

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of regulatory T cell differentiation (GO:0045589) | 4.76951145 |
| 2 | regulation of chronic inflammatory response (GO:0002676) | 4.68826534 |
| 3 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 4.59368270 |
| 4 | cytidine deamination (GO:0009972) | 4.27742706 |
| 5 | cytidine metabolic process (GO:0046087) | 4.27742706 |
| 6 | cytidine catabolic process (GO:0006216) | 4.27742706 |
| 7 | regulation of isotype switching to IgG isotypes (GO:0048302) | 4.26648740 |
| 8 | DNA deamination (GO:0045006) | 4.18406253 |
| 9 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 4.12516518 |
| 10 | proteasome assembly (GO:0043248) | 4.11129146 |
| 11 | positive regulation of interleukin-17 production (GO:0032740) | 4.04197617 |
| 12 | regulation of response to tumor cell (GO:0002834) | 3.99455146 |
| 13 | positive regulation of response to tumor cell (GO:0002836) | 3.99455146 |
| 14 | positive regulation of immune response to tumor cell (GO:0002839) | 3.99455146 |
| 15 | regulation of immune response to tumor cell (GO:0002837) | 3.99455146 |
| 16 | positive regulation of interleukin-10 production (GO:0032733) | 3.97976722 |
| 17 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.85029062 |
| 18 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.59864931 |
| 19 | positive regulation of isotype switching (GO:0045830) | 3.59752440 |
| 20 | maturation of SSU-rRNA (GO:0030490) | 3.55960150 |
| 21 | positive regulation of activated T cell proliferation (GO:0042104) | 3.52859776 |
| 22 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.51211919 |
| 23 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 3.43480019 |
| 24 | positive regulation of DNA recombination (GO:0045911) | 3.40459349 |
| 25 | activated T cell proliferation (GO:0050798) | 3.36794602 |
| 26 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.36366264 |
| 27 | negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665) | 3.34590164 |
| 28 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 3.32999144 |
| 29 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.32444118 |
| 30 | maturation of 5.8S rRNA (GO:0000460) | 3.30845601 |
| 31 | NADH metabolic process (GO:0006734) | 3.28251934 |
| 32 | GTP biosynthetic process (GO:0006183) | 3.25605996 |
| 33 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.25371061 |
| 34 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.25371061 |
| 35 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.25071535 |
| 36 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.25071535 |
| 37 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.25071535 |
| 38 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 3.24122730 |
| 39 | negative regulation of T-helper cell differentiation (GO:0045623) | 3.24122730 |
| 40 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 3.23544295 |
| 41 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 3.19040156 |
| 42 | respiratory chain complex IV assembly (GO:0008535) | 3.13496113 |
| 43 | positive regulation of B cell differentiation (GO:0045579) | 3.12521369 |
| 44 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.11842634 |
| 45 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.11842634 |
| 46 | pseudouridine synthesis (GO:0001522) | 3.09710732 |
| 47 | positive regulation of antigen processing and presentation (GO:0002579) | 3.05941969 |
| 48 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.05778067 |
| 49 | regulation of interleukin-10 production (GO:0032653) | 3.05718266 |
| 50 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.05672266 |
| 51 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.04906849 |
| 52 | necroptotic process (GO:0070266) | 3.04281102 |
| 53 | production of molecular mediator of immune response (GO:0002440) | 3.01888395 |
| 54 | positive regulation of interleukin-8 secretion (GO:2000484) | 3.01823813 |
| 55 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.00741568 |
| 56 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.99288622 |
| 57 | cellular response to ATP (GO:0071318) | 2.99030130 |
| 58 | base-excision repair, AP site formation (GO:0006285) | 2.98878048 |
| 59 | positive regulation of immunoglobulin production (GO:0002639) | 2.92798205 |
| 60 | regulation of immunoglobulin secretion (GO:0051023) | 2.89592758 |
| 61 | ATP synthesis coupled proton transport (GO:0015986) | 2.88660437 |
