ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cytidine deamination (GO:0009972)	6.92508362
2	cytidine metabolic process (GO:0046087)	6.92508362
3	cytidine catabolic process (GO:0006216)	6.92508362
4	DNA deamination (GO:0045006)	6.54254837
5	pyrimidine ribonucleoside catabolic process (GO:0046133)	5.90711788
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.71490095
7	maturation of SSU-rRNA (GO:0030490)	4.34817163
8	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.29142015
9	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.25592219
10	positive T cell selection (GO:0043368)	4.23699262
11	positive regulation of interleukin-8 secretion (GO:2000484)	4.22756311
12	T cell migration (GO:0072678)	4.22612089
13	positive regulation of B cell differentiation (GO:0045579)	4.15980660
14	negative T cell selection (GO:0043383)	4.10585345
15	regulation of B cell receptor signaling pathway (GO:0050855)	4.03141337
16	positive thymic T cell selection (GO:0045059)	4.01981177
17	ribosomal small subunit assembly (GO:0000028)	3.97980842
18	regulation of regulatory T cell differentiation (GO:0045589)	3.97339847
19	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.83866049
20	negative regulation of T cell apoptotic process (GO:0070233)	3.74917424
21	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.67827522
22	respiratory electron transport chain (GO:0022904)	3.66085135
23	electron transport chain (GO:0022900)	3.63161310
24	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.61452555
25	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.61452555
26	regulation of interleukin-8 secretion (GO:2000482)	3.58724914
27	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.56888535
28	ATP synthesis coupled proton transport (GO:0015986)	3.56888535
29	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.54669212
30	actin nucleation (GO:0045010)	3.35272284
31	viral transcription (GO:0019083)	3.32305512
32	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.30156971
33	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.26509237
34	regulation of cellular amino acid metabolic process (GO:0006521)	3.24007485
35	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.19841387
36	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.18185946
37	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.18185946
38	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.18185946
39	translational termination (GO:0006415)	3.17276782
40	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.16772659
41	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.16772659
42	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.15352748
43	thymic T cell selection (GO:0045061)	3.15043499
44	negative regulation of B cell proliferation (GO:0030889)	3.14783123
45	regulation of activation of Janus kinase activity (GO:0010533)	3.13653941
46	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.13420690
47	regulation of T cell receptor signaling pathway (GO:0050856)	3.10712926
48	regulation of B cell differentiation (GO:0045577)	3.08088548
49	pyrimidine nucleoside catabolic process (GO:0046135)	3.07478570
50	translational elongation (GO:0006414)	3.07361965
51	positive regulation of defense response to virus by host (GO:0002230)	3.06334635
52	T cell selection (GO:0045058)	3.05684390
53	regulation of gamma-delta T cell differentiation (GO:0045586)	3.03566322
54	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.02975261
55	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.02645923
56	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.02645923
57	DNA demethylation (GO:0080111)	3.02626101
58	response to interferon-beta (GO:0035456)	3.01213537
59	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.00766039
60	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.99330183
61	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.98881845
62	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.97297994
63	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.96558950
64	positive regulation of gamma-delta T cell activation (GO:0046645)	2.95731457
65	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.95419439
66	cotranslational protein targeting to membrane (GO:0006613)	2.94621437
67	protein targeting to ER (GO:0045047)	2.93717423
68	protein complex biogenesis (GO:0070271)	2.92954918
69	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.92884394
