ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to gravity (GO:0009629)	9.05014914
2	regulation of isotype switching to IgG isotypes (GO:0048302)	6.40804706
3	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	6.38855062
4	skeletal muscle adaptation (GO:0043501)	6.18648967
5	regulation of skeletal muscle contraction (GO:0014819)	5.90675775
6	striated muscle atrophy (GO:0014891)	5.83716721
7	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	5.65919993
8	cellular ketone body metabolic process (GO:0046950)	5.46675896
9	negative regulation of muscle hypertrophy (GO:0014741)	5.26698569
10	muscle filament sliding (GO:0030049)	5.23309654
11	actin-myosin filament sliding (GO:0033275)	5.23309654
12	regulation of immunoglobulin secretion (GO:0051023)	4.96657902
13	positive regulation of DNA recombination (GO:0045911)	4.94395006
14	ketone body metabolic process (GO:1902224)	4.86686978
15	positive regulation of isotype switching (GO:0045830)	4.80729550
16	muscle atrophy (GO:0014889)	4.79153597
17	skeletal muscle tissue regeneration (GO:0043403)	4.76618284
18	response to muscle activity (GO:0014850)	4.73368300
19	regulation of regulatory T cell differentiation (GO:0045589)	4.69740218
20	actin-mediated cell contraction (GO:0070252)	4.35213725
21	regulation of chronic inflammatory response (GO:0002676)	4.34033403
22	positive regulation of histone H3-K4 methylation (GO:0051571)	4.24237088
23	regulation of podosome assembly (GO:0071801)	4.21798000
24	positive regulation of interleukin-17 production (GO:0032740)	3.88726709
25	regulation of relaxation of muscle (GO:1901077)	3.85298091
26	response to activity (GO:0014823)	3.84949306
27	negative regulation of T-helper cell differentiation (GO:0045623)	3.74621858
28	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	3.74621858
29	adult feeding behavior (GO:0008343)	3.64976480
30	negative regulation of skeletal muscle tissue development (GO:0048642)	3.64247056
31	positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)	3.54397505
32	positive regulation of T cell differentiation in thymus (GO:0033089)	3.52916421
33	regulation of centriole replication (GO:0046599)	3.51200845
34	DNA double-strand break processing (GO:0000729)	3.35081921
35	regulation of MHC class II biosynthetic process (GO:0045346)	3.30817477
36	positive regulation of immunoglobulin production (GO:0002639)	3.30725815
37	regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)	3.28974315
38	cellular response to dexamethasone stimulus (GO:0071549)	3.26861431
39	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	3.25716412
40	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	3.25716412
41	regulation of isotype switching (GO:0045191)	3.24553917
42	alpha-beta T cell differentiation involved in immune response (GO:0002293)	3.24128586
43	alpha-beta T cell activation involved in immune response (GO:0002287)	3.24128586
44	T cell differentiation involved in immune response (GO:0002292)	3.24128586
45	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	3.07365259
46	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	3.04982313
47	regulation of interleukin-17 production (GO:0032660)	3.03984358
48	protein polyglutamylation (GO:0018095)	2.99544188
49	response to dexamethasone (GO:0071548)	2.96914081
50	lung secretory cell differentiation (GO:0061140)	2.94957087
51	positive regulation of activated T cell proliferation (GO:0042104)	2.90997234
52	positive regulation of chemokine biosynthetic process (GO:0045080)	2.84838329
53	positive regulation of B cell mediated immunity (GO:0002714)	2.84371955
54	positive regulation of immunoglobulin mediated immune response (GO:0002891)	2.84371955
55	cullin deneddylation (GO:0010388)	2.82867760
56	protein K6-linked ubiquitination (GO:0085020)	2.79942689
57	regulation of immunoglobulin production (GO:0002637)	2.78471521
58	rRNA modification (GO:0000154)	2.76645555
