RPL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.51593439
2* viral transcription (GO:0019083)5.94525075
3* translational termination (GO:0006415)5.76973033
4maturation of SSU-rRNA (GO:0030490)5.30844987
5ribosomal small subunit biogenesis (GO:0042274)5.23087258
6* translational elongation (GO:0006414)5.20457014
7* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.00309818
8* cotranslational protein targeting to membrane (GO:0006613)4.88440260
9* protein targeting to ER (GO:0045047)4.86284008
10* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.76307715
11DNA unwinding involved in DNA replication (GO:0006268)4.71786985
12* establishment of protein localization to endoplasmic reticulum (GO:0072599)4.62407036
13* translational initiation (GO:0006413)4.58664023
14* protein localization to endoplasmic reticulum (GO:0070972)4.55073618
15DNA strand elongation involved in DNA replication (GO:0006271)4.51019320
16* viral life cycle (GO:0019058)4.50611189
17* cellular protein complex disassembly (GO:0043624)4.50039394
18ribosomal large subunit biogenesis (GO:0042273)4.36732235
19formation of translation preinitiation complex (GO:0001731)4.35158832
20DNA strand elongation (GO:0022616)4.34045626
21telomere maintenance via semi-conservative replication (GO:0032201)4.33161142
22* protein complex disassembly (GO:0043241)4.08385369
23DNA replication initiation (GO:0006270)3.98922257
24IMP biosynthetic process (GO:0006188)3.97944875
25ribonucleoprotein complex biogenesis (GO:0022613)3.91064409
26telomere maintenance via recombination (GO:0000722)3.85690898
27* macromolecular complex disassembly (GO:0032984)3.81390012
28* nuclear-transcribed mRNA catabolic process (GO:0000956)3.75834507
29nucleobase biosynthetic process (GO:0046112)3.68023721
30mitotic recombination (GO:0006312)3.64144115
31IMP metabolic process (GO:0046040)3.58172809
32* mRNA catabolic process (GO:0006402)3.57905204
33negative regulation of mRNA processing (GO:0050686)3.51379121
34* RNA catabolic process (GO:0006401)3.45630245
35telomere maintenance via telomere lengthening (GO:0010833)3.44628189
36regulation of translational fidelity (GO:0006450)3.39186589
37negative regulation of mRNA metabolic process (GO:1903312)3.37186953
38nucleotide-excision repair, DNA gap filling (GO:0006297)3.36776610
39regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.35178277
40* translation (GO:0006412)3.34345858
41protein localization to kinetochore (GO:0034501)3.33121030
42DNA deamination (GO:0045006)3.31547885
43rRNA processing (GO:0006364)3.30355758
44ribosome biogenesis (GO:0042254)3.28448777
45purine nucleobase biosynthetic process (GO:0009113)3.23179914
46rRNA metabolic process (GO:0016072)3.19209206
47* protein targeting to membrane (GO:0006612)3.15766995
48regulation of DNA damage checkpoint (GO:2000001)3.05106854
49negative regulation of RNA splicing (GO:0033119)3.04795433
50folic acid-containing compound biosynthetic process (GO:0009396)3.03374878
51mitotic nuclear envelope disassembly (GO:0007077)3.02860546
52CENP-A containing nucleosome assembly (GO:0034080)3.00793042
53antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.97686981
54antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.97686981
55DNA replication checkpoint (GO:0000076)2.96879102
56DNA duplex unwinding (GO:0032508)2.96503849
57DNA geometric change (GO:0032392)2.94583148
58chromatin remodeling at centromere (GO:0031055)2.90928790
59telomere maintenance (GO:0000723)2.90665285
60L-serine metabolic process (GO:0006563)2.89769404
61telomere organization (GO:0032200)2.89306485
62viral mRNA export from host cell nucleus (GO:0046784)2.85821320
63somatic diversification of immune receptors via somatic mutation (GO:0002566)2.85632823
64somatic hypermutation of immunoglobulin genes (GO:0016446)2.85632823
65pseudouridine synthesis (GO:0001522)2.84902738
66negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.82943937
67cellular component biogenesis (GO:0044085)2.82056095
68ribonucleoprotein complex assembly (GO:0022618)2.81338262
69translesion synthesis (GO:0019985)2.79497492
70DNA replication-independent nucleosome assembly (GO:0006336)2.79199437
71DNA replication-independent nucleosome organization (GO:0034724)2.79199437
