ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of isotype switching to IgG isotypes (GO:0048302)	5.98331487
2	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.83456918
3	negative regulation of T-helper cell differentiation (GO:0045623)	4.80119833
4	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	4.80119833
5	regulation of immunoglobulin secretion (GO:0051023)	4.52427834
6	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	4.48711570
7	regulation of mitotic spindle checkpoint (GO:1903504)	4.48711570
8	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	4.42289082
9	positive regulation of isotype switching (GO:0045830)	4.41603236
10	positive regulation of DNA recombination (GO:0045911)	4.35859792
11	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	4.32743331
12	proteasome assembly (GO:0043248)	4.25402921
13	regulation of regulatory T cell differentiation (GO:0045589)	4.22084141
14	transcription from mitochondrial promoter (GO:0006390)	3.99186578
15	transcription elongation from RNA polymerase I promoter (GO:0006362)	3.93318348
16	negative regulation of alpha-beta T cell differentiation (GO:0046639)	3.86578320
17	termination of RNA polymerase I transcription (GO:0006363)	3.83188246
18	negative regulation of B cell apoptotic process (GO:0002903)	3.79104341
19	respiratory chain complex IV assembly (GO:0008535)	3.74169134
20	interferon-gamma production (GO:0032609)	3.47487263
21	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.46050283
22	lactate metabolic process (GO:0006089)	3.42257579
23	prenylation (GO:0097354)	3.42160484
24	protein prenylation (GO:0018342)	3.42160484
25	positive regulation of interleukin-17 production (GO:0032740)	3.38797316
26	regulation of B cell receptor signaling pathway (GO:0050855)	3.37839574
27	ribosome assembly (GO:0042255)	3.23207424
28	protein K11-linked deubiquitination (GO:0035871)	3.22183017
29	transcription initiation from RNA polymerase I promoter (GO:0006361)	3.22039886
30	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.15971493
31	attachment of spindle microtubules to kinetochore (GO:0008608)	3.15634225
32	water-soluble vitamin biosynthetic process (GO:0042364)	3.14708568
33	positive regulation of B cell mediated immunity (GO:0002714)	3.13367295
34	positive regulation of immunoglobulin mediated immune response (GO:0002891)	3.13367295
35	DNA deamination (GO:0045006)	3.12403020
36	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.11273074
37	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	3.07639524
38	T-helper cell differentiation (GO:0042093)	3.07639524
39	regulation of T cell receptor signaling pathway (GO:0050856)	3.06598532
40	pseudouridine synthesis (GO:0001522)	3.04251603
41	pore complex assembly (GO:0046931)	3.01781909
42	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	3.00477504
43	regulation of chronic inflammatory response (GO:0002676)	3.00319841
44	regulation of isotype switching (GO:0045191)	3.00217817
45	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.99385865
46	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.98799700
47	mitochondrial RNA metabolic process (GO:0000959)	2.98053135
48	transcription from RNA polymerase I promoter (GO:0006360)	2.97202736
49	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.94838946
50	positive regulation of immunoglobulin production (GO:0002639)	2.93300324
51	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.90114054
52	regulation of memory T cell differentiation (GO:0043380)	2.89394984
53	alpha-beta T cell differentiation involved in immune response (GO:0002293)	2.88023473
54	alpha-beta T cell activation involved in immune response (GO:0002287)	2.88023473
55	T cell differentiation involved in immune response (GO:0002292)	2.88023473
56	regulation of B cell apoptotic process (GO:0002902)	2.86456830
57	CD4-positive, alpha-beta T cell differentiation (GO:0043367)	2.85088556