59	heparin metabolic process (GO:0030202)	2.73995176
60	heparin biosynthetic process (GO:0030210)	2.73995176
61	GTP biosynthetic process (GO:0006183)	2.73816139
62	postreplication repair (GO:0006301)	2.73655812
63	seminiferous tubule development (GO:0072520)	2.71318957
64	positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)	2.68599443
65	platelet dense granule organization (GO:0060155)	2.67499393
66	protein neddylation (GO:0045116)	2.64620668
67	CTP metabolic process (GO:0046036)	2.63612942
68	CTP biosynthetic process (GO:0006241)	2.63612942
69	viral mRNA export from host cell nucleus (GO:0046784)	2.61566217
70	negative regulation of alpha-beta T cell differentiation (GO:0046639)	2.60722257
71	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)	2.59760836
72	ribosome biogenesis (GO:0042254)	2.56366457
73	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.55514164
74	water-soluble vitamin biosynthetic process (GO:0042364)	2.54524426
75	regulation of cellular amino acid metabolic process (GO:0006521)	2.54358441
76	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.54150726
77	NADH dehydrogenase complex assembly (GO:0010257)	2.54150726
78	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.54150726
79	peptidyl-histidine modification (GO:0018202)	2.51933366
80	positive regulation of B cell proliferation (GO:0030890)	2.51840387
81	pseudouridine synthesis (GO:0001522)	2.49984769
82	protein deneddylation (GO:0000338)	2.49240403
83	regulation of interleukin-12 biosynthetic process (GO:0045075)	2.48337849
84	proteasome assembly (GO:0043248)	2.48089616
85	transcription from mitochondrial promoter (GO:0006390)	2.47512669
86	protein complex biogenesis (GO:0070271)	2.47345717
87	positive regulation of protein homodimerization activity (GO:0090073)	2.46709868
88	CD4-positive, alpha-beta T cell activation (GO:0035710)	2.46655622
89	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	2.45610989
90	rRNA processing (GO:0006364)	2.45224392
91	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	2.45003965
92	actin filament-based movement (GO:0030048)	2.44743577
93	regulation of histone H3-K4 methylation (GO:0051569)	2.41858733
94	mitochondrial respiratory chain complex assembly (GO:0033108)	2.40458917
95	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.39402895
96	cytidine deamination (GO:0009972)	2.38492565
97	cytidine metabolic process (GO:0046087)	2.38492565
98	cytidine catabolic process (GO:0006216)	2.38492565
99	T-helper cell differentiation (GO:0042093)	2.38389811
100	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	2.38389811

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	5.12048596
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.29629372
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.72062230
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.48507341
5	TAF15_26573619_Chip-Seq_HEK293_Human	3.00559927
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.99926435
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.87602600
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.86683424
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.67174525
10	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.57092218
11	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.26551700
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.24251442
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.23743588
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.19171309
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.18015547
16	FUS_26573619_Chip-Seq_HEK293_Human	2.17331320
17	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.17196502
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.17032392
19	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.16996247
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.13912697
