RPL27AP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of isotype switching to IgG isotypes (GO:0048302)7.24622411
2activation of MAPKKK activity (GO:0000185)6.74922621
3lens fiber cell development (GO:0070307)6.57008698
4chaperone-mediated protein transport (GO:0072321)6.49583676
5viral transcription (GO:0019083)5.95647611
6leukocyte aggregation (GO:0070486)5.80008596
7translational termination (GO:0006415)5.63517625
8positive regulation of isotype switching (GO:0045830)4.99426704
9translational elongation (GO:0006414)4.67137858
10positive regulation of defense response to virus by host (GO:0002230)4.59390695
11activated T cell proliferation (GO:0050798)4.59331651
12dopamine transport (GO:0015872)4.51547352
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.50213418
14protein targeting to ER (GO:0045047)4.49575648
15cotranslational protein targeting to membrane (GO:0006613)4.44101035
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.41945366
17positive regulation of DNA recombination (GO:0045911)4.34617023
18ribosomal small subunit biogenesis (GO:0042274)4.32885001
19ribosomal small subunit assembly (GO:0000028)4.31746855
20establishment of protein localization to endoplasmic reticulum (GO:0072599)4.25709128
21viral life cycle (GO:0019058)4.24863681
22cellular protein complex disassembly (GO:0043624)4.24157208
23neurofilament cytoskeleton organization (GO:0060052)4.22481242
24protein localization to endoplasmic reticulum (GO:0070972)4.17907257
25positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)4.16772214
26regulation of DNA methylation (GO:0044030)4.04074419
27establishment of protein localization to mitochondrial membrane (GO:0090151)4.03468870
28glyoxylate metabolic process (GO:0046487)3.98442213
29maturation of SSU-rRNA (GO:0030490)3.85295109
30ATP synthesis coupled proton transport (GO:0015986)3.80509386
31energy coupled proton transport, down electrochemical gradient (GO:0015985)3.80509386
32interferon-gamma production (GO:0032609)3.77546872
33glycoprotein catabolic process (GO:0006516)3.77392162
34mast cell activation (GO:0045576)3.70451908
35DNA deamination (GO:0045006)3.64117556
36male meiosis (GO:0007140)3.63647941
37positive regulation of immunoglobulin mediated immune response (GO:0002891)3.57414490
38positive regulation of B cell mediated immunity (GO:0002714)3.57414490
39leukotriene biosynthetic process (GO:0019370)3.51694324
40positive regulation of immunoglobulin production (GO:0002639)3.46741706
41mast cell degranulation (GO:0043303)3.42912664
42mast cell activation involved in immune response (GO:0002279)3.42912664
43protein complex disassembly (GO:0043241)3.40841299
44SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)3.39154744
45arginine catabolic process (GO:0006527)3.32130227
46cellular response to exogenous dsRNA (GO:0071360)3.28554048
47organic cation transport (GO:0015695)3.25220445
48negative regulation of telomere maintenance (GO:0032205)3.23829505
49translational initiation (GO:0006413)3.22935236
50meiotic chromosome segregation (GO:0045132)3.22230916
51nuclear-transcribed mRNA catabolic process (GO:0000956)3.19766150
52regulation of telomere maintenance via telomerase (GO:0032210)3.17256320
53macromolecular complex disassembly (GO:0032984)3.15342022
54nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)3.14546497
55piRNA metabolic process (GO:0034587)3.13024336
56thyroid hormone generation (GO:0006590)3.09090011
57positive regulation of signal transduction by p53 class mediator (GO:1901798)3.08020334
58behavioral response to nicotine (GO:0035095)3.07361978
59base-excision repair, AP site formation (GO:0006285)3.04341439
60rRNA transcription (GO:0009303)3.04104982
61lymphocyte migration (GO:0072676)3.02495377
62protein targeting to membrane (GO:0006612)3.01334760
63mRNA catabolic process (GO:0006402)2.96045852
64negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.95387391
65regulation of defense response to virus by host (GO:0050691)2.94166080
66mitochondrial respiratory chain complex I assembly (GO:0032981)2.87325299
67NADH dehydrogenase complex assembly (GO:0010257)2.87325299
68mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.87325299
