ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	8.06689402
2	ATP synthesis coupled proton transport (GO:0015986)	7.38034744
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	7.38034744
4	viral transcription (GO:0019083)	7.21605469
5	translational termination (GO:0006415)	6.88642759
6	sequestering of actin monomers (GO:0042989)	6.80732704
7	cotranslational protein targeting to membrane (GO:0006613)	6.00258970
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.97897996
9	behavioral response to nicotine (GO:0035095)	5.91144396
10	protein targeting to ER (GO:0045047)	5.90921065
11	neuron fate determination (GO:0048664)	5.85124810
12	ribosomal small subunit assembly (GO:0000028)	5.64706751
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.64387450
14	translational elongation (GO:0006414)	5.62852339
15	protein localization to endoplasmic reticulum (GO:0070972)	5.45061102
16	cellular protein complex disassembly (GO:0043624)	5.28281002
17	viral life cycle (GO:0019058)	5.20055326
18	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.17019365
19	maturation of SSU-rRNA (GO:0030490)	5.06412782
20	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.98242771
21	respiratory electron transport chain (GO:0022904)	4.93586017
22	ribosomal small subunit biogenesis (GO:0042274)	4.92956774
23	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.89058221
24	electron transport chain (GO:0022900)	4.87227778
25	epithelial cilium movement (GO:0003351)	4.84580188
26	translational initiation (GO:0006413)	4.56091524
27	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.54616101
28	protein complex disassembly (GO:0043241)	4.41698321
29	axonemal dynein complex assembly (GO:0070286)	4.39353316
30	protein complex biogenesis (GO:0070271)	4.33562502
31	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.31033997
32	NADH dehydrogenase complex assembly (GO:0010257)	4.31033997
33	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.31033997
34	chaperone-mediated protein transport (GO:0072321)	4.21446591
35	macromolecular complex disassembly (GO:0032984)	4.14543225
36	ATP biosynthetic process (GO:0006754)	4.14390395
37	mitochondrial respiratory chain complex assembly (GO:0033108)	4.10660317
38	cilium movement (GO:0003341)	4.04014479
39	protein targeting to membrane (GO:0006612)	3.85140814
40	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.73109680
41	protein neddylation (GO:0045116)	3.70988671
42	hydrogen ion transmembrane transport (GO:1902600)	3.69926663
43	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.68197114
44	spinal cord association neuron differentiation (GO:0021527)	3.58006999
45	protein polyglutamylation (GO:0018095)	3.44560658
46	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.42953517
47	proton transport (GO:0015992)	3.37962584
48	translation (GO:0006412)	3.32715927
49	hydrogen transport (GO:0006818)	3.29652317
50	ribosomal large subunit biogenesis (GO:0042273)	3.27563787
51	mRNA catabolic process (GO:0006402)	3.26213894
52	platelet dense granule organization (GO:0060155)	3.22237072
53	cell proliferation in forebrain (GO:0021846)	3.19334141
54	inner mitochondrial membrane organization (GO:0007007)	3.18021710
55	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.12349037
56	somite development (GO:0061053)	3.07515151
57	transmission of nerve impulse (GO:0019226)	3.05307604
58	protein-cofactor linkage (GO:0018065)	3.02949072
59	synaptic transmission, cholinergic (GO:0007271)	2.95495148
60	limb bud formation (GO:0060174)	2.89427505
61	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.86552936
62	RNA catabolic process (GO:0006401)	2.82042277
63	pyrimidine nucleobase catabolic process (GO:0006208)	2.81087235
64	retinal ganglion cell axon guidance (GO:0031290)	2.80224187
65	determination of left/right symmetry (GO:0007368)	2.80017449
