RPL28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)9.20595329
2ribosomal small subunit assembly (GO:0000028)8.91935669
3* translational elongation (GO:0006414)8.52493506
4* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)8.37803267
5* protein targeting to ER (GO:0045047)8.23002098
6* cotranslational protein targeting to membrane (GO:0006613)8.21155016
7* establishment of protein localization to endoplasmic reticulum (GO:0072599)7.86713118
8* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)7.84874808
9* cellular protein complex disassembly (GO:0043624)7.83925315
10* viral life cycle (GO:0019058)7.79082917
11* protein localization to endoplasmic reticulum (GO:0070972)7.63232550
12maturation of SSU-rRNA (GO:0030490)7.46899196
13* translational initiation (GO:0006413)7.33979959
14* protein complex disassembly (GO:0043241)6.94777665
15ribosomal large subunit biogenesis (GO:0042273)6.91234717
16* macromolecular complex disassembly (GO:0032984)6.47155680
17* protein targeting to membrane (GO:0006612)5.47720046
18* nuclear-transcribed mRNA catabolic process (GO:0000956)5.45246254
19* mRNA catabolic process (GO:0006402)5.18801438
20* translation (GO:0006412)4.97830467
21* RNA catabolic process (GO:0006401)4.87127391
22ribonucleoprotein complex biogenesis (GO:0022613)4.82083713
23negative regulation of erythrocyte differentiation (GO:0045647)4.49700978
24ncRNA 3-end processing (GO:0043628)4.13267421
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.04295080
26modulation by virus of host process (GO:0019054)4.01813587
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.89476249
28antigen processing and presentation of endogenous antigen (GO:0019883)3.82993175
29formation of translation preinitiation complex (GO:0001731)3.78089290
30rRNA processing (GO:0006364)3.74569462
31modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.74160443
32positive regulation by organism of defense response of other organism involved in symbiotic interact3.74160443
33modulation by symbiont of host immune response (GO:0052553)3.74160443
34positive regulation by symbiont of host defense response (GO:0052509)3.74160443
35modulation by symbiont of host defense response (GO:0052031)3.74160443
36modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.74160443
37positive regulation of gamma-delta T cell activation (GO:0046645)3.69793640
38positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.67457226
39* establishment of protein localization to membrane (GO:0090150)3.64411395
40rRNA metabolic process (GO:0016072)3.61065193
41modulation by symbiont of host cellular process (GO:0044068)3.60633035
42DNA strand elongation involved in DNA replication (GO:0006271)3.55413680
43cellular component biogenesis (GO:0044085)3.49719708
44positive thymic T cell selection (GO:0045059)3.46402948
45DNA unwinding involved in DNA replication (GO:0006268)3.45982284
46DNA deamination (GO:0045006)3.43960343
47thymic T cell selection (GO:0045061)3.43160511
48telomere maintenance via semi-conservative replication (GO:0032201)3.42909923
49negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.35075671
50negative regulation of cell killing (GO:0031342)3.35075671
51DNA strand elongation (GO:0022616)3.34322295
52negative regulation of RNA splicing (GO:0033119)3.33885275
53* establishment of protein localization to organelle (GO:0072594)3.29045632
54* protein targeting (GO:0006605)3.28872931
55spliceosomal complex assembly (GO:0000245)3.20143720
56negative regulation of phagocytosis (GO:0050765)3.18714277
57spliceosomal snRNP assembly (GO:0000387)3.14775310
58leukocyte aggregation (GO:0070486)3.13655911
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.10490567
60tolerance induction (GO:0002507)3.08802461
61DNA replication checkpoint (GO:0000076)3.08302470
62NIK/NF-kappaB signaling (GO:0038061)3.03670293
63folic acid-containing compound biosynthetic process (GO:0009396)2.97911143
64* cellular component disassembly (GO:0022411)2.94188626
65detection of bacterium (GO:0016045)2.93772972
66protein localization to kinetochore (GO:0034501)2.92317721
67DNA replication initiation (GO:0006270)2.89829536
68positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.88793880
69telomere maintenance via recombination (GO:0000722)2.85905525
70T cell selection (GO:0045058)2.80130012
71mitotic recombination (GO:0006312)2.78842580
72mannose metabolic process (GO:0006013)2.78257758
73apoptotic process involved in morphogenesis (GO:0060561)2.77440089
74regulation of superoxide anion generation (GO:0032928)2.76282144
75positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.75179117
76negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.73965399
77mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.73947842
78response to peptidoglycan (GO:0032494)2.73767002
79negative thymic T cell selection (GO:0045060)2.72943641
80nucleotide-excision repair, DNA gap filling (GO:0006297)2.71936365
81telomere maintenance via telomere lengthening (GO:0010833)2.71106024
82positive regulation of B cell differentiation (GO:0045579)2.65920792
83regulation of gamma-delta T cell activation (GO:0046643)2.65837333
84regulation of gamma-delta T cell differentiation (GO:0045586)2.65714990
85* protein localization to membrane (GO:0072657)2.65623589
86cellular response to virus (GO:0098586)2.64358775
87detection of other organism (GO:0098543)2.64265060
88protein localization to chromosome, centromeric region (GO:0071459)2.60673295
89negative T cell selection (GO:0043383)2.60383099
90negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.58893875
91response to muramyl dipeptide (GO:0032495)2.58810785
92mRNA splicing, via spliceosome (GO:0000398)2.58687508
93RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.58687508
