RPL27AP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)8.69299071
2translational termination (GO:0006415)8.28299093
3ribosomal small subunit biogenesis (GO:0042274)8.01612656
4maturation of SSU-rRNA (GO:0030490)7.77599279
5ribosomal small subunit assembly (GO:0000028)6.96370267
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.94441613
7cotranslational protein targeting to membrane (GO:0006613)6.87785872
8protein targeting to ER (GO:0045047)6.81803635
9translational elongation (GO:0006414)6.78161964
10establishment of protein localization to endoplasmic reticulum (GO:0072599)6.52730022
11protein localization to endoplasmic reticulum (GO:0070972)6.38378625
12cellular protein complex disassembly (GO:0043624)6.29710212
13viral life cycle (GO:0019058)6.24546263
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.06894406
15protein complex disassembly (GO:0043241)5.47139338
16behavioral response to nicotine (GO:0035095)5.46268049
17translational initiation (GO:0006413)5.23962705
18macromolecular complex disassembly (GO:0032984)5.18520683
19chaperone-mediated protein transport (GO:0072321)5.13598563
20ribosomal large subunit biogenesis (GO:0042273)4.73705393
21protein targeting to membrane (GO:0006612)4.62395681
22pattern specification involved in kidney development (GO:0061004)4.61660540
23substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.44948787
24substrate-independent telencephalic tangential migration (GO:0021826)4.44948787
25nuclear-transcribed mRNA catabolic process (GO:0000956)4.23838022
26establishment of protein localization to mitochondrial membrane (GO:0090151)4.21762220
27tongue development (GO:0043586)4.17259108
28mRNA catabolic process (GO:0006402)4.02557942
29translation (GO:0006412)3.99422544
30nonmotile primary cilium assembly (GO:0035058)3.95781872
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.74824940
32cell proliferation in forebrain (GO:0021846)3.74712665
33neuron fate determination (GO:0048664)3.73127733
34cardiovascular system development (GO:0072358)3.64948466
35RNA catabolic process (GO:0006401)3.57512465
36ribonucleoprotein complex biogenesis (GO:0022613)3.57049292
37protein neddylation (GO:0045116)3.53580163
38ATP synthesis coupled proton transport (GO:0015986)3.50203983
39energy coupled proton transport, down electrochemical gradient (GO:0015985)3.50203983
40water-soluble vitamin biosynthetic process (GO:0042364)3.50097825
41mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40683229
42mitochondrial respiratory chain complex I assembly (GO:0032981)3.40683229
43NADH dehydrogenase complex assembly (GO:0010257)3.40683229
44segment specification (GO:0007379)3.40577501
45cellular component biogenesis (GO:0044085)3.34008824
46GTP biosynthetic process (GO:0006183)3.31323360
47mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.24558049
48pyrimidine nucleobase catabolic process (GO:0006208)3.19836228
49central nervous system myelination (GO:0022010)3.19405136
50axon ensheathment in central nervous system (GO:0032291)3.19405136
51protein complex biogenesis (GO:0070271)3.16047088
52establishment of protein localization to membrane (GO:0090150)3.14802864
53auditory receptor cell differentiation (GO:0042491)3.12280189
54pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.10534157
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.06735542
56kinetochore assembly (GO:0051382)2.99956800
57UTP biosynthetic process (GO:0006228)2.97981717
58protein targeting (GO:0006605)2.97142494
59hypothalamus development (GO:0021854)2.93512023
60establishment of protein localization to organelle (GO:0072594)2.88733494
61radial glial cell differentiation (GO:0060019)2.86242742
62L-serine metabolic process (GO:0006563)2.77802392
63UTP metabolic process (GO:0046051)2.77707417
64kinetochore organization (GO:0051383)2.77509393
65nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.77379933
66pyrimidine nucleotide catabolic process (GO:0006244)2.77161671
67somite development (GO:0061053)2.76182856
68mitochondrial respiratory chain complex assembly (GO:0033108)2.76042180
69mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.75890208