66	nucleoside triphosphate biosynthetic process (GO:0009142)	2.79413582
67	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.67555309
68	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.67024790
69	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.65889557
70	intracellular protein transmembrane import (GO:0044743)	2.64762945
71	otic vesicle formation (GO:0030916)	2.64684487
72	cell differentiation in spinal cord (GO:0021515)	2.64194994
73	neuron fate specification (GO:0048665)	2.63490421
74	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.63342815
75	termination of RNA polymerase III transcription (GO:0006386)	2.63342815
76	DNA damage response, detection of DNA damage (GO:0042769)	2.63174883
77	determination of bilateral symmetry (GO:0009855)	2.56810630
78	DNA deamination (GO:0045006)	2.55845285
79	neuromuscular synaptic transmission (GO:0007274)	2.55516483
80	establishment of protein localization to membrane (GO:0090150)	2.54775393
81	specification of symmetry (GO:0009799)	2.52974354
82	neuronal stem cell maintenance (GO:0097150)	2.51057654
83	protein targeting (GO:0006605)	2.50087000
84	left/right pattern formation (GO:0060972)	2.50026083
85	cornea development in camera-type eye (GO:0061303)	2.47806140
86	midbrain development (GO:0030901)	2.43583397
87	spliceosomal complex assembly (GO:0000245)	2.42676751
88	GTP biosynthetic process (GO:0006183)	2.42387413
89	cellular component biogenesis (GO:0044085)	2.41548218
90	nephron epithelium morphogenesis (GO:0072088)	2.41381118
91	nephron tubule morphogenesis (GO:0072078)	2.41381118
92	cAMP catabolic process (GO:0006198)	2.40459583
93	somite rostral/caudal axis specification (GO:0032525)	2.39517960
94	positive regulation of fatty acid oxidation (GO:0046321)	2.38799468
95	establishment of protein localization to organelle (GO:0072594)	2.38352005
96	sulfation (GO:0051923)	2.36133201
97	heme transport (GO:0015886)	2.35736625
98	water-soluble vitamin biosynthetic process (GO:0042364)	2.35507501
99	dendritic spine morphogenesis (GO:0060997)	2.33865321
100	regulation of cilium movement (GO:0003352)	2.32783972

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.93870100
2	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.11917920
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.10661013
4	VDR_22108803_ChIP-Seq_LS180_Human	3.03133390
5	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.02606146
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.66095979
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.64756642
8	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.62805368
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.46863810
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.44056438
11	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.37510160
12	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.32611034
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.23817773
14	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.14148767
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.12470995
16	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.04024304
17	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.03337510
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.02269598
19	EWS_26573619_Chip-Seq_HEK293_Human	1.95600143
20	FUS_26573619_Chip-Seq_HEK293_Human	1.95077087
21	IGF1R_20145208_ChIP-Seq_DFB_Human	1.92340778
22	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.92125794
23	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.91694489
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.91658097
25	GBX2_23144817_ChIP-Seq_PC3_Human	1.90250398
26	RNF2_27304074_Chip-Seq_NSC_Mouse	1.85041192
27	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.83167778
28	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.81979372
