ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cytidine metabolic process (GO:0046087)	6.41317038
2	cytidine catabolic process (GO:0006216)	6.41317038
3	cytidine deamination (GO:0009972)	6.41317038
4	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	6.34065773
5	ribosomal small subunit assembly (GO:0000028)	6.19011228
6	DNA deamination (GO:0045006)	6.01881386
7	pyrimidine ribonucleoside catabolic process (GO:0046133)	5.70510982
8	viral transcription (GO:0019083)	5.65691027
9	translational termination (GO:0006415)	5.45781708
10	ATP synthesis coupled proton transport (GO:0015986)	5.08759424
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.08759424
12	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.03568126
13	maturation of SSU-rRNA (GO:0030490)	4.90076969
14	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.82144766
15	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.78325040
16	cotranslational protein targeting to membrane (GO:0006613)	4.76168747
17	protein targeting to ER (GO:0045047)	4.76165156
18	translational elongation (GO:0006414)	4.61775253
19	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.54954523
20	ribosomal small subunit biogenesis (GO:0042274)	4.45096964
21	protein localization to endoplasmic reticulum (GO:0070972)	4.44016685
22	negative regulation by host of viral transcription (GO:0043922)	4.36493919
23	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.22353101
24	cellular protein complex disassembly (GO:0043624)	4.12783814
25	viral life cycle (GO:0019058)	4.03236661
26	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.84911794
27	electron transport chain (GO:0022900)	3.71769930
28	respiratory electron transport chain (GO:0022904)	3.70708197
29	GPI anchor biosynthetic process (GO:0006506)	3.68385134
30	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.67701296
31	behavioral response to nicotine (GO:0035095)	3.67074058
32	protein neddylation (GO:0045116)	3.64040745
33	GPI anchor metabolic process (GO:0006505)	3.57018564
34	translational initiation (GO:0006413)	3.53902678
35	protein complex biogenesis (GO:0070271)	3.51752189
36	response to pheromone (GO:0019236)	3.47263659
37	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.41725236
38	positive regulation of T cell apoptotic process (GO:0070234)	3.40175064
39	protein complex disassembly (GO:0043241)	3.36585137
40	positive regulation of interleukin-8 secretion (GO:2000484)	3.35858106
41	cell proliferation in forebrain (GO:0021846)	3.27568487
42	translation (GO:0006412)	3.21401751
43	regulation of activation of Janus kinase activity (GO:0010533)	3.20386366
44	ribosomal large subunit biogenesis (GO:0042273)	3.19902297
45	macromolecular complex disassembly (GO:0032984)	3.16168856
46	protein targeting to membrane (GO:0006612)	3.10540022
47	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	3.09821874
48	axonemal dynein complex assembly (GO:0070286)	3.09001860
49	DNA demethylation (GO:0080111)	3.08036690
50	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.03580213
51	termination of RNA polymerase III transcription (GO:0006386)	3.03580213
52	neuron fate determination (GO:0048664)	3.02216464
53	mannosylation (GO:0097502)	3.01714707
54	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.00601981
55	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.00601981
56	NADH dehydrogenase complex assembly (GO:0010257)	3.00601981
57	mitochondrial respiratory chain complex assembly (GO:0033108)	2.98746211
58	pyrimidine nucleotide catabolic process (GO:0006244)	2.96339818
59	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.96098549
60	ATP biosynthetic process (GO:0006754)	2.95146735
61	regulation of B cell receptor signaling pathway (GO:0050855)	2.94531352
62	L-fucose catabolic process (GO:0042355)	2.90699061
63	fucose catabolic process (GO:0019317)	2.90699061
64	L-fucose metabolic process (GO:0042354)	2.90699061
65	regulation of interleukin-8 secretion (GO:2000482)	2.90117695
66	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.89047401
67	preassembly of GPI anchor in ER membrane (GO:0016254)	2.88731327
68	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.85527548
69	pseudouridine synthesis (GO:0001522)	2.82068050
70	regulation of regulatory T cell differentiation (GO:0045589)	2.81746197
71	hydrogen ion transmembrane transport (GO:1902600)	2.81365595