58	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.81574864
59	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.80205129
60	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.80205129
61	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.80205129
62	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.79359602
63	cytokine biosynthetic process (GO:0042089)	2.78949863
64	DNA replication checkpoint (GO:0000076)	2.78880931
65	negative regulation of alpha-beta T cell activation (GO:0046636)	2.77615820
66	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.73831018
67	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.73831018
68	CD4-positive, alpha-beta T cell activation (GO:0035710)	2.70253444
69	ribosome biogenesis (GO:0042254)	2.69487633
70	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.69278973
71	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.68769784
72	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.68769784
73	negative regulation of thymocyte apoptotic process (GO:0070244)	2.68442721
74	cytochrome complex assembly (GO:0017004)	2.67259181
75	alpha-beta T cell differentiation (GO:0046632)	2.66794513
76	positive regulation of granulocyte differentiation (GO:0030854)	2.65960059
77	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.64317428
78	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.64317428
79	regulation of immunoglobulin production (GO:0002637)	2.63076112
80	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.62103339
81	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.58486076
82	regulation of T-helper cell differentiation (GO:0045622)	2.57671063
83	rRNA catabolic process (GO:0016075)	2.55672043
84	signal peptide processing (GO:0006465)	2.54689184
85	hepatocyte apoptotic process (GO:0097284)	2.54400734
86	DNA catabolic process, exonucleolytic (GO:0000738)	2.53952249
87	regulation of cellular amino acid metabolic process (GO:0006521)	2.53585198
88	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.53411277
89	tRNA processing (GO:0008033)	2.52877126
90	rRNA processing (GO:0006364)	2.52669991
91	protein complex biogenesis (GO:0070271)	2.52036946
92	male meiosis (GO:0007140)	2.50819766
93	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.50310659
94	keratinocyte development (GO:0003334)	2.49079228
95	rRNA metabolic process (GO:0016072)	2.48909635
96	intestinal epithelial cell development (GO:0060576)	2.47802307
97	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.47323592
98	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.46074782
99	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.46074782
100	isotype switching (GO:0045190)	2.46074782

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.06274894
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.70083269
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.60069802
4	NOTCH1_21737748_ChIP-Seq_TLL_Human	3.51942715
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.36059153
6	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.33086163
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.00001474
8	ELK1_19687146_ChIP-ChIP_HELA_Human	2.81356886
9	VDR_23849224_ChIP-Seq_CD4+_Human	2.55866720
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.39392198
11	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.38021886
12	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.29380495
13	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.27523792
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.26276639
15	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.23155933
16	VDR_22108803_ChIP-Seq_LS180_Human	2.14926358
17	FOXP3_21729870_ChIP-Seq_TREG_Human	2.09750993
18	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.09469241
19	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.04980897
