RPL26L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that shares high sequence similarity with ribosomal protein L26. Alternative splicing results in multiple transcript variants encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.14726051
2ATP synthesis coupled proton transport (GO:0015986)6.08302744
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.08302744
4chaperone-mediated protein transport (GO:0072321)5.82922154
5ribosomal small subunit biogenesis (GO:0042274)5.75850408
6* viral transcription (GO:0019083)5.59359661
7establishment of protein localization to mitochondrial membrane (GO:0090151)5.55939323
8* translational termination (GO:0006415)5.45744658
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.20949697
10* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.17539426
11* cotranslational protein targeting to membrane (GO:0006613)5.14335653
12* protein targeting to ER (GO:0045047)5.08400808
13ribosomal small subunit assembly (GO:0000028)4.97706212
14respiratory electron transport chain (GO:0022904)4.96128214
15proteasome assembly (GO:0043248)4.89702081
16* establishment of protein localization to endoplasmic reticulum (GO:0072599)4.88422014
17electron transport chain (GO:0022900)4.86087036
18ribosomal large subunit biogenesis (GO:0042273)4.82696652
19* protein localization to endoplasmic reticulum (GO:0070972)4.78391597
20maturation of SSU-rRNA (GO:0030490)4.66970116
21* translational elongation (GO:0006414)4.66347875
22protein complex biogenesis (GO:0070271)4.48787738
23mitochondrial respiratory chain complex assembly (GO:0033108)4.46026129
24* translational initiation (GO:0006413)4.32185003
25regulation of mitochondrial translation (GO:0070129)4.28178083
26* translation (GO:0006412)4.27921355
27* viral life cycle (GO:0019058)4.27508235
28* cellular protein complex disassembly (GO:0043624)4.20619733
29* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.17552046
30protein neddylation (GO:0045116)4.15944707
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.13902098
32mitochondrial respiratory chain complex I assembly (GO:0032981)4.13902098
33NADH dehydrogenase complex assembly (GO:0010257)4.13902098
34transcription elongation from RNA polymerase III promoter (GO:0006385)4.10313014
35termination of RNA polymerase III transcription (GO:0006386)4.10313014
36negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.08081892
37CENP-A containing nucleosome assembly (GO:0034080)4.05373616
38chromatin remodeling at centromere (GO:0031055)4.00091739
39rRNA modification (GO:0000154)3.97461531
40ribonucleoprotein complex biogenesis (GO:0022613)3.90117696
41cellular component biogenesis (GO:0044085)3.85740305
42positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.84388046
43anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.82449205
44protein targeting to mitochondrion (GO:0006626)3.82244858
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.81191460
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.72486495
47negative regulation of ligase activity (GO:0051352)3.72486495
48exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.62198064
49spliceosomal snRNP assembly (GO:0000387)3.58773374
50nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.58705066
51respiratory chain complex IV assembly (GO:0008535)3.55926799
52establishment of protein localization to mitochondrion (GO:0072655)3.55029279
53rRNA processing (GO:0006364)3.53655766
54* protein complex disassembly (GO:0043241)3.53342679
55protein localization to mitochondrion (GO:0070585)3.51341080
56regulation of cellular amino acid metabolic process (GO:0006521)3.50699630
57cullin deneddylation (GO:0010388)3.46639952
58establishment of integrated proviral latency (GO:0075713)3.44467018
59* macromolecular complex disassembly (GO:0032984)3.43166989
60* protein targeting to membrane (GO:0006612)3.42977648
61rRNA metabolic process (GO:0016072)3.38571465
62ATP biosynthetic process (GO:0006754)3.37753806
63cytochrome complex assembly (GO:0017004)3.36555746
64positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.35961453
65pseudouridine synthesis (GO:0001522)3.33798349
66DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.32697845
67mitotic metaphase plate congression (GO:0007080)3.32048172