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.73409156
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.73409156
72protein polyglutamylation (GO:0018095)2.73377712
73ubiquinone biosynthetic process (GO:0006744)2.71789346
74spinal cord association neuron differentiation (GO:0021527)2.68977424
75exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.68377898
76olfactory bulb development (GO:0021772)2.66345400
77epithelial cilium movement (GO:0003351)2.65256211
78positive regulation of fatty acid transport (GO:2000193)2.62206246
79negative regulation of granulocyte differentiation (GO:0030853)2.61965641
80positive regulation of icosanoid secretion (GO:0032305)2.60879614
81negative regulation of response to food (GO:0032096)2.60068412
82negative regulation of appetite (GO:0032099)2.60068412
83Sertoli cell development (GO:0060009)2.60042729
84positive regulation of T cell apoptotic process (GO:0070234)2.59492397
85resolution of meiotic recombination intermediates (GO:0000712)2.59432989
86cerebral cortex radially oriented cell migration (GO:0021799)2.59161781
87CTP metabolic process (GO:0046036)2.56919096
88CTP biosynthetic process (GO:0006241)2.56919096
89replication fork processing (GO:0031297)2.56495166
90negative regulation of oligodendrocyte differentiation (GO:0048715)2.55261448
91rRNA processing (GO:0006364)2.54023062
92respiratory electron transport chain (GO:0022904)2.53989132
93electron transport chain (GO:0022900)2.53713381
94negative regulation of astrocyte differentiation (GO:0048712)2.52527074
95regulation of immunoglobulin secretion (GO:0051023)2.52153684
96rRNA metabolic process (GO:0016072)2.51114149
97neuronal stem cell maintenance (GO:0097150)2.50656481
98negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.49871937
99ubiquinone metabolic process (GO:0006743)2.48935366
100regulation of isotype switching to IgG isotypes (GO:0048302)2.47884250

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.77203857
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.81506309
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.07086212
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.77698859
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.44246503
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.22044607
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.19692770
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.11816926
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.06365510
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06284153
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03628022
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.03167694
13EZH2_27304074_Chip-Seq_ESCs_Mouse1.99693083
14EST1_17652178_ChIP-ChIP_JURKAT_Human1.96720472
15MYC_18555785_ChIP-Seq_MESCs_Mouse1.95986179
16EZH2_27294783_Chip-Seq_ESCs_Mouse1.95955871
17CBX2_27304074_Chip-Seq_ESCs_Mouse1.92652171
18SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77216213
19IRF1_19129219_ChIP-ChIP_H3396_Human1.76734209
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73820147
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71198782
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70462533
23CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.69390991
24TTF2_22483619_ChIP-Seq_HELA_Human1.66636682
25KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.65740441
26XRN2_22483619_ChIP-Seq_HELA_Human1.65691120
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.65517077
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61995810
29REST_21632747_ChIP-Seq_MESCs_Mouse1.60597902
30MYC_18940864_ChIP-ChIP_HL60_Human1.59765329
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.57637818
32GATA1_26923725_Chip-Seq_HPCs_Mouse1.57245655
33SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.55574211
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53784502
35CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.45635614
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.43107160
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40712582
38RNF2_27304074_Chip-Seq_NSC_Mouse1.39060034
39ERA_21632823_ChIP-Seq_H3396_Human1.37335592