72	rRNA catabolic process (GO:0016075)	2.81205413
73	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.80905306
74	positive regulation of defense response to virus by host (GO:0002230)	2.80151491
75	pyrimidine nucleoside catabolic process (GO:0046135)	2.79172686
76	protein-cofactor linkage (GO:0018065)	2.79045320
77	platelet dense granule organization (GO:0060155)	2.78572080
78	somite development (GO:0061053)	2.77093306
79	otic vesicle formation (GO:0030916)	2.76007044
80	pyrimidine-containing compound catabolic process (GO:0072529)	2.73274658
81	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.72672653
82	positive regulation of calcium-mediated signaling (GO:0050850)	2.69225799
83	nonmotile primary cilium assembly (GO:0035058)	2.68682655
84	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.67792378
85	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.67792378
86	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.65314154
87	mRNA catabolic process (GO:0006402)	2.65284371
88	protein peptidyl-prolyl isomerization (GO:0000413)	2.64624260
89	cellular response to interferon-beta (GO:0035458)	2.62027168
90	iron-sulfur cluster assembly (GO:0016226)	2.61143113
91	metallo-sulfur cluster assembly (GO:0031163)	2.61143113
92	proteasome assembly (GO:0043248)	2.59892384
93	regulation of cellular amino acid metabolic process (GO:0006521)	2.59491426
94	thalamus development (GO:0021794)	2.59279989
95	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.58375875
96	regulation of T cell receptor signaling pathway (GO:0050856)	2.53333639
97	axoneme assembly (GO:0035082)	2.52952771
98	positive regulation of cell fate commitment (GO:0010455)	2.51750509
99	sequestering of actin monomers (GO:0042989)	2.51340921
100	proton transport (GO:0015992)	2.50981706

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.72571426
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.84779294
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.65242090
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.52209445
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.33357852
6	VDR_22108803_ChIP-Seq_LS180_Human	3.19997061
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.12883666
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.68796376
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.54078824
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.48696020
11	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.46348972
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.24057000
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.23695137
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.15082359
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.08792311
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.05871523
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.99097868
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.91945299
19	MYC_18940864_ChIP-ChIP_HL60_Human	1.88634303
20	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.83613089
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.80674491
22	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.79532868
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.79317910
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.74762738
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.72730402
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.72149559
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.60328701
28	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.56239660
29	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.55622091
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.54740443
31	IGF1R_20145208_ChIP-Seq_DFB_Human	1.54485188
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.53301058
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.52438674
34	NANOG_20526341_ChIP-Seq_ESCs_Human	1.51605863
35	FUS_26573619_Chip-Seq_HEK293_Human	1.51317146
36	FOXP3_21729870_ChIP-Seq_TREG_Human	1.44109828
37	EWS_26573619_Chip-Seq_HEK293_Human	1.44068787
38	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.42675539
39	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.41779408
40	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.39881379
41	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.38849520
42	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.38849520
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36458363
