RPL27A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)9.96202230
2ribosomal small subunit assembly (GO:0000028)9.28126242
3* translational elongation (GO:0006414)9.07994996
4* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)9.01007436
5* protein targeting to ER (GO:0045047)8.86052469
6* cotranslational protein targeting to membrane (GO:0006613)8.85822513
7* establishment of protein localization to endoplasmic reticulum (GO:0072599)8.48329693
8* cellular protein complex disassembly (GO:0043624)8.39490696
9* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)8.33843724
10* viral life cycle (GO:0019058)8.32058528
11* protein localization to endoplasmic reticulum (GO:0070972)8.24992376
12maturation of SSU-rRNA (GO:0030490)8.02208575
13* translational initiation (GO:0006413)7.85519347
14ribosomal large subunit biogenesis (GO:0042273)7.70913334
15* protein complex disassembly (GO:0043241)7.32054478
16* macromolecular complex disassembly (GO:0032984)6.85044651
17* protein targeting to membrane (GO:0006612)5.90910162
18* nuclear-transcribed mRNA catabolic process (GO:0000956)5.80441561
19* mRNA catabolic process (GO:0006402)5.51059305
20* translation (GO:0006412)5.42330025
21ribonucleoprotein complex biogenesis (GO:0022613)5.34490118
22* RNA catabolic process (GO:0006401)5.13619395
23rRNA processing (GO:0006364)4.18586286
24ncRNA 3-end processing (GO:0043628)4.12789411
25rRNA metabolic process (GO:0016072)4.03474224
26* establishment of protein localization to membrane (GO:0090150)3.98636442
27formation of translation preinitiation complex (GO:0001731)3.95388847
28cellular component biogenesis (GO:0044085)3.92501869
29chaperone-mediated protein transport (GO:0072321)3.87284157
30respiratory electron transport chain (GO:0022904)3.68592424
31* protein targeting (GO:0006605)3.65831088
32* establishment of protein localization to organelle (GO:0072594)3.65568832
33DNA deamination (GO:0045006)3.60649317
34electron transport chain (GO:0022900)3.59658607
35DNA strand elongation involved in DNA replication (GO:0006271)3.42428844
36mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.40138355
37spliceosomal snRNP assembly (GO:0000387)3.39579255
38pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.34873115
39telomere maintenance via semi-conservative replication (GO:0032201)3.28553179
40DNA unwinding involved in DNA replication (GO:0006268)3.26815388
41spliceosomal complex assembly (GO:0000245)3.26018703
42regulation of translational fidelity (GO:0006450)3.21908942
43DNA strand elongation (GO:0022616)3.21435509
44regulation of mitochondrial translation (GO:0070129)3.13912642
45folic acid-containing compound biosynthetic process (GO:0009396)3.13659908
46deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.09011586
47DNA replication initiation (GO:0006270)3.03542433
48negative regulation of RNA splicing (GO:0033119)3.03512436
49DNA replication-dependent nucleosome assembly (GO:0006335)3.02250368
50DNA replication-dependent nucleosome organization (GO:0034723)3.02250368
51mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.01722713
52mitochondrial respiratory chain complex I assembly (GO:0032981)3.01722713
53NADH dehydrogenase complex assembly (GO:0010257)3.01722713
54* protein localization to membrane (GO:0072657)3.01603387
55* cellular component disassembly (GO:0022411)2.97336780
56mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.94179704
57ATP biosynthetic process (GO:0006754)2.93931016
58protein complex biogenesis (GO:0070271)2.92183534
59mitochondrial respiratory chain complex assembly (GO:0033108)2.89682402
60ATP synthesis coupled proton transport (GO:0015986)2.86629989
61energy coupled proton transport, down electrochemical gradient (GO:0015985)2.86629989
62pyrimidine nucleotide catabolic process (GO:0006244)2.85009287
63establishment of integrated proviral latency (GO:0075713)2.84222728
64DNA replication checkpoint (GO:0000076)2.81877325
65transcription elongation from RNA polymerase III promoter (GO:0006385)2.80541290
66termination of RNA polymerase III transcription (GO:0006386)2.80541290
67ncRNA processing (GO:0034470)2.78933461
68telomere maintenance via recombination (GO:0000722)2.77817479
69UTP biosynthetic process (GO:0006228)2.77327071
70pseudouridine synthesis (GO:0001522)2.74741487
71oxidative phosphorylation (GO:0006119)2.74629356
72purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.73708699
73* gene expression (GO:0010467)2.73413862
74ribosome biogenesis (GO:0042254)2.73231355
75* protein localization to organelle (GO:0033365)2.71101843
76purine nucleoside triphosphate biosynthetic process (GO:0009145)2.70102637
77inner mitochondrial membrane organization (GO:0007007)2.69740212
78protein localization to kinetochore (GO:0034501)2.69052138
79chromatin remodeling at centromere (GO:0031055)2.68679380
80mitotic recombination (GO:0006312)2.68516182
81telomere maintenance via telomere lengthening (GO:0010833)2.67799428
