

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of protein homooligomerization (GO:0032462) | 8.92504849 |
| 2 | T-helper 1 type immune response (GO:0042088) | 8.78044802 |
| 3 | protein targeting to peroxisome (GO:0006625) | 7.95281054 |
| 4 | establishment of protein localization to peroxisome (GO:0072663) | 7.95281054 |
| 5 | protein localization to peroxisome (GO:0072662) | 7.95281054 |
| 6 | lipopolysaccharide biosynthetic process (GO:0009103) | 7.53483733 |
| 7 | peroxisomal transport (GO:0043574) | 7.31775653 |
| 8 | histone H4-K12 acetylation (GO:0043983) | 7.20124153 |
| 9 | regulation of isotype switching to IgG isotypes (GO:0048302) | 6.96845904 |
| 10 | DNA deamination (GO:0045006) | 6.65662587 |
| 11 | lipopolysaccharide metabolic process (GO:0008653) | 6.59899377 |
| 12 | nucleotide transport (GO:0006862) | 6.15631534 |
| 13 | protein-cofactor linkage (GO:0018065) | 6.06920453 |
| 14 | rRNA catabolic process (GO:0016075) | 5.86977654 |
| 15 | positive regulation of isotype switching (GO:0045830) | 5.79256158 |
| 16 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.69880207 |
| 17 | negative regulation of glycogen biosynthetic process (GO:0045719) | 5.49204917 |
| 18 | intracellular protein transmembrane import (GO:0044743) | 5.42233314 |
| 19 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla | 5.29636661 |
| 20 | peroxisome organization (GO:0007031) | 5.24709390 |
| 21 | positive regulation of DNA recombination (GO:0045911) | 5.14617957 |
| 22 | spliceosomal snRNP assembly (GO:0000387) | 4.90003577 |
| 23 | DNA damage response, signal transduction resulting in transcription (GO:0042772) | 4.86022283 |
| 24 | antigen processing and presentation via MHC class Ib (GO:0002475) | 4.72098453 |
| 25 | positive regulation of interleukin-17 production (GO:0032740) | 4.67509793 |
| 26 | microtubule anchoring (GO:0034453) | 4.65180431 |
| 27 | regulation of telomere maintenance via telomerase (GO:0032210) | 4.61494908 |
| 28 | regulation of protein oligomerization (GO:0032459) | 4.40047393 |
| 29 | microglial cell activation (GO:0001774) | 4.37343834 |
| 30 | negative regulation of glycogen metabolic process (GO:0070874) | 4.37202140 |
| 31 | adaptation of signaling pathway (GO:0023058) | 4.35640175 |
| 32 | negative regulation of telomere maintenance (GO:0032205) | 4.31297187 |
| 33 | negative regulation of cell killing (GO:0031342) | 4.25568856 |
| 34 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 4.25568856 |
| 35 | intracellular protein transmembrane transport (GO:0065002) | 4.20284677 |
| 36 | regulation of energy homeostasis (GO:2000505) | 4.17667836 |
| 37 | extracellular regulation of signal transduction (GO:1900115) | 4.15738231 |
| 38 | extracellular negative regulation of signal transduction (GO:1900116) | 4.15738231 |
| 39 | RNA methylation (GO:0001510) | 4.12650213 |
| 40 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 4.03754764 |
| 41 | keratan sulfate biosynthetic process (GO:0018146) | 4.00348154 |
| 42 | lysine metabolic process (GO:0006553) | 3.95521568 |
| 43 | lysine catabolic process (GO:0006554) | 3.95521568 |
| 44 | macrophage chemotaxis (GO:0048246) | 3.89001251 |
| 45 | platelet dense granule organization (GO:0060155) | 3.77780703 |
| 46 | positive regulation of mast cell activation (GO:0033005) | 3.64569746 |
| 47 | RNA capping (GO:0036260) | 3.57672120 |
| 48 | 7-methylguanosine RNA capping (GO:0009452) | 3.57672120 |
| 49 | positive regulation of mast cell degranulation (GO:0043306) | 3.56928101 |
| 50 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 3.56928101 |
| 51 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.55943767 |
| 52 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.53959194 |
| 53 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.51728782 |
| 54 | positive regulation of B cell mediated immunity (GO:0002714) | 3.51728782 |
| 55 | sleep (GO:0030431) | 3.48094864 |
| 56 | regulation of isotype switching (GO:0045191) | 3.46992830 |
| 57 | protein transmembrane transport (GO:0071806) | 3.45823757 |
| 58 | positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725) | 3.44213953 |
| 59 | macrophage activation involved in immune response (GO:0002281) | 3.39805943 |
| 60 | positive regulation of immunoglobulin production (GO:0002639) | 3.38553872 |
| 61 | histone H4-K5 acetylation (GO:0043981) | 3.38424854 |
