RPL29

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29E family of ribosomal proteins. The protein is also a peripheral membrane protein expressed on the cell surface that directly binds heparin. Although this gene was previously reported to map to 3q29-qter, it is believed that it is located at 3p21.3-p21.2. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.38746804
2* viral transcription (GO:0019083)6.87082983
3* translational termination (GO:0006415)6.61433412
4* translational elongation (GO:0006414)5.86846948
5ribosomal small subunit biogenesis (GO:0042274)5.72767585
6* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.68072671
7* protein targeting to ER (GO:0045047)5.53056542
8* cotranslational protein targeting to membrane (GO:0006613)5.51693463
9maturation of SSU-rRNA (GO:0030490)5.45715681
10* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.35433673
11* establishment of protein localization to endoplasmic reticulum (GO:0072599)5.25591863
12* viral life cycle (GO:0019058)5.18070163
13* protein localization to endoplasmic reticulum (GO:0070972)5.16674555
14* translational initiation (GO:0006413)5.13089695
15* cellular protein complex disassembly (GO:0043624)5.12026820
16* protein complex disassembly (GO:0043241)4.63319752
17ribosomal large subunit biogenesis (GO:0042273)4.53082781
18* macromolecular complex disassembly (GO:0032984)4.30895516
19formation of translation preinitiation complex (GO:0001731)4.29422497
20DNA deamination (GO:0045006)4.15464662
21DNA strand elongation involved in DNA replication (GO:0006271)4.12984396
22DNA unwinding involved in DNA replication (GO:0006268)4.09624581
23* nuclear-transcribed mRNA catabolic process (GO:0000956)4.00817209
24telomere maintenance via semi-conservative replication (GO:0032201)3.98354450
25DNA strand elongation (GO:0022616)3.92351636
26* mRNA catabolic process (GO:0006402)3.81701273
27ribonucleoprotein complex biogenesis (GO:0022613)3.77239646
28regulation of translational fidelity (GO:0006450)3.72286587
29* translation (GO:0006412)3.68936368
30* RNA catabolic process (GO:0006401)3.65945734
31* protein targeting to membrane (GO:0006612)3.60102076
32DNA replication initiation (GO:0006270)3.45783531
33negative regulation of RNA splicing (GO:0033119)3.44707971
34telomere maintenance via recombination (GO:0000722)3.43474684
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.41819264
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.41819264
37mitotic recombination (GO:0006312)3.25966349
38proline biosynthetic process (GO:0006561)3.19980317
39mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.18221131
40rRNA processing (GO:0006364)3.14144409
41antigen processing and presentation of endogenous antigen (GO:0019883)3.06090145
42mitotic chromosome condensation (GO:0007076)3.05715534
43negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.04453682
44rRNA metabolic process (GO:0016072)3.02710899
45protein localization to kinetochore (GO:0034501)3.00601332
46telomere maintenance via telomere lengthening (GO:0010833)2.97654538
47IMP biosynthetic process (GO:0006188)2.96956288
48folic acid-containing compound biosynthetic process (GO:0009396)2.96828190
49* protein targeting (GO:0006605)2.96210683
50oxidative phosphorylation (GO:0006119)2.93991533
51pentose-phosphate shunt (GO:0006098)2.93510877
52ribosome assembly (GO:0042255)2.93214978
53peptidyl-arginine omega-N-methylation (GO:0035247)2.92509448
54DNA replication checkpoint (GO:0000076)2.90268288
55nucleobase biosynthetic process (GO:0046112)2.88047363
56establishment of viral latency (GO:0019043)2.87321532
57nucleotide-excision repair, DNA gap filling (GO:0006297)2.87121339
58nucleobase-containing small molecule interconversion (GO:0015949)2.85571220
59deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.83571761
60ribosome biogenesis (GO:0042254)2.80728697
61regulation of mammary gland epithelial cell proliferation (GO:0033599)2.74963470
62mitotic nuclear envelope disassembly (GO:0007077)2.73708942
63energy coupled proton transport, down electrochemical gradient (GO:0015985)2.72352481
64ATP synthesis coupled proton transport (GO:0015986)2.72352481
65regulation of protein heterodimerization activity (GO:0043497)2.72277036
66IMP metabolic process (GO:0046040)2.72205135
67cellular component biogenesis (GO:0044085)2.70691120
68T cell apoptotic process (GO:0070231)2.69285054
69NADPH regeneration (GO:0006740)2.68316108
70protein localization to chromosome, centromeric region (GO:0071459)2.67765457
71ncRNA 3-end processing (GO:0043628)2.63922447
72spliceosomal snRNP assembly (GO:0000387)2.63405530
73pseudouridine synthesis (GO:0001522)2.62922109
74regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.61914843
75protein maturation by protein folding (GO:0022417)2.58326938
76ribonucleoprotein complex assembly (GO:0022618)2.58168834
77guanosine-containing compound biosynthetic process (GO:1901070)2.56442266
78* protein localization to membrane (GO:0072657)2.56046461
79rRNA transcription (GO:0009303)2.52667542