82nucleotide-excision repair, DNA gap filling (GO:0006297)2.64499082
83GTP biosynthetic process (GO:0006183)2.60835417
84ribonucleoside triphosphate biosynthetic process (GO:0009201)2.59665215
85pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.59577955
86ribonucleoprotein complex assembly (GO:0022618)2.56709730
87CENP-A containing nucleosome assembly (GO:0034080)2.56116379
88proteasome assembly (GO:0043248)2.55882194
89DNA damage response, detection of DNA damage (GO:0042769)2.55534662
90ncRNA metabolic process (GO:0034660)2.53610721
91protein targeting to mitochondrion (GO:0006626)2.52155163
92regulation of protein heterodimerization activity (GO:0043497)2.51520173
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.50439162
94RNA splicing, via transesterification reactions (GO:0000375)2.49735717
95termination of RNA polymerase II transcription (GO:0006369)2.49613970
96mRNA splicing, via spliceosome (GO:0000398)2.48899146
97RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.48899146
98establishment of protein localization to mitochondrion (GO:0072655)2.48295415
99deoxyribonucleotide catabolic process (GO:0009264)2.48246539
100kinetochore organization (GO:0051383)2.46357722
101histone mRNA metabolic process (GO:0008334)2.45877882
102pteridine-containing compound biosynthetic process (GO:0042559)2.45098349
103deoxyribose phosphate catabolic process (GO:0046386)2.44574394
104ribonucleoprotein complex subunit organization (GO:0071826)2.42904898
105transcription-coupled nucleotide-excision repair (GO:0006283)2.42070201
106protein localization to chromosome, centromeric region (GO:0071459)2.41109252
107regulation of posttranscriptional gene silencing (GO:0060147)2.39573574
108regulation of gene silencing by miRNA (GO:0060964)2.39573574
109regulation of gene silencing by RNA (GO:0060966)2.39573574
110rRNA modification (GO:0000154)2.39463241
111viral protein processing (GO:0019082)2.38969636
112pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.38905744
113myeloid cell homeostasis (GO:0002262)2.38615702
114UTP metabolic process (GO:0046051)2.37778462
115pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.37224573
116nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.36431398
117GDP-mannose metabolic process (GO:0019673)2.36317989
118establishment of viral latency (GO:0019043)2.35456631
119establishment of protein localization to mitochondrial membrane (GO:0090151)2.34416430
120aerobic respiration (GO:0009060)2.32836255
121pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.31823239
122DNA-templated transcription, termination (GO:0006353)2.31424879
123DNA replication-independent nucleosome organization (GO:0034724)2.30552246
124DNA replication-independent nucleosome assembly (GO:0006336)2.30552246
125mitotic nuclear envelope disassembly (GO:0007077)2.29995332
126purine nucleoside monophosphate biosynthetic process (GO:0009127)2.29951662
127purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.29951662
128sequestering of actin monomers (GO:0042989)2.29522366
129negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.28892281
130negative regulation of translational initiation (GO:0045947)2.27575260
131negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.26130099
132CTP metabolic process (GO:0046036)2.24381610
133negative regulation of DNA-templated transcription, elongation (GO:0032785)2.23742594
134deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.22134184
135protein localization to mitochondrion (GO:0070585)2.20025163
136heterochromatin organization (GO:0070828)2.19940359
137nucleoside triphosphate biosynthetic process (GO:0009142)2.19934807
138hydrogen ion transmembrane transport (GO:1902600)2.19083670
139* viral transcription (GO:0019083)11.2452232
140* translational termination (GO:0006415)10.8060188

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.50493787
2* MYC_18555785_ChIP-Seq_MESCs_Mouse5.01530859
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.36713736
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.82615584
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.81458441
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.23585153
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.12925813
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.11069767
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.01522811
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.99525117
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.94900512
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90506394
13* XRN2_22483619_ChIP-Seq_HELA_Human2.85647831
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.85589740
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78861287
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73695528
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.68876869
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.68602208
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.59865350
