ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.43171779
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.17514745
3	cytidine deamination (GO:0009972)	4.51581366
4	cytidine metabolic process (GO:0046087)	4.51581366
5	cytidine catabolic process (GO:0006216)	4.51581366
6	positive regulation of natural killer cell differentiation (GO:0032825)	3.92206858
7	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.78964371
8	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.73714264
9	proteasome assembly (GO:0043248)	3.72589409
10	base-excision repair, AP site formation (GO:0006285)	3.71101031
11	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.63347068
12	ATP synthesis coupled proton transport (GO:0015986)	3.59769185
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.59769185
14	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.57786556
15	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.57786556
16	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.55333026
17	actin nucleation (GO:0045010)	3.49115484
18	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.45114925
19	ribosomal small subunit assembly (GO:0000028)	3.42601446
20	iron-sulfur cluster assembly (GO:0016226)	3.38418768
21	metallo-sulfur cluster assembly (GO:0031163)	3.38418768
22	positive regulation of interleukin-17 production (GO:0032740)	3.36137078
23	negative regulation of mast cell activation (GO:0033004)	3.35881034
24	negative T cell selection (GO:0043383)	3.31989608
25	response to interferon-beta (GO:0035456)	3.30658938
26	regulation of chronic inflammatory response (GO:0002676)	3.30339565
27	regulation of cellular amino acid metabolic process (GO:0006521)	3.29494849
28	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.28443938
29	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.28407635
30	response to pheromone (GO:0019236)	3.24550227
31	regulation of regulatory T cell differentiation (GO:0045589)	3.24480429
32	mannosylation (GO:0097502)	3.24106414
33	regulation of B cell receptor signaling pathway (GO:0050855)	3.23644102
34	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.21886929
35	mast cell activation (GO:0045576)	3.20560740
36	sequestering of actin monomers (GO:0042989)	3.19746285
37	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.19480006
38	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.17360095
39	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.15813098
40	negative regulation of T cell apoptotic process (GO:0070233)	3.12327900
41	positive T cell selection (GO:0043368)	3.11385096
42	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.09744697
43	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.09744697
44	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.09744697
45	positive regulation of defense response to virus by host (GO:0002230)	3.08492023
46	cellular response to interleukin-15 (GO:0071350)	3.08433398
47	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.08338693
48	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.08338693
49	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.07340177
50	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.05117194
51	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.03530760
52	S-adenosylmethionine metabolic process (GO:0046500)	3.02791390
53	regulation of T cell mediated cytotoxicity (GO:0001914)	3.02430152
54	regulation of leukocyte mediated cytotoxicity (GO:0001910)	3.02303030
55	sleep (GO:0030431)	2.97974419
56	positive thymic T cell selection (GO:0045059)	2.97486839
57	mast cell activation involved in immune response (GO:0002279)	2.96767590
58	mast cell degranulation (GO:0043303)	2.96767590
59	GPI anchor biosynthetic process (GO:0006506)	2.96545571
60	GPI anchor metabolic process (GO:0006505)	2.94700221
61	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.94263992
62	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.94165959
63	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.93859002
64	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.93701578
65	purine deoxyribonucleotide catabolic process (GO:0009155)	2.92622412
66	regulation of interleukin-8 secretion (GO:2000482)	2.88893229
67	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.88215083
68	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.88215083
69	regulation of T cell receptor signaling pathway (GO:0050856)	2.87596155
