RPL29P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)8.92165224
2regulation of isotype switching to IgG isotypes (GO:0048302)7.93818122
3regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)7.92554149
4regulation of chronic inflammatory response (GO:0002676)6.65503111
5regulation of regulatory T cell differentiation (GO:0045589)6.12697467
6regulation of immunoglobulin secretion (GO:0051023)5.63351178
7positive regulation of isotype switching (GO:0045830)5.56594841
8cellular response to ATP (GO:0071318)5.39338170
9positive regulation of DNA recombination (GO:0045911)5.14653289
10maturation of 5.8S rRNA (GO:0000460)4.74624859
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.69688771
12negative regulation of B cell apoptotic process (GO:0002903)4.57451048
13negative regulation of T-helper cell differentiation (GO:0045623)4.39773310
14negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.39773310
15DNA deamination (GO:0045006)4.22306887
16positive regulation of immunoglobulin mediated immune response (GO:0002891)4.16452074
17positive regulation of B cell mediated immunity (GO:0002714)4.16452074
18GTP biosynthetic process (GO:0006183)4.01722568
19positive regulation of interleukin-17 production (GO:0032740)3.99472267
20protein K63-linked deubiquitination (GO:0070536)3.89013900
21positive regulation of immunoglobulin production (GO:0002639)3.84261051
22regulation of podosome assembly (GO:0071801)3.82796223
23proteasome assembly (GO:0043248)3.81804262
24GDP-mannose metabolic process (GO:0019673)3.72309324
25negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.70887735
26regulation of isotype switching (GO:0045191)3.61335784
27positive regulation of activated T cell proliferation (GO:0042104)3.55167150
28negative regulation of acute inflammatory response (GO:0002674)3.54899926
29CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.54756552
30UTP biosynthetic process (GO:0006228)3.35363686
31negative regulation of nitric oxide biosynthetic process (GO:0045019)3.33323257
32regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.32976872
33regulation of mitotic spindle checkpoint (GO:1903504)3.32976872
34rRNA catabolic process (GO:0016075)3.31850507
35negative regulation of alpha-beta T cell differentiation (GO:0046639)3.30094852
36cilium or flagellum-dependent cell motility (GO:0001539)3.29011992
37regulation of cellular amino acid metabolic process (GO:0006521)3.28110016
38embryonic hemopoiesis (GO:0035162)3.26430971
39axoneme assembly (GO:0035082)3.26018539
40regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.23213821
41CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.23049014
42T-helper cell differentiation (GO:0042093)3.23049014
43DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.18862361
44signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.13595672
45signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.13595672
46signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.13595672
47positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.12419775
48establishment of protein localization to mitochondrial membrane (GO:0090151)3.09269973
49intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.07693143
50signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.07693143
51dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.06852892
52T cell differentiation involved in immune response (GO:0002292)3.06148463
53alpha-beta T cell differentiation involved in immune response (GO:0002293)3.06148463
54alpha-beta T cell activation involved in immune response (GO:0002287)3.06148463
55UTP metabolic process (GO:0046051)3.01287000
56termination of RNA polymerase III transcription (GO:0006386)2.98631564
57transcription elongation from RNA polymerase III promoter (GO:0006385)2.98631564
58negative regulation of synaptic transmission, GABAergic (GO:0032229)2.98510064
59positive regulation of prostaglandin secretion (GO:0032308)2.98487398
60positive regulation of humoral immune response (GO:0002922)2.98252235
61signal peptide processing (GO:0006465)2.98004687
62regulation of immunoglobulin mediated immune response (GO:0002889)2.97605798
63signal transduction involved in DNA damage checkpoint (GO:0072422)2.94955409