80termination of RNA polymerase II transcription (GO:0006369)2.51939352
81negative regulation of mRNA processing (GO:0050686)2.51441078
82regulation of mitochondrial translation (GO:0070129)2.51112447
83mitochondrial fusion (GO:0008053)2.50140419
84Arp2/3 complex-mediated actin nucleation (GO:0034314)2.50133449
85spliceosomal tri-snRNP complex assembly (GO:0000244)2.50052467
86CENP-A containing nucleosome assembly (GO:0034080)2.49273270
87RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.49161231
88mRNA splicing, via spliceosome (GO:0000398)2.49161231
893-UTR-mediated mRNA stabilization (GO:0070935)2.47970303
90membrane disassembly (GO:0030397)2.47922668
91nuclear envelope disassembly (GO:0051081)2.47922668
92myeloid cell homeostasis (GO:0002262)2.47591114
93positive regulation of gamma-delta T cell activation (GO:0046645)2.47405052
94chromatin remodeling at centromere (GO:0031055)2.47187740
95RNA splicing, via transesterification reactions (GO:0000375)2.47155642
96establishment of integrated proviral latency (GO:0075713)2.46794666
97negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.46499387
98transcription-coupled nucleotide-excision repair (GO:0006283)2.45600045
99translesion synthesis (GO:0019985)2.44961105
100NADH metabolic process (GO:0006734)2.44919871
101negative regulation of erythrocyte differentiation (GO:0045647)2.44727191
102DNA topological change (GO:0006265)2.44211676
103histone arginine methylation (GO:0034969)2.43523273
104GDP-mannose metabolic process (GO:0019673)2.41899382
105ribonucleoprotein complex subunit organization (GO:0071826)2.41694498
106transcription from mitochondrial promoter (GO:0006390)2.40936333
107pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.40309523
108DNA duplex unwinding (GO:0032508)2.39803770
109protein targeting to mitochondrion (GO:0006626)2.39692151
110DNA replication-independent nucleosome assembly (GO:0006336)2.39542677
111DNA replication-independent nucleosome organization (GO:0034724)2.39542677
112antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.39178802
113negative regulation of phagocytosis (GO:0050765)2.39170043
114purine nucleobase biosynthetic process (GO:0009113)2.39051017
115pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.38568284
116pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.37631799
117DNA geometric change (GO:0032392)2.36286250
118viral mRNA export from host cell nucleus (GO:0046784)2.35708643
119negative regulation of ligase activity (GO:0051352)2.35291794
120negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.35291794
121base-excision repair (GO:0006284)2.35205863
122* establishment of protein localization to membrane (GO:0090150)2.35160945
123antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.34853319
124* cellular component disassembly (GO:0022411)2.33242410
125kinetochore organization (GO:0051383)2.32537838
126histone mRNA metabolic process (GO:0008334)2.32350964
127lymphocyte apoptotic process (GO:0070227)2.32108894
128aerobic respiration (GO:0009060)2.31714259
129telomere maintenance (GO:0000723)2.30813672
130anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.30739937
131telomere organization (GO:0032200)2.30572105
132regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.29915400
133exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.29439125
134heterochromatin organization (GO:0070828)2.27931538
135regulation of gamma-delta T cell differentiation (GO:0045586)2.27296794
136* establishment of protein localization to organelle (GO:0072594)2.27157005
137positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.27108829
138* gene expression (GO:0010467)2.26841172
139DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.26508541

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.36486314
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.98370687
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.81081009
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.92200551
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.75311488
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.67594325
7MYC_22102868_ChIP-Seq_BL_Human2.62902671
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.47230241
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.45828387
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.43831529
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.41597716
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.37538104
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31914940
14* GABP_17652178_ChIP-ChIP_JURKAT_Human2.31354085
15* XRN2_22483619_ChIP-Seq_HELA_Human2.29350236
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.27120868
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.21295333
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.17930239
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16328001
20VDR_21846776_ChIP-Seq_THP-1_Human2.14163485
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.12390759
22TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.11054517
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.09999784
