RPL29P28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of natural killer cell differentiation (GO:0032825)7.15083600
2regulation of isotype switching to IgG isotypes (GO:0048302)7.04806921
3positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)6.87395834
4regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)5.92685527
5negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)5.77644933
6negative regulation of T-helper cell differentiation (GO:0045623)5.77644933
7positive regulation of interleukin-17 production (GO:0032740)5.50835798
8positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.47722633
9positive regulation of chemokine biosynthetic process (GO:0045080)5.43927993
10CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)5.43156783
11proteasome assembly (GO:0043248)5.37650995
12regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)5.15062980
13regulation of podosome assembly (GO:0071801)5.12664769
14regulation of MHC class II biosynthetic process (GO:0045346)5.10324539
15regulation of immunoglobulin secretion (GO:0051023)5.04342880
16negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.79204232
17regulation of natural killer cell differentiation (GO:0032823)4.78854772
18regulation of chronic inflammatory response (GO:0002676)4.78308812
19positive regulation of isotype switching (GO:0045830)4.64602473
20alpha-beta T cell activation involved in immune response (GO:0002287)4.44201077
21T cell differentiation involved in immune response (GO:0002292)4.44201077
22alpha-beta T cell differentiation involved in immune response (GO:0002293)4.44201077
23negative regulation of alpha-beta T cell differentiation (GO:0046639)4.40639210
24positive regulation of DNA recombination (GO:0045911)4.37738030
25pseudouridine synthesis (GO:0001522)4.37455098
26positive regulation of immunoglobulin production (GO:0002639)4.20088891
27regulation of chemokine biosynthetic process (GO:0045073)4.13224876
28regulation of immunoglobulin production (GO:0002637)4.12232109
29positive regulation of interleukin-10 production (GO:0032733)4.10073970
30viral mRNA export from host cell nucleus (GO:0046784)4.08475446
31DNA deamination (GO:0045006)4.06819159
32defense response to protozoan (GO:0042832)4.05586475
33regulation of interleukin-17 production (GO:0032660)3.84317380
34regulation of vitamin D biosynthetic process (GO:0060556)3.71160583
35cellular response to interleukin-15 (GO:0071350)3.70813601
36regulation of isotype switching (GO:0045191)3.69075464
37regulation of proton transport (GO:0010155)3.66415636
38peptidyl-histidine modification (GO:0018202)3.61027112
39chaperone-mediated protein transport (GO:0072321)3.59703759
40response to protozoan (GO:0001562)3.48306505
41production of molecular mediator of immune response (GO:0002440)3.46903005
42ATP synthesis coupled proton transport (GO:0015986)3.40740774
43energy coupled proton transport, down electrochemical gradient (GO:0015985)3.40740774
44response to interleukin-15 (GO:0070672)3.38287971
45positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.35063672
46positive regulation of B cell proliferation (GO:0030890)3.32916859
47CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.32375355
48T-helper cell differentiation (GO:0042093)3.32375355
49termination of RNA polymerase III transcription (GO:0006386)3.28936374
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.28936374
51T cell lineage commitment (GO:0002360)3.26633308
52rRNA modification (GO:0000154)3.24632922
53positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.24066899
54mitochondrial RNA metabolic process (GO:0000959)3.23238501
55regulation of interleukin-12 biosynthetic process (GO:0045075)3.21427123
56rRNA methylation (GO:0031167)3.19981687
57regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.18809878
58regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.16160999
59positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.16160999
60positive regulation of natural killer cell activation (GO:0032816)3.15998074
61positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)3.14448648
62positive regulation of natural killer cell mediated immunity (GO:0002717)3.12874096
63GTP biosynthetic process (GO:0006183)3.11559529
