RPL26P30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.06689402
2ATP synthesis coupled proton transport (GO:0015986)7.38034744
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.38034744
4viral transcription (GO:0019083)7.21605469
5translational termination (GO:0006415)6.88642759
6sequestering of actin monomers (GO:0042989)6.80732704
7cotranslational protein targeting to membrane (GO:0006613)6.00258970
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.97897996
9behavioral response to nicotine (GO:0035095)5.91144396
10protein targeting to ER (GO:0045047)5.90921065
11neuron fate determination (GO:0048664)5.85124810
12ribosomal small subunit assembly (GO:0000028)5.64706751
13establishment of protein localization to endoplasmic reticulum (GO:0072599)5.64387450
14translational elongation (GO:0006414)5.62852339
15protein localization to endoplasmic reticulum (GO:0070972)5.45061102
16cellular protein complex disassembly (GO:0043624)5.28281002
17viral life cycle (GO:0019058)5.20055326
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.17019365
19maturation of SSU-rRNA (GO:0030490)5.06412782
20establishment of protein localization to mitochondrial membrane (GO:0090151)4.98242771
21respiratory electron transport chain (GO:0022904)4.93586017
22ribosomal small subunit biogenesis (GO:0042274)4.92956774
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.89058221
24electron transport chain (GO:0022900)4.87227778
25epithelial cilium movement (GO:0003351)4.84580188
26translational initiation (GO:0006413)4.56091524
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.54616101
28protein complex disassembly (GO:0043241)4.41698321
29axonemal dynein complex assembly (GO:0070286)4.39353316
30protein complex biogenesis (GO:0070271)4.33562502
31mitochondrial respiratory chain complex I assembly (GO:0032981)4.31033997
32NADH dehydrogenase complex assembly (GO:0010257)4.31033997
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.31033997
34chaperone-mediated protein transport (GO:0072321)4.21446591
35macromolecular complex disassembly (GO:0032984)4.14543225
36ATP biosynthetic process (GO:0006754)4.14390395
37mitochondrial respiratory chain complex assembly (GO:0033108)4.10660317
38cilium movement (GO:0003341)4.04014479
39protein targeting to membrane (GO:0006612)3.85140814
40purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.73109680
41protein neddylation (GO:0045116)3.70988671
42hydrogen ion transmembrane transport (GO:1902600)3.69926663
43purine nucleoside triphosphate biosynthetic process (GO:0009145)3.68197114
44spinal cord association neuron differentiation (GO:0021527)3.58006999
45protein polyglutamylation (GO:0018095)3.44560658
46nuclear-transcribed mRNA catabolic process (GO:0000956)3.42953517
47proton transport (GO:0015992)3.37962584
48translation (GO:0006412)3.32715927
49hydrogen transport (GO:0006818)3.29652317
50ribosomal large subunit biogenesis (GO:0042273)3.27563787
51mRNA catabolic process (GO:0006402)3.26213894
52platelet dense granule organization (GO:0060155)3.22237072
53cell proliferation in forebrain (GO:0021846)3.19334141
54inner mitochondrial membrane organization (GO:0007007)3.18021710
55ribonucleoside triphosphate biosynthetic process (GO:0009201)3.12349037
56somite development (GO:0061053)3.07515151
57transmission of nerve impulse (GO:0019226)3.05307604
58protein-cofactor linkage (GO:0018065)3.02949072
59synaptic transmission, cholinergic (GO:0007271)2.95495148
60limb bud formation (GO:0060174)2.89427505
61negative regulation of transcription regulatory region DNA binding (GO:2000678)2.86552936
62RNA catabolic process (GO:0006401)2.82042277
63pyrimidine nucleobase catabolic process (GO:0006208)2.81087235
64retinal ganglion cell axon guidance (GO:0031290)2.80224187
65determination of left/right symmetry (GO:0007368)2.80017449
66nucleoside triphosphate biosynthetic process (GO:0009142)2.79413582
67nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.67555309
68positive regulation of fatty acid beta-oxidation (GO:0032000)2.67024790
69exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.65889557
70intracellular protein transmembrane import (GO:0044743)2.64762945