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04821695
25* VDR_23849224_ChIP-Seq_CD4+_Human1.97596995
26NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84893676
27* FOXP3_21729870_ChIP-Seq_TREG_Human1.79283373
28CIITA_25753668_ChIP-Seq_RAJI_Human1.77820771
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76494838
30* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74754964
31DCP1A_22483619_ChIP-Seq_HELA_Human1.71371592
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.68029287
33* TTF2_22483619_ChIP-Seq_HELA_Human1.67653151
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.66116181
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.63488594
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60597329
37* GABP_19822575_ChIP-Seq_HepG2_Human1.59871547
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58428893
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.58249084
40ZNF263_19887448_ChIP-Seq_K562_Human1.57934698
41* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57869678
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.57814132
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53273417
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.52113283
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49414945
46SPI1_23547873_ChIP-Seq_NB4_Human1.48882803
47ERG_20887958_ChIP-Seq_HPC-7_Mouse1.45813496
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43411700
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38251335
50MAF_26560356_Chip-Seq_TH1_Human1.37046081
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36533634
52* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35174171
53AR_21909140_ChIP-Seq_LNCAP_Human1.33474728
54SCL_19346495_ChIP-Seq_HPC-7_Human1.33210683
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32525425
56* ELK1_19687146_ChIP-ChIP_HELA_Human1.31996841
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31199931
58* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30434739
59CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30348574
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29488811
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29483057
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29062405
63UTX_26944678_Chip-Seq_JUKART_Human1.28656241
64* LXR_22292898_ChIP-Seq_THP-1_Human1.28385304
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27628839
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27289054
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26640968
68MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26444243
69KDM5A_27292631_Chip-Seq_BREAST_Human1.26417824
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25279047
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24917242
72MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24449037
73VDR_24763502_ChIP-Seq_THP-1_Human1.24273353
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23013790
75MYB_26560356_Chip-Seq_TH2_Human1.22733134
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21660685
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.20032730
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19403762
79NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18671979
80TET1_21451524_ChIP-Seq_MESCs_Mouse1.17808051
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.16266159
82MAF_26560356_Chip-Seq_TH2_Human1.15251435
83* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14224857
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13918635
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12864495
86MYB_26560356_Chip-Seq_TH1_Human1.12679642
87RACK7_27058665_Chip-Seq_MCF-7_Human1.12590097
88SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12443816
89RUNX1_22412390_ChIP-Seq_EML_Mouse1.11702414
90TP63_17297297_ChIP-ChIP_HaCaT_Human1.10618469
91SRF_21415370_ChIP-Seq_HL-1_Mouse1.09319583
92GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08804385
93NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08351119
94ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07352842
95* TCF7_22412390_ChIP-Seq_EML_Mouse1.07330469
96* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07101952
97STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06546809
98BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05404995
99TFEB_21752829_ChIP-Seq_HELA_Human1.04856187
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04855633
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04595626
102TP63_19390658_ChIP-ChIP_HaCaT_Human1.03000877
103YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02629903
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01342692
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00893617
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00837241
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00122755
108STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00115974
109CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99720318
110ELK3_25401928_ChIP-Seq_HUVEC_Human0.99157963
111* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99110048
112CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98207481
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96503681
114CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96081677
115GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95821323
116NCOR1_26117541_ChIP-Seq_K562_Human0.95773040
117ELF1_20517297_ChIP-Seq_JURKAT_Human0.95478991
118P68_20966046_ChIP-Seq_HELA_Human0.95196486
119IRF8_21731497_ChIP-ChIP_J774_Mouse0.94935209
120SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.94198599
121ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93997731
122CTCF_26484167_Chip-Seq_Bcells_Mouse0.93779127
123CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92705009
124HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91230453
125BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91197304

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.12815407
2MP0004957_abnormal_blastocyst_morpholog3.13466353
3MP0002396_abnormal_hematopoietic_system3.10817837
4MP0010094_abnormal_chromosome_stability2.89529160
5MP0003111_abnormal_nucleus_morphology2.82410316
6* MP0003077_abnormal_cell_cycle2.67398642
7MP0003763_abnormal_thymus_physiology2.52160323
8MP0001835_abnormal_antigen_presentation2.49382589
9MP0008057_abnormal_DNA_replication2.33503583
10MP0005451_abnormal_body_composition2.31128639
11MP0009333_abnormal_splenocyte_physiolog2.26845294
12MP0000685_abnormal_immune_system2.23357613
13MP0004808_abnormal_hematopoietic_stem2.21176997
14MP0008007_abnormal_cellular_replicative2.16736257
15MP0000490_abnormal_crypts_of2.13273427
16MP0010352_gastrointestinal_tract_polyps2.07063369
17MP0005397_hematopoietic_system_phenotyp2.03196198
18MP0001545_abnormal_hematopoietic_system2.03196198
19MP0008058_abnormal_DNA_repair2.02937005
20MP0002398_abnormal_bone_marrow2.01940810
21MP0003436_decreased_susceptibility_to1.93603952
22MP0006054_spinal_hemorrhage1.92697846
23MP0010030_abnormal_orbit_morphology1.89494556
24MP0001800_abnormal_humoral_immune1.87795521
25MP0005671_abnormal_response_to1.84474023
26MP0003806_abnormal_nucleotide_metabolis1.81832900
27MP0002722_abnormal_immune_system1.75277551
28MP0002420_abnormal_adaptive_immunity1.70031270
29MP0009785_altered_susceptibility_to1.68942487
30MP0002452_abnormal_antigen_presenting1.68897936
31MP0000703_abnormal_thymus_morphology1.68220442
32MP0002166_altered_tumor_susceptibility1.68147666
33MP0000689_abnormal_spleen_morphology1.67640975
34MP0001819_abnormal_immune_cell1.67624319
35MP0003303_peritoneal_inflammation1.66133061
36MP0005025_abnormal_response_to1.63933459
37MP0004185_abnormal_adipocyte_glucose1.62678829
38MP0000716_abnormal_immune_system1.61969493
39MP0009278_abnormal_bone_marrow1.59077427
40MP0005000_abnormal_immune_tolerance1.58771193
41MP0002723_abnormal_immune_serum1.58004704
42MP0002429_abnormal_blood_cell1.57867352
43MP0002796_impaired_skin_barrier1.56132835
44MP0002405_respiratory_system_inflammati1.53305478
45MP0002019_abnormal_tumor_incidence1.52408934
46MP0001853_heart_inflammation1.51004945
47MP0009379_abnormal_foot_pigmentation1.50382577
48MP0001873_stomach_inflammation1.49441533
49MP0010155_abnormal_intestine_physiology1.47667021
50MP0000465_gastrointestinal_hemorrhage1.47253185
51MP0000858_altered_metastatic_potential1.46737246
52MP0005387_immune_system_phenotype1.46494661
53MP0001790_abnormal_immune_system1.46494661
54* MP0000350_abnormal_cell_proliferation1.45748204
55MP0001730_embryonic_growth_arrest1.44721963
56MP0008932_abnormal_embryonic_tissue1.43822192
57MP0000537_abnormal_urethra_morphology1.42421632
58MP0002006_tumorigenesis1.41535464
59MP0002148_abnormal_hypersensitivity_rea1.40316093
60MP0003315_abnormal_perineum_morphology1.38983354
61MP0008260_abnormal_autophagy1.35623623
62MP0000313_abnormal_cell_death1.29357335
63MP0005464_abnormal_platelet_physiology1.27763940
64MP0009672_abnormal_birth_weight1.25144212
65MP0001346_abnormal_lacrimal_gland1.24760578
66MP0003866_abnormal_defecation1.20590236
67MP0002419_abnormal_innate_immunity1.19423666
68MP0000678_abnormal_parathyroid_gland1.19025197
69MP0003786_premature_aging1.18932103
70MP0010307_abnormal_tumor_latency1.16985729
71MP0005174_abnormal_tail_pigmentation1.16880794
72MP0002877_abnormal_melanocyte_morpholog1.16455879
73MP0006035_abnormal_mitochondrial_morpho1.14130362
74MP0003300_gastrointestinal_ulcer1.11347975
75MP0001845_abnormal_inflammatory_respons1.10237726
76MP0005076_abnormal_cell_differentiation1.09990576
77MP0002132_abnormal_respiratory_system1.09913879
78MP0003123_paternal_imprinting1.07081666
79MP0005666_abnormal_adipose_tissue1.05976892
80MP0004858_abnormal_nervous_system1.04723426
81MP0002080_prenatal_lethality1.04520887
82MP0001849_ear_inflammation1.02109259
83MP0004947_skin_inflammation1.01758367
84MP0001697_abnormal_embryo_size1.00202787
85MP0003724_increased_susceptibility_to0.96781301
86MP0001881_abnormal_mammary_gland0.96234940
87MP0003567_abnormal_fetal_cardiomyocyte0.95727014
88MP0001661_extended_life_span0.94798420
89MP0005075_abnormal_melanosome_morpholog0.94546054
