ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.60572188
2	ribosomal small subunit assembly (GO:0000028)	6.37218714
3	cytidine metabolic process (GO:0046087)	5.51719337
4	cytidine catabolic process (GO:0006216)	5.51719337
5	cytidine deamination (GO:0009972)	5.51719337
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.30229589
7	ATP synthesis coupled proton transport (GO:0015986)	5.05361974
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.05361974
9	viral transcription (GO:0019083)	4.86965496
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.86166097
11	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.85865697
12	translational termination (GO:0006415)	4.67464163
13	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.64349854
14	maturation of SSU-rRNA (GO:0030490)	4.41769225
15	translational elongation (GO:0006414)	4.36244218
16	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.21279233
17	ribosomal small subunit biogenesis (GO:0042274)	4.20479451
18	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.09245969
19	ribosomal large subunit biogenesis (GO:0042273)	4.08082026
20	cotranslational protein targeting to membrane (GO:0006613)	4.02826380
21	protein targeting to ER (GO:0045047)	4.01353055
22	protein neddylation (GO:0045116)	3.97572773
23	iron-sulfur cluster assembly (GO:0016226)	3.90095110
24	metallo-sulfur cluster assembly (GO:0031163)	3.90095110
25	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.87359175
26	chaperone-mediated protein transport (GO:0072321)	3.84520982
27	respiratory electron transport chain (GO:0022904)	3.84334491
28	electron transport chain (GO:0022900)	3.84060760
29	protein localization to endoplasmic reticulum (GO:0070972)	3.80804315
30	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.78117822
31	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.56719364
32	behavioral response to nicotine (GO:0035095)	3.55871915
33	viral life cycle (GO:0019058)	3.51613921
34	cellular protein complex disassembly (GO:0043624)	3.49499014
35	protein complex biogenesis (GO:0070271)	3.46696531
36	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.44144386
37	water-soluble vitamin biosynthetic process (GO:0042364)	3.43652424
38	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.40293579
39	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.40293579
40	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.37499947
41	translational initiation (GO:0006413)	3.29003314
42	translation (GO:0006412)	3.28652568
43	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.24179900
44	ubiquinone biosynthetic process (GO:0006744)	3.19135538
45	negative regulation of mast cell activation (GO:0033004)	3.15398699
46	pyrimidine nucleotide catabolic process (GO:0006244)	3.08544213
47	mitochondrial respiratory chain complex assembly (GO:0033108)	3.07219379
48	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.05124578
49	NADH dehydrogenase complex assembly (GO:0010257)	3.05124578
50	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.05124578
51	actin nucleation (GO:0045010)	3.03110709
52	protein-cofactor linkage (GO:0018065)	3.03038036
53	rRNA modification (GO:0000154)	3.00852083
54	piRNA metabolic process (GO:0034587)	2.99881806
55	sequestering of actin monomers (GO:0042989)	2.99418801
56	ubiquinone metabolic process (GO:0006743)	2.93607475
57	ncRNA 3-end processing (GO:0043628)	2.93048858
58	positive regulation of calcium-mediated signaling (GO:0050850)	2.91932177
59	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.91453443
60	negative regulation by host of viral transcription (GO:0043922)	2.90325946
61	cellular component biogenesis (GO:0044085)	2.88670460
62	ribonucleoprotein complex biogenesis (GO:0022613)	2.86026489
63	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.84909981
64	protein complex disassembly (GO:0043241)	2.84389203
65	regulation of cellular amino acid metabolic process (GO:0006521)	2.82206835
66	respiratory chain complex IV assembly (GO:0008535)	2.77808967
67	cytochrome complex assembly (GO:0017004)	2.77332589
68	hydrogen ion transmembrane transport (GO:1902600)	2.76668591
69	cellular ketone body metabolic process (GO:0046950)	2.74547976
70	positive T cell selection (GO:0043368)	2.73988228
71	ATP biosynthetic process (GO:0006754)	2.73604220
72	macromolecular complex disassembly (GO:0032984)	2.73452056
