ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	hematopoietic stem cell proliferation (GO:0071425)	7.04419326
2	negative regulation of circadian rhythm (GO:0042754)	5.60361291
3	protein K11-linked deubiquitination (GO:0035871)	5.00768086
4	lactate metabolic process (GO:0006089)	4.56522668
5	synapsis (GO:0007129)	4.53773744
6	cilium or flagellum-dependent cell motility (GO:0001539)	4.24601616
7	autophagic vacuole fusion (GO:0000046)	3.86656457
8	serotonin receptor signaling pathway (GO:0007210)	3.86221736
9	replication fork processing (GO:0031297)	3.85049132
10	carnitine metabolic process (GO:0009437)	3.76998680
11	DNA integration (GO:0015074)	3.67343193
12	regulation of neurotransmitter uptake (GO:0051580)	3.65917423
13	piRNA metabolic process (GO:0034587)	3.64810341
14	mast cell activation involved in immune response (GO:0002279)	3.64432761
15	mast cell degranulation (GO:0043303)	3.64432761
16	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.61887516
17	intra-S DNA damage checkpoint (GO:0031573)	3.54358209
18	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	3.53042945
19	organelle membrane fusion (GO:0090174)	3.50403911
20	retinal cone cell development (GO:0046549)	3.44629734
21	organic cation transport (GO:0015695)	3.43816690
22	epithelial cilium movement (GO:0003351)	3.39401606
23	male meiosis (GO:0007140)	3.38444227
24	negative regulation of epidermal cell differentiation (GO:0045605)	3.34766998
25	adenosine metabolic process (GO:0046085)	3.28757769
26	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.26448487
27	regulation of transmission of nerve impulse (GO:0051969)	3.24249880
28	DNA methylation involved in gamete generation (GO:0043046)	3.23059184
29	DNA replication-dependent nucleosome assembly (GO:0006335)	3.22705523
30	DNA replication-dependent nucleosome organization (GO:0034723)	3.22705523
31	positive regulation of glomerulus development (GO:0090193)	3.19690540
32	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	3.18455569
33	androgen biosynthetic process (GO:0006702)	3.18060556
34	acrosome reaction (GO:0007340)	3.17082897
35	lysosome localization (GO:0032418)	3.10928273
36	DNA strand elongation involved in DNA replication (GO:0006271)	3.10095686
37	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.09223023
38	DNA ligation (GO:0006266)	3.09096088
39	meiotic chromosome segregation (GO:0045132)	3.09022753
40	regulation of appetite (GO:0032098)	3.04995887
41	mitochondrial DNA replication (GO:0006264)	3.04968605
42	resolution of meiotic recombination intermediates (GO:0000712)	3.03592499
43	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.01776662
44	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.99789869
45	platelet dense granule organization (GO:0060155)	2.97462215
46	centriole replication (GO:0007099)	2.93666173
47	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.92971783
48	cysteine metabolic process (GO:0006534)	2.92291476
49	telomere maintenance via semi-conservative replication (GO:0032201)	2.88336314
50	DNA strand elongation (GO:0022616)	2.86647994
51	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	2.84276600
52	chromosome organization involved in meiosis (GO:0070192)	2.84261656
53	cilium morphogenesis (GO:0060271)	2.82365929
54	DNA double-strand break processing (GO:0000729)	2.82090515
55	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.81865959
56	negative regulation of keratinocyte proliferation (GO:0010839)	2.81827294
57	regulation of metanephros development (GO:0072215)	2.80989382
58	ubiquinone biosynthetic process (GO:0006744)	2.80594495
59	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.80470938
60	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.79650645
61	kinetochore organization (GO:0051383)	2.79066467
62	amino-acid betaine metabolic process (GO:0006577)	2.78480460