64signal transduction involved in DNA integrity checkpoint (GO:0072401)2.94955409
65regulation of B cell apoptotic process (GO:0002902)2.94168321
66cilium movement (GO:0003341)2.93613030
67positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)2.91829063
68signal transduction involved in cell cycle checkpoint (GO:0072395)2.90255692
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.88091765
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.87969294
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.87969294
72regulation of B cell mediated immunity (GO:0002712)2.86188479
73regulation of immunoglobulin production (GO:0002637)2.85647483
74positive regulation of B cell proliferation (GO:0030890)2.85380331
75mannosylation (GO:0097502)2.84567734
76water-soluble vitamin biosynthetic process (GO:0042364)2.83742410
77retinal cone cell development (GO:0046549)2.82895597
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.81619937
79positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.81281606
80CTP biosynthetic process (GO:0006241)2.81021760
81CTP metabolic process (GO:0046036)2.81021760
82base-excision repair, AP site formation (GO:0006285)2.80064404
83RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.79419091
84rRNA modification (GO:0000154)2.78675248
85respiratory chain complex IV assembly (GO:0008535)2.78531923
86maturation of SSU-rRNA (GO:0030490)2.76618240
87regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.75980236
88chaperone-mediated protein transport (GO:0072321)2.73602348
89epithelial cilium movement (GO:0003351)2.73311997
90DNA excision (GO:0044349)2.73193504
91nucleotide-excision repair, DNA damage removal (GO:0000718)2.73193504
92intracellular protein transmembrane import (GO:0044743)2.72342375
93regulation of proton transport (GO:0010155)2.71303969
94exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.71027897
95guanosine-containing compound biosynthetic process (GO:1901070)2.70850542
96positive regulation of JAK-STAT cascade (GO:0046427)2.70132604
97positive regulation of lymphocyte mediated immunity (GO:0002708)2.67790106
98UDP-N-acetylglucosamine metabolic process (GO:0006047)2.65665153
99nucleoside diphosphate phosphorylation (GO:0006165)2.64176979
100positive regulation of fatty acid transport (GO:2000193)2.64065239

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.91396162
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.27824509
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.09553326
4ELF1_17652178_ChIP-ChIP_JURKAT_Human4.09537585
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.53141388
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.15373520
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.12539917
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.01575656
9VDR_23849224_ChIP-Seq_CD4+_Human2.72474138
10ZNF274_21170338_ChIP-Seq_K562_Hela2.63915792
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.61021687
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.54854227
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.50294574
14SRF_21415370_ChIP-Seq_HL-1_Mouse2.33877748
15FOXP3_21729870_ChIP-Seq_TREG_Human2.32548125
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.13563642
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09699003
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06137992
19NOTCH1_21737748_ChIP-Seq_TLL_Human1.99193207
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95394445
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86531804
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.85968764
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.84345715
24EWS_26573619_Chip-Seq_HEK293_Human1.80051213
25VDR_22108803_ChIP-Seq_LS180_Human1.79881191
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.72463918
27DCP1A_22483619_ChIP-Seq_HELA_Human1.69975450
28CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.68504076
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.67159332
30TAF15_26573619_Chip-Seq_HEK293_Human1.66876791
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.64173220
32MYC_18940864_ChIP-ChIP_HL60_Human1.60479880
33ELK1_19687146_ChIP-ChIP_HELA_Human1.56841249
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55430095
35GATA3_26560356_Chip-Seq_TH2_Human1.55143816
