ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	8.42207814
2	viral transcription (GO:0019083)	8.18108520
3	ribosomal small subunit biogenesis (GO:0042274)	7.98695934
4	translational termination (GO:0006415)	7.83578937
5	maturation of SSU-rRNA (GO:0030490)	6.74642691
6	translational elongation (GO:0006414)	6.65929573
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.60400188
8	cotranslational protein targeting to membrane (GO:0006613)	6.49912666
9	protein targeting to ER (GO:0045047)	6.47925670
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.16788259
11	protein localization to endoplasmic reticulum (GO:0070972)	6.09263040
12	cellular protein complex disassembly (GO:0043624)	5.92134807
13	viral life cycle (GO:0019058)	5.73556106
14	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.63238476
15	DNA deamination (GO:0045006)	5.25493564
16	ATP synthesis coupled proton transport (GO:0015986)	5.19700827
17	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.19700827
18	translational initiation (GO:0006413)	5.13421127
19	protein complex disassembly (GO:0043241)	4.96603883
20	protein neddylation (GO:0045116)	4.95446494
21	protein complex biogenesis (GO:0070271)	4.74365802
22	macromolecular complex disassembly (GO:0032984)	4.69178259
23	ribosomal large subunit biogenesis (GO:0042273)	4.55986410
24	chaperone-mediated protein transport (GO:0072321)	4.52810040
25	translation (GO:0006412)	4.39502723
26	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.35555567
27	mitochondrial respiratory chain complex assembly (GO:0033108)	4.33469906
28	behavioral response to nicotine (GO:0035095)	4.33017657
29	protein targeting to membrane (GO:0006612)	4.30356046
30	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.26958492
31	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.26958492
32	NADH dehydrogenase complex assembly (GO:0010257)	4.26958492
33	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.21837228
34	respiratory electron transport chain (GO:0022904)	4.10084729
35	electron transport chain (GO:0022900)	4.09408515
36	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.03745623
37	pseudouridine synthesis (GO:0001522)	3.99433772
38	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.96671952
39	cellular component biogenesis (GO:0044085)	3.91032629
40	regulation of mitochondrial translation (GO:0070129)	3.79758040
41	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.77696567
42	mRNA catabolic process (GO:0006402)	3.74739625
43	ribonucleoprotein complex biogenesis (GO:0022613)	3.74415393
44	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.73166028
45	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.62507831
46	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.62507831
47	pyrimidine nucleotide catabolic process (GO:0006244)	3.59120926
48	water-soluble vitamin biosynthetic process (GO:0042364)	3.47790484
49	cytochrome complex assembly (GO:0017004)	3.44234979
50	RNA catabolic process (GO:0006401)	3.37712440
51	rRNA processing (GO:0006364)	3.28247917
52	rRNA metabolic process (GO:0016072)	3.27988537
53	base-excision repair, AP site formation (GO:0006285)	3.25394802
54	cytidine metabolic process (GO:0046087)	3.18360762
55	cytidine catabolic process (GO:0006216)	3.18360762
56	cytidine deamination (GO:0009972)	3.18360762
57	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.10014805
58	maturation of 5.8S rRNA (GO:0000460)	3.09478575
59	ncRNA 3-end processing (GO:0043628)	3.00282351
60	ATP biosynthetic process (GO:0006754)	2.98924744
61	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	2.97533133
62	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.97482073
63	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.95525578
64	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.95458528
65	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.95179744
66	platelet dense granule organization (GO:0060155)	2.88205044
67	hydrogen ion transmembrane transport (GO:1902600)	2.87016380
68	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.86737021
69	establishment of protein localization to membrane (GO:0090150)	2.86173139
70	GTP biosynthetic process (GO:0006183)	2.83320578
71	respiratory chain complex IV assembly (GO:0008535)	2.83201035
72	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.81964340
73	positive regulation of T cell apoptotic process (GO:0070234)	2.79910252