| 62 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.88660437 |
| 63 | positive regulation of B cell mediated immunity (GO:0002714) | 2.88390987 |
| 64 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 2.88390987 |
| 65 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.87611672 |
| 66 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 2.87248039 |
| 67 | DNA demethylation (GO:0080111) | 2.84731910 |
| 68 | chaperone-mediated protein transport (GO:0072321) | 2.84113241 |
| 69 | UTP biosynthetic process (GO:0006228) | 2.83260918 |
| 70 | DNA double-strand break processing (GO:0000729) | 2.82481356 |
| 71 | regulation of RIG-I signaling pathway (GO:0039535) | 2.82126598 |
| 72 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.81859579 |
| 73 | negative regulation of ligase activity (GO:0051352) | 2.81104346 |
| 74 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.81104346 |
| 75 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 2.78270262 |
| 76 | positive regulation of T cell migration (GO:2000406) | 2.77608328 |
| 77 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.76814653 |
| 78 | regulation of natural killer cell mediated immunity (GO:0002715) | 2.76494131 |
| 79 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 2.76494131 |
| 80 | positive regulation of cell killing (GO:0031343) | 2.75096257 |
| 81 | intestinal epithelial cell development (GO:0060576) | 2.73173427 |
| 82 | cytochrome complex assembly (GO:0017004) | 2.72552639 |
| 83 | cellular response to cadmium ion (GO:0071276) | 2.71894951 |
| 84 | rRNA modification (GO:0000154) | 2.71352646 |
| 85 | negative regulation of B cell proliferation (GO:0030889) | 2.70274506 |
| 86 | T-helper cell differentiation (GO:0042093) | 2.69344726 |
| 87 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 2.69344726 |
| 88 | regulation of interleukin-8 secretion (GO:2000482) | 2.66639405 |
| 89 | regulation of T cell mediated cytotoxicity (GO:0001914) | 2.65507924 |
| 90 | regulation of cellular extravasation (GO:0002691) | 2.64570070 |
| 91 | positive regulation of cell cycle arrest (GO:0071158) | 2.63696744 |
| 92 | pyrimidine ribonucleoside metabolic process (GO:0046131) | 2.62813468 |
| 93 | positive regulation of natural killer cell differentiation (GO:0032825) | 2.62421320 |
| 94 | negative regulation of nitric oxide biosynthetic process (GO:0045019) | 2.61012893 |
| 95 | positive regulation of lymphocyte mediated immunity (GO:0002708) | 2.60087911 |
| 96 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.59990823 |
| 97 | DNA replication checkpoint (GO:0000076) | 2.59184311 |
| 98 | UTP metabolic process (GO:0046051) | 2.59108304 |
| 99 | L-fucose metabolic process (GO:0042354) | 2.57913483 |
| 100 | L-fucose catabolic process (GO:0042355) | 2.57913483 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.39230898 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.17276567 |
| 3 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 4.02036575 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.76055577 |
| 5 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.54198618 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.29352675 |
| 7 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.21940937 |
| 8 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.87690791 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.83004257 |
| 10 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.74242757 |
| 11 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.61690910 |
| 12 | VDR_22108803_ChIP-Seq_LS180_Human | 2.57402063 |
| 13 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.38644912 |
| 14 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.37216600 |
| 15 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.34159255 |
| 16 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.25755858 |
| 17 | GATA1_22025678_ChIP-Seq_K562_Human | 2.24936824 |
| 18 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.13283031 |
| 19 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.05736597 |
| 20 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.00469296 |
| 21 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.93049465 |
| 22 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.87186121 |
| 23 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.87114316 |
| 24 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.83502871 |