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.53729618
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46274972
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41654691
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41459300
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34067064
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.33611745
42TP53_22573176_ChIP-Seq_HFKS_Human1.33238691
43IGF1R_20145208_ChIP-Seq_DFB_Human1.33155125
44GABP_19822575_ChIP-Seq_HepG2_Human1.27629350
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.27181576
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.26471112
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25831163
48ELK1_22589737_ChIP-Seq_MCF10A_Human1.25354035
49NANOG_19829295_ChIP-Seq_ESCs_Human1.23003895
50SOX2_19829295_ChIP-Seq_ESCs_Human1.23003895
51P300_19829295_ChIP-Seq_ESCs_Human1.22970986
52AR_20517297_ChIP-Seq_VCAP_Human1.22246317
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21363090
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19276183
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19164750
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18958920
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17839933
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16731622
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.16731622
60PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.16144632
61HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13918369
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.13254667
63EGR1_19032775_ChIP-ChIP_M12_Human1.12166820
64TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11121808
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09319386
66GATA6_21074721_ChIP-Seq_CACO-2_Human1.07479839
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.07044202
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06388263
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05770934
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04991830
71IRF8_21731497_ChIP-ChIP_J774_Mouse1.04875389
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04251991
73LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01838607
74TAF2_19829295_ChIP-Seq_ESCs_Human1.01108635
75ER_23166858_ChIP-Seq_MCF-7_Human1.00498103
76ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00402246
77CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.00330423
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98549117
79CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97960957
80SALL4_22934838_ChIP-ChIP_CD34+_Human0.97060690
81PHF8_20622853_ChIP-Seq_HELA_Human0.96650664
82EZH2_27294783_Chip-Seq_NPCs_Mouse0.96343608
83RBPJ_21746931_ChIP-Seq_IB4_Human0.96283920
84TTF2_22483619_ChIP-Seq_HELA_Human0.96120646
85NCOR_22424771_ChIP-Seq_293T_Human0.95783332
86ERA_21632823_ChIP-Seq_H3396_Human0.95652385
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95122527
88AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94576761
89GATA3_26560356_Chip-Seq_TH1_Human0.94177523
90GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94104249
91ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92521129
92NANOG_20526341_ChIP-Seq_ESCs_Human0.92340450
93AR_21572438_ChIP-Seq_LNCaP_Human0.91795617
94CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90669526
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90067032
96CBP_20019798_ChIP-Seq_JUKART_Human0.89866306
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89866306
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89273280
99TCF4_22108803_ChIP-Seq_LS180_Human0.88155537
100HOXB7_26014856_ChIP-Seq_BT474_Human0.87128100

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer5.26921710
2MP0008875_abnormal_xenobiotic_pharmacok3.73559305
3MP0001835_abnormal_antigen_presentation3.53130740
4MP0001873_stomach_inflammation3.16668317
5MP0008058_abnormal_DNA_repair2.62403641
6MP0003718_maternal_effect2.53478798
7MP0005671_abnormal_response_to2.42127369
8MP0000465_gastrointestinal_hemorrhage2.30743761
9MP0000685_abnormal_immune_system2.29350018
10MP0008872_abnormal_physiological_respon2.22866045
11MP0005451_abnormal_body_composition2.17417797
12MP0005408_hypopigmentation2.12578255
13MP0001348_abnormal_lacrimal_gland2.09053537