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.03772291
21	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.03632226
22	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.01115168
23	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.00090628
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.96585884
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.92961550
26	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.92290470
27	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.90470194
28	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.88101008
29	ZNF274_21170338_ChIP-Seq_K562_Hela	1.85531389
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.68950182
31	EWS_26573619_Chip-Seq_HEK293_Human	1.67249630
32	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.63923334
33	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.58841664
34	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.48349241
35	TAF15_26573619_Chip-Seq_HEK293_Human	1.47617607
36	GATA3_26560356_Chip-Seq_TH2_Human	1.47388932
37	MYC_18940864_ChIP-ChIP_HL60_Human	1.45585475
38	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.45125138
39	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.42003929
40	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.41719947
41	FUS_26573619_Chip-Seq_HEK293_Human	1.40501318
42	GATA1_22025678_ChIP-Seq_K562_Human	1.39634491
43	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39468117
44	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.32726070
45	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.31402407
46	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.31350857
47	MYB_26560356_Chip-Seq_TH2_Human	1.29006953
48	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.28894860
49	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.24755009
50	ER_23166858_ChIP-Seq_MCF-7_Human	1.22837811
51	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.22602773
52	P300_19829295_ChIP-Seq_ESCs_Human	1.21652995
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.20507099
54	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17149762
55	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.16456539
56	DCP1A_22483619_ChIP-Seq_HELA_Human	1.16354674
57	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.15974676
58	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.15248594
59	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.14929307
60	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.14757218
61	ELF5_23300383_ChIP-Seq_T47D_Human	1.14669996
62	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.14669211
63	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.13737153
64	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.12469546
65	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.11033281
66	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.08684652
67	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.06462782
68	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.04876306
69	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.04646178
70	CDX2_22108803_ChIP-Seq_LS180_Human	1.02947523
71	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.98887994
72	CBP_20019798_ChIP-Seq_JUKART_Human	0.98887994
73	GATA3_27048872_Chip-Seq_THYMUS_Human	0.98825500
74	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.97576942
75	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.97576942
76	TTF2_22483619_ChIP-Seq_HELA_Human	0.97000607
77	MYB_26560356_Chip-Seq_TH1_Human	0.96148784
78	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.95710884
79	KDM5A_27292631_Chip-Seq_BREAST_Human	0.95674464
80	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.95368834
81	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	0.94785421
82	TP53_22573176_ChIP-Seq_HFKS_Human	0.93305254
83	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.92109801