| 25 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.71943590 |
| 26 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.69284481 |
| 27 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.68565153 |
| 28 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.67495204 |
| 29 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.66826648 |
| 30 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.66730545 |
| 31 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.63872625 |
| 32 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.63240020 |
| 33 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.61790098 |
| 34 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.61766669 |
| 35 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.56371669 |
| 36 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.56288043 |
| 37 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.51895996 |
| 38 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.49124549 |
| 39 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.44219787 |
| 40 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.43894607 |
| 41 | GATA3_26560356_Chip-Seq_TH2_Human | 1.41896747 |
| 42 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.40689664 |
| 43 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.35755452 |
| 44 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.35609627 |
| 45 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.34933805 |
| 46 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.33414525 |
| 47 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.32153415 |
| 48 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.32056874 |
| 49 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.29752168 |
| 50 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.28421076 |
| 51 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.26793105 |
| 52 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.26611461 |
| 53 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.25735047 |
| 54 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.25735047 |
| 55 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.24756950 |
| 56 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.23076227 |
| 57 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.22497036 |
| 58 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.21439904 |
| 59 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.20267097 |
| 60 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.20150870 |
| 61 | MYB_26560356_Chip-Seq_TH2_Human | 1.18458880 |
| 62 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.15729853 |
| 63 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.14682030 |
| 64 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.14545776 |
| 65 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.13252890 |
| 66 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.13011714 |
| 67 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.10987977 |
| 68 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.09556849 |
| 69 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.09532276 |
| 70 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.08537078 |
| 71 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.07891131 |
| 72 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.06449675 |
| 73 | AR_20517297_ChIP-Seq_VCAP_Human | 1.05032707 |
| 74 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.04695092 |
| 75 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.02057347 |
| 76 | NCOR_22424771_ChIP-Seq_293T_Human | 1.01797823 |
| 77 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.99743051 |
| 78 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.99443903 |
| 79 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.98876727 |
| 80 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.97733251 |
| 81 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 0.97711959 |
| 82 | ERA_21632823_ChIP-Seq_H3396_Human | 0.96484576 |
| 83 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.94886389 |
| 84 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.94507168 |
| 85 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.93044586 |
| 86 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.92754837 |
| 87 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.92754837 |
| 88 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.92754837 |