40VDR_22108803_ChIP-Seq_LS180_Human1.37003687
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36133829
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.34137792
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.33837911
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.33837911
45TP53_20018659_ChIP-ChIP_R1E_Mouse1.33711865
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33209901
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.31958871
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31430927
49GABP_19822575_ChIP-Seq_HepG2_Human1.29906701
50ZNF274_21170338_ChIP-Seq_K562_Hela1.28995389
51RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.27630322
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22374214
53SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.22118201
54ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21575516
55REST_18959480_ChIP-ChIP_MESCs_Mouse1.21167946
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.19134347
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18454384
58CTCF_27219007_Chip-Seq_Bcells_Human1.18380740
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16730182
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16301967
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15817570
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14609948
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12073017
64CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11969227
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11212624
66CTCF_18555785_ChIP-Seq_MESCs_Mouse1.10862249
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10460960
68TAF2_19829295_ChIP-Seq_ESCs_Human1.10388659
69EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09728965
70OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09459301
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08628885
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07193609
73NANOG_20526341_ChIP-Seq_ESCs_Human1.07154362
74TP53_22573176_ChIP-Seq_HFKS_Human1.07095556
75GATA3_21878914_ChIP-Seq_MCF-7_Human1.06604406
76CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04980953
77RING1B_27294783_Chip-Seq_ESCs_Mouse1.04838304
78TDRD3_21172665_ChIP-Seq_MCF-7_Human1.04132409
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.03914241
80FOXP3_21729870_ChIP-Seq_TREG_Human1.02733354
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02634634
82SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02483136
83CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02137020
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.00334958
85CTCF_20526341_ChIP-Seq_ESCs_Human0.99246757
86YY1_22570637_ChIP-Seq_MALME-3M_Human0.98672578
87FOXP1_21924763_ChIP-Seq_HESCs_Human0.98662284
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97813382
89SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96675414
90E2F1_17053090_ChIP-ChIP_MCF-7_Human0.95156452
91P53_21459846_ChIP-Seq_SAOS-2_Human0.94708558
92P68_20966046_ChIP-Seq_HELA_Human0.94565472
93SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94428957
94RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94273772
95VDR_23849224_ChIP-Seq_CD4+_Human0.93335308
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93315747
97RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92035907
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90838883
99SA1_27219007_Chip-Seq_Bcells_Human0.89057008
100SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.86927133

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.06090842
2MP0006292_abnormal_olfactory_placode5.00915368
3MP0003787_abnormal_imprinting3.61103137
4MP0003122_maternal_imprinting3.24047101
5MP0004142_abnormal_muscle_tone2.73760017
6MP0008789_abnormal_olfactory_epithelium2.72411493
7MP0002653_abnormal_ependyma_morphology2.55729315
8MP0003123_paternal_imprinting2.43216430
9MP0005377_hearing/vestibular/ear_phenot2.38694296
10MP0003878_abnormal_ear_physiology2.38694296
11MP0003121_genomic_imprinting2.31806991
12MP0001293_anophthalmia2.30128911
13MP0005499_abnormal_olfactory_system2.24321990
14MP0005394_taste/olfaction_phenotype2.24321990