14MP0004147_increased_porphyrin_level2.04725058
15MP0006082_CNS_inflammation2.03718583
16MP0002166_altered_tumor_susceptibility2.03080771
17MP0002138_abnormal_hepatobiliary_system1.95742316
18MP0003786_premature_aging1.92780246
19MP0002006_tumorigenesis1.88553613
20MP0001853_heart_inflammation1.87708028
21MP0003693_abnormal_embryo_hatching1.87423596
22MP0001790_abnormal_immune_system1.87220468
23MP0005387_immune_system_phenotype1.87220468
24MP0004885_abnormal_endolymph1.84201786
25MP0005167_abnormal_blood-brain_barrier1.74215373
26MP0009785_altered_susceptibility_to1.70881399
27MP0002736_abnormal_nociception_after1.70062660
28MP0003806_abnormal_nucleotide_metabolis1.66566321
29MP0002148_abnormal_hypersensitivity_rea1.63900239
30MP0005253_abnormal_eye_physiology1.61204265
31MP0009333_abnormal_splenocyte_physiolog1.60468462
32MP0000604_amyloidosis1.59347001
33MP0001661_extended_life_span1.57022551
34MP0003866_abnormal_defecation1.55039388
35MP0009764_decreased_sensitivity_to1.49350847
36MP0001986_abnormal_taste_sensitivity1.46529728
37MP0001968_abnormal_touch/_nociception1.45814287
38MP0001800_abnormal_humoral_immune1.45682275
39MP0000372_irregular_coat_pigmentation1.45178617
40MP0002837_dystrophic_cardiac_calcinosis1.43333365
41MP0006036_abnormal_mitochondrial_physio1.41830143
42MP0005389_reproductive_system_phenotype1.41715007
43MP0010155_abnormal_intestine_physiology1.38147917
44MP0004142_abnormal_muscle_tone1.37658421
45MP0003646_muscle_fatigue1.35750334
46MP0001501_abnormal_sleep_pattern1.34882933
47MP0002102_abnormal_ear_morphology1.31965617
48MP0001919_abnormal_reproductive_system1.31357870
49MP0002405_respiratory_system_inflammati1.29706848
50MP0003186_abnormal_redox_activity1.28089030
51MP0003195_calcinosis1.24184840
52MP0005085_abnormal_gallbladder_physiolo1.21195127
53MP0002876_abnormal_thyroid_physiology1.19545849
54MP0005310_abnormal_salivary_gland1.17455236
55MP0003436_decreased_susceptibility_to1.16154199
56MP0005365_abnormal_bile_salt1.15852486
57MP0005000_abnormal_immune_tolerance1.10869851
58MP0005551_abnormal_eye_electrophysiolog1.10833792
59MP0002723_abnormal_immune_serum1.09872878
60MP0001666_abnormal_nutrient_absorption1.08599926
61MP0002160_abnormal_reproductive_system1.05816591
62MP0002277_abnormal_respiratory_mucosa1.04864711
63MP0001845_abnormal_inflammatory_respons1.03974008
64MP0003045_fibrosis1.02181267
65MP0005410_abnormal_fertilization1.02122660
66MP0005395_other_phenotype1.01725072
67MP0004145_abnormal_muscle_electrophysio0.98981417
68MP0002420_abnormal_adaptive_immunity0.98840792
69MP0005645_abnormal_hypothalamus_physiol0.98812581
70MP0003724_increased_susceptibility_to0.96734881
71MP0001663_abnormal_digestive_system0.96718910
72MP0006072_abnormal_retinal_apoptosis0.96516366
73MP0002452_abnormal_antigen_presenting0.96345039
74MP0001819_abnormal_immune_cell0.96124785
75MP0005636_abnormal_mineral_homeostasis0.95005294
76MP0004782_abnormal_surfactant_physiolog0.94781518
77MP0005025_abnormal_response_to0.92970024
78MP0006292_abnormal_olfactory_placode0.92761378
79MP0003763_abnormal_thymus_physiology0.92478035
80MP0005165_increased_susceptibility_to0.91072938
81MP0008469_abnormal_protein_level0.87938353
82MP0001764_abnormal_homeostasis0.84184915
83MP0002938_white_spotting0.83542121
84MP0008873_increased_physiological_sensi0.79983844
85MP0000689_abnormal_spleen_morphology0.79832211
86MP0003567_abnormal_fetal_cardiomyocyte0.76611254
87MP0005332_abnormal_amino_acid0.74635892
88MP0003011_delayed_dark_adaptation0.74170699
89MP0005166_decreased_susceptibility_to0.73742443
90MP0001905_abnormal_dopamine_level0.73036743
91MP0003252_abnormal_bile_duct0.69977661
92MP0005075_abnormal_melanosome_morpholog0.69907020
93MP0005319_abnormal_enzyme/_coenzyme0.69742928
94MP0002693_abnormal_pancreas_physiology0.67782147
95MP0001984_abnormal_olfaction0.66506598
96MP0001502_abnormal_circadian_rhythm0.66378515
97MP0001119_abnormal_female_reproductive0.66053106
98MP0008877_abnormal_DNA_methylation0.65749346
99MP0001881_abnormal_mammary_gland0.65362406
100MP0008007_abnormal_cellular_replicative0.64387881

Predicted human phenotypes

RankGene SetZ-score
1Reduced antithrombin III activity (HP:0001976)5.22105415
2Stomatitis (HP:0010280)4.66754327
3Abnormality of the renal cortex (HP:0011035)4.07637947