64protein neddylation (GO:0045116)3.05889073
65somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.04889804
66isotype switching (GO:0045190)3.04889804
67somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.04889804
68retinal cone cell development (GO:0046549)3.02320777
69negative regulation of nitric oxide biosynthetic process (GO:0045019)3.00496040
70positive regulation of B cell mediated immunity (GO:0002714)3.00481667
71positive regulation of immunoglobulin mediated immune response (GO:0002891)3.00481667
72termination of RNA polymerase I transcription (GO:0006363)2.99550389
73necroptotic process (GO:0070266)2.98245426
74positive regulation of activated T cell proliferation (GO:0042104)2.95687135
75negative regulation of acute inflammatory response (GO:0002674)2.95328268
76positive regulation of JAK-STAT cascade (GO:0046427)2.94723442
77regulation of interleukin-10 production (GO:0032653)2.91812988
78regulation of vitamin metabolic process (GO:0030656)2.90426623
79negative regulation of T cell differentiation (GO:0045581)2.90332351
80mRNA cleavage (GO:0006379)2.89747363
81regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.88654058
82regulation of natural killer cell mediated immunity (GO:0002715)2.88654058
83positive regulation of production of molecular mediator of immune response (GO:0002702)2.87297685
84mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.85743162
85preassembly of GPI anchor in ER membrane (GO:0016254)2.83148606
86L-fucose catabolic process (GO:0042355)2.82936796
87fucose catabolic process (GO:0019317)2.82936796
88L-fucose metabolic process (GO:0042354)2.82936796
89piRNA metabolic process (GO:0034587)2.81786887
90cytokine production involved in immune response (GO:0002367)2.80416004
91response to mercury ion (GO:0046689)2.79764133
92regulation of interleukin-13 production (GO:0032656)2.78846386
93positive regulation of cell killing (GO:0031343)2.78523286
94RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.78277910
95tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.78277910
96regulation of tyrosine phosphorylation of STAT protein (GO:0042509)2.78119821
97regulation of cell killing (GO:0031341)2.75824711
98regulation of memory T cell differentiation (GO:0043380)2.73872992
99positive regulation of osteoclast differentiation (GO:0045672)2.71978354
100regulation of T-helper cell differentiation (GO:0045622)2.70865746

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.36436731
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.39335158
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.36906837
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.04181285
5ZNF274_21170338_ChIP-Seq_K562_Hela3.34484139
6NOTCH1_21737748_ChIP-Seq_TLL_Human3.28202082
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.25757449
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.15701997
9VDR_22108803_ChIP-Seq_LS180_Human2.76486765
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.71228512
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.65413921
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.57649727
13VDR_23849224_ChIP-Seq_CD4+_Human2.54118426
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.48369309
15ELK1_19687146_ChIP-ChIP_HELA_Human2.40014938
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.13534412
17TP53_22573176_ChIP-Seq_HFKS_Human2.11048309
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10545497
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.10052754
20FOXP3_21729870_ChIP-Seq_TREG_Human1.96757539
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.94013282
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.89681638
23PCGF2_27294783_Chip-Seq_NPCs_Mouse1.87350583
24YY1_21170310_ChIP-Seq_MESCs_Mouse1.86962800
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86211569
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.84025424
27IRF8_22096565_ChIP-ChIP_GC-B_Human1.80046380
28EWS_26573619_Chip-Seq_HEK293_Human1.78837532
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68724713
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61199138
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54810741
32MYC_18555785_ChIP-Seq_MESCs_Mouse1.53665932
