ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.98679098
2	fucose catabolic process (GO:0019317)	4.57739216
3	L-fucose metabolic process (GO:0042354)	4.57739216
4	L-fucose catabolic process (GO:0042355)	4.57739216
5	DNA deamination (GO:0045006)	4.48317838
6	response to pheromone (GO:0019236)	4.46255121
7	negative regulation of telomere maintenance (GO:0032205)	4.17511410
8	water-soluble vitamin biosynthetic process (GO:0042364)	3.88594532
9	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.56837328
10	ATP synthesis coupled proton transport (GO:0015986)	3.56837328
11	protein polyglutamylation (GO:0018095)	3.41858576
12	negative regulation of mast cell activation (GO:0033004)	3.41108273
13	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.28321763
14	chaperone-mediated protein transport (GO:0072321)	3.25647621
15	protein-cofactor linkage (GO:0018065)	3.16631907
16	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.16269699
17	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.13534979
18	platelet dense granule organization (GO:0060155)	3.12642942
19	glycerophospholipid catabolic process (GO:0046475)	3.11167405
20	nucleoside transmembrane transport (GO:1901642)	3.07130082
21	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.04916564
22	NADH dehydrogenase complex assembly (GO:0010257)	3.04916564
23	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.04916564
24	gamma-aminobutyric acid transport (GO:0015812)	3.02955218
25	protein complex biogenesis (GO:0070271)	3.00841578
26	indolalkylamine metabolic process (GO:0006586)	2.98647548
27	detection of light stimulus involved in sensory perception (GO:0050962)	2.97410145
28	detection of light stimulus involved in visual perception (GO:0050908)	2.97410145
29	epithelial cilium movement (GO:0003351)	2.97173874
30	transmission of nerve impulse (GO:0019226)	2.94803582
31	behavioral response to ethanol (GO:0048149)	2.94352826
32	indole-containing compound catabolic process (GO:0042436)	2.89753823
33	indolalkylamine catabolic process (GO:0046218)	2.89753823
34	tryptophan catabolic process (GO:0006569)	2.89753823
35	axoneme assembly (GO:0035082)	2.89084848
36	kynurenine metabolic process (GO:0070189)	2.86668582
37	kidney morphogenesis (GO:0060993)	2.84552864
38	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.84219667
39	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.78757174
40	respiratory chain complex IV assembly (GO:0008535)	2.76989165
41	nonmotile primary cilium assembly (GO:0035058)	2.76787318
42	somite development (GO:0061053)	2.76757480
43	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.76243800
44	regulation of neurotransmitter uptake (GO:0051580)	2.75857038
45	mitochondrial respiratory chain complex assembly (GO:0033108)	2.75714882
46	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.75478039
47	preassembly of GPI anchor in ER membrane (GO:0016254)	2.75281421
48	pyrimidine nucleobase catabolic process (GO:0006208)	2.74715913
49	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.74082410
50	cellular biogenic amine catabolic process (GO:0042402)	2.74012229
51	amine catabolic process (GO:0009310)	2.74012229
52	rhodopsin mediated signaling pathway (GO:0016056)	2.72859438
53	synaptic transmission, cholinergic (GO:0007271)	2.72781154
54	sulfation (GO:0051923)	2.72602596
55	cytidine metabolic process (GO:0046087)	2.72380744
56	cytidine catabolic process (GO:0006216)	2.72380744
57	cytidine deamination (GO:0009972)	2.72380744
58	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.70921988
59	regulation of action potential (GO:0098900)	2.69768717
60	protein neddylation (GO:0045116)	2.69664094
61	ubiquinone biosynthetic process (GO:0006744)	2.68619492
62	cilium morphogenesis (GO:0060271)	2.67648883
63	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.67072439
64	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.67072439
65	neuronal action potential (GO:0019228)	2.66938629
66	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.62493478
67	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.61499129
68	piRNA metabolic process (GO:0034587)	2.59000841
69	positive regulation of fatty acid transport (GO:2000193)	2.58937195
70	protein deneddylation (GO:0000338)	2.56582152
71	interferon-gamma production (GO:0032609)	2.55885284
72	head development (GO:0060322)	2.55019704