69nucleobase biosynthetic process (GO:0046112)2.86097074
70regulation of natural killer cell mediated immunity (GO:0002715)2.85576612
71regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.85576612
72mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.85157331
73lysosome localization (GO:0032418)2.84164481
74inner mitochondrial membrane organization (GO:0007007)2.78263668
75catecholamine transport (GO:0051937)2.76197142
76pattern specification involved in kidney development (GO:0061004)2.76154482
77pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.75369009
78UMP biosynthetic process (GO:0006222)2.75369009
79pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.75369009
80UMP metabolic process (GO:0046049)2.75369009
81forebrain morphogenesis (GO:0048853)2.71669423
82regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.69332316
83pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.68744524
84arginine metabolic process (GO:0006525)2.67106575
85positive regulation of T cell cytokine production (GO:0002726)2.66129915
86regulation of appetite (GO:0032098)2.64828460
87thyroid hormone metabolic process (GO:0042403)2.63805682
88induction of positive chemotaxis (GO:0050930)2.63180095
89transcription elongation from RNA polymerase III promoter (GO:0006385)2.61876006
90termination of RNA polymerase III transcription (GO:0006386)2.61876006
91kidney morphogenesis (GO:0060993)2.60051298
92DNA methylation involved in gamete generation (GO:0043046)2.59965907
93RNA catabolic process (GO:0006401)2.59921460
94drug transmembrane transport (GO:0006855)2.59230955
95sulfate transmembrane transport (GO:1902358)2.57678083
96epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.56580902
97nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.54081875
98maintenance of protein location in nucleus (GO:0051457)2.53858288
99protein-cofactor linkage (GO:0018065)2.52114354
100cytolysis (GO:0019835)2.52099242

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human4.37337380
2EZH2_22144423_ChIP-Seq_EOC_Human4.22345893
3CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.88537239
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.59934087
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.49806119
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.46042330
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.26603557
8LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.23968914
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.22369142
10VDR_22108803_ChIP-Seq_LS180_Human2.15713174
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08233410
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.00535868
13EED_16625203_ChIP-ChIP_MESCs_Mouse1.82625650
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74521481
15SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72772806
16EZH2_27304074_Chip-Seq_ESCs_Mouse1.72655209
17NOTCH1_21737748_ChIP-Seq_TLL_Human1.72523135
18IRF1_19129219_ChIP-ChIP_H3396_Human1.70854861
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69462964
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65489468
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63842739
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62154766
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.62003026
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.57250197
25ELF1_20517297_ChIP-Seq_JURKAT_Human1.56697300
26YY1_21170310_ChIP-Seq_MESCs_Mouse1.53603113
27TP53_22573176_ChIP-Seq_HFKS_Human1.50513734
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.50154163
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.49445447
30TAF2_19829295_ChIP-Seq_ESCs_Human1.49416646
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47258122
32ZNF274_21170338_ChIP-Seq_K562_Hela1.46418175
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45986139
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45651962
35TDRD3_21172665_ChIP-Seq_MCF-7_Human1.39302375
36AUTS2_25519132_ChIP-Seq_293T-REX_Human1.37496462
37GATA3_21878914_ChIP-Seq_MCF-7_Human1.36736551
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.35686793
39LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34983482
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32538270
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.31263591
42E2F1_20622854_ChIP-Seq_HELA_Human1.30593200
43RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.27775915
44VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.26578394
45GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26082592
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25558494
47STAT1_20625510_ChIP-Seq_HELA_Human1.25505143
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.23652394
49NANOG_20526341_ChIP-Seq_ESCs_Human1.22197085
50TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21116416
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20754903
52FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20562689
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.20562689
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19762748
55CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.18202438
56RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.17026090
57SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16057383
58ERA_21632823_ChIP-Seq_H3396_Human1.16014446
59RNF2_27304074_Chip-Seq_ESCs_Mouse1.15809365
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15515427
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13510189
62EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.13115809
63NCOR_22424771_ChIP-Seq_293T_Human1.12908622
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12737415
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12737415
66GBX2_23144817_ChIP-Seq_PC3_Human1.12612204
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12463583
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.12421201
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12143141
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09523262
71REST_21632747_ChIP-Seq_MESCs_Mouse1.08566291
72IRF8_22096565_ChIP-ChIP_GC-B_Human1.08122435
73SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04176927
74CTCF_20526341_ChIP-Seq_ESCs_Human1.03821824
75SA1_27219007_Chip-Seq_Bcells_Human1.02740609
76ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01353991
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.01231708
78SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00164165
79RUNX_20019798_ChIP-Seq_JUKART_Human0.98972782
80CTCF_27219007_Chip-Seq_Bcells_Human0.98829037
81AR_20517297_ChIP-Seq_VCAP_Human0.98386731
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97336195
83SOX2_21211035_ChIP-Seq_LN229_Human0.97307203
84CBP_20019798_ChIP-Seq_JUKART_Human0.97288613
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97288613
86RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96696694
87MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95587119
88PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94800055
89OCT4_19829295_ChIP-Seq_ESCs_Human0.93466352
90GATA3_26560356_Chip-Seq_TH2_Human0.93215135
91BCAT_22108803_ChIP-Seq_LS180_Human0.93129407
92GATA1_26923725_Chip-Seq_HPCs_Mouse0.92492807
93P53_21459846_ChIP-Seq_SAOS-2_Human0.91588818
94BCL6_27268052_Chip-Seq_Bcells_Human0.91012857
95FOXH1_21741376_ChIP-Seq_ESCs_Human0.90767885
96SOX2_19829295_ChIP-Seq_ESCs_Human0.90040917
97NANOG_19829295_ChIP-Seq_ESCs_Human0.90040917
98GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.89508197
99MYC_19829295_ChIP-Seq_ESCs_Human0.88909550
100GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.88590393

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002132_abnormal_respiratory_system4.97557469
2MP0006082_CNS_inflammation4.70245873
3MP0005623_abnormal_meninges_morphology3.96055400
4MP0005671_abnormal_response_to3.81884606
5MP0009379_abnormal_foot_pigmentation3.64657357
6MP0008995_early_reproductive_senescence2.79264121
7MP0000858_altered_metastatic_potential2.53074798
8MP0002876_abnormal_thyroid_physiology2.33664264
9MP0003786_premature_aging2.25242474
10MP0005408_hypopigmentation2.19106955
11MP0001873_stomach_inflammation2.10081970
12MP0006292_abnormal_olfactory_placode2.08230572
13MP0000013_abnormal_adipose_tissue1.96600734
14MP0004142_abnormal_muscle_tone1.91995679
