RPL29P22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of activation of Janus kinase activity (GO:0010533)8.27340643
2negative regulation of mast cell activation (GO:0033004)7.63274706
3negative regulation of phagocytosis (GO:0050765)7.33612475
4positive regulation of phosphoprotein phosphatase activity (GO:0032516)7.28427086
5ATP synthesis coupled proton transport (GO:0015986)6.05788854
6energy coupled proton transport, down electrochemical gradient (GO:0015985)6.05788854
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.89189621
8regulation of B cell receptor signaling pathway (GO:0050855)5.76003126
9positive regulation of natural killer cell differentiation (GO:0032825)5.28152761
10negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.80478188
11peptidyl-histidine modification (GO:0018202)4.80291414
12negative regulation of B cell proliferation (GO:0030889)4.67657223
13maturation of 5.8S rRNA (GO:0000460)4.52811947
14negative regulation of alpha-beta T cell activation (GO:0046636)4.48459472
15autophagic vacuole fusion (GO:0000046)4.40694601
16proteasome assembly (GO:0043248)4.35788332
17positive regulation of interleukin-17 production (GO:0032740)4.12560627
18ribosomal large subunit biogenesis (GO:0042273)3.93438517
19regulation of chronic inflammatory response (GO:0002676)3.91179699
20ribosomal small subunit biogenesis (GO:0042274)3.89846454
21viral transcription (GO:0019083)3.82858782
22regulation of natural killer cell differentiation (GO:0032823)3.79335639
23regulation of T cell receptor signaling pathway (GO:0050856)3.74431309
24translational termination (GO:0006415)3.72999022
25water-soluble vitamin biosynthetic process (GO:0042364)3.65789460
26organelle membrane fusion (GO:0090174)3.65608003
27regulation of mast cell degranulation (GO:0043304)3.58169971
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.54978744
29NADH dehydrogenase complex assembly (GO:0010257)3.54978744
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.54978744
31SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.52251099
32regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.52023745
33negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.50362764
34DNA deamination (GO:0045006)3.44170249
35formation of translation preinitiation complex (GO:0001731)3.42797807
36cotranslational protein targeting to membrane (GO:0006613)3.40739174
37protein targeting to ER (GO:0045047)3.39432764
38protein localization to endoplasmic reticulum (GO:0070972)3.35298039
39regulation of cellular senescence (GO:2000772)3.33942080
40exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.33085150
41negative regulation of B cell activation (GO:0050869)3.32900127
42protein complex biogenesis (GO:0070271)3.32179388
43positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.31071642
44regulation of mast cell activation involved in immune response (GO:0033006)3.26421782
45ATP biosynthetic process (GO:0006754)3.23719907
46mitochondrial respiratory chain complex assembly (GO:0033108)3.22246016
47positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.21880268
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.18918284
49translational initiation (GO:0006413)3.18568370
50ribosomal small subunit assembly (GO:0000028)3.17889574
51nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.15935624
52termination of RNA polymerase I transcription (GO:0006363)3.15662558
53establishment of protein localization to endoplasmic reticulum (GO:0072599)3.15252877
54translational elongation (GO:0006414)3.14661149
55negative regulation of leukocyte migration (GO:0002686)3.13609027
56negative regulation of macrophage differentiation (GO:0045650)3.11049011
57transcription elongation from RNA polymerase I promoter (GO:0006362)3.10108064
58translation (GO:0006412)3.07330927
59negative regulation of T cell differentiation in thymus (GO:0033085)3.06993924
60electron transport chain (GO:0022900)3.05743092
61regulation of mitochondrial translation (GO:0070129)3.03665050
62positive regulation of interferon-gamma production (GO:0032729)3.02480473
63regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.01552898
64positive regulation of phosphatase activity (GO:0010922)3.01051860