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53620733
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.50691145
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49487941
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44382600
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41850895
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.40940776
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38535734
40EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37843316
41GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37147158
42TAF15_26573619_Chip-Seq_HEK293_Human1.37099800
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36740576
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36216003
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36192363
46DCP1A_22483619_ChIP-Seq_HELA_Human1.31797070
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29688403
48PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.29120442
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26583574
50PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.25948359
51GABP_19822575_ChIP-Seq_HepG2_Human1.23008846
52GATA3_26560356_Chip-Seq_TH2_Human1.22542215
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22458326
54TTF2_22483619_ChIP-Seq_HELA_Human1.20060852
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.19821319
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19753600
57ETV1_20927104_ChIP-Seq_GIST48_Human1.16835826
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16780034
59MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16608392
60MYC_19030024_ChIP-ChIP_MESCs_Mouse1.15052861
61RBPJ_21746931_ChIP-Seq_IB4_Human1.13240215
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12426132
63MYC_18940864_ChIP-ChIP_HL60_Human1.12327792
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09181290
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.08678965
66IRF1_19129219_ChIP-ChIP_H3396_Human1.08464551
67LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07941765
68KDM5A_27292631_Chip-Seq_BREAST_Human1.05691702
69ERG_20517297_ChIP-Seq_VCAP_Human1.05016738
70PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.04584090
71GATA6_21074721_ChIP-Seq_CACO-2_Human1.02485026
72HOXB7_26014856_ChIP-Seq_BT474_Human1.01099752
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00736291
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99670808
75PHF8_20622853_ChIP-Seq_HELA_Human0.98663392
76CBX2_22325352_ChIP-Seq_293T-Rex_Human0.98080342
77BCAT_22108803_ChIP-Seq_LS180_Human0.97819236
78GATA1_22025678_ChIP-Seq_K562_Human0.95526835
79NCOR_22424771_ChIP-Seq_293T_Human0.92087190
80NANOG_19829295_ChIP-Seq_ESCs_Human0.91988029
81SOX2_19829295_ChIP-Seq_ESCs_Human0.91988029
82AR_20517297_ChIP-Seq_VCAP_Human0.90078814
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89555454
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89236751
85CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88679132
86ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88098125
87NFYB_21822215_ChIP-Seq_K562_Human0.87493301
88POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87201385
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87101826
90FOXH1_21741376_ChIP-Seq_EPCs_Human0.86326775
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.85787352
92IGF1R_20145208_ChIP-Seq_DFB_Human0.85591421
93TCF4_22108803_ChIP-Seq_LS180_Human0.85318366
94CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.85120487
95GATA3_21878914_ChIP-Seq_MCF-7_Human0.84858080
96HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.84619758
97TDRD3_21172665_ChIP-Seq_MCF-7_Human0.84367257
98FUS_26573619_Chip-Seq_HEK293_Human0.84126062
99GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.83826143
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83103587

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.15886094
2MP0001873_stomach_inflammation5.25433953
3MP0001835_abnormal_antigen_presentation4.07391875
4MP0001348_abnormal_lacrimal_gland4.02554973
5MP0005671_abnormal_response_to3.29505361
6MP0002138_abnormal_hepatobiliary_system3.23533712
7MP0008875_abnormal_xenobiotic_pharmacok2.56977446
8MP0005645_abnormal_hypothalamus_physiol2.50948273
9MP0009333_abnormal_splenocyte_physiolog2.46010767