63	regulation of amino acid transport (GO:0051955)	2.78267004
64	DNA deamination (GO:0045006)	2.77038514
65	regulation of B cell receptor signaling pathway (GO:0050855)	2.76024989
66	spermatid development (GO:0007286)	2.75995178
67	cilium movement (GO:0003341)	2.75478359
68	negative regulation of translational initiation (GO:0045947)	2.73373290
69	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.71722389
70	angiogenesis involved in wound healing (GO:0060055)	2.71230640
71	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.70742376
72	cellular ketone body metabolic process (GO:0046950)	2.69766092
73	retinal ganglion cell axon guidance (GO:0031290)	2.69623139
74	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.66445830
75	interferon-gamma production (GO:0032609)	2.65127531
76	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	2.64110359
77	neural tube formation (GO:0001841)	2.62806872
78	negative regulation of telomere maintenance (GO:0032205)	2.62250887
79	negative regulation of complement activation (GO:0045916)	2.61626867
80	positive regulation of prostaglandin secretion (GO:0032308)	2.59940831
81	attachment of spindle microtubules to kinetochore (GO:0008608)	2.57219867
82	ubiquinone metabolic process (GO:0006743)	2.56645964
83	negative regulation of neurological system process (GO:0031645)	2.52869686
84	regulation of glomerulus development (GO:0090192)	2.52645376
85	cornea development in camera-type eye (GO:0061303)	2.50619427
86	negative regulation of JNK cascade (GO:0046329)	2.50112659
87	cell fate commitment involved in formation of primary germ layer (GO:0060795)	2.49786008
88	kinetochore assembly (GO:0051382)	2.49126800
89	regulation of oxidative stress-induced neuron death (GO:1903203)	2.49100140
90	maturation of 5.8S rRNA (GO:0000460)	2.48237756
91	sulfation (GO:0051923)	2.47317255
92	meiotic cell cycle (GO:0051321)	2.46810518
93	DNA-dependent DNA replication (GO:0006261)	2.44912016
94	protein K63-linked deubiquitination (GO:0070536)	2.44862092
95	tryptophan metabolic process (GO:0006568)	2.44274439
96	multicellular organism reproduction (GO:0032504)	2.44067851
97	aspartate family amino acid catabolic process (GO:0009068)	2.42873223
98	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.42654611
99	pseudouridine synthesis (GO:0001522)	2.42173915
100	dopamine transport (GO:0015872)	2.41372572

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	6.21437108
2	E2F7_22180533_ChIP-Seq_HELA_Human	4.01268281
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.74777992
4	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	3.60900729
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.03843877
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.98934294
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.89304219
8	FUS_26573619_Chip-Seq_HEK293_Human	2.70872678
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.70746809
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.61264523
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.60201211
12	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.43616796
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.43099020
14	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.41510842
15	EWS_26573619_Chip-Seq_HEK293_Human	2.35089576
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.29289134
17	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.24775342
18	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.20386899
19	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.13244954
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.12139643
21	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.03812773
22	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.01105849
23	ZNF274_21170338_ChIP-Seq_K562_Hela	1.92006265
24	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.90320958
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.85968152