70	negative regulation of mast cell activation (GO:0033004)	2.90859027
71	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.89897931
72	iron-sulfur cluster assembly (GO:0016226)	2.89072272
73	metallo-sulfur cluster assembly (GO:0031163)	2.89072272
74	regulation of T cell mediated cytotoxicity (GO:0001914)	2.88102575
75	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.86352143
76	protein localization to endoplasmic reticulum (GO:0070972)	2.85400382
77	antigen processing and presentation via MHC class Ib (GO:0002475)	2.84753871
78	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.84416086
79	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.84247474
80	positive regulation of cell killing (GO:0031343)	2.83033470
81	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.82732974
82	negative thymic T cell selection (GO:0045060)	2.79648659
83	regulation of chronic inflammatory response (GO:0002676)	2.79231666
84	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.79113932
85	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.78907549
86	T cell receptor signaling pathway (GO:0050852)	2.78386071
87	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.76629587
88	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.74656590
89	negative regulation of telomere maintenance (GO:0032205)	2.72720368
90	positive regulation of tolerance induction (GO:0002645)	2.71592804
91	DNA dealkylation (GO:0035510)	2.71356979
92	positive regulation of granulocyte differentiation (GO:0030854)	2.70919610
93	regulation of interleukin-2 biosynthetic process (GO:0045076)	2.70578500
94	proteasome assembly (GO:0043248)	2.69585683
95	regulation of T cell apoptotic process (GO:0070232)	2.69406552
96	positive regulation of calcium-mediated signaling (GO:0050850)	2.68818042
97	protein-cofactor linkage (GO:0018065)	2.68665036
98	positive regulation of monocyte chemotaxis (GO:0090026)	2.66302424
99	positive regulation of T cell migration (GO:2000406)	2.66029863
100	regulation of T cell tolerance induction (GO:0002664)	2.65651502

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.83377651
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.78198964
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.66078040
4	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.53786019
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.53595563
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.42344206
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.36743384
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.11876064
9	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	3.04227221
10	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.90765359
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.76578855
12	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.64647069
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.64113840
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.58216056
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.52327996
16	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.46201960
17	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.42074339
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.30196926
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.24446350
20	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.97809724
21	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.97556481
22	FOXP3_21729870_ChIP-Seq_TREG_Human	1.97451434
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.95236731
24	MYB_26560356_Chip-Seq_TH2_Human	1.95215146
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.87000409
26	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.81762316
27	GATA3_26560356_Chip-Seq_TH2_Human	1.78017188
28	VDR_22108803_ChIP-Seq_LS180_Human	1.74117774
29	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.74082468
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.69288276
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.69144640
32	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.68129593
33	RUNX_20019798_ChIP-Seq_JUKART_Human	1.60965033
34	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.53833992
35	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.50841378
36	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.49609134
37	IGF1R_20145208_ChIP-Seq_DFB_Human	1.49465229