68purine nucleoside triphosphate biosynthetic process (GO:0009145)3.31937974
69DNA damage response, detection of DNA damage (GO:0042769)3.29091151
70protein deneddylation (GO:0000338)3.27975400
71DNA replication checkpoint (GO:0000076)3.27868696
72signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.27003149
73signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.27003149
74signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.27003149
75* nuclear-transcribed mRNA catabolic process (GO:0000956)3.26579679
76signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.25239562
77intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.25239562
78histone exchange (GO:0043486)3.24848106
79purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.24722643
80positive regulation of ligase activity (GO:0051351)3.21271413
81telomere maintenance via semi-conservative replication (GO:0032201)3.19257498
82hydrogen ion transmembrane transport (GO:1902600)3.18307056
83signal transduction involved in DNA integrity checkpoint (GO:0072401)3.17968723
84signal transduction involved in DNA damage checkpoint (GO:0072422)3.17968723
85signal transduction involved in cell cycle checkpoint (GO:0072395)3.16092225
86oxidative phosphorylation (GO:0006119)3.15330608
87water-soluble vitamin biosynthetic process (GO:0042364)3.13273678
887-methylguanosine mRNA capping (GO:0006370)3.13195282
89kinetochore organization (GO:0051383)3.12978351
90rRNA methylation (GO:0031167)3.12965119
91protein K6-linked ubiquitination (GO:0085020)3.12368153
92tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.09432772
93RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.09432772
94* mRNA catabolic process (GO:0006402)3.09164810
95inner mitochondrial membrane organization (GO:0007007)3.08033034
967-methylguanosine RNA capping (GO:0009452)3.05389168
97RNA capping (GO:0036260)3.05389168
98DNA replication-independent nucleosome organization (GO:0034724)3.03079553
99DNA replication-independent nucleosome assembly (GO:0006336)3.03079553
100transcription-coupled nucleotide-excision repair (GO:0006283)3.03001301

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.62096969
2* GABP_17652178_ChIP-ChIP_JURKAT_Human5.01938217
3* EST1_17652178_ChIP-ChIP_JURKAT_Human4.61569255
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.96095129
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.94103856
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.88905814
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.66766009
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.56572323
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.28139143
10* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.23714638
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.14264752
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.03334075
13* ELK1_19687146_ChIP-ChIP_HELA_Human2.84724536
14E2F7_22180533_ChIP-Seq_HELA_Human2.84159618
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.73785802
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69927404
17* VDR_23849224_ChIP-Seq_CD4+_Human2.62983805
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.62776020
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.62697213
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.57621416
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53116658
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50005569
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.46369128
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.43623395
25FOXP3_21729870_ChIP-Seq_TREG_Human2.36711678
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.30475188
27DCP1A_22483619_ChIP-Seq_HELA_Human2.26119617
28TTF2_22483619_ChIP-Seq_HELA_Human2.22995630
29XRN2_22483619_ChIP-Seq_HELA_Human2.21707927
30SRF_21415370_ChIP-Seq_HL-1_Mouse2.20653338
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.17708063
32E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11429126
33FOXM1_23109430_ChIP-Seq_U2OS_Human2.06459709
34GABP_19822575_ChIP-Seq_HepG2_Human1.99542948
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98071008
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.97915489
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.91538737