90MP0002009_preneoplasia0.92166391
91MP0004264_abnormal_extraembryonic_tissu0.91009185
92MP0003718_maternal_effect0.90733681
93MP0002163_abnormal_gland_morphology0.90367656
94MP0005023_abnormal_wound_healing0.89728759
95MP0002086_abnormal_extraembryonic_tissu0.89436029
96MP0000733_abnormal_muscle_development0.87924186
97MP0008995_early_reproductive_senescence0.87913482
98MP0003186_abnormal_redox_activity0.87912105
99MP0004381_abnormal_hair_follicle0.86863195
100MP0005058_abnormal_lysosome_morphology0.86577696
101MP0002095_abnormal_skin_pigmentation0.86533686
102* MP0001672_abnormal_embryogenesis/_devel0.86070642
103* MP0005380_embryogenesis_phenotype0.86070642
104MP0002249_abnormal_larynx_morphology0.85979484
105MP0004197_abnormal_fetal_growth/weight/0.84046011
106* MP0003984_embryonic_growth_retardation0.83726828
107MP0000477_abnormal_intestine_morphology0.83382477
108MP0003705_abnormal_hypodermis_morpholog0.82800401
109MP0005501_abnormal_skin_physiology0.82511347
110* MP0002088_abnormal_embryonic_growth/wei0.81451140
111MP0002933_joint_inflammation0.78142839
112MP0003448_altered_tumor_morphology0.76627087
113MP0003566_abnormal_cell_adhesion0.76340143
114MP0001533_abnormal_skeleton_physiology0.75136000
115MP0000750_abnormal_muscle_regeneration0.74668856
116MP0003191_abnormal_cellular_cholesterol0.74366890
117MP0000358_abnormal_cell_content/0.73964800
118MP0001348_abnormal_lacrimal_gland0.73962729
119MP0000372_irregular_coat_pigmentation0.72774998
120MP0004233_abnormal_muscle_weight0.72482107
121MP0003453_abnormal_keratinocyte_physiol0.72401666
122MP0010234_abnormal_vibrissa_follicle0.71667209
123MP0008469_abnormal_protein_level0.71494749
124MP0003656_abnormal_erythrocyte_physiolo0.70905503
125MP0002085_abnormal_embryonic_tissue0.69885389
126MP0001663_abnormal_digestive_system0.69064802
127MP0005384_cellular_phenotype0.67476568
128MP0009053_abnormal_anal_canal0.65842242
129MP0009931_abnormal_skin_appearance0.64934625
130MP0002084_abnormal_developmental_patter0.62522490
131MP0005220_abnormal_exocrine_pancreas0.61850146
132MP0001216_abnormal_epidermal_layer0.59301179
133MP0006036_abnormal_mitochondrial_physio0.58545667
134MP0001915_intracranial_hemorrhage0.55932068
135MP0005621_abnormal_cell_physiology0.55574935

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.51587798
2Abnormal number of erythroid precursors (HP:0012131)6.13439602
3Reticulocytopenia (HP:0001896)5.76877219
4Thrombocytosis (HP:0001894)4.57991779
5Pallor (HP:0000980)4.03844475
6Macrocytic anemia (HP:0001972)3.92318287
7Microvesicular hepatic steatosis (HP:0001414)3.78711917
8Aplastic anemia (HP:0001915)3.71869381
9IgM deficiency (HP:0002850)3.49441679
10Elevated erythrocyte sedimentation rate (HP:0003565)3.30736612
11Progressive muscle weakness (HP:0003323)3.22947207
12Colon cancer (HP:0003003)3.12324821
13Chronic otitis media (HP:0000389)3.00648344
14Petechiae (HP:0000967)2.98969900
15Microretrognathia (HP:0000308)2.95881829
16Oral leukoplakia (HP:0002745)2.92561465
17Aplasia/Hypoplasia of the sacrum (HP:0008517)2.72809616
18Cholecystitis (HP:0001082)2.70375712
19Abnormal gallbladder physiology (HP:0012438)2.70375712
20Multiple enchondromatosis (HP:0005701)2.60779329
21Recurrent viral infections (HP:0004429)2.59262772
22Nasal polyposis (HP:0100582)2.58501825
23Agammaglobulinemia (HP:0004432)2.57577082
24Recurrent bronchitis (HP:0002837)2.57190744
25Abnormality of T cells (HP:0002843)2.56050128
2611 pairs of ribs (HP:0000878)2.54118748
27Myositis (HP:0100614)2.53574583
28Abnormality of T cell physiology (HP:0011840)2.53447278
29Respiratory difficulties (HP:0002880)2.50207621
30Selective tooth agenesis (HP:0001592)2.44135217
31Abnormality of reticulocytes (HP:0004312)2.38231569
32Abnormality of the nasal mucosa (HP:0000433)2.36936932
33Myopathic facies (HP:0002058)2.35698127
34Ragged-red muscle fibers (HP:0003200)2.34577902
35Trismus (HP:0000211)2.33971554
36Cellulitis (HP:0100658)2.32414889
37Increased intramyocellular lipid droplets (HP:0012240)2.32250770
38Eczematoid dermatitis (HP:0000976)2.28868193
39Progressive external ophthalmoplegia (HP:0000590)2.27421119
40Myelodysplasia (HP:0002863)2.26621149
41Poikiloderma (HP:0001029)2.24586001
42Abnormality of the fingertips (HP:0001211)2.24585949
43T lymphocytopenia (HP:0005403)2.23860888
44Recurrent abscess formation (HP:0002722)2.23396397
45Increased muscle lipid content (HP:0009058)2.23233171
46Birth length less than 3rd percentile (HP:0003561)2.22940974
47Colitis (HP:0002583)2.22628268
48Abnormality of the anterior horn cell (HP:0006802)2.22149595
49Degeneration of anterior horn cells (HP:0002398)2.22149595
50Rhabdomyolysis (HP:0003201)2.21528941
51Lymphoma (HP:0002665)2.20937332
52Absent thumb (HP:0009777)2.20596203
53Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20021054
54Recurrent fungal infections (HP:0002841)2.18248155
55Testicular atrophy (HP:0000029)2.17799873
56Gastrointestinal stroma tumor (HP:0100723)2.17749471
57Basal cell carcinoma (HP:0002671)2.17201844
58Seborrheic dermatitis (HP:0001051)2.16283948