| 62 | histone H4-K8 acetylation (GO:0043982) | 3.38424854 |
| 63 | cilium or flagellum-dependent cell motility (GO:0001539) | 3.33619534 |
| 64 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.33305081 |
| 65 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 3.32893397 |
| 66 | regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645) | 3.28000875 |
| 67 | nucleoside diphosphate phosphorylation (GO:0006165) | 3.26187215 |
| 68 | membrane docking (GO:0022406) | 3.22727763 |
| 69 | thrombin receptor signaling pathway (GO:0070493) | 3.12915890 |
| 70 | keratan sulfate metabolic process (GO:0042339) | 3.08789829 |
| 71 | ribosome assembly (GO:0042255) | 3.08764609 |
| 72 | negative regulation of telomerase activity (GO:0051974) | 3.08024487 |
| 73 | sulfation (GO:0051923) | 3.04373850 |
| 74 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.03823935 |
| 75 | ncRNA catabolic process (GO:0034661) | 3.00577828 |
| 76 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 2.90736461 |
| 77 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO | 2.89278125 |
| 78 | negative regulation of mast cell activation (GO:0033004) | 2.88959833 |
| 79 | glycerophospholipid catabolic process (GO:0046475) | 2.85728233 |
| 80 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 2.85386597 |
| 81 | positive regulation of leukocyte mediated immunity (GO:0002705) | 2.82054466 |
| 82 | ribonucleoprotein complex biogenesis (GO:0022613) | 2.80390748 |
| 83 | termination of RNA polymerase III transcription (GO:0006386) | 2.79103566 |
| 84 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.79103566 |
| 85 | cellular protein complex disassembly (GO:0043624) | 2.78649356 |
| 86 | positive regulation of lymphocyte mediated immunity (GO:0002708) | 2.71397527 |
| 87 | ribosomal small subunit assembly (GO:0000028) | 2.69507187 |
| 88 | positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357 | 2.68719910 |
| 89 | positive regulation of adaptive immune response based on somatic recombination of immune receptors b | 2.66339151 |
| 90 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 2.65707131 |
| 91 | regulation of natural killer cell mediated immunity (GO:0002715) | 2.65707131 |
| 92 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 2.65041830 |
| 93 | T-helper cell differentiation (GO:0042093) | 2.65041830 |
| 94 | aspartate family amino acid catabolic process (GO:0009068) | 2.64582664 |
| 95 | regulation of protein kinase A signaling (GO:0010738) | 2.61595265 |
| 96 | positive regulation vascular endothelial growth factor production (GO:0010575) | 2.61293711 |
| 97 | maturation of 5.8S rRNA (GO:0000460) | 15.8197312 |
| 98 | negative regulation of protein oligomerization (GO:0032460) | 12.4473934 |
| 99 | nucleotide transmembrane transport (GO:1901679) | 12.1826257 |
| 100 | protein import into peroxisome matrix (GO:0016558) | 11.6704795 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 6.35134057 |
| 2 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 5.99328195 |
| 3 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 4.53713913 |
| 4 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 3.81618637 |
| 5 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 3.56795544 |
| 6 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 3.34227661 |
| 7 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 3.08827762 |
| 8 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.89815211 |
| 9 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.85563844 |
| 10 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.85300058 |
| 11 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.68301092 |
| 12 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.54736470 |
| 13 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.53152578 |
| 14 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 2.51846119 |
| 15 | IRF1_19129219_ChIP-ChIP_H3396_Human | 2.38010906 |
| 16 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 2.24820382 |
| 17 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.94885477 |
| 18 | GATA1_22025678_ChIP-Seq_K562_Human | 1.93134573 |
| 19 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.92790870 |
| 20 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.90079678 |
| 21 | VDR_22108803_ChIP-Seq_LS180_Human | 1.89083686 |
| 22 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.88130309 |
| 23 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.82743225 |