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39977654
21* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39448321
22* TTF2_22483619_ChIP-Seq_HELA_Human2.35347665
23VDR_23849224_ChIP-Seq_CD4+_Human2.21686610
24DCP1A_22483619_ChIP-Seq_HELA_Human2.19829428
25* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08015250
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96542215
27FOXP3_21729870_ChIP-Seq_TREG_Human1.95308691
28* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.92551975
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.87305936
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81260224
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80777560
32* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79505468
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77149347
34* ELK1_19687146_ChIP-ChIP_HELA_Human1.72898264
35* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.69224132
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66890501
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64404140
38MYC_22102868_ChIP-Seq_BL_Human1.61119198
39ZNF263_19887448_ChIP-Seq_K562_Human1.60935760
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59620691
41* GABP_19822575_ChIP-Seq_HepG2_Human1.52912547
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.49022008
43VDR_21846776_ChIP-Seq_THP-1_Human1.47542041
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47000088
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46621248
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42280149
47SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.41565588
48CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40742020
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.38709444
50MYC_18940864_ChIP-ChIP_HL60_Human1.38021414
51* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37846311
52KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.37621024
53KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.37621024
54KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.37621024
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36883307
56* ELK1_22589737_ChIP-Seq_MCF10A_Human1.35256902
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34465158
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34246164
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33942998
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33193805
61* LXR_22292898_ChIP-Seq_THP-1_Human1.32833443
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32241499
63CIITA_25753668_ChIP-Seq_RAJI_Human1.31763773
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.31590932
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31370315
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30703035
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30698561
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29063796
69P68_20966046_ChIP-Seq_HELA_Human1.28141586
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25654043
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.24628638
72* FOXP1_21924763_ChIP-Seq_HESCs_Human1.24376103
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23200523
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23021241
75* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22847298
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22270051
77CTCF_18555785_ChIP-Seq_MESCs_Mouse1.22269959
78FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22088464
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21581595
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21036918
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20516944
82* KDM5A_27292631_Chip-Seq_BREAST_Human1.19845017
83AR_21909140_ChIP-Seq_LNCAP_Human1.19428351
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18674483
85TCF3_18692474_ChIP-Seq_MEFs_Mouse1.18221290
86EGR1_19374776_ChIP-ChIP_THP-1_Human1.18136828
87TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16023960
88ELF1_20517297_ChIP-Seq_JURKAT_Human1.15951278
89SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13503028
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11839665
91PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11134764
92CTCF_26484167_Chip-Seq_Bcells_Mouse1.10721951
93STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09468000
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09326997
95* SA1_27219007_Chip-Seq_ERYTHROID_Human1.09321575
96KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07973645
97BCL6_27268052_Chip-Seq_Bcells_Human1.07151509
98OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05875452
99SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99596541
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99527055
101VDR_24763502_ChIP-Seq_THP-1_Human0.98700156
102TP63_19390658_ChIP-ChIP_HaCaT_Human0.98416312
103CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97072060
104PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96158125
105* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94732260
106YY1_22570637_ChIP-Seq_MALME-3M_Human0.94533714
107CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94196033
108BCOR_27268052_Chip-Seq_Bcells_Human0.93897178
109* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92950398
110MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92748309
111E2F1_20622854_ChIP-Seq_HELA_Human0.91660830
112KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90359201
113EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89893415
114* SPI1_23547873_ChIP-Seq_NB4_Human0.89847157
115PHF8_20622854_ChIP-Seq_HELA_Human0.89809685
116SA1_27219007_Chip-Seq_Bcells_Human0.87799716
117* MAF_26560356_Chip-Seq_TH2_Human0.87733399
118UTX_26944678_Chip-Seq_JUKART_Human0.87583951
119CTCF_21964334_Chip-Seq_Bcells_Human0.87394702
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87276385
121PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86584059
122SRF_21415370_ChIP-Seq_HL-1_Mouse0.84805091
123* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82683614
124GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82120744
125ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.81648365
126TFEB_21752829_ChIP-Seq_HELA_Human0.81223572
127MAF_26560356_Chip-Seq_TH1_Human0.80563692

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation7.03849048
2MP0003693_abnormal_embryo_hatching3.72628411
3MP0004957_abnormal_blastocyst_morpholog3.65324584
4MP0006292_abnormal_olfactory_placode3.31681464
5MP0010094_abnormal_chromosome_stability2.84111700
6MP0003111_abnormal_nucleus_morphology2.77622442
7MP0003077_abnormal_cell_cycle2.68110517
8MP0008932_abnormal_embryonic_tissue2.36553701
9MP0003136_yellow_coat_color2.13022528
10MP0003941_abnormal_skin_development2.08705370
11MP0008007_abnormal_cellular_replicative1.99236029
12MP0004381_abnormal_hair_follicle1.86129354
13MP0008057_abnormal_DNA_replication1.85438049
14MP0010030_abnormal_orbit_morphology1.84821838
15MP0000490_abnormal_crypts_of1.82224608
16MP0008058_abnormal_DNA_repair1.82098164
17MP0000566_synostosis1.67203486
18MP0009333_abnormal_splenocyte_physiolog1.62184925
19MP0003786_premature_aging1.61996523
20MP0000350_abnormal_cell_proliferation1.61646872
21MP0002796_impaired_skin_barrier1.58305416
22MP0003763_abnormal_thymus_physiology1.57232191
23MP0002396_abnormal_hematopoietic_system1.57179311
24MP0000372_irregular_coat_pigmentation1.53178552
25MP0003123_paternal_imprinting1.52305183
26MP0005501_abnormal_skin_physiology1.50324622
27MP0010352_gastrointestinal_tract_polyps1.48467244
28MP0001730_embryonic_growth_arrest1.47095457
29MP0005671_abnormal_response_to1.43623259
30MP0002132_abnormal_respiratory_system1.43350842
31MP0006035_abnormal_mitochondrial_morpho1.42155262
32MP0008995_early_reproductive_senescence1.40743464
33MP0003806_abnormal_nucleotide_metabolis1.36873510
34MP0003186_abnormal_redox_activity1.36438296
35MP0004142_abnormal_muscle_tone1.33768075
36MP0005174_abnormal_tail_pigmentation1.32414646
37MP0002653_abnormal_ependyma_morphology1.30837745
38MP0009053_abnormal_anal_canal1.25543552
39MP0000703_abnormal_thymus_morphology1.25375715
40MP0001697_abnormal_embryo_size1.22200312
41MP0003303_peritoneal_inflammation1.20967387
42MP0003315_abnormal_perineum_morphology1.20727609
43MP0001986_abnormal_taste_sensitivity1.20290403
44MP0002085_abnormal_embryonic_tissue1.18289320
45MP0002019_abnormal_tumor_incidence1.16729790
46MP0008789_abnormal_olfactory_epithelium1.14239562
47MP0002080_prenatal_lethality1.12909788
48MP0002277_abnormal_respiratory_mucosa1.09812847
49MP0003567_abnormal_fetal_cardiomyocyte1.09395094
50MP0003453_abnormal_keratinocyte_physiol1.07987594
51MP0004808_abnormal_hematopoietic_stem1.07896798
52MP0000858_altered_metastatic_potential1.07873945
53MP0000313_abnormal_cell_death1.07606755
54MP0004185_abnormal_adipocyte_glucose1.06044628
55MP0000049_abnormal_middle_ear1.04895860
56MP0001672_abnormal_embryogenesis/_devel1.03394047
57MP0005380_embryogenesis_phenotype1.03394047
58MP0002084_abnormal_developmental_patter1.03222359
59MP0000537_abnormal_urethra_morphology1.02928173
60MP0003878_abnormal_ear_physiology1.02040807
61MP0005377_hearing/vestibular/ear_phenot1.02040807
62MP0002722_abnormal_immune_system1.01626542
63MP0002398_abnormal_bone_marrow1.00047799
64MP0001800_abnormal_humoral_immune0.98817713
65MP0002095_abnormal_skin_pigmentation0.98232893
66MP0002166_altered_tumor_susceptibility0.97178731
67MP0000762_abnormal_tongue_morphology0.96206154
68MP0003718_maternal_effect0.94604560
69MP0005076_abnormal_cell_differentiation0.91700483
70MP0002086_abnormal_extraembryonic_tissu0.91393782
71MP0001216_abnormal_epidermal_layer0.90806949
72MP0004197_abnormal_fetal_growth/weight/0.90344439
73MP0005171_absent_coat_pigmentation0.89615091
74MP0000685_abnormal_immune_system0.89566813
75MP0002163_abnormal_gland_morphology0.88647458
76MP0009278_abnormal_bone_marrow0.88625671
77MP0002060_abnormal_skin_morphology0.88534265
78MP0002938_white_spotting0.88113302