70	platelet dense granule organization (GO:0060155)	2.86317970
71	ubiquinone biosynthetic process (GO:0006744)	2.85732312
72	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.84364842
73	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.83318907
74	regulation of activation of Janus kinase activity (GO:0010533)	2.82268642
75	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.80469515
76	positive regulation of cell killing (GO:0031343)	2.77537714
77	positive regulation of prostaglandin secretion (GO:0032308)	2.76525900
78	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	2.74557397
79	regulation of natural killer cell mediated immunity (GO:0002715)	2.74557397
80	deoxyribonucleotide catabolic process (GO:0009264)	2.74352925
81	negative regulation of ligase activity (GO:0051352)	2.74038931
82	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.74038931
83	protein neddylation (GO:0045116)	2.73893135
84	regulation of natural killer cell differentiation (GO:0032823)	2.72839760
85	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.72455610
86	water-soluble vitamin biosynthetic process (GO:0042364)	2.71551461
87	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.71525864
88	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.70017546
89	regulation of isotype switching to IgG isotypes (GO:0048302)	2.69736990
90	positive regulation of interleukin-8 secretion (GO:2000484)	2.68475244
91	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.67361692
92	regulation of cell killing (GO:0031341)	2.65461928
93	kynurenine metabolic process (GO:0070189)	2.64676827
94	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.63153063
95	electron transport chain (GO:0022900)	2.62885733
96	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.62308493
97	positive regulation of B cell differentiation (GO:0045579)	2.61783704
98	piRNA metabolic process (GO:0034587)	2.60052061
99	respiratory electron transport chain (GO:0022904)	2.60009578
100	L-methionine biosynthetic process (GO:0071265)	2.59941604

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.07479897
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.72449924
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.54072583
4	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.29803746
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.21332017
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.12914169
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.11057254
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.00883147
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.90243386
10	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.73891593
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.65972172
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.61089877
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.59855766
14	VDR_22108803_ChIP-Seq_LS180_Human	2.49959523
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.47403607
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.41444066
17	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.39790517
18	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.30172798
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.26258557
20	ELK1_19687146_ChIP-ChIP_HELA_Human	2.17185103
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.16171572
22	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.12264569
23	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.10521320
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.95605674
25	MYB_26560356_Chip-Seq_TH2_Human	1.93372601
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.93062222
27	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.82720038
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.75228747
29	GATA3_26560356_Chip-Seq_TH2_Human	1.75195512
30	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.63195069
31	AR_20517297_ChIP-Seq_VCAP_Human	1.60061502
32	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.53879908
33	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.51885987
34	IGF1R_20145208_ChIP-Seq_DFB_Human	1.50877605
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.46578826
36	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.46375960
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.46367801
38	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.45715301
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.45012268