73	regulation of telomere maintenance (GO:0032204)	2.52607132
74	ubiquinone metabolic process (GO:0006743)	2.51150918
75	GPI anchor metabolic process (GO:0006505)	2.50775795
76	neural tube formation (GO:0001841)	2.50070045
77	protein localization to cilium (GO:0061512)	2.49596088
78	cellular ketone body metabolic process (GO:0046950)	2.49314748
79	retinal cone cell development (GO:0046549)	2.48319315
80	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.47777586
81	reflex (GO:0060004)	2.46862582
82	multicellular organism reproduction (GO:0032504)	2.46335771
83	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.45031038
84	cytochrome complex assembly (GO:0017004)	2.44186524
85	intracellular protein transmembrane import (GO:0044743)	2.43658787
86	cornea development in camera-type eye (GO:0061303)	2.42684216
87	nucleobase catabolic process (GO:0046113)	2.39158442
88	cilium organization (GO:0044782)	2.38776635
89	parturition (GO:0007567)	2.38583296
90	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.38505590
91	proton transport (GO:0015992)	2.38250989
92	cellular response to ATP (GO:0071318)	2.36432412
93	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.35520430
94	hydrogen ion transmembrane transport (GO:1902600)	2.34005589
95	cilium assembly (GO:0042384)	2.33825165
96	fucosylation (GO:0036065)	2.33748722
97	positive regulation of defense response to virus by host (GO:0002230)	2.33668399
98	cAMP catabolic process (GO:0006198)	2.33497407
99	regulation of cilium movement (GO:0003352)	2.32455210
100	hydrogen transport (GO:0006818)	2.31723088

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.26947408
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.55716586
3	VDR_22108803_ChIP-Seq_LS180_Human	3.19384860
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.89898020
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.84409566
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.71351996
7	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.62774010
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.47762130
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.41850262
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.32087286
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.11946188
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.08805150
13	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.07520722
14	FUS_26573619_Chip-Seq_HEK293_Human	2.05882561
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.02278255
16	EWS_26573619_Chip-Seq_HEK293_Human	2.01851376
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.99321631
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.95842700
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.92400462
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.87512602
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.86984253
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.85539614
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.84158721
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.79074655
25	P300_19829295_ChIP-Seq_ESCs_Human	1.78967931
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.77578544
27	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.70833222
28	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.70701465
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.69262346
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.67522325
31	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.65936958
32	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.64699411
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.54772024
34	RNF2_27304074_Chip-Seq_NSC_Mouse	1.51842756
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50281852
36	REST_21632747_ChIP-Seq_MESCs_Mouse	1.48122507
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.48058122
38	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.45816451
39	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.43959002
40	IRF1_19129219_ChIP-ChIP_H3396_Human	1.40626727
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.40428913
42	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.40250351
43	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.34267758
44	AR_25329375_ChIP-Seq_VCAP_Human	1.34151002
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.33915567