74	signal complex assembly (GO:0007172)	2.78786419
75	positive regulation of prostaglandin secretion (GO:0032308)	2.74730294
76	piRNA metabolic process (GO:0034587)	2.73423889
77	deoxyribonucleotide catabolic process (GO:0009264)	2.73151192
78	proton transport (GO:0015992)	2.72579430
79	substrate-independent telencephalic tangential migration (GO:0021826)	2.71502180
80	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.71502180
81	protein targeting (GO:0006605)	2.68830577
82	ubiquinone biosynthetic process (GO:0006744)	2.67987486
83	hydrogen transport (GO:0006818)	2.65929682
84	tRNA processing (GO:0008033)	2.63832511
85	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.63651417
86	rRNA modification (GO:0000154)	2.58954465
87	deoxyribose phosphate catabolic process (GO:0046386)	2.57946887
88	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.57144429
89	establishment of protein localization to organelle (GO:0072594)	2.56492062
90	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.55555447
91	termination of RNA polymerase III transcription (GO:0006386)	2.55555447
92	positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)	2.55462410
93	negative regulation of telomere maintenance (GO:0032205)	2.55338917
94	sequestering of actin monomers (GO:0042989)	2.54976192
95	metallo-sulfur cluster assembly (GO:0031163)	2.54124501
96	iron-sulfur cluster assembly (GO:0016226)	2.54124501
97	positive regulation of fatty acid transport (GO:2000193)	2.53661652
98	ncRNA processing (GO:0034470)	2.48092428
99	secretory granule organization (GO:0033363)	2.47322356
100	protein peptidyl-prolyl isomerization (GO:0000413)	2.46816018

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.44282030
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.36132791
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.09857736
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.48117927
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.99368267
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.93992799
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.81189274
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.75539585
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.65064073
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.47330421
11	VDR_22108803_ChIP-Seq_LS180_Human	2.46151398
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.03131052
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.95691694
14	VDR_23849224_ChIP-Seq_CD4+_Human	1.85950021
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.82835778
16	ZNF274_21170338_ChIP-Seq_K562_Hela	1.80047186
17	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.78313977
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.77679335
19	MYC_18940864_ChIP-ChIP_HL60_Human	1.77132473
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.69337099
21	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.59634341
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.58160997
23	IRF1_19129219_ChIP-ChIP_H3396_Human	1.56982791
24	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.56121641
25	FOXP3_21729870_ChIP-Seq_TREG_Human	1.52848806
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.51398116
27	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.51060034
28	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.50966068
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.49449908
30	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.49156465
31	NANOG_20526341_ChIP-Seq_ESCs_Human	1.45868269
32	TAF2_19829295_ChIP-Seq_ESCs_Human	1.44476688
33	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.42920590
34	TTF2_22483619_ChIP-Seq_HELA_Human	1.41786435
35	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.37992199
36	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.37949497
37	XRN2_22483619_ChIP-Seq_HELA_Human	1.37386355
38	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.37288448
39	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.37100953
40	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.36913444
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.33318471
42	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.32753794
43	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.32657891
44	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.31230351