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.88158980
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.79660727
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.76871540
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.76398402
42MYC_18940864_ChIP-ChIP_HL60_Human1.75866751
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69338540
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68823863
45AR_21909140_ChIP-Seq_LNCAP_Human1.58464200
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53544030
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51493121
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50848209
49ELK1_22589737_ChIP-Seq_MCF10A_Human1.50741637
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47619295
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.40883848
52ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.39110064
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38748249
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.35539237
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24811438
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23294127
57EWS_26573619_Chip-Seq_HEK293_Human1.19477557
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18057250
59KDM5A_27292631_Chip-Seq_BREAST_Human1.14279799
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13105152
61ZNF274_21170338_ChIP-Seq_K562_Hela1.12026457
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08880578
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04086645
64FUS_26573619_Chip-Seq_HEK293_Human1.03051813
65VDR_22108803_ChIP-Seq_LS180_Human1.01183408
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00077662
67SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99804210
68NOTCH1_21737748_ChIP-Seq_TLL_Human0.99123736
69POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97977497
70IRF1_19129219_ChIP-ChIP_H3396_Human0.95484589
71NANOG_16153702_ChIP-ChIP_HESCs_Human0.94742697
72KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94314719
73SOX2_16153702_ChIP-ChIP_HESCs_Human0.93857237
74CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92283109
75ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91305752
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90461059
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.88236732
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86328607
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.86097550
80CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.84375266
81SOX17_20123909_ChIP-Seq_XEN_Mouse0.83993021
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83827317
83ELF5_23300383_ChIP-Seq_T47D_Human0.81634060
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.79576207
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.79244582
86* TP53_22573176_ChIP-Seq_HFKS_Human0.79242690
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.79223444
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.78293200
89CTCF_18555785_ChIP-Seq_MESCs_Mouse0.74601359
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.74389035
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.73037578
92HTT_18923047_ChIP-ChIP_STHdh_Human0.71276666
93FLI1_27457419_Chip-Seq_LIVER_Mouse0.70244410
94TP63_19390658_ChIP-ChIP_HaCaT_Human0.69686943
95SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.69571299
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.67118404
97NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.66287454
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.62889304
99ESR1_15608294_ChIP-ChIP_MCF-7_Human0.62503253
100CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.61371858

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.95024161
2MP0003806_abnormal_nucleotide_metabolis3.84924593
3MP0006292_abnormal_olfactory_placode3.50074293
4MP0008058_abnormal_DNA_repair3.49738758
5MP0003718_maternal_effect3.36430925
6MP0003693_abnormal_embryo_hatching3.32534731
7MP0004957_abnormal_blastocyst_morpholog2.94588539
8MP0002938_white_spotting2.93946684
9MP0010094_abnormal_chromosome_stability2.91593225
10MP0003077_abnormal_cell_cycle2.68834710
11MP0002638_abnormal_pupillary_reflex2.62345941
12MP0003186_abnormal_redox_activity2.48270405
