ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	7.51933120
2	maturation of SSU-rRNA (GO:0030490)	7.28205124
3	translational termination (GO:0006415)	7.14711468
4	ribosomal small subunit assembly (GO:0000028)	6.95519370
5	ribosomal small subunit biogenesis (GO:0042274)	6.90480896
6	behavioral response to nicotine (GO:0035095)	6.29643794
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.08476838
8	cotranslational protein targeting to membrane (GO:0006613)	6.07466270
9	protein targeting to ER (GO:0045047)	6.01975927
10	translational elongation (GO:0006414)	5.93885319
11	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.77433213
12	protein localization to endoplasmic reticulum (GO:0070972)	5.66185178
13	viral life cycle (GO:0019058)	5.48422304
14	cellular protein complex disassembly (GO:0043624)	5.42041832
15	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.20694410
16	protein complex disassembly (GO:0043241)	4.64960817
17	translational initiation (GO:0006413)	4.64074111
18	macromolecular complex disassembly (GO:0032984)	4.46565428
19	cardiovascular system development (GO:0072358)	4.18797602
20	ribosomal large subunit biogenesis (GO:0042273)	4.12480831
21	protein targeting to membrane (GO:0006612)	4.10208981
22	glycerophospholipid catabolic process (GO:0046475)	3.97063294
23	pattern specification involved in kidney development (GO:0061004)	3.82421181
24	body morphogenesis (GO:0010171)	3.72234072
25	tongue development (GO:0043586)	3.71102301
26	cell proliferation in forebrain (GO:0021846)	3.65787580
27	chaperone-mediated protein transport (GO:0072321)	3.62295184
28	ribonucleoprotein complex biogenesis (GO:0022613)	3.58636565
29	nephron tubule morphogenesis (GO:0072078)	3.58392894
30	nephron epithelium morphogenesis (GO:0072088)	3.58392894
31	microtubule severing (GO:0051013)	3.54613993
32	cellular component biogenesis (GO:0044085)	3.48471046
33	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.48394805
34	postsynaptic membrane organization (GO:0001941)	3.44977840
35	spinal cord association neuron differentiation (GO:0021527)	3.44754311
36	resolution of meiotic recombination intermediates (GO:0000712)	3.40755914
37	synaptic transmission, cholinergic (GO:0007271)	3.36071480
38	auditory receptor cell differentiation (GO:0042491)	3.35885516
39	neuron fate determination (GO:0048664)	3.35481130
40	translation (GO:0006412)	3.33984103
41	mRNA catabolic process (GO:0006402)	3.32308822
42	protein complex biogenesis (GO:0070271)	3.29617176
43	protein polyglutamylation (GO:0018095)	3.27946228
44	protein neddylation (GO:0045116)	3.25421081
45	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.25150173
46	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.25150173
47	NADH dehydrogenase complex assembly (GO:0010257)	3.25150173
48	negative regulation of telomere maintenance (GO:0032205)	3.24521680
49	axonal fasciculation (GO:0007413)	3.21664194
50	regulation of glycogen (starch) synthase activity (GO:2000465)	3.18042683
51	piRNA metabolic process (GO:0034587)	3.14104194
52	head development (GO:0060322)	3.13360233
53	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.10482956
54	ATP synthesis coupled proton transport (GO:0015986)	3.10482956
55	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.08484379
56	somite development (GO:0061053)	3.07471996
57	substrate-independent telencephalic tangential migration (GO:0021826)	3.06362237
58	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.06362237
59	parturition (GO:0007567)	3.04318575
60	pyrimidine nucleobase catabolic process (GO:0006208)	3.03876167
61	embryonic body morphogenesis (GO:0010172)	3.02613820
62	genetic imprinting (GO:0071514)	3.01525784
63	positive regulation of growth hormone secretion (GO:0060124)	2.97478684
64	epithelial cilium movement (GO:0003351)	2.97273206
65	RNA catabolic process (GO:0006401)	2.96723454
66	renal tubule morphogenesis (GO:0061333)	2.96363755
67	regulation of telomerase activity (GO:0051972)	2.88691734
68	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.88576594
69	mitochondrial respiratory chain complex assembly (GO:0033108)	2.86258027
70	establishment of mitochondrion localization (GO:0051654)	2.83578750
71	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.82066541
72	hypothalamus development (GO:0021854)	2.81220004
73	positive regulation of respiratory burst (GO:0060267)	2.78065041