94* gene expression (GO:0010467)2.58064568
95pentose-phosphate shunt (GO:0006098)2.57961533
96regulation of protein heterodimerization activity (GO:0043497)2.57735836
97RNA splicing, via transesterification reactions (GO:0000375)2.57726979
98positive T cell selection (GO:0043368)2.57229592
99energy coupled proton transport, down electrochemical gradient (GO:0015985)2.56701369
100ATP synthesis coupled proton transport (GO:0015986)2.56701369
101positive regulation of Cdc42 GTPase activity (GO:0043089)2.56127728
102B cell receptor signaling pathway (GO:0050853)2.55238683
103heterochromatin organization (GO:0070828)2.55237042
104positive regulation of histone deacetylation (GO:0031065)2.55207074
105regulation of mammary gland epithelial cell proliferation (GO:0033599)2.53576231
106pseudouridine synthesis (GO:0001522)2.51374002
107negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.50235656
108immunoglobulin mediated immune response (GO:0016064)2.49649212
109regulation of histone H3-K27 methylation (GO:0061085)2.49429621
110negative regulation of mRNA processing (GO:0050686)2.48155160
111regulation of chromatin binding (GO:0035561)2.47976065
112termination of RNA polymerase II transcription (GO:0006369)2.47304809
113peptidyl-arginine omega-N-methylation (GO:0035247)2.46033927
114regulation of type I interferon-mediated signaling pathway (GO:0060338)2.45701321
115regulation of B cell receptor signaling pathway (GO:0050855)2.44725773
116* protein localization to organelle (GO:0033365)2.43143492
117mitotic nuclear envelope disassembly (GO:0007077)2.42349522
118ncRNA processing (GO:0034470)2.41877237
119myeloid dendritic cell differentiation (GO:0043011)2.41655719
120kinetochore organization (GO:0051383)2.41545916
121pinocytosis (GO:0006907)2.41331101
122ribosome biogenesis (GO:0042254)2.40823143
123response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.39602015
124response to host (GO:0075136)2.39602015
125response to host defenses (GO:0052200)2.39602015
126Peyers patch development (GO:0048541)2.39396986
127mucosal-associated lymphoid tissue development (GO:0048537)2.39396986
128cellular response to interleukin-4 (GO:0071353)2.37728781
129ribonucleoprotein complex assembly (GO:0022618)2.37462314
130termination of RNA polymerase III transcription (GO:0006386)2.37082694
131transcription elongation from RNA polymerase III promoter (GO:0006385)2.37082694
132regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.36364421
133regulation of T cell tolerance induction (GO:0002664)2.36202271
134positive regulation of transcription regulatory region DNA binding (GO:2000679)2.35418143
135regulation of interleukin-2 biosynthetic process (GO:0045076)2.35235949
136DNA replication-dependent nucleosome organization (GO:0034723)2.34940405
137DNA replication-dependent nucleosome assembly (GO:0006335)2.34940405
138chromatin remodeling at centromere (GO:0031055)2.33761319
139regulation of defense response to virus by virus (GO:0050690)2.33554387
1403-UTR-mediated mRNA stabilization (GO:0070935)2.32746662
141establishment of integrated proviral latency (GO:0075713)2.31353174
142regulation of B cell differentiation (GO:0045577)2.30888339
143CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.30324325
144pteridine-containing compound biosynthetic process (GO:0042559)2.29784209
145response to laminar fluid shear stress (GO:0034616)2.29199647
146transcription-coupled nucleotide-excision repair (GO:0006283)2.29190013
147viral protein processing (GO:0019082)2.28950320
148activation of MAPKKK activity (GO:0000185)2.28862666
149modulation by virus of host morphology or physiology (GO:0019048)2.28525739
150GDP-mannose metabolic process (GO:0019673)2.28442812
151response to host immune response (GO:0052572)2.28146845
152response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.28146845
153mitotic sister chromatid segregation (GO:0000070)2.27890159
154regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.27260069
155negative regulation of mRNA metabolic process (GO:1903312)2.24153323
156ribonucleoprotein complex subunit organization (GO:0071826)2.24110369
157DNA damage response, detection of DNA damage (GO:0042769)2.24075649
158kinetochore assembly (GO:0051382)2.23747010
159CENP-A containing nucleosome assembly (GO:0034080)2.19472266
160maternal placenta development (GO:0001893)2.19226555
161ncRNA metabolic process (GO:0034660)2.17684781
162negative regulation of translational initiation (GO:0045947)2.17233893
163intra-S DNA damage checkpoint (GO:0031573)2.16206055
164nuclear envelope disassembly (GO:0051081)2.15977416
165membrane disassembly (GO:0030397)2.15977416
166exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.15154016
167T cell apoptotic process (GO:0070231)2.14512028
168trophectodermal cell differentiation (GO:0001829)2.13704144
169IMP biosynthetic process (GO:0006188)2.13651524
170activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.13386692
171* viral transcription (GO:0019083)10.5444163
172* translational termination (GO:0006415)10.0979550

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.19075529
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.30174570
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.99259211
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.94968711
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.50982809
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.38945865
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.95940179
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84287516
9* XRN2_22483619_ChIP-Seq_HELA_Human2.67393634
10* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.67139939
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.62225227
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.61444468