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.33915567
47	BCAT_22108803_ChIP-Seq_LS180_Human	1.32686976
48	NCOR_22424771_ChIP-Seq_293T_Human	1.30794893
49	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.30481317
50	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.29464964
51	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.27039558
52	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26638180
53	STAT3_23295773_ChIP-Seq_U87_Human	1.26572246
54	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.26476416
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.26476416
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.26409646
57	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.24427173
58	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.20598528
59	TCF4_23295773_ChIP-Seq_U87_Human	1.19147491
60	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18206110
61	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.18206110
62	TCF4_22108803_ChIP-Seq_LS180_Human	1.17875067
63	SMAD4_21799915_ChIP-Seq_A2780_Human	1.16659019
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16572793
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16572793
66	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.16311895
67	ELK1_19687146_ChIP-ChIP_HELA_Human	1.15732905
68	HOXB7_26014856_ChIP-Seq_BT474_Human	1.15244523
69	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.13935918
70	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.12965820
71	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.12890787
72	AR_21572438_ChIP-Seq_LNCaP_Human	1.12804299
73	AR_20517297_ChIP-Seq_VCAP_Human	1.11346677
74	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.10829337
75	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.10537759
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10051730
77	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.09997500
78	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09304132
79	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.08913296
80	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.07931942
81	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.07788534
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06879832
83	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.05986891
84	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05410188
85	ERA_21632823_ChIP-Seq_H3396_Human	1.04811786
86	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.04490443
87	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04453745
88	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.03334076
89	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.02547634
90	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.02187933
91	MYC_19829295_ChIP-Seq_ESCs_Human	1.02151985
92	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.00886061
93	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.99956005
94	VDR_23849224_ChIP-Seq_CD4+_Human	0.99922445
95	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.98722066
96	NANOG_20526341_ChIP-Seq_ESCs_Human	0.96969292
97	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.96200990
98	TAF2_19829295_ChIP-Seq_ESCs_Human	0.95349514
99	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94731348
100	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.94629520

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.88715894
2	MP0002638_abnormal_pupillary_reflex	2.83416099
3	MP0002102_abnormal_ear_morphology	2.72528146
4	MP0004133_heterotaxia	2.55832208
5	MP0005551_abnormal_eye_electrophysiolog	2.55592100
6	MP0003646_muscle_fatigue	2.47610014
7	MP0003195_calcinosis	2.40898877
8	MP0006072_abnormal_retinal_apoptosis	2.38045953
9	MP0003011_delayed_dark_adaptation	2.23333660
10	MP0001968_abnormal_touch/_nociception	2.23155570
11	MP0005645_abnormal_hypothalamus_physiol	2.12791733
12	MP0003787_abnormal_imprinting	2.05772742
13	MP0004885_abnormal_endolymph	2.01932997
14	MP0001986_abnormal_taste_sensitivity	2.01875854
15	MP0009046_muscle_twitch	1.98217628
16	MP0008875_abnormal_xenobiotic_pharmacok	1.97665146
17	MP0004043_abnormal_pH_regulation	1.95735627
18	MP0001485_abnormal_pinna_reflex	1.94731061
19	MP0009745_abnormal_behavioral_response	1.92435412
20	MP0005253_abnormal_eye_physiology	1.90564780
21	MP0002876_abnormal_thyroid_physiology	1.84956474
