-Seq_NSC_Mouse	0.94455746
86	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.94376384
87	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.94231752
88	RUNX_20019798_ChIP-Seq_JUKART_Human	0.93901365
89	MYB_26560356_Chip-Seq_TH2_Human	0.93421756
90	P300_19829295_ChIP-Seq_ESCs_Human	0.92779420
91	BCL6_27268052_Chip-Seq_Bcells_Human	0.91039469
92	NANOG_19829295_ChIP-Seq_ESCs_Human	0.90388972
93	SOX2_19829295_ChIP-Seq_ESCs_Human	0.90388972
94	CBP_20019798_ChIP-Seq_JUKART_Human	0.89495633
95	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.89495633
96	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.89343311
97	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.89153102
98	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.88858659
99	BCAT_22108803_ChIP-Seq_LS180_Human	0.88817915
100	ERG_20517297_ChIP-Seq_VCAP_Human	0.88742347

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.60983027
2	MP0005671_abnormal_response_to	4.11365553
3	MP0002163_abnormal_gland_morphology	3.33108002
4	MP0001835_abnormal_antigen_presentation	3.13962970
5	MP0006292_abnormal_olfactory_placode	2.97318328
6	MP0001188_hyperpigmentation	2.78202830
7	MP0003646_muscle_fatigue	2.40010847
8	MP0004147_increased_porphyrin_level	2.26201079
9	MP0000372_irregular_coat_pigmentation	2.16426126
10	MP0004885_abnormal_endolymph	2.14407639
11	MP0005379_endocrine/exocrine_gland_phen	2.08040689
12	MP0002837_dystrophic_cardiac_calcinosis	1.95202357
13	MP0009785_altered_susceptibility_to	1.89930471
14	MP0008872_abnormal_physiological_respon	1.88621670
15	MP0008875_abnormal_xenobiotic_pharmacok	1.72464377
16	MP0002234_abnormal_pharynx_morphology	1.69598639
17	MP0002148_abnormal_hypersensitivity_rea	1.65009651
18	MP0006072_abnormal_retinal_apoptosis	1.57242328
19	MP0001905_abnormal_dopamine_level	1.56163566
20	MP0005075_abnormal_melanosome_morpholog	1.51515896
21	MP0003763_abnormal_thymus_physiology	1.50694211
22	MP0005000_abnormal_immune_tolerance	1.48428542
23	MP0005551_abnormal_eye_electrophysiolog	1.46210328
24	MP0002166_altered_tumor_susceptibility	1.46186610
25	MP0005645_abnormal_hypothalamus_physiol	1.46018835
26	MP0004142_abnormal_muscle_tone	1.45221716
27	MP0005389_reproductive_system_phenotype	1.45017313
28	MP0001968_abnormal_touch/_nociception	1.43977761
29	MP0001800_abnormal_humoral_immune	1.43920422
30	MP0002277_abnormal_respiratory_mucosa	1.43684124
31	MP0003880_abnormal_central_pattern	1.43595844
32	MP0009333_abnormal_splenocyte_physiolog	1.43069277
33	MP0010386_abnormal_urinary_bladder	1.41829024
34	MP0001348_abnormal_lacrimal_gland	1.41511900
35	MP0002736_abnormal_nociception_after	1.40884643
36	MP0001919_abnormal_reproductive_system	1.40164983
37	MP0003011_delayed_dark_adaptation	1.40014158
38	MP0002160_abnormal_reproductive_system	1.36556966
39	MP0003806_abnormal_nucleotide_metabolis	1.34393290
40	MP0005084_abnormal_gallbladder_morpholo	1.32576452
41	MP0003724_increased_susceptibility_to	1.30887284
42	MP0003195_calcinosis	1.30739269
43	MP0001529_abnormal_vocalization	1.25998399
44	MP0004145_abnormal_muscle_electrophysio	1.25874220
45	MP0002095_abnormal_skin_pigmentation	1.24251630
46	MP0001873_stomach_inflammation	1.23586987
47	MP0006082_CNS_inflammation	1.23174790
48	MP0005387_immune_system_phenotype	1.21821124
49	MP0001790_abnormal_immune_system	1.21821124
50	MP0002723_abnormal_immune_serum	1.20064258
51	MP0005253_abnormal_eye_physiology	1.19514965
52	MP0005646_abnormal_pituitary_gland	1.15994581
53	MP0002420_abnormal_adaptive_immunity	1.12775539
54	MP0002006_tumorigenesis	1.12079159
55	MP0005025_abnormal_response_to	1.11640563
56	MP0001819_abnormal_immune_cell	1.11452984
57	MP0002102_abnormal_ear_morphology	1.09329848
58	MP0003878_abnormal_ear_physiology	1.07220523
59	MP0005377_hearing/vestibular/ear_phenot	1.07220523
60	MP0000049_abnormal_middle_ear	1.06619712