74	dendritic spine morphogenesis (GO:0060997)	2.76085124
75	establishment of protein localization to membrane (GO:0090150)	2.69479069
76	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.67817727
77	mitochondrion transport along microtubule (GO:0047497)	2.67817727
78	protein localization to cilium (GO:0061512)	2.65601693
79	central nervous system myelination (GO:0022010)	2.62115611
80	axon ensheathment in central nervous system (GO:0032291)	2.62115611
81	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	2.60581241
82	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.59931442
83	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.57955764
84	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.57661324
85	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.56973154
86	intraciliary transport (GO:0042073)	2.56942659
87	cellular response to interferon-beta (GO:0035458)	2.56840449
88	regulation of telomere maintenance via telomerase (GO:0032210)	2.56054936
89	protein targeting (GO:0006605)	2.55452123
90	water-soluble vitamin biosynthetic process (GO:0042364)	2.55408790
91	phosphatidylcholine acyl-chain remodeling (GO:0036151)	2.54385254
92	regulation of cellular respiration (GO:0043457)	2.53988709
93	pituitary gland development (GO:0021983)	2.53969729
94	rRNA catabolic process (GO:0016075)	2.53127344
95	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.51336667
96	peptidyl-histidine modification (GO:0018202)	2.50296675
97	neuron recognition (GO:0008038)	2.50216935
98	respiratory electron transport chain (GO:0022904)	2.48596289
99	cell differentiation in spinal cord (GO:0021515)	2.47489771
100	electron transport chain (GO:0022900)	2.47237798

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.47906365
2	RBPJ_22232070_ChIP-Seq_NCS_Mouse	4.03308027
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.04598302
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.83509490
5	VDR_22108803_ChIP-Seq_LS180_Human	2.50919179
6	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.44638034
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.20512358
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.19989022
9	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.14373897
10	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.13822147
11	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.09204685
12	REST_21632747_ChIP-Seq_MESCs_Mouse	2.06915964
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.93606311
14	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.90288241
15	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.89929947
16	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.86574007
17	ZNF274_21170338_ChIP-Seq_K562_Hela	1.85505008
18	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.85105055
19	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.79659119
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.68920977
21	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.57949184
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.55731859
23	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.54462314
24	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.54462314
25	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.54196858
26	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.53938166
27	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.52925283
28	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.52771091
29	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.49967408
30	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.49925947
31	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.49906585
32	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.49906585
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.49794540
34	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.42397665
35	RNF2_27304074_Chip-Seq_NSC_Mouse	1.40990348
36	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.34117648
37	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.33090551
38	GBX2_23144817_ChIP-Seq_PC3_Human	1.31667970
39	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.30833245
40	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.29527747
41	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.28836970
42	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.28631395