59Broad distal phalanx of finger (HP:0009836)2.15048804
60Abnormality of T cell number (HP:0011839)2.12730412
61Increased hepatocellular lipid droplets (HP:0006565)2.12712947
62Abnormality of cells of the lymphoid lineage (HP:0012140)2.11900486
63Abnormality of glycolysis (HP:0004366)2.10953098
64Panhypogammaglobulinemia (HP:0003139)2.09074705
65Hypertensive crisis (HP:0100735)2.08763361
66Abnormality of the umbilical cord (HP:0010881)2.08536795
67Premature skin wrinkling (HP:0100678)2.08055298
68Premature ovarian failure (HP:0008209)2.07341084
69Rectal prolapse (HP:0002035)2.06409942
70Rough bone trabeculation (HP:0100670)2.05782249
71Lymphopenia (HP:0001888)2.05365117
72Recurrent bacterial skin infections (HP:0005406)2.03703346
73Pustule (HP:0200039)2.00036877
74Prolonged bleeding time (HP:0003010)1.99435145
75B lymphocytopenia (HP:0010976)1.99270972
76Abnormality of B cell number (HP:0010975)1.99270972
77Abnormal delayed hypersensitivity skin test (HP:0002963)1.99180917
78Bicuspid aortic valve (HP:0001647)1.98890339
79Centrally nucleated skeletal muscle fibers (HP:0003687)1.98271406
80Gastrointestinal inflammation (HP:0004386)1.95500662
81Meningitis (HP:0001287)1.95320795
82Increased IgE level (HP:0003212)1.94051857
83Vertebral compression fractures (HP:0002953)1.93050613
84Amaurosis fugax (HP:0100576)1.92156127
85Exercise intolerance (HP:0003546)1.91846315
86Agnosia (HP:0010524)1.90019268
87Hepatocellular necrosis (HP:0001404)1.86669013
88Abnormal mitochondria in muscle tissue (HP:0008316)1.86488065
89Large eyes (HP:0001090)1.86248040
90Lipid accumulation in hepatocytes (HP:0006561)1.86165704
91Pancytopenia (HP:0001876)1.86096872
92Papilloma (HP:0012740)1.85704426
93Verrucae (HP:0200043)1.85704426
94Muscle stiffness (HP:0003552)1.85636977
95Hypochromic anemia (HP:0001931)1.85456961
96Carpal bone hypoplasia (HP:0001498)1.85158164
97Medulloblastoma (HP:0002885)1.84505536
98Abnormal umbilical cord blood vessels (HP:0011403)1.84378177
99Single umbilical artery (HP:0001195)1.84378177
100Abnormality of the fetal cardiovascular system (HP:0010948)1.84378177
101IgG deficiency (HP:0004315)1.83948313
102Mediastinal lymphadenopathy (HP:0100721)1.81789914
103Depressed nasal ridge (HP:0000457)1.81238663
104Fatigue (HP:0012378)1.79719191
105Abnormality of small intestinal villus morphology (HP:0011472)1.79310964
106Villous atrophy (HP:0011473)1.79310964
107Type I transferrin isoform profile (HP:0003642)1.79120675
108Patellar aplasia (HP:0006443)1.78962659
109Neoplasm of the pancreas (HP:0002894)1.78929268
110Chronic obstructive pulmonary disease (HP:0006510)1.75452089
111Obstructive lung disease (HP:0006536)1.75452089
112Inflammation of the large intestine (HP:0002037)1.75301114
113Increased serum pyruvate (HP:0003542)1.74949085
114Abnormalities of placenta or umbilical cord (HP:0001194)1.74305919
115Premature graying of hair (HP:0002216)1.73959054
116Pulmonary fibrosis (HP:0002206)1.72785516
117Cellular immunodeficiency (HP:0005374)1.72376294
118Granulocytopenia (HP:0001913)1.72061406
119Aplasia/Hypoplasia of the thymus (HP:0010515)1.71824409
120Skin ulcer (HP:0200042)1.71572698
121Bone marrow hypocellularity (HP:0005528)1.71520964
122Hepatic necrosis (HP:0002605)1.70980765
123Abnormal platelet function (HP:0011869)1.70644806
124Impaired platelet aggregation (HP:0003540)1.70644806
125Autoimmune thrombocytopenia (HP:0001973)1.70365465
126Aplasia/Hypoplasia of the patella (HP:0006498)1.69631475
127Mitochondrial inheritance (HP:0001427)1.69575506
128Glossoptosis (HP:0000162)1.69436361
129Abnormality of the heme biosynthetic pathway (HP:0010472)1.69400550
130Squamous cell carcinoma (HP:0002860)1.69306891
131Nasolacrimal duct obstruction (HP:0000579)1.69305982
132Abnormal number of incisors (HP:0011064)1.69053080
133Chromosomal breakage induced by crosslinking agents (HP:0003221)1.68851492
134Acute encephalopathy (HP:0006846)1.68738715
135Calcaneovalgus deformity (HP:0001848)1.68733312
136Hyperacusis (HP:0010780)1.68417707
137Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.67043676
138Decreased activity of mitochondrial respiratory chain (HP:0008972)1.67043676
139Cleft eyelid (HP:0000625)1.66410707
140Abnormality of the preputium (HP:0100587)1.66157317
141Gastrointestinal infarctions (HP:0005244)1.65052437
142Acute necrotizing encephalopathy (HP:0006965)1.64570403
143Combined immunodeficiency (HP:0005387)1.64176620
144Entropion (HP:0000621)1.64157952
145Reduced antithrombin III activity (HP:0001976)1.63123319
146Spontaneous hematomas (HP:0007420)1.62840282
147IgA deficiency (HP:0002720)1.62229016
148Epistaxis (HP:0000421)1.62148263
149Gout (HP:0001997)1.61726115
150Poor head control (HP:0002421)1.61565283
151Abnormal trabecular bone morphology (HP:0100671)1.60868568
152Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.60714464
153Partial duplication of thumb phalanx (HP:0009944)1.60708867
154Viral hepatitis (HP:0006562)1.59631416
155Abnormality of the calcaneus (HP:0008364)1.59201652
156Migraine (HP:0002076)1.58265479
157Atresia of the external auditory canal (HP:0000413)1.56969370