72GMP metabolic process (GO:0046037)2.77943073
73establishment of integrated proviral latency (GO:0075713)2.76818407
74regulation of translational initiation (GO:0006446)2.76745037
75membrane disassembly (GO:0030397)2.76658632
76nuclear envelope disassembly (GO:0051081)2.76658632
77nuclear pore organization (GO:0006999)2.76232692
78negative regulation of translational initiation (GO:0045947)2.75370474
79protein localization to chromosome, centromeric region (GO:0071459)2.75243129
80tRNA aminoacylation for protein translation (GO:0006418)2.73853293
81transcription from mitochondrial promoter (GO:0006390)2.73072752
82peptidyl-arginine omega-N-methylation (GO:0035247)2.72187559
83negative regulation of erythrocyte differentiation (GO:0045647)2.71411489
84DNA replication-dependent nucleosome organization (GO:0034723)2.70870915
85DNA replication-dependent nucleosome assembly (GO:0006335)2.70870915
86transcription-coupled nucleotide-excision repair (GO:0006283)2.70553438
87mRNA splicing, via spliceosome (GO:0000398)2.70052015
88RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.70052015
89deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.69712123
90RNA splicing, via transesterification reactions (GO:0000375)2.69271987
91establishment of viral latency (GO:0019043)2.69074518
92nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.68660405
93positive regulation of granulocyte differentiation (GO:0030854)2.67201243
94RNA export from nucleus (GO:0006405)2.66509841
95definitive hemopoiesis (GO:0060216)2.66509838
96pentose-phosphate shunt (GO:0006098)2.66188223
97spliceosomal snRNP assembly (GO:0000387)2.66072425
98protein-DNA complex disassembly (GO:0032986)2.65468871
99nucleosome disassembly (GO:0006337)2.65468871
1003-UTR-mediated mRNA stabilization (GO:0070935)2.64757963
101ribonucleoprotein complex subunit organization (GO:0071826)2.64080772
102rRNA modification (GO:0000154)2.63263647
103tRNA aminoacylation (GO:0043039)2.63260988
104amino acid activation (GO:0043038)2.63260988
105spliceosomal tri-snRNP complex assembly (GO:0000244)2.63244189
106nuclear pore complex assembly (GO:0051292)2.62114834
107DNA topological change (GO:0006265)2.61408751
108ribosome assembly (GO:0042255)2.61187656
109NADPH regeneration (GO:0006740)2.61051314
110mismatch repair (GO:0006298)2.60713600
111positive regulation of gamma-delta T cell activation (GO:0046645)2.59284437
112histone H2A acetylation (GO:0043968)2.59261957
113ncRNA 3-end processing (GO:0043628)2.59068306
114postreplication repair (GO:0006301)2.58405600
115antigen processing and presentation of endogenous antigen (GO:0019883)2.58363919
116rRNA transcription (GO:0009303)2.58348479
117negative thymic T cell selection (GO:0045060)2.57700474
118positive regulation of B cell differentiation (GO:0045579)2.57019116
119negative regulation of DNA repair (GO:0045738)2.56818517
120ncRNA processing (GO:0034470)2.56808129
121negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.56413186
122non-recombinational repair (GO:0000726)2.56025952
123double-strand break repair via nonhomologous end joining (GO:0006303)2.56025952
124termination of RNA polymerase II transcription (GO:0006369)2.55391091
125poly(A)+ mRNA export from nucleus (GO:0016973)2.55374205
126* gene expression (GO:0010467)2.55320928
127T cell apoptotic process (GO:0070231)2.53511471
128histone H4-K8 acetylation (GO:0043982)2.52608075
129histone H4-K5 acetylation (GO:0043981)2.52608075
130kinetochore organization (GO:0051383)2.52396457
131positive regulation of histone H3-K4 methylation (GO:0051571)2.52341888
132DNA ligation (GO:0006266)2.52333678
133alternative mRNA splicing, via spliceosome (GO:0000380)2.51586635
134cell cycle G1/S phase transition (GO:0044843)2.50107783
135G1/S transition of mitotic cell cycle (GO:0000082)2.50107783
136regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.49229878
137base-excision repair (GO:0006284)2.48301670
138regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.47648171
139mitotic metaphase plate congression (GO:0007080)2.46485632
140regulation of histone H3-K9 methylation (GO:0051570)2.45975419

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.38729479
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.13768217