43	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28483244
44	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.28321141
45	FUS_26573619_Chip-Seq_HEK293_Human	1.26225842
46	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.26138707
47	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.25611499
48	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.25129571
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.23310337
50	EWS_26573619_Chip-Seq_HEK293_Human	1.21660309
51	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.21333247
52	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.19637714
53	MYC_18940864_ChIP-ChIP_HL60_Human	1.18091213
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.17969834
55	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.15536149
56	P300_19829295_ChIP-Seq_ESCs_Human	1.12041497
57	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.11093423
58	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.11050560
59	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.10682188
60	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.10600578
61	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.10180997
62	CTCF_27219007_Chip-Seq_Bcells_Human	1.09972945
63	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.09384670
64	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.06813190
65	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.05705664
66	MYC_19829295_ChIP-Seq_ESCs_Human	1.05619718
67	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05072509
68	IRF1_19129219_ChIP-ChIP_H3396_Human	1.02962540
69	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.02861957
70	NANOG_20526341_ChIP-Seq_ESCs_Human	1.01479833
71	NCOR_22424771_ChIP-Seq_293T_Human	1.00738979
72	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.99871975
73	TAF2_19829295_ChIP-Seq_ESCs_Human	0.99706761
74	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.99606700
75	AR_20517297_ChIP-Seq_VCAP_Human	0.99287223
76	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.98899868
77	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.96610020
78	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.95659376
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.95546712
80	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.95416802
81	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.95393932
82	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.95214840
83	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.95106666
84	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94961976
85	AR_25329375_ChIP-Seq_VCAP_Human	0.94901318
86	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.93982937
87	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.93376046
88	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.93294846
89	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.91813465
90	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.91512113
91	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.90400909
92	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.90133058
93	TP53_22573176_ChIP-Seq_HFKS_Human	0.89442378
94	RUNX2_22187159_ChIP-Seq_PCA_Human	0.89104291
95	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.89057229
96	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.85411611
97	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.85309066
98	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.83485417
99	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.81829531
100	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.81661938

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.29353252
2	MP0003123_paternal_imprinting	4.36129719
3	MP0003787_abnormal_imprinting	4.30010267
4	MP0006292_abnormal_olfactory_placode	3.43522033
5	MP0008877_abnormal_DNA_methylation	3.22433223
6	MP0004142_abnormal_muscle_tone	3.17441617
7	MP0003122_maternal_imprinting	3.10041566
8	MP0002163_abnormal_gland_morphology	2.72524244
9	MP0003136_yellow_coat_color	2.68480075
10	MP0002653_abnormal_ependyma_morphology	2.65012130
11	MP0003121_genomic_imprinting	2.60213711
12	MP0000778_abnormal_nervous_system	2.41251675
13	MP0003880_abnormal_central_pattern	2.09482827
14	MP0001968_abnormal_touch/_nociception	1.91285381
15	MP0003646_muscle_fatigue	1.87373172
16	MP0006276_abnormal_autonomic_nervous	1.86525282
17	MP0008789_abnormal_olfactory_epithelium	1.83108136