| 89 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.92465261 |
| 90 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.92328254 |
| 91 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.91970261 |
| 92 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.91816914 |
| 93 | SA1_27219007_Chip-Seq_Bcells_Human | 0.91198155 |
| 94 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.88961210 |
| 95 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.88337599 |
| 96 | SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.87114008 |
| 97 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.86873506 |
| 98 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.86670976 |
| 99 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.86450163 |
| 100 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.86198410 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001873_stomach_inflammation | 3.87557882 |
| 2 | MP0001348_abnormal_lacrimal_gland | 3.60379321 |
| 3 | MP0001835_abnormal_antigen_presentation | 3.45349277 |
| 4 | MP0002138_abnormal_hepatobiliary_system | 3.22294893 |
| 5 | MP0009333_abnormal_splenocyte_physiolog | 3.03940230 |
| 6 | MP0006082_CNS_inflammation | 2.95658522 |
| 7 | MP0005671_abnormal_response_to | 2.87241798 |
| 8 | MP0008875_abnormal_xenobiotic_pharmacok | 2.87154687 |
| 9 | MP0008872_abnormal_physiological_respon | 2.59795603 |
| 10 | MP0002163_abnormal_gland_morphology | 2.57298705 |
| 11 | MP0004147_increased_porphyrin_level | 2.48543654 |
| 12 | MP0009785_altered_susceptibility_to | 2.41430185 |
| 13 | MP0000685_abnormal_immune_system | 2.38799429 |
| 14 | MP0002148_abnormal_hypersensitivity_rea | 2.21370140 |
| 15 | MP0002876_abnormal_thyroid_physiology | 2.15116102 |
| 16 | MP0001790_abnormal_immune_system | 2.15032566 |
| 17 | MP0005387_immune_system_phenotype | 2.15032566 |
| 18 | MP0005360_urolithiasis | 2.10987725 |
| 19 | MP0005645_abnormal_hypothalamus_physiol | 2.07674853 |
| 20 | MP0010155_abnormal_intestine_physiology | 2.06000633 |
| 21 | MP0008058_abnormal_DNA_repair | 2.05930498 |
| 22 | MP0003303_peritoneal_inflammation | 2.03764532 |
| 23 | MP0001800_abnormal_humoral_immune | 1.95058659 |
| 24 | MP0003763_abnormal_thymus_physiology | 1.94545144 |
| 25 | MP0004145_abnormal_muscle_electrophysio | 1.91833789 |
| 26 | MP0003806_abnormal_nucleotide_metabolis | 1.88179757 |
| 27 | MP0001919_abnormal_reproductive_system | 1.85680355 |
| 28 | MP0005310_abnormal_salivary_gland | 1.70808635 |
| 29 | MP0005084_abnormal_gallbladder_morpholo | 1.68487262 |
| 30 | MP0005025_abnormal_response_to | 1.67390908 |
| 31 | MP0005000_abnormal_immune_tolerance | 1.67165301 |
| 32 | MP0005389_reproductive_system_phenotype | 1.66937100 |
| 33 | MP0002166_altered_tumor_susceptibility | 1.62199728 |
| 34 | MP0002723_abnormal_immune_serum | 1.58612386 |
| 35 | MP0003866_abnormal_defecation | 1.57066701 |
| 36 | MP0005379_endocrine/exocrine_gland_phen | 1.56619172 |
| 37 | MP0001663_abnormal_digestive_system | 1.55190775 |
| 38 | MP0002006_tumorigenesis | 1.53811174 |
| 39 | MP0002452_abnormal_antigen_presenting | 1.51917444 |
| 40 | MP0005085_abnormal_gallbladder_physiolo | 1.50326808 |
| 41 | MP0009379_abnormal_foot_pigmentation | 1.48623352 |
| 42 | MP0002420_abnormal_adaptive_immunity | 1.45041319 |
| 43 | MP0001666_abnormal_nutrient_absorption | 1.41043648 |
| 44 | MP0001845_abnormal_inflammatory_respons | 1.40159490 |
| 45 | MP0001819_abnormal_immune_cell | 1.39205280 |
| 46 | MP0001853_heart_inflammation | 1.37244988 |
| 47 | MP0003436_decreased_susceptibility_to | 1.36044118 |
| 48 | MP0009764_decreased_sensitivity_to | 1.36002501 |
| 49 | MP0003718_maternal_effect | 1.35516588 |
| 50 | MP0005408_hypopigmentation | 1.26948933 |
| 51 | MP0003724_increased_susceptibility_to | 1.26117290 |
| 52 | MP0005166_decreased_susceptibility_to | 1.24372377 |
| 53 | MP0006036_abnormal_mitochondrial_physio | 1.24237569 |
| 54 | MP0005174_abnormal_tail_pigmentation | 1.23327265 |
| 55 | MP0002139_abnormal_hepatobiliary_system | 1.21610599 |
| 56 | MP0005636_abnormal_mineral_homeostasis | 1.16336124 |
| 57 | MP0004019_abnormal_vitamin_homeostasis | 1.12662847 |
| 58 | MP0008469_abnormal_protein_level | 1.10335329 |
| 59 | MP0003693_abnormal_embryo_hatching | 1.09796108 |
| 60 | MP0003045_fibrosis | 1.09292009 |
| 61 | MP0001968_abnormal_touch/_nociception | 1.08103475 |