44	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.31153388
45	AR_20517297_ChIP-Seq_VCAP_Human	1.29507494
46	IRF1_19129219_ChIP-ChIP_H3396_Human	1.28308287
47	NCOR_22424771_ChIP-Seq_293T_Human	1.27140828
48	P300_19829295_ChIP-Seq_ESCs_Human	1.26607836
49	AR_21572438_ChIP-Seq_LNCaP_Human	1.25460151
50	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.22623163
51	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.22036975
52	RUNX_20019798_ChIP-Seq_JUKART_Human	1.21888014
53	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.21728545
54	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21728121
55	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21093584
56	HTT_18923047_ChIP-ChIP_STHdh_Human	1.21060771
57	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.20664097
58	RNF2_27304074_Chip-Seq_NSC_Mouse	1.19803001
59	ER_23166858_ChIP-Seq_MCF-7_Human	1.18501563
60	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.17526146
61	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.17256834
62	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.16089253
63	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.15205772
64	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.14168749
65	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.13622415
66	CBP_20019798_ChIP-Seq_JUKART_Human	1.13622415
67	ERA_21632823_ChIP-Seq_H3396_Human	1.13451559
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12815206
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12815206
70	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.12431273
71	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.12404258
72	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.12360206
73	GATA3_26560356_Chip-Seq_TH2_Human	1.11077618
74	ERG_20517297_ChIP-Seq_VCAP_Human	1.10124706
75	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.09832304
76	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.09438377
77	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.09155178
78	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.08838208
79	GBX2_23144817_ChIP-Seq_PC3_Human	1.08240365
80	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06283407
81	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.06117566
82	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.04826087
83	MYC_19829295_ChIP-Seq_ESCs_Human	1.02478664
84	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.01568580
85	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.98585532
86	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.98107876
87	TAF2_19829295_ChIP-Seq_ESCs_Human	0.96708099
88	HOXB7_26014856_ChIP-Seq_BT474_Human	0.96449329
89	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.96095470
90	P53_21459846_ChIP-Seq_SAOS-2_Human	0.96046721
91	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.95368131
92	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.93250633
93	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.93045731
94	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.92679389
95	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.92611277
96	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.91349327
97	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91123685
98	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.91118667
99	MYB_26560356_Chip-Seq_TH2_Human	0.90960380
100	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.89616495

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.11067850
2	MP0006292_abnormal_olfactory_placode	3.73829921
3	MP0004147_increased_porphyrin_level	3.09046015
4	MP0002102_abnormal_ear_morphology	3.06914461
5	MP0005671_abnormal_response_to	3.04681389
6	MP0002638_abnormal_pupillary_reflex	2.86748141
7	MP0003878_abnormal_ear_physiology	2.53251781
8	MP0005377_hearing/vestibular/ear_phenot	2.53251781
9	MP0002653_abnormal_ependyma_morphology	2.50467631
10	MP0004142_abnormal_muscle_tone	2.03294948
11	MP0008877_abnormal_DNA_methylation	1.99128350
12	MP0009333_abnormal_splenocyte_physiolog	1.98792209
13	MP0005646_abnormal_pituitary_gland	1.88114164
14	MP0003122_maternal_imprinting	1.86311501
15	MP0008789_abnormal_olfactory_epithelium	1.80132202
16	MP0004885_abnormal_endolymph	1.79466929
17	MP0002234_abnormal_pharynx_morphology	1.68141937
18	MP0005084_abnormal_gallbladder_morpholo	1.66499089
19	MP0005075_abnormal_melanosome_morpholog	1.63356813