18	MP0002735_abnormal_chemical_nociception	1.79895424
19	MP0002638_abnormal_pupillary_reflex	1.79291551
20	MP0001986_abnormal_taste_sensitivity	1.79104214
21	MP0001293_anophthalmia	1.74222511
22	MP0005379_endocrine/exocrine_gland_phen	1.73329998
23	MP0000631_abnormal_neuroendocrine_gland	1.72276430
24	MP0002736_abnormal_nociception_after	1.70609576
25	MP0001485_abnormal_pinna_reflex	1.70173217
26	MP0006072_abnormal_retinal_apoptosis	1.59499924
27	MP0002272_abnormal_nervous_system	1.57101221
28	MP0004742_abnormal_vestibular_system	1.54923944
29	MP0005499_abnormal_olfactory_system	1.45600473
30	MP0005394_taste/olfaction_phenotype	1.45600473
31	MP0009046_muscle_twitch	1.40810656
32	MP0008872_abnormal_physiological_respon	1.39945636
33	MP0001905_abnormal_dopamine_level	1.39884958
34	MP0002876_abnormal_thyroid_physiology	1.37010452
35	MP0000566_synostosis	1.35338618
36	MP0002733_abnormal_thermal_nociception	1.35240577
37	MP0008875_abnormal_xenobiotic_pharmacok	1.34384797
38	MP0000955_abnormal_spinal_cord	1.33957202
39	MP0005195_abnormal_posterior_eye	1.29649580
40	MP0005423_abnormal_somatic_nervous	1.28684602
41	MP0001970_abnormal_pain_threshold	1.27889108
42	MP0005645_abnormal_hypothalamus_physiol	1.26363716
43	MP0002557_abnormal_social/conspecific_i	1.25129533
44	MP0004145_abnormal_muscle_electrophysio	1.23165575
45	MP0002063_abnormal_learning/memory/cond	1.22386283
46	MP0002138_abnormal_hepatobiliary_system	1.22283509
47	MP0002184_abnormal_innervation	1.20542092
48	MP0009745_abnormal_behavioral_response	1.17161020
49	MP0002160_abnormal_reproductive_system	1.16716171
50	MP0002734_abnormal_mechanical_nocicepti	1.14632577
51	MP0002095_abnormal_skin_pigmentation	1.13691299
52	MP0004885_abnormal_endolymph	1.11866281
53	MP0002277_abnormal_respiratory_mucosa	1.11294691
54	MP0001348_abnormal_lacrimal_gland	1.11074270
55	MP0002067_abnormal_sensory_capabilities	1.10805343
56	MP0005551_abnormal_eye_electrophysiolog	1.08269956
57	MP0002938_white_spotting	1.08258373
58	MP0001286_abnormal_eye_development	1.06769136
59	MP0000049_abnormal_middle_ear	1.06168527
60	MP0002752_abnormal_somatic_nervous	1.03928248
61	MP0005084_abnormal_gallbladder_morpholo	1.02498510
62	MP0003635_abnormal_synaptic_transmissio	1.02357612
63	MP0001440_abnormal_grooming_behavior	1.01745638
64	MP0001486_abnormal_startle_reflex	1.01716643
65	MP0005389_reproductive_system_phenotype	1.00533557
66	MP0002572_abnormal_emotion/affect_behav	1.00230026
67	MP0004147_increased_porphyrin_level	1.00155849
68	MP0003942_abnormal_urinary_system	1.00081641
69	MP0003195_calcinosis	0.98443096
70	MP0009053_abnormal_anal_canal	0.98156159
71	MP0003879_abnormal_hair_cell	0.96691110
72	MP0002837_dystrophic_cardiac_calcinosis	0.96258470
73	MP0001324_abnormal_eye_pigmentation	0.95077451
74	MP0002233_abnormal_nose_morphology	0.93707229
75	MP0000427_abnormal_hair_cycle	0.92774328
76	MP0004133_heterotaxia	0.92564655
77	MP0003186_abnormal_redox_activity	0.90506954
78	MP0002882_abnormal_neuron_morphology	0.89470125
79	MP0002928_abnormal_bile_duct	0.88213176
80	MP0003890_abnormal_embryonic-extraembry	0.86795978
81	MP0002064_seizures	0.84202093
82	MP0000026_abnormal_inner_ear	0.84072187
83	MP0001188_hyperpigmentation	0.83517043
84	MP0001984_abnormal_olfaction	0.82306286
85	MP0004859_abnormal_synaptic_plasticity	0.79956913
86	MP0001529_abnormal_vocalization	0.79208436
87	MP0002152_abnormal_brain_morphology	0.78119995
88	MP0001963_abnormal_hearing_physiology	0.77487875
89	MP0004924_abnormal_behavior	0.77111311
90	MP0005386_behavior/neurological_phenoty	0.77111311
91	MP0003937_abnormal_limbs/digits/tail_de	0.76131996
92	MP0001919_abnormal_reproductive_system	0.75866400
93	MP0003938_abnormal_ear_development	0.75248455
94	MP0001663_abnormal_digestive_system	0.71537859
95	MP0003878_abnormal_ear_physiology	0.71335111
96	MP0005377_hearing/vestibular/ear_phenot	0.71335111
97	MP0010386_abnormal_urinary_bladder	0.71043970
98	MP0004130_abnormal_muscle_cell	0.70798411
99	MP0003315_abnormal_perineum_morphology	0.70409201
100	MP0002210_abnormal_sex_determination	0.70176142

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	6.72338128
2	Abnormality of cells of the erythroid lineage (HP:0012130)	4.79561407
3	Septo-optic dysplasia (HP:0100842)	4.49272207
4	Abnormality of midbrain morphology (HP:0002418)	3.93102956
5	Molar tooth sign on MRI (HP:0002419)	3.93102956