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.79628205
30	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.76795845
31	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.74724962
32	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.66425980
33	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.66040062
34	IRF1_19129219_ChIP-ChIP_H3396_Human	1.62384872
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.61779059
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.61182736
37	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.61044006
38	P300_19829295_ChIP-Seq_ESCs_Human	1.57644022
39	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.56075621
40	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.55385146
41	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.55351324
42	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.53114089
43	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.47337302
44	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.46406008
45	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.46040208
46	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.45356691
47	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.45356691
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42321593
49	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.41716399
50	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.40604536
51	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.39628473
52	ELK1_19687146_ChIP-ChIP_HELA_Human	1.38473676
53	REST_21632747_ChIP-Seq_MESCs_Mouse	1.37009876
54	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.33851464
55	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.33146044
56	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.31005730
57	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.31005730
58	BCAT_22108803_ChIP-Seq_LS180_Human	1.28908137
59	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.28401447
60	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.26099244
61	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.25850068
62	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.21738824
63	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.20882646
64	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.19282784
65	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.17656820
66	TTF2_22483619_ChIP-Seq_HELA_Human	1.16321341
67	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.16205570
68	TP53_22573176_ChIP-Seq_HFKS_Human	1.14569915
69	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.14073028
70	VDR_23849224_ChIP-Seq_CD4+_Human	1.13881927
71	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.13047587
72	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.11026282
73	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.09889123
74	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.09532566
75	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.09166370
76	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.07025215
77	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.05992203
78	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.05987857
79	ER_23166858_ChIP-Seq_MCF-7_Human	1.05972043
80	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.05086089
81	NCOR_22424771_ChIP-Seq_293T_Human	1.04948458
82	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03932141
83	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.01664058
84	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.00594854
85	CBP_20019798_ChIP-Seq_JUKART_Human	1.00594854
86	AR_25329375_ChIP-Seq_VCAP_Human	0.99618691
87	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.96409780
88	SOX2_19829295_ChIP-Seq_ESCs_Human	0.96280215
89	NANOG_19829295_ChIP-Seq_ESCs_Human	0.96280215