84	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.92068596
85	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.89544720
86	RUNX_20019798_ChIP-Seq_JUKART_Human	0.87465795
87	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.86843903
88	BCAT_22108803_ChIP-Seq_LS180_Human	0.84269026
89	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.84241626
90	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.84171733
91	NANOG_19829295_ChIP-Seq_ESCs_Human	0.83450867
92	SOX2_19829295_ChIP-Seq_ESCs_Human	0.83450867
93	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.83190891
94	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.82686092
95	PHF8_20622853_ChIP-Seq_HELA_Human	0.82550148
96	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.82349137
97	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.81915482
98	GATA3_26560356_Chip-Seq_TH1_Human	0.81613357
99	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.80152655
100	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.80082594

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.52718190
2	MP0008057_abnormal_DNA_replication	3.92042448
3	MP0001835_abnormal_antigen_presentation	3.06451550
4	MP0003786_premature_aging	2.99016530
5	MP0008058_abnormal_DNA_repair	2.78971347
6	MP0005671_abnormal_response_to	2.52483440
7	MP0001853_heart_inflammation	2.45229057
8	MP0000427_abnormal_hair_cycle	2.25083204
9	MP0006072_abnormal_retinal_apoptosis	2.20352152
10	MP0003763_abnormal_thymus_physiology	2.20132840
11	MP0009697_abnormal_copulation	2.14627054
12	MP0003718_maternal_effect	2.11352509
13	MP0002006_tumorigenesis	2.10319411
14	MP0005670_abnormal_white_adipose	2.06139183
15	MP0002166_altered_tumor_susceptibility	1.99880349
16	MP0003195_calcinosis	1.97230532
17	MP0009785_altered_susceptibility_to	1.95172157
18	MP0010094_abnormal_chromosome_stability	1.89167129
19	MP0002009_preneoplasia	1.88701556
20	MP0001873_stomach_inflammation	1.83578429
21	MP0002396_abnormal_hematopoietic_system	1.78687451
22	MP0003950_abnormal_plasma_membrane	1.74770071
23	MP0001800_abnormal_humoral_immune	1.70598337
24	MP0002148_abnormal_hypersensitivity_rea	1.70114167
25	MP0008872_abnormal_physiological_respon	1.67936354
26	MP0000685_abnormal_immune_system	1.67492765
27	MP0008875_abnormal_xenobiotic_pharmacok	1.66315029
28	MP0000569_abnormal_digit_pigmentation	1.65165411
29	MP0002102_abnormal_ear_morphology	1.64328606
30	MP0004957_abnormal_blastocyst_morpholog	1.62647230
31	MP0001501_abnormal_sleep_pattern	1.61925538
32	MP0008995_early_reproductive_senescence	1.60217821
33	MP0006035_abnormal_mitochondrial_morpho	1.54972531
34	MP0002138_abnormal_hepatobiliary_system	1.51528335
35	MP0002405_respiratory_system_inflammati	1.50128467
36	MP0005084_abnormal_gallbladder_morpholo	1.49228884
37	MP0001984_abnormal_olfaction	1.47690880
38	MP0006036_abnormal_mitochondrial_physio	1.47577772
39	MP0005551_abnormal_eye_electrophysiolog	1.40295885
40	MP0003646_muscle_fatigue	1.38432338
41	MP0005253_abnormal_eye_physiology	1.35046564
42	MP0004808_abnormal_hematopoietic_stem	1.34550571
43	MP0006082_CNS_inflammation	1.30454839
44	MP0003866_abnormal_defecation	1.30051874
45	MP0002723_abnormal_immune_serum	1.29858094
46	MP0003787_abnormal_imprinting	1.29108431
47	MP0000689_abnormal_spleen_morphology	1.24413052
48	MP0008007_abnormal_cellular_replicative	1.23304302
49	MP0000383_abnormal_hair_follicle	1.21677795
50	MP0005000_abnormal_immune_tolerance	1.20807475
51	MP0002398_abnormal_bone_marrow	1.20317824
52	MP0000703_abnormal_thymus_morphology	1.19311702
53	MP0000647_abnormal_sebaceous_gland	1.19213130
54	MP0004147_increased_porphyrin_level	1.17817566
55	MP0001790_abnormal_immune_system	1.16246180
56	MP0005387_immune_system_phenotype	1.16246180
57	MP0002452_abnormal_antigen_presenting	1.16164734
58	MP0009764_decreased_sensitivity_to	1.13969402
59	MP0002420_abnormal_adaptive_immunity	1.10941475