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.60466736
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.49126664
15* LXR_22292898_ChIP-Seq_THP-1_Human2.40155425
16* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.32404402
17MYC_22102868_ChIP-Seq_BL_Human2.29683779
18* GABP_17652178_ChIP-ChIP_JURKAT_Human2.19275422
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17625092
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.11506314
21TTF2_22483619_ChIP-Seq_HELA_Human2.06733316
22* VDR_21846776_ChIP-Seq_THP-1_Human2.05927307
23* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.01460570
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.00993430
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97212179
26* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.93094376
27DCP1A_22483619_ChIP-Seq_HELA_Human1.91901839
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88630847
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.87758079
30* KDM2B_26808549_Chip-Seq_DND41_Human1.87071255
31VDR_23849224_ChIP-Seq_CD4+_Human1.82123971
32* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79046261
33* RACK7_27058665_Chip-Seq_MCF-7_Human1.78269526
34* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78159174
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77190849
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75114942
37FOXP3_21729870_ChIP-Seq_TREG_Human1.73995897
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66918830
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.63762919
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63530231
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61896992
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.61852700
43* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.57338540
44P68_20966046_ChIP-Seq_HELA_Human1.56848957
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56164166
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54769393
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.54477839
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51675100
49KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.51292538
50CIITA_25753668_ChIP-Seq_RAJI_Human1.50539935
51* SA1_27219007_Chip-Seq_ERYTHROID_Human1.47770565
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.44645253
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.44284543
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42456473
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42372800
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.41901103
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41212552
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41027891
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39054015
60* GABP_19822575_ChIP-Seq_HepG2_Human1.38762674
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38124758
62CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38032012
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37370679
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.37105399
65IRF8_22096565_ChIP-ChIP_GC-B_Human1.36598911
66MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36257404
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.34549071
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34192786
69* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33286844
70* NCOR1_26117541_ChIP-Seq_K562_Human1.33081587
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32622646
72ELK1_19687146_ChIP-ChIP_HELA_Human1.30462556
73AR_21909140_ChIP-Seq_LNCAP_Human1.30421217
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30115330
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28610186
76* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28518917
77BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27836234
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27669152
79* KDM2B_26808549_Chip-Seq_JURKAT_Human1.26825123
80KDM5A_27292631_Chip-Seq_BREAST_Human1.26503593
81* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25760845
82BCOR_27268052_Chip-Seq_Bcells_Human1.24928818
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.23673920
84* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22868893
85UTX_26944678_Chip-Seq_JUKART_Human1.22028562
86* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21182720
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20922300
88BCL6_27268052_Chip-Seq_Bcells_Human1.20234444
89STAT4_19710469_ChIP-ChIP_TH1__Mouse1.19997855
90MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18755514
91PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17536111
92MAF_26560356_Chip-Seq_TH1_Human1.17041242
93ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16182748
94MAF_26560356_Chip-Seq_TH2_Human1.15764285
95* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15759484
96SMC4_20622854_ChIP-Seq_HELA_Human1.15557188
97SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15372919
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13827611
99VDR_24763502_ChIP-Seq_THP-1_Human1.13526010
100* CTCF_26484167_Chip-Seq_Bcells_Mouse1.12219345
101ELK1_22589737_ChIP-Seq_MCF10A_Human1.11601928
102ELK3_25401928_ChIP-Seq_HUVEC_Human1.11423220
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11412754
104HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11056856
105PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10949976
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10839260
107BP1_19119308_ChIP-ChIP_Hs578T_Human1.10064289
108* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09486599
109ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09369822
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09242083
111CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09197053
112KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08431435
113KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08431435
114KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08431435
115MYB_26560356_Chip-Seq_TH1_Human1.08060475
116TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07780241
117SCL_19346495_ChIP-Seq_HPC-7_Human1.07630256
118* KDM2B_26808549_Chip-Seq_K562_Human1.06983511
119CREB1_26743006_Chip-Seq_LNCaP_Human1.05435273
120EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04914482
121TP63_19390658_ChIP-ChIP_HaCaT_Human1.04906458
122POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04216262
123* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04027781
124OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03730574
125MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03674095
126* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02569214
127TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02213839
128CTCF_21964334_Chip-Seq_Bcells_Human1.01859984
129KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01417277
130CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00965838
131SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00656167
132SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99922306
133* SPI1_23547873_ChIP-Seq_NB4_Human0.99063590
134TCF7_22412390_ChIP-Seq_EML_Mouse0.98865100
135POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98477159
136* MYC_18940864_ChIP-ChIP_HL60_Human0.98248621
137NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97460927
138HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96864296
139CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96231913
140* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94944767
141* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93523827
142TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93249485
143ZNF263_19887448_ChIP-Seq_K562_Human0.91535960
144* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91150962
145GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89599696
146* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89390867
147BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89282467
148ATF3_27146783_Chip-Seq_COLON_Human0.87344328
149* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86413819
150E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85266450
151TFEB_21752829_ChIP-Seq_HELA_Human0.84315272
152* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83997138

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.95532435
2MP0003693_abnormal_embryo_hatching3.48709578
3MP0004957_abnormal_blastocyst_morpholog3.29811582
4MP0003111_abnormal_nucleus_morphology2.74487960
5MP0003077_abnormal_cell_cycle2.57407139
6MP0010094_abnormal_chromosome_stability2.51519211
7MP0005451_abnormal_body_composition2.42073515
8MP0001835_abnormal_antigen_presentation2.22800660
9MP0008932_abnormal_embryonic_tissue2.10908441
10MP0010030_abnormal_orbit_morphology2.10805988
11MP0000490_abnormal_crypts_of2.02199052
12MP0002396_abnormal_hematopoietic_system1.99866474
13MP0005058_abnormal_lysosome_morphology1.92283695
14MP0005671_abnormal_response_to1.88843316
15MP0008007_abnormal_cellular_replicative1.83946769
16MP0004947_skin_inflammation1.83268759
17MP0009333_abnormal_splenocyte_physiolog1.80950358
18MP0002419_abnormal_innate_immunity1.78504180
19MP0010352_gastrointestinal_tract_polyps1.76060369
20MP0000678_abnormal_parathyroid_gland1.65617206
21MP0003303_peritoneal_inflammation1.65081106
22MP0008260_abnormal_autophagy1.64651786
23MP0003941_abnormal_skin_development1.64591605
24MP0004858_abnormal_nervous_system1.61127205
25MP0000350_abnormal_cell_proliferation1.59313836
26MP0008057_abnormal_DNA_replication1.55764091
27MP0003763_abnormal_thymus_physiology1.54059429
28MP0001730_embryonic_growth_arrest1.52846468
29MP0005501_abnormal_skin_physiology1.51592462
30MP0003300_gastrointestinal_ulcer1.51377072
31MP0009840_abnormal_foam_cell1.46217357
32MP0002796_impaired_skin_barrier1.46201301
33MP0002132_abnormal_respiratory_system1.44906601
34MP0002148_abnormal_hypersensitivity_rea1.42817274
35MP0004381_abnormal_hair_follicle1.40679415
36MP0005464_abnormal_platelet_physiology1.40308715
37MP0003786_premature_aging1.36597440
38MP0000703_abnormal_thymus_morphology1.34691301
39MP0009053_abnormal_anal_canal1.34068291
40MP0003567_abnormal_fetal_cardiomyocyte1.33031849
41MP0004808_abnormal_hematopoietic_stem1.32136980
42MP0009278_abnormal_bone_marrow1.31382597
43MP0005076_abnormal_cell_differentiation1.30333896
44MP0003191_abnormal_cellular_cholesterol1.28469002
45MP0008058_abnormal_DNA_repair1.26190733
46MP0009785_altered_susceptibility_to1.25671761
47MP0001533_abnormal_skeleton_physiology1.25359207
48MP0001853_heart_inflammation1.24906337
49MP0001697_abnormal_embryo_size1.23679485
50MP0001545_abnormal_hematopoietic_system1.23324284
51MP0005397_hematopoietic_system_phenotyp1.23324284
52MP0000685_abnormal_immune_system1.21301028
53MP0003123_paternal_imprinting1.20488109
54MP0002019_abnormal_tumor_incidence1.19397041
55MP0002398_abnormal_bone_marrow1.18946639
56MP0005380_embryogenesis_phenotype1.16659479
57MP0001672_abnormal_embryogenesis/_devel1.16659479
58MP0002722_abnormal_immune_system1.16467230
59MP0002085_abnormal_embryonic_tissue1.15392127
60MP0000313_abnormal_cell_death1.14781116
61MP0002080_prenatal_lethality1.14533679
62MP0010155_abnormal_intestine_physiology1.14205634
63MP0001845_abnormal_inflammatory_respons1.12428974
64MP0000858_altered_metastatic_potential1.11619924
65MP0004510_myositis1.11393773
66MP0001800_abnormal_humoral_immune1.09416340
67MP0005666_abnormal_adipose_tissue1.09165569
68MP0003984_embryonic_growth_retardation1.08351597
69MP0002088_abnormal_embryonic_growth/wei1.08344963