26	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.84637174
27	VDR_22108803_ChIP-Seq_LS180_Human	1.83197623
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.83023145
29	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.79613603
30	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.76962731
31	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.73852518
32	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.71867558
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.71423102
34	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.69951518
35	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.69125349
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.69075381
37	P300_19829295_ChIP-Seq_ESCs_Human	1.69037356
38	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.64418964
39	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.55160469
40	IRF1_19129219_ChIP-ChIP_H3396_Human	1.54927667
41	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.50345544
42	VDR_23849224_ChIP-Seq_CD4+_Human	1.48448558
43	AR_25329375_ChIP-Seq_VCAP_Human	1.47303089
44	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.43471270
45	CBP_20019798_ChIP-Seq_JUKART_Human	1.40424430
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40424430
47	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.38648032
48	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.37682956
49	ELK1_19687146_ChIP-ChIP_HELA_Human	1.33413469
50	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.30176603
51	FOXP3_21729870_ChIP-Seq_TREG_Human	1.29149624
52	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.26848370
53	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.26343987
54	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.25637163
55	BCAT_22108803_ChIP-Seq_LS180_Human	1.25532394
56	TP53_22573176_ChIP-Seq_HFKS_Human	1.25306454
57	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.24791662
58	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.23874783
59	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.20015449
60	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.18042814
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17786168
62	EZH2_22144423_ChIP-Seq_EOC_Human	1.17181580
63	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.16602725
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12340642
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12340642
66	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.12126554
67	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.11451278
68	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.10638431
69	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.10287908
70	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10253335
71	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.09563479
72	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.08732067
73	DCP1A_22483619_ChIP-Seq_HELA_Human	1.08535629
74	ERG_20517297_ChIP-Seq_VCAP_Human	1.08328058
75	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.06595004
76	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.06588055
77	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.06246403
78	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03936126
79	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03928161
80	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03928161
81	SMAD4_21799915_ChIP-Seq_A2780_Human	1.02042970
82	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.99154799
83	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.98143881
84	STAT3_23295773_ChIP-Seq_U87_Human	0.97508487
85	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.97083041
86	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.96883259
87	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.94567579
88	AR_20517297_ChIP-Seq_VCAP_Human	0.94156339
