

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 8.92165224 |
| 2 | regulation of isotype switching to IgG isotypes (GO:0048302) | 7.93818122 |
| 3 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 7.92554149 |
| 4 | regulation of chronic inflammatory response (GO:0002676) | 6.65503111 |
| 5 | regulation of regulatory T cell differentiation (GO:0045589) | 6.12697467 |
| 6 | regulation of immunoglobulin secretion (GO:0051023) | 5.63351178 |
| 7 | positive regulation of isotype switching (GO:0045830) | 5.56594841 |
| 8 | cellular response to ATP (GO:0071318) | 5.39338170 |
| 9 | positive regulation of DNA recombination (GO:0045911) | 5.14653289 |
| 10 | maturation of 5.8S rRNA (GO:0000460) | 4.74624859 |
| 11 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 4.69688771 |
| 12 | negative regulation of B cell apoptotic process (GO:0002903) | 4.57451048 |
| 13 | negative regulation of T-helper cell differentiation (GO:0045623) | 4.39773310 |
| 14 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 4.39773310 |
| 15 | DNA deamination (GO:0045006) | 4.22306887 |
| 16 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 4.16452074 |
| 17 | positive regulation of B cell mediated immunity (GO:0002714) | 4.16452074 |
| 18 | GTP biosynthetic process (GO:0006183) | 4.01722568 |
| 19 | positive regulation of interleukin-17 production (GO:0032740) | 3.99472267 |
| 20 | protein K63-linked deubiquitination (GO:0070536) | 3.89013900 |
| 21 | positive regulation of immunoglobulin production (GO:0002639) | 3.84261051 |
| 22 | regulation of podosome assembly (GO:0071801) | 3.82796223 |
| 23 | proteasome assembly (GO:0043248) | 3.81804262 |
| 24 | GDP-mannose metabolic process (GO:0019673) | 3.72309324 |
| 25 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 3.70887735 |
| 26 | regulation of isotype switching (GO:0045191) | 3.61335784 |
| 27 | positive regulation of activated T cell proliferation (GO:0042104) | 3.55167150 |
| 28 | negative regulation of acute inflammatory response (GO:0002674) | 3.54899926 |
| 29 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 3.54756552 |
| 30 | UTP biosynthetic process (GO:0006228) | 3.35363686 |
| 31 | negative regulation of nitric oxide biosynthetic process (GO:0045019) | 3.33323257 |
| 32 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.32976872 |
| 33 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.32976872 |
| 34 | rRNA catabolic process (GO:0016075) | 3.31850507 |
| 35 | negative regulation of alpha-beta T cell differentiation (GO:0046639) | 3.30094852 |
| 36 | cilium or flagellum-dependent cell motility (GO:0001539) | 3.29011992 |
| 37 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.28110016 |
| 38 | embryonic hemopoiesis (GO:0035162) | 3.26430971 |
| 39 | axoneme assembly (GO:0035082) | 3.26018539 |
| 40 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.23213821 |
| 41 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 3.23049014 |
| 42 | T-helper cell differentiation (GO:0042093) | 3.23049014 |
| 43 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.18862361 |
| 44 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.13595672 |
| 45 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.13595672 |
| 46 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.13595672 |
| 47 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 3.12419775 |
| 48 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.09269973 |
| 49 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.07693143 |
| 50 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.07693143 |
| 51 | dolichol-linked oligosaccharide biosynthetic process (GO:0006488) | 3.06852892 |
| 52 | T cell differentiation involved in immune response (GO:0002292) | 3.06148463 |
| 53 | alpha-beta T cell differentiation involved in immune response (GO:0002293) | 3.06148463 |
| 54 | alpha-beta T cell activation involved in immune response (GO:0002287) | 3.06148463 |
| 55 | UTP metabolic process (GO:0046051) | 3.01287000 |
| 56 | termination of RNA polymerase III transcription (GO:0006386) | 2.98631564 |
| 57 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.98631564 |
| 58 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 2.98510064 |
| 59 | positive regulation of prostaglandin secretion (GO:0032308) | 2.98487398 |
| 60 | positive regulation of humoral immune response (GO:0002922) | 2.98252235 |
| 61 | signal peptide processing (GO:0006465) | 2.98004687 |