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.79545153
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.23805661
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.94521788
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.89036045
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86365004
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.69435023
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.62698397
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.60055580
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59230856
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.54407505
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.52074456
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.51591442
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.51064317
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.44784332
17* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.38327507
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.34777323
19* XRN2_22483619_ChIP-Seq_HELA_Human2.31650480
20MYC_22102868_ChIP-Seq_BL_Human2.28821550
21* VDR_23849224_ChIP-Seq_CD4+_Human2.26007865
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.22722762
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.21567027
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.19500352
25* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.12600614
26* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10547248
27* FOXP3_21729870_ChIP-Seq_TREG_Human2.07646137
28* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00410643
29CIITA_25753668_ChIP-Seq_RAJI_Human1.86924908
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.85214193
31* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81504303
32* TTF2_22483619_ChIP-Seq_HELA_Human1.80586144
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.80187420
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77060937
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.76469161
36ELK1_19687146_ChIP-ChIP_HELA_Human1.74595436
37DCP1A_22483619_ChIP-Seq_HELA_Human1.74577667
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74304860
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.74016772
40* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70730793
41GABP_19822575_ChIP-Seq_HepG2_Human1.70664699
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67674409
43ERG_20887958_ChIP-Seq_HPC-7_Mouse1.64870727
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.64091489
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63466431
46* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63448904
47SCL_19346495_ChIP-Seq_HPC-7_Human1.62612726
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60264592
49VDR_21846776_ChIP-Seq_THP-1_Human1.58764736
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57865252
51AR_21909140_ChIP-Seq_LNCAP_Human1.56440905
52MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.50138847
53* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49856602
54* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48407467
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.48262930
56SPI1_23547873_ChIP-Seq_NB4_Human1.45532807
57* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44867020
58* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44772388
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.44347082
60CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40455177
61IRF8_22096565_ChIP-ChIP_GC-B_Human1.36320887
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.33653265
63* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33642873
64KDM5A_27292631_Chip-Seq_BREAST_Human1.31407277
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28844432
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27095837
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26395549
68* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25588604
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24507847
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.23340146
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.22466488
72* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19913767