71otic vesicle formation (GO:0030916)2.64684487
72cell differentiation in spinal cord (GO:0021515)2.64194994
73neuron fate specification (GO:0048665)2.63490421
74transcription elongation from RNA polymerase III promoter (GO:0006385)2.63342815
75termination of RNA polymerase III transcription (GO:0006386)2.63342815
76DNA damage response, detection of DNA damage (GO:0042769)2.63174883
77determination of bilateral symmetry (GO:0009855)2.56810630
78DNA deamination (GO:0045006)2.55845285
79neuromuscular synaptic transmission (GO:0007274)2.55516483
80establishment of protein localization to membrane (GO:0090150)2.54775393
81specification of symmetry (GO:0009799)2.52974354
82neuronal stem cell maintenance (GO:0097150)2.51057654
83protein targeting (GO:0006605)2.50087000
84left/right pattern formation (GO:0060972)2.50026083
85cornea development in camera-type eye (GO:0061303)2.47806140
86midbrain development (GO:0030901)2.43583397
87spliceosomal complex assembly (GO:0000245)2.42676751
88GTP biosynthetic process (GO:0006183)2.42387413
89cellular component biogenesis (GO:0044085)2.41548218
90nephron epithelium morphogenesis (GO:0072088)2.41381118
91nephron tubule morphogenesis (GO:0072078)2.41381118
92cAMP catabolic process (GO:0006198)2.40459583
93somite rostral/caudal axis specification (GO:0032525)2.39517960
94positive regulation of fatty acid oxidation (GO:0046321)2.38799468
95establishment of protein localization to organelle (GO:0072594)2.38352005
96sulfation (GO:0051923)2.36133201
97heme transport (GO:0015886)2.35736625
98water-soluble vitamin biosynthetic process (GO:0042364)2.35507501
99dendritic spine morphogenesis (GO:0060997)2.33865321
100regulation of cilium movement (GO:0003352)2.32783972

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.93870100
2EST1_17652178_ChIP-ChIP_JURKAT_Human3.11917920
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.10661013
4VDR_22108803_ChIP-Seq_LS180_Human3.03133390
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.02606146
6ZNF274_21170338_ChIP-Seq_K562_Hela2.66095979
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.64756642
8CBX2_27304074_Chip-Seq_ESCs_Mouse2.62805368
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.46863810
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.44056438
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.37510160
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.32611034
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.23817773
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.14148767
15TAF15_26573619_Chip-Seq_HEK293_Human2.12470995
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.04024304
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03337510
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.02269598
19EWS_26573619_Chip-Seq_HEK293_Human1.95600143
20FUS_26573619_Chip-Seq_HEK293_Human1.95077087
21IGF1R_20145208_ChIP-Seq_DFB_Human1.92340778
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.92125794
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91694489
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91658097
25GBX2_23144817_ChIP-Seq_PC3_Human1.90250398
26RNF2_27304074_Chip-Seq_NSC_Mouse1.85041192
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83167778
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.81979372
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79628205
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76795845
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.74724962
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66425980
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.66040062
34IRF1_19129219_ChIP-ChIP_H3396_Human1.62384872
35MYC_18940864_ChIP-ChIP_HL60_Human1.61779059
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.61182736
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.61044006
38P300_19829295_ChIP-Seq_ESCs_Human1.57644022
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56075621
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.55385146
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55351324
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53114089