158Secondary amenorrhea (HP:0000869)1.56759212
159Increased serum lactate (HP:0002151)1.55315873
160Increased CSF lactate (HP:0002490)1.54091371
161Polygenic inheritance (HP:0010982)1.54077778
162Delayed cranial suture closure (HP:0000270)1.53458153
163Abnormality of placental membranes (HP:0011409)1.53235533
164Amniotic constriction ring (HP:0009775)1.53235533
165Acute lymphatic leukemia (HP:0006721)1.53218777
166Abnormal hemoglobin (HP:0011902)1.52743680

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.27238273
2SMG13.89634094
3NME23.68029771
4EEF2K3.51349289
5MAP4K13.32362855
6PRPF4B2.77192243
7BUB12.54274207
8MAP3K102.51467537
9WEE12.45930352
10CDC72.36053838
11PKN22.29942993
12RPS6KA42.08730835
13PIM22.08580134
14NEK22.06298058
15LRRK21.98867361
16PBK1.97533280
17RPS6KB21.92372299
18TRIB31.86086376
19TSSK61.69953404
20EIF2AK11.68920356
21TGFBR11.68510291
22ZAP701.60646647
23PASK1.60194753
24ACVR1B1.58839531
25BTK1.58304431
26STK101.55345078
27ERN11.53836304
28TLK11.51579660
29TAF11.39699295
30FLT31.38047071
31SCYL21.35085762
32IRAK31.34152560
33MAP2K31.33727365
34EIF2AK31.33285640
35ICK1.32385546
36JAK31.32206130
37STK161.31267156
38KDR1.29441986
39CDK41.27944093
40TYK21.27012424
41DYRK31.25673741
42TEC1.25328118
43VRK11.24370639
44CDK71.22913480
45NME11.22633065
46SIK11.22439351
47AURKB1.21778674
48SRPK11.18657276
49KIT1.18147317
50PIM11.17235776
51BLK1.16711435
52TBK11.16641333
53TESK21.15657052
54GRK61.10237402
55MAP3K111.09804863
56MKNK11.09557305
57PAK41.08696234
58ATR1.08052155
59MAP3K81.08026528
60MAPKAPK31.06931671
61ARAF1.06625221
62TXK1.05892349
63ILK1.04193267
64BRSK21.01617935
65CSF1R0.92889427
66IRAK40.92679094
67SYK0.90710028
68CHEK20.89718112
69BRAF0.87426423
70PLK10.85423112
71CDK120.84911765
72FGFR40.84367393
73MAP3K130.81202662
74IKBKB0.79961261
75NEK10.78803205
76IKBKE0.78452149
77MST40.78225128
78CLK10.77606065
79STK40.76931663
80TESK10.75762498
81TTK0.71065187
82ITK0.68671336
83MAP3K30.67673621
84MAP2K20.65216350
85CDK60.62323849
86MKNK20.61338961
87DAPK30.61226736
88CHEK10.60017145
89LYN0.58445028
90LCK0.58210685
91EPHA20.56326003
92CDK80.56218772
93CDK190.56060910
94RPS6KA60.55624401
95NLK0.54740065
96RPS6KA50.54617533
97DAPK10.53928826
98BRSK10.51997764
99CSNK2A20.50773772
100RPS6KC10.50127643
101RPS6KL10.50127643
102CDK90.50116844
103PAK10.49712427
104BRD40.48948551
105AURKA0.47556903
106PTK60.47534522
107ALK0.46769091
108CSNK2A10.46151196
109TGFBR20.45967381
110AKT20.45600049
111CHUK0.45539454
112MAPK110.45275695
113RIPK40.44909923
114MTOR0.44228402
115CCNB10.43821158
116MAPKAPK20.43258894
117HCK0.43195707
118MAP3K140.42739561
119TAOK20.41525554
120PLK40.40194453
121CDK20.39876447
122RPS6KA10.39767640
123PAK20.39700048
124BCKDK0.38933566
125IRAK20.35902126
126EIF2AK20.35089919
127MELK0.31298927
128RAF10.30524542
129KSR20.28934543

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030105.43717894
2DNA replication_Homo sapiens_hsa030304.47995630
3Mismatch repair_Homo sapiens_hsa034303.33750580
4Spliceosome_Homo sapiens_hsa030402.93475809
5Base excision repair_Homo sapiens_hsa034102.86842388
6Proteasome_Homo sapiens_hsa030502.78582723
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.45660449
8Nucleotide excision repair_Homo sapiens_hsa034202.31209630
9Homologous recombination_Homo sapiens_hsa034402.26139842
10RNA polymerase_Homo sapiens_hsa030202.25559127
11RNA transport_Homo sapiens_hsa030132.18419718
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.12058818
13Pyrimidine metabolism_Homo sapiens_hsa002402.07506778
14One carbon pool by folate_Homo sapiens_hsa006702.00155957
15Cell cycle_Homo sapiens_hsa041101.83826013
16Primary immunodeficiency_Homo sapiens_hsa053401.82370476
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73476641
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.67133165
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66555071
20Antigen processing and presentation_Homo sapiens_hsa046121.63110101
21Carbon metabolism_Homo sapiens_hsa012001.55306830
22RNA degradation_Homo sapiens_hsa030181.44762550
23Non-homologous end-joining_Homo sapiens_hsa034501.42741685
24Herpes simplex infection_Homo sapiens_hsa051681.41983693
25Oxidative phosphorylation_Homo sapiens_hsa001901.41283417
26Fanconi anemia pathway_Homo sapiens_hsa034601.34113252
27Fructose and mannose metabolism_Homo sapiens_hsa000511.29026742
28p53 signaling pathway_Homo sapiens_hsa041151.27440447
29Huntingtons disease_Homo sapiens_hsa050161.23685101
30Legionellosis_Homo sapiens_hsa051341.19521187
31Measles_Homo sapiens_hsa051621.19293223
32Epstein-Barr virus infection_Homo sapiens_hsa051691.18782658
33Leishmaniasis_Homo sapiens_hsa051401.16945489
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.10258365
35mRNA surveillance pathway_Homo sapiens_hsa030151.07673503
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.03297376
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03082786
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02548579
39Basal transcription factors_Homo sapiens_hsa030221.00935968