89	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.93852562
90	KDM5A_27292631_Chip-Seq_BREAST_Human	0.92784914
91	TCF4_22108803_ChIP-Seq_LS180_Human	0.92332967
92	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.90257901
93	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.87655821
94	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.87165546
95	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.86948983
96	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.86157019
97	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.85856844
98	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.85642283
99	NANOG_20526341_ChIP-Seq_ESCs_Human	0.85536191
100	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.85260404

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002138_abnormal_hepatobiliary_system	3.88726857
2	MP0005646_abnormal_pituitary_gland	3.31366247
3	MP0008995_early_reproductive_senescence	3.01828711
4	MP0010094_abnormal_chromosome_stability	2.99790671
5	MP0000613_abnormal_salivary_gland	2.89198830
6	MP0005187_abnormal_penis_morphology	2.82166506
7	MP0008057_abnormal_DNA_replication	2.82005136
8	MP0003880_abnormal_central_pattern	2.76066138
9	MP0003806_abnormal_nucleotide_metabolis	2.71698867
10	MP0008875_abnormal_xenobiotic_pharmacok	2.68143479
11	MP0001919_abnormal_reproductive_system	2.45185085
12	MP0008058_abnormal_DNA_repair	2.44328132
13	MP0005389_reproductive_system_phenotype	2.40115919
14	MP0003943_abnormal_hepatobiliary_system	2.35991621
15	MP0003718_maternal_effect	2.35479995
16	MP0006054_spinal_hemorrhage	2.33960548
17	MP0005410_abnormal_fertilization	2.28973091
18	MP0001984_abnormal_olfaction	2.10972744
19	MP0005645_abnormal_hypothalamus_physiol	2.05509029
20	MP0004808_abnormal_hematopoietic_stem	2.01719791
21	MP0003786_premature_aging	1.89294449
22	MP0001835_abnormal_antigen_presentation	1.85234117
23	MP0001764_abnormal_homeostasis	1.84427368
24	MP0005084_abnormal_gallbladder_morpholo	1.75904178
25	MP0008961_abnormal_basal_metabolism	1.70808675
26	MP0002160_abnormal_reproductive_system	1.66326148
27	MP0009278_abnormal_bone_marrow	1.57410967
28	MP0001501_abnormal_sleep_pattern	1.54764553
29	MP0002876_abnormal_thyroid_physiology	1.50676036
30	MP0000685_abnormal_immune_system	1.47696189
31	MP0005253_abnormal_eye_physiology	1.47423730
32	MP0003195_calcinosis	1.42065566
33	MP0005464_abnormal_platelet_physiology	1.40532479
34	MP0002638_abnormal_pupillary_reflex	1.40003370
35	MP0006276_abnormal_autonomic_nervous	1.39166762
36	MP0006072_abnormal_retinal_apoptosis	1.37819579
37	MP0009697_abnormal_copulation	1.35707801
38	MP0008872_abnormal_physiological_respon	1.34447834
39	MP0001929_abnormal_gametogenesis	1.33407904
40	MP0003693_abnormal_embryo_hatching	1.29648820
41	MP0000653_abnormal_sex_gland	1.29375809
42	MP0002234_abnormal_pharynx_morphology	1.29023071
43	MP0003698_abnormal_male_reproductive	1.28970970
44	MP0001849_ear_inflammation	1.27678236
45	MP0005647_abnormal_sex_gland	1.25339604
46	MP0005397_hematopoietic_system_phenotyp	1.23884366
47	MP0001545_abnormal_hematopoietic_system	1.23884366
48	MP0005551_abnormal_eye_electrophysiolog	1.19522061
49	MP0000465_gastrointestinal_hemorrhage	1.19342068
50	MP0005220_abnormal_exocrine_pancreas	1.18989801
51	MP0003077_abnormal_cell_cycle	1.17520845
52	MP0004043_abnormal_pH_regulation	1.16330146
53	MP0001145_abnormal_male_reproductive	1.14808666
54	MP0010386_abnormal_urinary_bladder	1.12876893
55	MP0002210_abnormal_sex_determination	1.10723293
56	MP0005367_renal/urinary_system_phenotyp	1.10710022
57	MP0000516_abnormal_urinary_system	1.10710022
58	MP0002736_abnormal_nociception_after	1.08075168
59	MP0005595_abnormal_vascular_smooth	1.04002676
60	MP0005395_other_phenotype	1.03568666
61	MP0008789_abnormal_olfactory_epithelium	1.02891968
62	MP0008932_abnormal_embryonic_tissue	1.02559097