21	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.05140949
22	PADI4_21655091_ChIP-ChIP_MCF-7_Human	2.03069534
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.90848516
24	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.87830368
25	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.84385970
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.83609138
27	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.82434319
28	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.71561744
29	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.60632837
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.60253072
31	EWS_26573619_Chip-Seq_HEK293_Human	1.58742321
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.57206355
33	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.55008354
34	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.53824658
35	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.53289937
36	P300_19829295_ChIP-Seq_ESCs_Human	1.49836697
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.47923689
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.39954557
39	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.39217316
40	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.34349967
41	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.32432203
42	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.31611842
43	GATA1_22025678_ChIP-Seq_K562_Human	1.30442701
44	MYC_18940864_ChIP-ChIP_HL60_Human	1.30124396
45	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.29193311
46	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.29094779
47	TTF2_22483619_ChIP-Seq_HELA_Human	1.28194182
48	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.23490070
49	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.22801554
50	ZNF274_21170338_ChIP-Seq_K562_Hela	1.22750758
51	AR_21572438_ChIP-Seq_LNCaP_Human	1.22175521
52	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.21884090
53	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.21766127
54	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.21689818
55	FOXP3_21729870_ChIP-Seq_TREG_Human	1.21402971
56	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17124384
57	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.15762188
58	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.10473754
59	GBX2_23144817_ChIP-Seq_PC3_Human	1.10407286
60	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.09940663
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.09484578
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.09484578
63	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08370322
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08370322
65	AR_20517297_ChIP-Seq_VCAP_Human	1.05700729
66	P300_18555785_Chip-Seq_ESCs_Mouse	1.05611641
67	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.05605926
68	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05463487
69	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.04260264
70	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.04071630
71	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.04002791
72	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.02609902
73	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.01786326
74	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.00782560
75	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.00420745
76	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.00297864
77	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.99948465
78	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.99496173
79	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98813777
80	TCF4_22108803_ChIP-Seq_LS180_Human	0.98805155
81	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.98478862
82	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.97708627
83	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.97626368