22	MP0002272_abnormal_nervous_system	1.82439840
23	MP0002837_dystrophic_cardiac_calcinosis	1.79984723
24	MP0008872_abnormal_physiological_respon	1.79222645
25	MP0006292_abnormal_olfactory_placode	1.74807036
26	MP0004142_abnormal_muscle_tone	1.74348719
27	MP0002736_abnormal_nociception_after	1.73261993
28	MP0008995_early_reproductive_senescence	1.72757577
29	MP0004742_abnormal_vestibular_system	1.64778199
30	MP0006276_abnormal_autonomic_nervous	1.63237116
31	MP0005646_abnormal_pituitary_gland	1.61142437
32	MP0005377_hearing/vestibular/ear_phenot	1.60062686
33	MP0003878_abnormal_ear_physiology	1.60062686
34	MP0001529_abnormal_vocalization	1.59824113
35	MP0004145_abnormal_muscle_electrophysio	1.51743555
36	MP0002160_abnormal_reproductive_system	1.51055459
37	MP0003880_abnormal_central_pattern	1.49179155
38	MP0002735_abnormal_chemical_nociception	1.48974077
39	MP0001486_abnormal_startle_reflex	1.46803419
40	MP0002938_white_spotting	1.46740844
41	MP0001501_abnormal_sleep_pattern	1.45108153
42	MP0003136_yellow_coat_color	1.41180283
43	MP0005389_reproductive_system_phenotype	1.40516780
44	MP0002572_abnormal_emotion/affect_behav	1.39537224
45	MP0000631_abnormal_neuroendocrine_gland	1.38117787
46	MP0002557_abnormal_social/conspecific_i	1.37677927
47	MP0003122_maternal_imprinting	1.33366383
48	MP0002733_abnormal_thermal_nociception	1.32526336
49	MP0001984_abnormal_olfaction	1.29010759
50	MP0002064_seizures	1.27641157
51	MP0000372_irregular_coat_pigmentation	1.25965625
52	MP0000569_abnormal_digit_pigmentation	1.24306646
53	MP0000427_abnormal_hair_cycle	1.24215727
54	MP0002653_abnormal_ependyma_morphology	1.23722428
55	MP0005195_abnormal_posterior_eye	1.22669755
56	MP0003121_genomic_imprinting	1.16013419
57	MP0001919_abnormal_reproductive_system	1.15362327
58	MP0001502_abnormal_circadian_rhythm	1.15062600
59	MP0001970_abnormal_pain_threshold	1.14789287
60	MP0005174_abnormal_tail_pigmentation	1.14495414
61	MP0003635_abnormal_synaptic_transmissio	1.13521741
62	MP0002184_abnormal_innervation	1.13422567
63	MP0002734_abnormal_mechanical_nocicepti	1.12809099
64	MP0002063_abnormal_learning/memory/cond	1.11007035
65	MP0000778_abnormal_nervous_system	1.10448925
66	MP0005084_abnormal_gallbladder_morpholo	1.10121786
67	MP0008789_abnormal_olfactory_epithelium	1.09961356
68	MP0008058_abnormal_DNA_repair	1.08941735
69	MP0005386_behavior/neurological_phenoty	1.08916655
70	MP0004924_abnormal_behavior	1.08916655
71	MP0003890_abnormal_embryonic-extraembry	1.08756153
72	MP0002067_abnormal_sensory_capabilities	1.07715719
73	MP0002752_abnormal_somatic_nervous	1.06647512
74	MP0005423_abnormal_somatic_nervous	1.05322268
75	MP0002751_abnormal_autonomic_nervous	1.04987315
76	MP0001905_abnormal_dopamine_level	1.04636976
77	MP0009379_abnormal_foot_pigmentation	1.03108908
78	MP0005379_endocrine/exocrine_gland_phen	0.99988201
79	MP0001324_abnormal_eye_pigmentation	0.97588930
80	MP0000647_abnormal_sebaceous_gland	0.94922124
81	MP0000049_abnormal_middle_ear	0.93668520
82	MP0000026_abnormal_inner_ear	0.92692059
83	MP0004270_analgesia	0.92103851
84	MP0008775_abnormal_heart_ventricle	0.90180872
85	MP0005167_abnormal_blood-brain_barrier	0.90134126
86	MP0002163_abnormal_gland_morphology	0.90036824
87	MP0002234_abnormal_pharynx_morphology	0.89278955
88	MP0004147_increased_porphyrin_level	0.88707789
89	MP0003119_abnormal_digestive_system	0.88547672
90	MP0002095_abnormal_skin_pigmentation	0.87043034
91	MP0001963_abnormal_hearing_physiology	0.86247218
92	MP0000230_abnormal_systemic_arterial	0.85958957
93	MP0002928_abnormal_bile_duct	0.85847524
94	MP0003937_abnormal_limbs/digits/tail_de	0.84921609
95	MP0000955_abnormal_spinal_cord	0.84719063
96	MP0010386_abnormal_urinary_bladder	0.84596302
97	MP0004019_abnormal_vitamin_homeostasis	0.82335808
98	MP0003137_abnormal_impulse_conducting	0.82073966
99	MP0003283_abnormal_digestive_organ	0.81499835
100	MP0000383_abnormal_hair_follicle	0.80812396

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of midbrain morphology (HP:0002418)	4.26003910
2	Molar tooth sign on MRI (HP:0002419)	4.26003910
3	Pancreatic cysts (HP:0001737)	4.21920989
4	Congenital stationary night blindness (HP:0007642)	4.07504769
5	True hermaphroditism (HP:0010459)	3.99837246
6	Pancreatic fibrosis (HP:0100732)	3.79091106
7	Nephronophthisis (HP:0000090)	3.33439926
8	Type II lissencephaly (HP:0007260)	3.07972422