63	MP0005394_taste/olfaction_phenotype	1.01585469
64	MP0005499_abnormal_olfactory_system	1.01585469
65	MP0010307_abnormal_tumor_latency	1.01370638
66	MP0000372_irregular_coat_pigmentation	0.99000616
67	MP0005423_abnormal_somatic_nervous	0.98307388
68	MP0006036_abnormal_mitochondrial_physio	0.97561871
69	MP0002139_abnormal_hepatobiliary_system	0.92854888
70	MP0003315_abnormal_perineum_morphology	0.92340963
71	MP0008007_abnormal_cellular_replicative	0.91660504
72	MP0009780_abnormal_chondrocyte_physiolo	0.90655243
73	MP0002090_abnormal_vision	0.89451423
74	MP0001119_abnormal_female_reproductive	0.88019201
75	MP0000538_abnormal_urinary_bladder	0.87728631
76	MP0002102_abnormal_ear_morphology	0.86653315
77	MP0004147_increased_porphyrin_level	0.86626154
78	MP0003724_increased_susceptibility_to	0.85786620
79	MP0002282_abnormal_trachea_morphology	0.83461472
80	MP0001800_abnormal_humoral_immune	0.82676924
81	MP0006035_abnormal_mitochondrial_morpho	0.79891277
82	MP0002006_tumorigenesis	0.79559670
83	MP0003111_abnormal_nucleus_morphology	0.77337402
84	MP0001529_abnormal_vocalization	0.77226219
85	MP0000689_abnormal_spleen_morphology	0.76284004
86	MP0003136_yellow_coat_color	0.75991070
87	MP0003868_abnormal_feces_composition	0.75169520
88	MP0000230_abnormal_systemic_arterial	0.74825070
89	MP0002019_abnormal_tumor_incidence	0.74125538
90	MP0006292_abnormal_olfactory_placode	0.73722828
91	MP0001664_abnormal_digestion	0.73272719
92	MP0002398_abnormal_bone_marrow	0.73271188
93	MP0000631_abnormal_neuroendocrine_gland	0.71916150
94	MP0000647_abnormal_sebaceous_gland	0.71072221
95	MP0002452_abnormal_antigen_presenting	0.70096182
96	MP0001324_abnormal_eye_pigmentation	0.69765820
97	MP0001986_abnormal_taste_sensitivity	0.69348923
98	MP0009764_decreased_sensitivity_to	0.68492080
99	MP0004883_abnormal_blood_vessel	0.65801882
100	MP0001968_abnormal_touch/_nociception	0.65261895

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of lateral ventricle (HP:0030047)	4.41917840
2	True hermaphroditism (HP:0010459)	3.89530478
3	Pancreatic cysts (HP:0001737)	3.70798193
4	Hypoplasia of the uterus (HP:0000013)	3.65372698
5	Diastasis recti (HP:0001540)	3.45991485
6	Abolished electroretinogram (ERG) (HP:0000550)	3.42729520
7	Poikiloderma (HP:0001029)	3.34785220
8	3-Methylglutaconic aciduria (HP:0003535)	3.31344826
9	Pancreatic fibrosis (HP:0100732)	3.24334283
10	Panhypogammaglobulinemia (HP:0003139)	3.20058166
11	Male pseudohermaphroditism (HP:0000037)	3.08420591
12	Decreased central vision (HP:0007663)	2.96231308
13	Dyschromatopsia (HP:0007641)	2.88479545
14	Aplasia/hypoplasia of the uterus (HP:0008684)	2.87605469
15	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.85274307
16	Meckel diverticulum (HP:0002245)	2.82581927
17	Abnormality of the ileum (HP:0001549)	2.81546121
18	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.79908363
19	Fibular aplasia (HP:0002990)	2.77191607
20	Abnormality of DNA repair (HP:0003254)	2.73036116
21	Reduced antithrombin III activity (HP:0001976)	2.63307477
22	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.60421746
23	Absent/shortened dynein arms (HP:0200106)	2.60421746
24	B lymphocytopenia (HP:0010976)	2.59602758
25	Keratoconus (HP:0000563)	2.59010086
26	Increased corneal curvature (HP:0100692)	2.59010086
27	Attenuation of retinal blood vessels (HP:0007843)	2.58235790
28	Hyperglycinemia (HP:0002154)	2.56447569
29	Abnormality of chromosome stability (HP:0003220)	2.52641702
30	Cutaneous melanoma (HP:0012056)	2.49053626
31	Abnormal ciliary motility (HP:0012262)	2.47146141
32	Abnormal respiratory epithelium morphology (HP:0012253)	2.45072413
33	Abnormal respiratory motile cilium morphology (HP:0005938)	2.45072413
34	Cystic liver disease (HP:0006706)	2.40903847
35	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	2.40070151
36	Abnormality of B cell number (HP:0010975)	2.39958243