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18642055
74MYB_26560356_Chip-Seq_TH2_Human1.16332151
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15639576
76MAF_26560356_Chip-Seq_TH2_Human1.14639199
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14605851
78TFEB_21752829_ChIP-Seq_HELA_Human1.13731912
79* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11704066
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10909470
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10909470
82KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10909470
83MAF_26560356_Chip-Seq_TH1_Human1.08292458
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07766631
85MYB_26560356_Chip-Seq_TH1_Human1.06859057
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.06312720
87STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.05975864
88FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.04464641
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04212936
90UTX_26944678_Chip-Seq_JUKART_Human1.03659178
91RUNX1_22412390_ChIP-Seq_EML_Mouse1.02040830
92PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01873537
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00832935
94CHD1_26751641_Chip-Seq_LNCaP_Human1.00467841
95STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98247030
96* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98071852
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97844870
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96829746
99TCF7_22412390_ChIP-Seq_EML_Mouse0.96294081
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95615464
101KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95547921
102MYC_18940864_ChIP-ChIP_HL60_Human0.93487570
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92736321
104PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91542992
105NCOR1_26117541_ChIP-Seq_K562_Human0.90386539
106* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90291341
107* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90217372
108VDR_24763502_ChIP-Seq_THP-1_Human0.89792227
109* NANOG_21062744_ChIP-ChIP_HESCs_Human0.89498214
110IRF8_21731497_ChIP-ChIP_J774_Mouse0.89108520
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88989914
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88979580
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88661485
114ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86725131
115GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86628733
116NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85473134

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.14772840
2MP0002396_abnormal_hematopoietic_system3.93972391
3MP0010094_abnormal_chromosome_stability3.83478353
4MP0008057_abnormal_DNA_replication3.42282189
5MP0004957_abnormal_blastocyst_morpholog3.36162596
6MP0003077_abnormal_cell_cycle3.25029330
7MP0003111_abnormal_nucleus_morphology3.22960968
8MP0008058_abnormal_DNA_repair2.89518407
9MP0004808_abnormal_hematopoietic_stem2.71849370
10MP0008007_abnormal_cellular_replicative2.67229480
11MP0003763_abnormal_thymus_physiology2.57680756
12MP0001835_abnormal_antigen_presentation2.24862327
13MP0010352_gastrointestinal_tract_polyps2.22358378
14MP0000490_abnormal_crypts_of2.10177948
15MP0001545_abnormal_hematopoietic_system2.06327911
16MP0005397_hematopoietic_system_phenotyp2.06327911
17MP0002398_abnormal_bone_marrow2.05098559
18MP0002254_reproductive_system_inflammat2.01669982
19MP0002163_abnormal_gland_morphology1.98163078
20MP0002009_preneoplasia1.96256735
21MP0006054_spinal_hemorrhage1.88132009
22MP0005671_abnormal_response_to1.87110532
23MP0009333_abnormal_splenocyte_physiolog1.85853287
24MP0000685_abnormal_immune_system1.80207781
25MP0000703_abnormal_thymus_morphology1.76324053
26MP0002722_abnormal_immune_system1.76185183
27MP0000350_abnormal_cell_proliferation1.76117639
28MP0000689_abnormal_spleen_morphology1.72689423
29MP0001800_abnormal_humoral_immune1.67211732
30MP0008932_abnormal_embryonic_tissue1.65624965
31MP0000465_gastrointestinal_hemorrhage1.63537006
32MP0005174_abnormal_tail_pigmentation1.62707988
33MP0003786_premature_aging1.62490749
34MP0010307_abnormal_tumor_latency1.61357489
35MP0001730_embryonic_growth_arrest1.60726784