10MP0005387_immune_system_phenotype2.19639856
11MP0001790_abnormal_immune_system2.19639856
12MP0008877_abnormal_DNA_methylation2.18527938
13MP0002102_abnormal_ear_morphology2.14636699
14MP0008872_abnormal_physiological_respon2.12313642
15MP0000685_abnormal_immune_system2.11229014
16MP0005310_abnormal_salivary_gland2.03467712
17MP0000538_abnormal_urinary_bladder2.01673800
18MP0008057_abnormal_DNA_replication1.97934419
19MP0006082_CNS_inflammation1.92475889
20MP0004742_abnormal_vestibular_system1.70576207
21MP0000569_abnormal_digit_pigmentation1.63099806
22MP0003646_muscle_fatigue1.57691475
23MP0005167_abnormal_blood-brain_barrier1.56842749
24MP0003786_premature_aging1.55462552
25MP0001984_abnormal_olfaction1.53831447
26MP0004145_abnormal_muscle_electrophysio1.52303494
27MP0004381_abnormal_hair_follicle1.49569153
28MP0004043_abnormal_pH_regulation1.47351283
29MP0002234_abnormal_pharynx_morphology1.46692636
30MP0005000_abnormal_immune_tolerance1.43135568
31MP0001800_abnormal_humoral_immune1.33231104
32MP0009785_altered_susceptibility_to1.31578504
33MP0002166_altered_tumor_susceptibility1.28185454
34MP0008995_early_reproductive_senescence1.24852890
35MP0001968_abnormal_touch/_nociception1.20730620
36MP0004957_abnormal_blastocyst_morpholog1.19542248
37MP0008058_abnormal_DNA_repair1.18387679
38MP0003252_abnormal_bile_duct1.15192524
39MP0002405_respiratory_system_inflammati1.14521928
40MP0003718_maternal_effect1.10262588
41MP0005408_hypopigmentation1.09770169
42MP0004885_abnormal_endolymph1.08426580
43MP0001919_abnormal_reproductive_system1.08087131
44MP0005085_abnormal_gallbladder_physiolo1.07839466
45MP0005410_abnormal_fertilization1.04336351
46MP0002148_abnormal_hypersensitivity_rea1.02385975
47MP0002006_tumorigenesis0.99947079
48MP0001958_emphysema0.99903953
49MP0003186_abnormal_redox_activity0.99768129
50MP0003195_calcinosis0.98652864
51MP0006292_abnormal_olfactory_placode0.98284536
52MP0008789_abnormal_olfactory_epithelium0.95309481
53MP0003763_abnormal_thymus_physiology0.95082518
54MP0002736_abnormal_nociception_after0.94255767
55MP0010155_abnormal_intestine_physiology0.88878063
56MP0004142_abnormal_muscle_tone0.88308796
57MP0005075_abnormal_melanosome_morpholog0.86836981
58MP0002210_abnormal_sex_determination0.86094597
59MP0005332_abnormal_amino_acid0.85191893
60MP0001663_abnormal_digestive_system0.85117885
61MP0003950_abnormal_plasma_membrane0.84946348
62MP0000689_abnormal_spleen_morphology0.81644897
63MP0002254_reproductive_system_inflammat0.81257271
64MP0004782_abnormal_surfactant_physiolog0.78941852
65MP0001756_abnormal_urination0.77168992
66MP0006036_abnormal_mitochondrial_physio0.77017006
67MP0002420_abnormal_adaptive_immunity0.76913240
68MP0009745_abnormal_behavioral_response0.75544708
69MP0002723_abnormal_immune_serum0.73567780
70MP0001501_abnormal_sleep_pattern0.73362883
71MP0003045_fibrosis0.72758905
72MP0005389_reproductive_system_phenotype0.72688791
73MP0003693_abnormal_embryo_hatching0.72295305
74MP0001905_abnormal_dopamine_level0.71672835
75MP0002396_abnormal_hematopoietic_system0.71527592
76MP0001502_abnormal_circadian_rhythm0.71417763
77MP0002163_abnormal_gland_morphology0.70789664
78MP0005646_abnormal_pituitary_gland0.70435691
79MP0005025_abnormal_response_to0.70338661
80MP0002452_abnormal_antigen_presenting0.69659842
81MP0002277_abnormal_respiratory_mucosa0.69069948
82MP0008961_abnormal_basal_metabolism0.68872236
83MP0001929_abnormal_gametogenesis0.68705817
84MP0005084_abnormal_gallbladder_morpholo0.68132764
85MP0001881_abnormal_mammary_gland0.67894314
86MP0001819_abnormal_immune_cell0.67832435
87MP0010368_abnormal_lymphatic_system0.65332400
88MP0001661_extended_life_span0.64842129
89MP0001485_abnormal_pinna_reflex0.64614196
90MP0005083_abnormal_biliary_tract0.64317003
91MP0002722_abnormal_immune_system0.64014577
92MP0000703_abnormal_thymus_morphology0.62171981
93MP0001119_abnormal_female_reproductive0.62085661
94MP0002733_abnormal_thermal_nociception0.61860104
95MP0005501_abnormal_skin_physiology0.60361049
96MP0001845_abnormal_inflammatory_respons0.57192281
97MP0000653_abnormal_sex_gland0.56544494
98MP0005166_decreased_susceptibility_to0.56110689
99MP0005551_abnormal_eye_electrophysiolog0.55562001