84	NCOR_22424771_ChIP-Seq_293T_Human	0.97568521
85	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.97116184
86	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.95508103
87	DCP1A_22483619_ChIP-Seq_HELA_Human	0.95254756
88	EZH2_22144423_ChIP-Seq_EOC_Human	0.95220266
89	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.95214189
90	P53_22387025_ChIP-Seq_ESCs_Mouse	0.95153461
91	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.93797758
92	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.92364087
93	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.92300988
94	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.91955633
95	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.91897761
96	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.91523004
97	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.91394044
98	ER_23166858_ChIP-Seq_MCF-7_Human	0.90309907
99	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.90166704
100	SMAD4_21799915_ChIP-Seq_A2780_Human	0.89544932

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004145_abnormal_muscle_electrophysio	4.09140035
2	MP0001348_abnormal_lacrimal_gland	3.67457661
3	MP0001873_stomach_inflammation	3.60282442
4	MP0008057_abnormal_DNA_replication	3.35953852
5	MP0001835_abnormal_antigen_presentation	3.24876752
6	MP0003646_muscle_fatigue	3.04573453
7	MP0004036_abnormal_muscle_relaxation	2.98787329
8	MP0000747_muscle_weakness	2.86586502
9	MP0002837_dystrophic_cardiac_calcinosis	2.69831533
10	MP0004147_increased_porphyrin_level	2.56399980
11	MP0000372_irregular_coat_pigmentation	2.45111580
12	MP0002138_abnormal_hepatobiliary_system	2.37129536
13	MP0006072_abnormal_retinal_apoptosis	2.16466187
14	MP0005379_endocrine/exocrine_gland_phen	2.13664045
15	MP0003959_abnormal_lean_body	2.04089477
16	MP0004043_abnormal_pH_regulation	1.96988758
17	MP0002269_muscular_atrophy	1.96096486
18	MP0001188_hyperpigmentation	1.95329114
19	MP0000749_muscle_degeneration	1.92236972
20	MP0004084_abnormal_cardiac_muscle	1.80093697
21	MP0004782_abnormal_surfactant_physiolog	1.73917973
22	MP0002396_abnormal_hematopoietic_system	1.66815522
23	MP0005620_abnormal_muscle_contractility	1.66800663
24	MP0002106_abnormal_muscle_physiology	1.66073787
25	MP0005645_abnormal_hypothalamus_physiol	1.65924088
26	MP0006292_abnormal_olfactory_placode	1.65810869
27	MP0002163_abnormal_gland_morphology	1.63903248
28	MP0008872_abnormal_physiological_respon	1.61319204
29	MP0002736_abnormal_nociception_after	1.60185822
30	MP0003806_abnormal_nucleotide_metabolis	1.60071442
31	MP0000759_abnormal_skeletal_muscle	1.50432581
32	MP0001501_abnormal_sleep_pattern	1.49473718
33	MP0003786_premature_aging	1.46678532
34	MP0008058_abnormal_DNA_repair	1.46043698
35	MP0009379_abnormal_foot_pigmentation	1.45867470
36	MP0008789_abnormal_olfactory_epithelium	1.42545711
37	MP0002277_abnormal_respiratory_mucosa	1.42313549
38	MP0004142_abnormal_muscle_tone	1.41606939
39	MP0002638_abnormal_pupillary_reflex	1.35137121
40	MP0005671_abnormal_response_to	1.34285914
41	MP0004215_abnormal_myocardial_fiber	1.33982283
42	MP0005075_abnormal_melanosome_morpholog	1.33033631
43	MP0004484_altered_response_of	1.32085741
44	MP0001968_abnormal_touch/_nociception	1.24585686
45	MP0003718_maternal_effect	1.22614535
46	MP0005369_muscle_phenotype	1.20003239
47	MP0001502_abnormal_circadian_rhythm	1.18849167
48	MP0002095_abnormal_skin_pigmentation	1.16766917
49	MP0000613_abnormal_salivary_gland	1.16120705
50	MP0000631_abnormal_neuroendocrine_gland	1.15100854
51	MP0003866_abnormal_defecation	1.13716267
52	MP0002254_reproductive_system_inflammat	1.12768894
53	MP0003936_abnormal_reproductive_system	1.10660015
54	MP0005670_abnormal_white_adipose	1.10130756
55	MP0004087_abnormal_muscle_fiber	1.10070385
56	MP0003787_abnormal_imprinting	1.09743028
57	MP0000685_abnormal_immune_system	1.09054720