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.47337302
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.46406008
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46040208
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45356691
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45356691
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42321593
49GATA1_26923725_Chip-Seq_HPCs_Mouse1.41716399
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40604536
51SOX2_16153702_ChIP-ChIP_HESCs_Human1.39628473
52ELK1_19687146_ChIP-ChIP_HELA_Human1.38473676
53REST_21632747_ChIP-Seq_MESCs_Mouse1.37009876
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33851464
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33146044
56RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31005730
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31005730
58BCAT_22108803_ChIP-Seq_LS180_Human1.28908137
59SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28401447
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.26099244
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25850068
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21738824
63RNF2_27304074_Chip-Seq_ESCs_Mouse1.20882646
64JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19282784
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17656820
66TTF2_22483619_ChIP-Seq_HELA_Human1.16321341
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16205570
68TP53_22573176_ChIP-Seq_HFKS_Human1.14569915
69REST_18959480_ChIP-ChIP_MESCs_Mouse1.14073028
70VDR_23849224_ChIP-Seq_CD4+_Human1.13881927
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13047587
72ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11026282
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.09889123
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09532566
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.09166370
76FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07025215
77CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05992203
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05987857
79ER_23166858_ChIP-Seq_MCF-7_Human1.05972043
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05086089
81NCOR_22424771_ChIP-Seq_293T_Human1.04948458
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03932141
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01664058
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00594854
85CBP_20019798_ChIP-Seq_JUKART_Human1.00594854
86AR_25329375_ChIP-Seq_VCAP_Human0.99618691
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96409780
88SOX2_19829295_ChIP-Seq_ESCs_Human0.96280215
89NANOG_19829295_ChIP-Seq_ESCs_Human0.96280215
90TP53_20018659_ChIP-ChIP_R1E_Mouse0.94667138
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94659089
92AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92980543
93NANOG_16153702_ChIP-ChIP_HESCs_Human0.92927306
94PIAS1_25552417_ChIP-Seq_VCAP_Human0.91418080
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91014066
96SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90096520
97MYC_18555785_ChIP-Seq_MESCs_Mouse0.89502198
98LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89356039
99TCF4_22108803_ChIP-Seq_LS180_Human0.88931198
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88601534

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.51612929
2MP0002638_abnormal_pupillary_reflex3.69059382
3MP0006292_abnormal_olfactory_placode2.89522742
4MP0003136_yellow_coat_color2.51332397
5MP0002938_white_spotting2.36527845
6MP0004133_heterotaxia2.31191301
7MP0010030_abnormal_orbit_morphology2.13023067
8MP0003011_delayed_dark_adaptation2.09102724
9MP0000631_abnormal_neuroendocrine_gland2.01955734
10MP0004142_abnormal_muscle_tone2.00967266
11MP0003787_abnormal_imprinting1.97497831
12MP0004742_abnormal_vestibular_system1.95948060
13MP0000566_synostosis1.95439601
14MP0003283_abnormal_digestive_organ1.91563031
15MP0005645_abnormal_hypothalamus_physiol1.86153870
16MP0006276_abnormal_autonomic_nervous1.83415361
17MP0006072_abnormal_retinal_apoptosis1.83232145
18MP0004885_abnormal_endolymph1.82248271