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.48533504
39	GATA3_27048872_Chip-Seq_THYMUS_Human	1.48347070
40	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.46003292
41	AR_20517297_ChIP-Seq_VCAP_Human	1.43305854
42	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.42490389
43	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.40002117
44	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.39733630
45	MYC_18940864_ChIP-ChIP_HL60_Human	1.38511858
46	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.37573241
47	MYB_26560356_Chip-Seq_TH1_Human	1.36525422
48	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.32776996
49	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.32578937
50	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.30205867
51	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.25795260
52	NANOG_20526341_ChIP-Seq_ESCs_Human	1.22277383
53	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.22194132
54	ZNF274_21170338_ChIP-Seq_K562_Hela	1.17823176
55	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.17500498
56	ERG_20517297_ChIP-Seq_VCAP_Human	1.17148068
57	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.16214355
58	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.14876711
59	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.14493211
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.14297237
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.14297237
62	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.14204698
63	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.13403204
64	DCP1A_22483619_ChIP-Seq_HELA_Human	1.10319281
65	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.09530188
66	BCL6_27268052_Chip-Seq_Bcells_Human	1.05606627
67	MAF_26560356_Chip-Seq_TH2_Human	1.05194448
68	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.04829081
69	GATA3_26560356_Chip-Seq_TH1_Human	1.04561362
70	CIITA_25753668_ChIP-Seq_RAJI_Human	1.04474496
71	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.03570390
72	ER_23166858_ChIP-Seq_MCF-7_Human	1.03310707
73	SPI1_23547873_ChIP-Seq_NB4_Human	1.02475965
74	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.02178372
75	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.01863988
76	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.01349394
77	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.00811277
78	NCOR_22424771_ChIP-Seq_293T_Human	1.00360258
79	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.99777983
80	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.99727515
81	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99121329
82	HTT_18923047_ChIP-ChIP_STHdh_Human	0.98713487
83	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.98272849
84	STAT1_20625510_ChIP-Seq_HELA_Human	0.98153724
85	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.96870876
86	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.96809764
87	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.96205953
88	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.94799940
89	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.94764088
90	ERA_21632823_ChIP-Seq_H3396_Human	0.94059415
91	TTF2_22483619_ChIP-Seq_HELA_Human	0.93406710
92	P300_27268052_Chip-Seq_Bcells_Human	0.91613023
93	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.91102566
94	SOX2_19829295_ChIP-Seq_ESCs_Human	0.90872613
95	NANOG_19829295_ChIP-Seq_ESCs_Human	0.90872613
96	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.90494145
97	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.86882514
98	TAF2_19829295_ChIP-Seq_ESCs_Human	0.86521670
99	MYC_19829295_ChIP-Seq_ESCs_Human	0.85909808
100	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.85529386

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	5.25781835
2	MP0003763_abnormal_thymus_physiology	3.29673747
3	MP0000372_irregular_coat_pigmentation	3.07184506
4	MP0009785_altered_susceptibility_to	2.94150573
5	MP0001835_abnormal_antigen_presentation	2.91006162
6	MP0002138_abnormal_hepatobiliary_system	2.63885155
7	MP0001873_stomach_inflammation	2.58732374
8	MP0009333_abnormal_splenocyte_physiolog	2.56750732
9	MP0002163_abnormal_gland_morphology	2.34163891
10	MP0003866_abnormal_defecation	2.33442493
11	MP0000685_abnormal_immune_system	2.33101561
12	MP0005377_hearing/vestibular/ear_phenot	2.15775844
13	MP0003878_abnormal_ear_physiology	2.15775844