| 24 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.78722768 |
| 25 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.78606011 |
| 26 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.74017130 |
| 27 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.72321807 |
| 28 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.71891423 |
| 29 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.65937847 |
| 30 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.62645897 |
| 31 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 1.56459827 |
| 32 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.51127869 |
| 33 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.48209929 |
| 34 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.48022734 |
| 35 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.44955363 |
| 36 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.42158455 |
| 37 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.41673078 |
| 38 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.41005873 |
| 39 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.40206105 |
| 40 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.37822681 |
| 41 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.36626449 |
| 42 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.36626449 |
| 43 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.30303154 |
| 44 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.30000974 |
| 45 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.26199105 |
| 46 | EWS_26573619_Chip-Seq_HEK293_Human | 1.25889672 |
| 47 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.24901663 |
| 48 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.24513140 |
| 49 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.23111867 |
| 50 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.23111867 |
| 51 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.22634452 |
| 52 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.21136095 |
| 53 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.20591653 |
| 54 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 1.17530346 |
| 55 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.16376918 |
| 56 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.11715028 |
| 57 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.08941487 |
| 58 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.08071547 |
| 59 | AR_20517297_ChIP-Seq_VCAP_Human | 1.07923036 |
| 60 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.06745635 |
| 61 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.05285577 |
| 62 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.03911786 |
| 63 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.02403957 |
| 64 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.02348589 |
| 65 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.01233000 |
| 66 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.01111640 |
| 67 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.00046408 |
| 68 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.98788683 |
| 69 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.96660895 |
| 70 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.95638388 |
| 71 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.94303695 |
| 72 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.92050013 |
| 73 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.91638539 |
| 74 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.91406899 |
| 75 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.90920733 |
| 76 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 0.90870446 |
| 77 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.90742956 |
| 78 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.90738785 |
| 79 | NCOR_22424771_ChIP-Seq_293T_Human | 0.90426109 |
| 80 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.90116671 |
| 81 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.89976123 |
| 82 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.88468515 |
| 83 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.86084132 |
| 84 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.84832689 |
| 85 | SOX2_21211035_ChIP-Seq_LN229_Human | 0.84505169 |
| 86 | SCL_19346495_ChIP-Seq_HPC-7_Human | 0.84272564 |