65positive regulation of chemokine biosynthetic process (GO:0045080)3.00426797
66oxidative phosphorylation (GO:0006119)2.99929144
67respiratory electron transport chain (GO:0022904)2.99140876
68organic cation transport (GO:0015695)2.97992610
69establishment of protein localization to mitochondrial membrane (GO:0090151)2.90940691
70positive regulation of interleukin-10 production (GO:0032733)2.90851498
71purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.90020097
72signal peptide processing (GO:0006465)2.89455008
73purine nucleoside triphosphate biosynthetic process (GO:0009145)2.88514386
74positive regulation of natural killer cell activation (GO:0032816)2.87212238
75maturation of SSU-rRNA (GO:0030490)2.84827758
76regulation of cellular respiration (GO:0043457)2.84694079
77regulation of B cell proliferation (GO:0030888)2.81836087
78viral mRNA export from host cell nucleus (GO:0046784)2.81346547
79positive regulation of prostaglandin secretion (GO:0032308)2.80454364
80regulation of mast cell activation (GO:0033003)2.79442167
81response to interferon-beta (GO:0035456)2.74934610
82cellular response to interferon-beta (GO:0035458)2.74508794
83viral life cycle (GO:0019058)2.73451034
84transcription initiation from RNA polymerase I promoter (GO:0006361)2.71832335
85regulation of T cell mediated cytotoxicity (GO:0001914)2.71625936
86cellular protein complex disassembly (GO:0043624)2.71601841
87kynurenine metabolic process (GO:0070189)2.70200098
88mast cell activation (GO:0045576)2.66234114
89termination of RNA polymerase III transcription (GO:0006386)2.65497320
90transcription elongation from RNA polymerase III promoter (GO:0006385)2.65497320
91regulation of interferon-gamma biosynthetic process (GO:0045072)2.64851942
92positive regulation of T cell mediated cytotoxicity (GO:0001916)2.61288598
93positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.59827028
94regulation of cellular amino acid metabolic process (GO:0006521)2.58308774
95transcription from RNA polymerase I promoter (GO:0006360)2.58251777
96positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.56892912
97positive regulation of natural killer cell mediated immunity (GO:0002717)2.56199064
98phosphatidylinositol acyl-chain remodeling (GO:0036149)2.56062399
99negative regulation of peptidyl-tyrosine phosphorylation (GO:0050732)2.52020222
100histone mRNA metabolic process (GO:0008334)2.51352906

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.74236057
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.42725044
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.20377531
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.13301559
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.75243403
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.72277633
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.32894749
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.91424160
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.88387387
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.87814992
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.80839716
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.73894529
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.72773342
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.72478033
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.62762855
16ELK1_19687146_ChIP-ChIP_HELA_Human2.46167690
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32394507
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.29954181
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.27920593
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.04378748
21VDR_23849224_ChIP-Seq_CD4+_Human2.00600623
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.99250146
23MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95365867
24FOXP3_21729870_ChIP-Seq_TREG_Human1.94158296
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.87444015
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79539637
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.79312969
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77356343
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74301581
30GATA3_26560356_Chip-Seq_TH2_Human1.73585573
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.70285599