79MP0002111_abnormal_tail_morphology0.88076488
80MP0005084_abnormal_gallbladder_morpholo0.87283618
81MP0005394_taste/olfaction_phenotype0.87230817
82MP0005499_abnormal_olfactory_system0.87230817
83MP0002098_abnormal_vibrissa_morphology0.87055379
84MP0001663_abnormal_digestive_system0.86472656
85MP0002088_abnormal_embryonic_growth/wei0.86454981
86MP0003011_delayed_dark_adaptation0.85859646
87MP0002697_abnormal_eye_size0.85793991
88MP0000613_abnormal_salivary_gland0.85225859
89MP0003938_abnormal_ear_development0.85145883
90MP0000689_abnormal_spleen_morphology0.84688456
91MP0003984_embryonic_growth_retardation0.84648875
92MP0000467_abnormal_esophagus_morphology0.83785144
93MP0003119_abnormal_digestive_system0.83577843
94MP0006036_abnormal_mitochondrial_physio0.83363016
95MP0002405_respiratory_system_inflammati0.83214099
96MP0000678_abnormal_parathyroid_gland0.83086622
97MP0002006_tumorigenesis0.82531935
98MP0002429_abnormal_blood_cell0.81383132
99MP0005023_abnormal_wound_healing0.81341652
100MP0004133_heterotaxia0.80826295
101MP0001293_anophthalmia0.80519303
102MP0002210_abnormal_sex_determination0.80243545
103MP0002282_abnormal_trachea_morphology0.80024765
104MP0002249_abnormal_larynx_morphology0.79848530
105MP0005408_hypopigmentation0.78152163
106MP0001286_abnormal_eye_development0.77393576
107MP0010155_abnormal_intestine_physiology0.76526826
108MP0002452_abnormal_antigen_presenting0.76164013
109MP0002420_abnormal_adaptive_immunity0.75900309
110MP0000716_abnormal_immune_system0.75796252
111MP0002102_abnormal_ear_morphology0.75447629
112MP0010771_integument_phenotype0.75359116
113MP0000358_abnormal_cell_content/0.74945210
114MP0002009_preneoplasia0.74326538
115MP0001873_stomach_inflammation0.73848223
116MP0001819_abnormal_immune_cell0.73782582
117MP0000477_abnormal_intestine_morphology0.72687409
118MP0000750_abnormal_muscle_regeneration0.72010096
119MP0001346_abnormal_lacrimal_gland0.71238573
120MP0010307_abnormal_tumor_latency0.70709145
121MP0000377_abnormal_hair_follicle0.70552993
122MP0001348_abnormal_lacrimal_gland0.69656290
123MP0001835_abnormal_antigen_presentation0.69368878
124MP0002177_abnormal_outer_ear0.68772100
125MP0003937_abnormal_limbs/digits/tail_de0.68095750
126MP0005000_abnormal_immune_tolerance0.67275170
127MP0001881_abnormal_mammary_gland0.67153870
128MP0002723_abnormal_immune_serum0.66652627
129MP0003436_decreased_susceptibility_to0.66286108
130MP0005075_abnormal_melanosome_morpholog0.66088798
131MP0000631_abnormal_neuroendocrine_gland0.65287704
132MP0005083_abnormal_biliary_tract0.65250381
133MP0005381_digestive/alimentary_phenotyp0.65055709
134MP0003283_abnormal_digestive_organ0.63135030
135MP0005025_abnormal_response_to0.62283934
136MP0005387_immune_system_phenotype0.62272575
137MP0001790_abnormal_immune_system0.62272575
138MP0009250_abnormal_appendicular_skeleto0.61520722
139MP0002160_abnormal_reproductive_system0.61501004

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)9.02370876
2Abnormality of cells of the erythroid lineage (HP:0012130)8.85396636
3Abnormal number of erythroid precursors (HP:0012131)7.81744867
4Macrocytic anemia (HP:0001972)7.11302239
5Pallor (HP:0000980)6.47458289
6Abnormal hemoglobin (HP:0011902)5.84526491
7Aplasia/Hypoplasia of the sacrum (HP:0008517)4.34335065
8Colon cancer (HP:0003003)3.54127117
9Trismus (HP:0000211)3.20571264
10Absent thumb (HP:0009777)3.11757961
11Abnormality of reticulocytes (HP:0004312)3.03361898
12Depressed nasal ridge (HP:0000457)2.98578746
13Increased muscle lipid content (HP:0009058)2.96027374
14Increased hepatocellular lipid droplets (HP:0006565)2.91372925
15Thrombocytosis (HP:0001894)2.88320166
16Triphalangeal thumb (HP:0001199)2.86735841
17Congenital, generalized hypertrichosis (HP:0004540)2.86024546
18Concave nail (HP:0001598)2.80632801
19Rib fusion (HP:0000902)2.78054467
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.75952963
21Hypoplasia of the pons (HP:0012110)2.73251046
2211 pairs of ribs (HP:0000878)2.71444662
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.60944564
24Decreased activity of mitochondrial respiratory chain (HP:0008972)2.60944564
25Thick lower lip vermilion (HP:0000179)2.56037748
26Cerebral edema (HP:0002181)2.55285454
27Stenosis of the external auditory canal (HP:0000402)2.55282879
28Breast hypoplasia (HP:0003187)2.54850128
29Woolly hair (HP:0002224)2.54846715
30Septo-optic dysplasia (HP:0100842)2.54185075
31Multiple enchondromatosis (HP:0005701)2.54142730
32Abnormality of the pons (HP:0007361)2.53346429
33Asplenia (HP:0001746)2.50582027
34Migraine (HP:0002076)2.50115622
35Oral leukoplakia (HP:0002745)2.47768477
36Exertional dyspnea (HP:0002875)2.45544668
37Mitochondrial inheritance (HP:0001427)2.42493197
38Lipid accumulation in hepatocytes (HP:0006561)2.38627164
39Sparse lateral eyebrow (HP:0005338)2.38540659
40Hypoplasia of the radius (HP:0002984)2.29889423
41Aplasia/Hypoplasia of the spleen (HP:0010451)2.27641269
42Selective tooth agenesis (HP:0001592)2.23454489