| 62 | regulation of immunoglobulin mediated immune response (GO:0002889) | 2.97605798 |
| 63 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.94955409 |
| 64 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.94955409 |
| 65 | regulation of B cell apoptotic process (GO:0002902) | 2.94168321 |
| 66 | cilium movement (GO:0003341) | 2.93613030 |
| 67 | positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531) | 2.91829063 |
| 68 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.90255692 |
| 69 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.88091765 |
| 70 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.87969294 |
| 71 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.87969294 |
| 72 | regulation of B cell mediated immunity (GO:0002712) | 2.86188479 |
| 73 | regulation of immunoglobulin production (GO:0002637) | 2.85647483 |
| 74 | positive regulation of B cell proliferation (GO:0030890) | 2.85380331 |
| 75 | mannosylation (GO:0097502) | 2.84567734 |
| 76 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.83742410 |
| 77 | retinal cone cell development (GO:0046549) | 2.82895597 |
| 78 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.81619937 |
| 79 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.81281606 |
| 80 | CTP biosynthetic process (GO:0006241) | 2.81021760 |
| 81 | CTP metabolic process (GO:0046036) | 2.81021760 |
| 82 | base-excision repair, AP site formation (GO:0006285) | 2.80064404 |
| 83 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.79419091 |
| 84 | rRNA modification (GO:0000154) | 2.78675248 |
| 85 | respiratory chain complex IV assembly (GO:0008535) | 2.78531923 |
| 86 | maturation of SSU-rRNA (GO:0030490) | 2.76618240 |
| 87 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 2.75980236 |
| 88 | chaperone-mediated protein transport (GO:0072321) | 2.73602348 |
| 89 | epithelial cilium movement (GO:0003351) | 2.73311997 |
| 90 | DNA excision (GO:0044349) | 2.73193504 |
| 91 | nucleotide-excision repair, DNA damage removal (GO:0000718) | 2.73193504 |
| 92 | intracellular protein transmembrane import (GO:0044743) | 2.72342375 |
| 93 | regulation of proton transport (GO:0010155) | 2.71303969 |
| 94 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.71027897 |
| 95 | guanosine-containing compound biosynthetic process (GO:1901070) | 2.70850542 |
| 96 | positive regulation of JAK-STAT cascade (GO:0046427) | 2.70132604 |
| 97 | positive regulation of lymphocyte mediated immunity (GO:0002708) | 2.67790106 |
| 98 | UDP-N-acetylglucosamine metabolic process (GO:0006047) | 2.65665153 |
| 99 | nucleoside diphosphate phosphorylation (GO:0006165) | 2.64176979 |
| 100 | positive regulation of fatty acid transport (GO:2000193) | 2.64065239 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.91396162 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.27824509 |
| 3 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.09553326 |
| 4 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 4.09537585 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.53141388 |
| 6 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.15373520 |
| 7 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 3.12539917 |
| 8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.01575656 |
| 9 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.72474138 |
| 10 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.63915792 |
| 11 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.61021687 |
| 12 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.54854227 |
| 13 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.50294574 |
| 14 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.33877748 |
| 15 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.32548125 |
| 16 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.13563642 |
| 17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.09699003 |
| 18 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.06137992 |
| 19 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.99193207 |
| 20 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.95394445 |
| 21 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.86531804 |
| 22 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.85968764 |
| 23 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.84345715 |
| 24 | EWS_26573619_Chip-Seq_HEK293_Human | 1.80051213 |
| 25 | VDR_22108803_ChIP-Seq_LS180_Human | 1.79881191 |
| 26 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.72463918 |
| 27 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.69975450 |
| 28 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.68504076 |
| 29 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.67159332 |
| 30 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.66876791 |
| 31 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.64173220 |
| 32 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.60479880 |
| 33 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.56841249 |
| 34 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.55430095 |
| 35 | GATA3_26560356_Chip-Seq_TH2_Human | 1.55143816 |
| 36 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.53729618 |
| 37 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.46274972 |
| 38 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.41654691 |
| 39 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.41459300 |
| 40 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.34067064 |
| 41 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.33611745 |
| 42 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.33238691 |
| 43 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.33155125 |
| 44 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.27629350 |
| 45 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.27181576 |
| 46 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.26471112 |
| 47 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.25831163 |
| 48 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.25354035 |
| 49 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.23003895 |
| 50 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.23003895 |
| 51 | P300_19829295_ChIP-Seq_ESCs_Human | 1.22970986 |
| 52 | AR_20517297_ChIP-Seq_VCAP_Human | 1.22246317 |
| 53 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.21363090 |
| 54 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.19276183 |
| 55 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.19164750 |
| 56 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.18958920 |
| 57 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.17839933 |
| 58 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.16731622 |
| 59 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.16731622 |
| 60 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.16144632 |
| 61 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.13918369 |
| 62 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.13254667 |
| 63 | EGR1_19032775_ChIP-ChIP_M12_Human | 1.12166820 |
| 64 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.11121808 |
| 65 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.09319386 |
| 66 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 1.07479839 |
| 67 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.07044202 |
| 68 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.06388263 |
| 69 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.05770934 |
| 70 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.04991830 |
| 71 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.04875389 |
| 72 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.04251991 |
| 73 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.01838607 |
| 74 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.01108635 |
| 75 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.00498103 |
| 76 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.00402246 |
| 77 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 1.00330423 |
| 78 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.98549117 |
| 79 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.97960957 |
| 80 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.97060690 |
| 81 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.96650664 |
| 82 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.96343608 |
| 83 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.96283920 |
| 84 | TTF2_22483619_ChIP-Seq_HELA_Human | 0.96120646 |
| 85 | NCOR_22424771_ChIP-Seq_293T_Human | 0.95783332 |
| 86 | ERA_21632823_ChIP-Seq_H3396_Human | 0.95652385 |
| 87 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.95122527 |
| 88 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.94576761 |
| 89 | GATA3_26560356_Chip-Seq_TH1_Human | 0.94177523 |
| 90 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.94104249 |
| 91 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.92521129 |
| 92 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.92340450 |
| 93 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.91795617 |
| 94 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.90669526 |
| 95 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.90067032 |
| 96 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.89866306 |
| 97 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.89866306 |
| 98 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.89273280 |
| 99 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.88155537 |
| 100 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.87128100 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003300_gastrointestinal_ulcer | 5.26921710 |
| 2 | MP0008875_abnormal_xenobiotic_pharmacok | 3.73559305 |
| 3 | MP0001835_abnormal_antigen_presentation | 3.53130740 |
| 4 | MP0001873_stomach_inflammation | 3.16668317 |
| 5 | MP0008058_abnormal_DNA_repair | 2.62403641 |
| 6 | MP0003718_maternal_effect | 2.53478798 |
| 7 | MP0005671_abnormal_response_to | 2.42127369 |
| 8 | MP0000465_gastrointestinal_hemorrhage | 2.30743761 |
| 9 | MP0000685_abnormal_immune_system | 2.29350018 |
| 10 | MP0008872_abnormal_physiological_respon | 2.22866045 |
| 11 | MP0005451_abnormal_body_composition | 2.17417797 |
| 12 | MP0005408_hypopigmentation | 2.12578255 |
| 13 | MP0001348_abnormal_lacrimal_gland | 2.09053537 |
| 14 | MP0004147_increased_porphyrin_level | 2.04725058 |
| 15 | MP0006082_CNS_inflammation | 2.03718583 |
| 16 | MP0002166_altered_tumor_susceptibility | 2.03080771 |
| 17 | MP0002138_abnormal_hepatobiliary_system | 1.95742316 |
| 18 | MP0003786_premature_aging | 1.92780246 |
| 19 | MP0002006_tumorigenesis | 1.88553613 |
| 20 | MP0001853_heart_inflammation | 1.87708028 |
| 21 | MP0003693_abnormal_embryo_hatching | 1.87423596 |
| 22 | MP0001790_abnormal_immune_system | 1.87220468 |
| 23 | MP0005387_immune_system_phenotype | 1.87220468 |
| 24 | MP0004885_abnormal_endolymph | 1.84201786 |
| 25 | MP0005167_abnormal_blood-brain_barrier | 1.74215373 |
| 26 | MP0009785_altered_susceptibility_to | 1.70881399 |
| 27 | MP0002736_abnormal_nociception_after | 1.70062660 |
| 28 | MP0003806_abnormal_nucleotide_metabolis | 1.66566321 |
| 29 | MP0002148_abnormal_hypersensitivity_rea | 1.63900239 |
| 30 | MP0005253_abnormal_eye_physiology | 1.61204265 |
| 31 | MP0009333_abnormal_splenocyte_physiolog | 1.60468462 |
| 32 | MP0000604_amyloidosis | 1.59347001 |
| 33 | MP0001661_extended_life_span | 1.57022551 |
| 34 | MP0003866_abnormal_defecation | 1.55039388 |
| 35 | MP0009764_decreased_sensitivity_to | 1.49350847 |
| 36 | MP0001986_abnormal_taste_sensitivity | 1.46529728 |
| 37 | MP0001968_abnormal_touch/_nociception | 1.45814287 |
| 38 | MP0001800_abnormal_humoral_immune | 1.45682275 |
| 39 | MP0000372_irregular_coat_pigmentation | 1.45178617 |
| 40 | MP0002837_dystrophic_cardiac_calcinosis | 1.43333365 |
| 41 | MP0006036_abnormal_mitochondrial_physio | 1.41830143 |
| 42 | MP0005389_reproductive_system_phenotype | 1.41715007 |
| 43 | MP0010155_abnormal_intestine_physiology | 1.38147917 |
| 44 | MP0004142_abnormal_muscle_tone | 1.37658421 |
| 45 | MP0003646_muscle_fatigue | 1.35750334 |
| 46 | MP0001501_abnormal_sleep_pattern | 1.34882933 |
| 47 | MP0002102_abnormal_ear_morphology | 1.31965617 |
| 48 | MP0001919_abnormal_reproductive_system | 1.31357870 |
| 49 | MP0002405_respiratory_system_inflammati | 1.29706848 |
| 50 | MP0003186_abnormal_redox_activity | 1.28089030 |
| 51 | MP0003195_calcinosis | 1.24184840 |
| 52 | MP0005085_abnormal_gallbladder_physiolo | 1.21195127 |
| 53 | MP0002876_abnormal_thyroid_physiology | 1.19545849 |
| 54 | MP0005310_abnormal_salivary_gland | 1.17455236 |
| 55 | MP0003436_decreased_susceptibility_to | 1.16154199 |
| 56 | MP0005365_abnormal_bile_salt | 1.15852486 |
| 57 | MP0005000_abnormal_immune_tolerance | 1.10869851 |
| 58 | MP0005551_abnormal_eye_electrophysiolog | 1.10833792 |
| 59 | MP0002723_abnormal_immune_serum | 1.09872878 |
| 60 | MP0001666_abnormal_nutrient_absorption | 1.08599926 |
| 61 | MP0002160_abnormal_reproductive_system | 1.05816591 |
| 62 | MP0002277_abnormal_respiratory_mucosa | 1.04864711 |
| 63 | MP0001845_abnormal_inflammatory_respons | 1.03974008 |
| 64 | MP0003045_fibrosis | 1.02181267 |
| 65 | MP0005410_abnormal_fertilization | 1.02122660 |
| 66 | MP0005395_other_phenotype | 1.01725072 |
| 67 | MP0004145_abnormal_muscle_electrophysio | 0.98981417 |
| 68 | MP0002420_abnormal_adaptive_immunity | 0.98840792 |
| 69 | MP0005645_abnormal_hypothalamus_physiol | 0.98812581 |
| 70 | MP0003724_increased_susceptibility_to | 0.96734881 |
| 71 | MP0001663_abnormal_digestive_system | 0.96718910 |
| 72 | MP0006072_abnormal_retinal_apoptosis | 0.96516366 |
| 73 | MP0002452_abnormal_antigen_presenting | 0.96345039 |
| 74 | MP0001819_abnormal_immune_cell | 0.96124785 |
| 75 | MP0005636_abnormal_mineral_homeostasis | 0.95005294 |
| 76 | MP0004782_abnormal_surfactant_physiolog | 0.94781518 |
| 77 | MP0005025_abnormal_response_to | 0.92970024 |
| 78 | MP0006292_abnormal_olfactory_placode | 0.92761378 |
| 79 | MP0003763_abnormal_thymus_physiology | 0.92478035 |
| 80 | MP0005165_increased_susceptibility_to | 0.91072938 |
| 81 | MP0008469_abnormal_protein_level | 0.87938353 |
| 82 | MP0001764_abnormal_homeostasis | 0.84184915 |
| 83 | MP0002938_white_spotting | 0.83542121 |
| 84 | MP0008873_increased_physiological_sensi | 0.79983844 |
| 85 | MP0000689_abnormal_spleen_morphology | 0.79832211 |
| 86 | MP0003567_abnormal_fetal_cardiomyocyte | 0.76611254 |
| 87 | MP0005332_abnormal_amino_acid | 0.74635892 |
| 88 | MP0003011_delayed_dark_adaptation | 0.74170699 |
| 89 | MP0005166_decreased_susceptibility_to | 0.73742443 |
| 90 | MP0001905_abnormal_dopamine_level | 0.73036743 |
| 91 | MP0003252_abnormal_bile_duct | 0.69977661 |
| 92 | MP0005075_abnormal_melanosome_morpholog | 0.69907020 |
| 93 | MP0005319_abnormal_enzyme/_coenzyme | 0.69742928 |
| 94 | MP0002693_abnormal_pancreas_physiology | 0.67782147 |
| 95 | MP0001984_abnormal_olfaction | 0.66506598 |
| 96 | MP0001502_abnormal_circadian_rhythm | 0.66378515 |
| 97 | MP0001119_abnormal_female_reproductive | 0.66053106 |
| 98 | MP0008877_abnormal_DNA_methylation | 0.65749346 |
| 99 | MP0001881_abnormal_mammary_gland | 0.65362406 |
| 100 | MP0008007_abnormal_cellular_replicative | 0.64387881 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Reduced antithrombin III activity (HP:0001976) | 5.22105415 |
| 2 | Stomatitis (HP:0010280) | 4.66754327 |
| 3 | Abnormality of the renal cortex (HP:0011035) | 4.07637947 |
| 4 | Hypoproteinemia (HP:0003075) | 3.98591958 |
| 5 | Type I transferrin isoform profile (HP:0003642) | 3.94955505 |
| 6 | Bile duct proliferation (HP:0001408) | 3.68701295 |
| 7 | Abnormal biliary tract physiology (HP:0012439) | 3.68701295 |
| 8 | Abnormality of DNA repair (HP:0003254) | 3.49900547 |
| 9 | Pancreatic cysts (HP:0001737) | 3.40753023 |
| 10 | Adrenal hypoplasia (HP:0000835) | 3.39903130 |
| 11 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 3.35225120 |
| 12 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 3.34205685 |
| 13 | Absent/shortened dynein arms (HP:0200106) | 3.34205685 |
| 14 | Abnormality of the renal medulla (HP:0100957) | 3.14030968 |
| 15 | Congenital, generalized hypertrichosis (HP:0004540) | 3.08352898 |
| 16 | Renal cortical cysts (HP:0000803) | 3.02352556 |
| 17 | Constricted visual fields (HP:0001133) | 3.00649785 |
| 18 | Nephronophthisis (HP:0000090) | 2.98496528 |
| 19 | Methylmalonic acidemia (HP:0002912) | 2.89285813 |
| 20 | Abnormal protein glycosylation (HP:0012346) | 2.88839778 |
| 21 | Abnormal glycosylation (HP:0012345) | 2.88839778 |
| 22 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.88839778 |
| 23 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.88839778 |
| 24 | Hypoplasia of the pons (HP:0012110) | 2.87160157 |
| 25 | Abnormality of the pons (HP:0007361) | 2.86538467 |
| 26 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.85897122 |
| 27 | IgG deficiency (HP:0004315) | 2.77643408 |
| 28 | Reduced subcutaneous adipose tissue (HP:0003758) | 2.68836427 |
| 29 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.68491437 |
| 30 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.68491437 |
| 31 | Methylmalonic aciduria (HP:0012120) | 2.65169584 |
| 32 | Pancreatic fibrosis (HP:0100732) | 2.64201663 |
| 33 | Chronic hepatic failure (HP:0100626) | 2.60565960 |
| 34 | Asplenia (HP:0001746) | 2.57012410 |
| 35 | Acute necrotizing encephalopathy (HP:0006965) | 2.49368031 |
| 36 | Abnormal ciliary motility (HP:0012262) | 2.48633801 |
| 37 | Abnormality of midbrain morphology (HP:0002418) | 2.46465817 |
| 38 | Molar tooth sign on MRI (HP:0002419) | 2.46465817 |
| 39 | Supernumerary spleens (HP:0009799) | 2.43471281 |
| 40 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.43018571 |
| 41 | Insulin-resistant diabetes mellitus (HP:0000831) | 2.41836376 |
| 42 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.40247818 |
| 43 | Increased CSF lactate (HP:0002490) | 2.37807345 |
| 44 | Abnormal drinking behavior (HP:0030082) | 2.35820067 |
| 45 | Polydipsia (HP:0001959) | 2.35820067 |
| 46 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.34989273 |
| 47 | Entropion (HP:0000621) | 2.32874279 |
| 48 | Hepatocellular necrosis (HP:0001404) | 2.31775821 |
| 49 | Hepatic necrosis (HP:0002605) | 2.30547908 |
| 50 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.28915431 |
| 51 | Tubular atrophy (HP:0000092) | 2.24990029 |
| 52 | Pancytopenia (HP:0001876) | 2.22218905 |
| 53 | Tubulointerstitial fibrosis (HP:0005576) | 2.21735676 |
| 54 | Acute encephalopathy (HP:0006846) | 2.19916805 |
| 55 | 3-Methylglutaconic aciduria (HP:0003535) | 2.19336247 |
| 56 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.18618109 |
| 57 | Polyuria (HP:0000103) | 2.17860244 |
| 58 | Abnormality of the anterior horn cell (HP:0006802) | 2.15510365 |
| 59 | Degeneration of anterior horn cells (HP:0002398) | 2.15510365 |
| 60 | Progressive macrocephaly (HP:0004481) | 2.13327651 |
| 61 | Meckel diverticulum (HP:0002245) | 2.13041298 |
| 62 | Absent thumb (HP:0009777) | 2.12738517 |
| 63 | Mitochondrial inheritance (HP:0001427) | 2.12468395 |
| 64 | Large for gestational age (HP:0001520) | 2.11909309 |
| 65 | Abnormality of the ileum (HP:0001549) | 2.10188837 |
| 66 | Brushfield spots (HP:0001088) | 2.02786518 |
| 67 | Progressive inability to walk (HP:0002505) | 2.02609387 |
| 68 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.01793011 |
| 69 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.01472645 |
| 70 | CNS demyelination (HP:0007305) | 2.00306279 |
| 71 | Optic disc pallor (HP:0000543) | 1.99923753 |
| 72 | Increased serum lactate (HP:0002151) | 1.99744379 |
| 73 | Lipid accumulation in hepatocytes (HP:0006561) | 1.98256304 |
| 74 | Aplastic anemia (HP:0001915) | 1.96196727 |
| 75 | Duplicated collecting system (HP:0000081) | 1.94912054 |
| 76 | Microvesicular hepatic steatosis (HP:0001414) | 1.94637294 |
| 77 | Abnormality of the preputium (HP:0100587) | 1.92258693 |
| 78 | Cystic liver disease (HP:0006706) | 1.92250523 |
| 79 | Pendular nystagmus (HP:0012043) | 1.91099420 |
| 80 | Increased hepatocellular lipid droplets (HP:0006565) | 1.90461763 |
| 81 | Prolonged QT interval (HP:0001657) | 1.90408128 |
| 82 | Congenital stationary night blindness (HP:0007642) | 1.90074332 |
| 83 | Clubbing of toes (HP:0100760) | 1.89584036 |
| 84 | Abolished electroretinogram (ERG) (HP:0000550) | 1.89117996 |
| 85 | Hypokalemic alkalosis (HP:0001949) | 1.88783812 |
| 86 | Abnormality of the renal collecting system (HP:0004742) | 1.88378834 |
| 87 | Myopathic facies (HP:0002058) | 1.87453825 |
| 88 | Oligohydramnios (HP:0001562) | 1.87231374 |
| 89 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.86562098 |
| 90 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.86562098 |
| 91 | Exotropia (HP:0000577) | 1.86525872 |
| 92 | Decreased subcutaneous fat (HP:0001002) | 1.86245133 |
| 93 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.85916136 |
| 94 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.84446058 |
| 95 | Dicarboxylic aciduria (HP:0003215) | 1.84446058 |
| 96 | Keratoconus (HP:0000563) | 1.83145967 |
| 97 | Increased corneal curvature (HP:0100692) | 1.83145967 |
| 98 | True hermaphroditism (HP:0010459) | 1.82541084 |
| 99 | Tubulointerstitial abnormality (HP:0001969) | 1.81867448 |
| 100 | Type II lissencephaly (HP:0007260) | 1.80202517 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TIE1 | 4.99896746 |
| 2 | MAPKAPK3 | 2.93455775 |
| 3 | GRK1 | 2.86324820 |
| 4 | INSRR | 2.70300759 |
| 5 | TSSK6 | 2.65291233 |
| 6 | ZAK | 2.63059802 |
| 7 | NME1 | 2.54455203 |
| 8 | EIF2AK3 | 2.52709136 |
| 9 | TAOK3 | 2.45538046 |
| 10 | TLK1 | 2.31892771 |
| 11 | ADRBK2 | 2.15159092 |
| 12 | TRIM28 | 2.12990567 |
| 13 | VRK2 | 2.00821020 |
| 14 | PBK | 1.97528520 |
| 15 | MST4 | 1.94416470 |
| 16 | BCKDK | 1.94134082 |
| 17 | CSNK1A1L | 1.92465854 |
| 18 | TEC | 1.90901158 |
| 19 | CSNK1G3 | 1.84010831 |
| 20 | BMPR1B | 1.79882084 |
| 21 | NUAK1 | 1.75877254 |
| 22 | FRK | 1.75298563 |
| 23 | WNK4 | 1.72750337 |
| 24 | MAP3K13 | 1.70848345 |
| 25 | JAK3 | 1.68651986 |
| 26 | STK38L | 1.64935195 |
| 27 | GRK6 | 1.62938578 |
| 28 | NEK9 | 1.62830891 |
| 29 | TGFBR2 | 1.57618150 |
| 30 | CSNK1G2 | 1.55476513 |
| 31 | OXSR1 | 1.49579663 |
| 32 | WNK3 | 1.47018404 |
| 33 | STK39 | 1.45826505 |
| 34 | CSNK1G1 | 1.43943036 |
| 35 | IKBKB | 1.33936091 |
| 36 | PLK2 | 1.30057074 |
| 37 | TGFBR1 | 1.26575705 |
| 38 | NEK1 | 1.19989926 |
| 39 | DAPK1 | 1.18985055 |
| 40 | CAMKK2 | 1.18605629 |
| 41 | PLK3 | 1.17566909 |
| 42 | ITK | 1.17560424 |
| 43 | TXK | 1.05076841 |
| 44 | MAP3K14 | 1.03549952 |
| 45 | IKBKE | 1.02984487 |
| 46 | GRK5 | 1.01712036 |
| 47 | ACVR1B | 1.01076901 |
| 48 | EIF2AK1 | 0.99665964 |
| 49 | BUB1 | 0.97079511 |
| 50 | VRK1 | 0.88011657 |
| 51 | MAP4K2 | 0.86711546 |
| 52 | FES | 0.83767365 |
| 53 | SRPK1 | 0.82177550 |
| 54 | PRKCE | 0.75780319 |
| 55 | MAP4K1 | 0.71594266 |
| 56 | EIF2AK2 | 0.70081583 |
| 57 | MAP3K12 | 0.63957675 |
| 58 | PTK2B | 0.61749230 |
| 59 | ERBB3 | 0.61117698 |
| 60 | PAK4 | 0.57427030 |
| 61 | PASK | 0.55548353 |
| 62 | PIM1 | 0.54995995 |
| 63 | MAP2K6 | 0.54758242 |
| 64 | CDK8 | 0.53643078 |
| 65 | ATR | 0.51581215 |
| 66 | CCNB1 | 0.50342042 |
| 67 | ZAP70 | 0.49063392 |
| 68 | CSK | 0.48337607 |
| 69 | STK24 | 0.48112413 |
| 70 | LCK | 0.47565225 |
| 71 | STK3 | 0.47339152 |
| 72 | MATK | 0.46944745 |
| 73 | IGF1R | 0.46441916 |
| 74 | PHKG2 | 0.45281731 |
| 75 | PHKG1 | 0.45281731 |
| 76 | SYK | 0.44109958 |
| 77 | BTK | 0.41885174 |
| 78 | LYN | 0.39511268 |
| 79 | TAF1 | 0.37725390 |
| 80 | PIK3CA | 0.36705441 |
| 81 | PLK1 | 0.36520833 |
| 82 | ERBB2 | 0.36406658 |
| 83 | ATM | 0.36335706 |
| 84 | PRKCQ | 0.35184331 |
| 85 | PRKCI | 0.34977768 |
| 86 | WEE1 | 0.33321987 |
| 87 | CSNK2A2 | 0.33174342 |
| 88 | MAP3K4 | 0.33037308 |
| 89 | ADRBK1 | 0.30022667 |
| 90 | TNIK | 0.28380539 |
| 91 | STK4 | 0.27564799 |
| 92 | EGFR | 0.27222855 |
| 93 | CSNK1A1 | 0.26404533 |
| 94 | NME2 | 0.26131987 |
| 95 | CSNK1D | 0.25948330 |
| 96 | PAK3 | 0.25931212 |
| 97 | CSNK2A1 | 0.25912205 |
| 98 | DAPK2 | 0.25328998 |
| 99 | MAPK13 | 0.24424758 |
| 100 | MAPK10 | 0.22712792 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.37486965 |
| 2 | Asthma_Homo sapiens_hsa05310 | 3.78869686 |
| 3 | Allograft rejection_Homo sapiens_hsa05330 | 3.32486492 |
| 4 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 3.14627606 |
| 5 | Protein export_Homo sapiens_hsa03060 | 2.82810666 |
| 6 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.78203288 |
| 7 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.58676166 |
| 8 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.30079399 |
| 9 | RNA polymerase_Homo sapiens_hsa03020 | 2.17795987 |
| 10 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.16479190 |
| 11 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.13580088 |
| 12 | Basal transcription factors_Homo sapiens_hsa03022 | 1.99744175 |
| 13 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.97111448 |
| 14 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.90542178 |
| 15 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.84624535 |
| 16 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.83623992 |
| 17 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.83013598 |
| 18 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.63732528 |
| 19 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.63689255 |
| 20 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.61274964 |
| 21 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.58103392 |
| 22 | RNA degradation_Homo sapiens_hsa03018 | 1.56144900 |
| 23 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.55962950 |
| 24 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.53021647 |
| 25 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.49925629 |
| 26 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.46134461 |
| 27 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.37258079 |
| 28 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.36079894 |
| 29 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.29386768 |
| 30 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.25382428 |
| 31 | Base excision repair_Homo sapiens_hsa03410 | 1.21816587 |
| 32 | Peroxisome_Homo sapiens_hsa04146 | 1.20397418 |
| 33 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.16147464 |
| 34 | RNA transport_Homo sapiens_hsa03013 | 1.14939672 |
| 35 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.14098501 |
| 36 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.13917189 |
| 37 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.03473989 |
| 38 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.02337848 |
| 39 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.02243196 |
| 40 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.02085569 |
| 41 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.01985660 |
| 42 | Mismatch repair_Homo sapiens_hsa03430 | 1.01829824 |
| 43 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.99088390 |
| 44 | Parkinsons disease_Homo sapiens_hsa05012 | 0.98719622 |
| 45 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.96912332 |
| 46 | Histidine metabolism_Homo sapiens_hsa00340 | 0.95444767 |
| 47 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.94121555 |
| 48 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.93069456 |
| 49 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.92220615 |
| 50 | Homologous recombination_Homo sapiens_hsa03440 | 0.89993731 |
| 51 | Ribosome_Homo sapiens_hsa03010 | 0.86581555 |
| 52 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.86240997 |
| 53 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.81816613 |
| 54 | Huntingtons disease_Homo sapiens_hsa05016 | 0.81475328 |
| 55 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.80040008 |
| 56 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.74430522 |
| 57 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.74343758 |
| 58 | Retinol metabolism_Homo sapiens_hsa00830 | 0.74285001 |
| 59 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.73954395 |
| 60 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.72893690 |
| 61 | Phototransduction_Homo sapiens_hsa04744 | 0.71631046 |
| 62 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.71591181 |
| 63 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.71075154 |
| 64 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.71004182 |
| 65 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.70144696 |
| 66 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.69527917 |
| 67 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.69455723 |
| 68 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.68320568 |
| 69 | Spliceosome_Homo sapiens_hsa03040 | 0.67298309 |
| 70 | Measles_Homo sapiens_hsa05162 | 0.66256556 |
| 71 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.65616959 |
| 72 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.64749962 |
| 73 | Purine metabolism_Homo sapiens_hsa00230 | 0.63476116 |
| 74 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.63295746 |
| 75 | Alzheimers disease_Homo sapiens_hsa05010 | 0.61877969 |
| 76 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.59708188 |
| 77 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.58600090 |
| 78 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.57293169 |
| 79 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.54764879 |
| 80 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.54725535 |
| 81 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.51890604 |
| 82 | Metabolic pathways_Homo sapiens_hsa01100 | 0.51767309 |
| 83 | ABC transporters_Homo sapiens_hsa02010 | 0.51552738 |
| 84 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.50623309 |
| 85 | DNA replication_Homo sapiens_hsa03030 | 0.46854808 |
| 86 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.46428272 |
| 87 | Circadian rhythm_Homo sapiens_hsa04710 | 0.42640158 |
| 88 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.40181871 |
| 89 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.39897141 |
| 90 | Apoptosis_Homo sapiens_hsa04210 | 0.39496783 |
| 91 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.38246398 |
| 92 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.37951749 |
| 93 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.37428639 |
| 94 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.36972669 |
| 95 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.34974587 |
| 96 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.34946477 |
| 97 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.34236724 |
| 98 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.31191001 |
| 99 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.30608161 |
| 100 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.28257462 |