19MP0005084_abnormal_gallbladder_morpholo1.81496350
20MP0001986_abnormal_taste_sensitivity1.67900234
21MP0008877_abnormal_DNA_methylation1.66719904
22MP0000778_abnormal_nervous_system1.65151620
23MP0005551_abnormal_eye_electrophysiolog1.62832196
24MP0001529_abnormal_vocalization1.62102466
25MP0000026_abnormal_inner_ear1.61420141
26MP0001485_abnormal_pinna_reflex1.54912834
27MP0009745_abnormal_behavioral_response1.52484372
28MP0002272_abnormal_nervous_system1.50049253
29MP0009046_muscle_twitch1.47858867
30MP0002734_abnormal_mechanical_nocicepti1.46612415
31MP0005646_abnormal_pituitary_gland1.46254144
32MP0002653_abnormal_ependyma_morphology1.45942464
33MP0000049_abnormal_middle_ear1.43974602
34MP0003938_abnormal_ear_development1.43188172
35MP0001968_abnormal_touch/_nociception1.42186055
36MP0002928_abnormal_bile_duct1.41852994
37MP0002277_abnormal_respiratory_mucosa1.41531272
38MP0005253_abnormal_eye_physiology1.40670577
39MP0002735_abnormal_chemical_nociception1.39835971
40MP0004145_abnormal_muscle_electrophysio1.34338831
41MP0001286_abnormal_eye_development1.32937610
42MP0002095_abnormal_skin_pigmentation1.32553991
43MP0002752_abnormal_somatic_nervous1.31556607
44MP0008875_abnormal_xenobiotic_pharmacok1.31313129
45MP0002163_abnormal_gland_morphology1.30456136
46MP0003122_maternal_imprinting1.30334350
47MP0003880_abnormal_central_pattern1.29738536
48MP0002736_abnormal_nociception_after1.29561691
49MP0005195_abnormal_posterior_eye1.29213674
50MP0001293_anophthalmia1.26403283
51MP0002184_abnormal_innervation1.26347444
52MP0002557_abnormal_social/conspecific_i1.23985111
53MP0001440_abnormal_grooming_behavior1.21903365
54MP0003195_calcinosis1.21827257
55MP0004147_increased_porphyrin_level1.21391845
56MP0001970_abnormal_pain_threshold1.21115084
57MP0003121_genomic_imprinting1.20696270
58MP0005423_abnormal_somatic_nervous1.20213185
59MP0008872_abnormal_physiological_respon1.19779139
60MP0001905_abnormal_dopamine_level1.18412404
61MP0003937_abnormal_limbs/digits/tail_de1.16489482
62MP0005171_absent_coat_pigmentation1.13910009
63MP0008995_early_reproductive_senescence1.13751194
64MP0009250_abnormal_appendicular_skeleto1.09484136
65MP0002572_abnormal_emotion/affect_behav1.08607089
66MP0001984_abnormal_olfaction1.08145837
67MP0003119_abnormal_digestive_system1.06273190
68MP0002138_abnormal_hepatobiliary_system1.04775180
69MP0000955_abnormal_spinal_cord1.03588158
70MP0002160_abnormal_reproductive_system1.02799887
71MP0002064_seizures1.01950402
72MP0002733_abnormal_thermal_nociception0.98268832
73MP0002139_abnormal_hepatobiliary_system0.96370814
74MP0002876_abnormal_thyroid_physiology0.96226009
75MP0008789_abnormal_olfactory_epithelium0.95754527
76MP0002882_abnormal_neuron_morphology0.95213815
77MP0004019_abnormal_vitamin_homeostasis0.94464508
78MP0002751_abnormal_autonomic_nervous0.92617511
79MP0003878_abnormal_ear_physiology0.91847980
80MP0005377_hearing/vestibular/ear_phenot0.91847980
81MP0001324_abnormal_eye_pigmentation0.90867692
82MP0003635_abnormal_synaptic_transmissio0.90624587
83MP0003646_muscle_fatigue0.90218965
84MP0005391_vision/eye_phenotype0.89974625
85MP0003942_abnormal_urinary_system0.89351629
86MP0002067_abnormal_sensory_capabilities0.89159855
87MP0002697_abnormal_eye_size0.88245086
88MP0000372_irregular_coat_pigmentation0.86097693
89MP0005389_reproductive_system_phenotype0.85012185
90MP0003861_abnormal_nervous_system0.84500511
91MP0000647_abnormal_sebaceous_gland0.83450926
92MP0010386_abnormal_urinary_bladder0.83268033
93MP0001486_abnormal_startle_reflex0.81090607
94MP0001919_abnormal_reproductive_system0.78000574
95MP0002152_abnormal_brain_morphology0.76263309
96MP0002063_abnormal_learning/memory/cond0.75667058
97MP0002837_dystrophic_cardiac_calcinosis0.75312488
98MP0005379_endocrine/exocrine_gland_phen0.74333321
99MP0001963_abnormal_hearing_physiology0.73930527
100MP0005394_taste/olfaction_phenotype0.73475599

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)4.98305251
2Lipid accumulation in hepatocytes (HP:0006561)4.63277852
3Acute necrotizing encephalopathy (HP:0006965)4.57595001
4Abnormality of cells of the erythroid lineage (HP:0012130)4.43805810