15MP0009384_cardiac_valve_regurgitation1.76002417
16MP0004885_abnormal_endolymph1.75073433
17MP0001800_abnormal_humoral_immune1.69186687
18MP0003787_abnormal_imprinting1.67768824
19MP0000750_abnormal_muscle_regeneration1.66234532
20MP0002638_abnormal_pupillary_reflex1.63257134
21MP0002837_dystrophic_cardiac_calcinosis1.60058881
22MP0002938_white_spotting1.59635230
23MP0001986_abnormal_taste_sensitivity1.58495778
24MP0008775_abnormal_heart_ventricle1.53974936
25MP0008875_abnormal_xenobiotic_pharmacok1.51773265
26MP0006276_abnormal_autonomic_nervous1.51714696
27MP0002163_abnormal_gland_morphology1.50865262
28MP0003763_abnormal_thymus_physiology1.49531564
29MP0005551_abnormal_eye_electrophysiolog1.49481036
30MP0001968_abnormal_touch/_nociception1.46327416
31MP0009785_altered_susceptibility_to1.37791369
32MP0003646_muscle_fatigue1.37608908
33MP0005645_abnormal_hypothalamus_physiol1.36374970
34MP0009764_decreased_sensitivity_to1.29695421
35MP0002102_abnormal_ear_morphology1.27743704
36MP0001905_abnormal_dopamine_level1.26824063
37MP0009333_abnormal_splenocyte_physiolog1.22100286
38MP0005377_hearing/vestibular/ear_phenot1.20061323
39MP0003878_abnormal_ear_physiology1.20061323
40MP0002736_abnormal_nociception_after1.19019331
41MP0005000_abnormal_immune_tolerance1.16154116
42MP0002653_abnormal_ependyma_morphology1.15926580
43MP0002723_abnormal_immune_serum1.12118439
44MP0010155_abnormal_intestine_physiology1.10006792
45MP0002405_respiratory_system_inflammati1.09116371
46MP0009697_abnormal_copulation1.09036709
47MP0008877_abnormal_DNA_methylation1.06354754
48MP0005167_abnormal_blood-brain_barrier1.03193782
49MP0006072_abnormal_retinal_apoptosis1.00277831
50MP0005423_abnormal_somatic_nervous0.98174315
51MP0005025_abnormal_response_to0.94307468
52MP0002138_abnormal_hepatobiliary_system0.94090501
53MP0003122_maternal_imprinting0.92656815
54MP0001835_abnormal_antigen_presentation0.92380650
55MP0002067_abnormal_sensory_capabilities0.91858002
56MP0000631_abnormal_neuroendocrine_gland0.91503369
57MP0002420_abnormal_adaptive_immunity0.91206135
58MP0001663_abnormal_digestive_system0.90012415
59MP0001819_abnormal_immune_cell0.89125388
60MP0003011_delayed_dark_adaptation0.88290221
61MP0002272_abnormal_nervous_system0.87139312
62MP0004742_abnormal_vestibular_system0.86527142
63MP0004947_skin_inflammation0.86459258
64MP0003880_abnormal_central_pattern0.86034349
65MP0000762_abnormal_tongue_morphology0.85791638
66MP0002277_abnormal_respiratory_mucosa0.85321674
67MP0005195_abnormal_posterior_eye0.85045305
68MP0003866_abnormal_defecation0.84906751
69MP0008469_abnormal_protein_level0.83523778
70MP0008872_abnormal_physiological_respon0.83305655
71MP0003186_abnormal_redox_activity0.83282729
72MP0009745_abnormal_behavioral_response0.83118185
73MP0002933_joint_inflammation0.82187913
74MP0005379_endocrine/exocrine_gland_phen0.82119010
75MP0008770_decreased_survivor_rate0.82085390
76MP0005410_abnormal_fertilization0.81175173
77MP0003252_abnormal_bile_duct0.79972574
78MP0003638_abnormal_response/metabolism_0.79098472
79MP0003136_yellow_coat_color0.78192426
80MP0000685_abnormal_immune_system0.77304792
81MP0001790_abnormal_immune_system0.76320436
82MP0005387_immune_system_phenotype0.76320436
83MP0002452_abnormal_antigen_presenting0.76199819
84MP0004130_abnormal_muscle_cell0.75378919
85MP0004145_abnormal_muscle_electrophysio0.74513066
86MP0001119_abnormal_female_reproductive0.74245571
87MP0003718_maternal_effect0.73345048
88MP0002735_abnormal_chemical_nociception0.72033548
89MP0000049_abnormal_middle_ear0.71294055
90MP0002184_abnormal_innervation0.70294760
91MP0005084_abnormal_gallbladder_morpholo0.70018500
92MP0010307_abnormal_tumor_latency0.69567253
93MP0000230_abnormal_systemic_arterial0.69122415
94MP0002572_abnormal_emotion/affect_behav0.69093243
95MP0009046_muscle_twitch0.68707920
96MP0001485_abnormal_pinna_reflex0.65802758
97MP0005646_abnormal_pituitary_gland0.65586443
98MP0003121_genomic_imprinting0.65327110
99MP0004147_increased_porphyrin_level0.63438607
100MP0001845_abnormal_inflammatory_respons0.63261489

Predicted human phenotypes

RankGene SetZ-score
1Retinal atrophy (HP:0001105)7.30658195