32EGR1_23403033_ChIP-Seq_LIVER_Mouse1.62384269
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.58893593
34IGF1R_20145208_ChIP-Seq_DFB_Human1.58490771
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55989038
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.44494408
37TTF2_22483619_ChIP-Seq_HELA_Human1.43766725
38ZNF274_21170338_ChIP-Seq_K562_Hela1.33258673
39VDR_22108803_ChIP-Seq_LS180_Human1.31657948
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.31621193
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.31012208
42TAF15_26573619_Chip-Seq_HEK293_Human1.29526581
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28889397
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27704018
45AR_20517297_ChIP-Seq_VCAP_Human1.26175750
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26046172
47TP53_22573176_ChIP-Seq_HFKS_Human1.24327063
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23233477
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22585766
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21872190
51TAF2_19829295_ChIP-Seq_ESCs_Human1.20191635
52PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.18917701
53ERG_20517297_ChIP-Seq_VCAP_Human1.18704487
54EWS_26573619_Chip-Seq_HEK293_Human1.17034987
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16584038
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.16584038
57MYB_26560356_Chip-Seq_TH2_Human1.15997765
58PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13297856
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12786914
60MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12131327
61SOX2_19829295_ChIP-Seq_ESCs_Human1.11553680
62NANOG_19829295_ChIP-Seq_ESCs_Human1.11553680
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10873377
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10285423
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.05809929
66MYC_18940864_ChIP-ChIP_HL60_Human1.05492180
67SPI1_23547873_ChIP-Seq_NB4_Human1.03650210
68STAT1_20625510_ChIP-Seq_HELA_Human1.01657888
69MYC_19030024_ChIP-ChIP_MESCs_Mouse1.01269294
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01232202
71EGR1_19032775_ChIP-ChIP_M12_Human1.01159560
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99843881
73FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99489586
74ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99300262
75FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98983313
76BCL6_27268052_Chip-Seq_Bcells_Human0.98930746
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98853450
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98609797
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96613283
80SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96416754
81EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95945994
82E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94328173
83FUS_26573619_Chip-Seq_HEK293_Human0.92848853
84DCP1A_22483619_ChIP-Seq_HELA_Human0.92318593
85RAC3_21632823_ChIP-Seq_H3396_Human0.90828394
86NCOR_22424771_ChIP-Seq_293T_Human0.90316857
87IRF1_19129219_ChIP-ChIP_H3396_Human0.90161789
88P300_27268052_Chip-Seq_Bcells_Human0.89789311
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89756832
90RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89592189
91FLI1_27457419_Chip-Seq_LIVER_Mouse0.89182766
92SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88650088
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88632812
94XRN2_22483619_ChIP-Seq_HELA_Human0.88260560
95CTCF_20526341_ChIP-Seq_ESCs_Human0.87429746
96STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87173873
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86707094
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.86486984
99GABP_19822575_ChIP-Seq_HepG2_Human0.86374790
100SOX2_21211035_ChIP-Seq_LN229_Human0.84237379

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue7.57705699
2MP0003806_abnormal_nucleotide_metabolis5.70026122
3MP0001835_abnormal_antigen_presentation4.78895980
4MP0002138_abnormal_hepatobiliary_system2.53535817
5MP0004145_abnormal_muscle_electrophysio2.39413130
6MP0005451_abnormal_body_composition2.30033005
7MP0006036_abnormal_mitochondrial_physio2.23711300