40	RUNX_20019798_ChIP-Seq_JUKART_Human	1.44134510
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.39497393
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.39343424
43	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.39343424
44	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.36545806
45	EWS_26573619_Chip-Seq_HEK293_Human	1.36284859
46	GATA3_27048872_Chip-Seq_THYMUS_Human	1.35666871
47	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.35255505
48	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.31893130
49	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.31889000
50	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.31750294
51	FUS_26573619_Chip-Seq_HEK293_Human	1.24301515
52	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.23744213
53	ER_23166858_ChIP-Seq_MCF-7_Human	1.23699240
54	NANOG_20526341_ChIP-Seq_ESCs_Human	1.22701368
55	TAF15_26573619_Chip-Seq_HEK293_Human	1.21005773
56	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.19953544
57	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.18059931
58	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.16589423
59	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.16254374
60	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.15947276
61	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.15496439
62	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.14911952
63	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.14044366
64	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.11392814
65	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.11248930
66	IRF1_19129219_ChIP-ChIP_H3396_Human	1.09886038
67	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.09550099
68	CBP_20019798_ChIP-Seq_JUKART_Human	1.09297479
69	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.09297479
70	ERG_20517297_ChIP-Seq_VCAP_Human	1.09176491
71	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.09071211
72	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08119516
73	SOX2_19829295_ChIP-Seq_ESCs_Human	1.07706915
74	NANOG_19829295_ChIP-Seq_ESCs_Human	1.07706915
75	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.07002086
76	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.06534641
77	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.04403223
78	CIITA_25753668_ChIP-Seq_RAJI_Human	1.04319391
79	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04029407
80	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.02554061
81	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.02203047
82	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.01601860
83	BCL6_27268052_Chip-Seq_Bcells_Human	0.98012658
84	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97369183
85	P300_19829295_ChIP-Seq_ESCs_Human	0.95243836
86	MYC_19829295_ChIP-Seq_ESCs_Human	0.94970697
87	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.94016100
88	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.93941322
89	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.93648529
90	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.92291203
91	MYB_26560356_Chip-Seq_TH1_Human	0.92134918
92	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.92116849
93	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.91649402
94	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.91124508
95	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.91123344
96	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.90485163
97	NCOR_22424771_ChIP-Seq_293T_Human	0.90449161
98	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.90323985
99	GBX2_23144817_ChIP-Seq_PC3_Human	0.89918648
100	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.89755091

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.46612578
2	MP0001835_abnormal_antigen_presentation	3.17468467
3	MP0003763_abnormal_thymus_physiology	2.81205646
4	MP0009785_altered_susceptibility_to	2.75969850
5	MP0002102_abnormal_ear_morphology	2.39643422
6	MP0002166_altered_tumor_susceptibility	2.33474878
7	MP0008875_abnormal_xenobiotic_pharmacok	2.30894962
8	MP0000685_abnormal_immune_system	2.26909624
9	MP0003195_calcinosis	2.21738066
10	MP0003786_premature_aging	2.14899751
11	MP0005000_abnormal_immune_tolerance	2.11780818
12	MP0002148_abnormal_hypersensitivity_rea	2.11248952
13	MP0001800_abnormal_humoral_immune	2.06404078
14	MP0006072_abnormal_retinal_apoptosis	2.05696829
15	MP0005075_abnormal_melanosome_morpholog	2.02526926