13MP0003111_abnormal_nucleus_morphology2.38153576
14MP0008789_abnormal_olfactory_epithelium2.34346886
15MP0010030_abnormal_orbit_morphology2.29749394
16MP0008932_abnormal_embryonic_tissue2.25617485
17MP0008877_abnormal_DNA_methylation2.23366454
18MP0006036_abnormal_mitochondrial_physio2.12967336
19MP0000372_irregular_coat_pigmentation2.06661085
20MP0001529_abnormal_vocalization1.86011856
21MP0006072_abnormal_retinal_apoptosis1.79458853
22MP0003136_yellow_coat_color1.75970411
23MP0002234_abnormal_pharynx_morphology1.74181091
24MP0008007_abnormal_cellular_replicative1.73585554
25MP0009697_abnormal_copulation1.71406018
26MP0003786_premature_aging1.69662403
27MP0003941_abnormal_skin_development1.66027829
28MP0006035_abnormal_mitochondrial_morpho1.63927256
29MP0001293_anophthalmia1.62339065
30MP0002102_abnormal_ear_morphology1.62141857
31MP0002160_abnormal_reproductive_system1.61828483
32MP0005499_abnormal_olfactory_system1.61655366
33MP0005394_taste/olfaction_phenotype1.61655366
34MP0002163_abnormal_gland_morphology1.54255604
35MP0005408_hypopigmentation1.37401323
36MP0008875_abnormal_xenobiotic_pharmacok1.36680431
37MP0002210_abnormal_sex_determination1.35776830
38MP0004142_abnormal_muscle_tone1.27490251
39MP0000049_abnormal_middle_ear1.23829707
40MP0005084_abnormal_gallbladder_morpholo1.23768611
41MP0002837_dystrophic_cardiac_calcinosis1.23469763
42MP0001764_abnormal_homeostasis1.21408211
43MP0003880_abnormal_central_pattern1.17557272
44MP0002277_abnormal_respiratory_mucosa1.14822853
45MP0000631_abnormal_neuroendocrine_gland1.14172592
46MP0002736_abnormal_nociception_after1.13471660
47MP0001929_abnormal_gametogenesis1.12771962
48MP0005389_reproductive_system_phenotype1.10567128
49MP0001905_abnormal_dopamine_level1.08122871
50MP0001286_abnormal_eye_development1.07596697
51MP0005379_endocrine/exocrine_gland_phen1.06401956
52MP0001984_abnormal_olfaction1.04033186
53MP0000358_abnormal_cell_content/1.03671001
54MP0002233_abnormal_nose_morphology1.02629591
55MP0003123_paternal_imprinting1.01582952
56MP0008995_early_reproductive_senescence1.01402579
57MP0005395_other_phenotype1.01348816
58MP0003937_abnormal_limbs/digits/tail_de0.99824078
59MP0000653_abnormal_sex_gland0.98738917
60MP0005551_abnormal_eye_electrophysiolog0.98169340
61MP0005253_abnormal_eye_physiology0.97854707
62MP0001145_abnormal_male_reproductive0.96408416
63MP0001697_abnormal_embryo_size0.95528880
64MP0003195_calcinosis0.94548174
65MP0000350_abnormal_cell_proliferation0.92818785
66MP0003890_abnormal_embryonic-extraembry0.92117784
67MP0005410_abnormal_fertilization0.89267678
68MP0008057_abnormal_DNA_replication0.85948995
69MP0009250_abnormal_appendicular_skeleto0.83359506
70MP0000647_abnormal_sebaceous_gland0.82820075
71MP0002095_abnormal_skin_pigmentation0.81798015
72MP0003755_abnormal_palate_morphology0.81489186
73MP0003315_abnormal_perineum_morphology0.80744016
74MP0003938_abnormal_ear_development0.80290227
75MP0001485_abnormal_pinna_reflex0.80003652
76MP0005195_abnormal_posterior_eye0.79088280
77MP0003121_genomic_imprinting0.78056987
78MP0004133_heterotaxia0.78010455
79MP0008872_abnormal_physiological_respon0.77380694
80MP0003698_abnormal_male_reproductive0.77257526
81MP0002085_abnormal_embryonic_tissue0.77005804
82MP0003011_delayed_dark_adaptation0.76891104
83MP0001730_embryonic_growth_arrest0.76300163
84MP0005391_vision/eye_phenotype0.75305557
85MP0005332_abnormal_amino_acid0.73649786
86MP0000313_abnormal_cell_death0.73329678
87MP0002751_abnormal_autonomic_nervous0.73207032
88MP0002090_abnormal_vision0.72857546
89MP0002111_abnormal_tail_morphology0.68463516
90MP0002697_abnormal_eye_size0.67734501
91MP0009046_muscle_twitch0.66366334
92MP0002084_abnormal_developmental_patter0.66290878
93MP0005646_abnormal_pituitary_gland0.65846069
94MP0001919_abnormal_reproductive_system0.65831947
95MP0003119_abnormal_digestive_system0.65370079
96MP0006276_abnormal_autonomic_nervous0.65269251
97MP0001346_abnormal_lacrimal_gland0.64123114
98MP0002161_abnormal_fertility/fecundity0.63377058
99MP0001968_abnormal_touch/_nociception0.62570538
100MP0001119_abnormal_female_reproductive0.61920460

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.94774975
2Abnormal mitochondria in muscle tissue (HP:0008316)5.40724385