5Congenital, generalized hypertrichosis (HP:0004540)4.12937000
6Abnormal number of erythroid precursors (HP:0012131)4.12635489
7Mitochondrial inheritance (HP:0001427)4.09797094
8Renal Fanconi syndrome (HP:0001994)4.04704422
9Abnormal mitochondria in muscle tissue (HP:0008316)4.00313167
10Acute encephalopathy (HP:0006846)3.94406473
11Abnormal ciliary motility (HP:0012262)3.80758011
12Reticulocytopenia (HP:0001896)3.77946175
13Molar tooth sign on MRI (HP:0002419)3.72364210
14Abnormality of midbrain morphology (HP:0002418)3.72364210
15Progressive macrocephaly (HP:0004481)3.68988631
16Abnormal respiratory motile cilium physiology (HP:0012261)3.61340004
17Macrocytic anemia (HP:0001972)3.58331093
18Increased CSF lactate (HP:0002490)3.45532083
19True hermaphroditism (HP:0010459)3.36601290
20Pancreatic fibrosis (HP:0100732)3.33292150
21Exertional dyspnea (HP:0002875)3.29496280
22Pancreatic cysts (HP:0001737)3.25754907
23Abnormal respiratory epithelium morphology (HP:0012253)3.13324791
24Abnormal respiratory motile cilium morphology (HP:0005938)3.13324791
25Increased intramyocellular lipid droplets (HP:0012240)3.07154345
26Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.05033170
27Concave nail (HP:0001598)2.96309675
28Pallor (HP:0000980)2.93884448
29Nephronophthisis (HP:0000090)2.89787478
30Myokymia (HP:0002411)2.84879240
31Glycosuria (HP:0003076)2.81757983
32Abnormality of urine glucose concentration (HP:0011016)2.81757983
33Rhinitis (HP:0012384)2.80998786
343-Methylglutaconic aciduria (HP:0003535)2.80081561
35Abnormality of renal resorption (HP:0011038)2.77673013
36Medial flaring of the eyebrow (HP:0010747)2.75368115
37Congenital stationary night blindness (HP:0007642)2.74348142
38Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.64497105
39Hepatocellular necrosis (HP:0001404)2.62354202
40Increased muscle lipid content (HP:0009058)2.58846695
41Cerebral edema (HP:0002181)2.56272374
42Abnormality of the phalanges of the 2nd finger (HP:0009541)2.53543594
43Septo-optic dysplasia (HP:0100842)2.53383194
44Abnormality of the renal medulla (HP:0100957)2.43579427
45Stenosis of the external auditory canal (HP:0000402)2.39562383
46Hyperphosphaturia (HP:0003109)2.34457633
47Optic disc pallor (HP:0000543)2.34314743
48Chronic sinusitis (HP:0011109)2.32820266
49Respiratory difficulties (HP:0002880)2.30662423
50Anencephaly (HP:0002323)2.29684001
51Limb dystonia (HP:0002451)2.28145088
52Hepatic necrosis (HP:0002605)2.27779309
53Pendular nystagmus (HP:0012043)2.26997965
54Leukodystrophy (HP:0002415)2.20083551
55Sclerocornea (HP:0000647)2.16386906
56Cystic liver disease (HP:0006706)2.14697448
57Dynein arm defect of respiratory motile cilia (HP:0012255)2.14159708
58Absent/shortened dynein arms (HP:0200106)2.14159708
59Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.12152144
60Gait imbalance (HP:0002141)2.09856605
61Chronic hepatic failure (HP:0100626)2.08756242
62Agitation (HP:0000713)2.05783609
63Polyphagia (HP:0002591)2.05363537
64Partial duplication of the phalanx of hand (HP:0009999)2.00959013
65Ulnar claw (HP:0001178)2.00840142
66Lactic acidosis (HP:0003128)2.00648640
67Nephrogenic diabetes insipidus (HP:0009806)1.98717720
68Abnormal drinking behavior (HP:0030082)1.97886875
69Polydipsia (HP:0001959)1.97886875
70Abnormality of the pons (HP:0007361)1.97257166
71Abnormal urine phosphate concentration (HP:0012599)1.96053450
72Congenital primary aphakia (HP:0007707)1.95778800
73Increased serum lactate (HP:0002151)1.95532065
74Rib fusion (HP:0000902)1.94909045
75Hypoplasia of the pons (HP:0012110)1.93761032
76Male pseudohermaphroditism (HP:0000037)1.93282410
77Aplasia/Hypoplasia of the sacrum (HP:0008517)1.92726441
78Exercise intolerance (HP:0003546)1.91900573
79Aplasia/Hypoplasia of the tongue (HP:0010295)1.90421783
80Abnormality of the labia minora (HP:0012880)1.90402985
81Lissencephaly (HP:0001339)1.88582891
82Polyuria (HP:0000103)1.85713607
83Decreased central vision (HP:0007663)1.83581514
84Depressed nasal ridge (HP:0000457)1.82100276
85Decreased activity of mitochondrial respiratory chain (HP:0008972)1.82018062
86Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.82018062