73	regulation of activation of Janus kinase activity (GO:0010533)	2.72464010
74	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.68134257
75	pseudouridine synthesis (GO:0001522)	2.67704304
76	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.67219159
77	substrate-independent telencephalic tangential migration (GO:0021826)	2.67219159
78	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.65924274
79	proton transport (GO:0015992)	2.65385039
80	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.65170449
81	termination of RNA polymerase III transcription (GO:0006386)	2.64577378
82	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.64577378
83	mannosylation (GO:0097502)	2.64562870
84	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.63578644
85	interferon-gamma production (GO:0032609)	2.61350202
86	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.60384262
87	rRNA processing (GO:0006364)	2.60279436
88	hydrogen transport (GO:0006818)	2.60111377
89	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.59484829
90	deoxyribonucleotide catabolic process (GO:0009264)	2.58993395
91	quinone biosynthetic process (GO:1901663)	2.58476490
92	proteasome assembly (GO:0043248)	2.58318139
93	rRNA metabolic process (GO:0016072)	2.57521836
94	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.57326115
95	deoxyribose phosphate catabolic process (GO:0046386)	2.57025052
96	cytolysis (GO:0019835)	2.55078934
97	positive regulation of T cell apoptotic process (GO:0070234)	2.54765530
98	pyrimidine nucleoside catabolic process (GO:0046135)	2.54402152
99	base-excision repair, AP site formation (GO:0006285)	2.54380412
100	purine nucleotide salvage (GO:0032261)	2.54043801

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.94524102
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.59893780
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.56940125
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.26796887
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.09616669
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.07557461
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.88734614
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.85180042
9	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.78041044
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.76611537
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.72727135
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.63523703
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.58490054
14	VDR_22108803_ChIP-Seq_LS180_Human	2.57437956
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.42642278
16	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.41372188
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.40217402
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.39454597
19	ZNF274_21170338_ChIP-Seq_K562_Hela	2.33617141
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.14904734
21	FOXP3_21729870_ChIP-Seq_TREG_Human	1.96703109
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.90008972
23	IRF1_19129219_ChIP-ChIP_H3396_Human	1.82679407
24	ELK1_19687146_ChIP-ChIP_HELA_Human	1.79232935
25	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.75165886
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.74833243
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.70891708
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.67699869
29	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.65323775
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.64038210
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.57048506
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.55898163
33	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.50550814
34	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.50322188
35	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.49152530
36	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.48498173
37	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44854638
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.40021044
39	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.39058749
40	EWS_26573619_Chip-Seq_HEK293_Human	1.36849469
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.35366048
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.35366048
43	AR_20517297_ChIP-Seq_VCAP_Human	1.34025549
44	MYB_26560356_Chip-Seq_TH2_Human	1.30095883