9	Pendular nystagmus (HP:0012043)	2.99070319
10	Hyperventilation (HP:0002883)	2.93225870
11	Medial flaring of the eyebrow (HP:0010747)	2.91581191
12	Methylmalonic acidemia (HP:0002912)	2.84866173
13	Abnormal rod and cone electroretinograms (HP:0008323)	2.84674882
14	Abnormality of the renal medulla (HP:0100957)	2.82197251
15	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.80242899
16	Abnormality of alanine metabolism (HP:0010916)	2.80242899
17	Hyperalaninemia (HP:0003348)	2.80242899
18	Chronic hepatic failure (HP:0100626)	2.61781825
19	Abnormality of the renal cortex (HP:0011035)	2.59860131
20	Mitochondrial inheritance (HP:0001427)	2.59565752
21	Abolished electroretinogram (ERG) (HP:0000550)	2.55569436
22	Polydipsia (HP:0001959)	2.55445814
23	Abnormal drinking behavior (HP:0030082)	2.55445814
24	Sclerocornea (HP:0000647)	2.54350170
25	Cystic liver disease (HP:0006706)	2.54090012
26	Inability to walk (HP:0002540)	2.52331246
27	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.52034136
28	Gait imbalance (HP:0002141)	2.50718511
29	Increased CSF lactate (HP:0002490)	2.49185346
30	Lipid accumulation in hepatocytes (HP:0006561)	2.40707763
31	Increased hepatocellular lipid droplets (HP:0006565)	2.40444300
32	Congenital, generalized hypertrichosis (HP:0004540)	2.39694195
33	Methylmalonic aciduria (HP:0012120)	2.39238241
34	Congenital primary aphakia (HP:0007707)	2.37976797
35	Attenuation of retinal blood vessels (HP:0007843)	2.35447023
36	Acute necrotizing encephalopathy (HP:0006965)	2.33929933
37	Hyperglycinemia (HP:0002154)	2.33915768
38	Anencephaly (HP:0002323)	2.26354890
39	Male pseudohermaphroditism (HP:0000037)	2.25850540
40	Large for gestational age (HP:0001520)	2.25488688
41	Abnormality of the pons (HP:0007361)	2.21022549
42	Tubular atrophy (HP:0000092)	2.16917131
43	Progressive cerebellar ataxia (HP:0002073)	2.15800509
44	Hypoplasia of the pons (HP:0012110)	2.15197114
45	Nephrogenic diabetes insipidus (HP:0009806)	2.14731689
46	Decreased central vision (HP:0007663)	2.12835554
47	Progressive macrocephaly (HP:0004481)	2.12272984
48	Delayed CNS myelination (HP:0002188)	2.11985022
49	Hepatocellular necrosis (HP:0001404)	2.11626448
50	Polyuria (HP:0000103)	2.11091078
51	Acute encephalopathy (HP:0006846)	2.10421735
52	3-Methylglutaconic aciduria (HP:0003535)	2.09983918
53	Agitation (HP:0000713)	2.07670072
54	Keratoconus (HP:0000563)	2.07633460
55	Increased corneal curvature (HP:0100692)	2.07633460
56	Lissencephaly (HP:0001339)	2.07550876
57	Optic disc pallor (HP:0000543)	2.06687326
58	Progressive inability to walk (HP:0002505)	2.04404939
59	Abnormal biliary tract physiology (HP:0012439)	2.02213792
60	Bile duct proliferation (HP:0001408)	2.02213792
61	Clumsiness (HP:0002312)	2.01232744
62	Concave nail (HP:0001598)	1.99381684
63	Renal Fanconi syndrome (HP:0001994)	1.98472198
64	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.95868239
65	Cerebellar dysplasia (HP:0007033)	1.95613805
66	Dyskinesia (HP:0100660)	1.95028550
67	Furrowed tongue (HP:0000221)	1.94831720
68	Broad-based gait (HP:0002136)	1.94362098
69	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.92895098
70	Abnormal mitochondria in muscle tissue (HP:0008316)	1.92639609
71	Optic nerve hypoplasia (HP:0000609)	1.92609219
72	Genital tract atresia (HP:0001827)	1.92468963
73	Renal cortical cysts (HP:0000803)	1.92069925
74	Bony spicule pigmentary retinopathy (HP:0007737)	1.91032918
75	Vaginal atresia (HP:0000148)	1.90750175
76	Patellar aplasia (HP:0006443)	1.90692776
77	Global brain atrophy (HP:0002283)	1.89735970
78	Decreased circulating renin level (HP:0003351)	1.89155842
79	Abnormality of serine family amino acid metabolism (HP:0010894)	1.88307782
80	Abnormality of glycine metabolism (HP:0010895)	1.88307782
81	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.87980608
82	Hepatic necrosis (HP:0002605)	1.87838171
83	Increased serum lactate (HP:0002151)	1.85723225
84	Severe muscular hypotonia (HP:0006829)	1.85486180
85	Aplasia/Hypoplasia of the patella (HP:0006498)	1.85148253
86	Rib fusion (HP:0000902)	1.83683308
87	Congenital hepatic fibrosis (HP:0002612)	1.83287895
88	Hypoplasia of the fovea (HP:0007750)	1.82848636
89	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.82848636
90	Hyperglycinuria (HP:0003108)	1.80991519
91	Hemiparesis (HP:0001269)	1.79990948