2Cerebellar dysplasia (HP:0007033)7.04791883
3Type II lissencephaly (HP:0007260)6.60332828
4Abnormality of pyrimidine metabolism (HP:0004353)5.68237863
5Hypoplasia of the pons (HP:0012110)5.26841901
6Retinal dysplasia (HP:0007973)5.14678263
7Abnormality of DNA repair (HP:0003254)4.96323371
8Abnormality of the pons (HP:0007361)4.89789142
9Reticulocytopenia (HP:0001896)4.79865300
10Decreased electroretinogram (ERG) amplitude (HP:0000654)4.41504532
11Buphthalmos (HP:0000557)4.11051596
12Nasal polyposis (HP:0100582)4.05554530
13Fatigue (HP:0012378)4.03510637
14Abolished electroretinogram (ERG) (HP:0000550)4.03152524
15Increased IgM level (HP:0003496)3.87206050
16Elevated erythrocyte sedimentation rate (HP:0003565)3.85116060
17Aplasia/Hypoplasia affecting the retina (HP:0008061)3.71808083
18Duplicated collecting system (HP:0000081)3.60366752
19Abnormality of the renal collecting system (HP:0004742)3.45468815
20Abnormality of the nasal mucosa (HP:0000433)3.27804944
21Megalocornea (HP:0000485)3.14134271
22IgG deficiency (HP:0004315)3.08541910
23Pallor (HP:0000980)3.06251497
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.04171519
25Absent thumb (HP:0009777)2.84843008
26Zonular cataract (HP:0010920)2.72591463
27Severe muscular hypotonia (HP:0006829)2.66518319
28Entropion (HP:0000621)2.65431876
29Difficulty climbing stairs (HP:0003551)2.62284904
30Molar tooth sign on MRI (HP:0002419)2.61721573
31Abnormality of midbrain morphology (HP:0002418)2.61721573
32Nephronophthisis (HP:0000090)2.61551837
33Lissencephaly (HP:0001339)2.55863456
34Colon cancer (HP:0003003)2.48960038
35Chromsome breakage (HP:0040012)2.48145832
36Macrocytic anemia (HP:0001972)2.47391177
37Abnormality of T cells (HP:0002843)2.40760350
38Abnormality of monocarboxylic acid metabolism (HP:0010996)2.39788088
39Oral leukoplakia (HP:0002745)2.36694723
40Eosinophilia (HP:0001880)2.35363495
41Abnormality of cells of the erythroid lineage (HP:0012130)2.33731141
42Stomach cancer (HP:0012126)2.24761917
43Congenital glaucoma (HP:0001087)2.23212880
44Ectopic kidney (HP:0000086)2.22655080
45Pancreatic fibrosis (HP:0100732)2.19509546
46Abnormality of T cell physiology (HP:0011840)2.19186813
47Pachygyria (HP:0001302)2.16956477
48Abnormality of the renal medulla (HP:0100957)2.16386774
49Abnormality of the renal cortex (HP:0011035)2.10263900
50Erythroderma (HP:0001019)2.09618851
51Conical tooth (HP:0000698)2.09591464
523-Methylglutaconic aciduria (HP:0003535)2.08431309
53Abnormality of eosinophils (HP:0001879)2.06078340
54Stenosis of the external auditory canal (HP:0000402)2.05819651
55Aplastic anemia (HP:0001915)2.03766983
56Abnormal drinking behavior (HP:0030082)2.02928452
57Polydipsia (HP:0001959)2.02928452
58Thrombocytosis (HP:0001894)2.01642766
59Poikiloderma (HP:0001029)2.00280483
60Meningocele (HP:0002435)1.99745223
61Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.97807425
62Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.97091553
63Ureteral duplication (HP:0000073)1.95810919
64Papilledema (HP:0001085)1.93530145
65Pancreatic cysts (HP:0001737)1.93313475
66Aplasia/Hypoplasia of the spleen (HP:0010451)1.93026397
67Agitation (HP:0000713)1.91352086
68Abnormality of T cell number (HP:0011839)1.90876919
69Hypergammaglobulinemia (HP:0010702)1.89624850
70Asplenia (HP:0001746)1.87476909
71Diaphragmatic weakness (HP:0009113)1.86111460
72Abnormality of nucleobase metabolism (HP:0010932)1.85313695
73Intellectual disability, profound (HP:0002187)1.84824406
74Polyuria (HP:0000103)1.83920741
75True hermaphroditism (HP:0010459)1.82480330
76Thyroid-stimulating hormone excess (HP:0002925)1.82479165
77Hypoproteinemia (HP:0003075)1.81814163
78Duplication of thumb phalanx (HP:0009942)1.81668427
79Increased serum pyruvate (HP:0003542)1.79389321
80Acute necrotizing encephalopathy (HP:0006965)1.77987468
81Hypoplasia of the brainstem (HP:0002365)1.77985262
82Aplasia/Hypoplasia of the brainstem (HP:0007362)1.77985262
83Fragile nails (HP:0001808)1.76441126
84Poikilocytosis (HP:0004447)1.76121097
85Medial flaring of the eyebrow (HP:0010747)1.75951432
86Keratitis (HP:0000491)1.75764954
87Pancytopenia (HP:0001876)1.75712062
88Stomatitis (HP:0010280)1.75630208