45	ERA_21632823_ChIP-Seq_H3396_Human	1.30041257
46	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.29647464
47	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.25981223
48	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.25252956
49	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.23188307
50	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.22395847
51	ELK1_19687146_ChIP-ChIP_HELA_Human	1.22253465
52	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.22123493
53	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.21028546
54	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.20865380
55	RNF2_27304074_Chip-Seq_NSC_Mouse	1.20112394
56	CTCF_20526341_ChIP-Seq_ESCs_Human	1.19547030
57	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.19462135
58	GABP_19822575_ChIP-Seq_HepG2_Human	1.19216591
59	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.19085438
60	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.18964487
61	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.16403658
62	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.15551328
63	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.15532859
64	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.15511801
65	BCL6_27268052_Chip-Seq_Bcells_Human	1.15348562
66	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.14032109
67	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13657934
68	AR_20517297_ChIP-Seq_VCAP_Human	1.11544975
69	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.11129273
70	NCOR_22424771_ChIP-Seq_293T_Human	1.10407185
71	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.09657806
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09616189
73	STAT1_20625510_ChIP-Seq_HELA_Human	1.04956256
74	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.04890523
75	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.04036623
76	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.03833069
77	IGF1R_20145208_ChIP-Seq_DFB_Human	1.03312491
78	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.01989309
79	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.01938197
80	MYC_19829295_ChIP-Seq_ESCs_Human	1.01695976
81	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.01306529
82	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.00359842
83	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.00324559
84	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.99250381
85	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.98487027
86	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.98289136
87	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.97696348
88	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.96887482
89	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.96402946
90	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.95945272
91	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.95144144
92	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.95106120
93	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.94580182
94	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.94497715
95	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.93399936
96	SA1_27219007_Chip-Seq_Bcells_Human	0.92990319
97	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.92770044
98	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.92770044
99	REST_21632747_ChIP-Seq_MESCs_Mouse	0.90601068
100	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.89814091

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.89828925
2	MP0006292_abnormal_olfactory_placode	4.08497162
3	MP0003646_muscle_fatigue	3.09114436
4	MP0002163_abnormal_gland_morphology	2.89541241
5	MP0002102_abnormal_ear_morphology	2.62676205
6	MP0004145_abnormal_muscle_electrophysio	2.55669912
7	MP0005671_abnormal_response_to	2.45050086
8	MP0005646_abnormal_pituitary_gland	2.43237000
9	MP0005377_hearing/vestibular/ear_phenot	2.27370246
10	MP0003878_abnormal_ear_physiology	2.27370246
11	MP0004142_abnormal_muscle_tone	2.18326864
12	MP0008789_abnormal_olfactory_epithelium	2.08378957
13	MP0008877_abnormal_DNA_methylation	2.01607239
14	MP0003122_maternal_imprinting	1.97965914
15	MP0005645_abnormal_hypothalamus_physiol	1.84819690
16	MP0003787_abnormal_imprinting	1.83596835
17	MP0001905_abnormal_dopamine_level	1.82955296
18	MP0001968_abnormal_touch/_nociception	1.81975344