60	MP0010678_abnormal_skin_adnexa	1.10589480
61	MP0001819_abnormal_immune_cell	1.10426842
62	MP0009333_abnormal_splenocyte_physiolog	1.08982345
63	MP0005395_other_phenotype	1.08068590
64	MP0001661_extended_life_span	1.07432393
65	MP0003890_abnormal_embryonic-extraembry	1.07267087
66	MP0003045_fibrosis	1.06654992
67	MP0006292_abnormal_olfactory_placode	1.06462151
68	MP0005025_abnormal_response_to	1.05732865
69	MP0003111_abnormal_nucleus_morphology	1.01406295
70	MP0005645_abnormal_hypothalamus_physiol	1.01385797
71	MP0001845_abnormal_inflammatory_respons	1.01380999
72	MP0000716_abnormal_immune_system	1.00810615
73	MP0003077_abnormal_cell_cycle	0.98292666
74	MP0002019_abnormal_tumor_incidence	0.98174065
75	MP0002722_abnormal_immune_system	0.96011303
76	MP0005310_abnormal_salivary_gland	0.91889618
77	MP0003693_abnormal_embryo_hatching	0.90526037
78	MP0002277_abnormal_respiratory_mucosa	0.89950563
79	MP0002332_abnormal_exercise_endurance	0.88162117
80	MP0002429_abnormal_blood_cell	0.87334978
81	MP0002938_white_spotting	0.84293457
82	MP0010155_abnormal_intestine_physiology	0.83347490
83	MP0005410_abnormal_fertilization	0.80808642
84	MP0002970_abnormal_white_adipose	0.78459776
85	MP0001764_abnormal_homeostasis	0.78241780
86	MP0008873_increased_physiological_sensi	0.76957750
87	MP0002693_abnormal_pancreas_physiology	0.76066294
88	MP0004484_altered_response_of	0.73377217
89	MP0005266_abnormal_metabolism	0.69306705
90	MP0005408_hypopigmentation	0.69304571
91	MP0001929_abnormal_gametogenesis	0.66215608
92	MP0001119_abnormal_female_reproductive	0.63069017
93	MP0004215_abnormal_myocardial_fiber	0.62979444
94	MP0002234_abnormal_pharynx_morphology	0.62150274
95	MP0000358_abnormal_cell_content/	0.62041231
96	MP0000613_abnormal_salivary_gland	0.61958200
97	MP0002210_abnormal_sex_determination	0.60919986
98	MP0006276_abnormal_autonomic_nervous	0.58877765
99	MP0002168_other_aberrant_phenotype	0.57678872
100	MP0009115_abnormal_fat_cell	0.57009414

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Stomatitis (HP:0010280)	5.79016356
2	Autoimmune hemolytic anemia (HP:0001890)	4.84905577
3	IgG deficiency (HP:0004315)	3.83265965
4	Abnormality of the pons (HP:0007361)	3.05086143
5	Lip pit (HP:0100267)	3.01802905
6	Elevated erythrocyte sedimentation rate (HP:0003565)	2.96787432
7	Alveolar cell carcinoma (HP:0006519)	2.96365963
8	Abnormality of the prostate (HP:0008775)	2.88947524
9	Increased CSF lactate (HP:0002490)	2.82868543
10	Aplastic anemia (HP:0001915)	2.79407640
11	Neoplasm of the tracheobronchial system (HP:0100552)	2.79004364
12	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.78415038
13	Dyschromatopsia (HP:0007641)	2.73296240
14	Pancreatic cysts (HP:0001737)	2.72826595
15	Type I transferrin isoform profile (HP:0003642)	2.67284011
16	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.61184338
17	Abnormality of alanine metabolism (HP:0010916)	2.61184338
18	Hyperalaninemia (HP:0003348)	2.61184338
19	Acute necrotizing encephalopathy (HP:0006965)	2.57433297
20	Multiple enchondromatosis (HP:0005701)	2.53762201
21	Hypoplasia of the pons (HP:0012110)	2.49484877
22	Lipid accumulation in hepatocytes (HP:0006561)	2.49154469
23	Mitochondrial inheritance (HP:0001427)	2.48671859
24	Progressive macrocephaly (HP:0004481)	2.48325347
25	Increased hepatocellular lipid droplets (HP:0006565)	2.47133385
26	Prostate neoplasm (HP:0100787)	2.44313935
27	Abnormal mitochondria in muscle tissue (HP:0008316)	2.42185913
28	Hip dysplasia (HP:0001385)	2.37211011
29	Abnormality of the nasal septum (HP:0000419)	2.36940509
30	Renal Fanconi syndrome (HP:0001994)	2.36027214
31	3-Methylglutaconic aciduria (HP:0003535)	2.35334085
32	Hypoproteinemia (HP:0003075)	2.35295802
33	Congenital stationary night blindness (HP:0007642)	2.34484908
34	Horizontal nystagmus (HP:0000666)	2.34218446
35	Molar tooth sign on MRI (HP:0002419)	2.33134436