70MP0001851_eye_inflammation1.08280100
71MP0003136_yellow_coat_color1.07728331
72MP0001348_abnormal_lacrimal_gland1.06509712
73MP0005174_abnormal_tail_pigmentation1.05490695
74MP0000049_abnormal_middle_ear1.05439170
75MP0001849_ear_inflammation1.05170169
76MP0002877_abnormal_melanocyte_morpholog1.04727236
77MP0003315_abnormal_perineum_morphology1.03451927
78MP0005023_abnormal_wound_healing1.03337186
79MP0003436_decreased_susceptibility_to1.02862733
80MP0003172_abnormal_lysosome_physiology1.02429345
81MP0003453_abnormal_keratinocyte_physiol1.00616910
82MP0000689_abnormal_spleen_morphology0.99648295
83MP0002086_abnormal_extraembryonic_tissu0.99140610
84MP0004197_abnormal_fetal_growth/weight/0.98802955
85MP0002084_abnormal_developmental_patter0.98402920
86MP0002405_respiratory_system_inflammati0.97645278
87MP0003566_abnormal_cell_adhesion0.96957192
88MP0002060_abnormal_skin_morphology0.96767630
89MP0003705_abnormal_hypodermis_morpholog0.95986069
90MP0002429_abnormal_blood_cell0.95625309
91MP0002998_abnormal_bone_remodeling0.94152982
92MP0000750_abnormal_muscle_regeneration0.94032745
93MP0004185_abnormal_adipocyte_glucose0.93967791
94MP0001216_abnormal_epidermal_layer0.93718717
95MP0006082_CNS_inflammation0.92122242
96MP0003866_abnormal_defecation0.91187030
97MP0008469_abnormal_protein_level0.90864126
98MP0002249_abnormal_larynx_morphology0.90646579
99MP0000477_abnormal_intestine_morphology0.89310818
100MP0000467_abnormal_esophagus_morphology0.89159418
101MP0001873_stomach_inflammation0.88737081
102MP0000716_abnormal_immune_system0.88530917
103MP0000537_abnormal_urethra_morphology0.88483654
104MP0002166_altered_tumor_susceptibility0.88331544
105MP0002098_abnormal_vibrissa_morphology0.87867102
106MP0002089_abnormal_postnatal_growth/wei0.86866783
107MP0002452_abnormal_antigen_presenting0.86640872
108MP0000762_abnormal_tongue_morphology0.86177444
109MP0000465_gastrointestinal_hemorrhage0.85640276
110MP0001663_abnormal_digestive_system0.85189797
111MP0002420_abnormal_adaptive_immunity0.84533847
112MP0003724_increased_susceptibility_to0.83784255
113MP0003828_pulmonary_edema0.83405981
114MP0002111_abnormal_tail_morphology0.83385377
115MP0003806_abnormal_nucleotide_metabolis0.83315361
116MP0001819_abnormal_immune_cell0.82767993
117MP0005375_adipose_tissue_phenotype0.82592229
118MP0004264_abnormal_extraembryonic_tissu0.82318357
119MP0005390_skeleton_phenotype0.82062259
120MP0010307_abnormal_tumor_latency0.81991901
121MP0000613_abnormal_salivary_gland0.81939545
122MP0009931_abnormal_skin_appearance0.78713939
123MP0000377_abnormal_hair_follicle0.77275742
124MP0002933_joint_inflammation0.76714213
125MP0002723_abnormal_immune_serum0.76189856
126MP0000733_abnormal_muscle_development0.76173549
127MP0005381_digestive/alimentary_phenotyp0.76016051
128MP0006054_spinal_hemorrhage0.75941778
129MP0002932_abnormal_joint_morphology0.75015007
130MP0005000_abnormal_immune_tolerance0.74980124
131MP0001790_abnormal_immune_system0.74746443
132MP0005387_immune_system_phenotype0.74746443
133MP0005025_abnormal_response_to0.73930843
134MP0003385_abnormal_body_wall0.73552910
135MP0005310_abnormal_salivary_gland0.71590351
136MP0002277_abnormal_respiratory_mucosa0.68780072
137MP0005075_abnormal_melanosome_morpholog0.65078875
138MP0000681_abnormal_thyroid_gland0.63899724
139MP0003279_aneurysm0.63476873

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)8.37491401
2Abnormality of cells of the erythroid lineage (HP:0012130)8.27642946
3Abnormal number of erythroid precursors (HP:0012131)7.47180956
4Macrocytic anemia (HP:0001972)6.43338369
5Pallor (HP:0000980)5.84561058
6Abnormal hemoglobin (HP:0011902)4.78893114
7Aplasia/Hypoplasia of the sacrum (HP:0008517)4.16195709
8Eczematoid dermatitis (HP:0000976)4.14597805
9Increased IgE level (HP:0003212)3.63217168
10Abnormality of reticulocytes (HP:0004312)3.32356902
11Trismus (HP:0000211)3.29203069
12Obstructive lung disease (HP:0006536)3.14059554
13Chronic obstructive pulmonary disease (HP:0006510)3.14059554
14Gastrointestinal stroma tumor (HP:0100723)3.12821989
15Abnormality of macrophages (HP:0004311)3.05448792
16Thrombocytosis (HP:0001894)3.04673911
17Recurrent abscess formation (HP:0002722)2.99784235
18Agammaglobulinemia (HP:0004432)2.97447905
19Meningitis (HP:0001287)2.89882443
20Recurrent bacterial skin infections (HP:0005406)2.87546264
21Colon cancer (HP:0003003)2.84695260
22Colitis (HP:0002583)2.78694514
23Absent thumb (HP:0009777)2.77167116
24Abnormal delayed hypersensitivity skin test (HP:0002963)2.73292948
25Depressed nasal ridge (HP:0000457)2.70105671
26Concave nail (HP:0001598)2.64409236
27Hypertensive crisis (HP:0100735)2.61978951
28Multiple enchondromatosis (HP:0005701)2.60178381
29Mediastinal lymphadenopathy (HP:0100721)2.60042080
30Panhypogammaglobulinemia (HP:0003139)2.56863539
31Woolly hair (HP:0002224)2.55862120
32Recurrent viral infections (HP:0004429)2.53421860
33Increased hepatocellular lipid droplets (HP:0006565)2.52878688
34Inflammation of the large intestine (HP:0002037)2.51932496
35Emphysema (HP:0002097)2.50474951
36Recurrent fungal infections (HP:0002841)2.49992104
37Oral leukoplakia (HP:0002745)2.49733412
38Polygenic inheritance (HP:0010982)2.41697386
39Abnormality of the fingertips (HP:0001211)2.39383366
40Exertional dyspnea (HP:0002875)2.39144642
41Lymphopenia (HP:0001888)2.38134566
42Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.37501487
43Triphalangeal thumb (HP:0001199)2.36734799
44Thick lower lip vermilion (HP:0000179)2.36446826
45Migraine (HP:0002076)2.34722626
46Abnormality of cells of the lymphoid lineage (HP:0012140)2.32125216
47Hyperacusis (HP:0010780)2.31296175
48Disproportionate tall stature (HP:0001519)2.28059565
49Congenital, generalized hypertrichosis (HP:0004540)2.27447642