43Abnormality of the parietal bone (HP:0002696)2.20968542
44Aplastic anemia (HP:0001915)2.20766510
45Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20158565
46Exercise intolerance (HP:0003546)2.19104554
47Acute necrotizing encephalopathy (HP:0006965)2.17319565
48Rough bone trabeculation (HP:0100670)2.17173990
49Lactic acidosis (HP:0003128)2.16020863
50Hepatocellular necrosis (HP:0001404)2.14042898
51Partial duplication of the phalanx of hand (HP:0009999)2.11507997
52Horseshoe kidney (HP:0000085)2.11063049
53Agammaglobulinemia (HP:0004432)2.11051057
54Panhypogammaglobulinemia (HP:0003139)2.09188036
55Atresia of the external auditory canal (HP:0000413)2.08623228
56Abnormality of the 4th metacarpal (HP:0010012)2.06504431
57Glossoptosis (HP:0000162)2.06357644
58Missing ribs (HP:0000921)2.05522433
59Pancytopenia (HP:0001876)2.04370477
60Hypertensive crisis (HP:0100735)2.03843922
61Basal cell carcinoma (HP:0002671)2.02435095
62Cleft eyelid (HP:0000625)2.00534113
63Neoplasm of the pancreas (HP:0002894)1.99991979
64Increased CSF lactate (HP:0002490)1.97786355
65Abnormality of DNA repair (HP:0003254)1.97466995
66Fragile nails (HP:0001808)1.97283799
67Absent radius (HP:0003974)1.95832387
68Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.95620681
69Short 4th metacarpal (HP:0010044)1.95620681
70Rhabdomyosarcoma (HP:0002859)1.93066585
71Respiratory difficulties (HP:0002880)1.91754480
72Abnormality of the preputium (HP:0100587)1.90548657
73Partial duplication of thumb phalanx (HP:0009944)1.90003483
74Renal Fanconi syndrome (HP:0001994)1.86865130
75Abnormal number of incisors (HP:0011064)1.84690466
76Secondary amenorrhea (HP:0000869)1.83508218
77Cerebellar dysplasia (HP:0007033)1.82873422
78Brushfield spots (HP:0001088)1.82206450
79Abnormal mitochondria in muscle tissue (HP:0008316)1.81976856
80Absent forearm bone (HP:0003953)1.81433175
81Aplasia involving forearm bones (HP:0009822)1.81433175
82Patellar aplasia (HP:0006443)1.80331812
83Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.80316897
84Increased intramyocellular lipid droplets (HP:0012240)1.79971149
85Respiratory failure (HP:0002878)1.79394502
86Supernumerary spleens (HP:0009799)1.77763261
87Premature ovarian failure (HP:0008209)1.76967852
88Aplasia/Hypoplasia of the patella (HP:0006498)1.76765155
89Nasolacrimal duct obstruction (HP:0000579)1.76732657
90Ridged nail (HP:0001807)1.75412640
91Premature graying of hair (HP:0002216)1.74869278
92Maternal diabetes (HP:0009800)1.74758765
93Abdominal situs inversus (HP:0003363)1.74640480
94Abnormality of abdominal situs (HP:0011620)1.74640480
95Progressive macrocephaly (HP:0004481)1.74237305
96Optic disc pallor (HP:0000543)1.74162961
97Microvesicular hepatic steatosis (HP:0001414)1.73105882
98Abnormality of secondary sexual hair (HP:0009888)1.70888257
99Abnormality of the axillary hair (HP:0100134)1.70888257
100Down-sloping shoulders (HP:0200021)1.70150502
101Birth length less than 3rd percentile (HP:0003561)1.69479685
102IgM deficiency (HP:0002850)1.67238168
103Muscle fiber atrophy (HP:0100295)1.67170821
104Sparse eyelashes (HP:0000653)1.66995484
105Microretrognathia (HP:0000308)1.65472765
106Meckel diverticulum (HP:0002245)1.64768278
107Forearm undergrowth (HP:0009821)1.64596903
1083-Methylglutaconic aciduria (HP:0003535)1.64554846
109Testicular atrophy (HP:0000029)1.63372057
110Hypoplasia of the ulna (HP:0003022)1.62779299
111Increased serum lactate (HP:0002151)1.61927304
112Aplasia/Hypoplasia of the thymus (HP:0010515)1.60894122
113Broad distal phalanx of finger (HP:0009836)1.58473412
114Colitis (HP:0002583)1.58033362
115Myelodysplasia (HP:0002863)1.57666330
116Absent septum pellucidum (HP:0001331)1.57367954
117Sparse scalp hair (HP:0002209)1.56835333
118Abnormality of the ileum (HP:0001549)1.56456089
119Progressive muscle weakness (HP:0003323)1.56354449
120Tracheoesophageal fistula (HP:0002575)1.55993124
121Seborrheic dermatitis (HP:0001051)1.55982905
122Medulloblastoma (HP:0002885)1.55648274
123Squamous cell carcinoma (HP:0002860)1.54842708
124Duplication of thumb phalanx (HP:0009942)1.54142237
125Hepatic necrosis (HP:0002605)1.53068233
126Short nose (HP:0003196)1.52794188
127Acute encephalopathy (HP:0006846)1.52412759
128Carpal bone hypoplasia (HP:0001498)1.51256645
129Chromsome breakage (HP:0040012)1.51061533
130Abnormal trabecular bone morphology (HP:0100671)1.50912231
131Leukodystrophy (HP:0002415)1.48974023
132Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.48517326
133Poikiloderma (HP:0001029)1.47659726
134Abnormality of small intestinal villus morphology (HP:0011472)1.47585768
135Villous atrophy (HP:0011473)1.47585768
136Type II lissencephaly (HP:0007260)1.46395094
137Neutropenia (HP:0001875)1.46327527
138Short femoral neck (HP:0100864)1.45628894
139Chromosomal breakage induced by crosslinking agents (HP:0003221)1.45332615
140Bowed forearm bones (HP:0003956)1.44587709
141Bowing of the arm (HP:0006488)1.44587709