92	Abnormal number of erythroid precursors (HP:0012131)	1.78154867
93	Exertional dyspnea (HP:0002875)	1.77071450
94	Pachygyria (HP:0001302)	1.76956249
95	Retinitis pigmentosa (HP:0000510)	1.75728814
96	Abnormality of renal resorption (HP:0011038)	1.74662576
97	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.73207420
98	Absent/shortened dynein arms (HP:0200106)	1.73207420
99	Limb dystonia (HP:0002451)	1.72964196
100	Amblyopia (HP:0000646)	1.71897613

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.96772300
2	TLK1	3.22301538
3	ADRBK2	2.94643168
4	MAP4K2	2.92826738
5	WNK4	2.85525128
6	GRK1	2.82671661
7	ZAK	2.81169269
8	WNK3	2.37323906
9	TXK	2.34113350
10	BMPR1B	2.29172573
11	MAP2K6	2.25616423
12	MAPK13	2.06862321
13	CASK	1.99233257
14	PINK1	1.97829635
15	NUAK1	1.89621223
16	INSRR	1.86773281
17	STK39	1.86203258
18	TAOK3	1.77965315
19	MAP3K4	1.65900137
20	OXSR1	1.59412352
21	VRK2	1.58764976
22	MARK1	1.54674066
23	ACVR1B	1.47843355
24	PAK3	1.45528694
25	DAPK2	1.41270072
26	DYRK2	1.32871035
27	MAP2K7	1.32311832
28	MKNK2	1.25462046
29	CAMKK2	1.20608068
30	STK16	1.16696721
31	SIK2	1.12213966
32	NEK2	1.11863331
33	ADRBK1	1.09603045
34	PRKCG	1.09511761
35	MAPKAPK5	1.07483612
36	VRK1	1.01171308
37	WEE1	0.94651127
38	TGFBR1	0.94530958
39	TNIK	0.91137817
40	CSNK1G2	0.90414807
41	EPHA3	0.89272202
42	PRKCE	0.88800915
43	BCKDK	0.88793835
44	CSNK1G1	0.87388374
45	NTRK2	0.85572545
46	NME1	0.85253372
47	PHKG1	0.81639472
48	PHKG2	0.81639472
49	MKNK1	0.81620835
50	CSNK1G3	0.80917975
51	PNCK	0.80649708
52	MAPK15	0.80397132
53	NTRK3	0.75534415
54	STK38L	0.74421230
55	PLK2	0.73939069
56	TAF1	0.72183121
57	BRSK2	0.71298373
58	PDK2	0.69362670
59	PRKCQ	0.68965083
60	MAP2K4	0.65277263
61	PLK3	0.65187558
62	BCR	0.63595442
63	CAMK2A	0.61783619
64	NLK	0.60878303
65	ERBB3	0.59715716
66	PIK3CA	0.59272621
67	GRK7	0.59106786
68	CSNK1A1L	0.56879884
69	PKN1	0.54305374
70	MINK1	0.53555579
71	PRKCI	0.53390583
72	GRK5	0.52325338
73	TAOK2	0.51585275
74	TIE1	0.50063979
75	RPS6KA5	0.50061712
76	TRIM28	0.49896525
77	PRKACA	0.49886726
78	KIT	0.47896792
79	CSNK1A1	0.43591181
80	FGFR2	0.43306617
81	MUSK	0.42942799
82	DYRK3	0.42485427
83	DYRK1A	0.40180663
84	EPHA4	0.39820412
85	MAP3K5	0.39353573
86	EIF2AK3	0.38126604
87	PRKCA	0.37390870
88	IKBKB	0.36898460
89	PASK	0.36598170
90	SGK2	0.36582367
91	CAMK1	0.36348446
92	CCNB1	0.35484460
93	TSSK6	0.35410219
94	TEC	0.34691371
95	ABL2	0.34435551
96	IRAK1	0.34194783
97	PRKCZ	0.32310046
98	MST4	0.31728374
99	PAK6	0.31035965
100	ITK	0.30673176

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Linoleic acid metabolism_Homo sapiens_hsa00591	2.96973184
2	Phototransduction_Homo sapiens_hsa04744	2.95732693
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.91373921
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.87396661
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.44567170
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.37205943
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.36968739
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.32170584
9	Parkinsons disease_Homo sapiens_hsa05012	2.26688579
10	Nicotine addiction_Homo sapiens_hsa05033	2.15459383
11	Ether lipid metabolism_Homo sapiens_hsa00565	2.12763087
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.09506466
13	Butanoate metabolism_Homo sapiens_hsa00650	2.05929189
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.04792051
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.04594539
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.87931358
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.86270689
18	Ribosome_Homo sapiens_hsa03010	1.64585576
19	Basal transcription factors_Homo sapiens_hsa03022	1.61751831
20	Protein export_Homo sapiens_hsa03060	1.58445168
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.53551451
22	Cardiac muscle contraction_Homo sapiens_hsa04260	1.49442570
23	Homologous recombination_Homo sapiens_hsa03440	1.48907115
24	Alzheimers disease_Homo sapiens_hsa05010	1.45927770
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.45460027
26	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.40036592
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.38613717
28	Huntingtons disease_Homo sapiens_hsa05016	1.37928437
29	RNA polymerase_Homo sapiens_hsa03020	1.32825321
30	Regulation of autophagy_Homo sapiens_hsa04140	1.31089323