3Mitochondrial inheritance (HP:0001427)5.16820075
4Acute encephalopathy (HP:0006846)5.16751731
5Progressive macrocephaly (HP:0004481)4.93908811
6Increased hepatocellular lipid droplets (HP:0006565)4.86113653
7Increased CSF lactate (HP:0002490)4.72528318
8Lipid accumulation in hepatocytes (HP:0006561)4.31547302
9Hepatocellular necrosis (HP:0001404)4.25009719
10Abnormality of cells of the erythroid lineage (HP:0012130)4.21395505
11Renal Fanconi syndrome (HP:0001994)4.21130222
12Hepatic necrosis (HP:0002605)4.00008688
13Macrocytic anemia (HP:0001972)3.98270569
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.93722416
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.93722416
16Cerebral edema (HP:0002181)3.88383458
17Abnormal number of erythroid precursors (HP:0012131)3.77647277
183-Methylglutaconic aciduria (HP:0003535)3.71018244
19Reticulocytopenia (HP:0001896)3.35046101
20Increased intramyocellular lipid droplets (HP:0012240)3.27773714
21Increased serum lactate (HP:0002151)3.21241999
22Exertional dyspnea (HP:0002875)3.06988558
23Lactic acidosis (HP:0003128)3.06405160
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.05088470
25Respiratory failure (HP:0002878)2.97905903
26Exercise intolerance (HP:0003546)2.85978105
27Leukodystrophy (HP:0002415)2.76663644
28Respiratory difficulties (HP:0002880)2.74476341
29Abnormality of renal resorption (HP:0011038)2.72838641
30Methylmalonic acidemia (HP:0002912)2.67608234
31Type I transferrin isoform profile (HP:0003642)2.67252996
32Aplasia/Hypoplasia of the sacrum (HP:0008517)2.60686940
33Optic disc pallor (HP:0000543)2.58909548
34Increased muscle lipid content (HP:0009058)2.58441694
35Pallor (HP:0000980)2.57963758
36Abnormality of midbrain morphology (HP:0002418)2.47145006
37Molar tooth sign on MRI (HP:0002419)2.47145006
38Abnormality of methionine metabolism (HP:0010901)2.46175753
39Aplastic anemia (HP:0001915)2.40601068
40Congenital, generalized hypertrichosis (HP:0004540)2.39051083
41Stenosis of the external auditory canal (HP:0000402)2.37354821
42Lethargy (HP:0001254)2.34376570
43Increased serum pyruvate (HP:0003542)2.32990137
44Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.32327582
45Glycosuria (HP:0003076)2.31961280
46Abnormality of urine glucose concentration (HP:0011016)2.31961280
47Methylmalonic aciduria (HP:0012120)2.29228776
48Pancreatic cysts (HP:0001737)2.28688083
49Generalized aminoaciduria (HP:0002909)2.26559075
50Pancreatic fibrosis (HP:0100732)2.20552881
51Amniotic constriction ring (HP:0009775)2.17936555
52Abnormality of placental membranes (HP:0011409)2.17936555
53Meckel diverticulum (HP:0002245)2.15871157
54Abnormality of aspartate family amino acid metabolism (HP:0010899)2.14750427
55Absent thumb (HP:0009777)2.14540585
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.13603812
57Abnormal protein N-linked glycosylation (HP:0012347)2.13603812
58Abnormal protein glycosylation (HP:0012346)2.13603812
59Abnormal glycosylation (HP:0012345)2.13603812
60Hypoplastic pelvis (HP:0008839)2.08863438
61X-linked dominant inheritance (HP:0001423)2.07822309
62Oral leukoplakia (HP:0002745)2.07546949
63Degeneration of anterior horn cells (HP:0002398)2.06849231
64Abnormality of the anterior horn cell (HP:0006802)2.06849231
65Abnormality of the ileum (HP:0001549)2.05364356
66Hyperphosphaturia (HP:0003109)2.04893727
67Septo-optic dysplasia (HP:0100842)2.04578627
68CNS demyelination (HP:0007305)2.02561239
69True hermaphroditism (HP:0010459)2.02357213
70Reduced antithrombin III activity (HP:0001976)2.01868446
71Abnormality of glycolysis (HP:0004366)2.00157392
72Aplasia/Hypoplasia of the uvula (HP:0010293)1.99860893
73Abnormality of the labia minora (HP:0012880)1.99606227
74Abnormality of alanine metabolism (HP:0010916)1.99018657
75Hyperalaninemia (HP:0003348)1.99018657
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99018657
77Medial flaring of the eyebrow (HP:0010747)1.98572732
78Sparse eyelashes (HP:0000653)1.95271155
79Megaloblastic anemia (HP:0001889)1.94174933
80Microvesicular hepatic steatosis (HP:0001414)1.92954909
81Abnormality of the preputium (HP:0100587)1.91895990
82Cleft eyelid (HP:0000625)1.89243018
83Abnormality of serum amino acid levels (HP:0003112)1.88880923
84Absent septum pellucidum (HP:0001331)1.84846614