37	Clubbing of toes (HP:0100760)	2.39388808
38	Gonadotropin excess (HP:0000837)	2.39258137
39	Abnormality of glycine metabolism (HP:0010895)	2.38948065
40	Abnormality of serine family amino acid metabolism (HP:0010894)	2.38948065
41	Chronic sinusitis (HP:0011109)	2.37208931
42	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.34764432
43	Agammaglobulinemia (HP:0004432)	2.34659629
44	Asplenia (HP:0001746)	2.30698195
45	Abnormality of serum amino acid levels (HP:0003112)	2.29886423
46	Duodenal stenosis (HP:0100867)	2.29511388
47	Small intestinal stenosis (HP:0012848)	2.29511388
48	Abnormality of the preputium (HP:0100587)	2.29321640
49	Broad foot (HP:0001769)	2.27344737
50	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.26027643
51	Tubulointerstitial abnormality (HP:0001969)	2.21680967
52	Supernumerary spleens (HP:0009799)	2.19122035
53	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.15664149
54	Hyperglycinuria (HP:0003108)	2.12695716
55	Nephronophthisis (HP:0000090)	2.12389188
56	Medial flaring of the eyebrow (HP:0010747)	2.12289843
57	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.11225265
58	Deformed tarsal bones (HP:0008119)	2.10710034
59	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.10159695
60	Abnormality of alanine metabolism (HP:0010916)	2.10159695
61	Hyperalaninemia (HP:0003348)	2.10159695
62	Short 4th metacarpal (HP:0010044)	2.08651642
63	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.08651642
64	Tubulointerstitial fibrosis (HP:0005576)	2.06798966
65	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	2.06722913
66	Abnormality of the renal medulla (HP:0100957)	1.99816004
67	Tubulointerstitial nephritis (HP:0001970)	1.93893705
68	Central scotoma (HP:0000603)	1.93676741
69	Abnormal respiratory motile cilium physiology (HP:0012261)	1.93276578
70	Molar tooth sign on MRI (HP:0002419)	1.93160181
71	Abnormality of midbrain morphology (HP:0002418)	1.93160181
72	Abnormality of the renal cortex (HP:0011035)	1.91954496
73	Absent speech (HP:0001344)	1.91758668
74	Occipital encephalocele (HP:0002085)	1.90299622
75	Depressed nasal tip (HP:0000437)	1.89980678
76	Ketosis (HP:0001946)	1.89750675
77	Microvesicular hepatic steatosis (HP:0001414)	1.89351590
78	Erythroderma (HP:0001019)	1.87423756
79	Abnormality of the duodenum (HP:0002246)	1.87160871
80	Infertility (HP:0000789)	1.86555050
81	Tinnitus (HP:0000360)	1.86356090
82	Oligohydramnios (HP:0001562)	1.85829345
83	Optic nerve hypoplasia (HP:0000609)	1.84959089
84	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.84702267
85	Facial diplegia (HP:0001349)	1.83471149
86	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.82864811
87	Congenital primary aphakia (HP:0007707)	1.81849191
88	Abnormality of male internal genitalia (HP:0000022)	1.81040111
89	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.79773219
90	Hypothermia (HP:0002045)	1.79009990
91	Acute lymphatic leukemia (HP:0006721)	1.78766363
92	Thyroiditis (HP:0100646)	1.78318497
93	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.77760818
94	Abnormal protein N-linked glycosylation (HP:0012347)	1.77760818
95	Abnormal protein glycosylation (HP:0012346)	1.77760818
96	Abnormal glycosylation (HP:0012345)	1.77760818
97	Hepatocellular necrosis (HP:0001404)	1.77313976
98	Abnormality of the prostate (HP:0008775)	1.76502311
99	Congenital sensorineural hearing impairment (HP:0008527)	1.76421485
100	Dicarboxylic aciduria (HP:0003215)	1.75923806

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	5.63409146
2	NUAK1	4.22871231
3	BMPR1B	3.92785571
4	FRK	3.57611039
5	PINK1	3.23971332
6	ZAK	3.22658136
7	BCKDK	2.67159730
8	TLK1	2.59780750
9	VRK2	2.10886923
10	WNK3	2.06903324
11	TGFBR1	2.00914472
12	TNIK	2.00396416
13	KIT	1.86312364
14	ICK	1.81875760
15	TAOK3	1.71173118
16	STK38L	1.68979942
17	ACVR1B	1.61404622
18	ERBB3	1.60202053