87Genital tract atresia (HP:0001827)1.81299225
88Furrowed tongue (HP:0000221)1.81222190
89Abnormal biliary tract physiology (HP:0012439)1.80354903
90Bile duct proliferation (HP:0001408)1.80354903
91Vaginal atresia (HP:0000148)1.79690101
92Abnormal rod and cone electroretinograms (HP:0008323)1.77489091
93Increased corneal curvature (HP:0100692)1.77006521
94Keratoconus (HP:0000563)1.77006521
95Respiratory failure (HP:0002878)1.73455759
96Type II lissencephaly (HP:0007260)1.72839952
97Thyroid-stimulating hormone excess (HP:0002925)1.67157385
98Absent septum pellucidum (HP:0001331)1.65378383
99Abnormality of the renal cortex (HP:0011035)1.64509130
100Occipital encephalocele (HP:0002085)1.64081371

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK13.21199933
2TAF12.69154203
3VRK22.54499991
4GRK12.44161388
5PNCK2.36438673
6DYRK22.27349077
7NUAK12.26853149
8EPHB22.19739379
9MAPK152.18614110
10VRK12.18362670
11ADRBK22.15034252
12WNK32.14862131
13PASK2.10756492
14ZAK1.88760373
15WNK41.86685983
16MARK11.85205822
17NTRK31.71398579
18CDK191.68589906
19MAP3K41.66905090
20MAP2K71.65904981
21CASK1.65561180
22WEE11.59516454
23PINK11.58757700
24BMPR1B1.51132469
25STK161.50169313
26INSRR1.50085850
27OXSR11.48973835
28MAPK131.46157918
29DYRK31.44763298
30BUB11.44727585
31PIK3CA1.36365920
32STK391.25843979
33TGFBR11.24306159
34PRKCG1.22181378
35FRK1.02480550
36TIE11.02351072
37MINK11.00465273
38CDC70.97943999
39TXK0.96298433
40PAK30.94119543
41NTRK20.93726333
42LRRK20.93553752
43ADRBK10.91799422
44PLK30.87622774
45MAP3K90.86731402
46NME10.83063966
47TSSK60.82617726
48MAP3K120.80940237
49BRAF0.79270524
50SIK20.78346069
51CSNK1G20.77246152
52PKN10.75371712
53MAP2K40.75100623
54NEK20.71488455
55PLK40.70064943
56PRKCE0.68918789
57MST40.68245435
58MAP4K20.67161174
59STK240.66193656
60CCNB10.65926396
61FGFR20.65602719
62PRKACA0.65034090
63STK110.64407660
64TNIK0.63856345
65DYRK1A0.62441574
66PRKG10.60974254
67DYRK1B0.59714657
68PRKCQ0.58726409
69EPHA40.57884928
70PLK20.57761312
71CSNK2A20.56655049
72BCKDK0.56153211
73OBSCN0.54892559
74ERBB20.54796014
75CSNK2A10.54559849
76CDK30.53622507
77RPS6KA50.52434386
78MAPKAPK50.52356105
79CHEK20.51949593
80AURKB0.50445765
81UHMK10.50210700
82CSNK1E0.49613848
83DAPK30.49418821
84CAMK2A0.48282561
85ERBB30.48028845
86TRIM280.47975001
87SGK2230.47937078
88SGK4940.47937078
89CDK80.47462369
90CSNK1G30.46573278
91TAOK30.45140437
92AURKA0.44819043
93PHKG20.44678215
94PHKG10.44678215
95RPS6KA60.44192609
96MKNK20.40475672
97MUSK0.39157869
98MKNK10.39106144
99BCR0.38683506
100ACVR1B0.37325973

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.61757782
2Oxidative phosphorylation_Homo sapiens_hsa001905.17708173
3Parkinsons disease_Homo sapiens_hsa050124.34544965
4Alzheimers disease_Homo sapiens_hsa050103.05813001
5Protein export_Homo sapiens_hsa030603.03730225
6Huntingtons disease_Homo sapiens_hsa050163.02535174
7Cardiac muscle contraction_Homo sapiens_hsa042602.82488879
8Proteasome_Homo sapiens_hsa030502.80015627
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.74927524
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13956808
11RNA polymerase_Homo sapiens_hsa030202.03685297
12Phototransduction_Homo sapiens_hsa047441.96498405
13Nicotine addiction_Homo sapiens_hsa050331.88806535
14Butanoate metabolism_Homo sapiens_hsa006501.80095698
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.63389539
16Basal cell carcinoma_Homo sapiens_hsa052171.54901514
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51230830
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50120445
19Caffeine metabolism_Homo sapiens_hsa002321.40638653
20Basal transcription factors_Homo sapiens_hsa030221.30977845
21Hedgehog signaling pathway_Homo sapiens_hsa043401.21529602
22Sulfur relay system_Homo sapiens_hsa041221.19182256
23Homologous recombination_Homo sapiens_hsa034401.18969729
24Linoleic acid metabolism_Homo sapiens_hsa005911.18662448
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17898619
26RNA degradation_Homo sapiens_hsa030181.15326893
27Morphine addiction_Homo sapiens_hsa050321.11146819
28Olfactory transduction_Homo sapiens_hsa047401.10110318
29Tryptophan metabolism_Homo sapiens_hsa003801.09445568