45	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.29017470
46	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.28888057
47	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.28443777
48	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.26259332
49	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.25688141
50	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.24701422
51	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.21991611
52	NCOR_22424771_ChIP-Seq_293T_Human	1.21483829
53	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.20707886
54	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.19230389
55	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.17668414
56	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.16881326
57	TAF2_19829295_ChIP-Seq_ESCs_Human	1.16344019
58	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.16244516
59	NANOG_20526341_ChIP-Seq_ESCs_Human	1.15558908
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.15259902
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.15259902
62	FUS_26573619_Chip-Seq_HEK293_Human	1.14109830
63	GATA3_26560356_Chip-Seq_TH2_Human	1.13860441
64	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.11010006
65	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10525967
66	ERG_20517297_ChIP-Seq_VCAP_Human	1.10428865
67	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08588910
68	ER_23166858_ChIP-Seq_MCF-7_Human	1.08067359
69	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.07091180
70	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05897992
71	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.03988587
72	TTF2_22483619_ChIP-Seq_HELA_Human	1.03891231
73	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02261019
74	GABP_19822575_ChIP-Seq_HepG2_Human	1.02087539
75	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.00972120
76	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.00692622
77	HTT_18923047_ChIP-ChIP_STHdh_Human	1.00593978
78	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.98986348
79	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.98584479
80	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98326132
81	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.98096727
82	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.97929468
83	RNF2_27304074_Chip-Seq_NSC_Mouse	0.97870773
84	GATA3_27048872_Chip-Seq_THYMUS_Human	0.97446592
85	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96892480
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.96209347
87	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.95929235
88	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95783011
89	ERA_21632823_ChIP-Seq_H3396_Human	0.95455361
90	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.95097564
91	HOXB7_26014856_ChIP-Seq_BT474_Human	0.94361718
92	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.93769585
93	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.93625586
94	CBP_20019798_ChIP-Seq_JUKART_Human	0.93399701
95	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.93399701
96	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.92915689
97	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.92536094
98	MYC_19829295_ChIP-Seq_ESCs_Human	0.92248002
99	P300_19829295_ChIP-Seq_ESCs_Human	0.91815349
100	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.91696391

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	3.99606336
2	MP0005671_abnormal_response_to	3.58431641
3	MP0006292_abnormal_olfactory_placode	3.13949824
4	MP0006072_abnormal_retinal_apoptosis	2.27913061
5	MP0005084_abnormal_gallbladder_morpholo	2.25742667
6	MP0003646_muscle_fatigue	2.21843996
7	MP0005645_abnormal_hypothalamus_physiol	2.20243382
8	MP0008877_abnormal_DNA_methylation	2.10174862
9	MP0003880_abnormal_central_pattern	2.08903446
10	MP0004147_increased_porphyrin_level	2.06459259
11	MP0002102_abnormal_ear_morphology	2.05812391
12	MP0005646_abnormal_pituitary_gland	1.94503625
13	MP0009333_abnormal_splenocyte_physiolog	1.80550420
14	MP0001968_abnormal_touch/_nociception	1.79720513
15	MP0008995_early_reproductive_senescence	1.77787038
16	MP0002160_abnormal_reproductive_system	1.75293275
17	MP0009785_altered_susceptibility_to	1.74068038
18	MP0005551_abnormal_eye_electrophysiolog	1.71240079
19	MP0003763_abnormal_thymus_physiology	1.70354225