20	MP0009785_altered_susceptibility_to	1.59170281
21	MP0004742_abnormal_vestibular_system	1.57521774
22	MP0001919_abnormal_reproductive_system	1.56946337
23	MP0002837_dystrophic_cardiac_calcinosis	1.55651021
24	MP0003646_muscle_fatigue	1.55643915
25	MP0002095_abnormal_skin_pigmentation	1.52445426
26	MP0000049_abnormal_middle_ear	1.50512620
27	MP0001485_abnormal_pinna_reflex	1.47450640
28	MP0005389_reproductive_system_phenotype	1.43120306
29	MP0003195_calcinosis	1.42412989
30	MP0001188_hyperpigmentation	1.40416649
31	MP0000685_abnormal_immune_system	1.36415295
32	MP0005551_abnormal_eye_electrophysiolog	1.35515500
33	MP0006072_abnormal_retinal_apoptosis	1.35385666
34	MP0003283_abnormal_digestive_organ	1.32323011
35	MP0001293_anophthalmia	1.29363972
36	MP0000372_irregular_coat_pigmentation	1.28519253
37	MP0002277_abnormal_respiratory_mucosa	1.22895648
38	MP0008872_abnormal_physiological_respon	1.20843114
39	MP0005499_abnormal_olfactory_system	1.18610457
40	MP0005394_taste/olfaction_phenotype	1.18610457
41	MP0003011_delayed_dark_adaptation	1.18521909
42	MP0002148_abnormal_hypersensitivity_rea	1.17350862
43	MP0003787_abnormal_imprinting	1.15003195
44	MP0002160_abnormal_reproductive_system	1.14436046
45	MP0000026_abnormal_inner_ear	1.14038113
46	MP0001963_abnormal_hearing_physiology	1.13892669
47	MP0000631_abnormal_neuroendocrine_gland	1.13002259
48	MP0001440_abnormal_grooming_behavior	1.11235754
49	MP0003567_abnormal_fetal_cardiomyocyte	1.09898993
50	MP0003880_abnormal_central_pattern	1.09696839
51	MP0001800_abnormal_humoral_immune	1.09395944
52	MP0002272_abnormal_nervous_system	1.09358327
53	MP0001905_abnormal_dopamine_level	1.08080851
54	MP0001286_abnormal_eye_development	1.07911339
55	MP0001835_abnormal_antigen_presentation	1.06109333
56	MP0002163_abnormal_gland_morphology	1.06075946
57	MP0009745_abnormal_behavioral_response	1.05315538
58	MP0001968_abnormal_touch/_nociception	1.00435969
59	MP0002723_abnormal_immune_serum	1.00174655
60	MP0002876_abnormal_thyroid_physiology	1.00102697
61	MP0001486_abnormal_startle_reflex	0.99445210
62	MP0005195_abnormal_posterior_eye	0.99329023
63	MP0005387_immune_system_phenotype	0.98736802
64	MP0001790_abnormal_immune_system	0.98736802
65	MP0000569_abnormal_digit_pigmentation	0.96631486
66	MP0002938_white_spotting	0.95343244
67	MP0002752_abnormal_somatic_nervous	0.94954296
68	MP0003136_yellow_coat_color	0.94494243
69	MP0003937_abnormal_limbs/digits/tail_de	0.92494549
70	MP0002736_abnormal_nociception_after	0.92205038
71	MP0005174_abnormal_tail_pigmentation	0.89863549
72	MP0008875_abnormal_xenobiotic_pharmacok	0.89763373
73	MP0003121_genomic_imprinting	0.89584509
74	MP0006276_abnormal_autonomic_nervous	0.88455549
75	MP0002249_abnormal_larynx_morphology	0.87689633
76	MP0001529_abnormal_vocalization	0.86454148
77	MP0001984_abnormal_olfaction	0.86012994
78	MP0005645_abnormal_hypothalamus_physiol	0.85359490
79	MP0002751_abnormal_autonomic_nervous	0.84395248
80	MP0000778_abnormal_nervous_system	0.83304256
81	MP0005025_abnormal_response_to	0.83232292
82	MP0005000_abnormal_immune_tolerance	0.82954685
83	MP0002420_abnormal_adaptive_immunity	0.82823462
84	MP0002928_abnormal_bile_duct	0.82733697
85	MP0008058_abnormal_DNA_repair	0.81723054
86	MP0003763_abnormal_thymus_physiology	0.81583995
87	MP0001853_heart_inflammation	0.81043711
88	MP0001819_abnormal_immune_cell	0.79891877
89	MP0005636_abnormal_mineral_homeostasis	0.79038528
90	MP0008995_early_reproductive_senescence	0.78195035
91	MP0002233_abnormal_nose_morphology	0.76340534
92	MP0003938_abnormal_ear_development	0.75347706
93	MP0002067_abnormal_sensory_capabilities	0.74179628
94	MP0002557_abnormal_social/conspecific_i	0.73897591
95	MP0010030_abnormal_orbit_morphology	0.73120302
96	MP0004133_heterotaxia	0.72981877
97	MP0002184_abnormal_innervation	0.71890732
98	MP0002733_abnormal_thermal_nociception	0.71185905
99	MP0002405_respiratory_system_inflammati	0.69852088
100	MP0000716_abnormal_immune_system	0.66616879

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.07982095
2	Reticulocytopenia (HP:0001896)	3.89651557
3	Type II lissencephaly (HP:0007260)	3.87909362
4	Abnormality of cells of the erythroid lineage (HP:0012130)	3.74582461
5	Cerebellar dysplasia (HP:0007033)	3.56575536
6	Mitochondrial inheritance (HP:0001427)	3.53793257
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.43609538