| 87 | GATA3_26560356_Chip-Seq_TH2_Human | 0.84129367 |
| 88 | AR_25329375_ChIP-Seq_VCAP_Human | 0.83884219 |
| 89 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.83521775 |
| 90 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.83096857 |
| 91 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 0.82562272 |
| 92 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.82516612 |
| 93 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 0.81936733 |
| 94 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.81108592 |
| 95 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.80890417 |
| 96 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.80161758 |
| 97 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.79908135 |
| 98 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.79626895 |
| 99 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 0.79169497 |
| 100 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.76852630 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0006082_CNS_inflammation | 9.49743538 |
| 2 | MP0001873_stomach_inflammation | 4.93406363 |
| 3 | MP0001348_abnormal_lacrimal_gland | 4.66576642 |
| 4 | MP0002132_abnormal_respiratory_system | 4.01763228 |
| 5 | MP0001346_abnormal_lacrimal_gland | 3.95380709 |
| 6 | MP0002876_abnormal_thyroid_physiology | 3.53099129 |
| 7 | MP0003300_gastrointestinal_ulcer | 3.29852966 |
| 8 | MP0003690_abnormal_glial_cell | 3.12818942 |
| 9 | MP0002837_dystrophic_cardiac_calcinosis | 2.57954384 |
| 10 | MP0005671_abnormal_response_to | 2.28877698 |
| 11 | MP0009333_abnormal_splenocyte_physiolog | 2.03859485 |
| 12 | MP0002254_reproductive_system_inflammat | 10.2469368 |
| 13 | MP0003693_abnormal_embryo_hatching | 1.90127829 |
| 14 | MP0005310_abnormal_salivary_gland | 1.76984295 |
| 15 | MP0003950_abnormal_plasma_membrane | 1.72083838 |
| 16 | MP0002405_respiratory_system_inflammati | 1.55366514 |
| 17 | MP0005647_abnormal_sex_gland | 1.54697514 |
| 18 | MP0000685_abnormal_immune_system | 1.53445254 |
| 19 | MP0001984_abnormal_olfaction | 1.51329635 |
| 20 | MP0002277_abnormal_respiratory_mucosa | 1.47548812 |
| 21 | MP0000613_abnormal_salivary_gland | 1.44010330 |
| 22 | MP0003763_abnormal_thymus_physiology | 1.43663614 |
| 23 | MP0001663_abnormal_digestive_system | 1.24634717 |
| 24 | MP0005595_abnormal_vascular_smooth | 1.18929299 |
| 25 | MP0009785_altered_susceptibility_to | 1.16590300 |
| 26 | MP0001919_abnormal_reproductive_system | 1.11137603 |
| 27 | MP0005000_abnormal_immune_tolerance | 1.08367893 |
| 28 | MP0000920_abnormal_myelination | 1.02269224 |
| 29 | MP0006292_abnormal_olfactory_placode | 1.00730252 |
| 30 | MP0001915_intracranial_hemorrhage | 0.97404308 |
| 31 | MP0005166_decreased_susceptibility_to | 0.95802029 |
| 32 | MP0005389_reproductive_system_phenotype | 0.93712022 |
| 33 | MP0009046_muscle_twitch | 0.90614719 |
| 34 | MP0000858_altered_metastatic_potential | 0.90534191 |
| 35 | MP0010155_abnormal_intestine_physiology | 0.89303538 |
| 36 | MP0005197_abnormal_uvea_morphology | 0.88844782 |
| 37 | MP0001800_abnormal_humoral_immune | 0.88833667 |
| 38 | MP0001851_eye_inflammation | 0.87783095 |
| 39 | MP0004885_abnormal_endolymph | 0.87502523 |
| 40 | MP0003724_increased_susceptibility_to | 0.87369336 |
| 41 | MP0000631_abnormal_neuroendocrine_gland | 0.85888252 |
| 42 | MP0005381_digestive/alimentary_phenotyp | 0.85293484 |
| 43 | MP0005025_abnormal_response_to | 0.81767376 |
| 44 | MP0002163_abnormal_gland_morphology | 0.79779949 |
| 45 | MP0002693_abnormal_pancreas_physiology | 0.79425998 |
| 46 | MP0005645_abnormal_hypothalamus_physiol | 0.78869393 |
| 47 | MP0001119_abnormal_female_reproductive | 0.78119927 |
| 48 | MP0005448_abnormal_energy_balance | 0.77214853 |
| 49 | MP0001790_abnormal_immune_system | 0.76413764 |
| 50 | MP0005387_immune_system_phenotype | 0.76413764 |
| 51 | MP0003718_maternal_effect | 0.75057413 |
| 52 | MP0002138_abnormal_hepatobiliary_system | 0.75053369 |
| 53 | MP0002452_abnormal_antigen_presenting | 0.72663955 |
| 54 | MP0004883_abnormal_blood_vessel | 0.69983295 |
| 55 | MP0005167_abnormal_blood-brain_barrier | 0.69700832 |
| 56 | MP0000703_abnormal_thymus_morphology | 0.68602393 |
| 57 | MP0002420_abnormal_adaptive_immunity | 0.67976069 |
| 58 | MP0001819_abnormal_immune_cell | 0.65806746 |
| 59 | MP0002723_abnormal_immune_serum | 0.65138652 |
| 60 | MP0009765_abnormal_xenobiotic_induced | 0.64600842 |