142Cellular immunodeficiency (HP:0005374)1.44343308

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK16.46946070
2NME25.46402693
3VRK24.26094519
4BUB13.10185345
5WEE12.73856192
6EIF2AK12.72506610
7RPS6KB22.51044107
8SRPK12.18339549
9EEF2K2.13776871
10CDC72.08304328
11TESK21.97716319
12LRRK21.94631536
13SMG11.92733795
14MAP3K101.90419577
15VRK11.88653176
16BCKDK1.83499404
17MAPK151.78639994
18PRPF4B1.73259727
19MST41.71206458
20DYRK31.65350407
21PIM21.62916301
22MAP4K11.59250356
23NEK21.51743496
24STK161.48408674
25CDK71.45681617
26AURKB1.43184113
27CDK191.42875061
28PASK1.36379328
29MKNK11.28687422
30STK101.28016997
31ARAF1.27964756
32RPS6KA41.27640341
33MKNK21.25645385
34EPHA21.22353304
35NME11.20162804
36PLK11.18084992
37BLK1.16433756
38TAOK21.15757591
39TGFBR11.15566492
40TTK1.15544835
41CLK11.14313938
42TYRO31.12378166
43WNK41.11611523
44MAP3K81.08946637
45AURKA1.08780394
46ILK1.08458891
47PIM11.07835769
48ERN11.06185770
49GRK61.06099519
50RPS6KA51.03297934
51DAPK31.02821608
52TRIB31.02759190
53PBK1.00070744
54PKN21.00051152
55MOS0.99267150
56MAP3K110.99049261
57MAPKAPK30.95659013
58EIF2AK30.94595344
59FLT30.90116712
60PLK40.89545780
61CDK40.88061947
62TAOK30.82369703
63CSNK2A20.81456926
64STK40.80388886
65NLK0.80132415
66TSSK60.79913831
67PAK40.78265700
68SCYL20.77567870
69MAP2K20.75823189
70PAK10.72666141
71TXK0.72317317
72RPS6KA60.72063905
73ATR0.71030028
74BRAF0.70729881
75SYK0.69960336
76CHEK20.69732411
77BRSK20.69310738
78TBK10.69045882
79KDR0.67677457
80MARK30.67275635
81CDK90.66094585
82MAP3K90.65137554
83ABL20.64662545
84IRAK40.62834985
85TAF10.62780038
86PDK20.61476171
87PAK20.60950852
88PRKCI0.60690449
89CSNK2A10.60401385
90DYRK1B0.59650030
91CHEK10.59568371
92ZAP700.58755793
93ALK0.57495369
94IKBKB0.57269431
95BTK0.56890880
96CDK120.56724381
97NEK90.55512953
98ITK0.55084717
99CDK80.55012164
100ZAK0.54002144
101MUSK0.53608850
102NEK10.51837792
103TEC0.51412594
104CDK60.50944192
105MAP2K30.49432622
106SIK10.49388493
107ATM0.48338509
108PRKD20.47883477
109TESK10.47417532
110CDK20.47001547
111ICK0.46855441
112KIT0.45852073
113IRAK30.43686865
114FES0.43095387
115IKBKE0.42644795
116LCK0.42465648
117ACVR1B0.42231834
118LIMK10.40859739
119DYRK20.40743715
120BMX0.40535360
121CSK0.39577478
122EIF2AK20.38958934
123HIPK20.38516691
124EPHB20.37700750
125PRKCQ0.37631994
126ADRBK10.36630605
127MAP3K70.34439872
128MAP3K130.33581004
129AKT20.31669454
130RPS6KC10.31224098
131RPS6KL10.31224098
132MELK0.29431380
133CSNK1E0.29060668
134MST1R0.28908381
135UHMK10.28846270
136RPS6KA10.28531543
137LYN0.28185213

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030108.49442398
2DNA replication_Homo sapiens_hsa030303.61816314
3Mismatch repair_Homo sapiens_hsa034303.17071986
4Spliceosome_Homo sapiens_hsa030403.11857536
5RNA polymerase_Homo sapiens_hsa030202.97146682
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.64959894
7Homologous recombination_Homo sapiens_hsa034402.52613659
8Proteasome_Homo sapiens_hsa030502.52517275
9One carbon pool by folate_Homo sapiens_hsa006702.25873798
10Nucleotide excision repair_Homo sapiens_hsa034202.25357005
11RNA transport_Homo sapiens_hsa030132.23359750
12Base excision repair_Homo sapiens_hsa034102.10650768
13Pyrimidine metabolism_Homo sapiens_hsa002402.05142127
14Oxidative phosphorylation_Homo sapiens_hsa001901.99010469
15Parkinsons disease_Homo sapiens_hsa050121.94453608
16Systemic lupus erythematosus_Homo sapiens_hsa053221.90793784
17Fanconi anemia pathway_Homo sapiens_hsa034601.72666112
18Protein export_Homo sapiens_hsa030601.60977281
19Huntingtons disease_Homo sapiens_hsa050161.58402577
20Cell cycle_Homo sapiens_hsa041101.54630525
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47835991
22Sulfur relay system_Homo sapiens_hsa041221.46109848
23Basal transcription factors_Homo sapiens_hsa030221.37612180
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.32806559
25Non-homologous end-joining_Homo sapiens_hsa034501.32568902
26mRNA surveillance pathway_Homo sapiens_hsa030151.28536487
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28316131
28p53 signaling pathway_Homo sapiens_hsa041151.27639387
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27180098
30RNA degradation_Homo sapiens_hsa030181.25613738
31Alzheimers disease_Homo sapiens_hsa050101.24662963
32Primary immunodeficiency_Homo sapiens_hsa053401.02540495
33Autoimmune thyroid disease_Homo sapiens_hsa053200.99952088
34Epstein-Barr virus infection_Homo sapiens_hsa051690.95437034
35Graft-versus-host disease_Homo sapiens_hsa053320.93768253
36Antigen processing and presentation_Homo sapiens_hsa046120.88115170
37Herpes simplex infection_Homo sapiens_hsa051680.85982042
38Purine metabolism_Homo sapiens_hsa002300.84474649
39Alcoholism_Homo sapiens_hsa050340.83815655
40Viral carcinogenesis_Homo sapiens_hsa052030.82829552
41Folate biosynthesis_Homo sapiens_hsa007900.82637281
42Basal cell carcinoma_Homo sapiens_hsa052170.80968781
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75036051