20	MP0006276_abnormal_autonomic_nervous	1.69569051
21	MP0005389_reproductive_system_phenotype	1.66821762
22	MP0001835_abnormal_antigen_presentation	1.63975707
23	MP0001905_abnormal_dopamine_level	1.59156895
24	MP0003806_abnormal_nucleotide_metabolis	1.58766569
25	MP0002148_abnormal_hypersensitivity_rea	1.57215619
26	MP0002736_abnormal_nociception_after	1.56943823
27	MP0008875_abnormal_xenobiotic_pharmacok	1.56393746
28	MP0002638_abnormal_pupillary_reflex	1.52886687
29	MP0001800_abnormal_humoral_immune	1.51854720
30	MP0002837_dystrophic_cardiac_calcinosis	1.51049544
31	MP0002138_abnormal_hepatobiliary_system	1.43796307
32	MP0000372_irregular_coat_pigmentation	1.40682797
33	MP0004145_abnormal_muscle_electrophysio	1.40626136
34	MP0001919_abnormal_reproductive_system	1.39846491
35	MP0004142_abnormal_muscle_tone	1.33434420
36	MP0008789_abnormal_olfactory_epithelium	1.32586192
37	MP0005253_abnormal_eye_physiology	1.31747377
38	MP0005000_abnormal_immune_tolerance	1.31672688
39	MP0008872_abnormal_physiological_respon	1.29657800
40	MP0001485_abnormal_pinna_reflex	1.29332122
41	MP0003786_premature_aging	1.26160144
42	MP0005377_hearing/vestibular/ear_phenot	1.23935310
43	MP0003878_abnormal_ear_physiology	1.23935310
44	MP0002723_abnormal_immune_serum	1.22921222
45	MP0002163_abnormal_gland_morphology	1.22093287
46	MP0001986_abnormal_taste_sensitivity	1.21819657
47	MP0002095_abnormal_skin_pigmentation	1.20989214
48	MP0002420_abnormal_adaptive_immunity	1.19150461
49	MP0003787_abnormal_imprinting	1.17839333
50	MP0001819_abnormal_immune_cell	1.16483809
51	MP0002822_catalepsy	1.15553660
52	MP0002272_abnormal_nervous_system	1.13304407
53	MP0002876_abnormal_thyroid_physiology	1.11800459
54	MP0009764_decreased_sensitivity_to	1.11284501
55	MP0001188_hyperpigmentation	1.08735981
56	MP0002653_abnormal_ependyma_morphology	1.08345673
57	MP0001764_abnormal_homeostasis	1.07983778
58	MP0008058_abnormal_DNA_repair	1.06644508
59	MP0004885_abnormal_endolymph	1.06365130
60	MP0001790_abnormal_immune_system	1.06227256
61	MP0005387_immune_system_phenotype	1.06227256
62	MP0001529_abnormal_vocalization	1.05197845
63	MP0005025_abnormal_response_to	1.04885354
64	MP0002735_abnormal_chemical_nociception	1.04742104
65	MP0003567_abnormal_fetal_cardiomyocyte	1.04716875
66	MP0002234_abnormal_pharynx_morphology	1.04258767
67	MP0005195_abnormal_posterior_eye	1.03706924
68	MP0002733_abnormal_thermal_nociception	1.03666244
69	MP0002277_abnormal_respiratory_mucosa	1.01556162
70	MP0002452_abnormal_antigen_presenting	1.00409116
71	MP0005075_abnormal_melanosome_morpholog	0.98494520
72	MP0003866_abnormal_defecation	0.98487286
73	MP0002166_altered_tumor_susceptibility	0.97564635
74	MP0006036_abnormal_mitochondrial_physio	0.96518792
75	MP0001970_abnormal_pain_threshold	0.96117153
76	MP0002006_tumorigenesis	0.94941148
77	MP0004742_abnormal_vestibular_system	0.94913514
78	MP0000631_abnormal_neuroendocrine_gland	0.92901599
79	MP0003693_abnormal_embryo_hatching	0.92016865
80	MP0000049_abnormal_middle_ear	0.88822282
81	MP0009745_abnormal_behavioral_response	0.87837689
82	MP0005410_abnormal_fertilization	0.85175254
83	MP0002752_abnormal_somatic_nervous	0.84700872
84	MP0000716_abnormal_immune_system	0.84647008
85	MP0005394_taste/olfaction_phenotype	0.82005803
86	MP0005499_abnormal_olfactory_system	0.82005803
87	MP0002210_abnormal_sex_determination	0.80019357
88	MP0000685_abnormal_immune_system	0.79947802
89	MP0002398_abnormal_bone_marrow	0.78379907
90	MP0005379_endocrine/exocrine_gland_phen	0.77475558
91	MP0001963_abnormal_hearing_physiology	0.75698710
92	MP0001873_stomach_inflammation	0.73748515
93	MP0005636_abnormal_mineral_homeostasis	0.73589200
94	MP0001486_abnormal_startle_reflex	0.72855379
95	MP0006035_abnormal_mitochondrial_morpho	0.72109319
96	MP0001984_abnormal_olfaction	0.70125466
97	MP0000703_abnormal_thymus_morphology	0.69926880
98	MP0002557_abnormal_social/conspecific_i	0.69649870
99	MP0000689_abnormal_spleen_morphology	0.68652322
100	MP0001293_anophthalmia	0.68127434

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.42481034
2	Abnormal mitochondria in muscle tissue (HP:0008316)	3.99202104
3	Mitochondrial inheritance (HP:0001427)	3.90958415
4	Acute encephalopathy (HP:0006846)	3.76714850
5	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.63508566
6	Progressive macrocephaly (HP:0004481)	3.60620199
7	Increased CSF lactate (HP:0002490)	3.56940176
