RPL24P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)8.30393459
2viral transcription (GO:0019083)7.43216601
3translational termination (GO:0006415)7.07892629
4lens fiber cell development (GO:0070307)6.09264996
5ribosomal small subunit assembly (GO:0000028)6.00110585
6translational elongation (GO:0006414)5.96089770
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.89765101
8cotranslational protein targeting to membrane (GO:0006613)5.81456047
9protein targeting to ER (GO:0045047)5.81095571
10maturation of SSU-rRNA (GO:0030490)5.62881464
11establishment of protein localization to endoplasmic reticulum (GO:0072599)5.59643581
12cullin deneddylation (GO:0010388)5.46313283
13protein localization to endoplasmic reticulum (GO:0070972)5.44975566
14viral life cycle (GO:0019058)5.35732684
15cellular protein complex disassembly (GO:0043624)5.31791274
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.16063797
17protein deneddylation (GO:0000338)4.88151411
18energy coupled proton transport, down electrochemical gradient (GO:0015985)4.76860581
19ATP synthesis coupled proton transport (GO:0015986)4.76860581
20behavioral response to nicotine (GO:0035095)4.72642384
21base-excision repair, AP site formation (GO:0006285)4.47193414
22protein complex disassembly (GO:0043241)4.42847869
23regulation of isotype switching to IgG isotypes (GO:0048302)4.38511897
24activated T cell proliferation (GO:0050798)4.37080074
25ncRNA 3-end processing (GO:0043628)4.31064263
26translational initiation (GO:0006413)4.25174244
27macromolecular complex disassembly (GO:0032984)4.14744254
28ribosomal large subunit biogenesis (GO:0042273)4.13468832
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.12624119
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.82487354
31substrate-independent telencephalic tangential migration (GO:0021826)3.82438395
32substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.82438395
33cell proliferation in forebrain (GO:0021846)3.81337954
34protein targeting to membrane (GO:0006612)3.79186151
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.75391364
36nuclear-transcribed mRNA catabolic process (GO:0000956)3.72843599
37kidney morphogenesis (GO:0060993)3.67930478
38translation (GO:0006412)3.58995820
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.58906578
40chaperone-mediated protein transport (GO:0072321)3.54606254
41mRNA catabolic process (GO:0006402)3.49250331
42ribonucleoprotein complex biogenesis (GO:0022613)3.46735134
43pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.45177540
44establishment of protein localization to mitochondrial membrane (GO:0090151)3.42576449
45mitochondrial respiratory chain complex I assembly (GO:0032981)3.35169871
46NADH dehydrogenase complex assembly (GO:0010257)3.35169871
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35169871
48pyrimidine nucleobase catabolic process (GO:0006208)3.31860994
49cellular component biogenesis (GO:0044085)3.26771293
50protein complex biogenesis (GO:0070271)3.26029009
51protein neddylation (GO:0045116)3.23971090
52dopamine transport (GO:0015872)3.23643326
53protein polyglutamylation (GO:0018095)3.15360836
54respiratory electron transport chain (GO:0022904)3.11637524
55electron transport chain (GO:0022900)3.10026550
56arginine metabolic process (GO:0006525)3.07511584
57RNA catabolic process (GO:0006401)3.07341699
58parturition (GO:0007567)3.06296442
59spinal cord association neuron differentiation (GO:0021527)3.01716128
60DNA deamination (GO:0045006)2.97180524
61regulation of B cell receptor signaling pathway (GO:0050855)2.96345153
62epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.95096914
63positive regulation of T cell apoptotic process (GO:0070234)2.93781585
64mitochondrial respiratory chain complex assembly (GO:0033108)2.93550087
65epithelial cilium movement (GO:0003351)2.91923021
66nonmotile primary cilium assembly (GO:0035058)2.90085621
67arginine catabolic process (GO:0006527)2.89211004
68pyrimidine nucleotide catabolic process (GO:0006244)2.81657501
69ATP biosynthetic process (GO:0006754)2.68203126
70nucleobase catabolic process (GO:0046113)2.66664545
71exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66086731
72magnesium ion transport (GO:0015693)2.65958338
73organic cation transport (GO:0015695)2.65475074
74cellular response to exogenous dsRNA (GO:0071360)2.64893351
75nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.64828423
76regulation of appetite (GO:0032098)2.63130049
77purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.58043080
78cardiovascular system development (GO:0072358)2.54716476
79purine nucleoside triphosphate biosynthetic process (GO:0009145)2.53508185
80nucleobase biosynthetic process (GO:0046112)2.52607003
81establishment of protein localization to membrane (GO:0090150)2.52091442
82interferon-gamma production (GO:0032609)2.50429500
83lysosome localization (GO:0032418)2.47632434
84tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.47190261
85RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.47190261
86water-soluble vitamin biosynthetic process (GO:0042364)2.46635969
87synaptic transmission, cholinergic (GO:0007271)2.46118085
88somite development (GO:0061053)2.44557774
89rRNA processing (GO:0006364)2.44438213
90regulation of cilium movement (GO:0003352)2.43176078
91negative regulation of response to food (GO:0032096)2.42301792
92negative regulation of appetite (GO:0032099)2.42301792
93regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.42185464
94hypothalamus development (GO:0021854)2.41523780
95negative regulation of transcription regulatory region DNA binding (GO:2000678)2.40924720
96hydrogen ion transmembrane transport (GO:1902600)2.40844786
97response to redox state (GO:0051775)2.37694113
98rRNA metabolic process (GO:0016072)2.36393633
99pyrimidine-containing compound catabolic process (GO:0072529)2.34324469
100axon ensheathment in central nervous system (GO:0032291)2.33794963

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.62991246
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.77280202
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.22013795
4CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.72120721
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.61393413
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.49807335
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.49005326
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.37735647
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.37335446
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.20684353
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13579026
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.11946953
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10610425
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.07139842
15EZH2_27294783_Chip-Seq_ESCs_Mouse2.04496967
16SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03732388
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.00453183
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.98804507
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94898631
20JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82414403
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.78442152
22ZNF274_21170338_ChIP-Seq_K562_Hela1.74226202
23VDR_22108803_ChIP-Seq_LS180_Human1.70670026
24RNF2_27304074_Chip-Seq_NSC_Mouse1.66421554
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66374829
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.66201192
27REST_21632747_ChIP-Seq_MESCs_Mouse1.60062302
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59309958
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58272873
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58272873
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.52679244
32GBX2_23144817_ChIP-Seq_PC3_Human1.51198330
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.51111317
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51031554
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.50502995
36GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.50010134
37CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39017008
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38876002
39TAF2_19829295_ChIP-Seq_ESCs_Human1.38618537