100MP0001145_abnormal_male_reproductive0.52021124

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.56995566
2Tongue fasciculations (HP:0001308)5.22750517
3Abnormality of the pons (HP:0007361)5.00391180
4Muscle fibrillation (HP:0010546)4.81356848
5Chronic diarrhea (HP:0002028)4.57971620
6Severe muscular hypotonia (HP:0006829)4.05738675
7Hypoplasia of the pons (HP:0012110)3.99378122
8Fatigue (HP:0012378)3.95241756
9Generalized aminoaciduria (HP:0002909)3.56947604
10Large for gestational age (HP:0001520)3.42442496
11Nephronophthisis (HP:0000090)3.32137704
12Reduced antithrombin III activity (HP:0001976)3.19887609
133-Methylglutaconic aciduria (HP:0003535)3.18016128
14IgG deficiency (HP:0004315)3.14146914
15Renal cortical cysts (HP:0000803)3.12864967
16Increased IgM level (HP:0003496)3.01493028
17Abnormality of T cell physiology (HP:0011840)2.90010507
18Abnormal spermatogenesis (HP:0008669)2.89024048
19Type I transferrin isoform profile (HP:0003642)2.86860388
20Congenital stationary night blindness (HP:0007642)2.83431929
21Increased CSF lactate (HP:0002490)2.81320434
22IgA deficiency (HP:0002720)2.75789884
23Abnormality of alanine metabolism (HP:0010916)2.71284693
24Hyperalaninemia (HP:0003348)2.71284693
25Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.71284693
26Abnormality of the renal medulla (HP:0100957)2.68912715
27Abnormality of T cells (HP:0002843)2.65961822
28Azoospermia (HP:0000027)2.54939322
29Duplicated collecting system (HP:0000081)2.50699181
30Abnormality of the renal cortex (HP:0011035)2.47860806
31Cerebellar dysplasia (HP:0007033)2.47756950
32Increased serum lactate (HP:0002151)2.46729633
33Abnormality of the proximal phalanges of the hand (HP:0009834)2.39942975
34Hypomagnesemia (HP:0002917)2.34535353
35Mutism (HP:0002300)2.34408227
36Oral leukoplakia (HP:0002745)2.31005232
37Hypoplasia of the capital femoral epiphysis (HP:0003090)2.30785464
38Renal tubular acidosis (HP:0001947)2.30505376
39Acute necrotizing encephalopathy (HP:0006965)2.30346981
40Type II lissencephaly (HP:0007260)2.26838107
41Abnormality of the renal collecting system (HP:0004742)2.26784466
42Hepatic necrosis (HP:0002605)2.25355705
43Increased serum pyruvate (HP:0003542)2.22801869
44Abnormality of incisor morphology (HP:0011063)2.22043038
45Thyroiditis (HP:0100646)2.21712612
46Limb dystonia (HP:0002451)2.21289789
47CNS hypomyelination (HP:0003429)2.20023931
48Abnormality of vitamin B metabolism (HP:0004340)2.19546422
49Arthropathy (HP:0003040)2.17524367
50Proximal tubulopathy (HP:0000114)2.16476740
51Abnormal protein glycosylation (HP:0012346)2.13251734
52Abnormal glycosylation (HP:0012345)2.13251734
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.13251734
54Abnormal protein N-linked glycosylation (HP:0012347)2.13251734
55Severe combined immunodeficiency (HP:0004430)2.10445156
56Acute encephalopathy (HP:0006846)2.09136769
57Gonadotropin excess (HP:0000837)2.07643271
58Multiple enchondromatosis (HP:0005701)2.07320711
59Delayed CNS myelination (HP:0002188)2.06358799
60Decreased activity of mitochondrial respiratory chain (HP:0008972)2.06219674
61Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.06219674
62Medial flaring of the eyebrow (HP:0010747)2.05556808
63Abnormality of magnesium homeostasis (HP:0004921)2.05444443
64Abnormal number of erythroid precursors (HP:0012131)2.03683877
65Molar tooth sign on MRI (HP:0002419)2.03460877
66Abnormality of midbrain morphology (HP:0002418)2.03460877
67Homocystinuria (HP:0002156)2.02820564
68Abnormality of homocysteine metabolism (HP:0010919)2.02820564
69Lethargy (HP:0001254)2.00333856
70Pulmonary infiltrates (HP:0002113)1.96935821
71Mitochondrial inheritance (HP:0001427)1.96606059
72Lactic acidosis (HP:0003128)1.95063874
73Attenuation of retinal blood vessels (HP:0007843)1.93255006
74Abnormal cartilage morphology (HP:0002763)1.92439997
75Nausea (HP:0002018)1.91838054
76Adactyly (HP:0009776)1.90455586
77Abnormality of T cell number (HP:0011839)1.90381998
78Abnormal mitochondria in muscle tissue (HP:0008316)1.89014224
79Aplasia/hypoplasia of the uterus (HP:0008684)1.88667863
80Joint swelling (HP:0001386)1.87809664
81Pancreatic cysts (HP:0001737)1.85753027
82Carpal bone hypoplasia (HP:0001498)1.85432443
83Elevated erythrocyte sedimentation rate (HP:0003565)1.84866911