61	MP0002452_abnormal_antigen_presenting	1.06543994
62	MP0003866_abnormal_defecation	1.06346644
63	MP0003136_yellow_coat_color	1.05902158
64	MP0000685_abnormal_immune_system	1.03264012
65	MP0005503_abnormal_tendon_morphology	1.02069217
66	MP0005410_abnormal_fertilization	1.00918982
67	MP0003186_abnormal_redox_activity	1.00569775
68	MP0008789_abnormal_olfactory_epithelium	0.98333377
69	MP0001485_abnormal_pinna_reflex	0.97627040
70	MP0002272_abnormal_nervous_system	0.93192600
71	MP0000538_abnormal_urinary_bladder	0.91148045
72	MP0006276_abnormal_autonomic_nervous	0.90975650
73	MP0009745_abnormal_behavioral_response	0.89161265
74	MP0010155_abnormal_intestine_physiology	0.89033403
75	MP0001984_abnormal_olfaction	0.88974666
76	MP0000716_abnormal_immune_system	0.87788355
77	MP0008877_abnormal_DNA_methylation	0.86498622
78	MP0002822_catalepsy	0.86435623
79	MP0005174_abnormal_tail_pigmentation	0.85434858
80	MP0005360_urolithiasis	0.84162537
81	MP0009764_decreased_sensitivity_to	0.81022815
82	MP0002398_abnormal_bone_marrow	0.80457596
83	MP0001970_abnormal_pain_threshold	0.78616192
84	MP0003567_abnormal_fetal_cardiomyocyte	0.78274853
85	MP0000631_abnormal_neuroendocrine_gland	0.77540219
86	MP0001845_abnormal_inflammatory_respons	0.76664808
87	MP0002938_white_spotting	0.76497134
88	MP0000678_abnormal_parathyroid_gland	0.74924118
89	MP0002638_abnormal_pupillary_reflex	0.73649571
90	MP0002933_joint_inflammation	0.73343912
91	MP0005636_abnormal_mineral_homeostasis	0.73286560
92	MP0003786_premature_aging	0.73140469
93	MP0001764_abnormal_homeostasis	0.72789753
94	MP0000703_abnormal_thymus_morphology	0.71822133
95	MP0005332_abnormal_amino_acid	0.70224961
96	MP0001664_abnormal_digestion	0.69722329
97	MP0001963_abnormal_hearing_physiology	0.69591829
98	MP0004742_abnormal_vestibular_system	0.66076065
99	MP0003787_abnormal_imprinting	0.65274990
100	MP0002405_respiratory_system_inflammati	0.61728339

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.24961766
2	Mitochondrial inheritance (HP:0001427)	4.92877199
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.88708451
4	Acute encephalopathy (HP:0006846)	4.47099828
5	Increased hepatocellular lipid droplets (HP:0006565)	4.36038994
6	Progressive macrocephaly (HP:0004481)	4.35294564
7	Increased CSF lactate (HP:0002490)	4.15943130
8	Lipid accumulation in hepatocytes (HP:0006561)	3.98085407
9	Increased intramyocellular lipid droplets (HP:0012240)	3.95033017
10	Hepatocellular necrosis (HP:0001404)	3.90031355
11	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.81234109
12	Renal Fanconi syndrome (HP:0001994)	3.66799002
13	Macrocytic anemia (HP:0001972)	3.63495615
14	3-Methylglutaconic aciduria (HP:0003535)	3.60105850
15	Abnormality of cells of the erythroid lineage (HP:0012130)	3.51965279
16	Hepatic necrosis (HP:0002605)	3.42799672
17	Exertional dyspnea (HP:0002875)	3.32650229
18	Cerebral edema (HP:0002181)	3.32209401
19	Reticulocytopenia (HP:0001896)	3.32094868
20	Increased muscle lipid content (HP:0009058)	3.30859641
21	Hypoplasia of the pons (HP:0012110)	3.23636102
22	Abnormality of the pons (HP:0007361)	3.18649953
23	Abnormal number of erythroid precursors (HP:0012131)	3.14444631
24	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.07738649
25	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.07738649
26	Decreased central vision (HP:0007663)	3.05596552
27	Elevated erythrocyte sedimentation rate (HP:0003565)	2.98553834
28	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.96938907
29	Abnormal rod and cone electroretinograms (HP:0008323)	2.92332550
30	Optic disc pallor (HP:0000543)	2.90873151
31	IgG deficiency (HP:0004315)	2.89960309
32	Congenital, generalized hypertrichosis (HP:0004540)	2.88348003
33	Pallor (HP:0000980)	2.85123859
34	Congenital stationary night blindness (HP:0007642)	2.79916135
35	Methylmalonic acidemia (HP:0002912)	2.76009697