19	MP0006072_abnormal_retinal_apoptosis	1.73277488
20	MP0002876_abnormal_thyroid_physiology	1.72983909
21	MP0005551_abnormal_eye_electrophysiolog	1.69337249
22	MP0008872_abnormal_physiological_respon	1.66571686
23	MP0008875_abnormal_xenobiotic_pharmacok	1.65866531
24	MP0005379_endocrine/exocrine_gland_phen	1.63257051
25	MP0004147_increased_porphyrin_level	1.60525467
26	MP0001986_abnormal_taste_sensitivity	1.60337333
27	MP0004885_abnormal_endolymph	1.59569742
28	MP0005394_taste/olfaction_phenotype	1.48281273
29	MP0005499_abnormal_olfactory_system	1.48281273
30	MP0006276_abnormal_autonomic_nervous	1.47821434
31	MP0002638_abnormal_pupillary_reflex	1.42685350
32	MP0002160_abnormal_reproductive_system	1.40660292
33	MP0001529_abnormal_vocalization	1.36416043
34	MP0000049_abnormal_middle_ear	1.35997326
35	MP0002272_abnormal_nervous_system	1.34145709
36	MP0005389_reproductive_system_phenotype	1.32997479
37	MP0002736_abnormal_nociception_after	1.25092862
38	MP0003011_delayed_dark_adaptation	1.24781826
39	MP0005410_abnormal_fertilization	1.24638893
40	MP0001188_hyperpigmentation	1.23355603
41	MP0002138_abnormal_hepatobiliary_system	1.23156219
42	MP0002837_dystrophic_cardiac_calcinosis	1.22504797
43	MP0002277_abnormal_respiratory_mucosa	1.21900318
44	MP0000631_abnormal_neuroendocrine_gland	1.21322165
45	MP0001984_abnormal_olfaction	1.21174079
46	MP0000372_irregular_coat_pigmentation	1.20404041
47	MP0001293_anophthalmia	1.19055325
48	MP0009745_abnormal_behavioral_response	1.18658370
49	MP0003123_paternal_imprinting	1.17886536
50	MP0005084_abnormal_gallbladder_morpholo	1.15707544
51	MP0003121_genomic_imprinting	1.14902498
52	MP0001970_abnormal_pain_threshold	1.14442057
53	MP0002733_abnormal_thermal_nociception	1.13625285
54	MP0002938_white_spotting	1.12275874
55	MP0002653_abnormal_ependyma_morphology	1.09943460
56	MP0002234_abnormal_pharynx_morphology	1.09193548
57	MP0001440_abnormal_grooming_behavior	1.08588706
58	MP0009764_decreased_sensitivity_to	1.07610382
59	MP0003567_abnormal_fetal_cardiomyocyte	1.06343568
60	MP0002557_abnormal_social/conspecific_i	1.04769836
61	MP0000685_abnormal_immune_system	1.03821797
62	MP0002095_abnormal_skin_pigmentation	1.02372703
63	MP0001919_abnormal_reproductive_system	1.01815561
64	MP0009046_muscle_twitch	0.99010890
65	MP0004742_abnormal_vestibular_system	0.97273794
66	MP0003186_abnormal_redox_activity	0.90809456
67	MP0002148_abnormal_hypersensitivity_rea	0.90730941
68	MP0001485_abnormal_pinna_reflex	0.89567108
69	MP0005195_abnormal_posterior_eye	0.89119598
70	MP0003136_yellow_coat_color	0.89087167
71	MP0006036_abnormal_mitochondrial_physio	0.88411337
72	MP0002735_abnormal_chemical_nociception	0.86932653
73	MP0003880_abnormal_central_pattern	0.86840420
74	MP0002572_abnormal_emotion/affect_behav	0.85297574
75	MP0001800_abnormal_humoral_immune	0.84586636
76	MP0009333_abnormal_splenocyte_physiolog	0.84260250
77	MP0006035_abnormal_mitochondrial_morpho	0.83981593
78	MP0005075_abnormal_melanosome_morpholog	0.83812363
79	MP0002752_abnormal_somatic_nervous	0.82003829
80	MP0003786_premature_aging	0.78559141
81	MP0002063_abnormal_learning/memory/cond	0.78486662
82	MP0002184_abnormal_innervation	0.76475525
83	MP0000026_abnormal_inner_ear	0.75817566
84	MP0001486_abnormal_startle_reflex	0.75569948
85	MP0005387_immune_system_phenotype	0.75558690
86	MP0001790_abnormal_immune_system	0.75558690
87	MP0005253_abnormal_eye_physiology	0.75534908
88	MP0003195_calcinosis	0.73074182
89	MP0003938_abnormal_ear_development	0.72936632
90	MP0003635_abnormal_synaptic_transmissio	0.72689641
91	MP0001963_abnormal_hearing_physiology	0.72243888
92	MP0009785_altered_susceptibility_to	0.70563449
93	MP0002210_abnormal_sex_determination	0.69325215
94	MP0002723_abnormal_immune_serum	0.69082399
95	MP0003879_abnormal_hair_cell	0.68677615
96	MP0000230_abnormal_systemic_arterial	0.68490466
97	MP0002067_abnormal_sensory_capabilities	0.68290807
98	MP0004133_heterotaxia	0.66585716
99	MP0008995_early_reproductive_senescence	0.64866918
100	MP0002420_abnormal_adaptive_immunity	0.64765090

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.88185959
2	Acute necrotizing encephalopathy (HP:0006965)	4.51359708
3	Abnormality of cells of the erythroid lineage (HP:0012130)	4.32457599
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.20123609
5	Macrocytic anemia (HP:0001972)	4.05592014