36	Abnormality of midbrain morphology (HP:0002418)	2.33134436
37	IgA deficiency (HP:0002720)	2.31781602
38	Abnormal rod and cone electroretinograms (HP:0008323)	2.29733529
39	Gaze-evoked nystagmus (HP:0000640)	2.29088547
40	Increased serum lactate (HP:0002151)	2.28709133
41	IgM deficiency (HP:0002850)	2.25871218
42	Pancytopenia (HP:0001876)	2.24569005
43	Abnormality of T cell physiology (HP:0011840)	2.24022302
44	Abnormality of the labia minora (HP:0012880)	2.23689530
45	Acute encephalopathy (HP:0006846)	2.23193721
46	Depressed nasal tip (HP:0000437)	2.23146507
47	Submucous cleft hard palate (HP:0000176)	2.18968862
48	Abnormality of chromosome stability (HP:0003220)	2.13176389
49	Hepatocellular necrosis (HP:0001404)	2.13020969
50	Abnormal protein N-linked glycosylation (HP:0012347)	2.12853389
51	Abnormal protein glycosylation (HP:0012346)	2.12853389
52	Abnormal glycosylation (HP:0012345)	2.12853389
53	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.12853389
54	Abolished electroretinogram (ERG) (HP:0000550)	2.11197536
55	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.10883874
56	Abnormal drinking behavior (HP:0030082)	2.09707159
57	Polydipsia (HP:0001959)	2.09707159
58	Prominent metopic ridge (HP:0005487)	2.09576810
59	Attenuation of retinal blood vessels (HP:0007843)	2.08605118
60	Abnormality of the metopic suture (HP:0005556)	2.02883497
61	Congenital, generalized hypertrichosis (HP:0004540)	1.99220738
62	Hypothermia (HP:0002045)	1.96215064
63	Meckel diverticulum (HP:0002245)	1.95330081
64	Abnormality of the ileum (HP:0001549)	1.93762117
65	Aplasia of the musculature (HP:0100854)	1.93609061
66	Sparse lateral eyebrow (HP:0005338)	1.92418299
67	Birth length less than 3rd percentile (HP:0003561)	1.91707193
68	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.88980631
69	Hypoalbuminemia (HP:0003073)	1.88378211
70	Abnormal albumin level (HP:0012116)	1.88378211
71	Abnormality of T cells (HP:0002843)	1.87743171
72	Pancreatic fibrosis (HP:0100732)	1.86841959
73	Chromsome breakage (HP:0040012)	1.86718700
74	Acute myeloid leukemia (HP:0004808)	1.86260448
75	Facial diplegia (HP:0001349)	1.84680491
76	Optic disc pallor (HP:0000543)	1.84288122
77	Hydroxyprolinuria (HP:0003080)	1.83445714
78	Abnormality of proline metabolism (HP:0010907)	1.83445714
79	Abnormal biliary tract physiology (HP:0012439)	1.81794246
80	Bile duct proliferation (HP:0001408)	1.81794246
81	Hepatic necrosis (HP:0002605)	1.80516615
82	Intestinal atresia (HP:0011100)	1.78965170
83	Thyroiditis (HP:0100646)	1.77244259
84	Posterior subcapsular cataract (HP:0007787)	1.76946982
85	Decreased central vision (HP:0007663)	1.75653016
86	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.74471292
87	Cleft eyelid (HP:0000625)	1.72832911
88	Panhypogammaglobulinemia (HP:0003139)	1.71644143
89	Clubbing of toes (HP:0100760)	1.71600852
90	Polyneuropathy (HP:0001271)	1.70646968
91	Cerebral edema (HP:0002181)	1.66414901
92	Abnormality of serum amino acid levels (HP:0003112)	1.66252993
93	Pendular nystagmus (HP:0012043)	1.65539930
94	True hermaphroditism (HP:0010459)	1.64173918
95	Sloping forehead (HP:0000340)	1.64077308
96	Pulmonary infiltrates (HP:0002113)	1.63617766
97	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.63613183
98	Opisthotonus (HP:0002179)	1.63303799
99	Abnormality of the fingertips (HP:0001211)	1.63293195
100	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.63179781

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	AKT3	4.71517273
2	MST4	4.10845042
3	FRK	3.85852804
4	ZAK	3.80164614
5	TSSK6	3.00403532
6	MKNK1	2.73907318
7	MKNK2	2.71576865
8	EIF2AK1	2.49955143
9	BMPR1B	2.34233917
10	PBK	2.24970757
11	TLK1	1.99396084
12	STK24	1.88400362
13	ITK	1.88112735
14	JAK3	1.77881073
15	TEC	1.76458383
16	ACVR1B	1.72546169
17	TXK	1.71017828
18	BRSK2	1.69858439
19	NME1	1.60911714
20	EIF2AK3	1.59316391
21	TRIM28	1.52164646