16	MP0003724_increased_susceptibility_to	1.98715993
17	MP0002006_tumorigenesis	1.94306634
18	MP0003011_delayed_dark_adaptation	1.93853735
19	MP0001873_stomach_inflammation	1.89819097
20	MP0002723_abnormal_immune_serum	1.89203356
21	MP0004147_increased_porphyrin_level	1.88124512
22	MP0008872_abnormal_physiological_respon	1.80478013
23	MP0001790_abnormal_immune_system	1.70340551
24	MP0005387_immune_system_phenotype	1.70340551
25	MP0002420_abnormal_adaptive_immunity	1.69137860
26	MP0001819_abnormal_immune_cell	1.65363901
27	MP0002138_abnormal_hepatobiliary_system	1.63996521
28	MP0005084_abnormal_gallbladder_morpholo	1.62910929
29	MP0003252_abnormal_bile_duct	1.61081155
30	MP0000372_irregular_coat_pigmentation	1.60423167
31	MP0005025_abnormal_response_to	1.59575669
32	MP0002452_abnormal_antigen_presenting	1.56323322
33	MP0009333_abnormal_splenocyte_physiolog	1.54995703
34	MP0001542_abnormal_bone_strength	1.52764652
35	MP0000465_gastrointestinal_hemorrhage	1.50864983
36	MP0003646_muscle_fatigue	1.50052912
37	MP0001501_abnormal_sleep_pattern	1.49551964
38	MP0002933_joint_inflammation	1.47952844
39	MP0005360_urolithiasis	1.46305232
40	MP0002736_abnormal_nociception_after	1.45510917
41	MP0010386_abnormal_urinary_bladder	1.42803046
42	MP0003436_decreased_susceptibility_to	1.41870645
43	MP0002405_respiratory_system_inflammati	1.41387647
44	MP0005551_abnormal_eye_electrophysiolog	1.35301649
45	MP0002876_abnormal_thyroid_physiology	1.30107181
46	MP0005645_abnormal_hypothalamus_physiol	1.28762065
47	MP0006054_spinal_hemorrhage	1.27727068
48	MP0005646_abnormal_pituitary_gland	1.27515056
49	MP0001968_abnormal_touch/_nociception	1.26975470
50	MP0000716_abnormal_immune_system	1.26975090
51	MP0002398_abnormal_bone_marrow	1.26535843
52	MP0003045_fibrosis	1.24732015
53	MP0000689_abnormal_spleen_morphology	1.22899097
54	MP0001845_abnormal_inflammatory_respons	1.22796525
55	MP0008877_abnormal_DNA_methylation	1.22293064
56	MP0010155_abnormal_intestine_physiology	1.22247555
57	MP0003866_abnormal_defecation	1.22147068
58	MP0005253_abnormal_eye_physiology	1.21675704
59	MP0002837_dystrophic_cardiac_calcinosis	1.21574058
60	MP0001764_abnormal_homeostasis	1.21424529
61	MP0001905_abnormal_dopamine_level	1.17487720
62	MP0008438_abnormal_cutaneous_collagen	1.15867442
63	MP0001919_abnormal_reproductive_system	1.15611189
64	MP0009764_decreased_sensitivity_to	1.14547235
65	MP0001986_abnormal_taste_sensitivity	1.14423030
66	MP0005389_reproductive_system_phenotype	1.12218531
67	MP0002722_abnormal_immune_system	1.10096041
68	MP0005410_abnormal_fertilization	1.09343167
69	MP0003950_abnormal_plasma_membrane	1.08389882
70	MP0003283_abnormal_digestive_organ	1.07349173
71	MP0001533_abnormal_skeleton_physiology	1.07093299
72	MP0002277_abnormal_respiratory_mucosa	1.06858587
73	MP0001853_heart_inflammation	1.06321320
74	MP0002638_abnormal_pupillary_reflex	1.00136687
75	MP0008469_abnormal_protein_level	0.99774198
76	MP0003880_abnormal_central_pattern	0.96889788
77	MP0002429_abnormal_blood_cell	0.95346769
78	MP0002419_abnormal_innate_immunity	0.94144420
79	MP0001243_abnormal_dermal_layer	0.92205313
80	MP0005503_abnormal_tendon_morphology	0.91594460
81	MP0000703_abnormal_thymus_morphology	0.91540644
82	MP0005085_abnormal_gallbladder_physiolo	0.90519181
83	MP0010368_abnormal_lymphatic_system	0.88810980
84	MP0005365_abnormal_bile_salt	0.85119616
85	MP0006276_abnormal_autonomic_nervous	0.84513999
86	MP0004145_abnormal_muscle_electrophysio	0.83299852
87	MP0006082_CNS_inflammation	0.82650529
88	MP0005332_abnormal_amino_acid	0.81320217
89	MP0008058_abnormal_DNA_repair	0.80172855
90	MP0001765_abnormal_ion_homeostasis	0.79987208
91	MP0008995_early_reproductive_senescence	0.79149051
92	MP0005636_abnormal_mineral_homeostasis	0.77789583
93	MP0002019_abnormal_tumor_incidence	0.76973304
94	MP0001119_abnormal_female_reproductive	0.76080852
95	MP0009763_increased_sensitivity_to	0.74798668
96	MP0003137_abnormal_impulse_conducting	0.74462818
97	MP0009643_abnormal_urine_homeostasis	0.74448140
98	MP0003279_aneurysm	0.73950929
99	MP0008775_abnormal_heart_ventricle	0.73849351
100	MP0002234_abnormal_pharynx_morphology	0.73333071

Predicted human phenotypes

Rank	Gene Set	Z-score
1	IgG deficiency (HP:0004315)	4.64826116
2	Aplastic anemia (HP:0001915)	4.46839460
3	Elevated erythrocyte sedimentation rate (HP:0003565)	3.90833997
4	Hypoproteinemia (HP:0003075)	3.65674033