50Obstructive sleep apnea (HP:0002870)2.26251687
51Breast hypoplasia (HP:0003187)2.23126536
52Myositis (HP:0100614)2.21261720
53Nasal polyposis (HP:0100582)2.20486296
54Gastrointestinal infarctions (HP:0005244)2.20486020
55Fragile nails (HP:0001808)2.18098413
56Selective tooth agenesis (HP:0001592)2.17738358
57Urticaria (HP:0001025)2.17184767
58Lipid accumulation in hepatocytes (HP:0006561)2.15695444
59Premature skin wrinkling (HP:0100678)2.14821340
6011 pairs of ribs (HP:0000878)2.13529975
61Vasculitis (HP:0002633)2.12786744
62Aplastic anemia (HP:0001915)2.10352364
63Segmental peripheral demyelination/remyelination (HP:0003481)2.10111541
64Atresia of the external auditory canal (HP:0000413)2.08273709
65Mitochondrial inheritance (HP:0001427)2.08206096
66Increased serum ferritin (HP:0003281)2.08137683
67Purpura (HP:0000979)2.07237964
68Rectal prolapse (HP:0002035)2.07175354
69Vertebral compression fractures (HP:0002953)2.06654101
70Abnormality of the nasal mucosa (HP:0000433)2.06491474
71Sparse lateral eyebrow (HP:0005338)2.06309854
72Easy fatigability (HP:0003388)2.05242272
73Progressive muscle weakness (HP:0003323)2.03749786
74Hepatocellular necrosis (HP:0001404)2.02965745
75Rough bone trabeculation (HP:0100670)2.02529680
76Hypoplasia of the radius (HP:0002984)2.02324565
77Deep palmar crease (HP:0006191)2.02237321
78Long palpebral fissure (HP:0000637)1.99000685
79Abnormal gallbladder physiology (HP:0012438)1.97236276
80Cholecystitis (HP:0001082)1.97236276
81Recurrent skin infections (HP:0001581)1.97049930
82Basal cell carcinoma (HP:0002671)1.96996935
83Centrally nucleated skeletal muscle fibers (HP:0003687)1.96829292
84Thoracic kyphosis (HP:0002942)1.96126648
85Aplasia/Hypoplasia of the patella (HP:0006498)1.96047988
86Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.95141389
87Decreased activity of mitochondrial respiratory chain (HP:0008972)1.95141389
88Partial duplication of the phalanx of hand (HP:0009999)1.94735011
89Horseshoe kidney (HP:0000085)1.92702925
90Patellar aplasia (HP:0006443)1.92179612
91Increased density of long bones (HP:0006392)1.91783292
92Abnormality of T cell physiology (HP:0011840)1.91233314
93Increased IgM level (HP:0003496)1.90512062
94Recurrent gram-negative bacterial infections (HP:0005420)1.90414533
95Abnormality of the thoracic spine (HP:0100711)1.89517953
96Hypergammaglobulinemia (HP:0010702)1.88642256
97Spontaneous hematomas (HP:0007420)1.88608778
98Gingivitis (HP:0000230)1.87289198
99Increased intramyocellular lipid droplets (HP:0012240)1.85447558
100Broad face (HP:0000283)1.85378303
101Chronic mucocutaneous candidiasis (HP:0002728)1.85257249
102Recurrent cutaneous fungal infections (HP:0011370)1.85257249
103Asplenia (HP:0001746)1.84669522
104IgM deficiency (HP:0002850)1.84278103
105Seborrheic dermatitis (HP:0001051)1.83964464
106Reticulocytosis (HP:0001923)1.83607889
107Ridged nail (HP:0001807)1.81400780
108Myopathic facies (HP:0002058)1.80488310
109Broad distal phalanx of finger (HP:0009836)1.80325992
110Cleft eyelid (HP:0000625)1.79420871
111Prolonged bleeding time (HP:0003010)1.79263992
112Polycythemia (HP:0001901)1.79016342
113Granulocytopenia (HP:0001913)1.78805225
114Encephalitis (HP:0002383)1.77073414
115Missing ribs (HP:0000921)1.76594781
116Poikiloderma (HP:0001029)1.76561032
117Down-sloping shoulders (HP:0200021)1.76356363
118Papilloma (HP:0012740)1.76313156
119Verrucae (HP:0200043)1.76313156
120Restrictive lung disease (HP:0002091)1.75447808
121Cellulitis (HP:0100658)1.75390412
122Hemorrhage of the eye (HP:0011885)1.75063158
123Skin ulcer (HP:0200042)1.75006019
124Neoplasm of the pancreas (HP:0002894)1.74573052
125Respiratory difficulties (HP:0002880)1.73172149
126Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.72944710
127Rhabdomyosarcoma (HP:0002859)1.72417638
128Malnutrition (HP:0004395)1.71746619
129Aplasia/Hypoplasia of the spleen (HP:0010451)1.71374687
130Stenosis of the external auditory canal (HP:0000402)1.70728508
131Abnormal number of incisors (HP:0011064)1.70409634
132Osteomyelitis (HP:0002754)1.69968314
133Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.69498916
134Gastrointestinal dysmotility (HP:0002579)1.69202524
135Proximal placement of thumb (HP:0009623)1.68616230
136Metaphyseal cupping (HP:0003021)1.68068937
137Abnormality of small intestinal villus morphology (HP:0011472)1.67915776
138Villous atrophy (HP:0011473)1.67915776
139Sepsis (HP:0100806)1.67295778
140Nasolacrimal duct obstruction (HP:0000579)1.67132331
141Renal Fanconi syndrome (HP:0001994)1.66895482
142Pustule (HP:0200039)1.66878375
143Ragged-red muscle fibers (HP:0003200)1.66447307
144Aplasia/Hypoplasia of the thymus (HP:0010515)1.66401085
145Abnormality of the preputium (HP:0100587)1.65491471
146Elevated erythrocyte sedimentation rate (HP:0003565)1.65416219
147Carpal bone hypoplasia (HP:0001498)1.65069963
148Achilles tendon contracture (HP:0001771)1.64975937
149Protrusio acetabuli (HP:0003179)1.64476822
150Hepatosplenomegaly (HP:0001433)1.64042137
151Increased CSF lactate (HP:0002490)1.64029435
152Petechiae (HP:0000967)1.63803009
153Hepatic necrosis (HP:0002605)1.62510330
154Acute necrotizing encephalopathy (HP:0006965)1.61938526
155Partial duplication of thumb phalanx (HP:0009944)1.60631532
156Glossoptosis (HP:0000162)1.60121460
157Hypochromic anemia (HP:0001931)1.59446549
158Premature rupture of membranes (HP:0001788)1.58860241
159Angiofibromas (HP:0010615)1.57558627
160Adenoma sebaceum (HP:0009720)1.57558627
161Absent radius (HP:0003974)1.57229048
162Increased muscle lipid content (HP:0009058)1.55755533
163Deviation of the thumb (HP:0009603)1.52235278
164Tracheoesophageal fistula (HP:0002575)1.52092434
165Sparse eyelashes (HP:0000653)1.51810710
166Secondary amenorrhea (HP:0000869)1.50371516
167Coarctation of aorta (HP:0001680)1.49124950