22	ADRBK2	1.50717173
23	NUAK1	1.50221670
24	SRPK1	1.48666584
25	TAOK3	1.44082812
26	BUB1	1.38804121
27	MAPKAPK3	1.30225532
28	PDK2	1.19869024
29	PIK3CG	1.19504049
30	CDK8	1.15277358
31	MAP4K1	1.15177998
32	MAP4K2	1.15092917
33	IKBKB	1.12473366
34	PLK4	1.12156764
35	GRK1	1.12096428
36	VRK1	1.08792015
37	PLK3	1.08476218
38	ERBB4	1.01924682
39	PAK3	0.99667896
40	RPS6KA5	0.98653280
41	VRK2	0.95487713
42	TGFBR1	0.88920424
43	TIE1	0.86501992
44	INSRR	0.86347678
45	SGK2	0.81963723
46	STK10	0.80481339
47	PIK3CA	0.80029657
48	BMPR2	0.76451495
49	WNK3	0.75549922
50	LCK	0.75436933
51	PINK1	0.75148729
52	IKBKE	0.74064762
53	KIT	0.72680544
54	ALK	0.72433628
55	MAP3K13	0.69968025
56	BTK	0.69238264
57	STK39	0.68611700
58	IGF1R	0.68206285
59	WEE1	0.63626699
60	OXSR1	0.59456281
61	EIF2AK2	0.58564834
62	SGK3	0.57450674
63	CDC7	0.56884716
64	CHEK2	0.55639928
65	FER	0.54637542
66	SIK3	0.54598442
67	NEK1	0.54580893
68	MAPKAPK5	0.52719533
69	STK38L	0.52662603
70	NLK	0.52610280
71	PRKCQ	0.51401324
72	IRAK1	0.51057675
73	STK3	0.50255600
74	ERBB3	0.49879381
75	CHUK	0.48031820
76	BRD4	0.45936669
77	MAPK11	0.45878476
78	ADRBK1	0.45264486
79	MELK	0.43669139
80	CSNK1G1	0.43658571
81	PIM1	0.43497753
82	WNK4	0.42820577
83	TNIK	0.42216501
84	TTK	0.42140033
85	NME2	0.42104321
86	STK4	0.41553413
87	CHEK1	0.41197186
88	FGFR1	0.39057371
89	ATR	0.39015617
90	MAP3K12	0.38835533
91	MYLK	0.37545313
92	PRKCI	0.37007097
93	FES	0.34091979
94	MAP3K14	0.33999891
95	GRK7	0.33994111
96	PLK1	0.33491871
97	ATM	0.33261989
98	CSNK2A2	0.31877476
99	TRPM7	0.30632654
100	PLK2	0.29154027

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.84752867
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.26111285
3	Vitamin B6 metabolism_Homo sapiens_hsa00750	3.14572919
4	Allograft rejection_Homo sapiens_hsa05330	3.08064039
5	Asthma_Homo sapiens_hsa05310	3.06708030
6	Basal transcription factors_Homo sapiens_hsa03022	3.02335643
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.95636374
8	RNA polymerase_Homo sapiens_hsa03020	2.66540532
9	Protein export_Homo sapiens_hsa03060	2.58872912
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.56677390
11	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.38410467
12	RNA degradation_Homo sapiens_hsa03018	2.22950232
13	Selenocompound metabolism_Homo sapiens_hsa00450	2.14243255
14	Non-homologous end-joining_Homo sapiens_hsa03450	2.13640603
15	One carbon pool by folate_Homo sapiens_hsa00670	2.08318822
16	Primary immunodeficiency_Homo sapiens_hsa05340	2.07582936
17	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.83484269
18	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.82082052
19	Type I diabetes mellitus_Homo sapiens_hsa04940	1.80166643
20	Graft-versus-host disease_Homo sapiens_hsa05332	1.79324832
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.79161610
22	Homologous recombination_Homo sapiens_hsa03440	1.75205266
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.67279282
24	Oxidative phosphorylation_Homo sapiens_hsa00190	1.67004891
25	RNA transport_Homo sapiens_hsa03013	1.62310690
26	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.61411310
27	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.53749325
28	Measles_Homo sapiens_hsa05162	1.52318736
29	Circadian rhythm_Homo sapiens_hsa04710	1.46471152
30	Mismatch repair_Homo sapiens_hsa03430	1.33081144
31	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.27823547
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.27425515
33	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.24031380
34	Parkinsons disease_Homo sapiens_hsa05012	1.21718389
35	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.17881578
36	Rheumatoid arthritis_Homo sapiens_hsa05323	1.11688887
37	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.09672589
38	Spliceosome_Homo sapiens_hsa03040	1.07308133
39	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.04765535