8	Congenital stationary night blindness (HP:0007642)	3.48316400
9	Elevated erythrocyte sedimentation rate (HP:0003565)	3.32770086
10	3-Methylglutaconic aciduria (HP:0003535)	3.16741791
11	IgG deficiency (HP:0004315)	3.11586737
12	Reticulocytopenia (HP:0001896)	3.10744655
13	Abnormality of cells of the erythroid lineage (HP:0012130)	3.08634356
14	Severe combined immunodeficiency (HP:0004430)	3.06528656
15	Hepatocellular necrosis (HP:0001404)	3.05675606
16	Abolished electroretinogram (ERG) (HP:0000550)	2.94275955
17	Abnormal rod and cone electroretinograms (HP:0008323)	2.92848368
18	Cerebral edema (HP:0002181)	2.87386283
19	Pancreatic fibrosis (HP:0100732)	2.82356925
20	Pancreatic cysts (HP:0001737)	2.81456035
21	Aplastic anemia (HP:0001915)	2.81046643
22	Abnormality of B cell number (HP:0010975)	2.77224530
23	Abnormality of midbrain morphology (HP:0002418)	2.72364981
24	Molar tooth sign on MRI (HP:0002419)	2.72364981
25	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.68453528
26	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.68453528
27	Hepatic necrosis (HP:0002605)	2.68048999
28	Increased intramyocellular lipid droplets (HP:0012240)	2.67624145
29	Increased hepatocellular lipid droplets (HP:0006565)	2.67528867
30	Increased IgM level (HP:0003496)	2.66544117
31	True hermaphroditism (HP:0010459)	2.64073740
32	Macrocytic anemia (HP:0001972)	2.60422384
33	Stomatitis (HP:0010280)	2.58486620
34	B lymphocytopenia (HP:0010976)	2.57111602
35	Hypoproteinemia (HP:0003075)	2.56868826
36	Type II lissencephaly (HP:0007260)	2.54887420
37	Increased serum lactate (HP:0002151)	2.51467066
38	Type 2 muscle fiber atrophy (HP:0003554)	2.50694344
39	Pendular nystagmus (HP:0012043)	2.49942644
40	Optic disc pallor (HP:0000543)	2.47847963
41	Hyperglycinemia (HP:0002154)	2.44611136
42	Abnormal number of erythroid precursors (HP:0012131)	2.43839241
43	Methylmalonic acidemia (HP:0002912)	2.43636820
44	Renal cortical cysts (HP:0000803)	2.42884632
45	Decreased central vision (HP:0007663)	2.40347262
46	Lipid accumulation in hepatocytes (HP:0006561)	2.39262793
47	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.37797610
48	Lactic acidosis (HP:0003128)	2.34414186
49	Autoimmune hemolytic anemia (HP:0001890)	2.34167825
50	Nephronophthisis (HP:0000090)	2.32371245
51	Attenuation of retinal blood vessels (HP:0007843)	2.31492611
52	Abnormality of the renal cortex (HP:0011035)	2.30530255
53	Abnormality of alanine metabolism (HP:0010916)	2.30026926
54	Hyperalaninemia (HP:0003348)	2.30026926
55	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.30026926
56	Lethargy (HP:0001254)	2.27118688
57	Absent thumb (HP:0009777)	2.26497222
58	Combined immunodeficiency (HP:0005387)	2.25330083
59	Abnormal drinking behavior (HP:0030082)	2.23395304
60	Polydipsia (HP:0001959)	2.23395304
61	Medial flaring of the eyebrow (HP:0010747)	2.21437099
62	Renal Fanconi syndrome (HP:0001994)	2.19224905
63	Methylmalonic aciduria (HP:0012120)	2.19193861
64	Constricted visual fields (HP:0001133)	2.16835843
65	Abnormality of DNA repair (HP:0003254)	2.16718966
66	Thyroiditis (HP:0100646)	2.16583834
67	Increased muscle lipid content (HP:0009058)	2.13311523
68	Abnormality of T cell number (HP:0011839)	2.12710660
69	Abnormality of the prostate (HP:0008775)	2.11209655
70	T lymphocytopenia (HP:0005403)	2.09991150
71	Stenosis of the external auditory canal (HP:0000402)	2.09551822
72	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.09466251
73	Hypoplasia of the uterus (HP:0000013)	2.07349605
74	Muscle fiber atrophy (HP:0100295)	2.05662521
75	Autoimmune thrombocytopenia (HP:0001973)	2.01510064
76	Pancytopenia (HP:0001876)	2.01335688
77	Asplenia (HP:0001746)	1.99282108
78	Respiratory failure (HP:0002878)	1.95648982
79	Abnormality of T cells (HP:0002843)	1.95561061
80	Decreased circulating renin level (HP:0003351)	1.93866477
81	Aplasia/hypoplasia of the uterus (HP:0008684)	1.92100627
82	Pallor (HP:0000980)	1.90215985
83	Panhypogammaglobulinemia (HP:0003139)	1.89772925
84	Type I transferrin isoform profile (HP:0003642)	1.88769988
85	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.87623655
86	Leukodystrophy (HP:0002415)	1.84962016
87	Abnormality of eosinophils (HP:0001879)	1.82678261
88	Abnormality of the renal medulla (HP:0100957)	1.82510250
89	Dicarboxylic aciduria (HP:0003215)	1.76629712
90	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.76629712