36MP0008995_early_reproductive_senescence1.59695373
37MP0002019_abnormal_tumor_incidence1.59620798
38MP0009379_abnormal_foot_pigmentation1.58940992
39MP0002420_abnormal_adaptive_immunity1.57970962
40MP0002166_altered_tumor_susceptibility1.57794823
41MP0002429_abnormal_blood_cell1.57068709
42MP0000716_abnormal_immune_system1.56450800
43MP0001819_abnormal_immune_cell1.54671203
44MP0003123_paternal_imprinting1.48876922
45MP0002452_abnormal_antigen_presenting1.48442683
46MP0009785_altered_susceptibility_to1.46038181
47MP0005220_abnormal_exocrine_pancreas1.45118762
48MP0001873_stomach_inflammation1.43859180
49MP0005075_abnormal_melanosome_morpholog1.42504093
50MP0002095_abnormal_skin_pigmentation1.41309920
51MP0001661_extended_life_span1.41245572
52MP0005464_abnormal_platelet_physiology1.39157603
53MP0009672_abnormal_birth_weight1.39151305
54MP0002723_abnormal_immune_serum1.38246744
55MP0000313_abnormal_cell_death1.37652726
56MP0005379_endocrine/exocrine_gland_phen1.37482560
57MP0002006_tumorigenesis1.34257133
58MP0010155_abnormal_intestine_physiology1.30266690
59MP0008877_abnormal_DNA_methylation1.29898569
60MP0005025_abnormal_response_to1.29322771
61MP0003866_abnormal_defecation1.28577418
62MP0002405_respiratory_system_inflammati1.27284825
63MP0001853_heart_inflammation1.26865060
64MP0009278_abnormal_bone_marrow1.24727155
65MP0010234_abnormal_vibrissa_follicle1.24627859
66MP0002796_impaired_skin_barrier1.24074961
67MP0005000_abnormal_immune_tolerance1.22286075
68MP0002080_prenatal_lethality1.20151028
69MP0001697_abnormal_embryo_size1.18183174
70MP0000858_altered_metastatic_potential1.16718179
71MP0003436_decreased_susceptibility_to1.15144282
72MP0006035_abnormal_mitochondrial_morpho1.14474458
73MP0005501_abnormal_skin_physiology1.13702018
74MP0003567_abnormal_fetal_cardiomyocyte1.12247057
75MP0002148_abnormal_hypersensitivity_rea1.07631000
76MP0005380_embryogenesis_phenotype1.06932116
77MP0001672_abnormal_embryogenesis/_devel1.06932116
78MP0002132_abnormal_respiratory_system1.03569474
79MP0005387_immune_system_phenotype1.02910742
80MP0001790_abnormal_immune_system1.02910742
81MP0003984_embryonic_growth_retardation1.01235903
82MP0002086_abnormal_extraembryonic_tissu0.99542047
83MP0002088_abnormal_embryonic_growth/wei0.98228396
84MP0006036_abnormal_mitochondrial_physio0.97940197
85MP0009697_abnormal_copulation0.95204400
86MP0003943_abnormal_hepatobiliary_system0.94069588
87MP0009703_decreased_birth_body0.92715367
88MP0004381_abnormal_hair_follicle0.92223355
89MP0004197_abnormal_fetal_growth/weight/0.92220274
90MP0003121_genomic_imprinting0.92049512
91MP0010030_abnormal_orbit_morphology0.90113277
92MP0002419_abnormal_innate_immunity0.90067178
93MP0000372_irregular_coat_pigmentation0.87752854
94MP0002084_abnormal_developmental_patter0.86635500
95MP0002085_abnormal_embryonic_tissue0.84600610
96MP0000613_abnormal_salivary_gland0.84374640
97MP0005023_abnormal_wound_healing0.83301988
98MP0001145_abnormal_male_reproductive0.82856070
99MP0004147_increased_porphyrin_level0.82085322
100MP0000678_abnormal_parathyroid_gland0.81610274
101MP0001845_abnormal_inflammatory_respons0.80550349
102MP0000598_abnormal_liver_morphology0.79791743
103MP0002938_white_spotting0.79626171
104MP0000477_abnormal_intestine_morphology0.78647566
105MP0001764_abnormal_homeostasis0.77984165
106MP0001348_abnormal_lacrimal_gland0.76388959
107MP0002111_abnormal_tail_morphology0.76037776
108MP0001293_anophthalmia0.74520221
109MP0002138_abnormal_hepatobiliary_system0.73396158
110MP0003806_abnormal_nucleotide_metabolis0.72844452
111MP0000358_abnormal_cell_content/0.72558537
112MP0003718_maternal_effect0.71849369
113MP0008260_abnormal_autophagy0.70509069
114MP0000015_abnormal_ear_pigmentation0.68767172
115MP0000653_abnormal_sex_gland0.67442563
116MP0002877_abnormal_melanocyte_morpholog0.67249019
117MP0002075_abnormal_coat/hair_pigmentati0.66975732
118MP0004947_skin_inflammation0.66902930
119MP0002160_abnormal_reproductive_system0.66663740
120MP0005384_cellular_phenotype0.65757930
121MP0002933_joint_inflammation0.62980729
122MP0003448_altered_tumor_morphology0.62956320
123MP0005621_abnormal_cell_physiology0.62877254
124MP0006292_abnormal_olfactory_placode0.62231499
125MP0004264_abnormal_extraembryonic_tissu0.60321493