14	MP0008875_abnormal_xenobiotic_pharmacok	2.08811462
15	MP0001790_abnormal_immune_system	2.07755389
16	MP0005387_immune_system_phenotype	2.07755389
17	MP0009379_abnormal_foot_pigmentation	2.07365347
18	MP0001800_abnormal_humoral_immune	2.03300956
19	MP0002102_abnormal_ear_morphology	1.95799535
20	MP0001919_abnormal_reproductive_system	1.92949324
21	MP0005025_abnormal_response_to	1.87869679
22	MP0005000_abnormal_immune_tolerance	1.85337155
23	MP0005645_abnormal_hypothalamus_physiol	1.84005472
24	MP0002148_abnormal_hypersensitivity_rea	1.81528209
25	MP0005379_endocrine/exocrine_gland_phen	1.78347357
26	MP0008872_abnormal_physiological_respon	1.78099938
27	MP0002420_abnormal_adaptive_immunity	1.76735926
28	MP0003806_abnormal_nucleotide_metabolis	1.76504218
29	MP0002723_abnormal_immune_serum	1.76270176
30	MP0004145_abnormal_muscle_electrophysio	1.74944080
31	MP0003646_muscle_fatigue	1.74855883
32	MP0002166_altered_tumor_susceptibility	1.73767209
33	MP0001819_abnormal_immune_cell	1.72518374
34	MP0002452_abnormal_antigen_presenting	1.61858334
35	MP0005389_reproductive_system_phenotype	1.53281789
36	MP0003045_fibrosis	1.50119751
37	MP0003786_premature_aging	1.49678929
38	MP0002006_tumorigenesis	1.47119718
39	MP0010155_abnormal_intestine_physiology	1.46229403
40	MP0005075_abnormal_melanosome_morpholog	1.39509974
41	MP0002277_abnormal_respiratory_mucosa	1.37402684
42	MP0002736_abnormal_nociception_after	1.35258563
43	MP0003011_delayed_dark_adaptation	1.34755853
44	MP0001968_abnormal_touch/_nociception	1.30896589
45	MP0000716_abnormal_immune_system	1.29889820
46	MP0006082_CNS_inflammation	1.28134315
47	MP0005410_abnormal_fertilization	1.28087191
48	MP0001905_abnormal_dopamine_level	1.27810664
49	MP0002398_abnormal_bone_marrow	1.26877939
50	MP0002837_dystrophic_cardiac_calcinosis	1.25461951
51	MP0008058_abnormal_DNA_repair	1.23432108
52	MP0006036_abnormal_mitochondrial_physio	1.18904248
53	MP0003567_abnormal_fetal_cardiomyocyte	1.17059838
54	MP0002876_abnormal_thyroid_physiology	1.14968388
55	MP0003724_increased_susceptibility_to	1.13689660
56	MP0010386_abnormal_urinary_bladder	1.12802161
57	MP0001845_abnormal_inflammatory_respons	1.12139165
58	MP0009697_abnormal_copulation	1.11415699
59	MP0002405_respiratory_system_inflammati	1.10982764
60	MP0005310_abnormal_salivary_gland	1.10792431
61	MP0000689_abnormal_spleen_morphology	1.10243751
62	MP0003195_calcinosis	1.09009433
63	MP0000703_abnormal_thymus_morphology	1.07766275
64	MP0002933_joint_inflammation	1.05530873
65	MP0001986_abnormal_taste_sensitivity	1.04081369
66	MP0008469_abnormal_protein_level	1.03533366
67	MP0001764_abnormal_homeostasis	1.03091307
68	MP0003137_abnormal_impulse_conducting	1.00179009
69	MP0002429_abnormal_blood_cell	0.99286345
70	MP0002722_abnormal_immune_system	0.98962878
71	MP0005084_abnormal_gallbladder_morpholo	0.97552755
72	MP0002419_abnormal_innate_immunity	0.97340798
73	MP0000613_abnormal_salivary_gland	0.96574042
74	MP0009643_abnormal_urine_homeostasis	0.95770711
75	MP0005085_abnormal_gallbladder_physiolo	0.95679407
76	MP0005083_abnormal_biliary_tract	0.95144547
77	MP0005636_abnormal_mineral_homeostasis	0.94782064
78	MP0005551_abnormal_eye_electrophysiolog	0.94127790
79	MP0003186_abnormal_redox_activity	0.90843230
80	MP0005464_abnormal_platelet_physiology	0.88553851
81	MP0003448_altered_tumor_morphology	0.86520321
82	MP0004381_abnormal_hair_follicle	0.86179552
83	MP0006072_abnormal_retinal_apoptosis	0.85462144
84	MP0005166_decreased_susceptibility_to	0.84291280
85	MP0001765_abnormal_ion_homeostasis	0.82577261
86	MP0005646_abnormal_pituitary_gland	0.82275902
87	MP0009764_decreased_sensitivity_to	0.81220835
88	MP0005503_abnormal_tendon_morphology	0.79358812
89	MP0004147_increased_porphyrin_level	0.78300526
90	MP0005332_abnormal_amino_acid	0.78254235
91	MP0000749_muscle_degeneration	0.74366907
92	MP0003075_altered_response_to	0.74143171
93	MP0002693_abnormal_pancreas_physiology	0.73060580
94	MP0004134_abnormal_chest_morphology	0.72768281
95	MP0006035_abnormal_mitochondrial_morpho	0.71678257
96	MP0005319_abnormal_enzyme/_coenzyme	0.71647838
97	MP0001853_heart_inflammation	0.71538610
98	MP0002132_abnormal_respiratory_system	0.70796816
99	MP0002019_abnormal_tumor_incidence	0.70089593
100	MP0002160_abnormal_reproductive_system	0.69170768

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	5.06441953
2	Hypoproteinemia (HP:0003075)	4.89773693