90	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.94667138
91	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.94659089
92	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.92980543
93	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.92927306
94	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.91418080
95	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.91014066
96	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.90096520
97	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.89502198
98	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.89356039
99	TCF4_22108803_ChIP-Seq_LS180_Human	0.88931198
100	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.88601534

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.51612929
2	MP0002638_abnormal_pupillary_reflex	3.69059382
3	MP0006292_abnormal_olfactory_placode	2.89522742
4	MP0003136_yellow_coat_color	2.51332397
5	MP0002938_white_spotting	2.36527845
6	MP0004133_heterotaxia	2.31191301
7	MP0010030_abnormal_orbit_morphology	2.13023067
8	MP0003011_delayed_dark_adaptation	2.09102724
9	MP0000631_abnormal_neuroendocrine_gland	2.01955734
10	MP0004142_abnormal_muscle_tone	2.00967266
11	MP0003787_abnormal_imprinting	1.97497831
12	MP0004742_abnormal_vestibular_system	1.95948060
13	MP0000566_synostosis	1.95439601
14	MP0003283_abnormal_digestive_organ	1.91563031
15	MP0005645_abnormal_hypothalamus_physiol	1.86153870
16	MP0006276_abnormal_autonomic_nervous	1.83415361
17	MP0006072_abnormal_retinal_apoptosis	1.83232145
18	MP0004885_abnormal_endolymph	1.82248271
19	MP0005084_abnormal_gallbladder_morpholo	1.81496350
20	MP0001986_abnormal_taste_sensitivity	1.67900234
21	MP0008877_abnormal_DNA_methylation	1.66719904
22	MP0000778_abnormal_nervous_system	1.65151620
23	MP0005551_abnormal_eye_electrophysiolog	1.62832196
24	MP0001529_abnormal_vocalization	1.62102466
25	MP0000026_abnormal_inner_ear	1.61420141
26	MP0001485_abnormal_pinna_reflex	1.54912834
27	MP0009745_abnormal_behavioral_response	1.52484372
28	MP0002272_abnormal_nervous_system	1.50049253
29	MP0009046_muscle_twitch	1.47858867
30	MP0002734_abnormal_mechanical_nocicepti	1.46612415
31	MP0005646_abnormal_pituitary_gland	1.46254144
32	MP0002653_abnormal_ependyma_morphology	1.45942464
33	MP0000049_abnormal_middle_ear	1.43974602
34	MP0003938_abnormal_ear_development	1.43188172
35	MP0001968_abnormal_touch/_nociception	1.42186055
36	MP0002928_abnormal_bile_duct	1.41852994
37	MP0002277_abnormal_respiratory_mucosa	1.41531272
38	MP0005253_abnormal_eye_physiology	1.40670577
39	MP0002735_abnormal_chemical_nociception	1.39835971
40	MP0004145_abnormal_muscle_electrophysio	1.34338831
41	MP0001286_abnormal_eye_development	1.32937610
42	MP0002095_abnormal_skin_pigmentation	1.32553991
43	MP0002752_abnormal_somatic_nervous	1.31556607
44	MP0008875_abnormal_xenobiotic_pharmacok	1.31313129
45	MP0002163_abnormal_gland_morphology	1.30456136
46	MP0003122_maternal_imprinting	1.30334350
47	MP0003880_abnormal_central_pattern	1.29738536
48	MP0002736_abnormal_nociception_after	1.29561691
49	MP0005195_abnormal_posterior_eye	1.29213674
50	MP0001293_anophthalmia	1.26403283
51	MP0002184_abnormal_innervation	1.26347444
52	MP0002557_abnormal_social/conspecific_i	1.23985111
53	MP0001440_abnormal_grooming_behavior	1.21903365
54	MP0003195_calcinosis	1.21827257
55	MP0004147_increased_porphyrin_level	1.21391845
56	MP0001970_abnormal_pain_threshold	1.21115084
57	MP0003121_genomic_imprinting	1.20696270
58	MP0005423_abnormal_somatic_nervous	1.20213185
59	MP0008872_abnormal_physiological_respon	1.19779139
60	MP0001905_abnormal_dopamine_level	1.18412404
61	MP0003937_abnormal_limbs/digits/tail_de	1.16489482
62	MP0005171_absent_coat_pigmentation	1.13910009
63	MP0008995_early_reproductive_senescence	1.13751194
64	MP0009250_abnormal_appendicular_skeleto	1.09484136