15MP0002163_abnormal_gland_morphology2.09250244
16MP0000778_abnormal_nervous_system2.09130113
17MP0006276_abnormal_autonomic_nervous2.02853874
18MP0008877_abnormal_DNA_methylation1.88806695
19MP0010030_abnormal_orbit_morphology1.81614166
20MP0001485_abnormal_pinna_reflex1.80985569
21MP0000049_abnormal_middle_ear1.77684783
22MP0002102_abnormal_ear_morphology1.77103816
23MP0003136_yellow_coat_color1.70974760
24MP0002938_white_spotting1.67226846
25MP0000631_abnormal_neuroendocrine_gland1.66021093
26MP0001968_abnormal_touch/_nociception1.62498652
27MP0001529_abnormal_vocalization1.61927657
28MP0004885_abnormal_endolymph1.61312922
29MP0004742_abnormal_vestibular_system1.58718355
30MP0003646_muscle_fatigue1.47398384
31MP0002638_abnormal_pupillary_reflex1.41423892
32MP0001984_abnormal_olfaction1.34188666
33MP0004133_heterotaxia1.33041244
34MP0005195_abnormal_posterior_eye1.30352331
35MP0001440_abnormal_grooming_behavior1.30201220
36MP0002557_abnormal_social/conspecific_i1.27337400
37MP0002736_abnormal_nociception_after1.25703867
38MP0008875_abnormal_xenobiotic_pharmacok1.25583503
39MP0005551_abnormal_eye_electrophysiolog1.24277313
40MP0002095_abnormal_skin_pigmentation1.23732529
41MP0002272_abnormal_nervous_system1.23309925
42MP0002733_abnormal_thermal_nociception1.20724316
43MP0002234_abnormal_pharynx_morphology1.18970878
44MP0003942_abnormal_urinary_system1.17796601
45MP0008872_abnormal_physiological_respon1.17645082
46MP0000026_abnormal_inner_ear1.17388963
47MP0000955_abnormal_spinal_cord1.16994371
48MP0009745_abnormal_behavioral_response1.14434013
49MP0001970_abnormal_pain_threshold1.11195952
50MP0001286_abnormal_eye_development1.11077883
51MP0001873_stomach_inflammation1.10675417
52MP0003879_abnormal_hair_cell1.09468881
53MP0001502_abnormal_circadian_rhythm1.09424589
54MP0005423_abnormal_somatic_nervous1.08721263
55MP0002063_abnormal_learning/memory/cond1.08170911
56MP0003880_abnormal_central_pattern1.07330994
57MP0003186_abnormal_redox_activity1.07276364
58MP0002752_abnormal_somatic_nervous1.05276565
59MP0009053_abnormal_anal_canal1.02864557
60MP0001963_abnormal_hearing_physiology1.00704830
61MP0001905_abnormal_dopamine_level1.00510408
62MP0003938_abnormal_ear_development1.00101719
63MP0003011_delayed_dark_adaptation0.99501060
64MP0003937_abnormal_limbs/digits/tail_de0.98611911
65MP0004145_abnormal_muscle_electrophysio0.96712902
66MP0002734_abnormal_mechanical_nocicepti0.95850464
67MP0005379_endocrine/exocrine_gland_phen0.94847990
68MP0002572_abnormal_emotion/affect_behav0.94524895
69MP0008775_abnormal_heart_ventricle0.94013856
70MP0006072_abnormal_retinal_apoptosis0.93791218
71MP0005389_reproductive_system_phenotype0.92668625
72MP0000566_synostosis0.92662529
73MP0002233_abnormal_nose_morphology0.92337415
74MP0002184_abnormal_innervation0.91888556
75MP0002160_abnormal_reproductive_system0.91544984
76MP0002067_abnormal_sensory_capabilities0.90353595
77MP0000427_abnormal_hair_cycle0.90304464
78MP0003635_abnormal_synaptic_transmissio0.87481191
79MP0002152_abnormal_brain_morphology0.86962069
80MP0002249_abnormal_larynx_morphology0.84094046
81MP0002876_abnormal_thyroid_physiology0.82879599
82MP0003861_abnormal_nervous_system0.82594082
83MP0002064_seizures0.82495608
84MP0002116_abnormal_craniofacial_bone0.81739518
85MP0009250_abnormal_appendicular_skeleto0.81365106
86MP0002882_abnormal_neuron_morphology0.79606214
87MP0004859_abnormal_synaptic_plasticity0.78276218
88MP0001919_abnormal_reproductive_system0.78084416
89MP0009046_muscle_twitch0.77673204
90MP0001486_abnormal_startle_reflex0.76842533
91MP0005408_hypopigmentation0.76016896
92MP0003755_abnormal_palate_morphology0.74881706
93MP0001663_abnormal_digestive_system0.74759024
94MP0004147_increased_porphyrin_level0.74020446
95MP0002837_dystrophic_cardiac_calcinosis0.73901921
96MP0001348_abnormal_lacrimal_gland0.73822281
97MP0001324_abnormal_eye_pigmentation0.73376829
98MP0002735_abnormal_chemical_nociception0.71805411
99MP0005174_abnormal_tail_pigmentation0.70893038
100MP0002697_abnormal_eye_size0.70778124

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.66714516
2Abnormality of cells of the erythroid lineage (HP:0012130)5.01257014