36	Aplastic anemia (HP:0001915)	2.75234928
37	Abnormal hemoglobin (HP:0011902)	2.72596160
38	Hypoproteinemia (HP:0003075)	2.59967873
39	Severe combined immunodeficiency (HP:0004430)	2.55341856
40	Respiratory difficulties (HP:0002880)	2.54055993
41	Abnormality of midbrain morphology (HP:0002418)	2.47674637
42	Molar tooth sign on MRI (HP:0002419)	2.47674637
43	Pancreatic cysts (HP:0001737)	2.40632388
44	Type II lissencephaly (HP:0007260)	2.37958799
45	Hyperglycinemia (HP:0002154)	2.34174788
46	Leukodystrophy (HP:0002415)	2.34054688
47	Absent/shortened dynein arms (HP:0200106)	2.33348847
48	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.33348847
49	Increased serum lactate (HP:0002151)	2.32577625
50	Abnormality of renal resorption (HP:0011038)	2.32392930
51	Lactic acidosis (HP:0003128)	2.29203551
52	Attenuation of retinal blood vessels (HP:0007843)	2.28233989
53	Respiratory failure (HP:0002878)	2.24124578
54	Stomatitis (HP:0010280)	2.21411767
55	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.18274048
56	Exercise intolerance (HP:0003546)	2.18060993
57	Parakeratosis (HP:0001036)	2.07329401
58	Thyroiditis (HP:0100646)	2.05535680
59	Hyperphosphaturia (HP:0003109)	2.05458361
60	T lymphocytopenia (HP:0005403)	2.05454504
61	Lethargy (HP:0001254)	2.01948999
62	Increased IgM level (HP:0003496)	2.00219318
63	Concave nail (HP:0001598)	1.99133812
64	Abnormality of urine glucose concentration (HP:0011016)	1.98614061
65	Glycosuria (HP:0003076)	1.98614061
66	Methylmalonic aciduria (HP:0012120)	1.98334301
67	Abolished electroretinogram (ERG) (HP:0000550)	1.96600967
68	Abnormality of T cell number (HP:0011839)	1.96181912
69	Autoimmune hemolytic anemia (HP:0001890)	1.95436691
70	Abnormal respiratory motile cilium physiology (HP:0012261)	1.95362080
71	Autoimmune thrombocytopenia (HP:0001973)	1.95074287
72	Pancreatic fibrosis (HP:0100732)	1.93820834
73	Abnormality of eosinophils (HP:0001879)	1.92773228
74	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.90865261
75	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.89806647
76	Abnormality of T cells (HP:0002843)	1.88958896
77	Cerebellar dysplasia (HP:0007033)	1.88572237
78	Asplenia (HP:0001746)	1.87015253
79	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.85764314
80	Cerebral palsy (HP:0100021)	1.83620690
81	Abnormal respiratory motile cilium morphology (HP:0005938)	1.83304053
82	Abnormal respiratory epithelium morphology (HP:0012253)	1.83304053
83	Chronic sinusitis (HP:0011109)	1.82676344
84	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.81462287
85	Absent thumb (HP:0009777)	1.79820606
86	Renal cortical cysts (HP:0000803)	1.79258807
87	Combined immunodeficiency (HP:0005387)	1.78928354
88	Abnormal ciliary motility (HP:0012262)	1.78469761
89	Generalized aminoaciduria (HP:0002909)	1.76426857
90	Abnormality of DNA repair (HP:0003254)	1.75640308
91	Testicular atrophy (HP:0000029)	1.73990909
92	Type I transferrin isoform profile (HP:0003642)	1.73253268
93	Partial duplication of thumb phalanx (HP:0009944)	1.73070545
94	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.73046694
95	Dicarboxylic aciduria (HP:0003215)	1.73046694
96	CNS demyelination (HP:0007305)	1.72563405
97	Supernumerary spleens (HP:0009799)	1.72146778
98	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.71739519
99	True hermaphroditism (HP:0010459)	1.71167351
100	B lymphocytopenia (HP:0010976)	1.70062298

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	KDR	3.75159175
2	LIMK1	3.65863895
3	TAOK3	3.14936676
4	MAP4K1	2.94751149
5	TXK	2.81393098
6	ADRBK2	2.59948205
7	ZAK	2.53580168
8	SCYL2	2.44317085
9	TLK1	2.32160541
10	TESK2	2.11590010
11	VRK2	2.04663763
12	TESK1	2.03373722
13	GRK1	2.02439706
14	BCKDK	2.02383126
15	TIE1	2.02325420
16	MAP4K2	1.88208177
17	BUB1	1.79427226
18	MAP3K12	1.71774910
19	WNK4	1.63113317
20	FRK	1.58968503
21	NME1	1.49464104