8MP0001873_stomach_inflammation2.09289392
9MP0006082_CNS_inflammation1.97470120
10MP0003786_premature_aging1.96516014
11MP0005075_abnormal_melanosome_morpholog1.90463855
12MP0001790_abnormal_immune_system1.82694181
13MP0005387_immune_system_phenotype1.82694181
14MP0006072_abnormal_retinal_apoptosis1.82079368
15MP0002166_altered_tumor_susceptibility1.81325908
16MP0002332_abnormal_exercise_endurance1.79226435
17MP0008872_abnormal_physiological_respon1.78558777
18MP0001919_abnormal_reproductive_system1.77839300
19MP0004036_abnormal_muscle_relaxation1.75576618
20MP0009379_abnormal_foot_pigmentation1.61554662
21MP0000015_abnormal_ear_pigmentation1.59028469
22MP0002452_abnormal_antigen_presenting1.58346504
23MP0008875_abnormal_xenobiotic_pharmacok1.57633355
24MP0005671_abnormal_response_to1.55913733
25MP0001800_abnormal_humoral_immune1.55664046
26MP0008995_early_reproductive_senescence1.51384763
27MP0005266_abnormal_metabolism1.49810713
28MP0003195_calcinosis1.49465678
29MP0004142_abnormal_muscle_tone1.49257748
30MP0004742_abnormal_vestibular_system1.47301005
31MP0001348_abnormal_lacrimal_gland1.46569038
32MP0003763_abnormal_thymus_physiology1.42884589
33MP0010307_abnormal_tumor_latency1.40933422
34MP0009785_altered_susceptibility_to1.40224002
35MP0002006_tumorigenesis1.39995349
36MP0009764_decreased_sensitivity_to1.38328811
37MP0010368_abnormal_lymphatic_system1.36641876
38MP0005000_abnormal_immune_tolerance1.36020599
39MP0002139_abnormal_hepatobiliary_system1.34228016
40MP0003693_abnormal_embryo_hatching1.33979674
41MP0002837_dystrophic_cardiac_calcinosis1.33690793
42MP0005253_abnormal_eye_physiology1.31529496
43MP0005408_hypopigmentation1.30502193
44MP0001986_abnormal_taste_sensitivity1.29427283
45MP0002723_abnormal_immune_serum1.25114252
46MP0002420_abnormal_adaptive_immunity1.24776276
47MP0001819_abnormal_immune_cell1.22274639
48MP0005410_abnormal_fertilization1.21944012
49MP0003724_increased_susceptibility_to1.21543541
50MP0005389_reproductive_system_phenotype1.19151211
51MP0005174_abnormal_tail_pigmentation1.18979606
52MP0003880_abnormal_central_pattern1.18629530
53MP0000685_abnormal_immune_system1.15674041
54MP0005360_urolithiasis1.14104854
55MP0000343_altered_response_to1.13781524
56MP0002419_abnormal_innate_immunity1.09639382
57MP0005645_abnormal_hypothalamus_physiol1.07668217
58MP0005167_abnormal_blood-brain_barrier1.05741063
59MP0004381_abnormal_hair_follicle1.05164270
60MP0001968_abnormal_touch/_nociception1.04974634
61MP0005166_decreased_susceptibility_to1.04816000
62MP0005025_abnormal_response_to1.03432304
63MP0003186_abnormal_redox_activity1.03346161
64MP0001845_abnormal_inflammatory_respons1.03055595
65MP0003567_abnormal_fetal_cardiomyocyte1.01794230
66MP0005636_abnormal_mineral_homeostasis1.00755669
67MP0003943_abnormal_hepatobiliary_system0.99129428
68MP0008775_abnormal_heart_ventricle0.98928844
69MP0002148_abnormal_hypersensitivity_rea0.97811365
70MP0010386_abnormal_urinary_bladder0.97410896
71MP0002163_abnormal_gland_morphology0.95359340
72MP0002736_abnormal_nociception_after0.91552047
73MP0005646_abnormal_pituitary_gland0.91136441
74MP0005551_abnormal_eye_electrophysiolog0.89207876
75MP0003866_abnormal_defecation0.87933778
76MP0002876_abnormal_thyroid_physiology0.86027510
77MP0003303_peritoneal_inflammation0.85128511
78MP0010155_abnormal_intestine_physiology0.84102504
79MP0001663_abnormal_digestive_system0.83129218
80MP0006054_spinal_hemorrhage0.82311179
81MP0005464_abnormal_platelet_physiology0.81921387
82MP0009384_cardiac_valve_regurgitation0.81309308
83MP0008469_abnormal_protein_level0.79268676
84MP0001324_abnormal_eye_pigmentation0.79252501
85MP0005319_abnormal_enzyme/_coenzyme0.77784762
86MP0001501_abnormal_sleep_pattern0.77660588
87MP0003718_maternal_effect0.75891584
88MP0006035_abnormal_mitochondrial_morpho0.75351660
89MP0001765_abnormal_ion_homeostasis0.75338305
90MP0001502_abnormal_circadian_rhythm0.74499564
91MP0005332_abnormal_amino_acid0.74446311
92MP0009745_abnormal_behavioral_response0.72704633
93MP0002398_abnormal_bone_marrow0.70719031
94MP0003075_altered_response_to0.70704387
95MP0002429_abnormal_blood_cell0.70186238
96MP0000716_abnormal_immune_system0.70027163
97MP0008058_abnormal_DNA_repair0.69662608
98MP0000613_abnormal_salivary_gland0.68287557