3Macrocytic anemia (HP:0001972)4.23679893
4Molar tooth sign on MRI (HP:0002419)4.07043846
5Abnormality of midbrain morphology (HP:0002418)4.07043846
6Septo-optic dysplasia (HP:0100842)3.96207660
7Pancreatic fibrosis (HP:0100732)3.96171195
8Acute necrotizing encephalopathy (HP:0006965)3.76062739
9Pallor (HP:0000980)3.55603877
10Acute encephalopathy (HP:0006846)3.40841579
11Abnormal number of erythroid precursors (HP:0012131)3.40387446
12Stenosis of the external auditory canal (HP:0000402)3.26701601
13Rib fusion (HP:0000902)3.19977907
14Abnormal mitochondria in muscle tissue (HP:0008316)3.17614059
15Pancreatic cysts (HP:0001737)3.16213770
16Aplasia/Hypoplasia of the sacrum (HP:0008517)3.05826592
17Chronic hepatic failure (HP:0100626)3.04913300
18Absent thumb (HP:0009777)2.96162560
19Abnormality of the labia minora (HP:0012880)2.95882329
20True hermaphroditism (HP:0010459)2.95291627
21Progressive macrocephaly (HP:0004481)2.94347692
22Nephronophthisis (HP:0000090)2.92884258
23Absent rod-and cone-mediated responses on ERG (HP:0007688)2.83411615
24Mitochondrial inheritance (HP:0001427)2.82019292
25Medial flaring of the eyebrow (HP:0010747)2.75222077
26Pendular nystagmus (HP:0012043)2.71282384
27Colon cancer (HP:0003003)2.70598805
28Anencephaly (HP:0002323)2.69368730
29Abnormality of DNA repair (HP:0003254)2.65359046
30Adrenal hypoplasia (HP:0000835)2.65348493
31Depressed nasal ridge (HP:0000457)2.59317849
32Cystic liver disease (HP:0006706)2.55716005
33Hyperglycinemia (HP:0002154)2.50377120
34Abnormal rod and cone electroretinograms (HP:0008323)2.46164178
35Type II lissencephaly (HP:0007260)2.44787736
36Abnormality of the renal medulla (HP:0100957)2.43557560
37Maternal diabetes (HP:0009800)2.43516898
38Hypoplasia of the ulna (HP:0003022)2.43032639
39Increased CSF lactate (HP:0002490)2.42303402
40Hyperthyroidism (HP:0000836)2.41754071
41Growth hormone deficiency (HP:0000824)2.41164636
42Anophthalmia (HP:0000528)2.38451908
43Aplasia/Hypoplasia of the spleen (HP:0010451)2.37760896
44Sclerocornea (HP:0000647)2.36394098
45Oligodactyly (hands) (HP:0001180)2.36302979
46Abnormal hemoglobin (HP:0011902)2.32186774
47Oligodactyly (HP:0012165)2.31950694
48Cerebral edema (HP:0002181)2.31568113
49Myokymia (HP:0002411)2.28294725
50Asplenia (HP:0001746)2.22387548
51Optic nerve hypoplasia (HP:0000609)2.20130160
52Optic disc pallor (HP:0000543)2.19546326
53Increased hepatocellular lipid droplets (HP:0006565)2.17609252
54Gait imbalance (HP:0002141)2.15702870
55Horseshoe kidney (HP:0000085)2.14688727
56Lipid accumulation in hepatocytes (HP:0006561)2.08355920
57Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.07557773
58Absent septum pellucidum (HP:0001331)2.06794543
59Aplasia/Hypoplasia of the tongue (HP:0010295)2.05500185
60Aplasia/Hypoplasia of the ulna (HP:0006495)2.05226229
61Postaxial foot polydactyly (HP:0001830)2.02584868
62Hypoplasia of the radius (HP:0002984)2.01900142
63Congenital primary aphakia (HP:0007707)2.01793195
64Agitation (HP:0000713)2.01300868
65Forearm undergrowth (HP:0009821)1.98221144
66Tubular atrophy (HP:0000092)1.96036807
67Supernumerary spleens (HP:0009799)1.95418375
68Diastasis recti (HP:0001540)1.93722360
69Deep palmar crease (HP:0006191)1.89209392
70Polydipsia (HP:0001959)1.87768673
71Abnormal drinking behavior (HP:0030082)1.87768673
72Abnormal hair whorl (HP:0010721)1.85849566
73Hepatocellular necrosis (HP:0001404)1.85564982
74Congenital hepatic fibrosis (HP:0002612)1.85254119
75Polyuria (HP:0000103)1.84741498
76Ectopic kidney (HP:0000086)1.83839929
77Bile duct proliferation (HP:0001408)1.83660569
78Abnormal biliary tract physiology (HP:0012439)1.83660569
79Holoprosencephaly (HP:0001360)1.83582883
80Congenital stationary night blindness (HP:0007642)1.80617108
81Lissencephaly (HP:0001339)1.79491056
82Abnormality of the aortic arch (HP:0012303)1.78593287
83Nephrogenic diabetes insipidus (HP:0009806)1.77794761
84Optic nerve coloboma (HP:0000588)1.77412533
85Poor coordination (HP:0002370)1.76846870
86Abnormal number of incisors (HP:0011064)1.76803423
87Postaxial hand polydactyly (HP:0001162)1.76118942
88Abnormality of reticulocytes (HP:0004312)1.75911375