5	Mitochondrial inheritance (HP:0001427)	3.47612122
6	Severe combined immunodeficiency (HP:0004430)	3.45126216
7	Acute necrotizing encephalopathy (HP:0006965)	3.33350475
8	Congenital stationary night blindness (HP:0007642)	3.33065876
9	Abnormality of T cell number (HP:0011839)	3.30202880
10	3-Methylglutaconic aciduria (HP:0003535)	3.24302457
11	T lymphocytopenia (HP:0005403)	3.21757543
12	Reduced antithrombin III activity (HP:0001976)	3.14433252
13	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.10523390
14	Abolished electroretinogram (ERG) (HP:0000550)	3.08896412
15	Stomatitis (HP:0010280)	3.08781518
16	Increased CSF lactate (HP:0002490)	3.04584893
17	Hepatocellular necrosis (HP:0001404)	3.04313191
18	Pancreatic cysts (HP:0001737)	3.03668636
19	Abnormal mitochondria in muscle tissue (HP:0008316)	2.99925847
20	Type I transferrin isoform profile (HP:0003642)	2.95345459
21	Abnormal protein glycosylation (HP:0012346)	2.90161405
22	Abnormal glycosylation (HP:0012345)	2.90161405
23	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.90161405
24	Abnormal protein N-linked glycosylation (HP:0012347)	2.90161405
25	Attenuation of retinal blood vessels (HP:0007843)	2.90072778
26	Increased hepatocellular lipid droplets (HP:0006565)	2.89496281
27	Abnormality of the prostate (HP:0008775)	2.88335795
28	Acute encephalopathy (HP:0006846)	2.75002172
29	Progressive macrocephaly (HP:0004481)	2.72723877
30	Abnormal rod and cone electroretinograms (HP:0008323)	2.67983060
31	Hepatic necrosis (HP:0002605)	2.67511122
32	Increased IgM level (HP:0003496)	2.66676609
33	Abnormality of B cell number (HP:0010975)	2.66630340
34	Pancytopenia (HP:0001876)	2.60394623
35	Renal Fanconi syndrome (HP:0001994)	2.59171272
36	Pancreatic fibrosis (HP:0100732)	2.55142673
37	Lipid accumulation in hepatocytes (HP:0006561)	2.54655913
38	True hermaphroditism (HP:0010459)	2.54413418
39	Type II lissencephaly (HP:0007260)	2.52302160
40	Thyroiditis (HP:0100646)	2.51787095
41	Exertional dyspnea (HP:0002875)	2.51675791
42	Increased corneal curvature (HP:0100692)	2.51389330
43	Keratoconus (HP:0000563)	2.51389330
44	Combined immunodeficiency (HP:0005387)	2.50722270
45	Optic disc pallor (HP:0000543)	2.47830778
46	Abnormality of the renal cortex (HP:0011035)	2.43324542
47	Prostate neoplasm (HP:0100787)	2.43251069
48	Abnormality of T cells (HP:0002843)	2.43018360
49	Autoimmune hemolytic anemia (HP:0001890)	2.40143748
50	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.36576039
51	Increased intramyocellular lipid droplets (HP:0012240)	2.33560389
52	Aplasia/hypoplasia of the uterus (HP:0008684)	2.32177473
53	Decreased central vision (HP:0007663)	2.31689327
54	Molar tooth sign on MRI (HP:0002419)	2.31189996
55	Abnormality of midbrain morphology (HP:0002418)	2.31189996
56	Hypoplasia of the uterus (HP:0000013)	2.30930353
57	Increased serum lactate (HP:0002151)	2.30710845
58	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.29111846
59	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.29111846
60	Renal cortical cysts (HP:0000803)	2.28250151
61	Nephronophthisis (HP:0000090)	2.27472271
62	Stomach cancer (HP:0012126)	2.26074764
63	Methylmalonic acidemia (HP:0002912)	2.22357178
64	Lactic acidosis (HP:0003128)	2.18795090
65	Abnormality of eosinophils (HP:0001879)	2.18553856
66	Retinal dysplasia (HP:0007973)	2.18521883
67	Neonatal respiratory distress (HP:0002643)	2.16786363
68	Abnormal drinking behavior (HP:0030082)	2.15187763
69	Polydipsia (HP:0001959)	2.15187763
70	B lymphocytopenia (HP:0010976)	2.14072618
71	Abnormality of macular pigmentation (HP:0008002)	2.12577856
72	Cerebral edema (HP:0002181)	2.12561467
73	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.06323724
74	Chronic diarrhea (HP:0002028)	2.05326029
75	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.02121395
76	Lethargy (HP:0001254)	1.98197053
77	Constricted visual fields (HP:0001133)	1.98065836
78	Pustule (HP:0200039)	1.95859509
79	Methylmalonic aciduria (HP:0012120)	1.95348272
80	Abnormality of the renal medulla (HP:0100957)	1.93473071
81	Dyschromatopsia (HP:0007641)	1.88252458
82	Congenital, generalized hypertrichosis (HP:0004540)	1.86972463
83	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.86326894
84	Dicarboxylic aciduria (HP:0003215)	1.86326894
85	Oral leukoplakia (HP:0002745)	1.85556992
86	Myositis (HP:0100614)	1.85357071
87	Polyuria (HP:0000103)	1.83858693
88	Abnormal albumin level (HP:0012116)	1.83595437