3	Acute necrotizing encephalopathy (HP:0006965)	4.44635842
4	Mitochondrial inheritance (HP:0001427)	4.20373837
5	Abnormal mitochondria in muscle tissue (HP:0008316)	4.17742154
6	3-Methylglutaconic aciduria (HP:0003535)	4.13362149
7	IgG deficiency (HP:0004315)	3.84116235
8	Acute encephalopathy (HP:0006846)	3.81841841
9	Increased CSF lactate (HP:0002490)	3.73667189
10	Progressive macrocephaly (HP:0004481)	3.70296281
11	Hepatocellular necrosis (HP:0001404)	3.63963531
12	T lymphocytopenia (HP:0005403)	3.44618715
13	Abnormality of T cell number (HP:0011839)	3.31672546
14	Hepatic necrosis (HP:0002605)	3.25190637
15	Severe combined immunodeficiency (HP:0004430)	3.22940949
16	Abnormality of the prostate (HP:0008775)	3.18877129
17	Cerebral edema (HP:0002181)	3.09897785
18	Elevated erythrocyte sedimentation rate (HP:0003565)	3.08666789
19	Autoimmune hemolytic anemia (HP:0001890)	3.04685912
20	Increased intramyocellular lipid droplets (HP:0012240)	2.92131360
21	Abnormality of T cells (HP:0002843)	2.88163760
22	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.85546312
23	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.85546312
24	Increased hepatocellular lipid droplets (HP:0006565)	2.82891778
25	Chronic diarrhea (HP:0002028)	2.81212256
26	Stomatitis (HP:0010280)	2.79937313
27	Reduced antithrombin III activity (HP:0001976)	2.76126090
28	Pancytopenia (HP:0001876)	2.69013681
29	Oral leukoplakia (HP:0002745)	2.68918759
30	Renal Fanconi syndrome (HP:0001994)	2.58247600
31	Hypoalbuminemia (HP:0003073)	2.57149897
32	Abnormal albumin level (HP:0012116)	2.57149897
33	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.54812857
34	Increased serum lactate (HP:0002151)	2.52878667
35	Lactic acidosis (HP:0003128)	2.48040748
36	Pancreatic cysts (HP:0001737)	2.42984673
37	Combined immunodeficiency (HP:0005387)	2.42353178
38	Lipid accumulation in hepatocytes (HP:0006561)	2.42307037
39	Increased muscle lipid content (HP:0009058)	2.33733263
40	Optic disc pallor (HP:0000543)	2.30934313
41	Type I transferrin isoform profile (HP:0003642)	2.29895317
42	Methylmalonic acidemia (HP:0002912)	2.25806408
43	Gastrointestinal infarctions (HP:0005244)	2.25800284
44	Panhypogammaglobulinemia (HP:0003139)	2.22917976
45	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.22057677
46	Exercise intolerance (HP:0003546)	2.20647963
47	Thyroiditis (HP:0100646)	2.18499967
48	Abnormality of T cell physiology (HP:0011840)	2.14052651
49	Lethargy (HP:0001254)	2.13164303
50	Macrocytic anemia (HP:0001972)	2.12665523
51	Respiratory failure (HP:0002878)	2.12599092
52	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.11481592
53	Absent thumb (HP:0009777)	2.09784006
54	Exertional dyspnea (HP:0002875)	2.09317046
55	Pulmonary fibrosis (HP:0002206)	2.07809286
56	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.06724818
57	Generalized aminoaciduria (HP:0002909)	2.05883549
58	Abnormality of eosinophils (HP:0001879)	2.05366028
59	Congenital, generalized hypertrichosis (HP:0004540)	2.04176634
60	Methylmalonic aciduria (HP:0012120)	2.03667806
61	Abnormality of DNA repair (HP:0003254)	2.02754136
62	Congenital stationary night blindness (HP:0007642)	2.01620345
63	Hypothermia (HP:0002045)	2.00839577
64	Chest pain (HP:0100749)	2.00347605
65	Encephalitis (HP:0002383)	1.98431442
66	True hermaphroditism (HP:0010459)	1.97286441
67	Prostate neoplasm (HP:0100787)	1.96690623
68	IgM deficiency (HP:0002850)	1.95582625
69	Constricted visual fields (HP:0001133)	1.93562197
70	Pigmentary retinal degeneration (HP:0001146)	1.91448825
71	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.91062380
72	Abnormal number of erythroid precursors (HP:0012131)	1.90955555
73	Ureteral obstruction (HP:0006000)	1.90318742
74	Leukodystrophy (HP:0002415)	1.88873956
75	Abolished electroretinogram (ERG) (HP:0000550)	1.87113655
76	Abnormal drinking behavior (HP:0030082)	1.85080828
77	Polydipsia (HP:0001959)	1.85080828
78	Renal cortical cysts (HP:0000803)	1.84677478
79	Attenuation of retinal blood vessels (HP:0007843)	1.83892904
80	Amaurosis fugax (HP:0100576)	1.83069069
81	Tetany (HP:0001281)	1.81511660
82	Carpal bone hypoplasia (HP:0001498)	1.81009944
83	Pustule (HP:0200039)	1.80884401
84	Dicarboxylic aciduria (HP:0003215)	1.80289115
85	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.80289115
86	Abnormality of the renal cortex (HP:0011035)	1.80255158
87	Hypomagnesemia (HP:0002917)	1.79622801