89Partial duplication of thumb phalanx (HP:0009944)1.74392792
90Neoplasm of the adrenal cortex (HP:0100641)1.73310615
91Annular pancreas (HP:0001734)1.71123317
92Abnormality of cochlea (HP:0000375)1.68642495
93Male pseudohermaphroditism (HP:0000037)1.68467337
94Absent/shortened dynein arms (HP:0200106)1.68349884
95Dynein arm defect of respiratory motile cilia (HP:0012255)1.68349884
96Dandy-Walker malformation (HP:0001305)1.68018964
97Increased corneal curvature (HP:0100692)1.67549779
98Keratoconus (HP:0000563)1.67549779
99Abnormality of the diencephalon (HP:0010662)1.67542216
100Cerebellar dysplasia (HP:0007033)1.67388029

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK43.81902643
2BCKDK3.02980539
3DYRK23.01063811
4CDK192.74257690
5MAP3K112.50179055
6PIK3CA2.30272015
7GRK12.22639138
8ADRBK22.15017250
9LRRK22.09380942
10CASK2.08496302
11TYRO32.01302899
12EPHB21.94006582
13TIE11.83735433
14NUAK11.80667438
15STK391.77929471
16CAMK1D1.74604751
17NME11.71276249
18TLK11.69697664
19EPHA41.65477637
20PINK11.59812701
21CDC71.52599520
22ZAK1.42975499
23PRKCG1.39948631
24STK161.39727208
25BRAF1.38234036
26FRK1.33829425
27NTRK21.30297066
28TXK1.27952851
29STK111.20488146
30MAP2K71.15075994
31DYRK1B1.13494969
32CAMK11.13371106
33TNIK1.13008197
34AURKA1.09029552
35PRKCH1.08486485
36CAMK1G1.06835606
37BMPR1B1.05437287
38MAP4K21.04615800
39DAPK31.04444626
40OXSR11.01093290
41LIMK10.97949033
42MKNK20.97592792
43WNK30.97321381
44MAP3K40.96966634
45CDC42BPA0.96796162
46MAP2K60.96343456
47PRKCQ0.85748265
48MARK10.85565175
49CAMKK20.83338056
50WNK10.82627479
51SGK4940.82476104
52SGK2230.82476104
53RPS6KA60.82016564
54PAK30.81715114
55ADRBK10.80282292
56PRKD30.79403659
57AURKB0.78071936
58PRKCZ0.74500268
59ARAF0.73901956
60PLK10.73228215
61MOS0.71918785
62MAP2K20.71878674
63VRK20.71708818
64MAPK150.70538745
65NEK10.70337974
66CAMK40.70140611
67MAPK130.69134963
68DMPK0.68570915
69CDK80.66256247
70PDK20.66038869
71PRKCI0.65441257
72PHKG20.64916807
73PHKG10.64916807
74CSNK2A20.64602262
75PIM20.63533121
76CSNK1E0.62953640
77RPS6KL10.62578852
78RPS6KC10.62578852
79MAP3K90.61981577
80PLK40.60291416
81PRKACA0.59733774
82PAK60.59193038
83TAF10.59175051
84PBK0.57989639
85CAMKK10.56848720
86PASK0.54481683
87NTRK30.53834535
88SGK10.53493750
89MAP2K40.52805792
90CSNK1G20.52774502
91NME20.52086755
92ABL20.50845744
93INSRR0.50761781
94CSNK1G30.46165412
95TGFBR10.43609304
96PRKCD0.42606955
97CAMK2A0.38673656
98PRKCA0.38439793
99CSNK2A10.37014006
100CAMK2D0.35694718

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.35277935
2Oxidative phosphorylation_Homo sapiens_hsa001903.61147010
3Parkinsons disease_Homo sapiens_hsa050122.95638789
4Sulfur relay system_Homo sapiens_hsa041222.79143497
5RNA polymerase_Homo sapiens_hsa030202.58194428
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.54981434
7Cardiac muscle contraction_Homo sapiens_hsa042602.43640782
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.42513080
9Huntingtons disease_Homo sapiens_hsa050162.25900638
10Protein export_Homo sapiens_hsa030602.24102820
11Alzheimers disease_Homo sapiens_hsa050102.02226799
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.99001021
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83889366
14Linoleic acid metabolism_Homo sapiens_hsa005911.83716508
15Fanconi anemia pathway_Homo sapiens_hsa034601.76066846
16RNA degradation_Homo sapiens_hsa030181.73114070
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.66128670
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60041126
19Basal transcription factors_Homo sapiens_hsa030221.55540068
20Steroid biosynthesis_Homo sapiens_hsa001001.43326754
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41687974
22Proteasome_Homo sapiens_hsa030501.36943506
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.34727571
24Phototransduction_Homo sapiens_hsa047441.32585291
25One carbon pool by folate_Homo sapiens_hsa006701.32140437
26Pyrimidine metabolism_Homo sapiens_hsa002401.26769789
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26329140
28Nicotine addiction_Homo sapiens_hsa050331.25245296
29Homologous recombination_Homo sapiens_hsa034401.24976567