89	Hypoalbuminemia (HP:0003073)	1.83595437
90	Abnormality of the pons (HP:0007361)	1.82613913
91	Glycosuria (HP:0003076)	1.82012887
92	Abnormality of urine glucose concentration (HP:0011016)	1.82012887
93	Increased muscle lipid content (HP:0009058)	1.81908227
94	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.80446717
95	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.80329467
96	Medial flaring of the eyebrow (HP:0010747)	1.78196768
97	Respiratory failure (HP:0002878)	1.77317156
98	Abnormal number of erythroid precursors (HP:0012131)	1.76425567
99	Abnormality of T cell physiology (HP:0011840)	1.75156290
100	Tubular atrophy (HP:0000092)	1.74349538

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.93134343
2	TXK	3.65923352
3	VRK2	3.60481411
4	KDR	3.25790825
5	TESK2	3.23512486
6	NUAK1	3.04629404
7	TLK1	2.74530781
8	BCKDK	2.69945218
9	ZAK	2.45954243
10	TAOK3	2.30557672
11	SCYL2	2.27276781
12	ADRBK2	2.22675886
13	LIMK1	1.91139765
14	GRK6	1.87839110
15	CDK19	1.82306654
16	MAP3K12	1.75195198
17	TESK1	1.72790170
18	PINK1	1.69851593
19	VRK1	1.69351850
20	MYLK	1.67132582
21	MUSK	1.66337006
22	TEC	1.61202946
23	GRK1	1.59459615
24	MST4	1.53687370
25	FLT3	1.50077637
26	DAPK1	1.47973028
27	KIT	1.41086202
28	ZAP70	1.40941470
29	ITK	1.30837559
30	STK16	1.28444435
31	MAP4K1	1.25342432
32	EIF2AK3	1.23964665
33	FRK	1.12217971
34	IKBKE	1.11535972
35	SYK	1.09177465
36	BUB1	1.05391622
37	DAPK2	1.03066032
38	BMPR2	1.01193502
39	TRIM28	1.00382866
40	IKBKB	0.99939063
41	ERBB3	0.98894549
42	BTK	0.98172368
43	MAPKAPK3	0.95713714
44	TBK1	0.86191134
45	FES	0.84015200
46	TIE1	0.82913490
47	RPS6KA5	0.79123352
48	CAMKK2	0.78851661
49	PASK	0.78699552
50	PRKCQ	0.76903785
51	ACVR1B	0.75825526
52	ADRBK1	0.74673862
53	LCK	0.73383349
54	JAK3	0.72358419
55	TAF1	0.66838662
56	WNK4	0.64594880
57	INSRR	0.61358589
58	OXSR1	0.61252438
59	CSNK1G3	0.60124687
60	DAPK3	0.58425032
61	PIM2	0.57501560
62	LYN	0.57332817
63	MAPKAPK5	0.57113574
64	BMPR1B	0.57037628
65	SRPK1	0.57037261
66	NME1	0.56832075
67	MAP3K14	0.55876394
68	GRK7	0.52447797
69	IGF1R	0.52119404
70	EIF2AK2	0.51673869
71	WNK3	0.49835324
72	GRK5	0.49826500
73	ROCK1	0.49486035
74	CSNK1G2	0.46967811
75	ILK	0.44860533
76	HCK	0.44502004
77	BCR	0.44237530
78	CSF1R	0.44106186
79	RPS6KA4	0.43906155
80	CSNK1G1	0.42649232
81	CLK1	0.41608523
82	MAP2K2	0.41321380
83	MAP2K6	0.40670298
84	MATK	0.37965053
85	PHKG1	0.36162558
86	PHKG2	0.36162558
87	ABL1	0.35934241
88	PRKCE	0.35507068
89	JAK1	0.34309816
90	CSNK1A1L	0.33576355
91	TRPM7	0.32363282
92	CDK8	0.31435553
93	STK10	0.31246538
94	PRKCA	0.30069119
95	MAPK13	0.27957113
96	PLK3	0.27952811
97	PIM1	0.27749941
98	PTK2B	0.27017185
99	INSR	0.26413606
100	PIK3CG	0.26145834

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.54316409
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.76839483
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.81253152
4	Allograft rejection_Homo sapiens_hsa05330	2.57256511
5	Asthma_Homo sapiens_hsa05310	2.52237110
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.50669767
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.48165098
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.48040225
9	Parkinsons disease_Homo sapiens_hsa05012	2.34826429
10	Ribosome_Homo sapiens_hsa03010	2.27962604
11	RNA polymerase_Homo sapiens_hsa03020	2.20336055
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.09766055
13	Antigen processing and presentation_Homo sapiens_hsa04612	2.02611154
14	Type I diabetes mellitus_Homo sapiens_hsa04940	1.97924631
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.91084150
16	Protein export_Homo sapiens_hsa03060	1.88533821
17	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.85194846
18	Phototransduction_Homo sapiens_hsa04744	1.73198835
19	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.67190909
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.56076749
21	Homologous recombination_Homo sapiens_hsa03440	1.53586471
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.49523618
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.41140004
24	Huntingtons disease_Homo sapiens_hsa05016	1.34668778
25	Alzheimers disease_Homo sapiens_hsa05010	1.33764165
26	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.26500686
27	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.25790385
28	Basal transcription factors_Homo sapiens_hsa03022	1.25037473
29	Rheumatoid arthritis_Homo sapiens_hsa05323	1.19270224