8	Acute encephalopathy (HP:0006846)	3.36486737
9	Increased hepatocellular lipid droplets (HP:0006565)	3.31131217
10	Elevated erythrocyte sedimentation rate (HP:0003565)	3.25842246
11	IgG deficiency (HP:0004315)	3.23013491
12	Progressive macrocephaly (HP:0004481)	3.21342346
13	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.18764786
14	Absent/shortened dynein arms (HP:0200106)	3.18764786
15	Lipid accumulation in hepatocytes (HP:0006561)	3.17780588
16	Increased CSF lactate (HP:0002490)	3.16725851
17	3-Methylglutaconic aciduria (HP:0003535)	2.99512866
18	Macrocytic anemia (HP:0001972)	2.97466139
19	Pallor (HP:0000980)	2.93979256
20	True hermaphroditism (HP:0010459)	2.92028712
21	Abnormality of midbrain morphology (HP:0002418)	2.91729143
22	Molar tooth sign on MRI (HP:0002419)	2.91729143
23	Medial flaring of the eyebrow (HP:0010747)	2.89974353
24	Abnormal respiratory motile cilium physiology (HP:0012261)	2.85262794
25	Pancreatic cysts (HP:0001737)	2.84977099
26	Abnormal ciliary motility (HP:0012262)	2.81641190
27	Abnormal number of erythroid precursors (HP:0012131)	2.78027318
28	Abnormality of B cell number (HP:0010975)	2.76395986
29	B lymphocytopenia (HP:0010976)	2.73528883
30	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.72992771
31	Optic disc pallor (HP:0000543)	2.59850758
32	Absent thumb (HP:0009777)	2.59693545
33	Stomatitis (HP:0010280)	2.57215942
34	Hypoplasia of the pons (HP:0012110)	2.55059058
35	Renal Fanconi syndrome (HP:0001994)	2.54645405
36	Pancreatic fibrosis (HP:0100732)	2.54175449
37	Exertional dyspnea (HP:0002875)	2.52379213
38	Congenital stationary night blindness (HP:0007642)	2.52127791
39	Abnormality of the pons (HP:0007361)	2.50809650
40	Cerebral edema (HP:0002181)	2.46701748
41	Increased IgM level (HP:0003496)	2.43147937
42	T lymphocytopenia (HP:0005403)	2.42180368
43	Abnormality of T cell number (HP:0011839)	2.36978283
44	Stenosis of the external auditory canal (HP:0000402)	2.35544205
45	Abnormal rod and cone electroretinograms (HP:0008323)	2.35073163
46	Abnormal hemoglobin (HP:0011902)	2.33865969
47	Abnormal respiratory epithelium morphology (HP:0012253)	2.33045980
48	Abnormal respiratory motile cilium morphology (HP:0005938)	2.33045980
49	Abnormal hair whorl (HP:0010721)	2.31177630
50	Septo-optic dysplasia (HP:0100842)	2.30229042
51	Rib fusion (HP:0000902)	2.27470099
52	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.21991708
53	Increased intramyocellular lipid droplets (HP:0012240)	2.20447006
54	Congenital, generalized hypertrichosis (HP:0004540)	2.13360730
55	Colon cancer (HP:0003003)	2.12992486
56	Abnormality of the prostate (HP:0008775)	2.12930662
57	Hepatocellular necrosis (HP:0001404)	2.11617644
58	Congenital primary aphakia (HP:0007707)	2.11327596
59	Severe combined immunodeficiency (HP:0004430)	2.10913015
60	Hypoproteinemia (HP:0003075)	2.10902764
61	Gait imbalance (HP:0002141)	2.10245799
62	Gastrointestinal infarctions (HP:0005244)	2.08254103
63	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.08075395
64	Attenuation of retinal blood vessels (HP:0007843)	2.06278422
65	Lissencephaly (HP:0001339)	2.04825974
66	Nephrogenic diabetes insipidus (HP:0009806)	2.04453615
67	Thyroiditis (HP:0100646)	2.03743736
68	Abolished electroretinogram (ERG) (HP:0000550)	2.02764838
69	Nephronophthisis (HP:0000090)	2.00824042
70	Sclerocornea (HP:0000647)	1.98980074
71	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.98831497
72	Abnormality of macular pigmentation (HP:0008002)	1.97316458
73	Calf muscle hypertrophy (HP:0008981)	1.96253209
74	Hypoplasia of the radius (HP:0002984)	1.92917367
75	Abnormality of the labia minora (HP:0012880)	1.91267940
76	Reduced antithrombin III activity (HP:0001976)	1.90365190
77	Increased muscle lipid content (HP:0009058)	1.89487506
78	Chronic bronchitis (HP:0004469)	1.89390812
79	Increased serum lactate (HP:0002151)	1.84588178
80	Large for gestational age (HP:0001520)	1.82728028
81	Abnormality of renal resorption (HP:0011038)	1.82637747
82	Abnormality of T cells (HP:0002843)	1.80953595
83	Rhinitis (HP:0012384)	1.80574504
84	Hepatic necrosis (HP:0002605)	1.77076021
85	Lethargy (HP:0001254)	1.76374224
86	Supernumerary spleens (HP:0009799)	1.74422775
87	Abnormality of the renal cortex (HP:0011035)	1.73504961
88	Type I transferrin isoform profile (HP:0003642)	1.72981165
89	Oligodactyly (hands) (HP:0001180)	1.72724044
90	Anencephaly (HP:0002323)	1.72716717