65	MP0002572_abnormal_emotion/affect_behav	1.08607089
66	MP0001984_abnormal_olfaction	1.08145837
67	MP0003119_abnormal_digestive_system	1.06273190
68	MP0002138_abnormal_hepatobiliary_system	1.04775180
69	MP0000955_abnormal_spinal_cord	1.03588158
70	MP0002160_abnormal_reproductive_system	1.02799887
71	MP0002064_seizures	1.01950402
72	MP0002733_abnormal_thermal_nociception	0.98268832
73	MP0002139_abnormal_hepatobiliary_system	0.96370814
74	MP0002876_abnormal_thyroid_physiology	0.96226009
75	MP0008789_abnormal_olfactory_epithelium	0.95754527
76	MP0002882_abnormal_neuron_morphology	0.95213815
77	MP0004019_abnormal_vitamin_homeostasis	0.94464508
78	MP0002751_abnormal_autonomic_nervous	0.92617511
79	MP0003878_abnormal_ear_physiology	0.91847980
80	MP0005377_hearing/vestibular/ear_phenot	0.91847980
81	MP0001324_abnormal_eye_pigmentation	0.90867692
82	MP0003635_abnormal_synaptic_transmissio	0.90624587
83	MP0003646_muscle_fatigue	0.90218965
84	MP0005391_vision/eye_phenotype	0.89974625
85	MP0003942_abnormal_urinary_system	0.89351629
86	MP0002067_abnormal_sensory_capabilities	0.89159855
87	MP0002697_abnormal_eye_size	0.88245086
88	MP0000372_irregular_coat_pigmentation	0.86097693
89	MP0005389_reproductive_system_phenotype	0.85012185
90	MP0003861_abnormal_nervous_system	0.84500511
91	MP0000647_abnormal_sebaceous_gland	0.83450926
92	MP0010386_abnormal_urinary_bladder	0.83268033
93	MP0001486_abnormal_startle_reflex	0.81090607
94	MP0001919_abnormal_reproductive_system	0.78000574
95	MP0002152_abnormal_brain_morphology	0.76263309
96	MP0002063_abnormal_learning/memory/cond	0.75667058
97	MP0002837_dystrophic_cardiac_calcinosis	0.75312488
98	MP0005379_endocrine/exocrine_gland_phen	0.74333321
99	MP0001963_abnormal_hearing_physiology	0.73930527
100	MP0005394_taste/olfaction_phenotype	0.73475599

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased hepatocellular lipid droplets (HP:0006565)	4.98305251
2	Lipid accumulation in hepatocytes (HP:0006561)	4.63277852
3	Acute necrotizing encephalopathy (HP:0006965)	4.57595001
4	Abnormality of cells of the erythroid lineage (HP:0012130)	4.43805810
5	Congenital, generalized hypertrichosis (HP:0004540)	4.12937000
6	Abnormal number of erythroid precursors (HP:0012131)	4.12635489
7	Mitochondrial inheritance (HP:0001427)	4.09797094
8	Renal Fanconi syndrome (HP:0001994)	4.04704422
9	Abnormal mitochondria in muscle tissue (HP:0008316)	4.00313167
10	Acute encephalopathy (HP:0006846)	3.94406473
11	Abnormal ciliary motility (HP:0012262)	3.80758011
12	Reticulocytopenia (HP:0001896)	3.77946175
13	Molar tooth sign on MRI (HP:0002419)	3.72364210
14	Abnormality of midbrain morphology (HP:0002418)	3.72364210
15	Progressive macrocephaly (HP:0004481)	3.68988631
16	Abnormal respiratory motile cilium physiology (HP:0012261)	3.61340004
17	Macrocytic anemia (HP:0001972)	3.58331093
18	Increased CSF lactate (HP:0002490)	3.45532083
19	True hermaphroditism (HP:0010459)	3.36601290
20	Pancreatic fibrosis (HP:0100732)	3.33292150
21	Exertional dyspnea (HP:0002875)	3.29496280
22	Pancreatic cysts (HP:0001737)	3.25754907
23	Abnormal respiratory epithelium morphology (HP:0012253)	3.13324791
24	Abnormal respiratory motile cilium morphology (HP:0005938)	3.13324791
25	Increased intramyocellular lipid droplets (HP:0012240)	3.07154345
26	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.05033170
27	Concave nail (HP:0001598)	2.96309675
28	Pallor (HP:0000980)	2.93884448
29	Nephronophthisis (HP:0000090)	2.89787478
30	Myokymia (HP:0002411)	2.84879240
31	Glycosuria (HP:0003076)	2.81757983
32	Abnormality of urine glucose concentration (HP:0011016)	2.81757983
33	Rhinitis (HP:0012384)	2.80998786
34	3-Methylglutaconic aciduria (HP:0003535)	2.80081561
35	Abnormality of renal resorption (HP:0011038)	2.77673013
36	Medial flaring of the eyebrow (HP:0010747)	2.75368115