6	Mitochondrial inheritance (HP:0001427)	4.00638911
7	Acute encephalopathy (HP:0006846)	3.70418598
8	Congenital stationary night blindness (HP:0007642)	3.65857011
9	Abnormal number of erythroid precursors (HP:0012131)	3.63739572
10	Progressive macrocephaly (HP:0004481)	3.60527518
11	3-Methylglutaconic aciduria (HP:0003535)	3.59963868
12	Increased CSF lactate (HP:0002490)	3.55872511
13	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.48496933
14	Abnormality of midbrain morphology (HP:0002418)	3.42193824
15	Molar tooth sign on MRI (HP:0002419)	3.42193824
16	Pallor (HP:0000980)	3.32823206
17	Increased intramyocellular lipid droplets (HP:0012240)	3.17508765
18	Hepatocellular necrosis (HP:0001404)	3.17358821
19	Increased IgM level (HP:0003496)	3.14940596
20	Increased hepatocellular lipid droplets (HP:0006565)	3.07341079
21	Pancreatic fibrosis (HP:0100732)	3.00991069
22	Hepatic necrosis (HP:0002605)	2.93926059
23	Abnormal rod and cone electroretinograms (HP:0008323)	2.93529465
24	Lipid accumulation in hepatocytes (HP:0006561)	2.91082654
25	Pancreatic cysts (HP:0001737)	2.85124274
26	Renal Fanconi syndrome (HP:0001994)	2.83838671
27	IgG deficiency (HP:0004315)	2.80232985
28	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.76723044
29	Cerebral edema (HP:0002181)	2.72373191
30	Increased muscle lipid content (HP:0009058)	2.70490434
31	Pendular nystagmus (HP:0012043)	2.70336234
32	Aplastic anemia (HP:0001915)	2.69477537
33	Asplenia (HP:0001746)	2.69375412
34	Absent thumb (HP:0009777)	2.64891171
35	Abnormality of the renal cortex (HP:0011035)	2.63046312
36	Type II lissencephaly (HP:0007260)	2.62914392
37	Nephronophthisis (HP:0000090)	2.54159950
38	Renal cortical cysts (HP:0000803)	2.53854676
39	Agitation (HP:0000713)	2.50276069
40	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.45666985
41	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.45666985
42	Optic disc pallor (HP:0000543)	2.41745805
43	Increased serum lactate (HP:0002151)	2.38503072
44	Colon cancer (HP:0003003)	2.34057114
45	Methylmalonic acidemia (HP:0002912)	2.33312084
46	Lactic acidosis (HP:0003128)	2.31308823
47	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.29805320
48	Abnormality of alanine metabolism (HP:0010916)	2.29805320
49	Hyperalaninemia (HP:0003348)	2.29805320
50	Septo-optic dysplasia (HP:0100842)	2.24286842
51	Medial flaring of the eyebrow (HP:0010747)	2.24064378
52	True hermaphroditism (HP:0010459)	2.23287879
53	Abolished electroretinogram (ERG) (HP:0000550)	2.18066773
54	Type 2 muscle fiber atrophy (HP:0003554)	2.16693016
55	Stenosis of the external auditory canal (HP:0000402)	2.16331302
56	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.13249325
57	Abnormal drinking behavior (HP:0030082)	2.13053396
58	Polydipsia (HP:0001959)	2.13053396
59	Abnormality of the renal medulla (HP:0100957)	2.11320559
60	Decreased central vision (HP:0007663)	2.10601999
61	Hypoplasia of the radius (HP:0002984)	2.09428739
62	Exertional dyspnea (HP:0002875)	2.08033188
63	Pancytopenia (HP:0001876)	2.07994294
64	Respiratory failure (HP:0002878)	2.07753307
65	Hyperglycinemia (HP:0002154)	2.06031183
66	Methylmalonic aciduria (HP:0012120)	2.03325258
67	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.02030755
68	Depressed nasal ridge (HP:0000457)	1.98886779
69	Cystic liver disease (HP:0006706)	1.97666348
70	Abnormal hemoglobin (HP:0011902)	1.93651078
71	Concave nail (HP:0001598)	1.92327401
72	Muscle fiber atrophy (HP:0100295)	1.90673689
73	Lethargy (HP:0001254)	1.90374666
74	Increased corneal curvature (HP:0100692)	1.89869282
75	Keratoconus (HP:0000563)	1.89869282
76	Myokymia (HP:0002411)	1.89731300
77	Abnormality of renal resorption (HP:0011038)	1.89576394
78	Tubular atrophy (HP:0000092)	1.89427910
79	Leukodystrophy (HP:0002415)	1.87788490
80	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.86818411
81	Exercise intolerance (HP:0003546)	1.86470645
82	Polyuria (HP:0000103)	1.85044417
83	Gait imbalance (HP:0002141)	1.83638758
84	Glycosuria (HP:0003076)	1.83635379
85	Abnormality of urine glucose concentration (HP:0011016)	1.83635379
86	Elevated erythrocyte sedimentation rate (HP:0003565)	1.82700785
87	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.80012079
88	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.79963041
89	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.78715160