22	MUSK	1.42066886
23	PASK	1.42038271
24	TEC	1.37015255
25	VRK1	1.33871188
26	CDK19	1.33091146
27	MYLK	1.28882628
28	INSRR	1.25974523
29	AKT3	1.24198609
30	DAPK2	1.23047316
31	NME2	1.20600953
32	KIT	1.20452225
33	PIM2	1.19780767
34	GRK7	1.18326439
35	ITK	1.18207603
36	STK16	1.18087696
37	PRKCQ	1.16040077
38	RPS6KA5	1.12245057
39	FES	1.10777352
40	DYRK2	1.10056973
41	SYK	1.07622293
42	LCK	1.04832822
43	IKBKB	1.03795534
44	ADRBK1	1.01842474
45	DAPK3	0.99191005
46	OBSCN	0.95000355
47	CSF1R	0.94883772
48	ILK	0.89769411
49	BTK	0.87826927
50	EIF2AK3	0.87693621
51	WNK3	0.87496264
52	PIK3CG	0.85066196
53	MAP3K11	0.81696145
54	LYN	0.81240728
55	NEK1	0.80261537
56	LRRK2	0.73743954
57	PINK1	0.72830360
58	CSNK2A2	0.71027026
59	ZAP70	0.70700655
60	RPS6KB2	0.68386874
61	FLT3	0.67613460
62	MATK	0.66149215
63	JAK3	0.65759951
64	STK39	0.64046906
65	OXSR1	0.63836894
66	CSNK2A1	0.61579152
67	PRKACA	0.61486791
68	PIM1	0.61021222
69	GRK6	0.58317707
70	ROCK1	0.58247710
71	TNK2	0.57971150
72	PRKCA	0.56892069
73	MAP2K7	0.56580469
74	AURKA	0.56495004
75	PLK4	0.56220045
76	BMPR2	0.52738510
77	PRKCG	0.52372123
78	CSK	0.50449080
79	CHEK2	0.49950386
80	PRKCE	0.47555600
81	ABL2	0.46931539
82	MAPK15	0.46622125
83	IGF1R	0.45315170
84	RPS6KA6	0.44451586
85	PRKCD	0.44421857
86	CAMK2A	0.43692231
87	MAPKAPK5	0.43218560
88	AURKB	0.42471589
89	DAPK1	0.41877089
90	GRK5	0.41512485
91	MAP2K6	0.41328646
92	IKBKE	0.39570198
93	MINK1	0.39227779
94	MAP3K4	0.39147410
95	BMPR1B	0.37809070
96	CAMKK2	0.36631488
97	PAK1	0.36582765
98	CSNK1A1	0.33577492
99	RPS6KC1	0.31952916
100	RPS6KL1	0.31952916

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.05417528
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.43354875
3	Parkinsons disease_Homo sapiens_hsa05012	3.56072470
4	Proteasome_Homo sapiens_hsa03050	3.31038101
5	Primary immunodeficiency_Homo sapiens_hsa05340	2.86979030
6	Alzheimers disease_Homo sapiens_hsa05010	2.62194908
7	Asthma_Homo sapiens_hsa05310	2.47318795
8	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.43630569
9	Huntingtons disease_Homo sapiens_hsa05016	2.40665066
10	Allograft rejection_Homo sapiens_hsa05330	2.37119486
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.28552036
12	Cardiac muscle contraction_Homo sapiens_hsa04260	2.17548667
13	Protein export_Homo sapiens_hsa03060	2.14167324
14	Graft-versus-host disease_Homo sapiens_hsa05332	2.13791278
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.93596130
16	RNA polymerase_Homo sapiens_hsa03020	1.92598034
17	Antigen processing and presentation_Homo sapiens_hsa04612	1.84364609
18	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.78577677
19	Type I diabetes mellitus_Homo sapiens_hsa04940	1.72881746
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.69484431
21	Phototransduction_Homo sapiens_hsa04744	1.65604521
22	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.50737357
23	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.38423627
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.35202728
25	Homologous recombination_Homo sapiens_hsa03440	1.34620350
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.34453047
27	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.32243507
28	Rheumatoid arthritis_Homo sapiens_hsa05323	1.14341573
29	Sulfur relay system_Homo sapiens_hsa04122	1.08681875
30	Butanoate metabolism_Homo sapiens_hsa00650	1.05658802
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.04506317
32	DNA replication_Homo sapiens_hsa03030	1.02817336
33	RNA degradation_Homo sapiens_hsa03018	1.01671819
34	Nucleotide excision repair_Homo sapiens_hsa03420	1.01578570
35	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.98875748
36	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.94744459
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.93997009
38	Nitrogen metabolism_Homo sapiens_hsa00910	0.93901189