58	MP0000627_abnormal_mammary_gland	1.06623809
59	MP0003567_abnormal_fetal_cardiomyocyte	1.06072703
60	MP0002108_abnormal_muscle_morphology	1.06026119
61	MP0009780_abnormal_chondrocyte_physiolo	1.05922911
62	MP0005253_abnormal_eye_physiology	1.05829521
63	MP0008875_abnormal_xenobiotic_pharmacok	1.03763488
64	MP0004885_abnormal_endolymph	1.00916017
65	MP0000049_abnormal_middle_ear	0.92670588
66	MP0003045_fibrosis	0.92312587
67	MP0005551_abnormal_eye_electrophysiolog	0.90276393
68	MP0006036_abnormal_mitochondrial_physio	0.89002789
69	MP0003137_abnormal_impulse_conducting	0.88689198
70	MP0004085_abnormal_heartbeat	0.85988963
71	MP0002234_abnormal_pharynx_morphology	0.85847152
72	MP0009697_abnormal_copulation	0.85731582
73	MP0005387_immune_system_phenotype	0.85641370
74	MP0001790_abnormal_immune_system	0.85641370
75	MP0009333_abnormal_splenocyte_physiolog	0.84937067
76	MP0005377_hearing/vestibular/ear_phenot	0.84479991
77	MP0003878_abnormal_ear_physiology	0.84479991
78	MP0002272_abnormal_nervous_system	0.82913652
79	MP0001661_extended_life_span	0.81036958
80	MP0000427_abnormal_hair_cycle	0.77365246
81	MP0002148_abnormal_hypersensitivity_rea	0.76352663
82	MP0000465_gastrointestinal_hemorrhage	0.76319459
83	MP0002089_abnormal_postnatal_growth/wei	0.74990296
84	MP0009745_abnormal_behavioral_response	0.74287310
85	MP0003186_abnormal_redox_activity	0.71450160
86	MP0003119_abnormal_digestive_system	0.71132708
87	MP0005083_abnormal_biliary_tract	0.70594223
88	MP0001529_abnormal_vocalization	0.69344515
89	MP0005167_abnormal_blood-brain_barrier	0.68775824
90	MP0003880_abnormal_central_pattern	0.68148725
91	MP0004957_abnormal_blastocyst_morpholog	0.67819535
92	MP0002735_abnormal_chemical_nociception	0.65325289
93	MP0002184_abnormal_innervation	0.65318046
94	MP0001663_abnormal_digestive_system	0.65003349
95	MP0006276_abnormal_autonomic_nervous	0.63643426
96	MP0002405_respiratory_system_inflammati	0.63400099
97	MP0001881_abnormal_mammary_gland	0.61255275
98	MP0005636_abnormal_mineral_homeostasis	0.61229863
99	MP0003763_abnormal_thymus_physiology	0.60141328
100	MP0001764_abnormal_homeostasis	0.59460488

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Palpebral edema (HP:0100540)	6.55600761
2	Ulnar deviation of the wrist (HP:0003049)	4.00443204
3	Nemaline bodies (HP:0003798)	3.95611590
4	Round ear (HP:0100830)	3.85887199
5	Hyperkalemia (HP:0002153)	3.85692736
6	Periorbital edema (HP:0100539)	3.61262369
7	Distal arthrogryposis (HP:0005684)	3.59786470
8	Facial edema (HP:0000282)	3.49728202
9	Fibular aplasia (HP:0002990)	3.41577893
10	Absent phalangeal crease (HP:0006109)	3.38054991
11	Exertional dyspnea (HP:0002875)	3.33978161
12	Ketoacidosis (HP:0001993)	3.30393692
13	Muscle fiber inclusion bodies (HP:0100299)	3.11227975
14	Severe combined immunodeficiency (HP:0004430)	3.10322287
15	Mask-like facies (HP:0000298)	3.10053481
16	Deformed tarsal bones (HP:0008119)	3.09902501
17	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	3.06422459
18	Exercise-induced myalgia (HP:0003738)	2.98050310
19	Cerebral palsy (HP:0100021)	2.89104925
20	Abnormal finger flexion creases (HP:0006143)	2.81988319
21	Prominent metopic ridge (HP:0005487)	2.80354256
22	Mesomelia (HP:0003027)	2.78319440
23	3-Methylglutaconic aciduria (HP:0003535)	2.73984250
24	Acute necrotizing encephalopathy (HP:0006965)	2.73481060
25	Abnormal rod and cone electroretinograms (HP:0008323)	2.73416595
26	Calcaneovalgus deformity (HP:0001848)	2.71212706
27	Submucous cleft hard palate (HP:0000176)	2.67055530
28	Thyroiditis (HP:0100646)	2.66711895
29	Congenital, generalized hypertrichosis (HP:0004540)	2.64381313
30	Delayed CNS myelination (HP:0002188)	2.63848502
31	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.61446755
32	Mitochondrial inheritance (HP:0001427)	2.57145816
33	Pancreatic cysts (HP:0001737)	2.55965658