91	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.72550524
92	Growth hormone deficiency (HP:0000824)	1.71401669
93	Muscle hypertrophy of the lower extremities (HP:0008968)	1.70004463
94	Hyperphosphaturia (HP:0003109)	1.67426323
95	Methylmalonic acidemia (HP:0002912)	1.66903516
96	Left ventricular hypertrophy (HP:0001712)	1.66733599
97	Polydipsia (HP:0001959)	1.66580197
98	Abnormal drinking behavior (HP:0030082)	1.66580197
99	Lactic acidosis (HP:0003128)	1.66441407
100	Partial duplication of thumb phalanx (HP:0009944)	1.66159839

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	4.31530092
2	TXK	3.93077237
3	ZAK	3.81738178
4	VRK1	3.52194926
5	VRK2	3.19830576
6	TLK1	3.10977019
7	BCKDK	2.96990329
8	KDR	2.39864118
9	NUAK1	2.21521331
10	ADRBK2	2.16312706
11	TAF1	2.12508128
12	TESK2	1.96071955
13	ITK	1.87140263
14	GRK1	1.77862747
15	WEE1	1.60600516
16	MAP3K12	1.56889797
17	BMPR1B	1.47611766
18	TEC	1.43637231
19	FRK	1.41283183
20	MUSK	1.40092713
21	PNCK	1.38252565
22	STK16	1.33392450
23	WNK3	1.32740921
24	GRK6	1.31858688
25	TNIK	1.23049542
26	DYRK2	1.21194189
27	WNK4	1.19962621
28	TIE1	1.13831890
29	PIK3CA	1.12689821
30	PLK3	1.09714319
31	PRKCQ	1.05214726
32	MAP4K1	1.02562624
33	DAPK2	1.00293697
34	IKBKB	0.99031015
35	MAP4K2	0.96820019
36	MKNK2	0.95705804
37	GRK5	0.94664222
38	BTK	0.88947881
39	CDK19	0.85966445
40	TNK2	0.84929660
41	GRK7	0.81036826
42	PASK	0.79446306
43	MAP2K6	0.78956145
44	CSNK1G2	0.78885125
45	MAP2K2	0.78349534
46	TAOK3	0.76771020
47	CSNK1G3	0.75578749
48	DAPK3	0.75284336
49	PKN1	0.74847618
50	ADRBK1	0.73762931
51	SYK	0.72527366
52	NTRK3	0.72213971
53	NEK2	0.68826209
54	RPS6KA5	0.67849474
55	PRKCG	0.67777465
56	INSRR	0.66874964
57	CSNK1G1	0.65831590
58	TYRO3	0.65396457
59	NTRK2	0.65003725
60	LCK	0.64702139
61	PDK2	0.63936193
62	MAPKAPK5	0.62344389
63	LIMK1	0.62172412
64	OBSCN	0.57303236
65	LYN	0.56222963
66	AURKB	0.54768666
67	CHEK2	0.54538204
68	PINK1	0.54348370
69	MST4	0.54124873
70	PLK4	0.53774495
71	MAPK13	0.53718533
72	BUB1	0.50054344
73	MAP2K7	0.49918211
74	MKNK1	0.49766414
75	CSNK2A2	0.48534539
76	PLK1	0.47668826
77	PRKACA	0.46533214
78	IKBKE	0.46231595
79	CASK	0.45484971
80	MAP3K4	0.45319405
81	MAP3K11	0.44636549
82	CSNK2A1	0.44270072
83	AURKA	0.43482497
84	STK11	0.43058334
85	BMPR2	0.42872052
86	MAP3K2	0.42483759
87	CSNK1A1L	0.42157492
88	EPHB2	0.40423426
89	PIM1	0.38981638
90	ROCK1	0.38167613
91	PRKCA	0.38130620
92	CAMK1	0.37878784
93	RPS6KA4	0.37241086
94	DAPK1	0.36340990
95	FES	0.34176739
96	DYRK1A	0.33761713
97	CSK	0.33690258
98	STK39	0.31697059
99	OXSR1	0.31249087
100	RPS6KA6	0.30421504

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.00218023
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.07793361
3	Proteasome_Homo sapiens_hsa03050	3.67597541
4	Parkinsons disease_Homo sapiens_hsa05012	3.41352972
5	Primary immunodeficiency_Homo sapiens_hsa05340	2.98889571
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.72112374
7	RNA polymerase_Homo sapiens_hsa03020	2.69252129
8	Huntingtons disease_Homo sapiens_hsa05016	2.32687511
9	Alzheimers disease_Homo sapiens_hsa05010	2.31098423
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.22091273
11	Cardiac muscle contraction_Homo sapiens_hsa04260	2.21125270
12	Protein export_Homo sapiens_hsa03060	2.10713858
13	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.97917348
14	Homologous recombination_Homo sapiens_hsa03440	1.92297215
15	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.83591254
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.74098644
17	Graft-versus-host disease_Homo sapiens_hsa05332	1.70296984
18	Phototransduction_Homo sapiens_hsa04744	1.67142213
19	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.66321265
20	Allograft rejection_Homo sapiens_hsa05330	1.58418072
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.57913882
22	Asthma_Homo sapiens_hsa05310	1.51216601
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.50778516
24	RNA degradation_Homo sapiens_hsa03018	1.49714157
25	Basal transcription factors_Homo sapiens_hsa03022	1.41453770
26	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.39408406
27	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.25123149
28	Type I diabetes mellitus_Homo sapiens_hsa04940	1.19294133
29	Caffeine metabolism_Homo sapiens_hsa00232	1.16698554
30	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.14256245