30	Base excision repair_Homo sapiens_hsa03410	1.18298319
31	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.15788784
32	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.14441420
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.13378028
34	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.12546516
35	RNA degradation_Homo sapiens_hsa03018	1.12497652
36	Linoleic acid metabolism_Homo sapiens_hsa00591	1.12494726
37	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.10776540
38	Peroxisome_Homo sapiens_hsa04146	1.09484227
39	Sulfur metabolism_Homo sapiens_hsa00920	1.08605012
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.08107842
41	One carbon pool by folate_Homo sapiens_hsa00670	1.07315915
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.01802250
43	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.00588921
44	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.98895896
45	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.97059575
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.95737628
47	Caffeine metabolism_Homo sapiens_hsa00232	0.95089637
48	Tryptophan metabolism_Homo sapiens_hsa00380	0.90288516
49	Propanoate metabolism_Homo sapiens_hsa00640	0.89020080
50	Fatty acid elongation_Homo sapiens_hsa00062	0.87781391
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.87646379
52	Fanconi anemia pathway_Homo sapiens_hsa03460	0.86031330
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85930433
54	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.85359336
55	Cardiac muscle contraction_Homo sapiens_hsa04260	0.81930384
56	Retinol metabolism_Homo sapiens_hsa00830	0.78626478
57	Olfactory transduction_Homo sapiens_hsa04740	0.78043988
58	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.76779506
59	Purine metabolism_Homo sapiens_hsa00230	0.76375647
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.75716330
61	Malaria_Homo sapiens_hsa05144	0.75333186
62	Regulation of autophagy_Homo sapiens_hsa04140	0.75324746
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.74811348
64	Viral myocarditis_Homo sapiens_hsa05416	0.73056195
65	Selenocompound metabolism_Homo sapiens_hsa00450	0.72105423
66	Butanoate metabolism_Homo sapiens_hsa00650	0.71459818
67	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.71315119
68	Nucleotide excision repair_Homo sapiens_hsa03420	0.69478534
69	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.69315198
70	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.65768175
71	Spliceosome_Homo sapiens_hsa03040	0.65225281
72	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.60955766
73	Metabolic pathways_Homo sapiens_hsa01100	0.58505515
74	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.56413850
75	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.56074974
76	Ether lipid metabolism_Homo sapiens_hsa00565	0.52519831
77	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.52255216
78	Herpes simplex infection_Homo sapiens_hsa05168	0.52015931
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.51466771
80	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.51302220
81	Measles_Homo sapiens_hsa05162	0.50144957
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.47292808
83	Salivary secretion_Homo sapiens_hsa04970	0.46970584
84	Mismatch repair_Homo sapiens_hsa03430	0.45610198
85	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.43355434
86	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.43078701
87	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.42030226
88	RNA transport_Homo sapiens_hsa03013	0.41929743
89	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.41404614
90	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.39954450
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.38187233
92	DNA replication_Homo sapiens_hsa03030	0.35351158
93	Shigellosis_Homo sapiens_hsa05131	0.34847150
94	Leishmaniasis_Homo sapiens_hsa05140	0.34262990
95	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.33465827
96	Taste transduction_Homo sapiens_hsa04742	0.31490902
97	Glutathione metabolism_Homo sapiens_hsa00480	0.24051309
98	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.23055147
99	Sulfur relay system_Homo sapiens_hsa04122	0.22186443
100	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.21131085

RPL29P19

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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