39	Caffeine metabolism_Homo sapiens_hsa00232	0.92368122
40	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.87726727
41	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.87527894
42	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.85256149
43	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.83217557
44	Purine metabolism_Homo sapiens_hsa00230	0.81651052
45	Fat digestion and absorption_Homo sapiens_hsa04975	0.80866110
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.80059261
47	Fanconi anemia pathway_Homo sapiens_hsa03460	0.77608996
48	Basal transcription factors_Homo sapiens_hsa03022	0.75655677
49	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.73745111
50	Viral myocarditis_Homo sapiens_hsa05416	0.71386409
51	Olfactory transduction_Homo sapiens_hsa04740	0.71306476
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69706977
53	Nicotine addiction_Homo sapiens_hsa05033	0.66978398
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.66258764
55	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.65870181
56	Spliceosome_Homo sapiens_hsa03040	0.64704181
57	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.63909947
58	Tryptophan metabolism_Homo sapiens_hsa00380	0.62819252
59	Collecting duct acid secretion_Homo sapiens_hsa04966	0.62676417
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.62402712
61	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.61670303
62	One carbon pool by folate_Homo sapiens_hsa00670	0.61526050
63	Peroxisome_Homo sapiens_hsa04146	0.60906940
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60247620
65	Sulfur metabolism_Homo sapiens_hsa00920	0.59972616
66	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.58990793
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.57415887
68	Metabolic pathways_Homo sapiens_hsa01100	0.56809256
69	Propanoate metabolism_Homo sapiens_hsa00640	0.55231169
70	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.50301828
71	Ether lipid metabolism_Homo sapiens_hsa00565	0.50041296
72	Measles_Homo sapiens_hsa05162	0.49644351
73	Retinol metabolism_Homo sapiens_hsa00830	0.48870039
74	beta-Alanine metabolism_Homo sapiens_hsa00410	0.46895418
75	Taste transduction_Homo sapiens_hsa04742	0.43473532
76	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.42721325
77	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.41970649
78	Malaria_Homo sapiens_hsa05144	0.40789562
79	Mismatch repair_Homo sapiens_hsa03430	0.38223949
80	Base excision repair_Homo sapiens_hsa03410	0.38184248
81	RNA transport_Homo sapiens_hsa03013	0.37761320
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.33828722
83	Phenylalanine metabolism_Homo sapiens_hsa00360	0.33577528
84	Tyrosine metabolism_Homo sapiens_hsa00350	0.32734272
85	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.30242656
86	Regulation of autophagy_Homo sapiens_hsa04140	0.28846725
87	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.28633424
88	Mineral absorption_Homo sapiens_hsa04978	0.27808590
89	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.27116844
90	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.26960005
91	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.23860575
92	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.22121105
93	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.21829497
94	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.21297785
95	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.20848942
96	African trypanosomiasis_Homo sapiens_hsa05143	0.20769296
97	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.20358222
98	Morphine addiction_Homo sapiens_hsa05032	0.19498470
99	Salivary secretion_Homo sapiens_hsa04970	0.17845200
100	Leishmaniasis_Homo sapiens_hsa05140	0.13620851

RPL24P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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