| 62 | MP0003567_abnormal_fetal_cardiomyocyte | 1.07616297 |
| 63 | MP0002277_abnormal_respiratory_mucosa | 1.05116832 |
| 64 | MP0003646_muscle_fatigue | 1.04433909 |
| 65 | MP0005410_abnormal_fertilization | 1.04060693 |
| 66 | MP0002405_respiratory_system_inflammati | 1.01541106 |
| 67 | MP0005165_increased_susceptibility_to | 1.00627270 |
| 68 | MP0004957_abnormal_blastocyst_morpholog | 1.00355083 |
| 69 | MP0001501_abnormal_sleep_pattern | 1.00215225 |
| 70 | MP0002419_abnormal_innate_immunity | 1.00020979 |
| 71 | MP0000716_abnormal_immune_system | 0.97270901 |
| 72 | MP0005381_digestive/alimentary_phenotyp | 0.97009314 |
| 73 | MP0005167_abnormal_blood-brain_barrier | 0.96804992 |
| 74 | MP0000689_abnormal_spleen_morphology | 0.95313105 |
| 75 | MP0000490_abnormal_crypts_of | 0.94980768 |
| 76 | MP0002398_abnormal_bone_marrow | 0.94136563 |
| 77 | MP0002160_abnormal_reproductive_system | 0.93842169 |
| 78 | MP0003786_premature_aging | 0.91620198 |
| 79 | MP0003186_abnormal_redox_activity | 0.91349292 |
| 80 | MP0001986_abnormal_taste_sensitivity | 0.91180630 |
| 81 | MP0004885_abnormal_endolymph | 0.89852454 |
| 82 | MP0001905_abnormal_dopamine_level | 0.88948238 |
| 83 | MP0003878_abnormal_ear_physiology | 0.88853483 |
| 84 | MP0005377_hearing/vestibular/ear_phenot | 0.88853483 |
| 85 | MP0005332_abnormal_amino_acid | 0.87556087 |
| 86 | MP0001764_abnormal_homeostasis | 0.85908844 |
| 87 | MP0009643_abnormal_urine_homeostasis | 0.85768908 |
| 88 | MP0002429_abnormal_blood_cell | 0.85517662 |
| 89 | MP0004782_abnormal_surfactant_physiolog | 0.85475820 |
| 90 | MP0005365_abnormal_bile_salt | 0.85152942 |
| 91 | MP0002102_abnormal_ear_morphology | 0.83850188 |
| 92 | MP0001664_abnormal_digestion | 0.82218815 |
| 93 | MP0005075_abnormal_melanosome_morpholog | 0.81662799 |
| 94 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.79400174 |
| 95 | MP0000477_abnormal_intestine_morphology | 0.79077539 |
| 96 | MP0003075_altered_response_to | 0.77729930 |
| 97 | MP0009765_abnormal_xenobiotic_induced | 0.76252618 |
| 98 | MP0002722_abnormal_immune_system | 0.75402651 |
| 99 | MP0001765_abnormal_ion_homeostasis | 0.74818522 |
| 100 | MP0001881_abnormal_mammary_gland | 0.74539853 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | 3-Methylglutaconic aciduria (HP:0003535) | 4.72989684 |
| 2 | Acute necrotizing encephalopathy (HP:0006965) | 4.42022009 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.10636076 |
| 4 | Hypoproteinemia (HP:0003075) | 3.91378070 |
| 5 | Progressive macrocephaly (HP:0004481) | 3.85886259 |
| 6 | Acute encephalopathy (HP:0006846) | 3.59248558 |
| 7 | Chronic diarrhea (HP:0002028) | 3.58958457 |
| 8 | Mitochondrial inheritance (HP:0001427) | 3.49016269 |
| 9 | Increased CSF lactate (HP:0002490) | 3.40253440 |
| 10 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.27365204 |
| 11 | Autoimmune hemolytic anemia (HP:0001890) | 3.24376629 |
| 12 | Hepatocellular necrosis (HP:0001404) | 3.23971742 |
| 13 | Cerebral edema (HP:0002181) | 3.09863508 |
| 14 | Stomatitis (HP:0010280) | 3.09071818 |
| 15 | Pulmonary infiltrates (HP:0002113) | 3.02882187 |
| 16 | Hepatic necrosis (HP:0002605) | 3.01478325 |
| 17 | Abnormality of the prostate (HP:0008775) | 2.94598166 |
| 18 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.85118722 |
| 19 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.85118722 |
| 20 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.81071511 |
| 21 | Increased serum lactate (HP:0002151) | 2.79611714 |
| 22 | Gastrointestinal infarctions (HP:0005244) | 2.76215400 |
| 23 | Lethargy (HP:0001254) | 2.73582156 |
| 24 | Ketoacidosis (HP:0001993) | 2.65985810 |
| 25 | Abnormality of the pons (HP:0007361) | 2.65953995 |
| 26 | IgG deficiency (HP:0004315) | 2.64733979 |
| 27 | Abnormality of T cell physiology (HP:0011840) | 2.60475089 |
| 28 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.60312669 |
| 29 | Fatigue (HP:0012378) | 2.57182487 |
| 30 | Exertional dyspnea (HP:0002875) | 2.53015799 |
| 31 | Abnormal albumin level (HP:0012116) | 2.50373544 |
| 32 | Hypoalbuminemia (HP:0003073) | 2.50373544 |
| 33 | Degeneration of anterior horn cells (HP:0002398) | 2.49905319 |
| 34 | Abnormality of the anterior horn cell (HP:0006802) | 2.49905319 |
| 35 | Exercise intolerance (HP:0003546) | 2.49545353 |
| 36 | Reduced antithrombin III activity (HP:0001976) | 2.48604190 |
| 37 | Optic disc pallor (HP:0000543) | 2.48207491 |