91	Reduced antithrombin III activity (HP:0001976)	1.76506353
92	Polyuria (HP:0000103)	1.75778202
93	Ketosis (HP:0001946)	1.75219057
94	Increased corneal curvature (HP:0100692)	1.74709902
95	Keratoconus (HP:0000563)	1.74709902
96	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.74374520
97	Abnormality of serum amino acid levels (HP:0003112)	1.72979219
98	Cerebellar dysplasia (HP:0007033)	1.72865124
99	Absent/shortened dynein arms (HP:0200106)	1.72166494
100	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.72166494

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	KDR	3.91555066
2	BCKDK	3.52855263
3	TXK	3.19850640
4	CDK19	3.17571595
5	ZAK	3.04666451
6	TESK2	2.98807709
7	VRK2	2.93217952
8	TAOK3	2.69995147
9	MAP4K2	2.66316238
10	NUAK1	2.63380289
11	ADRBK2	2.59220451
12	STK16	2.57216621
13	WNK4	2.39455526
14	VRK1	1.99820482
15	GRK1	1.97993293
16	TLK1	1.88172229
17	MAP4K1	1.75257848
18	SCYL2	1.73287453
19	ITK	1.57879172
20	TIE1	1.51064235
21	TEC	1.44248637
22	CAMKK2	1.39811595
23	PIK3CA	1.36402764
24	SYK	1.22774179
25	PLK4	1.21717128
26	LIMK1	1.17632552
27	FRK	1.16826102
28	RPS6KA5	1.13937652
29	GRK6	1.10058250
30	OXSR1	1.09307956
31	PRKCQ	1.09208856
32	STK39	1.05958486
33	MAP3K12	1.04733898
34	DYRK2	1.04063164
35	INSRR	1.00830056
36	BTK	0.99738002
37	MUSK	0.99024166
38	MAPKAPK5	0.95035001
39	TESK1	0.94455334
40	NME2	0.93553800
41	EIF2AK3	0.89452515
42	FES	0.86368727
43	IKBKB	0.85737314
44	MAP3K11	0.82587231
45	PIK3CG	0.76381685
46	PINK1	0.74673014
47	BRSK2	0.74338807
48	PASK	0.72604747
49	KIT	0.70278079
50	WNK3	0.67543518
51	IKBKE	0.64574207
52	CSF1R	0.64535004
53	LYN	0.64307621
54	PDK2	0.63249356
55	CSNK1G3	0.63122087
56	ADRBK1	0.63016833
57	LCK	0.62986483
58	TNK2	0.62922140
59	MAPK13	0.62720934
60	MYLK	0.62183503
61	MAP2K7	0.61810537
62	AURKA	0.59892508
63	NME1	0.59426174
64	ARAF	0.58937916
65	GRK7	0.57339106
66	OBSCN	0.54489570
67	PIM2	0.54390201
68	DAPK1	0.53410965
69	PRKACA	0.51150184
70	AURKB	0.50877223
71	CSNK1G2	0.50322218
72	PRKCG	0.50092310
73	DAPK3	0.47771807
74	TRIM28	0.45733570
75	DAPK2	0.45217424
76	NEK1	0.45152684
77	CAMKK1	0.44390363
78	PIM1	0.44169669
79	CSNK1G1	0.43262844
80	PRKCA	0.42571573
81	CSNK2A2	0.42495225
82	BMPR1B	0.42009774
83	MKNK1	0.41294995
84	CSNK2A1	0.41055206
85	EPHA4	0.40687624
86	GRK5	0.37415833
87	IGF1R	0.37160828
88	BRSK1	0.36732650
89	MST4	0.35966265
90	CSNK1A1L	0.35147489
91	LRRK2	0.32678436
92	CAMK2A	0.32572828
93	TBK1	0.31470805
94	PRKCD	0.31329439
95	CAMK1	0.30715578
96	PRKCE	0.30182573
97	CSK	0.29616620
98	MAP2K6	0.28929305
99	PLK1	0.28542308
100	MAPK15	0.27708175

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.53997868
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.87944307
3	Proteasome_Homo sapiens_hsa03050	3.59105025
4	Primary immunodeficiency_Homo sapiens_hsa05340	3.52665309
5	Parkinsons disease_Homo sapiens_hsa05012	3.31183219
6	RNA polymerase_Homo sapiens_hsa03020	2.31910238
7	Alzheimers disease_Homo sapiens_hsa05010	2.14733358
8	Allograft rejection_Homo sapiens_hsa05330	2.14497421
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.12583996
10	Huntingtons disease_Homo sapiens_hsa05016	2.05752848
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.04957245
12	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.01356941
13	Cardiac muscle contraction_Homo sapiens_hsa04260	1.97200058
14	Phototransduction_Homo sapiens_hsa04744	1.97114960
15	Asthma_Homo sapiens_hsa05310	1.96445629
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.92335260
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.87223603
18	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.81847324
19	Protein export_Homo sapiens_hsa03060	1.78129140
20	Antigen processing and presentation_Homo sapiens_hsa04612	1.75681190
21	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.68120420
22	Homologous recombination_Homo sapiens_hsa03440	1.66916727
23	Type I diabetes mellitus_Homo sapiens_hsa04940	1.66512466
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.62588926
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.46548642
26	RNA degradation_Homo sapiens_hsa03018	1.44876269
27	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.42511309
28	Linoleic acid metabolism_Homo sapiens_hsa00591	1.34490560
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.32679463
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.28880968