44Thyroid cancer_Homo sapiens_hsa052160.71365493
45Biosynthesis of amino acids_Homo sapiens_hsa012300.69899383
46HTLV-I infection_Homo sapiens_hsa051660.68834529
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68807024
48Bladder cancer_Homo sapiens_hsa052190.66696729
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65166178
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59731184
51Fructose and mannose metabolism_Homo sapiens_hsa000510.58991684
52Small cell lung cancer_Homo sapiens_hsa052220.54927338
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.54664958
54MicroRNAs in cancer_Homo sapiens_hsa052060.53742242
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51579749
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51011409
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50573252
58Hematopoietic cell lineage_Homo sapiens_hsa046400.50522209
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49050182
60Cardiac muscle contraction_Homo sapiens_hsa042600.46604441
61Carbon metabolism_Homo sapiens_hsa012000.45997416
62Apoptosis_Homo sapiens_hsa042100.45488911
63Acute myeloid leukemia_Homo sapiens_hsa052210.45185973
64Vitamin digestion and absorption_Homo sapiens_hsa049770.44040773
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.43973468
66Glutathione metabolism_Homo sapiens_hsa004800.43745953
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.43402179
68Hedgehog signaling pathway_Homo sapiens_hsa043400.42800864
69Notch signaling pathway_Homo sapiens_hsa043300.42793569
70Pentose phosphate pathway_Homo sapiens_hsa000300.41110565
71Measles_Homo sapiens_hsa051620.40234843
72Type I diabetes mellitus_Homo sapiens_hsa049400.39916878
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38880876
74TGF-beta signaling pathway_Homo sapiens_hsa043500.37815881
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36484077
76Hippo signaling pathway_Homo sapiens_hsa043900.36263060
77Pathways in cancer_Homo sapiens_hsa052000.34687877
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.33265327
79Chronic myeloid leukemia_Homo sapiens_hsa052200.32316539
80Pyruvate metabolism_Homo sapiens_hsa006200.32227588
81Hepatitis B_Homo sapiens_hsa051610.31062370
82Galactose metabolism_Homo sapiens_hsa000520.30612138
83Arachidonic acid metabolism_Homo sapiens_hsa005900.30425444
84Fat digestion and absorption_Homo sapiens_hsa049750.30326144
85Legionellosis_Homo sapiens_hsa051340.28760270
86T cell receptor signaling pathway_Homo sapiens_hsa046600.27470588
87Wnt signaling pathway_Homo sapiens_hsa043100.27119677
88B cell receptor signaling pathway_Homo sapiens_hsa046620.26777159
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.26484692
90Leishmaniasis_Homo sapiens_hsa051400.26169788
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.25587190
92Oocyte meiosis_Homo sapiens_hsa041140.25474671
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25153333
94Shigellosis_Homo sapiens_hsa051310.25095493
95Prostate cancer_Homo sapiens_hsa052150.23468404
96Peroxisome_Homo sapiens_hsa041460.23341621
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23206328
98Colorectal cancer_Homo sapiens_hsa052100.22859574
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.21685963
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21077531
101HIF-1 signaling pathway_Homo sapiens_hsa040660.20368137
102Viral myocarditis_Homo sapiens_hsa054160.19891390
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.19639606
104Melanoma_Homo sapiens_hsa052180.18986208
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18716438
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18664484
107Metabolic pathways_Homo sapiens_hsa011000.18219828
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18074140
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18035392
110Asthma_Homo sapiens_hsa053100.17556451
111Other glycan degradation_Homo sapiens_hsa005110.17524589
112Linoleic acid metabolism_Homo sapiens_hsa005910.15633310
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.15513830
114Proteoglycans in cancer_Homo sapiens_hsa052050.15253891
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15140860
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14979689
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.14793377
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14197148
119Allograft rejection_Homo sapiens_hsa053300.12271081
120Tight junction_Homo sapiens_hsa045300.11668530
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.11484469
122Adherens junction_Homo sapiens_hsa045200.11108473
123N-Glycan biosynthesis_Homo sapiens_hsa005100.10209221
124Tyrosine metabolism_Homo sapiens_hsa003500.07727511
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.05067821
126Influenza A_Homo sapiens_hsa051640.04721563
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.03425570
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.02519479

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