| 38 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.41158427 |
| 39 | Increased IgM level (HP:0003496) | 2.40414762 |
| 40 | Type I transferrin isoform profile (HP:0003642) | 2.39486911 |
| 41 | Increased intramyocellular lipid droplets (HP:0012240) | 2.36879777 |
| 42 | Lactic acidosis (HP:0003128) | 2.35582705 |
| 43 | Cerebral palsy (HP:0100021) | 2.33611304 |
| 44 | Abnormality of B cell number (HP:0010975) | 2.32538675 |
| 45 | Seborrheic dermatitis (HP:0001051) | 2.32262687 |
| 46 | Oral leukoplakia (HP:0002745) | 2.32164163 |
| 47 | Chest pain (HP:0100749) | 2.29753694 |
| 48 | Pulmonary fibrosis (HP:0002206) | 2.28656217 |
| 49 | Testicular atrophy (HP:0000029) | 2.28333322 |
| 50 | Abnormality of vitamin B metabolism (HP:0004340) | 2.27624170 |
| 51 | Generalized aminoaciduria (HP:0002909) | 2.27098839 |
| 52 | Aplastic anemia (HP:0001915) | 2.25536683 |
| 53 | Hypoplasia of the pons (HP:0012110) | 2.25531039 |
| 54 | Metabolic alkalosis (HP:0200114) | 2.25502643 |
| 55 | Respiratory failure (HP:0002878) | 2.18820390 |
| 56 | Abnormality of T cell number (HP:0011839) | 2.18806485 |
| 57 | Constricted visual fields (HP:0001133) | 2.18205391 |
| 58 | Abnormality of T cells (HP:0002843) | 2.17782794 |
| 59 | Skin rash (HP:0000988) | 2.17593438 |
| 60 | Increased muscle lipid content (HP:0009058) | 2.17088607 |
| 61 | Ketosis (HP:0001946) | 2.16873114 |
| 62 | Abnormal hemoglobin (HP:0011902) | 2.16637710 |
| 63 | Ureteral stenosis (HP:0000071) | 2.16106402 |
| 64 | Methylmalonic aciduria (HP:0012120) | 2.13720786 |
| 65 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 2.12616089 |
| 66 | Hypochromic anemia (HP:0001931) | 2.12163173 |
| 67 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.11267498 |
| 68 | Dicarboxylic aciduria (HP:0003215) | 2.11267498 |
| 69 | Abnormality of urine glucose concentration (HP:0011016) | 2.10582076 |
| 70 | Glycosuria (HP:0003076) | 2.10582076 |
| 71 | Alkalosis (HP:0001948) | 2.10312970 |
| 72 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.08775280 |
| 73 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.07337137 |
| 74 | Nausea (HP:0002018) | 2.06156785 |
| 75 | Amaurosis fugax (HP:0100576) | 2.04887541 |
| 76 | Leukodystrophy (HP:0002415) | 2.04825024 |
| 77 | Mediastinal lymphadenopathy (HP:0100721) | 2.02960705 |
| 78 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.02768385 |
| 79 | Hemoptysis (HP:0002105) | 2.01869676 |
| 80 | Progressive microcephaly (HP:0000253) | 2.01404704 |
| 81 | Amelogenesis imperfecta (HP:0000705) | 1.99052866 |
| 82 | Megaloblastic anemia (HP:0001889) | 1.97222034 |
| 83 | Conjunctival hamartoma (HP:0100780) | 1.96659815 |
| 84 | Vasculitis (HP:0002633) | 1.96590981 |
| 85 | Ureteral obstruction (HP:0006000) | 1.95902544 |
| 86 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.93443013 |
| 87 | Autoimmune thrombocytopenia (HP:0001973) | 1.85794689 |
| 88 | CNS demyelination (HP:0007305) | 1.84942921 |
| 89 | Cerebral hemorrhage (HP:0001342) | 1.84102083 |
| 90 | B lymphocytopenia (HP:0010976) | 1.83235513 |
| 91 | Pancreatitis (HP:0001733) | 1.83204585 |
| 92 | Tongue fasciculations (HP:0001308) | 1.81876913 |
| 93 | Pancytopenia (HP:0001876) | 1.81062964 |
| 94 | Pendular nystagmus (HP:0012043) | 1.79651325 |
| 95 | Abnormality of eosinophils (HP:0001879) | 1.79270052 |
| 96 | Eosinophilia (HP:0001880) | 1.77004523 |
| 97 | Chronic obstructive pulmonary disease (HP:0006510) | 1.74579056 |
| 98 | Obstructive lung disease (HP:0006536) | 1.74579056 |
| 99 | Concave nail (HP:0001598) | 1.73563159 |
| 100 | Abnormality of the pleura (HP:0002103) | 1.73496316 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 4.35461915 |
| 2 | TSSK6 | 4.03973823 |
| 3 | EIF2AK3 | 3.53123749 |
| 4 | VRK2 | 3.37651434 |
| 5 | TIE1 | 3.34694819 |
| 6 | EIF2AK1 | 3.28422931 |
| 7 | TLK1 | 3.20173583 |
| 8 | BMPR1B | 2.56420613 |
| 9 | GRK1 | 2.45481410 |
| 10 | MST4 | 2.39319773 |
| 11 | NEK1 | 2.16444113 |
| 12 | PBK | 2.11915609 |
| 13 | ADRBK2 | 1.97138818 |
| 14 | BCKDK | 1.85812339 |
| 15 | NME2 | 1.77288346 |
| 16 | FES | 1.77067661 |
| 17 | NME1 | 1.70591166 |
| 18 | IKBKB | 1.69499159 |
| 19 | ZAK | 1.68788318 |
| 20 | ITK | 1.62587885 |
| 21 | BUB1 | 1.61692777 |
| 22 | TEC | 1.59829693 |
| 23 | NUAK1 | 1.53537755 |
| 24 | FRK | 1.47535778 |
| 25 | SRPK1 | 1.46306045 |
| 26 | MAPKAPK3 | 1.41207864 |
| 27 | VRK1 | 1.39062470 |