34	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.53392974
35	Abnormality of alanine metabolism (HP:0010916)	2.53392974
36	Hyperalaninemia (HP:0003348)	2.53392974
37	Progressive macrocephaly (HP:0004481)	2.51975811
38	Palpitations (HP:0001962)	2.51824171
39	Increased CSF lactate (HP:0002490)	2.50254665
40	Hypoproteinemia (HP:0003075)	2.49498381
41	Ketosis (HP:0001946)	2.47551260
42	Myopathic facies (HP:0002058)	2.45232593
43	Fatigue (HP:0012378)	2.36035578
44	Posterior subcapsular cataract (HP:0007787)	2.34650053
45	Pancreatic islet-cell hyperplasia (HP:0004510)	2.33442198
46	Increased hepatocellular lipid droplets (HP:0006565)	2.30190795
47	Reduced subcutaneous adipose tissue (HP:0003758)	2.27689392
48	Abnormality of the metopic suture (HP:0005556)	2.26381269
49	Acute encephalopathy (HP:0006846)	2.24897735
50	Adactyly (HP:0009776)	2.20309756
51	Chronic diarrhea (HP:0002028)	2.20240689
52	Abnormality of potassium homeostasis (HP:0011042)	2.18715132
53	CNS hypomyelination (HP:0003429)	2.15494080
54	Hepatocellular necrosis (HP:0001404)	2.13474193
55	Limb hypertonia (HP:0002509)	2.13414138
56	Delayed myelination (HP:0012448)	2.11961709
57	Abnormal mitochondria in muscle tissue (HP:0008316)	2.11176921
58	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.10307420
59	Bile duct proliferation (HP:0001408)	2.08263985
60	Abnormal biliary tract physiology (HP:0012439)	2.08263985
61	Congenital stationary night blindness (HP:0007642)	2.07197957
62	Combined immunodeficiency (HP:0005387)	2.06147024
63	Large for gestational age (HP:0001520)	2.04127567
64	Constricted visual fields (HP:0001133)	2.03929645
65	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.03061892
66	Broad-based gait (HP:0002136)	2.02856135
67	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.02476241
68	Myoglobinuria (HP:0002913)	2.01741413
69	IgG deficiency (HP:0004315)	2.01330044
70	Exercise intolerance (HP:0003546)	1.99029997
71	True hermaphroditism (HP:0010459)	1.96930111
72	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.96819804
73	Testicular atrophy (HP:0000029)	1.95738166
74	Methylmalonic acidemia (HP:0002912)	1.93560724
75	Lipid accumulation in hepatocytes (HP:0006561)	1.93303014
76	2-3 toe syndactyly (HP:0004691)	1.93203139
77	Carpal bone hypoplasia (HP:0001498)	1.93131055
78	Rhabdomyolysis (HP:0003201)	1.91087237
79	Increased serum lactate (HP:0002151)	1.90370699
80	Hypothermia (HP:0002045)	1.90122351
81	Stomatitis (HP:0010280)	1.89185551
82	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.86818303
83	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.86172927
84	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.86108649
85	Volvulus (HP:0002580)	1.82321778
86	Hepatic necrosis (HP:0002605)	1.80949317
87	B lymphocytopenia (HP:0010976)	1.80671169
88	Type II lissencephaly (HP:0007260)	1.80298244
89	Abnormality of macular pigmentation (HP:0008002)	1.79365840
90	Exercise-induced muscle cramps (HP:0003710)	1.77700989
91	Renal Fanconi syndrome (HP:0001994)	1.77272108
92	Nephronophthisis (HP:0000090)	1.75254607
93	Abnormality of eosinophils (HP:0001879)	1.74819823
94	Abnormality of B cell number (HP:0010975)	1.72837053
95	Type 1 muscle fiber predominance (HP:0003803)	1.72395511
96	Atrioventricular block (HP:0001678)	1.71996245
97	Insulin-resistant diabetes mellitus (HP:0000831)	1.71316974
98	Increased intramyocellular lipid droplets (HP:0012240)	1.68418021
99	Metabolic acidosis (HP:0001942)	1.68161542
100	Hyperglycemia (HP:0003074)	1.65595210

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TSSK6	4.07292331
2	TIE1	3.92610483
3	PHKG1	3.29653447
4	PHKG2	3.29653447
5	EIF2AK3	3.00712096
6	VRK2	2.92953260
7	PBK	2.36351659
8	EIF2AK1	2.29070900
9	SRPK1	2.18026942
10	OBSCN	2.14511953
11	NUAK1	2.13483655
12	NLK	2.09193041
13	TXK	2.09139296
14	TRIM28	2.08878894
15	SCYL2	2.07973138
16	TNIK	1.92503500
17	WNK1	1.91167996
18	WNK4	1.80718874