31	Propanoate metabolism_Homo sapiens_hsa00640	1.29090755
32	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.27542818
33	RNA degradation_Homo sapiens_hsa03018	1.24710310
34	Peroxisome_Homo sapiens_hsa04146	1.24048687
35	Morphine addiction_Homo sapiens_hsa05032	1.20654834
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.18563159
37	Caffeine metabolism_Homo sapiens_hsa00232	1.18399996
38	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.14879297
39	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.14142454
40	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.10105739
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.08933637
42	Olfactory transduction_Homo sapiens_hsa04740	1.08571166
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.06053896
44	Taste transduction_Homo sapiens_hsa04742	1.04110475
45	Sulfur metabolism_Homo sapiens_hsa00920	1.03209408
46	GABAergic synapse_Homo sapiens_hsa04727	0.98016657
47	Fat digestion and absorption_Homo sapiens_hsa04975	0.97856719
48	Chemical carcinogenesis_Homo sapiens_hsa05204	0.97125362
49	Retinol metabolism_Homo sapiens_hsa00830	0.93280072
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92274792
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.91669211
52	Asthma_Homo sapiens_hsa05310	0.89752399
53	One carbon pool by folate_Homo sapiens_hsa00670	0.89555470
54	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.89375791
55	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.89367668
56	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.86779022
57	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.84710573
58	Circadian entrainment_Homo sapiens_hsa04713	0.83643238
59	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.82558413
60	Serotonergic synapse_Homo sapiens_hsa04726	0.79971586
61	Proteasome_Homo sapiens_hsa03050	0.77083353
62	Glutamatergic synapse_Homo sapiens_hsa04724	0.76251886
63	Collecting duct acid secretion_Homo sapiens_hsa04966	0.74677175
64	Insulin secretion_Homo sapiens_hsa04911	0.73622902
65	ABC transporters_Homo sapiens_hsa02010	0.73297287
66	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.72776923
67	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.72745132
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.72491105
69	Steroid biosynthesis_Homo sapiens_hsa00100	0.68130947
70	Metabolic pathways_Homo sapiens_hsa01100	0.62775355
71	Purine metabolism_Homo sapiens_hsa00230	0.62658565
72	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.56653455
73	Cocaine addiction_Homo sapiens_hsa05030	0.56196042
74	beta-Alanine metabolism_Homo sapiens_hsa00410	0.54677379
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.54133875
76	Primary immunodeficiency_Homo sapiens_hsa05340	0.53967235
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.53578283
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.52536242
79	Type I diabetes mellitus_Homo sapiens_hsa04940	0.52378944
80	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.51194657
81	Long-term depression_Homo sapiens_hsa04730	0.50989234
82	Dopaminergic synapse_Homo sapiens_hsa04728	0.50018823
83	Salivary secretion_Homo sapiens_hsa04970	0.48350848
84	Histidine metabolism_Homo sapiens_hsa00340	0.47882433
85	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.47044003
86	Allograft rejection_Homo sapiens_hsa05330	0.46946974
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.44845372
88	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.44494273
89	Sulfur relay system_Homo sapiens_hsa04122	0.42570484
90	Pyrimidine metabolism_Homo sapiens_hsa00240	0.41522589
91	Fatty acid elongation_Homo sapiens_hsa00062	0.41386615
92	Graft-versus-host disease_Homo sapiens_hsa05332	0.41371424
93	Calcium signaling pathway_Homo sapiens_hsa04020	0.41042090
94	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.36481964
95	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.35554808
96	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.34640397
97	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.33906492
98	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.33330897
99	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.33287182
100	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.32817092

RPL29P25

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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