6	Stenosis of the external auditory canal (HP:0000402)	3.77479097
7	Tubular atrophy (HP:0000092)	3.65132370
8	Nephronophthisis (HP:0000090)	3.28957527
9	Macrocytic anemia (HP:0001972)	3.28141019
10	Acute necrotizing encephalopathy (HP:0006965)	3.14157116
11	Adrenal hypoplasia (HP:0000835)	3.13824814
12	Pancreatic fibrosis (HP:0100732)	3.12996842
13	Absent thumb (HP:0009777)	3.03991941
14	Abnormality of the labia minora (HP:0012880)	2.89171178
15	Agitation (HP:0000713)	2.87482631
16	Abnormality of DNA repair (HP:0003254)	2.85101573
17	Pancreatic cysts (HP:0001737)	2.77835157
18	Pallor (HP:0000980)	2.75001041
19	Optic nerve hypoplasia (HP:0000609)	2.64588386
20	Hip dysplasia (HP:0001385)	2.64230340
21	Rib fusion (HP:0000902)	2.62985174
22	Growth hormone deficiency (HP:0000824)	2.62363217
23	Hypoplasia of the ulna (HP:0003022)	2.59081795
24	Abnormal mitochondria in muscle tissue (HP:0008316)	2.58167035
25	Pendular nystagmus (HP:0012043)	2.55894785
26	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.55642985
27	Abnormality of the renal medulla (HP:0100957)	2.54946815
28	Medial flaring of the eyebrow (HP:0010747)	2.54097832
29	Acute encephalopathy (HP:0006846)	2.52963626
30	Progressive macrocephaly (HP:0004481)	2.50482168
31	Genetic anticipation (HP:0003743)	2.47285537
32	Absent septum pellucidum (HP:0001331)	2.45943939
33	Maternal diabetes (HP:0009800)	2.45612575
34	Mitochondrial inheritance (HP:0001427)	2.43714665
35	Abnormal pancreas size (HP:0012094)	2.43046689
36	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.42757289
37	Neoplasm of the adrenal cortex (HP:0100641)	2.42513732
38	Cystic liver disease (HP:0006706)	2.41160703
39	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.39782856
40	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.39782856
41	Colon cancer (HP:0003003)	2.38329715
42	Abnormal hemoglobin (HP:0011902)	2.38238263
43	Abnormal rod and cone electroretinograms (HP:0008323)	2.37181513
44	Oligomenorrhea (HP:0000876)	2.36530728
45	Hepatoblastoma (HP:0002884)	2.35542895
46	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.34883109
47	Aplasia/Hypoplasia of the ulna (HP:0006495)	2.34818872
48	True hermaphroditism (HP:0010459)	2.34359721
49	Abnormal number of erythroid precursors (HP:0012131)	2.33854813
50	Oligodactyly (hands) (HP:0001180)	2.31670671
51	Abnormality of the corticospinal tract (HP:0002492)	2.31383348
52	Papilledema (HP:0001085)	2.27097658
53	Polydipsia (HP:0001959)	2.26923075
54	Abnormal drinking behavior (HP:0030082)	2.26923075
55	Partial duplication of thumb phalanx (HP:0009944)	2.26678420
56	Confusion (HP:0001289)	2.26620508
57	Hypoplasia of the radius (HP:0002984)	2.25782960
58	Anophthalmia (HP:0000528)	2.23737072
59	Deep palmar crease (HP:0006191)	2.22679249
60	Chronic hepatic failure (HP:0100626)	2.21846658
61	Oligodactyly (HP:0012165)	2.19482947
62	Diastasis recti (HP:0001540)	2.17690963
63	Optic disc pallor (HP:0000543)	2.14735038
64	Polyphagia (HP:0002591)	2.14256536
65	Abnormality of reticulocytes (HP:0004312)	2.13742044
66	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.12169100
67	Forearm undergrowth (HP:0009821)	2.11751454
68	Tubulointerstitial fibrosis (HP:0005576)	2.11157312
69	Depressed nasal ridge (HP:0000457)	2.10839311
70	Anencephaly (HP:0002323)	2.10778439
71	Type II lissencephaly (HP:0007260)	2.08448698
72	Hepatocellular necrosis (HP:0001404)	2.07183526
73	Tubulointerstitial abnormality (HP:0001969)	2.06944242
74	Keratoconus (HP:0000563)	2.04662829
75	Increased corneal curvature (HP:0100692)	2.04662829
76	Sclerocornea (HP:0000647)	2.00472078
77	Abnormality of the septum pellucidum (HP:0007375)	1.98618839
78	Irregular vertebral endplates (HP:0003301)	1.96441347
79	Increased CSF lactate (HP:0002490)	1.94358038
80	Abnormality of the renal cortex (HP:0011035)	1.91380315
81	Hyperthyroidism (HP:0000836)	1.91364294
82	Gait imbalance (HP:0002141)	1.90896949
83	Abnormality of the diencephalon (HP:0010662)	1.88725068
84	Horseshoe kidney (HP:0000085)	1.88332737
85	Inability to walk (HP:0002540)	1.87468677
86	Partial duplication of the phalanx of hand (HP:0009999)	1.86815380
87	Flat capital femoral epiphysis (HP:0003370)	1.85828011
88	Congenital stationary night blindness (HP:0007642)	1.82934287
89	Thyroid-stimulating hormone excess (HP:0002925)	1.82682211
90	Fibular hypoplasia (HP:0003038)	1.82566896