4Hypoproteinemia (HP:0003075)3.98591958
5Type I transferrin isoform profile (HP:0003642)3.94955505
6Bile duct proliferation (HP:0001408)3.68701295
7Abnormal biliary tract physiology (HP:0012439)3.68701295
8Abnormality of DNA repair (HP:0003254)3.49900547
9Pancreatic cysts (HP:0001737)3.40753023
10Adrenal hypoplasia (HP:0000835)3.39903130
11Absent rod-and cone-mediated responses on ERG (HP:0007688)3.35225120
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.34205685
13Absent/shortened dynein arms (HP:0200106)3.34205685
14Abnormality of the renal medulla (HP:0100957)3.14030968
15Congenital, generalized hypertrichosis (HP:0004540)3.08352898
16Renal cortical cysts (HP:0000803)3.02352556
17Constricted visual fields (HP:0001133)3.00649785
18Nephronophthisis (HP:0000090)2.98496528
19Methylmalonic acidemia (HP:0002912)2.89285813
20Abnormal protein glycosylation (HP:0012346)2.88839778
21Abnormal glycosylation (HP:0012345)2.88839778
22Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.88839778
23Abnormal protein N-linked glycosylation (HP:0012347)2.88839778
24Hypoplasia of the pons (HP:0012110)2.87160157
25Abnormality of the pons (HP:0007361)2.86538467
26Abnormal delayed hypersensitivity skin test (HP:0002963)2.85897122
27IgG deficiency (HP:0004315)2.77643408
28Reduced subcutaneous adipose tissue (HP:0003758)2.68836427
29Abnormal respiratory epithelium morphology (HP:0012253)2.68491437
30Abnormal respiratory motile cilium morphology (HP:0005938)2.68491437
31Methylmalonic aciduria (HP:0012120)2.65169584
32Pancreatic fibrosis (HP:0100732)2.64201663
33Chronic hepatic failure (HP:0100626)2.60565960
34Asplenia (HP:0001746)2.57012410
35Acute necrotizing encephalopathy (HP:0006965)2.49368031
36Abnormal ciliary motility (HP:0012262)2.48633801
37Abnormality of midbrain morphology (HP:0002418)2.46465817
38Molar tooth sign on MRI (HP:0002419)2.46465817
39Supernumerary spleens (HP:0009799)2.43471281
40Aplasia/Hypoplasia of the spleen (HP:0010451)2.43018571
41Insulin-resistant diabetes mellitus (HP:0000831)2.41836376
42Elevated erythrocyte sedimentation rate (HP:0003565)2.40247818
43Increased CSF lactate (HP:0002490)2.37807345
44Abnormal drinking behavior (HP:0030082)2.35820067
45Polydipsia (HP:0001959)2.35820067
46Abnormal mitochondria in muscle tissue (HP:0008316)2.34989273
47Entropion (HP:0000621)2.32874279
48Hepatocellular necrosis (HP:0001404)2.31775821
49Hepatic necrosis (HP:0002605)2.30547908
50Abnormal rod and cone electroretinograms (HP:0008323)2.28915431
51Tubular atrophy (HP:0000092)2.24990029
52Pancytopenia (HP:0001876)2.22218905
53Tubulointerstitial fibrosis (HP:0005576)2.21735676
54Acute encephalopathy (HP:0006846)2.19916805
553-Methylglutaconic aciduria (HP:0003535)2.19336247
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.18618109
57Polyuria (HP:0000103)2.17860244
58Abnormality of the anterior horn cell (HP:0006802)2.15510365
59Degeneration of anterior horn cells (HP:0002398)2.15510365
60Progressive macrocephaly (HP:0004481)2.13327651
61Meckel diverticulum (HP:0002245)2.13041298
62Absent thumb (HP:0009777)2.12738517
63Mitochondrial inheritance (HP:0001427)2.12468395
64Large for gestational age (HP:0001520)2.11909309
65Abnormality of the ileum (HP:0001549)2.10188837
66Brushfield spots (HP:0001088)2.02786518
67Progressive inability to walk (HP:0002505)2.02609387
68Abnormal respiratory motile cilium physiology (HP:0012261)2.01793011
69Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01472645
70CNS demyelination (HP:0007305)2.00306279
71Optic disc pallor (HP:0000543)1.99923753
72Increased serum lactate (HP:0002151)1.99744379
73Lipid accumulation in hepatocytes (HP:0006561)1.98256304
74Aplastic anemia (HP:0001915)1.96196727
75Duplicated collecting system (HP:0000081)1.94912054
76Microvesicular hepatic steatosis (HP:0001414)1.94637294
77Abnormality of the preputium (HP:0100587)1.92258693
78Cystic liver disease (HP:0006706)1.92250523
79Pendular nystagmus (HP:0012043)1.91099420
80Increased hepatocellular lipid droplets (HP:0006565)1.90461763
81Prolonged QT interval (HP:0001657)1.90408128
82Congenital stationary night blindness (HP:0007642)1.90074332
83Clubbing of toes (HP:0100760)1.89584036
84Abolished electroretinogram (ERG) (HP:0000550)1.89117996