40GATA1_26923725_Chip-Seq_HPCs_Mouse1.38596290
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.34403635
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.34018672
43TP53_20018659_ChIP-ChIP_R1E_Mouse1.33768546
44NANOG_20526341_ChIP-Seq_ESCs_Human1.33256244
45SOX2_18555785_ChIP-Seq_MESCs_Mouse1.32998823
46SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.31014427
47NCOR_22424771_ChIP-Seq_293T_Human1.30219534
48BCAT_22108803_ChIP-Seq_LS180_Human1.29043261
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26623402
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.24883432
51CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.23670914
52MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21960621
53EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.21513607
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18611350
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17684376
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17187188
57JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17079002
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17061952
59CTCF_27219007_Chip-Seq_Bcells_Human1.16881541
60RING1B_27294783_Chip-Seq_ESCs_Mouse1.15768487
61ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15730238
62SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14646773
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14111472
64TDRD3_21172665_ChIP-Seq_MCF-7_Human1.13756110
65ERA_21632823_ChIP-Seq_H3396_Human1.13498428
66RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.11879156
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10736963
68BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.10561460
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09368193
70E2F1_20622854_ChIP-Seq_HELA_Human1.08325047
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.07382628
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07382628
73TP53_22573176_ChIP-Seq_HFKS_Human1.06682987
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.05679368
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04699983
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04642296
77HTT_18923047_ChIP-ChIP_STHdh_Human1.02008931
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00962082
79GATA3_21878914_ChIP-Seq_MCF-7_Human1.00299055
80P300_19829295_ChIP-Seq_ESCs_Human0.99764715
81AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99386422
82EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98573122
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98537713
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98537713
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98421340
86OCT4_19829295_ChIP-Seq_ESCs_Human0.97520819
87YY1_22570637_ChIP-Seq_MALME-3M_Human0.97229142
88EWS_26573619_Chip-Seq_HEK293_Human0.97197842
89GATA3_21867929_ChIP-Seq_TH1_Mouse0.96792126
90PHF8_20622854_ChIP-Seq_HELA_Human0.96504437
91SA1_27219007_Chip-Seq_Bcells_Human0.96463304
92CTCF_20526341_ChIP-Seq_ESCs_Human0.94034383
93MYC_19829295_ChIP-Seq_ESCs_Human0.93645780
94MYC_18555785_ChIP-Seq_MESCs_Mouse0.92800590
95ELF1_20517297_ChIP-Seq_JURKAT_Human0.92626629
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92567124
97RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91551446
98MYC_18940864_ChIP-ChIP_HL60_Human0.89570504
99SOX2_19829295_ChIP-Seq_ESCs_Human0.89237823
100NANOG_19829295_ChIP-Seq_ESCs_Human0.89237823

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.30935988
2MP0006082_CNS_inflammation4.30231069
3MP0009379_abnormal_foot_pigmentation4.16732456
4MP0003787_abnormal_imprinting2.93042743
5MP0002132_abnormal_respiratory_system2.73736605
6MP0002163_abnormal_gland_morphology2.46590788
7MP0002837_dystrophic_cardiac_calcinosis2.23867668
8MP0002876_abnormal_thyroid_physiology2.22101072
9MP0008789_abnormal_olfactory_epithelium2.10925402
10MP0003123_paternal_imprinting2.08708146
11MP0003121_genomic_imprinting1.96309743
12MP0004142_abnormal_muscle_tone1.93730854
13MP0002102_abnormal_ear_morphology1.89451373
14MP0002160_abnormal_reproductive_system1.89416972
15MP0002653_abnormal_ependyma_morphology1.89134071
16MP0003646_muscle_fatigue1.87576020