88	CNS demyelination (HP:0007305)	1.79590611
89	Mesangial abnormality (HP:0001966)	1.79262848
90	Ketoacidosis (HP:0001993)	1.77939593
91	Glycosuria (HP:0003076)	1.77038818
92	Abnormality of urine glucose concentration (HP:0011016)	1.77038818
93	Abnormality of vitamin B metabolism (HP:0004340)	1.76492820
94	Abnormality of cells of the erythroid lineage (HP:0012130)	1.75874202
95	Ketosis (HP:0001946)	1.75619328
96	Cleft eyelid (HP:0000625)	1.74594228
97	Meningitis (HP:0001287)	1.74576349
98	Gangrene (HP:0100758)	1.73806648
99	Concave nail (HP:0001598)	1.73595286
100	Abnormal glycosylation (HP:0012345)	1.72605411

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	6.12822111
2	VRK2	3.83015702
3	KDR	3.79615022
4	BCKDK	3.08169045
5	TIE1	2.70923091
6	MAP4K1	2.63513920
7	MAP3K12	2.33728106
8	MST4	2.26532906
9	ZAK	2.16598678
10	TESK2	2.04564398
11	ADRBK2	1.93188341
12	GRK1	1.92892186
13	ITK	1.90993587
14	TEC	1.86270911
15	SCYL2	1.76737554
16	BUB1	1.74623278
17	TLK1	1.67396212
18	FRK	1.62429930
19	MUSK	1.60345771
20	VRK1	1.59808323
21	TAF1	1.58031166
22	NUAK1	1.52553648
23	SYK	1.49410826
24	TAOK3	1.45201249
25	BTK	1.36964520
26	TNK2	1.32258918
27	CDK19	1.31591683
28	FES	1.30651291
29	DAPK1	1.27124162
30	MAPKAPK3	1.26367880
31	PASK	1.15277399
32	BMPR1B	1.09449491
33	PRKCQ	1.09402878
34	GRK6	1.08410480
35	TESK1	1.07309155
36	GRK7	1.06427028
37	MYLK	1.04286414
38	WNK3	1.00048614
39	IKBKE	0.96653214
40	LIMK1	0.96100607
41	IKBKB	0.94880768
42	OBSCN	0.89974722
43	WNK4	0.89518776
44	EIF2AK3	0.89474288
45	ERBB3	0.89258477
46	LCK	0.88874770
47	CSK	0.88272461
48	SRPK1	0.84217200
49	MAPKAPK5	0.79246484
50	INSRR	0.78644989
51	NEK1	0.77716506
52	RIPK4	0.74946474
53	LYN	0.73388002
54	PINK1	0.73350264
55	ZAP70	0.72526474
56	JAK3	0.71703652
57	NME2	0.70121569
58	MAP3K11	0.68294180
59	OXSR1	0.67335311
60	GRK5	0.67094971
61	TRIM28	0.66870009
62	PIM2	0.66710257
63	PIK3CG	0.66673452
64	DAPK3	0.66398592
65	TAOK2	0.63754728
66	CSNK1G3	0.63561003
67	PHKG2	0.56993258
68	PHKG1	0.56993258
69	STK39	0.56334145
70	CSF1R	0.56106443
71	PDK2	0.56034407
72	MAP2K6	0.54852254
73	IGF1R	0.53555169
74	PIM1	0.50889791
75	BMPR2	0.50218992
76	RPS6KA5	0.49310936
77	NME1	0.48788146
78	MAP4K2	0.47121500
79	CHEK2	0.46819474
80	STK16	0.45695627
81	CDK8	0.45600044
82	ADRBK1	0.45109387
83	AURKA	0.43221614
84	PRKCA	0.38505408
85	CSNK1G2	0.37611587
86	HCK	0.37527351
87	PRKG2	0.34713412
88	ILK	0.34659070
89	RPS6KA4	0.33545457
90	CSNK2A1	0.32914240
91	CSNK1G1	0.32350488
92	TBK1	0.32285023
93	KIT	0.32077592
94	AURKB	0.31830674
95	PRKACA	0.31736367
96	ABL1	0.30567833
97	CAMK1	0.29949984
98	PLK4	0.29797726
99	CDK3	0.29734445
100	BLK	0.29548786

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	4.59509016
2	Proteasome_Homo sapiens_hsa03050	4.53785925
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.68084378
4	Ribosome_Homo sapiens_hsa03010	3.60068888
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.13393007
6	Parkinsons disease_Homo sapiens_hsa05012	2.97382919
7	Allograft rejection_Homo sapiens_hsa05330	2.91641021
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.50496247
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.29157739
10	Antigen processing and presentation_Homo sapiens_hsa04612	2.13670780
11	Asthma_Homo sapiens_hsa05310	2.07019882
12	Hematopoietic cell lineage_Homo sapiens_hsa04640	2.03075724
13	Alzheimers disease_Homo sapiens_hsa05010	1.95018568
14	Type I diabetes mellitus_Homo sapiens_hsa04940	1.93167066
15	RNA polymerase_Homo sapiens_hsa03020	1.91482148
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.87096317
17	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.81048136
18	Huntingtons disease_Homo sapiens_hsa05016	1.80671508
19	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.63896843
20	Rheumatoid arthritis_Homo sapiens_hsa05323	1.47112150
21	RNA degradation_Homo sapiens_hsa03018	1.34378344
22	Homologous recombination_Homo sapiens_hsa03440	1.33472543
23	DNA replication_Homo sapiens_hsa03030	1.26579804
24	Sulfur relay system_Homo sapiens_hsa04122	1.24888431
25	Cardiac muscle contraction_Homo sapiens_hsa04260	1.24399614
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.23758464
27	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.22968491
28	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.21187509
29	Basal transcription factors_Homo sapiens_hsa03022	1.19994605
30	Base excision repair_Homo sapiens_hsa03410	1.19869581