99MP0005376_homeostasis/metabolism_phenot0.66951358
100MP0002090_abnormal_vision0.66919464

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)7.08838889
2Testicular atrophy (HP:0000029)5.51246370
3Microvesicular hepatic steatosis (HP:0001414)4.23300996
4Acute necrotizing encephalopathy (HP:0006965)3.91497121
5Bile duct proliferation (HP:0001408)3.76114868
6Abnormal biliary tract physiology (HP:0012439)3.76114868
7Increased hepatocellular lipid droplets (HP:0006565)3.74276053
8Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.68702450
9Abnormality of B cell number (HP:0010975)3.65933122
10Mitochondrial inheritance (HP:0001427)3.59759241
11Increased CSF lactate (HP:0002490)3.48008308
12Methylmalonic acidemia (HP:0002912)3.47551773
13Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.46561313
14Lipid accumulation in hepatocytes (HP:0006561)3.44495900
15Progressive macrocephaly (HP:0004481)3.40637334
16Dyschromatopsia (HP:0007641)3.37621331
17B lymphocytopenia (HP:0010976)3.37106112
18Abnormal mitochondria in muscle tissue (HP:0008316)3.34483279
19Severe visual impairment (HP:0001141)3.32264236
20Acute encephalopathy (HP:0006846)3.20890913
21Pancreatic cysts (HP:0001737)3.12289146
22Methylmalonic aciduria (HP:0012120)3.02260860
23Renovascular hypertension (HP:0100817)3.02107695
24Congenital, generalized hypertrichosis (HP:0004540)3.01777228
25Dicarboxylic aciduria (HP:0003215)2.94122054
26Abnormality of dicarboxylic acid metabolism (HP:0010995)2.94122054
27Abnormal drinking behavior (HP:0030082)2.90543932
28Polydipsia (HP:0001959)2.90543932
29Chronic diarrhea (HP:0002028)2.90150165
30Exertional dyspnea (HP:0002875)2.88541320
31Increased serum lactate (HP:0002151)2.70856936
32Renal Fanconi syndrome (HP:0001994)2.70426568
33Ragged-red muscle fibers (HP:0003200)2.62797816
34Molar tooth sign on MRI (HP:0002419)2.59880411
35Abnormality of midbrain morphology (HP:0002418)2.59880411
36Absent rod-and cone-mediated responses on ERG (HP:0007688)2.59119222
37Increased intramyocellular lipid droplets (HP:0012240)2.56199653
38Abnormality of the renal cortex (HP:0011035)2.54246573
39Respiratory difficulties (HP:0002880)2.53914596
40Tubulointerstitial nephritis (HP:0001970)2.52373401
41Optic disc pallor (HP:0000543)2.50922332
42Parakeratosis (HP:0001036)2.48637017
43Alveolar cell carcinoma (HP:0006519)2.41986806
44Attenuation of retinal blood vessels (HP:0007843)2.41122489
45Hypoproteinemia (HP:0003075)2.39832372
46Sensory axonal neuropathy (HP:0003390)2.39597515
47Hepatocellular necrosis (HP:0001404)2.38163855
48Abolished electroretinogram (ERG) (HP:0000550)2.38089150
49Macrocytic anemia (HP:0001972)2.37025440
50Cerebral edema (HP:0002181)2.30891574
51Paralysis (HP:0003470)2.28165702
52Elfin facies (HP:0004428)2.25580161
53Tubulointerstitial abnormality (HP:0001969)2.24640110
54Nephronophthisis (HP:0000090)2.20357530
55Decreased electroretinogram (ERG) amplitude (HP:0000654)2.18713012
56Congenital stationary night blindness (HP:0007642)2.18404751
57Abnormality of the vitamin B12 metabolism (HP:0004341)2.17047951
58Hepatic necrosis (HP:0002605)2.14568660
59Lactic acidosis (HP:0003128)2.10586743
60Increased muscle lipid content (HP:0009058)2.10294564
61Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.07587298
62Renal cortical cysts (HP:0000803)2.06588020
63Polyuria (HP:0000103)2.06283401
64Abnormality of eosinophils (HP:0001879)2.02964768
65Chronic hepatic failure (HP:0100626)2.01869702
66Severe combined immunodeficiency (HP:0004430)2.01103791
67Abnormality of the diencephalon (HP:0010662)1.99366287
68Increased IgM level (HP:0003496)1.99355510
69Abnormality of vitamin B metabolism (HP:0004340)1.98913498
70Neoplasm of the tracheobronchial system (HP:0100552)1.97837641
71Enlarged epiphyses (HP:0010580)1.97798509
72Myotonia (HP:0002486)1.97725640
73Abnormality of the prostate (HP:0008775)1.94327030
74Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92963973
75Tubular atrophy (HP:0000092)1.91745428
76Median cleft lip (HP:0000161)1.91443614
77Exercise intolerance (HP:0003546)1.90420056
78Abnormality of vitamin metabolism (HP:0100508)1.88071495
79Megalencephaly (HP:0001355)1.87485278
80Conical tooth (HP:0000698)1.87080357
81Respiratory failure (HP:0002878)1.86070929