19	MAP4K2	1.53987421
20	CDK8	1.51541309
21	ZAP70	1.51540453
22	VRK1	1.50633692
23	MAPKAPK3	1.47078282
24	EIF2AK3	1.45026410
25	TRIM28	1.44783140
26	WEE1	1.44269347
27	TXK	1.41551942
28	MAPK13	1.34692224
29	SYK	1.34408175
30	MARK3	1.21949589
31	TIE1	1.16121823
32	BUB1	1.08471468
33	DMPK	1.08412776
34	GRK1	1.07233042
35	PLK4	1.05702400
36	CSNK1G3	1.03142997
37	PLK2	0.99584994
38	KDR	0.97210221
39	CCNB1	0.96806141
40	FLT3	0.96280869
41	MST4	0.86826372
42	CDK7	0.84454525
43	CSF1R	0.84423704
44	PKN1	0.83981953
45	PRKCQ	0.83609163
46	EPHA4	0.82641850
47	CSNK1G1	0.81267350
48	MKNK2	0.80086429
49	PLK3	0.77318126
50	CSNK1G2	0.76042795
51	RPS6KA5	0.75297873
52	STK16	0.74781940
53	CSNK1A1L	0.73063399
54	CLK1	0.70172765
55	DYRK2	0.68209536
56	RAF1	0.68008916
57	CHEK2	0.66172810
58	PLK1	0.65719443
59	MATK	0.63953007
60	PNCK	0.62751175
61	OXSR1	0.61521559
62	ILK	0.59006425
63	EIF2AK1	0.58706120
64	BLK	0.55692323
65	NEK2	0.55602661
66	MKNK1	0.54283689
67	TEC	0.51882943
68	STK39	0.51775380
69	ADRBK2	0.49910749
70	NLK	0.46619820
71	LYN	0.46417732
72	ATM	0.45264468
73	SRPK1	0.43608763
74	TNK2	0.42999418
75	SCYL2	0.42889818
76	ATR	0.42805956
77	TTK	0.42522038
78	GRK7	0.42206890
79	PRKD3	0.40802482
80	WNK4	0.39423921
81	DAPK1	0.38669787
82	FER	0.37709392
83	CSNK2A1	0.36817012
84	PBK	0.35571368
85	PRKACB	0.34730928
86	MINK1	0.33448377
87	AURKA	0.33342150
88	RPS6KB1	0.31807821
89	RPS6KB2	0.31239460
90	BRSK2	0.30991746
91	SIK3	0.28898900
92	AURKB	0.28750142
93	BTK	0.28312291
94	MAP2K7	0.28311293
95	PTK2B	0.28169834
96	PRKG1	0.25980801
97	MAP3K4	0.25744801
98	CSNK1D	0.24938982
99	MELK	0.24514999
100	NEK1	0.24199414

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.01772929
2	DNA replication_Homo sapiens_hsa03030	2.91778804
3	Base excision repair_Homo sapiens_hsa03410	2.86290309
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.68999603
5	Butanoate metabolism_Homo sapiens_hsa00650	2.44237005
6	Proteasome_Homo sapiens_hsa03050	2.43372775
7	Asthma_Homo sapiens_hsa05310	2.39930430
8	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.30986531
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.30443168
10	Non-homologous end-joining_Homo sapiens_hsa03450	2.27081726
11	Phototransduction_Homo sapiens_hsa04744	2.18644095
12	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.12953722
13	Homologous recombination_Homo sapiens_hsa03440	2.11273921
14	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.07134900
15	Mismatch repair_Homo sapiens_hsa03430	2.04097274
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.02522466
17	Olfactory transduction_Homo sapiens_hsa04740	1.82546232
18	Protein export_Homo sapiens_hsa03060	1.81392803
19	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.72984389
20	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.70916241
21	Propanoate metabolism_Homo sapiens_hsa00640	1.66871754
22	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.63508746
23	Allograft rejection_Homo sapiens_hsa05330	1.60714640
24	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.57301994
25	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.56896107
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.55878638
27	Primary immunodeficiency_Homo sapiens_hsa05340	1.51321240
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.50310905
29	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.43084152
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.40772943
31	RNA degradation_Homo sapiens_hsa03018	1.39346461
32	Graft-versus-host disease_Homo sapiens_hsa05332	1.39267103
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.39019156
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.37827024
35	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.35154273
36	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.31531074
37	RNA transport_Homo sapiens_hsa03013	1.21256856