| 28 | TAOK3 | 1.36684069 |
| 29 | MAP4K1 | 1.34930542 |
| 30 | JAK3 | 1.23646326 |
| 31 | MAP2K6 | 1.23491676 |
| 32 | IKBKE | 1.10757269 |
| 33 | TAF1 | 1.10615773 |
| 34 | KIT | 1.08966822 |
| 35 | MAP4K2 | 1.07785011 |
| 36 | CAMKK2 | 1.06489568 |
| 37 | OXSR1 | 1.02270494 |
| 38 | BCR | 0.90364692 |
| 39 | ACVR1B | 0.89123606 |
| 40 | PLK3 | 0.88503098 |
| 41 | TYK2 | 0.85230203 |
| 42 | PHKG1 | 0.83661927 |
| 43 | PHKG2 | 0.83661927 |
| 44 | PINK1 | 0.80720175 |
| 45 | KDR | 0.77935507 |
| 46 | WNK4 | 0.77274103 |
| 47 | EIF2AK2 | 0.75557223 |
| 48 | BTK | 0.74460067 |
| 49 | GRK6 | 0.72733959 |
| 50 | RIPK4 | 0.71954124 |
| 51 | DAPK1 | 0.70285264 |
| 52 | SMG1 | 0.69112300 |
| 53 | SYK | 0.68494754 |
| 54 | PASK | 0.68367682 |
| 55 | LCK | 0.65872489 |
| 56 | INSRR | 0.65657626 |
| 57 | CSK | 0.64386543 |
| 58 | ABL2 | 0.63118258 |
| 59 | BMPR2 | 0.62742696 |
| 60 | LYN | 0.58284157 |
| 61 | CLK1 | 0.58226151 |
| 62 | ERN1 | 0.56893902 |
| 63 | ALK | 0.56442787 |
| 64 | CSNK1A1 | 0.55618304 |
| 65 | CSNK1G3 | 0.55170131 |
| 66 | CSNK1G1 | 0.54800866 |
| 67 | ATR | 0.54016923 |
| 68 | MAP3K14 | 0.51851959 |
| 69 | IGF1R | 0.48954870 |
| 70 | PIM2 | 0.48527877 |
| 71 | DAPK2 | 0.48197313 |
| 72 | RPS6KB2 | 0.47546677 |
| 73 | TNIK | 0.47226991 |
| 74 | PDK2 | 0.46990211 |
| 75 | ZAP70 | 0.46580636 |
| 76 | TGFBR2 | 0.46252009 |
| 77 | TBK1 | 0.45014390 |
| 78 | RPS6KA5 | 0.43910793 |
| 79 | ADRBK1 | 0.43628842 |
| 80 | STK39 | 0.42409093 |
| 81 | CSNK1A1L | 0.42362251 |
| 82 | PRKCQ | 0.42339959 |
| 83 | PRKCA | 0.41999357 |
| 84 | MATK | 0.41988638 |
| 85 | PRKCD | 0.41787550 |
| 86 | PRKCI | 0.41175347 |
| 87 | CSNK2A2 | 0.37608631 |
| 88 | CSNK2A1 | 0.37229069 |
| 89 | MAP2K2 | 0.36247426 |
| 90 | GRK5 | 0.35983032 |
| 91 | PIM1 | 0.33988765 |
| 92 | NLK | 0.33870438 |
| 93 | CDK4 | 0.30401174 |
| 94 | PRKCE | 0.29395414 |
| 95 | MAPKAPK5 | 0.29077763 |
| 96 | AKT3 | 0.28854196 |
| 97 | PAK6 | 0.28274786 |
| 98 | DYRK2 | 0.28140031 |
| 99 | PRKACA | 0.27434522 |
| 100 | CAMKK1 | 0.27428072 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Asthma_Homo sapiens_hsa05310 | 4.48417545 |
| 2 | Allograft rejection_Homo sapiens_hsa05330 | 4.26059705 |
| 3 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 4.15448313 |
| 4 | Proteasome_Homo sapiens_hsa03050 | 3.98847071 |
| 5 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 3.35137245 |
| 6 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 3.14873698 |
| 7 | Graft-versus-host disease_Homo sapiens_hsa05332 | 3.12513099 |
| 8 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.36342357 |
| 9 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.32218129 |
| 10 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 2.27960637 |
| 11 | Ribosome_Homo sapiens_hsa03010 | 2.00697508 |
| 12 | Parkinsons disease_Homo sapiens_hsa05012 | 1.72830635 |
| 13 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.71623230 |
| 14 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.66896922 |
| 15 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.55278181 |
| 16 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.55228200 |
| 17 | Protein export_Homo sapiens_hsa03060 | 1.46500601 |
| 18 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.46061495 |
| 19 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.45753531 |
| 20 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.42965043 |
| 21 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.32212614 |
| 22 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.30004462 |
| 23 | DNA replication_Homo sapiens_hsa03030 | 1.20864071 |
| 24 | Mismatch repair_Homo sapiens_hsa03430 | 1.10674071 |
| 25 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.10090322 |
| 26 | Homologous recombination_Homo sapiens_hsa03440 | 1.08080086 |
| 27 | RNA polymerase_Homo sapiens_hsa03020 | 1.07807865 |
| 28 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.07619054 |
| 29 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.07258353 |
| 30 | Base excision repair_Homo sapiens_hsa03410 | 1.06868945 |
| 31 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.02316901 |
| 32 | Mineral absorption_Homo sapiens_hsa04978 | 1.01932869 |
| 33 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.00269555 |
| 34 | Alzheimers disease_Homo sapiens_hsa05010 | 1.00166166 |
| 35 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.99401790 |