84Absent epiphyses (HP:0010577)1.81963774
85Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.81963774
86T lymphocytopenia (HP:0005403)1.81926795
87Renal tubular dysfunction (HP:0000124)1.81794261
88Cleft eyelid (HP:0000625)1.81420844
89Hypoglycemic coma (HP:0001325)1.81056859
90Dyskinesia (HP:0100660)1.80435855
91Abnormality of the ileum (HP:0001549)1.78760059
92Progressive macrocephaly (HP:0004481)1.77311446
93Pachygyria (HP:0001302)1.75037556
94Wrist flexion contracture (HP:0001239)1.75009241
95Meckel diverticulum (HP:0002245)1.74161778
96Abnormality of the intrinsic pathway (HP:0010989)1.73509889
97Fibular aplasia (HP:0002990)1.73371538
98Exertional dyspnea (HP:0002875)1.73341877
99Flat capital femoral epiphysis (HP:0003370)1.71500395
100Abnormality of the preputium (HP:0100587)1.70328159

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B4.34511429
2TSSK63.57653344
3EIF2AK13.37537129
4PKN23.26676742
5EIF2AK33.26538286
6PBK3.19632921
7NME12.84554500
8CLK12.81781064
9BCKDK2.75994079
10ACVR1B2.56874755
11FLT32.52235830
12TGFBR12.47254798
13ADRBK22.34222297
14CDK82.14900410
15TLK12.13706622
16TXK2.10146723
17PAK61.75622697
18MST41.74687232
19TAOK31.63852701
20NLK1.63043517
21ZAK1.59547048
22WNK41.53477374
23MKNK21.52298419
24GRK11.45279627
25SRPK11.42222411
26FRK1.34849750
27CCNB11.33409880
28VRK21.29319366
29VRK11.27273075
30FGFR11.21825009
31PHKG11.19122043
32PHKG21.19122043
33IKBKB1.14613789
34MAP2K61.14056652
35EIF2AK21.13745003
36PLK31.04890160
37PAK31.02883416
38ITK0.98404698
39IRAK10.92913166
40ADRBK10.88309894
41BMPR20.87889707
42MAP3K140.83756263
43BRD40.83658914
44CSNK1G10.82518169
45IRAK20.81764948
46MKNK10.80052220
47STK40.79959332
48MARK30.78972480
49TNK20.73753889
50STK390.71516122
51LIMK10.66639594
52JAK10.66048566
53TIE10.62969568
54BUB10.62472277
55DYRK20.61362697
56ERBB30.61150980
57PINK10.59009885
58KSR10.59008374
59GRK70.57071678
60AKT30.54060028
61NUAK10.52718066
62OXSR10.49961270
63JAK30.47725157
64NEK10.46595490
65WNK30.46466095
66PDK20.45767578
67CSNK1G30.44837894
68CHUK0.44698837
69IKBKE0.44478193
70CSNK1A1L0.42699342
71CDK70.41788826
72TRIM280.41557192
73RPS6KA50.41227582
74PLK10.41085383
75PRKCQ0.40840927
76TESK10.39834068
77MAPKAPK30.39749821
78PRKCI0.38923641
79DAPK20.37671617
80PTK60.36730711
81EPHA40.36559669
82RPS6KA10.35984387
83PIM10.34950165
84FER0.34058891
85INSRR0.31922834
86CDK90.30724529
87JAK20.30722621
88CHEK10.30335142
89MAPK130.29985920
90ATM0.28737158
91TYK20.27672212
92PIM20.27121521
93PKN10.26096244
94CSNK2A20.24042746
95RAF10.24007521
96PRKAA20.23363065
97WNK10.22990287
98CSNK1E0.22927309
99CSNK2A10.22055411
100CDK40.19443209

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.98844754
2Proteasome_Homo sapiens_hsa030503.94126048
3Allograft rejection_Homo sapiens_hsa053303.68824315
4Asthma_Homo sapiens_hsa053103.11659006
5Autoimmune thyroid disease_Homo sapiens_hsa053202.98939319
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.80923548
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.78652288
8RNA polymerase_Homo sapiens_hsa030202.68237830
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65865503
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.32844961
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18297296
12Protein export_Homo sapiens_hsa030602.17216114
13Oxidative phosphorylation_Homo sapiens_hsa001902.12256966
14Homologous recombination_Homo sapiens_hsa034401.98188699
15Propanoate metabolism_Homo sapiens_hsa006401.96434246
16Parkinsons disease_Homo sapiens_hsa050121.89964325
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75408588
18Primary immunodeficiency_Homo sapiens_hsa053401.74615318
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.61042737
20Butanoate metabolism_Homo sapiens_hsa006501.60875954
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.55287916
22RNA transport_Homo sapiens_hsa030131.41920204
23One carbon pool by folate_Homo sapiens_hsa006701.37303867
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30763289
25Systemic lupus erythematosus_Homo sapiens_hsa053221.29709912
26T cell receptor signaling pathway_Homo sapiens_hsa046601.28416754
27Pyrimidine metabolism_Homo sapiens_hsa002401.25651561