82Overriding aorta (HP:0002623)1.82836451
83Thyroiditis (HP:0100646)1.82374959
84Pancreatic fibrosis (HP:0100732)1.81824298
85Malnutrition (HP:0004395)1.81603448
86Tubulointerstitial fibrosis (HP:0005576)1.81410736
87Increased purine levels (HP:0004368)1.80681738
88Hyperuricemia (HP:0002149)1.80681738
89Abnormal rod and cone electroretinograms (HP:0008323)1.80174195
90Progressive muscle weakness (HP:0003323)1.80133514
91Lethargy (HP:0001254)1.78707185
92Abnormality of renal resorption (HP:0011038)1.77131954
93Constricted visual fields (HP:0001133)1.75535806
94Eosinophilia (HP:0001880)1.73206910
95Megaloblastic anemia (HP:0001889)1.72578133
96Hyperacusis (HP:0010780)1.69924736
97Long nose (HP:0003189)1.69822869
98IgG deficiency (HP:0004315)1.66935313
99Abnormal urine output (HP:0012590)1.66416524
100Cleft eyelid (HP:0000625)1.66253875

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LIMK14.81922317
2EIF2AK34.21124724
3TIE14.02338924
4MAP4K13.71925082
5CDK83.34770026
6SCYL23.06980602
7EIF2AK12.73709622
8TXK2.61451880
9TLK12.44476483
10SRPK12.38943398
11CDC42BPA2.27826052
12KIT2.24101935
13CLK12.03278219
14ADRBK21.95882158
15ZAP701.92316242
16CAMKK21.79474281
17TRIM281.73001850
18KDR1.71650475
19NUAK11.69208842
20GRK11.67864168
21BRSK11.67047455
22TEC1.60980893
23MST41.49207259
24NME21.45192153
25ZAK1.36804430
26BMPR21.30945160
27SYK1.24117674
28BMPR1B1.17720381
29BLK1.14185480
30WNK41.12735067
31FRK1.09811160
32TGFBR11.09771703
33ACVR1B1.03229623
34LYN0.96774330
35EIF2AK20.95788194
36RPS6KA50.95587573
37ITK0.95494964
38JAK30.93021257
39DYRK20.90119235
40VRK20.89559764
41RIPK40.88742217
42BCKDK0.85058436
43FES0.82541654
44MAP3K110.81607209
45MYLK0.81480603
46IRAK40.80675429
47BTK0.78478415
48INSRR0.78190532
49TYK20.78003393
50GRK60.77385745
51CSNK1G30.76366139
52CSNK1A1L0.75871220
53ILK0.75658509
54PIK3CG0.73085380
55CSNK1G10.70409964
56MAPK110.65851279
57TNK20.63764685
58IKBKB0.60836517
59STK390.60242308
60RPS6KA40.56852673
61PAK10.56283953
62MELK0.56239554
63CSNK1G20.55960002
64BUB10.55567050
65JAK10.55190361
66CSNK2A20.53152134
67MAP4K20.51629543
68CAMKK10.49239010
69OXSR10.48953302
70TSSK60.48193445
71MAPKAPK20.47494603
72HCK0.46319447
73NEK10.46002291
74BRSK20.45467297
75PAK30.43031813
76PAK20.41887670
77STK160.41413276
78ATR0.40863063
79PRKCE0.40394126
80PNCK0.39673827
81CDC70.37676807
82MATK0.37096169
83CDK40.36879014
84CSNK2A10.35656394
85AKT30.33688196
86ROCK20.33621894
87PHKG20.32351227
88PHKG10.32351227
89OBSCN0.31375633
90CHEK10.31125912
91ROCK10.30478418
92PRKG10.30074889
93VRK10.29917203
94ERBB20.28962306
95RPS6KB20.27429850
96MAP2K60.27041563
97NLK0.26576622
98CSK0.26472434
99PBK0.26313711
100PRKAA20.25807879

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.99134679
2Allograft rejection_Homo sapiens_hsa053303.64951184
3Ribosome_Homo sapiens_hsa030103.59641536
4Autoimmune thyroid disease_Homo sapiens_hsa053203.50934740
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.43982641
6Proteasome_Homo sapiens_hsa030503.36071196
7Oxidative phosphorylation_Homo sapiens_hsa001903.07696113
8Graft-versus-host disease_Homo sapiens_hsa053323.05064677
9Type I diabetes mellitus_Homo sapiens_hsa049402.86190164
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.83503100
11Parkinsons disease_Homo sapiens_hsa050122.76960202
12Protein export_Homo sapiens_hsa030602.19659921
13Sulfur metabolism_Homo sapiens_hsa009202.14336731
14Antigen processing and presentation_Homo sapiens_hsa046121.91184777
15Sulfur relay system_Homo sapiens_hsa041221.76405780
16RNA degradation_Homo sapiens_hsa030181.70741974
17Huntingtons disease_Homo sapiens_hsa050161.70498992
18RNA polymerase_Homo sapiens_hsa030201.70072469
19Viral myocarditis_Homo sapiens_hsa054161.67046077
20Alzheimers disease_Homo sapiens_hsa050101.54488309
21Rheumatoid arthritis_Homo sapiens_hsa053231.45110471
22Spliceosome_Homo sapiens_hsa030401.39410429
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37256912
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36142365
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33402806
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.29323332
27Leishmaniasis_Homo sapiens_hsa051401.28148318
28Regulation of autophagy_Homo sapiens_hsa041401.27058296