168Microretrognathia (HP:0000308)1.47778267
169Gastrointestinal inflammation (HP:0004386)1.47254119
170Myelodysplasia (HP:0002863)1.46025953
171Pili torti (HP:0003777)1.45277553
172Abnormal mitochondria in muscle tissue (HP:0008316)1.44297670
173Meckel diverticulum (HP:0002245)1.44286489
174Premature graying of hair (HP:0002216)1.43290698
175Bicuspid aortic valve (HP:0001647)1.43112138
176Abnormality of the parietal bone (HP:0002696)1.42809474
177Preauricular skin tag (HP:0000384)1.42570329

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.58914380
2NME24.36988525
3SMG13.47108908
4PRPF4B3.33932576
5EEF2K3.10326585
6MAP3K102.63812132
7BUB12.61609288
8SIK12.57064679
9EIF2AK12.50995582
10RIPK42.30761622
11RPS6KB22.19318904
12MAP4K12.14673624
13TESK22.10183369
14LRRK22.08436659
15CDC72.01734686
16WEE11.91460938
17PIM21.90869794
18ICK1.88474606
19NEK21.81757120
20PKN21.75944192
21VRK21.74331817
22MAP3K131.67907872
23CDK121.67835167
24IRAK41.63249110
25IRAK31.60613720
26TAOK21.56678232
27BLK1.53384536
28CDK71.47776413
29STK101.40735545
30ILK1.37398086
31SRPK11.37149205
32MKNK21.34839836
33TRIB31.34626680
34CDK191.33505045
35MAP3K111.32317980
36MKNK11.30618137
37AURKB1.26974005
38RPS6KA41.25886220
39MST41.23685237
40FGFR41.23157269
41MAP3K81.21950131
42TNK21.18831221
43ARAF1.18383584
44ERN11.17534771
45CDK41.15690852
46PRKD21.14599659
47SIK21.13433789
48MAP2K21.13100851
49GRK61.11836604
50PASK1.10656218
51PIM11.10083513
52SIK31.09791948
53TTK1.09324604
54DYRK31.08895851
55DAPK31.08421575
56VRK11.08305930
57STK41.06582565
58CLK11.06236606
59TAOK11.05567514
60JAK31.01614311
61PLK11.00825594
62MARK21.00790074
63MAP3K31.00102240
64TGFBR10.98605525
65PAK40.96528362
66NME10.95623453
67HIPK20.92730738
68FLT30.92197448
69EPHB20.90967726
70EPHB10.88938066
71BTK0.87769995
72AURKA0.86176289
73MAP3K10.85644228
74CDC42BPA0.84804480
75BRAF0.83370338
76PDPK10.80885857
77KDR0.80649526
78KSR20.76404200
79MAP3K140.74891293
80MAPKAPK30.74564465
81PAK10.73115054
82RPS6KA50.70954343
83ZAP700.70898405
84ATR0.70387305
85HCK0.69009194
86TESK10.68827783
87IKBKB0.67235049
88CSNK2A20.67156262
89CDK60.66623242
90EPHA20.66274953
91IKBKE0.66030192
92MARK30.65669567
93PAK20.65220595
94SYK0.64839260
95ALK0.64049848
96DYRK1B0.63519276
97STK160.62280266
98BMX0.62029033
99PBK0.61898369
100CHEK10.59967850
101TYRO30.58342270
102PDK10.58177081
103CSF1R0.57687464
104IRAK20.55850965
105NEK90.55693311
106CDK80.55229654
107RIPK10.53003942
108LYN0.51978893
109CDK20.51926719
110CDK90.51692195
111CSNK2A10.51683957
112MAPK120.51564392
113ITK0.51378313
114PRKD30.51136470
115NLK0.50566561
116CSK0.50202690
117RPS6KL10.49978980
118RPS6KC10.49978980
119TEC0.49787664
120CHEK20.48373814
121RPS6KA60.47306106
122TBK10.47274751
123TYK20.45143663
124RPS6KA10.43119448
125SCYL20.42799205
126TSSK60.42566307
127ATM0.42111025
128FES0.41522067
129RPS6KA20.41272634
130LCK0.41030778
131BRD40.40827022
132MAP2K30.39848398
133BRSK20.39535641
134MTOR0.39176006
135KIT0.38825121
136MAPKAPK20.38754385
137MAPK110.38628672
138MAP3K70.38200692
139LIMK10.37870489
140PTK60.37856120
141AKT20.36933515
142TTN0.36707098
143DMPK0.36614748
144PRKCI0.36109801
145MELK0.33646244
146MAPK70.32729132
147CAMKK10.32258162

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030108.02173505
2DNA replication_Homo sapiens_hsa030303.78853915
3Mismatch repair_Homo sapiens_hsa034303.12578398
4Spliceosome_Homo sapiens_hsa030403.06724318
5RNA polymerase_Homo sapiens_hsa030202.73937784
6Homologous recombination_Homo sapiens_hsa034402.62596048
7Base excision repair_Homo sapiens_hsa034102.33960641
8One carbon pool by folate_Homo sapiens_hsa006702.29822276
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.23101606
10Nucleotide excision repair_Homo sapiens_hsa034202.09985936
11RNA transport_Homo sapiens_hsa030132.07684672
12Proteasome_Homo sapiens_hsa030502.04521780
13Other glycan degradation_Homo sapiens_hsa005111.93219369
14Pyrimidine metabolism_Homo sapiens_hsa002401.90264676
15Allograft rejection_Homo sapiens_hsa053301.73988125
16Osteoclast differentiation_Homo sapiens_hsa043801.72624251
17Sulfur relay system_Homo sapiens_hsa041221.72574649
18Parkinsons disease_Homo sapiens_hsa050121.69175052
19Autoimmune thyroid disease_Homo sapiens_hsa053201.66360885
20Cell cycle_Homo sapiens_hsa041101.64435485
21Oxidative phosphorylation_Homo sapiens_hsa001901.61024732
22Graft-versus-host disease_Homo sapiens_hsa053321.57984419
23Fanconi anemia pathway_Homo sapiens_hsa034601.52999438
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.51298467
25Pancreatic cancer_Homo sapiens_hsa052121.40336607
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38150531
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.37662709
28Huntingtons disease_Homo sapiens_hsa050161.32980930
29Systemic lupus erythematosus_Homo sapiens_hsa053221.31663801
30mRNA surveillance pathway_Homo sapiens_hsa030151.28461884
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26853675
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25852765
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22006727
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21896299
35p53 signaling pathway_Homo sapiens_hsa041151.18643708
36Primary immunodeficiency_Homo sapiens_hsa053401.16127003
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15601409
38Protein export_Homo sapiens_hsa030601.15106486
39RNA degradation_Homo sapiens_hsa030181.14577191
40Non-homologous end-joining_Homo sapiens_hsa034501.14246058
41Basal transcription factors_Homo sapiens_hsa030221.13839694
42Renal cell carcinoma_Homo sapiens_hsa052111.12314018
43Hepatitis C_Homo sapiens_hsa051601.05187823
44Alzheimers disease_Homo sapiens_hsa050101.02085114
45Herpes simplex infection_Homo sapiens_hsa051681.01013817