28Basal transcription factors_Homo sapiens_hsa030221.24190532
29RNA degradation_Homo sapiens_hsa030181.24140936
30Rheumatoid arthritis_Homo sapiens_hsa053231.19284808
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15334070
32Huntingtons disease_Homo sapiens_hsa050161.13939224
33Tryptophan metabolism_Homo sapiens_hsa003801.13929490
34Graft-versus-host disease_Homo sapiens_hsa053321.12036907
35Hematopoietic cell lineage_Homo sapiens_hsa046401.11596465
36Ribosome_Homo sapiens_hsa030101.08833033
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07198376
38Nitrogen metabolism_Homo sapiens_hsa009101.06505813
39Type I diabetes mellitus_Homo sapiens_hsa049401.06337242
40Sulfur relay system_Homo sapiens_hsa041221.01841098
41Linoleic acid metabolism_Homo sapiens_hsa005911.01118448
42Purine metabolism_Homo sapiens_hsa002301.00054613
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98337964
44Spliceosome_Homo sapiens_hsa030400.97559329
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.96838470
46Fanconi anemia pathway_Homo sapiens_hsa034600.92555413
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89777942
48Collecting duct acid secretion_Homo sapiens_hsa049660.83366225
49Caffeine metabolism_Homo sapiens_hsa002320.82696557
50Peroxisome_Homo sapiens_hsa041460.81786451
51Mismatch repair_Homo sapiens_hsa034300.81018022
52Mineral absorption_Homo sapiens_hsa049780.80055997
53Alzheimers disease_Homo sapiens_hsa050100.79849917
54Phototransduction_Homo sapiens_hsa047440.78610487
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75934188
56Fatty acid elongation_Homo sapiens_hsa000620.75288717
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.72318700
58beta-Alanine metabolism_Homo sapiens_hsa004100.71823960
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70626894
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69318040
61Measles_Homo sapiens_hsa051620.69097790
62Selenocompound metabolism_Homo sapiens_hsa004500.66551480
63Folate biosynthesis_Homo sapiens_hsa007900.64707558
64Fatty acid degradation_Homo sapiens_hsa000710.64037381
65Nucleotide excision repair_Homo sapiens_hsa034200.63732753
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.61507214
67Malaria_Homo sapiens_hsa051440.59920987
68Regulation of autophagy_Homo sapiens_hsa041400.59508983
69Taste transduction_Homo sapiens_hsa047420.58103172
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56135385
71Fatty acid metabolism_Homo sapiens_hsa012120.55908109
72DNA replication_Homo sapiens_hsa030300.55853002
73TGF-beta signaling pathway_Homo sapiens_hsa043500.55470398
74Antigen processing and presentation_Homo sapiens_hsa046120.53886238
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52864664
76Cardiac muscle contraction_Homo sapiens_hsa042600.50559546
77Olfactory transduction_Homo sapiens_hsa047400.48809796
78mRNA surveillance pathway_Homo sapiens_hsa030150.48218466
79Metabolic pathways_Homo sapiens_hsa011000.48130696
80Pyruvate metabolism_Homo sapiens_hsa006200.45771384
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42066259
82Base excision repair_Homo sapiens_hsa034100.39184923
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37539542
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36971987
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35490149
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35204757
87Legionellosis_Homo sapiens_hsa051340.32391132
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31555156
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31301459
90Retinol metabolism_Homo sapiens_hsa008300.29530777
91p53 signaling pathway_Homo sapiens_hsa041150.29096354
92Arginine and proline metabolism_Homo sapiens_hsa003300.29061310
93African trypanosomiasis_Homo sapiens_hsa051430.28508882
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27710440
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27147722
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26302228
97Non-homologous end-joining_Homo sapiens_hsa034500.24764702
98Fat digestion and absorption_Homo sapiens_hsa049750.21924610
99Epstein-Barr virus infection_Homo sapiens_hsa051690.21732891
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.21526074

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