| 61 | MP0003786_premature_aging | 0.62579554 |
| 62 | MP0002419_abnormal_innate_immunity | 0.62158000 |
| 63 | MP0003011_delayed_dark_adaptation | 0.59553827 |
| 64 | MP0000470_abnormal_stomach_morphology | 0.57696111 |
| 65 | MP0000465_gastrointestinal_hemorrhage | 0.57260790 |
| 66 | MP0000639_abnormal_adrenal_gland | 0.56274950 |
| 67 | MP0003183_abnormal_peptide_metabolism | 0.56270805 |
| 68 | MP0002102_abnormal_ear_morphology | 0.55513785 |
| 69 | MP0005646_abnormal_pituitary_gland | 0.54697162 |
| 70 | MP0002229_neurodegeneration | 0.53285681 |
| 71 | MP0009763_increased_sensitivity_to | 0.52494254 |
| 72 | MP0000716_abnormal_immune_system | 0.51923583 |
| 73 | MP0001501_abnormal_sleep_pattern | 0.51108190 |
| 74 | MP0001835_abnormal_antigen_presentation | 0.50224852 |
| 75 | MP0005164_abnormal_response_to | 0.48940120 |
| 76 | MP0000230_abnormal_systemic_arterial | 0.48203334 |
| 77 | MP0008877_abnormal_DNA_methylation | 0.47141295 |
| 78 | MP0008469_abnormal_protein_level | 0.46427834 |
| 79 | MP0003699_abnormal_female_reproductive | 0.46052494 |
| 80 | MP0003448_altered_tumor_morphology | 0.45604707 |
| 81 | MP0006072_abnormal_retinal_apoptosis | 0.45253394 |
| 82 | MP0003195_calcinosis | 0.43811218 |
| 83 | MP0005023_abnormal_wound_healing | 0.43786119 |
| 84 | MP0001845_abnormal_inflammatory_respons | 0.43255958 |
| 85 | MP0005379_endocrine/exocrine_gland_phen | 0.42816866 |
| 86 | MP0002160_abnormal_reproductive_system | 0.40037414 |
| 87 | MP0003866_abnormal_defecation | 0.39578517 |
| 88 | MP0000477_abnormal_intestine_morphology | 0.38889283 |
| 89 | MP0001986_abnormal_taste_sensitivity | 0.38127943 |
| 90 | MP0010329_abnormal_lipoprotein_level | 0.37613607 |
| 91 | MP0005376_homeostasis/metabolism_phenot | 0.37529440 |
| 92 | MP0005410_abnormal_fertilization | 0.37497814 |
| 93 | MP0003698_abnormal_male_reproductive | 0.37466402 |
| 94 | MP0003646_muscle_fatigue | 0.36431801 |
| 95 | MP0004085_abnormal_heartbeat | 0.35456738 |
| 96 | MP0001944_abnormal_pancreas_morphology | 0.35381867 |
| 97 | MP0002272_abnormal_nervous_system | 0.35173080 |
| 98 | MP0002429_abnormal_blood_cell | 0.34764296 |
| 99 | MP0003283_abnormal_digestive_organ | 0.34212721 |
| 100 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.33727286 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Brushfield spots (HP:0001088) | 9.48338991 |
| 2 | Delayed closure of the anterior fontanelle (HP:0001476) | 7.82615981 |
| 3 | Flat occiput (HP:0005469) | 7.73092156 |
| 4 | Autoimmune thrombocytopenia (HP:0001973) | 5.79246984 |
| 5 | Asplenia (HP:0001746) | 5.50154608 |
| 6 | Nasal polyposis (HP:0100582) | 5.43913982 |
| 7 | Stomatitis (HP:0010280) | 5.32433117 |
| 8 | Chronic mucocutaneous candidiasis (HP:0002728) | 5.30457479 |
| 9 | Recurrent cutaneous fungal infections (HP:0011370) | 5.30457479 |
| 10 | Abnormality of B cell number (HP:0010975) | 5.28294530 |
| 11 | Epiphyseal stippling (HP:0010655) | 5.19426417 |
| 12 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 5.17920984 |
| 13 | Primary adrenal insufficiency (HP:0008207) | 4.78120644 |
| 14 | Abnormality of the nasal mucosa (HP:0000433) | 4.50180468 |
| 15 | Aplastic anemia (HP:0001915) | 4.33817773 |
| 16 | Keratoconjunctivitis (HP:0001096) | 4.29793636 |
| 17 | Posterior embryotoxon (HP:0000627) | 4.25359138 |
| 18 | Female pseudohermaphroditism (HP:0010458) | 4.22637083 |
| 19 | Abnormality of the line of Schwalbe (HP:0008048) | 4.15475521 |
| 20 | Thickened nuchal skin fold (HP:0000474) | 4.03797070 |
| 21 | Recurrent fungal infections (HP:0002841) | 3.88876224 |
| 22 | Oral leukoplakia (HP:0002745) | 3.88625241 |
| 23 | Methylmalonic acidemia (HP:0002912) | 3.71801826 |
| 24 | Abnormal epiphyseal ossification (HP:0010656) | 3.71730812 |
| 25 | Abnormality of calcium-phosphate metabolism (HP:0100530) | 3.68741110 |
| 26 | Increased IgM level (HP:0003496) | 3.64784560 |
| 27 | Stomach cancer (HP:0012126) | 3.57283292 |
| 28 | Pustule (HP:0200039) | 3.55960491 |
| 29 | Delayed cranial suture closure (HP:0000270) | 3.44451189 |
| 30 | Autoimmune hemolytic anemia (HP:0001890) | 3.43209166 |
| 31 | Abnormality of homocysteine metabolism (HP:0010919) | 3.33692269 |
| 32 | Homocystinuria (HP:0002156) | 3.33692269 |
| 33 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.28417707 |
| 34 | Abnormality of T cell physiology (HP:0011840) | 3.28348331 |
| 35 | Type I diabetes mellitus (HP:0100651) | 3.19960530 |