19	FRK	1.75987549
20	WNK3	1.74880987
21	TEC	1.72799760
22	AKT3	1.69455031
23	MAP3K12	1.66027676
24	GRK1	1.65797606
25	MAPK13	1.64051346
26	MST4	1.62822996
27	MAP4K2	1.62217996
28	CASK	1.23552120
29	CSNK1A1L	1.23317889
30	MAP2K6	1.19284799
31	ADRBK2	1.18805624
32	CAMK1D	1.18318287
33	STK16	1.16106348
34	MUSK	1.13317339
35	ZAK	1.13042245
36	EPHA3	1.10623737
37	ITK	1.08657634
38	ERBB3	1.07314199
39	TAF1	1.05013132
40	CSNK1G1	1.03227724
41	TLK1	1.01447210
42	MAPKAPK3	1.00847799
43	DYRK2	0.98745815
44	CSNK1G2	0.97604271
45	MKNK2	0.95263343
46	BCKDK	0.94972242
47	EIF2AK2	0.94674957
48	SIK3	0.92870362
49	CSNK1G3	0.92600376
50	NME1	0.91780184
51	DAPK1	0.89767783
52	IRAK1	0.89601602
53	MKNK1	0.88933101
54	STK4	0.87568009
55	JAK3	0.86840045
56	CAMK1G	0.79832341
57	NME2	0.76492255
58	VRK1	0.76087756
59	EPHA4	0.74885834
60	RPS6KA5	0.72326216
61	PLK3	0.71872956
62	PDK2	0.71655591
63	INSRR	0.69306389
64	PIK3CA	0.69120674
65	TAOK3	0.69002043
66	CCNB1	0.68574497
67	NEK1	0.68098224
68	PAK6	0.64387369
69	DAPK2	0.64073589
70	CAMKK2	0.62489140
71	PRKD3	0.62436884
72	PINK1	0.60085142
73	BMPR1B	0.58922529
74	PAK3	0.56865220
75	MYLK	0.53517891
76	PIK3CG	0.51636840
77	CDK8	0.50966890
78	STK39	0.50225473
79	SGK2	0.48917548
80	DMPK	0.47332938
81	MAPKAPK5	0.44841122
82	SGK1	0.43971803
83	ALK	0.42785395
84	CSNK1A1	0.39609098
85	FES	0.39375821
86	CAMK4	0.38448675
87	CAMK1	0.38005998
88	PRKCE	0.36531103
89	CAMK2G	0.33846936
90	MARK3	0.33186741
91	PRKG1	0.30320346
92	PLK2	0.28386204
93	CSNK1E	0.27825543
94	BRSK2	0.27089584
95	AURKA	0.26472281
96	IKBKE	0.26175996
97	CSNK2A1	0.26020151
98	CHEK2	0.24659891
99	CSNK2A2	0.24553598
100	PRKAA2	0.23114240

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.37878422
2	Proteasome_Homo sapiens_hsa03050	4.25561832
3	Asthma_Homo sapiens_hsa05310	4.09523501
4	Allograft rejection_Homo sapiens_hsa05330	3.95451257
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.44827872
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.98065253
7	Regulation of autophagy_Homo sapiens_hsa04140	2.70551177
8	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.69053235
9	Protein export_Homo sapiens_hsa03060	2.67097790
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.63425247
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.51823340
12	Graft-versus-host disease_Homo sapiens_hsa05332	2.40257958
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.10687394
14	RNA polymerase_Homo sapiens_hsa03020	1.86621186
15	Ribosome_Homo sapiens_hsa03010	1.77004279
16	Basal transcription factors_Homo sapiens_hsa03022	1.75082427
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.69754171
18	RNA transport_Homo sapiens_hsa03013	1.61877780
19	Oxidative phosphorylation_Homo sapiens_hsa00190	1.59816961
20	Spliceosome_Homo sapiens_hsa03040	1.56632115
21	RNA degradation_Homo sapiens_hsa03018	1.52179486
22	Antigen processing and presentation_Homo sapiens_hsa04612	1.39749950
23	Parkinsons disease_Homo sapiens_hsa05012	1.37403040
24	Primary immunodeficiency_Homo sapiens_hsa05340	1.32323147
25	Rheumatoid arthritis_Homo sapiens_hsa05323	1.23420631
26	Tight junction_Homo sapiens_hsa04530	1.18408281
27	Butanoate metabolism_Homo sapiens_hsa00650	1.06040189
28	One carbon pool by folate_Homo sapiens_hsa00670	1.03808633
29	Viral myocarditis_Homo sapiens_hsa05416	1.03652390
30	Cardiac muscle contraction_Homo sapiens_hsa04260	0.93418464
31	Alzheimers disease_Homo sapiens_hsa05010	0.93085791
32	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.90747796
33	Sulfur metabolism_Homo sapiens_hsa00920	0.90459327
34	Huntingtons disease_Homo sapiens_hsa05016	0.90036519
35	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.89073294
36	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.87611175
37	Insulin secretion_Homo sapiens_hsa04911	0.83935329
38	Purine metabolism_Homo sapiens_hsa00230	0.80903834