38	Fatty acid metabolism_Homo sapiens_hsa01212	1.20059996
39	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.19014165
40	Linoleic acid metabolism_Homo sapiens_hsa00591	1.17970142
41	Alcoholism_Homo sapiens_hsa05034	1.17861029
42	Selenocompound metabolism_Homo sapiens_hsa00450	1.17063902
43	Peroxisome_Homo sapiens_hsa04146	1.16998781
44	Parkinsons disease_Homo sapiens_hsa05012	1.13188750
45	Fatty acid elongation_Homo sapiens_hsa00062	1.04098526
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.03513342
47	Type I diabetes mellitus_Homo sapiens_hsa04940	1.03095673
48	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.01301554
49	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.00914505
50	Tryptophan metabolism_Homo sapiens_hsa00380	0.99790617
51	Antigen processing and presentation_Homo sapiens_hsa04612	0.98018739
52	Pyrimidine metabolism_Homo sapiens_hsa00240	0.97003454
53	Purine metabolism_Homo sapiens_hsa00230	0.93191344
54	Glutathione metabolism_Homo sapiens_hsa00480	0.92233577
55	Fatty acid degradation_Homo sapiens_hsa00071	0.90358322
56	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.88670839
57	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.87231348
58	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.83687874
59	p53 signaling pathway_Homo sapiens_hsa04115	0.81072975
60	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.79510731
61	Regulation of autophagy_Homo sapiens_hsa04140	0.79233724
62	Viral myocarditis_Homo sapiens_hsa05416	0.77358398
63	RNA polymerase_Homo sapiens_hsa03020	0.73536801
64	Oocyte meiosis_Homo sapiens_hsa04114	0.71941770
65	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.70773126
66	Salivary secretion_Homo sapiens_hsa04970	0.66381849
67	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.65501468
68	Huntingtons disease_Homo sapiens_hsa05016	0.65315938
69	One carbon pool by folate_Homo sapiens_hsa00670	0.64496360
70	Oxidative phosphorylation_Homo sapiens_hsa00190	0.62965112
71	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.62670513
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.62567096
73	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.61927306
74	Gap junction_Homo sapiens_hsa04540	0.60793357
75	Herpes simplex infection_Homo sapiens_hsa05168	0.58076005
76	Basal transcription factors_Homo sapiens_hsa03022	0.56960814
77	Circadian entrainment_Homo sapiens_hsa04713	0.56813779
78	Taste transduction_Homo sapiens_hsa04742	0.51487989
79	Platelet activation_Homo sapiens_hsa04611	0.51066052
80	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.47937000
81	Phagosome_Homo sapiens_hsa04145	0.47767401
82	Sphingolipid metabolism_Homo sapiens_hsa00600	0.47628127
83	Metabolic pathways_Homo sapiens_hsa01100	0.47066900
84	Circadian rhythm_Homo sapiens_hsa04710	0.44937333
85	Calcium signaling pathway_Homo sapiens_hsa04020	0.44631647
86	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.44245782
87	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.43189744
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40616633
89	Rheumatoid arthritis_Homo sapiens_hsa05323	0.38719524
90	Alzheimers disease_Homo sapiens_hsa05010	0.37543738
91	Chemical carcinogenesis_Homo sapiens_hsa05204	0.37499021
92	Pyruvate metabolism_Homo sapiens_hsa00620	0.35227347
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.34043667
94	Cell cycle_Homo sapiens_hsa04110	0.32786549
95	Lysine degradation_Homo sapiens_hsa00310	0.31376458
96	Pancreatic secretion_Homo sapiens_hsa04972	0.30642831
97	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.29321972
98	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.26148249
99	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.22504877
100	Serotonergic synapse_Homo sapiens_hsa04726	0.21416284

RPL29P23

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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