| 36 | Alopecia of scalp (HP:0002293) | 2.94218378 |
| 37 | Abnormality of methionine metabolism (HP:0010901) | 2.86884355 |
| 38 | Polydipsia (HP:0001959) | 2.79172899 |
| 39 | Abnormal drinking behavior (HP:0030082) | 2.79172899 |
| 40 | Underdeveloped supraorbital ridges (HP:0009891) | 2.76897468 |
| 41 | Chronic diarrhea (HP:0002028) | 2.76234469 |
| 42 | Hypercortisolism (HP:0001578) | 2.72651531 |
| 43 | Agammaglobulinemia (HP:0004432) | 2.72206212 |
| 44 | Methylmalonic aciduria (HP:0012120) | 2.68312716 |
| 45 | Abnormality of T cells (HP:0002843) | 2.53853817 |
| 46 | Respiratory distress (HP:0002098) | 2.50502925 |
| 47 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.47575628 |
| 48 | Pyloric stenosis (HP:0002021) | 2.44519523 |
| 49 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.42290524 |
| 50 | Hypomagnesemia (HP:0002917) | 2.39024349 |
| 51 | Hypoparathyroidism (HP:0000829) | 2.37953019 |
| 52 | Megaloblastic anemia (HP:0001889) | 2.36512121 |
| 53 | Pancytopenia (HP:0001876) | 2.35003427 |
| 54 | Eosinophilia (HP:0001880) | 2.34964518 |
| 55 | Abnormality of vitamin B metabolism (HP:0004340) | 2.33025182 |
| 56 | Neutropenia (HP:0001875) | 2.32150277 |
| 57 | Tetany (HP:0001281) | 2.29077366 |
| 58 | Type II lissencephaly (HP:0007260) | 2.20755244 |
| 59 | Increased IgE level (HP:0003212) | 2.18651691 |
| 60 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.18317993 |
| 61 | Spinal cord lesions (HP:0100561) | 2.18287846 |
| 62 | Syringomyelia (HP:0003396) | 2.18287846 |
| 63 | Conical tooth (HP:0000698) | 2.16929358 |
| 64 | Pendular nystagmus (HP:0012043) | 2.12289959 |
| 65 | Hypergammaglobulinemia (HP:0010702) | 2.09768349 |
| 66 | B lymphocytopenia (HP:0010976) | 2.09355080 |
| 67 | External ear malformation (HP:0008572) | 2.09149438 |
| 68 | Polyuria (HP:0000103) | 2.06524130 |
| 69 | Keratitis (HP:0000491) | 1.97701615 |
| 70 | Hypochromic anemia (HP:0001931) | 1.95576099 |
| 71 | Cholelithiasis (HP:0001081) | 1.94211190 |
| 72 | Cerebellar dysplasia (HP:0007033) | 1.92209880 |
| 73 | Abnormality of eosinophils (HP:0001879) | 1.91509345 |
| 74 | Short tibia (HP:0005736) | 1.91093513 |
| 75 | Abnormality of T cell number (HP:0011839) | 1.90776657 |
| 76 | Type 2 muscle fiber atrophy (HP:0003554) | 1.88353867 |
| 77 | Polyphagia (HP:0002591) | 1.85214409 |
| 78 | Recurrent skin infections (HP:0001581) | 1.83647335 |
| 79 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.83376689 |
| 80 | Glycosuria (HP:0003076) | 1.82378717 |
| 81 | Abnormality of urine glucose concentration (HP:0011016) | 1.82378717 |
| 82 | Premature birth (HP:0001622) | 1.80011294 |
| 83 | Hypoproteinemia (HP:0003075) | 1.79826873 |
| 84 | Abnormality of the pons (HP:0007361) | 1.78797175 |
| 85 | Pulmonary fibrosis (HP:0002206) | 1.77248379 |
| 86 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.76723591 |
| 87 | Abnormal gallbladder morphology (HP:0012437) | 1.76605694 |
| 88 | Abnormality of magnesium homeostasis (HP:0004921) | 1.75512812 |
| 89 | Granulocytopenia (HP:0001913) | 1.73355507 |
| 90 | Abnormal urine output (HP:0012590) | 1.72190976 |
| 91 | Fibular aplasia (HP:0002990) | 1.69931082 |
| 92 | Thyroid-stimulating hormone excess (HP:0002925) | 1.68438509 |
| 93 | Hypoplasia of the pons (HP:0012110) | 1.67656045 |
| 94 | Increased CSF lactate (HP:0002490) | 1.67095198 |
| 95 | Hepatocellular necrosis (HP:0001404) | 1.67038723 |
| 96 | Cheilitis (HP:0100825) | 1.63456363 |
| 97 | Adrenal overactivity (HP:0002717) | 1.61459478 |
| 98 | Lymphopenia (HP:0001888) | 1.61109186 |
| 99 | Furrowed tongue (HP:0000221) | 1.61027420 |
| 100 | Congenital stationary night blindness (HP:0007642) | 1.58231247 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PASK | 9.99037803 |
| 2 | MAP3K13 | 8.14374142 |
| 3 | MAP3K14 | 3.99453327 |
| 4 | CAMKK1 | 3.66995734 |
| 5 | ITK | 3.20215290 |
| 6 | FGR | 2.89836816 |
| 7 | MAP3K12 | 1.77863496 |
| 8 | BMPR1B | 1.67249201 |
| 9 | TXK | 1.52778910 |
| 10 | MAP3K7 | 1.39802632 |
| 11 | IKBKB | 1.39429414 |
| 12 | PKN1 | 1.38703496 |
| 13 | ADRBK2 | 1.36779681 |
| 14 | CSK | 1.33669487 |
| 15 | MST4 | 1.22368336 |
| 16 | GRK1 | 1.09380276 |
| 17 | ZAK | 1.05649495 |
| 18 | FGFR1 | 1.03862497 |
| 19 | TAOK3 | 1.02657781 |
| 20 | TESK2 | 1.02006782 |
| 21 | GSK3A | 0.89551455 |
| 22 | MAP4K2 | 0.86399937 |
| 23 | TYK2 | 0.86089751 |
| 24 | BCKDK | 0.85067471 |