91	Enlarged kidneys (HP:0000105)	1.82477969
92	Asplenia (HP:0001746)	1.80816252
93	Abnormality of the aortic arch (HP:0012303)	1.80773038
94	Triphalangeal thumb (HP:0001199)	1.80719469
95	Morphological abnormality of the pyramidal tract (HP:0002062)	1.80691598
96	Congenital primary aphakia (HP:0007707)	1.78196456
97	Ectopic kidney (HP:0000086)	1.77424732
98	Male pseudohermaphroditism (HP:0000037)	1.75798704
99	Hepatic necrosis (HP:0002605)	1.73276567
100	Narrow forehead (HP:0000341)	1.73065852

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	3.35106104
2	FRK	2.96546419
3	PINK1	2.89926369
4	EPHB2	2.86545519
5	PNCK	2.53405880
6	CDK19	2.48376085
7	DYRK2	2.42578903
8	MAP3K11	2.42284440
9	ICK	2.39632646
10	NUAK1	2.20693653
11	CASK	2.18402396
12	GRK1	2.05066864
13	MAP4K2	2.03882028
14	WNK1	1.99683439
15	LRRK2	1.99169497
16	BRAF	1.78710549
17	MAP3K12	1.73314049
18	ADRBK2	1.70363531
19	EPHA4	1.67329556
20	TYRO3	1.63650065
21	AKT3	1.54143873
22	PIK3CA	1.50182253
23	PAK3	1.47659660
24	STK39	1.45546477
25	CAMKK2	1.44396586
26	PRKCG	1.44339587
27	STK16	1.42076029
28	CAMK1	1.41689782
29	TNIK	1.37833653
30	CAMK1G	1.34013257
31	NTRK2	1.28282215
32	LIMK1	1.25868589
33	DYRK1B	1.25821395
34	TRIM28	1.17358039
35	KSR1	1.11357869
36	PLK4	1.07723320
37	MAP3K9	0.99421692
38	CDK8	0.98000094
39	CAMK1D	0.91836394
40	BMPR1B	0.91332841
41	STK11	0.90766853
42	WNK3	0.90360442
43	PLK2	0.89586543
44	VRK2	0.89277470
45	ZAK	0.87134901
46	MAP3K4	0.86208278
47	STK3	0.84469479
48	DAPK3	0.82466866
49	PRKCQ	0.81746193
50	SGK223	0.81721860
51	SGK494	0.81721860
52	PRKCZ	0.77721798
53	CSNK1E	0.74446910
54	PHKG1	0.74367348
55	PHKG2	0.74367348
56	MAP2K4	0.72670514
57	STK24	0.71580804
58	MARK1	0.69090651
59	MAP2K7	0.68515227
60	ARAF	0.68359801
61	PRKCH	0.67031486
62	PRKACA	0.64928096
63	ADRBK1	0.63602494
64	MKNK2	0.63208235
65	MARK3	0.61012182
66	INSRR	0.60630641
67	NEK2	0.60516134
68	RPS6KA6	0.58899985
69	DYRK1A	0.57662223
70	PRKCE	0.56557975
71	BCKDK	0.54084000
72	NTRK3	0.52945725
73	TAF1	0.52565193
74	MAPK13	0.52037478
75	MINK1	0.51946917
76	CSNK1G2	0.51594857
77	CAMKK1	0.51493318
78	CSNK2A2	0.51258852
79	PRKCI	0.49661137
80	SGK1	0.49525747
81	MUSK	0.49164314
82	DMPK	0.45670886
83	OXSR1	0.44222976
84	CDC7	0.43504148
85	TGFBR1	0.43034594
86	TIE1	0.42692828
87	EIF2AK1	0.41689392
88	AURKA	0.41551193
89	PRKD3	0.39905418
90	RPS6KL1	0.39386041
91	RPS6KC1	0.39386041
92	MAP2K2	0.38170036
93	PRKG1	0.37825987
94	VRK1	0.37202916
95	CAMK4	0.36747060
96	PLK1	0.34217219
97	PRKAA1	0.33870049
98	ERBB2	0.33462854
99	CSNK1A1	0.32621297
100	OBSCN	0.32021784

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.33824927
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.68439623
3	Parkinsons disease_Homo sapiens_hsa05012	3.26871321
4	Linoleic acid metabolism_Homo sapiens_hsa00591	3.12557460
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.91397650
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.87404492
7	Sulfur relay system_Homo sapiens_hsa04122	2.83405857
8	Protein export_Homo sapiens_hsa03060	2.59499999
9	Huntingtons disease_Homo sapiens_hsa05016	2.26835394
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.18539933
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.18148450
12	Alzheimers disease_Homo sapiens_hsa05010	2.18073593
13	RNA polymerase_Homo sapiens_hsa03020	2.05980717
14	Asthma_Homo sapiens_hsa05310	1.93629579
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.88666026
16	Nicotine addiction_Homo sapiens_hsa05033	1.79294442
17	Ether lipid metabolism_Homo sapiens_hsa00565	1.66627391
18	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.51195453
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.46097247
20	Butanoate metabolism_Homo sapiens_hsa00650	1.35114923
21	Basal transcription factors_Homo sapiens_hsa03022	1.34766515
22	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.34557710
23	Phototransduction_Homo sapiens_hsa04744	1.31721174
24	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.27950053
25	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.19360609
26	Insulin secretion_Homo sapiens_hsa04911	1.19316187
27	Morphine addiction_Homo sapiens_hsa05032	1.10085033
28	Steroid biosynthesis_Homo sapiens_hsa00100	1.08642807
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.08603058
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.06217693
31	Caffeine metabolism_Homo sapiens_hsa00232	1.04470928