37	Congenital stationary night blindness (HP:0007642)	2.74348142
38	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.64497105
39	Hepatocellular necrosis (HP:0001404)	2.62354202
40	Increased muscle lipid content (HP:0009058)	2.58846695
41	Cerebral edema (HP:0002181)	2.56272374
42	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.53543594
43	Septo-optic dysplasia (HP:0100842)	2.53383194
44	Abnormality of the renal medulla (HP:0100957)	2.43579427
45	Stenosis of the external auditory canal (HP:0000402)	2.39562383
46	Hyperphosphaturia (HP:0003109)	2.34457633
47	Optic disc pallor (HP:0000543)	2.34314743
48	Chronic sinusitis (HP:0011109)	2.32820266
49	Respiratory difficulties (HP:0002880)	2.30662423
50	Anencephaly (HP:0002323)	2.29684001
51	Limb dystonia (HP:0002451)	2.28145088
52	Hepatic necrosis (HP:0002605)	2.27779309
53	Pendular nystagmus (HP:0012043)	2.26997965
54	Leukodystrophy (HP:0002415)	2.20083551
55	Sclerocornea (HP:0000647)	2.16386906
56	Cystic liver disease (HP:0006706)	2.14697448
57	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.14159708
58	Absent/shortened dynein arms (HP:0200106)	2.14159708
59	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.12152144
60	Gait imbalance (HP:0002141)	2.09856605
61	Chronic hepatic failure (HP:0100626)	2.08756242
62	Agitation (HP:0000713)	2.05783609
63	Polyphagia (HP:0002591)	2.05363537
64	Partial duplication of the phalanx of hand (HP:0009999)	2.00959013
65	Ulnar claw (HP:0001178)	2.00840142
66	Lactic acidosis (HP:0003128)	2.00648640
67	Nephrogenic diabetes insipidus (HP:0009806)	1.98717720
68	Abnormal drinking behavior (HP:0030082)	1.97886875
69	Polydipsia (HP:0001959)	1.97886875
70	Abnormality of the pons (HP:0007361)	1.97257166
71	Abnormal urine phosphate concentration (HP:0012599)	1.96053450
72	Congenital primary aphakia (HP:0007707)	1.95778800
73	Increased serum lactate (HP:0002151)	1.95532065
74	Rib fusion (HP:0000902)	1.94909045
75	Hypoplasia of the pons (HP:0012110)	1.93761032
76	Male pseudohermaphroditism (HP:0000037)	1.93282410
77	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.92726441
78	Exercise intolerance (HP:0003546)	1.91900573
79	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.90421783
80	Abnormality of the labia minora (HP:0012880)	1.90402985
81	Lissencephaly (HP:0001339)	1.88582891
82	Polyuria (HP:0000103)	1.85713607
83	Decreased central vision (HP:0007663)	1.83581514
84	Depressed nasal ridge (HP:0000457)	1.82100276
85	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.82018062
86	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.82018062
87	Genital tract atresia (HP:0001827)	1.81299225
88	Furrowed tongue (HP:0000221)	1.81222190
89	Abnormal biliary tract physiology (HP:0012439)	1.80354903
90	Bile duct proliferation (HP:0001408)	1.80354903
91	Vaginal atresia (HP:0000148)	1.79690101
92	Abnormal rod and cone electroretinograms (HP:0008323)	1.77489091
93	Increased corneal curvature (HP:0100692)	1.77006521
94	Keratoconus (HP:0000563)	1.77006521
95	Respiratory failure (HP:0002878)	1.73455759
96	Type II lissencephaly (HP:0007260)	1.72839952
97	Thyroid-stimulating hormone excess (HP:0002925)	1.67157385
98	Absent septum pellucidum (HP:0001331)	1.65378383
99	Abnormality of the renal cortex (HP:0011035)	1.64509130
100	Occipital encephalocele (HP:0002085)	1.64081371

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	3.21199933
2	TAF1	2.69154203
3	VRK2	2.54499991
4	GRK1	2.44161388
5	PNCK	2.36438673
6	DYRK2	2.27349077
7	NUAK1	2.26853149
8	EPHB2	2.19739379
9	MAPK15	2.18614110
10	VRK1	2.18362670
11	ADRBK2	2.15034252
12	WNK3	2.14862131
13	PASK	2.10756492
14	ZAK	1.88760373
15	WNK4	1.86685983
16	MARK1	1.85205822
17	NTRK3	1.71398579
18	CDK19	1.68589906
19	MAP3K4	1.66905090
20	MAP2K7	1.65904981
21	CASK	1.65561180
22	WEE1	1.59516454
23	PINK1	1.58757700
24	BMPR1B	1.51132469