90	Radial bowing (HP:0002986)	1.78709656
91	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.76000553
92	Forearm undergrowth (HP:0009821)	1.75949483
93	Microretrognathia (HP:0000308)	1.72797918
94	Stomatitis (HP:0010280)	1.71001527
95	Supernumerary spleens (HP:0009799)	1.70517514
96	Hypoplasia of the uterus (HP:0000013)	1.70117106
97	Testicular atrophy (HP:0000029)	1.69417611
98	Cleft eyelid (HP:0000625)	1.68375416
99	Severe combined immunodeficiency (HP:0004430)	1.68325948
100	Hyperphosphaturia (HP:0003109)	1.66980528

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.17457477
2	ADRBK2	2.89677827
3	TLK1	2.82634998
4	STK16	2.73934502
5	TESK2	2.72934603
6	KDR	2.67605093
7	RIPK1	2.67196440
8	WNK4	2.58874678
9	PASK	2.56975989
10	PINK1	2.43801560
11	MAP4K2	2.35967375
12	GRK1	2.23860394
13	TIE1	2.14977896
14	BCKDK	2.11166482
15	DYRK2	2.04144357
16	CDK19	1.99714769
17	NUAK1	1.96206118
18	ZAK	1.95092578
19	MAP4K1	1.90035336
20	VRK2	1.89913767
21	TAOK3	1.89157701
22	PLK4	1.74366765
23	PRKCI	1.70887338
24	NME2	1.64517834
25	LRRK2	1.47896459
26	MUSK	1.47530804
27	MAP3K11	1.33595330
28	PDK2	1.32979246
29	VRK1	1.22464006
30	PRKCG	1.20185129
31	WNK3	1.18651160
32	CAMKK1	1.13327662
33	CAMKK2	1.12531491
34	DAPK3	1.12345834
35	BUB1	1.11475997
36	NME1	1.06499125
37	PRKCQ	1.04073617
38	IKBKB	1.03956316
39	NEK1	0.99051612
40	ITK	0.97574035
41	FRK	0.97116383
42	MAPKAPK3	0.96553193
43	IKBKE	0.95396123
44	PHKG2	0.95324067
45	PHKG1	0.95324067
46	TEC	0.89828275
47	STK39	0.85746121
48	PIK3CA	0.83935921
49	OXSR1	0.82298347
50	ADRBK1	0.80405452
51	AURKA	0.79877260
52	INSRR	0.79322128
53	NTRK2	0.79222597
54	LIMK1	0.77659119
55	GRK6	0.76758640
56	ILK	0.73773129
57	FES	0.72945004
58	PIM2	0.72170617
59	PRKCD	0.72069815
60	BRAF	0.71458204
61	AKT3	0.69980194
62	CAMK1	0.69226943
63	RPS6KA5	0.68586953
64	BTK	0.66687260
65	MAP3K12	0.65241412
66	DAPK1	0.60065238
67	SYK	0.58625875
68	OBSCN	0.57145594
69	TESK1	0.55966732
70	CSNK2A2	0.55770223
71	MAP2K7	0.55724720
72	PRKACA	0.55314864
73	PIM1	0.53333482
74	LCK	0.52902899
75	PRKCE	0.52849721
76	EPHB2	0.52034754
77	KIT	0.51729740
78	CSNK2A1	0.48849298
79	MAPK13	0.47437322
80	PRKCZ	0.46099981
81	GRK7	0.45999394
82	EPHA4	0.44728681
83	PRKCA	0.44471018
84	CSNK1G3	0.42055181
85	CDC7	0.41536432
86	AURKB	0.41220149
87	IRAK4	0.40046477
88	RPS6KA6	0.38631489
89	GRK5	0.36737200
90	MAP2K2	0.36616359
91	CAMK2A	0.36362409
92	DAPK2	0.34096967
93	PLK1	0.32446370
94	MAPKAPK5	0.32158987
95	PKN1	0.32010712
96	CASK	0.30770962
97	ABL2	0.29990849
98	BCR	0.29602763
99	ATR	0.28439441
100	PRKCB	0.27848627

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.95623868
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.26835763
3	Parkinsons disease_Homo sapiens_hsa05012	3.68194731
4	Proteasome_Homo sapiens_hsa03050	2.68019737
5	Primary immunodeficiency_Homo sapiens_hsa05340	2.60910750
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.53318812
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.39814025
8	Alzheimers disease_Homo sapiens_hsa05010	2.36906727
9	Huntingtons disease_Homo sapiens_hsa05016	2.35289354
10	RNA polymerase_Homo sapiens_hsa03020	2.24013500
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.23667144
12	Sulfur relay system_Homo sapiens_hsa04122	1.81752892
13	RNA degradation_Homo sapiens_hsa03018	1.68726717
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.67239067
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.61732718
16	Homologous recombination_Homo sapiens_hsa03440	1.55046013
17	Protein export_Homo sapiens_hsa03060	1.53198477
18	Phototransduction_Homo sapiens_hsa04744	1.51500385
19	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.50899235
20	One carbon pool by folate_Homo sapiens_hsa00670	1.49186242
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.45902874
22	Pyrimidine metabolism_Homo sapiens_hsa00240	1.37325697
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.35753187
24	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.32761826
25	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.30220170
26	Graft-versus-host disease_Homo sapiens_hsa05332	1.27081537
27	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.20108338
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.17078225
29	Allograft rejection_Homo sapiens_hsa05330	1.15301978
30	Asthma_Homo sapiens_hsa05310	1.13319392
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.10769656