40	DNA replication_Homo sapiens_hsa03030	1.03318756
41	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.00467726
42	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.99889162
43	Pyrimidine metabolism_Homo sapiens_hsa00240	0.95187381
44	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.90820830
45	Linoleic acid metabolism_Homo sapiens_hsa00591	0.90488855
46	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.87982151
47	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.87773542
48	Phototransduction_Homo sapiens_hsa04744	0.86545281
49	Purine metabolism_Homo sapiens_hsa00230	0.82837333
50	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.78061627
51	Collecting duct acid secretion_Homo sapiens_hsa04966	0.77362870
52	Huntingtons disease_Homo sapiens_hsa05016	0.77167346
53	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.76747394
54	Antigen processing and presentation_Homo sapiens_hsa04612	0.75437883
55	Caffeine metabolism_Homo sapiens_hsa00232	0.72761656
56	Legionellosis_Homo sapiens_hsa05134	0.72000990
57	Propanoate metabolism_Homo sapiens_hsa00640	0.70725535
58	Steroid biosynthesis_Homo sapiens_hsa00100	0.69526655
59	Ribosome_Homo sapiens_hsa03010	0.67143963
60	Base excision repair_Homo sapiens_hsa03410	0.65083715
61	p53 signaling pathway_Homo sapiens_hsa04115	0.64401119
62	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.62751417
63	Ether lipid metabolism_Homo sapiens_hsa00565	0.62419954
64	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.61496918
65	Regulation of autophagy_Homo sapiens_hsa04140	0.60901376
66	mRNA surveillance pathway_Homo sapiens_hsa03015	0.60639444
67	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.59752523
68	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.56883061
69	Alcoholism_Homo sapiens_hsa05034	0.56601863
70	Viral carcinogenesis_Homo sapiens_hsa05203	0.56585683
71	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.56378165
72	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.51973833
73	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.51868240
74	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.49210344
75	Herpes simplex infection_Homo sapiens_hsa05168	0.48255594
76	Tryptophan metabolism_Homo sapiens_hsa00380	0.47288605
77	Alzheimers disease_Homo sapiens_hsa05010	0.46980645
78	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.45434060
79	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.42128698
80	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.41096103
81	Viral myocarditis_Homo sapiens_hsa05416	0.40030956
82	Peroxisome_Homo sapiens_hsa04146	0.37629906
83	Butanoate metabolism_Homo sapiens_hsa00650	0.36985513
84	Metabolic pathways_Homo sapiens_hsa01100	0.35008162
85	Cell cycle_Homo sapiens_hsa04110	0.34738709
86	HTLV-I infection_Homo sapiens_hsa05166	0.32795940
87	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.31996602
88	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.29172228
89	Arginine and proline metabolism_Homo sapiens_hsa00330	0.27891971
90	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.27341257
91	TNF signaling pathway_Homo sapiens_hsa04668	0.23218301
92	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.22996576
93	Lysine degradation_Homo sapiens_hsa00310	0.20972603
94	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.20800730
95	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.20404265
96	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.20103199
97	Fatty acid elongation_Homo sapiens_hsa00062	0.18947928
98	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.18374047
99	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.17335709
100	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.13591093

RPL29P14

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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