17MP0008877_abnormal_DNA_methylation1.86465641
18MP0003879_abnormal_hair_cell1.84504488
19MP0005646_abnormal_pituitary_gland1.83746902
20MP0004885_abnormal_endolymph1.69359848
21MP0001905_abnormal_dopamine_level1.69039566
22MP0005394_taste/olfaction_phenotype1.62033118
23MP0005499_abnormal_olfactory_system1.62033118
24MP0001873_stomach_inflammation1.57396318
25MP0005423_abnormal_somatic_nervous1.57266066
26MP0000049_abnormal_middle_ear1.56671519
27MP0002736_abnormal_nociception_after1.53388074
28MP0001968_abnormal_touch/_nociception1.52790642
29MP0002638_abnormal_pupillary_reflex1.49995819
30MP0003880_abnormal_central_pattern1.46957211
31MP0005408_hypopigmentation1.46705832
32MP0005645_abnormal_hypothalamus_physiol1.45042603
33MP0000778_abnormal_nervous_system1.41501378
34MP0005551_abnormal_eye_electrophysiolog1.40606501
35MP0003122_maternal_imprinting1.40049185
36MP0003878_abnormal_ear_physiology1.38798561
37MP0005377_hearing/vestibular/ear_phenot1.38798561
38MP0006276_abnormal_autonomic_nervous1.36757906
39MP0004742_abnormal_vestibular_system1.34246053
40MP0005671_abnormal_response_to1.32889254
41MP0008875_abnormal_xenobiotic_pharmacok1.32521294
42MP0002272_abnormal_nervous_system1.32078055
43MP0002184_abnormal_innervation1.31134606
44MP0002822_catalepsy1.29341352
45MP0004145_abnormal_muscle_electrophysio1.26375463
46MP0005379_endocrine/exocrine_gland_phen1.25232880
47MP0005195_abnormal_posterior_eye1.23036001
48MP0005389_reproductive_system_phenotype1.22851182
49MP0008872_abnormal_physiological_respon1.22775208
50MP0006072_abnormal_retinal_apoptosis1.16113742
51MP0000631_abnormal_neuroendocrine_gland1.15853515
52MP0001485_abnormal_pinna_reflex1.15479864
53MP0002557_abnormal_social/conspecific_i1.15118295
54MP0003011_delayed_dark_adaptation1.14873081
55MP0001986_abnormal_taste_sensitivity1.14000165
56MP0009745_abnormal_behavioral_response1.13666845
57MP0000026_abnormal_inner_ear1.13230080
58MP0005167_abnormal_blood-brain_barrier1.11675277
59MP0002572_abnormal_emotion/affect_behav1.11123798
60MP0002752_abnormal_somatic_nervous1.05214342
61MP0003938_abnormal_ear_development1.03206390
62MP0001440_abnormal_grooming_behavior1.02453833
63MP0001663_abnormal_digestive_system1.00947572
64MP0002063_abnormal_learning/memory/cond1.00712970
65MP0008775_abnormal_heart_ventricle0.98838467
66MP0003635_abnormal_synaptic_transmissio0.98284162
67MP0001727_abnormal_embryo_implantation0.96658361
68MP0001970_abnormal_pain_threshold0.95550858
69MP0000678_abnormal_parathyroid_gland0.94084986
70MP0000955_abnormal_spinal_cord0.92522457
71MP0003690_abnormal_glial_cell0.91214035
72MP0002938_white_spotting0.89958453
73MP0003718_maternal_effect0.88220529
74MP0001293_anophthalmia0.87966996
75MP0010030_abnormal_orbit_morphology0.87456980
76MP0001529_abnormal_vocalization0.85022944
77MP0002733_abnormal_thermal_nociception0.84519159
78MP0009333_abnormal_splenocyte_physiolog0.83067077
79MP0002735_abnormal_chemical_nociception0.82796979
80MP0001963_abnormal_hearing_physiology0.82188768
81MP0001984_abnormal_olfaction0.81376808
82MP0004130_abnormal_muscle_cell0.80805758
83MP0000230_abnormal_systemic_arterial0.78710437
84MP0002067_abnormal_sensory_capabilities0.78580119
85MP0004133_heterotaxia0.77167518
86MP0004510_myositis0.76465223
87MP0003567_abnormal_fetal_cardiomyocyte0.75217763
88MP0003195_calcinosis0.74918493
89MP0002882_abnormal_neuron_morphology0.74593734
90MP0009697_abnormal_copulation0.73458258
91MP0002210_abnormal_sex_determination0.71866803
92MP0001286_abnormal_eye_development0.71745739
93MP0002095_abnormal_skin_pigmentation0.71005546
94MP0009046_muscle_twitch0.69560734
95MP0003119_abnormal_digestive_system0.69548748
96MP0005253_abnormal_eye_physiology0.68181846
97MP0001486_abnormal_startle_reflex0.67688463
98MP0009764_decreased_sensitivity_to0.67430588
99MP0003186_abnormal_redox_activity0.66167357
100MP0002138_abnormal_hepatobiliary_system0.65010486

Predicted human phenotypes

RankGene SetZ-score
1Macrocytic anemia (HP:0001972)4.38180857
2Reticulocytopenia (HP:0001896)4.04114411
3Abnormality of cells of the erythroid lineage (HP:0012130)4.03264810
4Molar tooth sign on MRI (HP:0002419)3.64977218