85Hypokalemic alkalosis (HP:0001949)1.88783812
86Abnormality of the renal collecting system (HP:0004742)1.88378834
87Myopathic facies (HP:0002058)1.87453825
88Oligohydramnios (HP:0001562)1.87231374
89Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.86562098
90Decreased activity of mitochondrial respiratory chain (HP:0008972)1.86562098
91Exotropia (HP:0000577)1.86525872
92Decreased subcutaneous fat (HP:0001002)1.86245133
93Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85916136
94Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84446058
95Dicarboxylic aciduria (HP:0003215)1.84446058
96Keratoconus (HP:0000563)1.83145967
97Increased corneal curvature (HP:0100692)1.83145967
98True hermaphroditism (HP:0010459)1.82541084
99Tubulointerstitial abnormality (HP:0001969)1.81867448
100Type II lissencephaly (HP:0007260)1.80202517

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.99896746
2MAPKAPK32.93455775
3GRK12.86324820
4INSRR2.70300759
5TSSK62.65291233
6ZAK2.63059802
7NME12.54455203
8EIF2AK32.52709136
9TAOK32.45538046
10TLK12.31892771
11ADRBK22.15159092
12TRIM282.12990567
13VRK22.00821020
14PBK1.97528520
15MST41.94416470
16BCKDK1.94134082
17CSNK1A1L1.92465854
18TEC1.90901158
19CSNK1G31.84010831
20BMPR1B1.79882084
21NUAK11.75877254
22FRK1.75298563
23WNK41.72750337
24MAP3K131.70848345
25JAK31.68651986
26STK38L1.64935195
27GRK61.62938578
28NEK91.62830891
29TGFBR21.57618150
30CSNK1G21.55476513
31OXSR11.49579663
32WNK31.47018404
33STK391.45826505
34CSNK1G11.43943036
35IKBKB1.33936091
36PLK21.30057074
37TGFBR11.26575705
38NEK11.19989926
39DAPK11.18985055
40CAMKK21.18605629
41PLK31.17566909
42ITK1.17560424
43TXK1.05076841
44MAP3K141.03549952
45IKBKE1.02984487
46GRK51.01712036
47ACVR1B1.01076901
48EIF2AK10.99665964
49BUB10.97079511
50VRK10.88011657
51MAP4K20.86711546
52FES0.83767365
53SRPK10.82177550
54PRKCE0.75780319
55MAP4K10.71594266
56EIF2AK20.70081583
57MAP3K120.63957675
58PTK2B0.61749230
59ERBB30.61117698
60PAK40.57427030
61PASK0.55548353
62PIM10.54995995
63MAP2K60.54758242
64CDK80.53643078
65ATR0.51581215
66CCNB10.50342042
67ZAP700.49063392
68CSK0.48337607
69STK240.48112413
70LCK0.47565225
71STK30.47339152
72MATK0.46944745
73IGF1R0.46441916
74PHKG20.45281731
75PHKG10.45281731
76SYK0.44109958
77BTK0.41885174
78LYN0.39511268
79TAF10.37725390
80PIK3CA0.36705441
81PLK10.36520833
82ERBB20.36406658
83ATM0.36335706
84PRKCQ0.35184331
85PRKCI0.34977768
86WEE10.33321987
87CSNK2A20.33174342
88MAP3K40.33037308
89ADRBK10.30022667
90TNIK0.28380539
91STK40.27564799
92EGFR0.27222855
93CSNK1A10.26404533
94NME20.26131987
95CSNK1D0.25948330
96PAK30.25931212
97CSNK2A10.25912205
98DAPK20.25328998
99MAPK130.24424758
100MAPK100.22712792

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.37486965
2Asthma_Homo sapiens_hsa053103.78869686
3Allograft rejection_Homo sapiens_hsa053303.32486492
4Autoimmune thyroid disease_Homo sapiens_hsa053203.14627606
5Protein export_Homo sapiens_hsa030602.82810666
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.78203288
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.58676166
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.30079399
9RNA polymerase_Homo sapiens_hsa030202.17795987
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.16479190
11Type I diabetes mellitus_Homo sapiens_hsa049402.13580088
12Basal transcription factors_Homo sapiens_hsa030221.99744175
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.97111448
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.90542178
15Nucleotide excision repair_Homo sapiens_hsa034201.84624535
16Graft-versus-host disease_Homo sapiens_hsa053321.83623992
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.83013598
18Hematopoietic cell lineage_Homo sapiens_hsa046401.63732528
19Primary immunodeficiency_Homo sapiens_hsa053401.63689255
20Oxidative phosphorylation_Homo sapiens_hsa001901.61274964
21Fanconi anemia pathway_Homo sapiens_hsa034601.58103392
22RNA degradation_Homo sapiens_hsa030181.56144900
23Sulfur metabolism_Homo sapiens_hsa009201.55962950
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53021647
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49925629
26Selenocompound metabolism_Homo sapiens_hsa004501.46134461
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.37258079