85Pancytopenia (HP:0001876)1.83270128
86Supernumerary spleens (HP:0009799)1.82454826
87Abnormality of chromosome stability (HP:0003220)1.81570572
88Abnormal lung lobation (HP:0002101)1.80918756
89Hyperglycinemia (HP:0002154)1.80533220
90Nephronophthisis (HP:0000090)1.76909316
91Birth length less than 3rd percentile (HP:0003561)1.76689920
92Triphalangeal thumb (HP:0001199)1.76610887
93Colon cancer (HP:0003003)1.74948625
94Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.74489498
95Median cleft lip (HP:0000161)1.73867056
96Sclerocornea (HP:0000647)1.72510862
97Testicular atrophy (HP:0000029)1.67059788
98Abnormality of aromatic amino acid family metabolism (HP:0004338)1.66403160
99Abnormality of the septum pellucidum (HP:0007375)1.65703584
100Cerebral hypomyelination (HP:0006808)1.62769996

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.48488641
2BUB13.93273834
3STK163.41120963
4CDC72.88823130
5MST42.82198575
6SRPK12.67998333
7NEK12.62277636
8PBK2.55520973
9EIF2AK12.52847954
10VRK12.52050645
11ZAK2.47638280
12NME12.31531505
13MAP3K122.18488529
14NME22.14495779
15NUAK12.06875103
16PLK31.96068062
17EIF2AK31.95395101
18TTK1.91464158
19PLK41.82884885
20PDK21.73442588
21BMPR1B1.68442225
22TRIM281.65576396
23TLK11.51090823
24WEE11.50467739
25PLK11.48861707
26MAP4K21.47041024
27BRSK21.37692017
28WNK31.31816997
29TAF11.31738799
30AURKB1.24434092
31ARAF1.18826556
32AURKA1.14911772
33BCKDK1.14343058
34TSSK61.10396198
35CCNB11.08540318
36DYRK21.07165842
37BRSK11.07000034
38LIMK10.93509604
39CSNK1G30.91062942
40CHEK20.90204958
41PNCK0.88411318
42GRK10.87113079
43PLK20.85133336
44MKNK10.82724363
45CSNK1G10.82374309
46INSRR0.82065040
47NEK20.81676418
48MKNK20.80001728
49ATR0.79638225
50CSNK2A20.78846818
51CDK80.78733662
52ADRBK20.78564330
53PIM20.77508863
54PASK0.75814245
55MAP2K70.73300418
56CSNK2A10.73143862
57PRKCI0.72195852
58CSNK1G20.71386372
59EIF2AK20.70478187
60RPS6KB20.69846440
61PAK40.69464597
62ABL20.68845850
63DYRK30.66730112
64BRAF0.66435767
65TNIK0.63125997
66TIE10.62753581
67MYLK0.61087463
68ILK0.60764614
69CHEK10.60048131
70MAP3K40.59491816
71CDK190.58829675
72CSNK1A1L0.58607145
73STK40.57831706
74MUSK0.57255809
75CDK70.56609947
76TESK20.55281885
77CSNK1E0.53636078
78OXSR10.52208903
79RPS6KA50.50188195
80STK38L0.48491559
81ERBB40.47899329
82PRKCG0.46564759
83ATM0.46225689
84EPHB20.45581277
85STK390.45063242
86WNK40.44248630
87CDK90.42937435
88DAPK30.40848762
89TESK10.40215877
90DAPK10.38868394
91STK30.36559002
92BCR0.34701130
93MAPKAPK50.34273937
94ERBB30.34251616
95TGFBR10.33852285
96FRK0.33642013
97STK240.32192488
98ACVR1B0.32174279
99CDK10.31761183
100PAK10.31504035

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030105.04969805
2Oxidative phosphorylation_Homo sapiens_hsa001904.36577044
3Proteasome_Homo sapiens_hsa030504.15687380
4Parkinsons disease_Homo sapiens_hsa050123.68909346
5Protein export_Homo sapiens_hsa030603.13374668
6RNA polymerase_Homo sapiens_hsa030202.91642649
7Mismatch repair_Homo sapiens_hsa034302.90382734
8DNA replication_Homo sapiens_hsa030302.78491187
9Huntingtons disease_Homo sapiens_hsa050162.75211460
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.53100723
11Homologous recombination_Homo sapiens_hsa034402.49974866
12Alzheimers disease_Homo sapiens_hsa050102.48176589
13Nucleotide excision repair_Homo sapiens_hsa034202.20606787
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.17857298
15Spliceosome_Homo sapiens_hsa030402.02457518
16Basal transcription factors_Homo sapiens_hsa030221.99885188
17Pyrimidine metabolism_Homo sapiens_hsa002401.75108648
18Base excision repair_Homo sapiens_hsa034101.71446820
19Cardiac muscle contraction_Homo sapiens_hsa042601.71075246
20Fanconi anemia pathway_Homo sapiens_hsa034601.68915745
21RNA transport_Homo sapiens_hsa030131.65202124
22One carbon pool by folate_Homo sapiens_hsa006701.58545838
23RNA degradation_Homo sapiens_hsa030181.57509209
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56904613
25Folate biosynthesis_Homo sapiens_hsa007901.56223510
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38571877
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28046447
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19790936
29Non-homologous end-joining_Homo sapiens_hsa034501.17314998