89Mesangial abnormality (HP:0001966)1.74940179
90Aplasia/Hypoplasia of the uvula (HP:0010293)1.71905648
91Congenital stationary night blindness (HP:0007642)1.69892524
92Abnormality of the vitreous humor (HP:0004327)1.68831845
93Generalized muscle weakness (HP:0003324)1.66794838
94Myositis (HP:0100614)1.66754112
95Horseshoe kidney (HP:0000085)1.65475173
96Megaloblastic anemia (HP:0001889)1.63838782
97Hypoalbuminemia (HP:0003073)1.63725244
98Abnormal albumin level (HP:0012116)1.63725244
99Synostosis of carpal bones (HP:0005048)1.63530825
100Absent rod-and cone-mediated responses on ERG (HP:0007688)1.63119762

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK36.36710447
2TXK5.55005013
3MAP4K14.41982742
4MARK33.90626299
5BCKDK3.59991379
6STK103.41652395
7ITK3.19449900
8PTK2B3.06847942
9WNK42.54973131
10ZAP702.52660633
11PIM12.32183541
12CDK191.86924095
13PIK3CA1.71177323
14STK111.53964704
15STK391.52592470
16TIE11.50795817
17ADRBK21.44518519
18GRK11.43723158
19MAP4K21.33716609
20MAP3K121.30432155
21TLK11.25330256
22MUSK1.14912147
23GSK3A1.13859802
24INSRR1.12425096
25SYK1.05348715
26FRK1.03984111
27PINK10.99770577
28PRKG20.99463375
29TBK10.98581006
30FES0.98110038
31NUAK10.97336471
32CAMKK20.94055833
33DYRK20.93272648
34BMPR1B0.92922818
35PRKCH0.92430239
36MAPK70.91769158
37IKBKB0.87446876
38BTK0.80211871
39MYLK0.79500796
40NLK0.78368016
41TYRO30.76916222
42OXSR10.73649419
43WNK10.73434086
44MAP2K20.73025942
45CHEK20.72304423
46MAP3K70.72118129
47LCK0.71850816
48KDR0.64822883
49PRKCQ0.64379002
50DAPK30.58660660
51VRK10.56670051
52LYN0.56159338
53CSNK1A10.55296972
54OBSCN0.52849347
55STK160.52715065
56WNK30.52663023
57ZAK0.52656652
58LMTK20.51555586
59PRKCG0.51278258
60MAP3K130.50858019
61PIK3CG0.48768145
62TESK20.48752066
63CAMK1D0.47499431
64NTRK20.47279011
65PRKAA20.42928064
66SGK10.42188646
67IKBKE0.41808836
68RPS6KA50.40301692
69TEC0.40001569
70CAMKK10.39494556
71LRRK20.39024207
72CDK40.38817055
73MAPK150.38731512
74IGF1R0.37525291
75CSNK1G10.36342875
76HCK0.35278968
77ADRBK10.34140427
78PRKACA0.33797458
79KIT0.33426232
80GRK60.33405662
81CAMK10.33120623
82PRKCZ0.33094822
83PRKCA0.31881910
84PHKG20.31731826
85PHKG10.31731826
86CSNK1G30.31053247
87CSNK1A1L0.30554588
88GRK70.30404856
89RPS6KA60.28606481
90MAPK130.28418471
91DAPK10.27735291
92PRKCE0.27468584
93PRKACG0.26802060
94FYN0.26185782
95PRKCD0.25308321
96PKN10.23732640
97GRK50.22887436
98PIM20.22635829
99NME20.22452034
100CSNK1G20.22283151

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.87563922
2Graft-versus-host disease_Homo sapiens_hsa053324.58682846
3Allograft rejection_Homo sapiens_hsa053303.16873352
4Autoimmune thyroid disease_Homo sapiens_hsa053202.94707983
5Asthma_Homo sapiens_hsa053102.72620997
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.52504413
7Oxidative phosphorylation_Homo sapiens_hsa001902.41387372
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.41056713
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11909234
10Type I diabetes mellitus_Homo sapiens_hsa049402.08917360
11Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.92101203
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.87902130
13Antigen processing and presentation_Homo sapiens_hsa046121.86292467
14Primary immunodeficiency_Homo sapiens_hsa053401.85299485
15Parkinsons disease_Homo sapiens_hsa050121.82735161
16Linoleic acid metabolism_Homo sapiens_hsa005911.78157015
17Cardiac muscle contraction_Homo sapiens_hsa042601.75764124
18RNA polymerase_Homo sapiens_hsa030201.59567431
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.56612417
20SNARE interactions in vesicular transport_Homo sapiens_hsa041301.53479294
21Basal transcription factors_Homo sapiens_hsa030221.49849518
22Viral myocarditis_Homo sapiens_hsa054161.46318698
23RNA degradation_Homo sapiens_hsa030181.40583381
24Sulfur relay system_Homo sapiens_hsa041221.40123749
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39519240
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.36584407
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.36505008
28Staphylococcus aureus infection_Homo sapiens_hsa051501.33155881
29Leishmaniasis_Homo sapiens_hsa051401.29575042