5Abnormality of midbrain morphology (HP:0002418)3.64977218
6Acute necrotizing encephalopathy (HP:0006965)3.48858502
7Abnormality of macular pigmentation (HP:0008002)3.38744651
8Colon cancer (HP:0003003)3.38154011
9Pancreatic fibrosis (HP:0100732)3.32703670
10Nasal polyposis (HP:0100582)3.16238537
11Abnormal mitochondria in muscle tissue (HP:0008316)3.04129509
12Hyperthyroidism (HP:0000836)3.03575482
13Acute encephalopathy (HP:0006846)2.99642363
14Congenital stationary night blindness (HP:0007642)2.98092336
15Aplasia/Hypoplasia of the spleen (HP:0010451)2.92676489
16Asplenia (HP:0001746)2.91448538
17Abnormal number of erythroid precursors (HP:0012131)2.90682601
18Abnormality of pyrimidine metabolism (HP:0004353)2.87402519
193-Methylglutaconic aciduria (HP:0003535)2.87247155
20Medial flaring of the eyebrow (HP:0010747)2.85368982
21Progressive macrocephaly (HP:0004481)2.84862089
22Mitochondrial inheritance (HP:0001427)2.84294148
23True hermaphroditism (HP:0010459)2.81847003
24Thrombocytosis (HP:0001894)2.81566804
25Septo-optic dysplasia (HP:0100842)2.80649905
26Pancreatic cysts (HP:0001737)2.79101334
27Elevated erythrocyte sedimentation rate (HP:0003565)2.76566757
28Stenosis of the external auditory canal (HP:0000402)2.73495784
29Status epilepticus (HP:0002133)2.70977051
30Attenuation of retinal blood vessels (HP:0007843)2.67868221
31Decreased electroretinogram (ERG) amplitude (HP:0000654)2.66881099
32Agitation (HP:0000713)2.63760584
33Pallor (HP:0000980)2.62453755
34Optic disc pallor (HP:0000543)2.58490848
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.57614725
36Constricted visual fields (HP:0001133)2.48367064
37Nephronophthisis (HP:0000090)2.46524987
38Abnormal rod and cone electroretinograms (HP:0008323)2.45354946
39Zonular cataract (HP:0010920)2.42740237
40Abnormality of the nasal mucosa (HP:0000433)2.41418779
41Increased CSF lactate (HP:0002490)2.34979695
42Rib fusion (HP:0000902)2.31921337
43Abnormality of the renal medulla (HP:0100957)2.26010069
44Myokymia (HP:0002411)2.24988760
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.24562083
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.24562083
47Adrenal hypoplasia (HP:0000835)2.22165009
48Renal dysplasia (HP:0000110)2.18278794
49Hemiplegia (HP:0002301)2.16689562
50Anencephaly (HP:0002323)2.15091869
51Hypsarrhythmia (HP:0002521)2.12307859
52Type II lissencephaly (HP:0007260)2.12103969
53Pendular nystagmus (HP:0012043)2.11756431
54Cerebral edema (HP:0002181)2.11075237
55Thyroid-stimulating hormone excess (HP:0002925)2.07808294
56Cystic liver disease (HP:0006706)2.07308033
57Oligodontia (HP:0000677)2.07004498
58Epileptiform EEG discharges (HP:0011182)2.05443362
59Absent/shortened dynein arms (HP:0200106)2.04284649
60Dynein arm defect of respiratory motile cilia (HP:0012255)2.04284649
61Absent thumb (HP:0009777)2.03701670
62Megaloblastic anemia (HP:0001889)2.02734111
63Sclerocornea (HP:0000647)2.01989139
64Hyperglycinemia (HP:0002154)2.00993485
65EEG with generalized epileptiform discharges (HP:0011198)2.00730988
66Striae distensae (HP:0001065)1.99072481
67Gait imbalance (HP:0002141)1.96533109
68Hepatocellular necrosis (HP:0001404)1.96528203
69Postaxial foot polydactyly (HP:0001830)1.94100076
70Supernumerary spleens (HP:0009799)1.93725530
71Abnormal respiratory epithelium morphology (HP:0012253)1.91225673
72Abnormal respiratory motile cilium morphology (HP:0005938)1.91225673
73Increased hepatocellular lipid droplets (HP:0006565)1.91064922
74Depressed nasal ridge (HP:0000457)1.89574880
75Congenital primary aphakia (HP:0007707)1.87885322
76Oligodactyly (hands) (HP:0001180)1.87706814
77Lipid accumulation in hepatocytes (HP:0006561)1.85647309
78Aplasia/Hypoplasia of the sacrum (HP:0008517)1.85122344
79Diastasis recti (HP:0001540)1.84614156
80Absent septum pellucidum (HP:0001331)1.84521798
81Volvulus (HP:0002580)1.84040387
82Abnormal number of incisors (HP:0011064)1.83660869
83Polydipsia (HP:0001959)1.83626676
84Abnormal drinking behavior (HP:0030082)1.83626676
85Optic nerve hypoplasia (HP:0000609)1.83574258
86Oligodactyly (HP:0012165)1.82047803
87Maternal diabetes (HP:0009800)1.80456389
88Horseshoe kidney (HP:0000085)1.79982506