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.36079894
29Regulation of autophagy_Homo sapiens_hsa041401.29386768
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.25382428
31Base excision repair_Homo sapiens_hsa034101.21816587
32Peroxisome_Homo sapiens_hsa041461.20397418
33Propanoate metabolism_Homo sapiens_hsa006401.16147464
34RNA transport_Homo sapiens_hsa030131.14939672
35T cell receptor signaling pathway_Homo sapiens_hsa046601.14098501
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13917189
37Pyrimidine metabolism_Homo sapiens_hsa002401.03473989
38One carbon pool by folate_Homo sapiens_hsa006701.02337848
39Linoleic acid metabolism_Homo sapiens_hsa005911.02243196
40N-Glycan biosynthesis_Homo sapiens_hsa005101.02085569
41Vitamin digestion and absorption_Homo sapiens_hsa049771.01985660
42Mismatch repair_Homo sapiens_hsa034301.01829824
43Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99088390
44Parkinsons disease_Homo sapiens_hsa050120.98719622
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96912332
46Histidine metabolism_Homo sapiens_hsa003400.95444767
47Rheumatoid arthritis_Homo sapiens_hsa053230.94121555
48Tryptophan metabolism_Homo sapiens_hsa003800.93069456
49beta-Alanine metabolism_Homo sapiens_hsa004100.92220615
50Homologous recombination_Homo sapiens_hsa034400.89993731
51Ribosome_Homo sapiens_hsa030100.86581555
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86240997
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81816613
54Huntingtons disease_Homo sapiens_hsa050160.81475328
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80040008
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74430522
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74343758
58Retinol metabolism_Homo sapiens_hsa008300.74285001
59Chemical carcinogenesis_Homo sapiens_hsa052040.73954395
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.72893690
61Phototransduction_Homo sapiens_hsa047440.71631046
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.71591181
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.71075154
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71004182
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70144696
66Nitrogen metabolism_Homo sapiens_hsa009100.69527917
67Arginine and proline metabolism_Homo sapiens_hsa003300.69455723
68Antigen processing and presentation_Homo sapiens_hsa046120.68320568
69Spliceosome_Homo sapiens_hsa030400.67298309
70Measles_Homo sapiens_hsa051620.66256556
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65616959
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64749962
73Purine metabolism_Homo sapiens_hsa002300.63476116
74Fructose and mannose metabolism_Homo sapiens_hsa000510.63295746
75Alzheimers disease_Homo sapiens_hsa050100.61877969
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59708188
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58600090
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57293169
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54764879
80Ether lipid metabolism_Homo sapiens_hsa005650.54725535
81Arachidonic acid metabolism_Homo sapiens_hsa005900.51890604
82Metabolic pathways_Homo sapiens_hsa011000.51767309
83ABC transporters_Homo sapiens_hsa020100.51552738
84Vitamin B6 metabolism_Homo sapiens_hsa007500.50623309
85DNA replication_Homo sapiens_hsa030300.46854808
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46428272
87Circadian rhythm_Homo sapiens_hsa047100.42640158
88Glutathione metabolism_Homo sapiens_hsa004800.40181871
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39897141
90Apoptosis_Homo sapiens_hsa042100.39496783
91Folate biosynthesis_Homo sapiens_hsa007900.38246398
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37951749
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37428639
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.36972669
95Collecting duct acid secretion_Homo sapiens_hsa049660.34974587
96Pyruvate metabolism_Homo sapiens_hsa006200.34946477
97Epstein-Barr virus infection_Homo sapiens_hsa051690.34236724
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31191001
99Tyrosine metabolism_Homo sapiens_hsa003500.30608161
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28257462

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