29Staphylococcus aureus infection_Homo sapiens_hsa051501.26403023
30Primary immunodeficiency_Homo sapiens_hsa053401.22219772
31Linoleic acid metabolism_Homo sapiens_hsa005911.21897016
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17548854
33Systemic lupus erythematosus_Homo sapiens_hsa053221.16637009
34Homologous recombination_Homo sapiens_hsa034401.14775733
35Non-homologous end-joining_Homo sapiens_hsa034501.13447074
36Fanconi anemia pathway_Homo sapiens_hsa034601.03043310
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.00803593
38Arachidonic acid metabolism_Homo sapiens_hsa005900.99840328
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99834482
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97487663
41DNA replication_Homo sapiens_hsa030300.96518609
42Pyrimidine metabolism_Homo sapiens_hsa002400.95732779
43Cardiac muscle contraction_Homo sapiens_hsa042600.95716717
44Hematopoietic cell lineage_Homo sapiens_hsa046400.95280471
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93316096
46RNA transport_Homo sapiens_hsa030130.93017769
47Ether lipid metabolism_Homo sapiens_hsa005650.90937345
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90239271
49Nitrogen metabolism_Homo sapiens_hsa009100.89356950
50Legionellosis_Homo sapiens_hsa051340.86939671
51Fat digestion and absorption_Homo sapiens_hsa049750.84402331
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79333253
53Nucleotide excision repair_Homo sapiens_hsa034200.76079906
54Glutathione metabolism_Homo sapiens_hsa004800.74652724
55Purine metabolism_Homo sapiens_hsa002300.67782472
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67729608
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.66759043
58Herpes simplex infection_Homo sapiens_hsa051680.64371950
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63896959
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.63453102
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.62444060
62Tryptophan metabolism_Homo sapiens_hsa003800.61966675
63Propanoate metabolism_Homo sapiens_hsa006400.59335513
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55843333
65Mismatch repair_Homo sapiens_hsa034300.51274331
66Olfactory transduction_Homo sapiens_hsa047400.51214613
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50699012
68Toxoplasmosis_Homo sapiens_hsa051450.49058422
69Metabolic pathways_Homo sapiens_hsa011000.46761511
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46236357
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44938544
72Pancreatic secretion_Homo sapiens_hsa049720.44270881
73Chemical carcinogenesis_Homo sapiens_hsa052040.44113177
74Collecting duct acid secretion_Homo sapiens_hsa049660.43894229
75Base excision repair_Homo sapiens_hsa034100.43522359
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42519213
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40584861
78Caffeine metabolism_Homo sapiens_hsa002320.39874274
79Basal transcription factors_Homo sapiens_hsa030220.39527735
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38703696
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.37102827
82Measles_Homo sapiens_hsa051620.36693782
83Epstein-Barr virus infection_Homo sapiens_hsa051690.35807341
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33824795
85Tuberculosis_Homo sapiens_hsa051520.33670751
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32131068
87Starch and sucrose metabolism_Homo sapiens_hsa005000.31041641
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.30940515
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30594913
90Phagosome_Homo sapiens_hsa041450.29439163
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27818286
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27718387
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.27090188
94Phototransduction_Homo sapiens_hsa047440.25870909
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24095242
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23973017
97Peroxisome_Homo sapiens_hsa041460.23592502
98Vitamin digestion and absorption_Homo sapiens_hsa049770.22952373
99Influenza A_Homo sapiens_hsa051640.22826674
100Mineral absorption_Homo sapiens_hsa049780.19852513

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