89Exertional dyspnea (HP:0002875)1.79790931
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79780212
91Hepatic necrosis (HP:0002605)1.79507368
92Abnormal ciliary motility (HP:0012262)1.78079510
93Severe visual impairment (HP:0001141)1.77021085
94Postaxial hand polydactyly (HP:0001162)1.76319303
95Epileptic encephalopathy (HP:0200134)1.75929748
96Nephrogenic diabetes insipidus (HP:0009806)1.74740730
97Type 2 muscle fiber atrophy (HP:0003554)1.74382825
98Polyuria (HP:0000103)1.74173021
99Abnormality of the labia minora (HP:0012880)1.73281306
100Male pseudohermaphroditism (HP:0000037)1.72437045

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK43.18777491
2STK162.64906969
3PIK3CA2.63767495
4VRK22.63575600
5ITK2.52694173
6NUAK12.29905903
7KIT2.17725782
8ADRBK22.10198725
9STK392.10149019
10CASK2.04357312
11GRK12.03710652
12TIE11.99537337
13PINK11.96426956
14BCKDK1.88949263
15DYRK21.88267036
16TESK21.78373947
17CDK191.76319740
18PRKCH1.66346996
19FES1.64554075
20CAMKK21.64363075
21NTRK21.53100051
22LIMK11.51696804
23FRK1.51441779
24MAP4K21.48117532
25PRKD21.45274132
26INSRR1.43277375
27TYRO31.42415109
28TEC1.40369278
29VRK11.33538808
30TAOK31.33342841
31EPHB21.29862350
32PTK2B1.25415620
33WNK31.19174355
34MAP3K41.18966472
35MUSK1.18098062
36MAP2K71.11079789
37EPHA41.08792704
38ZAK1.05878726
39PRKCG1.03567331
40LRRK21.02747898
41TXK0.95161558
42ADRBK10.94982490
43PAK30.86916901
44CAMKK10.86793842
45BRAF0.86531446
46PASK0.85334839
47KDR0.82045782
48PRKCQ0.81957500
49CAMK10.81931273
50BTK0.81274765
51MINK10.81052413
52TLK10.80930825
53IKBKB0.80133378
54PRKCE0.77533068
55PRKACA0.77526908
56CAMK1D0.77489118
57ZAP700.77391099
58BMPR1B0.76587991
59OXSR10.76153223
60OBSCN0.75501567
61PRKCZ0.75308840
62CHEK20.75282922
63RPS6KA60.74032471
64MAP3K120.73012840
65DAPK30.66354782
66PLK40.64365857
67GSK3A0.63778647
68DYRK30.62356095
69CSNK1A10.62139054
70PRKACG0.61392732
71PIM10.60169820
72WNK10.59277836
73SYK0.57695780
74SGK4940.56647616
75SGK2230.56647616
76MAPK150.55916659
77MAP3K110.55612693
78MYLK0.54954246
79PRKCA0.54804082
80RPS6KL10.52172219
81RPS6KC10.52172219
82PIM20.48530178
83MAP3K70.48456828
84DYRK1B0.47366188
85ABL20.46479350
86CSK0.46352836
87RPS6KA50.45835344
88CSNK1G20.44388138
89CAMK2A0.44197848
90MAPK70.43940428
91PRKCD0.43771538
92MARK10.43284632
93GRK70.42814924
94AURKA0.41631486
95NTRK30.41089357
96CSNK2A20.41016614
97NME20.40877880
98PRKG20.40066535
99AURKB0.39744635
100PLK10.39644161

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.97007287
2Oxidative phosphorylation_Homo sapiens_hsa001904.17055870
3Parkinsons disease_Homo sapiens_hsa050123.36937892
4Cardiac muscle contraction_Homo sapiens_hsa042602.57208298
5Alzheimers disease_Homo sapiens_hsa050102.26807200
6Graft-versus-host disease_Homo sapiens_hsa053322.26793669
7Huntingtons disease_Homo sapiens_hsa050162.25773005
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.21527672
9Phototransduction_Homo sapiens_hsa047442.07450810
10Protein export_Homo sapiens_hsa030602.07064308
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.96579014
12Linoleic acid metabolism_Homo sapiens_hsa005911.71526571
13Drug metabolism - other enzymes_Homo sapiens_hsa009831.68243109
14RNA degradation_Homo sapiens_hsa030181.59095552
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57740205
16Nicotine addiction_Homo sapiens_hsa050331.49468020
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48830598
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44502178
19RNA polymerase_Homo sapiens_hsa030201.43283454
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39589613
21Basal transcription factors_Homo sapiens_hsa030221.38860240
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36262194
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31764451
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.29809953
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.28895196
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23614312
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.22438294
28Base excision repair_Homo sapiens_hsa034101.17798986
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09352324