40Systemic lupus erythematosus_Homo sapiens_hsa053220.98477259
41Pyruvate metabolism_Homo sapiens_hsa006200.97673474
42Hematopoietic cell lineage_Homo sapiens_hsa046400.95384027
43Pentose phosphate pathway_Homo sapiens_hsa000300.95096018
44Apoptosis_Homo sapiens_hsa042100.92785727
45Central carbon metabolism in cancer_Homo sapiens_hsa052300.92114310
46Viral carcinogenesis_Homo sapiens_hsa052030.90997647
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89390863
48HTLV-I infection_Homo sapiens_hsa051660.88072652
49B cell receptor signaling pathway_Homo sapiens_hsa046620.87862118
50Purine metabolism_Homo sapiens_hsa002300.87452690
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.87312236
52Acute myeloid leukemia_Homo sapiens_hsa052210.86849539
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86584756
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86132514
55Shigellosis_Homo sapiens_hsa051310.85633534
56Sulfur relay system_Homo sapiens_hsa041220.84990443
57Protein export_Homo sapiens_hsa030600.82901977
58Hepatitis B_Homo sapiens_hsa051610.79234008
59Influenza A_Homo sapiens_hsa051640.77360599
60Alzheimers disease_Homo sapiens_hsa050100.76256429
61Chronic myeloid leukemia_Homo sapiens_hsa052200.75739861
62Thyroid cancer_Homo sapiens_hsa052160.75427641
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75067491
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73548389
65Small cell lung cancer_Homo sapiens_hsa052220.73315172
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73032069
67Folate biosynthesis_Homo sapiens_hsa007900.72487136
68N-Glycan biosynthesis_Homo sapiens_hsa005100.72386030
69Asthma_Homo sapiens_hsa053100.71785321
70Fatty acid elongation_Homo sapiens_hsa000620.70801958
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.70146834
72Toxoplasmosis_Homo sapiens_hsa051450.66985752
73Osteoclast differentiation_Homo sapiens_hsa043800.66266708
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65581470
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64747989
76Allograft rejection_Homo sapiens_hsa053300.64374043
77T cell receptor signaling pathway_Homo sapiens_hsa046600.64277756
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63824140
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58738287
80Viral myocarditis_Homo sapiens_hsa054160.58618162
81Autoimmune thyroid disease_Homo sapiens_hsa053200.56826674
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.55525186
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55340006
84Biosynthesis of amino acids_Homo sapiens_hsa012300.54435262
85Pertussis_Homo sapiens_hsa051330.51408212
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.50585295
87Graft-versus-host disease_Homo sapiens_hsa053320.50314080
88Selenocompound metabolism_Homo sapiens_hsa004500.50141828
89Notch signaling pathway_Homo sapiens_hsa043300.50115001
90Other glycan degradation_Homo sapiens_hsa005110.47345382
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46907333
92Colorectal cancer_Homo sapiens_hsa052100.46901428
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.46266676
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41979760
95TNF signaling pathway_Homo sapiens_hsa046680.41224947
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40487671
97MicroRNAs in cancer_Homo sapiens_hsa052060.40004461
98HIF-1 signaling pathway_Homo sapiens_hsa040660.39628611
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37600576
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37318713
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36708774
102Tuberculosis_Homo sapiens_hsa051520.36612832
103Non-small cell lung cancer_Homo sapiens_hsa052230.36588047
104Parkinsons disease_Homo sapiens_hsa050120.35921578
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35424025
106Glutathione metabolism_Homo sapiens_hsa004800.35108719
107Malaria_Homo sapiens_hsa051440.34871859
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34863071
109Platelet activation_Homo sapiens_hsa046110.34195343
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34142624
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34008307
112Pancreatic cancer_Homo sapiens_hsa052120.33051344
113Vitamin B6 metabolism_Homo sapiens_hsa007500.32763761
114Metabolic pathways_Homo sapiens_hsa011000.32214906
115Salmonella infection_Homo sapiens_hsa051320.31574056
116Prostate cancer_Homo sapiens_hsa052150.31512888
117Bladder cancer_Homo sapiens_hsa052190.30845849
118Galactose metabolism_Homo sapiens_hsa000520.30776783
119Vitamin digestion and absorption_Homo sapiens_hsa049770.30111016
120Endometrial cancer_Homo sapiens_hsa052130.29972039
121VEGF signaling pathway_Homo sapiens_hsa043700.27540157
122Arginine and proline metabolism_Homo sapiens_hsa003300.27521744
123Phenylalanine metabolism_Homo sapiens_hsa003600.25916515
124Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22902478
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20935346
126mTOR signaling pathway_Homo sapiens_hsa041500.20152412

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