| 25 | NUAK1 | 0.84297468 |
| 26 | TIE1 | 0.83046406 |
| 27 | JAK1 | 0.80340075 |
| 28 | KDR | 0.77819192 |
| 29 | NEK9 | 0.77516223 |
| 30 | PBK | 0.75613164 |
| 31 | MAP4K1 | 0.74925867 |
| 32 | FRK | 0.74437675 |
| 33 | KIT | 0.72590148 |
| 34 | STK10 | 0.70869875 |
| 35 | VRK2 | 0.70637639 |
| 36 | PRKCQ | 0.69313528 |
| 37 | MAPK7 | 0.67309138 |
| 38 | PIK3CG | 0.64653051 |
| 39 | WNK4 | 0.62971751 |
| 40 | CHUK | 0.58530542 |
| 41 | EIF2AK3 | 0.57949529 |
| 42 | PLK4 | 0.54461775 |
| 43 | TSSK6 | 0.52724239 |
| 44 | TLK1 | 0.52306190 |
| 45 | WNK3 | 0.50709210 |
| 46 | TGFBR1 | 0.50106994 |
| 47 | INSRR | 0.49448850 |
| 48 | MUSK | 0.47916832 |
| 49 | SYK | 0.47390064 |
| 50 | ALK | 0.46956313 |
| 51 | CHEK2 | 0.46114858 |
| 52 | STK16 | 0.45796196 |
| 53 | BTK | 0.45763958 |
| 54 | LYN | 0.45581156 |
| 55 | PRKG2 | 0.40170514 |
| 56 | VRK1 | 0.39349327 |
| 57 | NME2 | 0.38886537 |
| 58 | STK39 | 0.38434963 |
| 59 | PLK1 | 0.37843014 |
| 60 | AURKA | 0.36963127 |
| 61 | CSNK1A1 | 0.36885290 |
| 62 | CSNK1G3 | 0.36739593 |
| 63 | PRKAA2 | 0.34881978 |
| 64 | CDK8 | 0.34663257 |
| 65 | BUB1 | 0.33914139 |
| 66 | LCK | 0.33415643 |
| 67 | TEC | 0.33206421 |
| 68 | CDK4 | 0.32597899 |
| 69 | CSNK1G1 | 0.32217692 |
| 70 | OBSCN | 0.31644952 |
| 71 | OXSR1 | 0.29931231 |
| 72 | LRRK2 | 0.29227428 |
| 73 | MAPK13 | 0.26796758 |
| 74 | RPS6KA4 | 0.26037089 |
| 75 | FYN | 0.26004096 |
| 76 | ABL1 | 0.25878942 |
| 77 | GRK7 | 0.25507408 |
| 78 | MAPK12 | 0.24801019 |
| 79 | CSNK1G2 | 0.24769126 |
| 80 | EIF2AK2 | 0.23821888 |
| 81 | CSNK1A1L | 0.23048170 |
| 82 | ADRBK1 | 0.22114461 |
| 83 | EIF2AK1 | 0.21584716 |
| 84 | IKBKE | 0.21164729 |
| 85 | RPS6KA5 | 0.20989111 |
| 86 | FLT3 | 0.20261844 |
| 87 | PINK1 | 0.18578416 |
| 88 | CCNB1 | 0.18381668 |
| 89 | CDC7 | 0.17863698 |
| 90 | PIM1 | 0.17470221 |
| 91 | PRKCA | 0.16528147 |
| 92 | PRKACA | 0.16299615 |
| 93 | PLK3 | 0.15777504 |
| 94 | BMPR2 | 0.13775552 |
| 95 | JAK2 | 0.13755119 |
| 96 | MAPK1 | 0.12720151 |
| 97 | MKNK1 | 0.12595533 |
| 98 | MAP3K11 | 0.12584590 |
| 99 | PHKG1 | 0.12440299 |
| 100 | PHKG2 | 0.12440299 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 3.94378413 |
| 2 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 3.60338435 |
| 3 | Allograft rejection_Homo sapiens_hsa05330 | 3.59912283 |
| 4 | Graft-versus-host disease_Homo sapiens_hsa05332 | 3.24367610 |
| 5 | Ribosome_Homo sapiens_hsa03010 | 3.20949773 |
| 6 | Primary immunodeficiency_Homo sapiens_hsa05340 | 3.20102974 |
| 7 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.98223143 |
| 8 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.66734541 |
| 9 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.55927027 |
| 10 | RNA degradation_Homo sapiens_hsa03018 | 2.38145632 |
| 11 | Parkinsons disease_Homo sapiens_hsa05012 | 2.37175311 |
| 12 | RNA polymerase_Homo sapiens_hsa03020 | 2.21681950 |
| 13 | Peroxisome_Homo sapiens_hsa04146 | 2.17383571 |
| 14 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.07636160 |
| 15 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.06779603 |
| 16 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.00537858 |
| 17 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.99909915 |
| 18 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.83064465 |
| 19 | Asthma_Homo sapiens_hsa05310 | 1.73609762 |
| 20 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.68262481 |
| 21 | Huntingtons disease_Homo sapiens_hsa05016 | 1.65535445 |
| 22 | Alzheimers disease_Homo sapiens_hsa05010 | 1.65396414 |
| 23 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.49419644 |
| 24 | Proteasome_Homo sapiens_hsa03050 | 1.49080146 |
| 25 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.45292600 |
| 26 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.41630489 |
| 27 | RNA transport_Homo sapiens_hsa03013 | 1.41477593 |
| 28 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.30923661 |
| 29 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.30545214 |
| 30 | Mineral absorption_Homo sapiens_hsa04978 | 1.27179608 |
| 31 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.24153868 |
| 32 | Retinol metabolism_Homo sapiens_hsa00830 | 1.16250160 |
| 33 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.15894004 |
| 34 | Viral myocarditis_Homo sapiens_hsa05416 | 1.14336894 |
| 35 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.09146679 |