25	STK16	1.50169313
26	INSRR	1.50085850
27	OXSR1	1.48973835
28	MAPK13	1.46157918
29	DYRK3	1.44763298
30	BUB1	1.44727585
31	PIK3CA	1.36365920
32	STK39	1.25843979
33	TGFBR1	1.24306159
34	PRKCG	1.22181378
35	FRK	1.02480550
36	TIE1	1.02351072
37	MINK1	1.00465273
38	CDC7	0.97943999
39	TXK	0.96298433
40	PAK3	0.94119543
41	NTRK2	0.93726333
42	LRRK2	0.93553752
43	ADRBK1	0.91799422
44	PLK3	0.87622774
45	MAP3K9	0.86731402
46	NME1	0.83063966
47	TSSK6	0.82617726
48	MAP3K12	0.80940237
49	BRAF	0.79270524
50	SIK2	0.78346069
51	CSNK1G2	0.77246152
52	PKN1	0.75371712
53	MAP2K4	0.75100623
54	NEK2	0.71488455
55	PLK4	0.70064943
56	PRKCE	0.68918789
57	MST4	0.68245435
58	MAP4K2	0.67161174
59	STK24	0.66193656
60	CCNB1	0.65926396
61	FGFR2	0.65602719
62	PRKACA	0.65034090
63	STK11	0.64407660
64	TNIK	0.63856345
65	DYRK1A	0.62441574
66	PRKG1	0.60974254
67	DYRK1B	0.59714657
68	PRKCQ	0.58726409
69	EPHA4	0.57884928
70	PLK2	0.57761312
71	CSNK2A2	0.56655049
72	BCKDK	0.56153211
73	OBSCN	0.54892559
74	ERBB2	0.54796014
75	CSNK2A1	0.54559849
76	CDK3	0.53622507
77	RPS6KA5	0.52434386
78	MAPKAPK5	0.52356105
79	CHEK2	0.51949593
80	AURKB	0.50445765
81	UHMK1	0.50210700
82	CSNK1E	0.49613848
83	DAPK3	0.49418821
84	CAMK2A	0.48282561
85	ERBB3	0.48028845
86	TRIM28	0.47975001
87	SGK223	0.47937078
88	SGK494	0.47937078
89	CDK8	0.47462369
90	CSNK1G3	0.46573278
91	TAOK3	0.45140437
92	AURKA	0.44819043
93	PHKG2	0.44678215
94	PHKG1	0.44678215
95	RPS6KA6	0.44192609
96	MKNK2	0.40475672
97	MUSK	0.39157869
98	MKNK1	0.39106144
99	BCR	0.38683506
100	ACVR1B	0.37325973

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.61757782
2	Oxidative phosphorylation_Homo sapiens_hsa00190	5.17708173
3	Parkinsons disease_Homo sapiens_hsa05012	4.34544965
4	Alzheimers disease_Homo sapiens_hsa05010	3.05813001
5	Protein export_Homo sapiens_hsa03060	3.03730225
6	Huntingtons disease_Homo sapiens_hsa05016	3.02535174
7	Cardiac muscle contraction_Homo sapiens_hsa04260	2.82488879
8	Proteasome_Homo sapiens_hsa03050	2.80015627
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.74927524
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.13956808
11	RNA polymerase_Homo sapiens_hsa03020	2.03685297
12	Phototransduction_Homo sapiens_hsa04744	1.96498405
13	Nicotine addiction_Homo sapiens_hsa05033	1.88806535
14	Butanoate metabolism_Homo sapiens_hsa00650	1.80095698
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.63389539
16	Basal cell carcinoma_Homo sapiens_hsa05217	1.54901514
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.51230830
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.50120445
19	Caffeine metabolism_Homo sapiens_hsa00232	1.40638653
20	Basal transcription factors_Homo sapiens_hsa03022	1.30977845
21	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.21529602
22	Sulfur relay system_Homo sapiens_hsa04122	1.19182256
23	Homologous recombination_Homo sapiens_hsa03440	1.18969729
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.18662448
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.17898619
26	RNA degradation_Homo sapiens_hsa03018	1.15326893
27	Morphine addiction_Homo sapiens_hsa05032	1.11146819
28	Olfactory transduction_Homo sapiens_hsa04740	1.10110318
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.09445568
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.03174570
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00602662
32	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.98408279
33	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.95371508
34	Taste transduction_Homo sapiens_hsa04742	0.93423393
35	Collecting duct acid secretion_Homo sapiens_hsa04966	0.88105971
36	Folate biosynthesis_Homo sapiens_hsa00790	0.87864732
37	Purine metabolism_Homo sapiens_hsa00230	0.87609293
38	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.84806976