32	Peroxisome_Homo sapiens_hsa04146	1.04122879
33	RNA degradation_Homo sapiens_hsa03018	1.02598605
34	Fat digestion and absorption_Homo sapiens_hsa04975	1.01806161
35	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.01529261
36	Basal cell carcinoma_Homo sapiens_hsa05217	0.99784053
37	Fanconi anemia pathway_Homo sapiens_hsa03460	0.98090005
38	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.96482441
39	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.96086554
40	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.90187140
41	Tryptophan metabolism_Homo sapiens_hsa00380	0.84780447
42	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.84128491
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.83555817
44	Glutamatergic synapse_Homo sapiens_hsa04724	0.81476238
45	Propanoate metabolism_Homo sapiens_hsa00640	0.79260417
46	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.78882221
47	Sulfur metabolism_Homo sapiens_hsa00920	0.77390062
48	Axon guidance_Homo sapiens_hsa04360	0.75746204
49	Olfactory transduction_Homo sapiens_hsa04740	0.75347663
50	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.75028060
51	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.71903056
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.70065225
53	Notch signaling pathway_Homo sapiens_hsa04330	0.68373114
54	GABAergic synapse_Homo sapiens_hsa04727	0.67727221
55	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.66584912
56	Retinol metabolism_Homo sapiens_hsa00830	0.66110953
57	Glycerolipid metabolism_Homo sapiens_hsa00561	0.65636420
58	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.64722509
59	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.64427516
60	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.64085498
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.63736291
62	Allograft rejection_Homo sapiens_hsa05330	0.63623797
63	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.62959380
64	Serotonergic synapse_Homo sapiens_hsa04726	0.61290816
65	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.60947014
66	Metabolic pathways_Homo sapiens_hsa01100	0.58684700
67	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.58615921
68	Purine metabolism_Homo sapiens_hsa00230	0.57786134
69	Folate biosynthesis_Homo sapiens_hsa00790	0.56684906
70	Homologous recombination_Homo sapiens_hsa03440	0.55256776
71	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.54046838
72	Chemical carcinogenesis_Homo sapiens_hsa05204	0.53997997
73	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.53567355
74	Hippo signaling pathway_Homo sapiens_hsa04390	0.53380141
75	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.51928284
76	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.49397605
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46770301
78	Pyrimidine metabolism_Homo sapiens_hsa00240	0.46193454
79	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.45104841
80	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.44971414
81	beta-Alanine metabolism_Homo sapiens_hsa00410	0.43474589
82	Circadian entrainment_Homo sapiens_hsa04713	0.42187928
83	Cholinergic synapse_Homo sapiens_hsa04725	0.41220430
84	Arginine and proline metabolism_Homo sapiens_hsa00330	0.39850556
85	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.37902253
86	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.37577828
87	Dopaminergic synapse_Homo sapiens_hsa04728	0.36502986
88	Ras signaling pathway_Homo sapiens_hsa04014	0.36423193
89	Collecting duct acid secretion_Homo sapiens_hsa04966	0.36064639
90	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.36051973
91	Nucleotide excision repair_Homo sapiens_hsa03420	0.34974987
92	Salivary secretion_Homo sapiens_hsa04970	0.34632425
93	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.30576960
94	Fatty acid degradation_Homo sapiens_hsa00071	0.30340803
95	RNA transport_Homo sapiens_hsa03013	0.29927151
96	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.27506376
97	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.26988647
98	cAMP signaling pathway_Homo sapiens_hsa04024	0.26320753
99	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.25836781
100	Fatty acid elongation_Homo sapiens_hsa00062	0.23875370

RPL26P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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