| 36 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.09039718 |
| 37 | Purine metabolism_Homo sapiens_hsa00230 | 1.04716473 |
| 38 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.04691162 |
| 39 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.03872522 |
| 40 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.97598493 |
| 41 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.96271011 |
| 42 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.90364327 |
| 43 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.85269490 |
| 44 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.84184449 |
| 45 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.82043207 |
| 46 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.80805756 |
| 47 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.79752632 |
| 48 | Legionellosis_Homo sapiens_hsa05134 | 0.77948115 |
| 49 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.77000504 |
| 50 | Malaria_Homo sapiens_hsa05144 | 0.76557356 |
| 51 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.75672916 |
| 52 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.73714506 |
| 53 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.73126401 |
| 54 | Phototransduction_Homo sapiens_hsa04744 | 0.71427048 |
| 55 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.71113392 |
| 56 | DNA replication_Homo sapiens_hsa03030 | 0.70725597 |
| 57 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.70246761 |
| 58 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.70173157 |
| 59 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.69458181 |
| 60 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.68369597 |
| 61 | Homologous recombination_Homo sapiens_hsa03440 | 0.68138702 |
| 62 | Sulfur relay system_Homo sapiens_hsa04122 | 0.67560051 |
| 63 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.65098828 |
| 64 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.64633920 |
| 65 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.64399619 |
| 66 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.62161343 |
| 67 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.60388251 |
| 68 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.59245245 |
| 69 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.55650998 |
| 70 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.54167569 |
| 71 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.51787689 |
| 72 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.49017978 |
| 73 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.48400245 |
| 74 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.47014140 |
| 75 | Protein export_Homo sapiens_hsa03060 | 0.47005438 |
| 76 | Spliceosome_Homo sapiens_hsa03040 | 0.42379629 |
| 77 | Mismatch repair_Homo sapiens_hsa03430 | 0.40682642 |
| 78 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.40155215 |
| 79 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.38518519 |
| 80 | Metabolic pathways_Homo sapiens_hsa01100 | 0.37305033 |
| 81 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.36052381 |
| 82 | Taste transduction_Homo sapiens_hsa04742 | 0.34434770 |
| 83 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.33518113 |
| 84 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.32850145 |
| 85 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.31615211 |
| 86 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.31355260 |
| 87 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.29346607 |
| 88 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.28801799 |
| 89 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.28519850 |
| 90 | Olfactory transduction_Homo sapiens_hsa04740 | 0.27603085 |
| 91 | HTLV-I infection_Homo sapiens_hsa05166 | 0.24762993 |
| 92 | Tuberculosis_Homo sapiens_hsa05152 | 0.21675657 |
| 93 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.21257891 |
| 94 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.21085045 |
| 95 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.20071487 |
| 96 | Circadian rhythm_Homo sapiens_hsa04710 | 0.19039735 |
| 97 | Leishmaniasis_Homo sapiens_hsa05140 | 0.18194452 |
| 98 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.18104800 |
| 99 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.17202761 |
| 100 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.16462429 |