46Central carbon metabolism in cancer_Homo sapiens_hsa052300.99995005
47Fructose and mannose metabolism_Homo sapiens_hsa000510.97611471
48Bladder cancer_Homo sapiens_hsa052190.97386209
49Epstein-Barr virus infection_Homo sapiens_hsa051690.95619001
50Tuberculosis_Homo sapiens_hsa051520.94388661
51Staphylococcus aureus infection_Homo sapiens_hsa051500.94339785
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.94183418
53Endometrial cancer_Homo sapiens_hsa052130.91867929
54Prion diseases_Homo sapiens_hsa050200.91016019
55Colorectal cancer_Homo sapiens_hsa052100.90769563
56Antigen processing and presentation_Homo sapiens_hsa046120.88163272
57Chemokine signaling pathway_Homo sapiens_hsa040620.84672182
58HTLV-I infection_Homo sapiens_hsa051660.83834110
59TNF signaling pathway_Homo sapiens_hsa046680.81393438
60mTOR signaling pathway_Homo sapiens_hsa041500.80343972
61Type I diabetes mellitus_Homo sapiens_hsa049400.80156611
62Viral carcinogenesis_Homo sapiens_hsa052030.79813217
63Pentose phosphate pathway_Homo sapiens_hsa000300.79463818
64Basal cell carcinoma_Homo sapiens_hsa052170.76683637
65Acute myeloid leukemia_Homo sapiens_hsa052210.75310228
66Notch signaling pathway_Homo sapiens_hsa043300.74847837
67Thyroid cancer_Homo sapiens_hsa052160.74592333
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72705056
69Purine metabolism_Homo sapiens_hsa002300.72250658
70Small cell lung cancer_Homo sapiens_hsa052220.71125576
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70913053
72Chronic myeloid leukemia_Homo sapiens_hsa052200.70521974
73Folate biosynthesis_Homo sapiens_hsa007900.69281700
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.67649788
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66623167
76Galactose metabolism_Homo sapiens_hsa000520.66149263
77ErbB signaling pathway_Homo sapiens_hsa040120.65966306
78MicroRNAs in cancer_Homo sapiens_hsa052060.64157871
79African trypanosomiasis_Homo sapiens_hsa051430.63092025
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62930443
81Hematopoietic cell lineage_Homo sapiens_hsa046400.62431106
82Endocytosis_Homo sapiens_hsa041440.62142741
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61664975
84Choline metabolism in cancer_Homo sapiens_hsa052310.57737359
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57550074
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56418084
87Apoptosis_Homo sapiens_hsa042100.56310763
88Insulin signaling pathway_Homo sapiens_hsa049100.54707339
89Prolactin signaling pathway_Homo sapiens_hsa049170.54422246
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.52019644
91Glutathione metabolism_Homo sapiens_hsa004800.51129054
92B cell receptor signaling pathway_Homo sapiens_hsa046620.51068183
93Glioma_Homo sapiens_hsa052140.51036420
94Measles_Homo sapiens_hsa051620.50716146
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.49367130
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49111993
97Hepatitis B_Homo sapiens_hsa051610.47270391
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46918783
99Leishmaniasis_Homo sapiens_hsa051400.46229499
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.45614006
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.44529242
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44426886
103Salmonella infection_Homo sapiens_hsa051320.43858102
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42869370
105Shigellosis_Homo sapiens_hsa051310.42189712
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41576828
107Cardiac muscle contraction_Homo sapiens_hsa042600.41110841
108Viral myocarditis_Homo sapiens_hsa054160.40908570
109Insulin resistance_Homo sapiens_hsa049310.40682303
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40184797
111Pathways in cancer_Homo sapiens_hsa052000.39154008
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.38413628
113MAPK signaling pathway_Homo sapiens_hsa040100.37847603
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.37291517
115Legionellosis_Homo sapiens_hsa051340.36804525
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36294697
117HIF-1 signaling pathway_Homo sapiens_hsa040660.36130663
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35389044
119Alcoholism_Homo sapiens_hsa050340.34482861
120Hippo signaling pathway_Homo sapiens_hsa043900.33039902
121Hedgehog signaling pathway_Homo sapiens_hsa043400.32740412
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32596002
123Malaria_Homo sapiens_hsa051440.32276381
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31993020
125Proteoglycans in cancer_Homo sapiens_hsa052050.31268064
126Biosynthesis of amino acids_Homo sapiens_hsa012300.30834957
127TGF-beta signaling pathway_Homo sapiens_hsa043500.30809402
128T cell receptor signaling pathway_Homo sapiens_hsa046600.30491735
129Toxoplasmosis_Homo sapiens_hsa051450.30236096
130Influenza A_Homo sapiens_hsa051640.30127864
131Non-small cell lung cancer_Homo sapiens_hsa052230.28821974
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28039512
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27167436
134Adherens junction_Homo sapiens_hsa045200.27149534
135RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26959241
136Prostate cancer_Homo sapiens_hsa052150.26189910
137Arachidonic acid metabolism_Homo sapiens_hsa005900.25692272
138Asthma_Homo sapiens_hsa053100.25680052
139Lysine degradation_Homo sapiens_hsa003100.24747257
140Drug metabolism - other enzymes_Homo sapiens_hsa009830.24432930
141Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21641946
142VEGF signaling pathway_Homo sapiens_hsa043700.21411388
143Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21336839
144ECM-receptor interaction_Homo sapiens_hsa045120.20543836

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