30Rheumatoid arthritis_Homo sapiens_hsa053231.28581929
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23360511
32Phototransduction_Homo sapiens_hsa047441.20000448
33Pyrimidine metabolism_Homo sapiens_hsa002401.19818590
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17228772
35Huntingtons disease_Homo sapiens_hsa050161.14599020
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07879670
37T cell receptor signaling pathway_Homo sapiens_hsa046601.02395268
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02302879
39Alzheimers disease_Homo sapiens_hsa050100.99105415
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98623833
41Steroid hormone biosynthesis_Homo sapiens_hsa001400.97732343
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96221687
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95848672
44Chemical carcinogenesis_Homo sapiens_hsa052040.94868441
45Caffeine metabolism_Homo sapiens_hsa002320.92471201
46Hematopoietic cell lineage_Homo sapiens_hsa046400.91468362
47Fanconi anemia pathway_Homo sapiens_hsa034600.87193486
48Nicotine addiction_Homo sapiens_hsa050330.83925672
49Protein export_Homo sapiens_hsa030600.82689665
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81678250
51Malaria_Homo sapiens_hsa051440.78379356
52Ether lipid metabolism_Homo sapiens_hsa005650.75196847
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74878438
54Arachidonic acid metabolism_Homo sapiens_hsa005900.73315167
55Butanoate metabolism_Homo sapiens_hsa006500.72240550
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72022527
57Systemic lupus erythematosus_Homo sapiens_hsa053220.71249556
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70511220
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70343602
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70284491
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69659121
62Retinol metabolism_Homo sapiens_hsa008300.69244745
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69097342
64Fat digestion and absorption_Homo sapiens_hsa049750.65591429
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65265005
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65104639
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.64467962
68Nitrogen metabolism_Homo sapiens_hsa009100.62359651
69Peroxisome_Homo sapiens_hsa041460.59432313
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57557168
71Olfactory transduction_Homo sapiens_hsa047400.57492087
72Morphine addiction_Homo sapiens_hsa050320.57246069
73TNF signaling pathway_Homo sapiens_hsa046680.55436239
74One carbon pool by folate_Homo sapiens_hsa006700.53420152
75Tryptophan metabolism_Homo sapiens_hsa003800.52952117
76Ovarian steroidogenesis_Homo sapiens_hsa049130.50003159
77Taste transduction_Homo sapiens_hsa047420.46750906
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.46677804
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46495994
80Propanoate metabolism_Homo sapiens_hsa006400.44692565
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44532773
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44110752
83Toxoplasmosis_Homo sapiens_hsa051450.41675731
84Arginine biosynthesis_Homo sapiens_hsa002200.40906390
85Insulin secretion_Homo sapiens_hsa049110.40005894
86Purine metabolism_Homo sapiens_hsa002300.37836890
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.37659861
88beta-Alanine metabolism_Homo sapiens_hsa004100.37234778
89Proteasome_Homo sapiens_hsa030500.36798457
90Homologous recombination_Homo sapiens_hsa034400.34554094
91Metabolic pathways_Homo sapiens_hsa011000.34550087
92Mineral absorption_Homo sapiens_hsa049780.32666574
93Regulation of autophagy_Homo sapiens_hsa041400.32253874
94Base excision repair_Homo sapiens_hsa034100.31449777
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30281588
96Nucleotide excision repair_Homo sapiens_hsa034200.29501178
97Salivary secretion_Homo sapiens_hsa049700.29383531
98Bile secretion_Homo sapiens_hsa049760.28414720
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25358186
100MAPK signaling pathway_Homo sapiens_hsa040100.25219050

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