39	Peroxisome_Homo sapiens_hsa04146	0.77287250
40	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.76101747
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.74944991
42	Phototransduction_Homo sapiens_hsa04744	0.74887970
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.74682412
44	Salivary secretion_Homo sapiens_hsa04970	0.74515848
45	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.73007612
46	Calcium signaling pathway_Homo sapiens_hsa04020	0.72532792
47	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.72368979
48	Measles_Homo sapiens_hsa05162	0.70765783
49	Mineral absorption_Homo sapiens_hsa04978	0.68831222
50	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.68246244
51	Fanconi anemia pathway_Homo sapiens_hsa03460	0.68177132
52	mRNA surveillance pathway_Homo sapiens_hsa03015	0.67421453
53	Glucagon signaling pathway_Homo sapiens_hsa04922	0.66561453
54	Pyrimidine metabolism_Homo sapiens_hsa00240	0.66504534
55	Linoleic acid metabolism_Homo sapiens_hsa00591	0.65318999
56	Nucleotide excision repair_Homo sapiens_hsa03420	0.65181843
57	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.59924954
58	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.59585824
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.59111897
60	DNA replication_Homo sapiens_hsa03030	0.57959268
61	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.55658572
62	Circadian rhythm_Homo sapiens_hsa04710	0.54387865
63	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.54384028
64	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.54072219
65	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.53996919
66	Glutathione metabolism_Homo sapiens_hsa00480	0.52307700
67	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.51152847
68	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.51024544
69	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.50487754
70	Circadian entrainment_Homo sapiens_hsa04713	0.49660421
71	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.49255616
72	Non-homologous end-joining_Homo sapiens_hsa03450	0.48253655
73	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.48012111
74	Renin secretion_Homo sapiens_hsa04924	0.47652582
75	Folate biosynthesis_Homo sapiens_hsa00790	0.47268365
76	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.47215111
77	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.45760021
78	Propanoate metabolism_Homo sapiens_hsa00640	0.44612796
79	Long-term depression_Homo sapiens_hsa04730	0.38608248
80	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.37963728
81	Olfactory transduction_Homo sapiens_hsa04740	0.37956688
82	Selenocompound metabolism_Homo sapiens_hsa00450	0.36719239
83	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.36659363
84	Gastric acid secretion_Homo sapiens_hsa04971	0.36443018
85	Oocyte meiosis_Homo sapiens_hsa04114	0.35752784
86	Homologous recombination_Homo sapiens_hsa03440	0.34727211
87	Pancreatic secretion_Homo sapiens_hsa04972	0.33557751
88	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.26893755
89	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.25968546
90	Wnt signaling pathway_Homo sapiens_hsa04310	0.25838193
91	Chemical carcinogenesis_Homo sapiens_hsa05204	0.25619282
92	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.25368577
93	Herpes simplex infection_Homo sapiens_hsa05168	0.25339148
94	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.25100787
95	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.24273221
96	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.23347815
97	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.22046225
98	Metabolic pathways_Homo sapiens_hsa01100	0.21237245
99	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.20020395
100	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.19799198

RPL29P24

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »