ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.51837119
2	nucleotide transmembrane transport (GO:1901679)	5.85276110
3	negative regulation of protein oligomerization (GO:0032460)	5.63681370
4	cytidine catabolic process (GO:0006216)	5.12745103
5	cytidine deamination (GO:0009972)	5.12745103
6	cytidine metabolic process (GO:0046087)	5.12745103
7	maturation of 5.8S rRNA (GO:0000460)	4.88585967
8	T-helper 1 type immune response (GO:0042088)	4.48230942
9	protein-cofactor linkage (GO:0018065)	4.33165320
10	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.20115071
11	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.12654364
12	protein import into peroxisome matrix (GO:0016558)	3.86764626
13	ATP synthesis coupled proton transport (GO:0015986)	3.70680650
14	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.70680650
15	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.60096880
16	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.52900780
17	ribosomal small subunit assembly (GO:0000028)	3.51415867
18	response to interferon-beta (GO:0035456)	3.50881567
19	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.50427416
20	regulation of protein homooligomerization (GO:0032462)	3.38954112
21	nucleotide transport (GO:0006862)	3.37392901
22	microglial cell activation (GO:0001774)	3.29540817
23	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	3.27929452
24	nephron tubule formation (GO:0072079)	3.25213854
25	cytolysis (GO:0019835)	3.18506060
26	metallo-sulfur cluster assembly (GO:0031163)	3.16121593
27	iron-sulfur cluster assembly (GO:0016226)	3.16121593
28	negative regulation of telomere maintenance (GO:0032205)	3.15042752
29	behavioral response to nicotine (GO:0035095)	3.14167199
30	respiratory electron transport chain (GO:0022904)	3.13597759
31	electron transport chain (GO:0022900)	3.13485891
32	regulation of activation of Janus kinase activity (GO:0010533)	3.08927314
33	rRNA catabolic process (GO:0016075)	3.07790371
34	regulation of T cell mediated cytotoxicity (GO:0001914)	3.06092078
35	regulation of isotype switching to IgG isotypes (GO:0048302)	3.01961517
36	neuron fate determination (GO:0048664)	2.99493975
37	sequestering of actin monomers (GO:0042989)	2.96478046
38	nephron epithelium morphogenesis (GO:0072088)	2.94424599
39	nephron tubule morphogenesis (GO:0072078)	2.94424599
40	spliceosomal snRNP assembly (GO:0000387)	2.93448086
41	water-soluble vitamin biosynthetic process (GO:0042364)	2.92954580
42	viral transcription (GO:0019083)	2.92923300
43	macrophage chemotaxis (GO:0048246)	2.87441862
44	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.84239396
45	positive regulation of B cell differentiation (GO:0045579)	2.82860245
46	cellular response to interferon-beta (GO:0035458)	2.81356809
47	negative regulation of mast cell activation (GO:0033004)	2.80882087
48	intracellular protein transmembrane import (GO:0044743)	2.79794884
49	indolalkylamine metabolic process (GO:0006586)	2.79508068
50	protein localization to peroxisome (GO:0072662)	2.77772083
51	protein targeting to peroxisome (GO:0006625)	2.77772083
52	establishment of protein localization to peroxisome (GO:0072663)	2.77772083
53	cilium or flagellum-dependent cell motility (GO:0001539)	2.76875473
54	platelet dense granule organization (GO:0060155)	2.76395923
55	lipopolysaccharide biosynthetic process (GO:0009103)	2.76311965
56	positive regulation of interleukin-17 production (GO:0032740)	2.75837048
57	positive regulation of defense response to virus by host (GO:0002230)	2.75105083
58	protein complex biogenesis (GO:0070271)	2.72489740
59	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.70935208
60	ribosomal small subunit biogenesis (GO:0042274)	2.70275289
61	translational termination (GO:0006415)	2.69402630
62	sulfation (GO:0051923)	2.68627177
63	negative regulation of execution phase of apoptosis (GO:1900118)	2.68167015
64	cornea development in camera-type eye (GO:0061303)	2.65781092
65	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.62553090
66	positive thymic T cell selection (GO:0045059)	2.61671965
67	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.60818296
68	actin nucleation (GO:0045010)	2.60023042
69	regulation of respiratory gaseous exchange (GO:0043576)	2.58307170
70	positive regulation of isotype switching (GO:0045830)	2.55678850
71	translational elongation (GO:0006414)	2.55574657
72	ATP biosynthetic process (GO:0006754)	2.52258322
73	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.52067131
74	positive regulation of interleukin-8 secretion (GO:2000484)	2.52063680
75	regulation of B cell receptor signaling pathway (GO:0050855)	2.50612696
76	positive T cell selection (GO:0043368)	2.50509739
77	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	2.50064253
78	adaptation of signaling pathway (GO:0023058)	2.49179302
79	regulation of T cell receptor signaling pathway (GO:0050856)	2.48305181
80	cell proliferation in forebrain (GO:0021846)	2.46547826
81	response to xenobiotic stimulus (GO:0009410)	2.46423984
82	interferon-gamma secretion (GO:0072643)	2.45749728
83	histone H4-K12 acetylation (GO:0043983)	2.44076727
84	negative regulation of viral genome replication (GO:0045071)	2.43670525
85	mast cell degranulation (GO:0043303)	2.43051161
86	mast cell activation involved in immune response (GO:0002279)	2.43051161
87	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.41758897
88	DNA damage response, signal transduction resulting in transcription (GO:0042772)	2.41731875
89	primary amino compound metabolic process (GO:1901160)	2.41180623
90	lipopolysaccharide metabolic process (GO:0008653)	2.40373154
91	regulation of mitochondrial translation (GO:0070129)	2.39878049
92	peroxisomal transport (GO:0043574)	2.39712444
93	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.39397242
94	negative regulation of cell killing (GO:0031342)	2.39397242
95	positive regulation of T cell mediated immunity (GO:0002711)	2.39325862
96	glycerophospholipid catabolic process (GO:0046475)	2.36637102
97	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.35830628
98	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.35239761
99	cellular protein complex disassembly (GO:0043624)	2.34772918
100	serotonin metabolic process (GO:0042428)	2.34539434

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.14189046
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.12994656
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.38097506
4	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.98598332
5	VDR_22108803_ChIP-Seq_LS180_Human	2.87809741
6	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.85390588
7	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.80333774
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.75022346
9	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.51612426
10	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.49057859
11	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.47195131
12	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.37163582
13	IGF1R_20145208_ChIP-Seq_DFB_Human	1.99856593
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.82082573
15	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.80636251
16	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.80195498
17	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.79069313
18	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.72989849
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.71310477
20	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.70680509
21	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.70534275
22	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.70086840
23	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.69797132
24	RNF2_27304074_Chip-Seq_NSC_Mouse	1.63443725
25	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.59439502
26	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.58993862
27	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.58367498
28	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.57757454
29	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.57593298
30	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.54559429
31	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.52469693
32	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.51297032
33	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.51174757
34	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.49160880
35	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.48769585
36	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.48560273
37	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.48560273
38	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.47843524
39	NANOG_20526341_ChIP-Seq_ESCs_Human	1.46859262
40	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.46070148
41	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.44812956
42	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.44812956
43	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.44461196
44	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.43866466
45	ERA_21632823_ChIP-Seq_H3396_Human	1.42001115
46	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.41546365
47	MYC_19829295_ChIP-Seq_ESCs_Human	1.38975463
48	IRF1_19129219_ChIP-ChIP_H3396_Human	1.38432437
49	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.36685541
50	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.35701543
51	TAF2_19829295_ChIP-Seq_ESCs_Human	1.35497929
52	AR_21572438_ChIP-Seq_LNCaP_Human	1.33136352
53	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.32551173
54	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.31547053
55	HTT_18923047_ChIP-ChIP_STHdh_Human	1.29359428
56	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.26143341
57	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26135297
58	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.25454363
59	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.25310173
60	TP53_22573176_ChIP-Seq_HFKS_Human	1.24524670
61	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23531504
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23531504
63	P300_19829295_ChIP-Seq_ESCs_Human	1.23118369
64	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.22935757
65	AR_20517297_ChIP-Seq_VCAP_Human	1.22727073
66	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.20969978
67	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20622226
68	GBX2_23144817_ChIP-Seq_PC3_Human	1.18675440
69	BCL6_27268052_Chip-Seq_Bcells_Human	1.18370511
70	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.18308656
71	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.16517429
72	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.15299621
73	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.14719020
74	NCOR_22424771_ChIP-Seq_293T_Human	1.14539317
75	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.14148818
76	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.12328537
77	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08870336
78	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.07931639
79	P53_21459846_ChIP-Seq_SAOS-2_Human	1.07613336
80	E2F1_20622854_ChIP-Seq_HELA_Human	1.07522149
81	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.05052073
82	SA1_27219007_Chip-Seq_Bcells_Human	1.04350921
83	VDR_23849224_ChIP-Seq_CD4+_Human	1.03409063
84	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02947637
85	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00306116
86	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.99913045
87	RAC3_21632823_ChIP-Seq_H3396_Human	0.99763045
88	TAF15_26573619_Chip-Seq_HEK293_Human	0.99725880
89	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99422950
90	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99336509
91	REST_21632747_ChIP-Seq_MESCs_Mouse	0.98883147
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97421641
93	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.97140700
94	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.96416361
95	SMRT_27268052_Chip-Seq_Bcells_Human	0.95893219
96	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.94326472
97	CTCF_20526341_ChIP-Seq_ESCs_Human	0.94323770
98	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.93223666
99	GATA3_27048872_Chip-Seq_THYMUS_Human	0.90872645
100	ERG_20517297_ChIP-Seq_VCAP_Human	0.90105817

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002254_reproductive_system_inflammat	5.24337390
2	MP0006082_CNS_inflammation	4.50961957
3	MP0005671_abnormal_response_to	3.72661641
4	MP0001873_stomach_inflammation	3.49507525
5	MP0006292_abnormal_olfactory_placode	2.83569690
6	MP0002102_abnormal_ear_morphology	2.77208693
7	MP0002277_abnormal_respiratory_mucosa	2.54175648
8	MP0000372_irregular_coat_pigmentation	2.45477910
9	MP0002876_abnormal_thyroid_physiology	2.35835219
10	MP0008875_abnormal_xenobiotic_pharmacok	2.19975812
11	MP0005645_abnormal_hypothalamus_physiol	2.18532157
12	MP0000685_abnormal_immune_system	2.12574431
13	MP0009785_altered_susceptibility_to	2.09554261
14	MP0002822_catalepsy	2.08871408
15	MP0001905_abnormal_dopamine_level	2.08633032
16	MP0003011_delayed_dark_adaptation	2.06700971
17	MP0002132_abnormal_respiratory_system	2.02713743
18	MP0010386_abnormal_urinary_bladder	2.02411716
19	MP0005084_abnormal_gallbladder_morpholo	1.97687548
20	MP0005389_reproductive_system_phenotype	1.95751851
21	MP0002837_dystrophic_cardiac_calcinosis	1.86792187
22	MP0001919_abnormal_reproductive_system	1.85553078
23	MP0003195_calcinosis	1.72508852
24	MP0006072_abnormal_retinal_apoptosis	1.70405837
25	MP0002160_abnormal_reproductive_system	1.59777548
26	MP0003646_muscle_fatigue	1.54392881
27	MP0004147_increased_porphyrin_level	1.48951156
28	MP0003763_abnormal_thymus_physiology	1.47700158
29	MP0001348_abnormal_lacrimal_gland	1.44495512
30	MP0002138_abnormal_hepatobiliary_system	1.44222047
31	MP0005646_abnormal_pituitary_gland	1.43368380
32	MP0005025_abnormal_response_to	1.36458375
33	MP0000631_abnormal_neuroendocrine_gland	1.33949443
34	MP0009379_abnormal_foot_pigmentation	1.32172432
35	MP0003866_abnormal_defecation	1.26880244
36	MP0003880_abnormal_central_pattern	1.26231436
37	MP0005551_abnormal_eye_electrophysiolog	1.26169164
38	MP0003879_abnormal_hair_cell	1.14547445
39	MP0001663_abnormal_digestive_system	1.11457545
40	MP0001986_abnormal_taste_sensitivity	1.10791611
41	MP0002653_abnormal_ependyma_morphology	1.09524010
42	MP0005360_urolithiasis	1.07574086
43	MP0005000_abnormal_immune_tolerance	1.06576982
44	MP0002928_abnormal_bile_duct	1.05611662
45	MP0001346_abnormal_lacrimal_gland	1.05403630
46	MP0009333_abnormal_splenocyte_physiolog	1.05115753
47	MP0006276_abnormal_autonomic_nervous	1.05046949
48	MP0001800_abnormal_humoral_immune	1.04389044
49	MP0005166_decreased_susceptibility_to	1.03947820
50	MP0002148_abnormal_hypersensitivity_rea	1.02992544
51	MP0005423_abnormal_somatic_nervous	1.01979308
52	MP0004019_abnormal_vitamin_homeostasis	1.00858342
53	MP0001968_abnormal_touch/_nociception	1.00364183
54	MP0002723_abnormal_immune_serum	0.99806525
55	MP0005085_abnormal_gallbladder_physiolo	0.99523137
56	MP0004145_abnormal_muscle_electrophysio	0.99414564
57	MP0003938_abnormal_ear_development	0.98968604
58	MP0004142_abnormal_muscle_tone	0.98005705
59	MP0005387_immune_system_phenotype	0.96932448
60	MP0001790_abnormal_immune_system	0.96932448
61	MP0000049_abnormal_middle_ear	0.96354962
62	MP0003252_abnormal_bile_duct	0.95672905
63	MP0009745_abnormal_behavioral_response	0.94988887
64	MP0002693_abnormal_pancreas_physiology	0.94677128
65	MP0008872_abnormal_physiological_respon	0.94253747
66	MP0002163_abnormal_gland_morphology	0.94031774
67	MP0008877_abnormal_DNA_methylation	0.93266719
68	MP0005253_abnormal_eye_physiology	0.92249927
69	MP0005410_abnormal_fertilization	0.91885160
70	MP0002272_abnormal_nervous_system	0.91471086
71	MP0004885_abnormal_endolymph	0.89732087
72	MP0001835_abnormal_antigen_presentation	0.88080951
73	MP0001119_abnormal_female_reproductive	0.87757720
74	MP0002420_abnormal_adaptive_immunity	0.87158529
75	MP0002452_abnormal_antigen_presenting	0.86553863
76	MP0002638_abnormal_pupillary_reflex	0.86273801
77	MP0009046_muscle_twitch	0.85866986
78	MP0005377_hearing/vestibular/ear_phenot	0.85541711
79	MP0003878_abnormal_ear_physiology	0.85541711
80	MP0005647_abnormal_sex_gland	0.84171383
81	MP0001819_abnormal_immune_cell	0.81349176
82	MP0004133_heterotaxia	0.80920345
83	MP0002933_joint_inflammation	0.79957067
84	MP0002405_respiratory_system_inflammati	0.79745976
85	MP0003724_increased_susceptibility_to	0.78488014
86	MP0000026_abnormal_inner_ear	0.77663636
87	MP0001485_abnormal_pinna_reflex	0.74778225
88	MP0002095_abnormal_skin_pigmentation	0.73175952
89	MP0002736_abnormal_nociception_after	0.71478505
90	MP0003786_premature_aging	0.71226995
91	MP0003136_yellow_coat_color	0.70547596
92	MP0001764_abnormal_homeostasis	0.69647357
93	MP0005636_abnormal_mineral_homeostasis	0.69564439
94	MP0003950_abnormal_plasma_membrane	0.67537046
95	MP0005195_abnormal_posterior_eye	0.66931533
96	MP0002064_seizures	0.66013450
97	MP0003690_abnormal_glial_cell	0.65589603
98	MP0005503_abnormal_tendon_morphology	0.65023201
99	MP0008995_early_reproductive_senescence	0.64732389
100	MP0002572_abnormal_emotion/affect_behav	0.64647739

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Fibular aplasia (HP:0002990)	4.50985831
2	Aplastic anemia (HP:0001915)	3.57871765
3	Stomatitis (HP:0010280)	3.45444044
4	Abnormal finger flexion creases (HP:0006143)	3.35331102
5	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	3.11576619
6	Humeroradial synostosis (HP:0003041)	3.07630116
7	Synostosis involving the elbow (HP:0003938)	3.07630116
8	Hypothermia (HP:0002045)	3.05688754
9	Polydipsia (HP:0001959)	3.03357911
10	Abnormal drinking behavior (HP:0030082)	3.03357911
11	Delayed closure of the anterior fontanelle (HP:0001476)	2.96337926
12	Brushfield spots (HP:0001088)	2.91864874
13	Abnormality of B cell number (HP:0010975)	2.90401367
14	Tetany (HP:0001281)	2.87035296
15	Increased hepatocellular lipid droplets (HP:0006565)	2.86412949
16	Hypomagnesemia (HP:0002917)	2.83842013
17	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.83105210
18	Methylmalonic acidemia (HP:0002912)	2.72344061
19	Mitochondrial inheritance (HP:0001427)	2.70311305
20	Radial bowing (HP:0002986)	2.69784827
21	Autoimmune thrombocytopenia (HP:0001973)	2.68987716
22	Abnormality of the prostate (HP:0008775)	2.62441634
23	True hermaphroditism (HP:0010459)	2.60213478
24	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.59286827
25	Congenital stationary night blindness (HP:0007642)	2.58035374
26	Aplasia/hypoplasia of the uterus (HP:0008684)	2.56358757
27	Thyroid-stimulating hormone excess (HP:0002925)	2.55247479
28	Acute necrotizing encephalopathy (HP:0006965)	2.53831934
29	Increased intramyocellular lipid droplets (HP:0012240)	2.53131899
30	Lipid accumulation in hepatocytes (HP:0006561)	2.51670885
31	Abnormal number of erythroid precursors (HP:0012131)	2.51174340
32	Abnormality of magnesium homeostasis (HP:0004921)	2.45720869
33	Nasal polyposis (HP:0100582)	2.42981567
34	Abnormal mitochondria in muscle tissue (HP:0008316)	2.42760778
35	Increased CSF lactate (HP:0002490)	2.41547300
36	Constricted visual fields (HP:0001133)	2.39685692
37	Renal Fanconi syndrome (HP:0001994)	2.38964291
38	Elevated erythrocyte sedimentation rate (HP:0003565)	2.37491974
39	Keratoconus (HP:0000563)	2.36343876
40	Increased corneal curvature (HP:0100692)	2.36343876
41	Medial flaring of the eyebrow (HP:0010747)	2.35872541
42	Asplenia (HP:0001746)	2.33385193
43	Absent phalangeal crease (HP:0006109)	2.33017057
44	Methylmalonic aciduria (HP:0012120)	2.28454718
45	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.26149763
46	Pancreatic cysts (HP:0001737)	2.25716694
47	Chronic diarrhea (HP:0002028)	2.23512616
48	Abolished electroretinogram (ERG) (HP:0000550)	2.23421056
49	Exertional dyspnea (HP:0002875)	2.23201894
50	Flat occiput (HP:0005469)	2.22012170
51	Decreased central vision (HP:0007663)	2.21156869
52	Oral leukoplakia (HP:0002745)	2.19518126
53	Pendular nystagmus (HP:0012043)	2.18637696
54	Aplasia/Hypoplasia of the patella (HP:0006498)	2.16677871
55	Abnormality of male internal genitalia (HP:0000022)	2.16454081
56	Concave nail (HP:0001598)	2.16012288
57	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.15671372
58	Patellar aplasia (HP:0006443)	2.14575530
59	Polyuria (HP:0000103)	2.14146115
60	Split foot (HP:0001839)	2.11575774
61	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.10639131
62	Abnormal ciliary motility (HP:0012262)	2.09626502
63	Hypoproteinemia (HP:0003075)	2.07956206
64	Hypoplastic iliac wings (HP:0002866)	2.04877160
65	Abnormality of cells of the erythroid lineage (HP:0012130)	2.04469388
66	Cerebellar dysplasia (HP:0007033)	2.03699283
67	Acute encephalopathy (HP:0006846)	2.02081752
68	Increased muscle lipid content (HP:0009058)	2.01844416
69	Abnormality of T cell number (HP:0011839)	2.01529990
70	Adactyly (HP:0009776)	1.98975192
71	Abnormality of urine glucose concentration (HP:0011016)	1.98005033
72	Glycosuria (HP:0003076)	1.98005033
73	Respiratory distress (HP:0002098)	1.97424524
74	Abnormal rod and cone electroretinograms (HP:0008323)	1.96777340
75	Progressive macrocephaly (HP:0004481)	1.95461854
76	Morphological abnormality of the middle ear (HP:0008609)	1.94013722
77	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.93975485
78	Abnormal respiratory motile cilium physiology (HP:0012261)	1.93769999
79	Ureteral obstruction (HP:0006000)	1.92800439
80	Type II lissencephaly (HP:0007260)	1.92297849
81	Abnormality of the nasal mucosa (HP:0000433)	1.91812496
82	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.90596174
83	Abnormality of the pubic bones (HP:0003172)	1.90448824
84	Lymphopenia (HP:0001888)	1.89819949
85	Attenuation of retinal blood vessels (HP:0007843)	1.88859622
86	Hepatocellular necrosis (HP:0001404)	1.88501539
87	Abnormality of cells of the lymphoid lineage (HP:0012140)	1.87393057
88	Chronic mucocutaneous candidiasis (HP:0002728)	1.87063662
89	Recurrent cutaneous fungal infections (HP:0011370)	1.87063662
90	Decreased circulating renin level (HP:0003351)	1.86202386
91	Abnormality of vitamin B metabolism (HP:0004340)	1.83674588
92	Oligodactyly (hands) (HP:0001180)	1.82616982
93	Severe combined immunodeficiency (HP:0004430)	1.81057840
94	Macrocytic anemia (HP:0001972)	1.80501259
95	Abnormal urine output (HP:0012590)	1.79332376
96	IgG deficiency (HP:0004315)	1.77869403
97	Chronic bronchitis (HP:0004469)	1.76308651
98	Optic disc pallor (HP:0000543)	1.75774217
99	Abnormality of T cells (HP:0002843)	1.74528320
100	Abnormal respiratory epithelium morphology (HP:0012253)	1.74167720

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	4.33344949
2	MAP3K9	4.04282711
3	PASK	3.80250799
4	TXK	2.88965934
5	KDR	2.72171754
6	TESK2	2.44613947
7	VRK1	2.43629068
8	VRK2	2.37235212
9	ITK	2.35008249
10	TAF1	2.31967750
11	TLK1	2.23417066
12	TAOK3	2.13755116
13	MAP3K13	2.08973616
14	ADRBK2	2.02932145
15	MARK1	1.87577311
16	TSSK6	1.86978888
17	PKN1	1.85484454
18	NTRK2	1.83954861
19	MUSK	1.75444164
20	MAP4K2	1.71518837
21	ZAK	1.67891348
22	GRK1	1.65018604
23	MAP4K1	1.64815730
24	BCKDK	1.35486959
25	TEC	1.29609704
26	PNCK	1.24753625
27	FRK	1.22620331
28	CDK19	1.19957408
29	WNK3	1.13044331
30	SYK	1.11974121
31	IKBKB	1.10665098
32	RPS6KA5	1.10499673
33	BTK	1.04234333
34	CAMKK1	1.03277384
35	CSNK1G3	1.02725695
36	CSK	0.99623731
37	MAP2K7	0.98337585
38	WNK4	0.96902661
39	INSRR	0.96216819
40	MAPKAPK3	0.94390674
41	BMPR1B	0.94310993
42	CASK	0.93063743
43	MAP3K11	0.92749565
44	CSNK1G1	0.91310509
45	TYRO3	0.88719569
46	CSNK1G2	0.88185339
47	NUAK1	0.88132891
48	STK16	0.83944244
49	MAPK13	0.83151805
50	TNK2	0.80070004
51	AURKA	0.76730183
52	TBK1	0.75973784
53	IKBKE	0.74850619
54	PIK3CG	0.74718994
55	KIT	0.72179136
56	FGR	0.72082730
57	PRKCQ	0.71115966
58	OBSCN	0.69910879
59	MAPKAPK5	0.69483621
60	MAP3K14	0.67760217
61	PINK1	0.65824233
62	ABL2	0.65049000
63	MAP3K7	0.64960682
64	CHUK	0.61671852
65	DAPK3	0.58213187
66	LCK	0.55638888
67	ERBB3	0.54663712
68	MAP3K12	0.53234274
69	CSF1R	0.52173305
70	CSNK1A1L	0.52031097
71	WEE1	0.51877956
72	GRK7	0.50738525
73	ADRBK1	0.49627934
74	ABL1	0.48852316
75	CHEK2	0.45017241
76	LYN	0.44238797
77	GSK3A	0.43338407
78	FES	0.41849978
79	PRKACA	0.41601691
80	DYRK2	0.41120269
81	LIMK1	0.41015095
82	MAP3K5	0.40812893
83	RPS6KA6	0.40651204
84	TESK1	0.40571962
85	CDK3	0.40492543
86	MKNK1	0.40106283
87	NTRK3	0.39996153
88	MAP3K4	0.39864311
89	CSNK1A1	0.39661476
90	ZAP70	0.35850359
91	PRKCA	0.35185515
92	PIM2	0.35082937
93	MST4	0.29552196
94	MAPK4	0.29142536
95	CSNK2A1	0.28857945
96	CSNK2A2	0.28071499
97	PRKCE	0.28035414
98	MATK	0.27731793
99	TIE1	0.27645841
100	PRKCG	0.26404979

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.61787960
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.38398185
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.04829396
4	Ribosome_Homo sapiens_hsa03010	2.98748954
5	Parkinsons disease_Homo sapiens_hsa05012	2.97435105
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.93780075
7	Allograft rejection_Homo sapiens_hsa05330	2.83152884
8	Asthma_Homo sapiens_hsa05310	2.50812477
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.34288495
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.34233595
11	Antigen processing and presentation_Homo sapiens_hsa04612	2.20730742
12	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.19701340
13	Proteasome_Homo sapiens_hsa03050	2.18693495
14	Alzheimers disease_Homo sapiens_hsa05010	2.08701019
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.98326325
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.90049956
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.88144974
18	Huntingtons disease_Homo sapiens_hsa05016	1.82775647
19	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.77799885
20	One carbon pool by folate_Homo sapiens_hsa00670	1.67118052
21	Rheumatoid arthritis_Homo sapiens_hsa05323	1.64324789
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.59932322
23	Phototransduction_Homo sapiens_hsa04744	1.48341633
24	RNA polymerase_Homo sapiens_hsa03020	1.47289559
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.47035534
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.44164554
27	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.41360834
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.31598538
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.28020781
30	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.27087578
31	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.25593578
32	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.23735512
33	Caffeine metabolism_Homo sapiens_hsa00232	1.12110031
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.09781262
35	Sulfur metabolism_Homo sapiens_hsa00920	1.06639182
36	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.05999322
37	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.03254618
38	Retinol metabolism_Homo sapiens_hsa00830	1.03091755
39	Viral myocarditis_Homo sapiens_hsa05416	1.02083765
40	Peroxisome_Homo sapiens_hsa04146	1.01977699
41	Sulfur relay system_Homo sapiens_hsa04122	1.01422417
42	Chemical carcinogenesis_Homo sapiens_hsa05204	0.97696851
43	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.94912574
44	RNA degradation_Homo sapiens_hsa03018	0.93285566
45	Basal transcription factors_Homo sapiens_hsa03022	0.88328545
46	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.85614684
47	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.84602392
48	Collecting duct acid secretion_Homo sapiens_hsa04966	0.83888902
49	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.82934853
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.82627774
51	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.82036826
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.80358734
53	Protein export_Homo sapiens_hsa03060	0.78306307
54	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.77931881
55	Homologous recombination_Homo sapiens_hsa03440	0.76549174
56	Leishmaniasis_Homo sapiens_hsa05140	0.74998115
57	Nicotine addiction_Homo sapiens_hsa05033	0.73728572
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.72119258
59	Olfactory transduction_Homo sapiens_hsa04740	0.71678161
60	Fanconi anemia pathway_Homo sapiens_hsa03460	0.69718270
61	Tryptophan metabolism_Homo sapiens_hsa00380	0.67461862
62	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.65929991
63	Taste transduction_Homo sapiens_hsa04742	0.65011610
64	Alcoholism_Homo sapiens_hsa05034	0.65009281
65	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.60377349
66	Mineral absorption_Homo sapiens_hsa04978	0.60068056
67	Malaria_Homo sapiens_hsa05144	0.57609725
68	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.55489952
69	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.51686192
70	Folate biosynthesis_Homo sapiens_hsa00790	0.50391372
71	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.48843823
72	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.47059519
73	Ether lipid metabolism_Homo sapiens_hsa00565	0.43896142
74	Basal cell carcinoma_Homo sapiens_hsa05217	0.42436550
75	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.42412566
76	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.42092171
77	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.41761005
78	Salmonella infection_Homo sapiens_hsa05132	0.41056101
79	Tyrosine metabolism_Homo sapiens_hsa00350	0.39763126
80	Herpes simplex infection_Homo sapiens_hsa05168	0.39292973
81	Purine metabolism_Homo sapiens_hsa00230	0.38210992
82	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.36862680
83	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.33313710
84	Metabolic pathways_Homo sapiens_hsa01100	0.32648926
85	African trypanosomiasis_Homo sapiens_hsa05143	0.32373579
86	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.30868021
87	Morphine addiction_Homo sapiens_hsa05032	0.30540271
88	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.30536898
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.29849530
90	Regulation of autophagy_Homo sapiens_hsa04140	0.29346893
91	Pyrimidine metabolism_Homo sapiens_hsa00240	0.28700211
92	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.28279152
93	Salivary secretion_Homo sapiens_hsa04970	0.28134875
94	Serotonergic synapse_Homo sapiens_hsa04726	0.26677395
95	Circadian entrainment_Homo sapiens_hsa04713	0.25997176
96	Legionellosis_Homo sapiens_hsa05134	0.25630409
97	Pertussis_Homo sapiens_hsa05133	0.24704557
98	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.23854774
99	Fat digestion and absorption_Homo sapiens_hsa04975	0.23667625
100	Measles_Homo sapiens_hsa05162	0.22733143

RPL29P33

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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