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79096851
40	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.76880781
41	Steroid biosynthesis_Homo sapiens_hsa00100	0.75429230
42	GABAergic synapse_Homo sapiens_hsa04727	0.73878704
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71021158
44	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.70884645
45	Fanconi anemia pathway_Homo sapiens_hsa03460	0.70857880
46	Spliceosome_Homo sapiens_hsa03040	0.68172274
47	Peroxisome_Homo sapiens_hsa04146	0.67316881
48	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.66434407
49	Selenocompound metabolism_Homo sapiens_hsa00450	0.66135004
50	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.66083239
51	Propanoate metabolism_Homo sapiens_hsa00640	0.65348974
52	Pyrimidine metabolism_Homo sapiens_hsa00240	0.63914586
53	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.61673418
54	Glutamatergic synapse_Homo sapiens_hsa04724	0.61567830
55	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.61386350
56	Pyruvate metabolism_Homo sapiens_hsa00620	0.60682273
57	Fat digestion and absorption_Homo sapiens_hsa04975	0.60558819
58	Retinol metabolism_Homo sapiens_hsa00830	0.60339571
59	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.59726414
60	Serotonergic synapse_Homo sapiens_hsa04726	0.59008665
61	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.57773018
62	Circadian entrainment_Homo sapiens_hsa04713	0.56066112
63	Metabolic pathways_Homo sapiens_hsa01100	0.55449981
64	Cocaine addiction_Homo sapiens_hsa05030	0.55346332
65	Asthma_Homo sapiens_hsa05310	0.54413992
66	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.53592407
67	Sulfur metabolism_Homo sapiens_hsa00920	0.51835101
68	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.49867655
69	Nucleotide excision repair_Homo sapiens_hsa03420	0.49831037
70	Wnt signaling pathway_Homo sapiens_hsa04310	0.47337916
71	Hippo signaling pathway_Homo sapiens_hsa04390	0.45992088
72	One carbon pool by folate_Homo sapiens_hsa00670	0.45762558
73	ABC transporters_Homo sapiens_hsa02010	0.45584413
74	beta-Alanine metabolism_Homo sapiens_hsa00410	0.45225917
75	Alcoholism_Homo sapiens_hsa05034	0.44860044
76	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.44760595
77	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.41803596
78	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.39620122
79	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.39213495
80	Melanogenesis_Homo sapiens_hsa04916	0.38538658
81	Insulin secretion_Homo sapiens_hsa04911	0.38490752
82	Primary immunodeficiency_Homo sapiens_hsa05340	0.37748819
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.37446740
84	Dopaminergic synapse_Homo sapiens_hsa04728	0.36720679
85	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.36414195
86	Mineral absorption_Homo sapiens_hsa04978	0.36111589
87	Ether lipid metabolism_Homo sapiens_hsa00565	0.35139904
88	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.34131775
89	Glutathione metabolism_Homo sapiens_hsa00480	0.34119395
90	Amphetamine addiction_Homo sapiens_hsa05031	0.33759538
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.32653716
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.30613612
93	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.29350993
94	Axon guidance_Homo sapiens_hsa04360	0.28935052
95	RNA transport_Homo sapiens_hsa03013	0.27724976
96	Mismatch repair_Homo sapiens_hsa03430	0.27638720
97	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.27290649
98	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.25601224
99	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.24764012
100	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.24551281

RPL26P30

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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