30Purine metabolism_Homo sapiens_hsa002301.15871786
31Cell cycle_Homo sapiens_hsa041101.15564847
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13903978
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10525431
34Propanoate metabolism_Homo sapiens_hsa006401.10005764
35Fatty acid elongation_Homo sapiens_hsa000621.01905656
36Pyruvate metabolism_Homo sapiens_hsa006201.01426254
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00699804
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00010083
39Glutathione metabolism_Homo sapiens_hsa004800.98695163
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98207619
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.96554255
42Drug metabolism - other enzymes_Homo sapiens_hsa009830.90623086
43Sulfur relay system_Homo sapiens_hsa041220.90080304
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87662876
45Sulfur metabolism_Homo sapiens_hsa009200.82753679
46Collecting duct acid secretion_Homo sapiens_hsa049660.82059366
47Metabolic pathways_Homo sapiens_hsa011000.81816602
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79062236
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77915114
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76004384
51Steroid biosynthesis_Homo sapiens_hsa001000.75013200
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73184079
53Selenocompound metabolism_Homo sapiens_hsa004500.72773721
54Vitamin B6 metabolism_Homo sapiens_hsa007500.69966371
55Chemical carcinogenesis_Homo sapiens_hsa052040.68664438
56Caffeine metabolism_Homo sapiens_hsa002320.64166378
57Peroxisome_Homo sapiens_hsa041460.62013720
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61703527
59Oocyte meiosis_Homo sapiens_hsa041140.58395710
60Butanoate metabolism_Homo sapiens_hsa006500.57500859
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53962432
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.53598362
63mRNA surveillance pathway_Homo sapiens_hsa030150.53403916
64Regulation of autophagy_Homo sapiens_hsa041400.52532630
65p53 signaling pathway_Homo sapiens_hsa041150.49850524
66Carbon metabolism_Homo sapiens_hsa012000.49449218
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.49057617
68Retinol metabolism_Homo sapiens_hsa008300.47476758
69Phototransduction_Homo sapiens_hsa047440.43217971
70N-Glycan biosynthesis_Homo sapiens_hsa005100.41720403
71Tryptophan metabolism_Homo sapiens_hsa003800.39656655
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38988797
73Mineral absorption_Homo sapiens_hsa049780.35939624
74Biosynthesis of amino acids_Homo sapiens_hsa012300.32807368
75beta-Alanine metabolism_Homo sapiens_hsa004100.32301812
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31382949
77Vitamin digestion and absorption_Homo sapiens_hsa049770.31082706
78Arginine and proline metabolism_Homo sapiens_hsa003300.30765260
79Vibrio cholerae infection_Homo sapiens_hsa051100.29648255
80Tyrosine metabolism_Homo sapiens_hsa003500.29410060
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29094231
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28515307
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25446435
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23034709
85Fatty acid degradation_Homo sapiens_hsa000710.22830879
86Systemic lupus erythematosus_Homo sapiens_hsa053220.22606758
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22352244
88Epstein-Barr virus infection_Homo sapiens_hsa051690.22252573
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.20916024
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19021233
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.15922784
92Starch and sucrose metabolism_Homo sapiens_hsa005000.14733933
93Fatty acid metabolism_Homo sapiens_hsa012120.14145192
94Nitrogen metabolism_Homo sapiens_hsa009100.13231537
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.13174174
96Linoleic acid metabolism_Homo sapiens_hsa005910.12770530
97Basal cell carcinoma_Homo sapiens_hsa052170.12296964
98Hedgehog signaling pathway_Homo sapiens_hsa043400.11557276
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.11173185
100Arachidonic acid metabolism_Homo sapiens_hsa005900.08824073

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