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.17877799
32	One carbon pool by folate_Homo sapiens_hsa00670	1.16414926
33	Protein export_Homo sapiens_hsa03060	1.16402037
34	Nucleotide excision repair_Homo sapiens_hsa03420	1.14765835
35	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.11093610
36	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.05951906
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.05179698
38	Phototransduction_Homo sapiens_hsa04744	1.00945040
39	Caffeine metabolism_Homo sapiens_hsa00232	0.99777797
40	Viral myocarditis_Homo sapiens_hsa05416	0.98050300
41	Mismatch repair_Homo sapiens_hsa03430	0.95780123
42	Propanoate metabolism_Homo sapiens_hsa00640	0.91322785
43	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.91294302
44	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.88290160
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.86782498
46	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.85612480
47	Purine metabolism_Homo sapiens_hsa00230	0.80124457
48	Ether lipid metabolism_Homo sapiens_hsa00565	0.78565563
49	Spliceosome_Homo sapiens_hsa03040	0.78242995
50	Peroxisome_Homo sapiens_hsa04146	0.78180782
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.77647398
52	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.76172105
53	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.73142309
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73045587
55	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.71760146
56	Measles_Homo sapiens_hsa05162	0.71758977
57	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.70024437
58	Olfactory transduction_Homo sapiens_hsa04740	0.69618603
59	Tryptophan metabolism_Homo sapiens_hsa00380	0.65451032
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64073961
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.63111701
62	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.62150117
63	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.62124066
64	Retinol metabolism_Homo sapiens_hsa00830	0.62061439
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59558662
66	Nitrogen metabolism_Homo sapiens_hsa00910	0.57364678
67	Folate biosynthesis_Homo sapiens_hsa00790	0.56945630
68	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.56093978
69	Collecting duct acid secretion_Homo sapiens_hsa04966	0.55696944
70	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55532779
71	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.55203757
72	Fanconi anemia pathway_Homo sapiens_hsa03460	0.54746683
73	RNA transport_Homo sapiens_hsa03013	0.53895602
74	Metabolic pathways_Homo sapiens_hsa01100	0.53283414
75	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.51927479
76	Butanoate metabolism_Homo sapiens_hsa00650	0.51887503
77	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.49185475
78	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.46910867
79	Non-homologous end-joining_Homo sapiens_hsa03450	0.45573669
80	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.45280770
81	Selenocompound metabolism_Homo sapiens_hsa00450	0.43843474
82	Glutathione metabolism_Homo sapiens_hsa00480	0.43340774
83	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.43308101
84	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.42327795
85	Regulation of autophagy_Homo sapiens_hsa04140	0.41721471
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.41519946
87	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.39109393
88	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.35198851
89	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.31616229
90	Sulfur metabolism_Homo sapiens_hsa00920	0.29759393
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.29340110
92	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.29002066
93	Pyruvate metabolism_Homo sapiens_hsa00620	0.28525646
94	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.28167647
95	Malaria_Homo sapiens_hsa05144	0.27724936
96	Herpes simplex infection_Homo sapiens_hsa05168	0.27565908
97	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.25888294
98	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.19882716
99	ABC transporters_Homo sapiens_hsa02010	0.19718453
100	Leishmaniasis_Homo sapiens_hsa05140	0.17585869

RPL29P12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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