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.13805108
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.13458036
33	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.11416867
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.07079528
35	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.04023736
36	Antigen processing and presentation_Homo sapiens_hsa04612	1.03839542
37	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.00941107
38	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.00516681
39	Rheumatoid arthritis_Homo sapiens_hsa05323	1.00327176
40	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.99853912
41	Peroxisome_Homo sapiens_hsa04146	0.94357181
42	Butanoate metabolism_Homo sapiens_hsa00650	0.90305590
43	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.89671303
44	Olfactory transduction_Homo sapiens_hsa04740	0.89447711
45	Nucleotide excision repair_Homo sapiens_hsa03420	0.89012073
46	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.88956652
47	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.85174485
48	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.84667209
49	Nicotine addiction_Homo sapiens_hsa05033	0.81658491
50	Selenocompound metabolism_Homo sapiens_hsa00450	0.81244154
51	Basal cell carcinoma_Homo sapiens_hsa05217	0.76310569
52	Propanoate metabolism_Homo sapiens_hsa00640	0.73467806
53	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.72879897
54	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.72634469
55	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.72627869
56	One carbon pool by folate_Homo sapiens_hsa00670	0.72303268
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71360934
58	Purine metabolism_Homo sapiens_hsa00230	0.69849859
59	Sulfur relay system_Homo sapiens_hsa04122	0.68637175
60	Taste transduction_Homo sapiens_hsa04742	0.63968323
61	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.63501028
62	Base excision repair_Homo sapiens_hsa03410	0.60995122
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.60886630
64	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.60740542
65	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.59747371
66	Retinol metabolism_Homo sapiens_hsa00830	0.57110670
67	Mismatch repair_Homo sapiens_hsa03430	0.55597755
68	Steroid biosynthesis_Homo sapiens_hsa00100	0.55294504
69	Metabolic pathways_Homo sapiens_hsa01100	0.54616843
70	Morphine addiction_Homo sapiens_hsa05032	0.54286668
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.52186536
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.50169032
73	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.49992097
74	Regulation of autophagy_Homo sapiens_hsa04140	0.47909878
75	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.47364741
76	DNA replication_Homo sapiens_hsa03030	0.45180028
77	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.44669351
78	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.44328434
79	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.43940267
80	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.42973047
81	Malaria_Homo sapiens_hsa05144	0.41735456
82	Measles_Homo sapiens_hsa05162	0.40592325
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40463592
84	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.40410609
85	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.39677741
86	Salmonella infection_Homo sapiens_hsa05132	0.35754821
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.34631287
88	Ether lipid metabolism_Homo sapiens_hsa00565	0.34024887
89	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.33597994
90	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.31325553
91	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.29424435
92	Spliceosome_Homo sapiens_hsa03040	0.26309791
93	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.25562901
94	Folate biosynthesis_Homo sapiens_hsa00790	0.24878582
95	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.24492907
96	RNA transport_Homo sapiens_hsa03013	0.23136507
97	Serotonergic synapse_Homo sapiens_hsa04726	0.21271607
98	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.20648253
99	GABAergic synapse_Homo sapiens_hsa04727	0.20260331
100	Mineral absorption_Homo sapiens_hsa04978	0.16842349

RPL26P35

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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