| 36 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.97857182 |
| 37 | Huntingtons disease_Homo sapiens_hsa05016 | 0.96036240 |
| 38 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.95426890 |
| 39 | Phototransduction_Homo sapiens_hsa04744 | 0.94238404 |
| 40 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.93740980 |
| 41 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.92926978 |
| 42 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.89254222 |
| 43 | Viral myocarditis_Homo sapiens_hsa05416 | 0.88345963 |
| 44 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.86405580 |
| 45 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.85156089 |
| 46 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.84354039 |
| 47 | Leishmaniasis_Homo sapiens_hsa05140 | 0.82909152 |
| 48 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.81770654 |
| 49 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.79991298 |
| 50 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.79506848 |
| 51 | Spliceosome_Homo sapiens_hsa03040 | 0.78956897 |
| 52 | Measles_Homo sapiens_hsa05162 | 0.76568727 |
| 53 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.76524123 |
| 54 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.75232211 |
| 55 | RNA degradation_Homo sapiens_hsa03018 | 0.72601018 |
| 56 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.72388925 |
| 57 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.71447921 |
| 58 | RNA transport_Homo sapiens_hsa03013 | 0.71241224 |
| 59 | Purine metabolism_Homo sapiens_hsa00230 | 0.67171266 |
| 60 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.64782376 |
| 61 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.64742004 |
| 62 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.63260890 |
| 63 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.62429786 |
| 64 | Histidine metabolism_Homo sapiens_hsa00340 | 0.61832755 |
| 65 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.59451693 |
| 66 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.58562551 |
| 67 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.57323257 |
| 68 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.56519277 |
| 69 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.56209888 |
| 70 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.55996542 |
| 71 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.55936883 |
| 72 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.55900073 |
| 73 | Retinol metabolism_Homo sapiens_hsa00830 | 0.55175001 |
| 74 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.54547549 |
| 75 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.53460427 |
| 76 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.52956509 |
| 77 | Metabolic pathways_Homo sapiens_hsa01100 | 0.52381620 |
| 78 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.51641752 |
| 79 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.50961349 |
| 80 | Peroxisome_Homo sapiens_hsa04146 | 0.50627330 |
| 81 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.50283596 |
| 82 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.49479439 |
| 83 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.48972529 |
| 84 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.47977602 |
| 85 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.47442776 |
| 86 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.46848186 |
| 87 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.46717580 |
| 88 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.46358596 |
| 89 | Basal transcription factors_Homo sapiens_hsa03022 | 0.44911422 |
| 90 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.43775496 |
| 91 | Sulfur relay system_Homo sapiens_hsa04122 | 0.42801073 |
| 92 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.42480189 |
| 93 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.41360390 |
| 94 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.40873979 |
| 95 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.39756214 |
| 96 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.39663448 |
| 97 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.38712479 |
| 98 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.38614755 |
| 99 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.37050520 |
| 100 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.35802566 |