31	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.20538549
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.19224527
33	Rheumatoid arthritis_Homo sapiens_hsa05323	1.14022398
34	Butanoate metabolism_Homo sapiens_hsa00650	1.13404915
35	Sulfur relay system_Homo sapiens_hsa04122	1.12356207
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.12280664
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.09508567
38	Propanoate metabolism_Homo sapiens_hsa00640	1.09283043
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.08049825
40	Peroxisome_Homo sapiens_hsa04146	1.07344910
41	Purine metabolism_Homo sapiens_hsa00230	1.06024210
42	DNA replication_Homo sapiens_hsa03030	1.01185573
43	One carbon pool by folate_Homo sapiens_hsa00670	0.99996632
44	Mismatch repair_Homo sapiens_hsa03430	0.97786236
45	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.97358760
46	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.91345993
47	Basal transcription factors_Homo sapiens_hsa03022	0.89678501
48	Spliceosome_Homo sapiens_hsa03040	0.89280119
49	Olfactory transduction_Homo sapiens_hsa04740	0.85114656
50	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.83481305
51	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.83070302
52	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.82895015
53	Base excision repair_Homo sapiens_hsa03410	0.79319452
54	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.79280984
55	Nitrogen metabolism_Homo sapiens_hsa00910	0.79024609
56	Retinol metabolism_Homo sapiens_hsa00830	0.77928471
57	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.75833830
58	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.75216107
59	RNA transport_Homo sapiens_hsa03013	0.74488545
60	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.72831820
61	Caffeine metabolism_Homo sapiens_hsa00232	0.71954580
62	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71474742
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69063925
64	Ether lipid metabolism_Homo sapiens_hsa00565	0.64352254
65	Viral myocarditis_Homo sapiens_hsa05416	0.62450008
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.61785479
67	Tryptophan metabolism_Homo sapiens_hsa00380	0.60646096
68	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.60425394
69	Nicotine addiction_Homo sapiens_hsa05033	0.59866011
70	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.59750393
71	Metabolic pathways_Homo sapiens_hsa01100	0.59581164
72	Taste transduction_Homo sapiens_hsa04742	0.58870205
73	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.58469496
74	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.58424058
75	Regulation of autophagy_Homo sapiens_hsa04140	0.56178092
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.53006428
77	Collecting duct acid secretion_Homo sapiens_hsa04966	0.52749528
78	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.51019988
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.47704188
80	Selenocompound metabolism_Homo sapiens_hsa00450	0.43712828
81	Fat digestion and absorption_Homo sapiens_hsa04975	0.42186931
82	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.41891879
83	Alcoholism_Homo sapiens_hsa05034	0.39091617
84	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.38680454
85	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.37811815
86	Non-homologous end-joining_Homo sapiens_hsa03450	0.32347876
87	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.30931633
88	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.26568572
89	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.26278888
90	Malaria_Homo sapiens_hsa05144	0.25901932
91	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.24988933
92	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.24359792
93	Salivary secretion_Homo sapiens_hsa04970	0.24033185
94	Morphine addiction_Homo sapiens_hsa05032	0.24015880
95	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.21560988
96	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.20254551
97	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.20135601
98	Serotonergic synapse_Homo sapiens_hsa04726	0.18943173
99	ABC transporters_Homo sapiens_hsa02010	0.18718116
100	Fatty acid elongation_Homo sapiens_hsa00062	0.17850568

RPL26P19

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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