32	Olfactory transduction_Homo sapiens_hsa04740	1.07565844
33	Fanconi anemia pathway_Homo sapiens_hsa03460	1.07521813
34	Peroxisome_Homo sapiens_hsa04146	1.07227490
35	Basal transcription factors_Homo sapiens_hsa03022	1.03624756
36	Tyrosine metabolism_Homo sapiens_hsa00350	1.02227491
37	DNA replication_Homo sapiens_hsa03030	0.98812249
38	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.98572555
39	Caffeine metabolism_Homo sapiens_hsa00232	0.97741765
40	Antigen processing and presentation_Homo sapiens_hsa04612	0.94964292
41	Purine metabolism_Homo sapiens_hsa00230	0.94836190
42	Tryptophan metabolism_Homo sapiens_hsa00380	0.94514820
43	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.92189318
44	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.91330154
45	Base excision repair_Homo sapiens_hsa03410	0.90183483
46	Nicotine addiction_Homo sapiens_hsa05033	0.89915463
47	Type I diabetes mellitus_Homo sapiens_hsa04940	0.88965612
48	Butanoate metabolism_Homo sapiens_hsa00650	0.85371303
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.82262313
50	Nucleotide excision repair_Homo sapiens_hsa03420	0.80438519
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.79077663
52	Mismatch repair_Homo sapiens_hsa03430	0.76369204
53	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.74974079
54	Folate biosynthesis_Homo sapiens_hsa00790	0.74932461
55	RNA transport_Homo sapiens_hsa03013	0.73364428
56	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.72653888
57	Fat digestion and absorption_Homo sapiens_hsa04975	0.71367854
58	Propanoate metabolism_Homo sapiens_hsa00640	0.69976547
59	Spliceosome_Homo sapiens_hsa03040	0.69972730
60	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.69823308
61	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.69720696
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.67908880
63	Retinol metabolism_Homo sapiens_hsa00830	0.66213455
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.65868146
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.65862685
66	Metabolic pathways_Homo sapiens_hsa01100	0.65700094
67	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.64967747
68	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.64264000
69	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.61233336
70	Taste transduction_Homo sapiens_hsa04742	0.59962721
71	Morphine addiction_Homo sapiens_hsa05032	0.59669351
72	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.57472671
73	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.54361151
74	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.54254523
75	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.51574093
76	Rheumatoid arthritis_Homo sapiens_hsa05323	0.46529098
77	Ether lipid metabolism_Homo sapiens_hsa00565	0.46003779
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.43474993
79	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.42528385
80	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.40650503
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40337406
82	Regulation of autophagy_Homo sapiens_hsa04140	0.39762989
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.38675699
84	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.38436787
85	Malaria_Homo sapiens_hsa05144	0.35541796
86	Pyruvate metabolism_Homo sapiens_hsa00620	0.33958610
87	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.33869958
88	Fatty acid degradation_Homo sapiens_hsa00071	0.33794136
89	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.33409723
90	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.33041734
91	Steroid biosynthesis_Homo sapiens_hsa00100	0.31371529
92	beta-Alanine metabolism_Homo sapiens_hsa00410	0.29557084
93	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.28314006
94	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.28259839
95	Glutathione metabolism_Homo sapiens_hsa00480	0.27760924
96	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.25244983
97	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.20437550
98	Serotonergic synapse_Homo sapiens_hsa04726	0.19794010
99	Collecting duct acid secretion_Homo sapiens_hsa04966	0.19156827
100	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.18667247

RPL27AP5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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