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07939359
31Pyrimidine metabolism_Homo sapiens_hsa002401.06288885
32Caffeine metabolism_Homo sapiens_hsa002321.05328980
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03937182
34Autoimmune thyroid disease_Homo sapiens_hsa053201.02157567
35Allograft rejection_Homo sapiens_hsa053301.01658285
36beta-Alanine metabolism_Homo sapiens_hsa004101.01561075
37Retinol metabolism_Homo sapiens_hsa008300.97670006
38Peroxisome_Homo sapiens_hsa041460.96202075
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96152466
40Steroid biosynthesis_Homo sapiens_hsa001000.94108738
41Tryptophan metabolism_Homo sapiens_hsa003800.93910300
42Chemical carcinogenesis_Homo sapiens_hsa052040.90534024
43Butanoate metabolism_Homo sapiens_hsa006500.88887724
44Arachidonic acid metabolism_Homo sapiens_hsa005900.88488109
45Nitrogen metabolism_Homo sapiens_hsa009100.88124182
46Proteasome_Homo sapiens_hsa030500.87118117
47Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86173616
48Olfactory transduction_Homo sapiens_hsa047400.85399398
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84385787
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82799615
51Arginine and proline metabolism_Homo sapiens_hsa003300.82351333
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.81629650
53Homologous recombination_Homo sapiens_hsa034400.79564969
54Asthma_Homo sapiens_hsa053100.78870756
55Morphine addiction_Homo sapiens_hsa050320.76858147
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75437152
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72927956
58Fat digestion and absorption_Homo sapiens_hsa049750.69412453
59Sulfur relay system_Homo sapiens_hsa041220.67848553
60Spliceosome_Homo sapiens_hsa030400.63792049
61Metabolic pathways_Homo sapiens_hsa011000.62768957
62Basal cell carcinoma_Homo sapiens_hsa052170.62516921
63Type I diabetes mellitus_Homo sapiens_hsa049400.61564310
64Hedgehog signaling pathway_Homo sapiens_hsa043400.61397455
65Primary immunodeficiency_Homo sapiens_hsa053400.61056384
66Rheumatoid arthritis_Homo sapiens_hsa053230.60348298
67Ether lipid metabolism_Homo sapiens_hsa005650.55266810
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54128890
69Taste transduction_Homo sapiens_hsa047420.53989302
70Fanconi anemia pathway_Homo sapiens_hsa034600.53936209
71Antigen processing and presentation_Homo sapiens_hsa046120.53558226
72Purine metabolism_Homo sapiens_hsa002300.52491236
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.52390991
74GABAergic synapse_Homo sapiens_hsa047270.50630514
75Arginine biosynthesis_Homo sapiens_hsa002200.50111728
76Propanoate metabolism_Homo sapiens_hsa006400.48514122
77Insulin secretion_Homo sapiens_hsa049110.48063766
78Ovarian steroidogenesis_Homo sapiens_hsa049130.47260536
79Serotonergic synapse_Homo sapiens_hsa047260.46652347
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46147148
81One carbon pool by folate_Homo sapiens_hsa006700.45911588
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45317639
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42367770
84Glutamatergic synapse_Homo sapiens_hsa047240.41468344
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40469802
86Malaria_Homo sapiens_hsa051440.37304599
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37090507
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36724387
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36548162
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.36275092
91Collecting duct acid secretion_Homo sapiens_hsa049660.35879395
92Tyrosine metabolism_Homo sapiens_hsa003500.34451437
93Hematopoietic cell lineage_Homo sapiens_hsa046400.33133385
94Pyruvate metabolism_Homo sapiens_hsa006200.31744441
95Axon guidance_Homo sapiens_hsa043600.31519203
96Mismatch repair_Homo sapiens_hsa034300.31258286
97Fatty acid degradation_Homo sapiens_hsa000710.28921763
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.28375843
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28132103
100Nucleotide excision repair_Homo sapiens_hsa034200.26828129

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