30Basal cell carcinoma_Homo sapiens_hsa052171.22062938
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21888155
32Butanoate metabolism_Homo sapiens_hsa006501.17933267
33Tryptophan metabolism_Homo sapiens_hsa003801.16006159
34Vitamin B6 metabolism_Homo sapiens_hsa007501.08785237
35Folate biosynthesis_Homo sapiens_hsa007901.05449882
36Peroxisome_Homo sapiens_hsa041461.05052581
37Caffeine metabolism_Homo sapiens_hsa002321.04120659
38Nucleotide excision repair_Homo sapiens_hsa034201.04048403
39Propanoate metabolism_Homo sapiens_hsa006401.01379602
40Fat digestion and absorption_Homo sapiens_hsa049751.00840332
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99177680
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96465180
43Asthma_Homo sapiens_hsa053100.95984277
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94143009
45Hedgehog signaling pathway_Homo sapiens_hsa043400.90567183
46Arachidonic acid metabolism_Homo sapiens_hsa005900.90208230
47Notch signaling pathway_Homo sapiens_hsa043300.89635992
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84873832
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.84183026
50Mismatch repair_Homo sapiens_hsa034300.83701693
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80483430
52Collecting duct acid secretion_Homo sapiens_hsa049660.78190203
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.75957861
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75639760
55Ether lipid metabolism_Homo sapiens_hsa005650.68561433
56Metabolic pathways_Homo sapiens_hsa011000.68066956
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.67252109
58Purine metabolism_Homo sapiens_hsa002300.66367829
59Nitrogen metabolism_Homo sapiens_hsa009100.63335247
60Morphine addiction_Homo sapiens_hsa050320.60523152
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60198010
62Hippo signaling pathway_Homo sapiens_hsa043900.58705003
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.58204212
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.57265089
65Arginine and proline metabolism_Homo sapiens_hsa003300.55273340
66DNA replication_Homo sapiens_hsa030300.54971708
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53817671
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53466624
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51758631
70RNA transport_Homo sapiens_hsa030130.50920017
71Axon guidance_Homo sapiens_hsa043600.50029246
72Base excision repair_Homo sapiens_hsa034100.48980078
73Chemical carcinogenesis_Homo sapiens_hsa052040.48759187
74Retinol metabolism_Homo sapiens_hsa008300.43164253
75Pyruvate metabolism_Homo sapiens_hsa006200.42366921
76Ovarian steroidogenesis_Homo sapiens_hsa049130.40753134
77Fatty acid degradation_Homo sapiens_hsa000710.39194746
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38901864
79Olfactory transduction_Homo sapiens_hsa047400.38209992
80Glutathione metabolism_Homo sapiens_hsa004800.37338626
81Glutamatergic synapse_Homo sapiens_hsa047240.37098273
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36462240
83Glycerolipid metabolism_Homo sapiens_hsa005610.36134767
84Tyrosine metabolism_Homo sapiens_hsa003500.35837950
85Regulation of autophagy_Homo sapiens_hsa041400.34971902
86Taste transduction_Homo sapiens_hsa047420.34488790
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.33852176
88beta-Alanine metabolism_Homo sapiens_hsa004100.32779980
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31427814
90Insulin secretion_Homo sapiens_hsa049110.30720994
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30373576
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29766618
93Wnt signaling pathway_Homo sapiens_hsa043100.25330683
94Serotonergic synapse_Homo sapiens_hsa047260.24906110
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.24464575
96Allograft rejection_Homo sapiens_hsa053300.23767397
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23403609
98Phenylalanine metabolism_Homo sapiens_hsa003600.21971229
99GABAergic synapse_Homo sapiens_hsa047270.21048996
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20544061

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