30Nitrogen metabolism_Homo sapiens_hsa009101.03174570
31Chemical carcinogenesis_Homo sapiens_hsa052041.00602662
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98408279
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95371508
34Taste transduction_Homo sapiens_hsa047420.93423393
35Collecting duct acid secretion_Homo sapiens_hsa049660.88105971
36Folate biosynthesis_Homo sapiens_hsa007900.87864732
37Purine metabolism_Homo sapiens_hsa002300.87609293
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84806976
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79096851
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76880781
41Steroid biosynthesis_Homo sapiens_hsa001000.75429230
42GABAergic synapse_Homo sapiens_hsa047270.73878704
43Steroid hormone biosynthesis_Homo sapiens_hsa001400.71021158
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70884645
45Fanconi anemia pathway_Homo sapiens_hsa034600.70857880
46Spliceosome_Homo sapiens_hsa030400.68172274
47Peroxisome_Homo sapiens_hsa041460.67316881
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66434407
49Selenocompound metabolism_Homo sapiens_hsa004500.66135004
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66083239
51Propanoate metabolism_Homo sapiens_hsa006400.65348974
52Pyrimidine metabolism_Homo sapiens_hsa002400.63914586
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61673418
54Glutamatergic synapse_Homo sapiens_hsa047240.61567830
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61386350
56Pyruvate metabolism_Homo sapiens_hsa006200.60682273
57Fat digestion and absorption_Homo sapiens_hsa049750.60558819
58Retinol metabolism_Homo sapiens_hsa008300.60339571
59Vitamin digestion and absorption_Homo sapiens_hsa049770.59726414
60Serotonergic synapse_Homo sapiens_hsa047260.59008665
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57773018
62Circadian entrainment_Homo sapiens_hsa047130.56066112
63Metabolic pathways_Homo sapiens_hsa011000.55449981
64Cocaine addiction_Homo sapiens_hsa050300.55346332
65Asthma_Homo sapiens_hsa053100.54413992
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53592407
67Sulfur metabolism_Homo sapiens_hsa009200.51835101
68Systemic lupus erythematosus_Homo sapiens_hsa053220.49867655
69Nucleotide excision repair_Homo sapiens_hsa034200.49831037
70Wnt signaling pathway_Homo sapiens_hsa043100.47337916
71Hippo signaling pathway_Homo sapiens_hsa043900.45992088
72One carbon pool by folate_Homo sapiens_hsa006700.45762558
73ABC transporters_Homo sapiens_hsa020100.45584413
74beta-Alanine metabolism_Homo sapiens_hsa004100.45225917
75Alcoholism_Homo sapiens_hsa050340.44860044
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44760595
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41803596
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39620122
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.39213495
80Melanogenesis_Homo sapiens_hsa049160.38538658
81Insulin secretion_Homo sapiens_hsa049110.38490752
82Primary immunodeficiency_Homo sapiens_hsa053400.37748819
83Arachidonic acid metabolism_Homo sapiens_hsa005900.37446740
84Dopaminergic synapse_Homo sapiens_hsa047280.36720679
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36414195
86Mineral absorption_Homo sapiens_hsa049780.36111589
87Ether lipid metabolism_Homo sapiens_hsa005650.35139904
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34131775
89Glutathione metabolism_Homo sapiens_hsa004800.34119395
90Amphetamine addiction_Homo sapiens_hsa050310.33759538
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32653716
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.30613612
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29350993
94Axon guidance_Homo sapiens_hsa043600.28935052
95RNA transport_Homo sapiens_hsa030130.27724976
96Mismatch repair_Homo sapiens_hsa034300.27638720
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.27290649
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25601224
99Ovarian steroidogenesis_Homo sapiens_hsa049130.24764012
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.24551281

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