126MP0003724_increased_susceptibility_to0.59587688
127MP0000371_diluted_coat_color0.59323657
128MP0001915_intracranial_hemorrhage0.58984696
129MP0002210_abnormal_sex_determination0.57597977
130MP0003186_abnormal_redox_activity0.57144265
131MP0002089_abnormal_postnatal_growth/wei0.53681194

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.76758514
2Abnormal number of erythroid precursors (HP:0012131)5.41633497
3Reticulocytopenia (HP:0001896)5.34352577
4Thrombocytosis (HP:0001894)4.91710852
5Aplastic anemia (HP:0001915)4.19577053
6Microvesicular hepatic steatosis (HP:0001414)4.02432177
7Colon cancer (HP:0003003)3.92095077
8IgM deficiency (HP:0002850)3.57941234
9Pallor (HP:0000980)3.55527585
1011 pairs of ribs (HP:0000878)3.52918746
11Macrocytic anemia (HP:0001972)3.43944167
12Birth length less than 3rd percentile (HP:0003561)3.29139298
13Myelodysplasia (HP:0002863)2.99723516
14Chronic otitis media (HP:0000389)2.97837956
15Petechiae (HP:0000967)2.89171904
16Oral leukoplakia (HP:0002745)2.83688964
17Amaurosis fugax (HP:0100576)2.82815181
18Elevated erythrocyte sedimentation rate (HP:0003565)2.77265591
19Agnosia (HP:0010524)2.75925169
20Progressive muscle weakness (HP:0003323)2.73801914
21Medulloblastoma (HP:0002885)2.65510035
22Basal cell carcinoma (HP:0002671)2.61315395
23Multiple enchondromatosis (HP:0005701)2.60673888
24Abnormality of endocrine pancreas physiology (HP:0012093)2.57582064
25Abnormality of the pancreatic islet cells (HP:0006476)2.57582064
26Lymphoma (HP:0002665)2.55407971
27Recurrent bronchitis (HP:0002837)2.53135519
28Selective tooth agenesis (HP:0001592)2.52585453
29Abnormality of T cell physiology (HP:0011840)2.48242862
30Abnormality of T cells (HP:0002843)2.46693080
31Severe combined immunodeficiency (HP:0004430)2.46057954
32Villous atrophy (HP:0011473)2.46037177
33Abnormality of small intestinal villus morphology (HP:0011472)2.46037177
34Recurrent viral infections (HP:0004429)2.43503704
35Abnormality of the anterior horn cell (HP:0006802)2.43223712
36Degeneration of anterior horn cells (HP:0002398)2.43223712
37Abnormality of methionine metabolism (HP:0010901)2.42608573
38Ependymoma (HP:0002888)2.42367667
39Chromsome breakage (HP:0040012)2.42319831
40Hypoglycemic seizures (HP:0002173)2.41426695
41Neoplasm of the adrenal cortex (HP:0100641)2.40336870
42Seborrheic dermatitis (HP:0001051)2.39754996
43Poikiloderma (HP:0001029)2.31896397
44Panhypogammaglobulinemia (HP:0003139)2.29406005
45Prominent metopic ridge (HP:0005487)2.25080006
46Absent thumb (HP:0009777)2.24777564
47Myositis (HP:0100614)2.23384155
48Microretrognathia (HP:0000308)2.20124425
49Cutaneous melanoma (HP:0012056)2.19814423
50Premature graying of hair (HP:0002216)2.17537312
51IgG deficiency (HP:0004315)2.17132568
52Urethral obstruction (HP:0000796)2.15456137
53Diastasis recti (HP:0001540)2.15009233
54Acute myeloid leukemia (HP:0004808)2.14183695
55Prolonged bleeding time (HP:0003010)2.13806216
56Asplenia (HP:0001746)2.12596267
57Aplasia/Hypoplasia of the thymus (HP:0010515)2.11653563
58Bone marrow hypocellularity (HP:0005528)2.10561652
59Hyperinsulinemic hypoglycemia (HP:0000825)2.09742493
60Combined immunodeficiency (HP:0005387)2.09314889
61Abnormality of the preputium (HP:0100587)2.09135694
62Abnormality of chromosome stability (HP:0003220)2.07739423
63Nephroblastoma (Wilms tumor) (HP:0002667)2.06020520
64Rough bone trabeculation (HP:0100670)2.06000421
65Neoplasm of the pancreas (HP:0002894)2.05916168
66Pancreatic islet-cell hyperplasia (HP:0004510)2.05590641
67T lymphocytopenia (HP:0005403)2.05192078
68Aplasia/Hypoplasia of the sacrum (HP:0008517)2.04685421
69Pancytopenia (HP:0001876)2.04073215
70Type I transferrin isoform profile (HP:0003642)2.02542753
71Abnormality of cells of the lymphoid lineage (HP:0012140)2.01384804
72Lymphopenia (HP:0001888)2.01142420
73Progressive external ophthalmoplegia (HP:0000590)2.00473286
74Horseshoe kidney (HP:0000085)1.99569495
75Abnormal delayed hypersensitivity skin test (HP:0002963)1.99291030
76Abnormality of the fingertips (HP:0001211)1.98543870
77Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96972094
78Missing ribs (HP:0000921)1.96629516
79Glossoptosis (HP:0000162)1.95989697
80Abnormality of B cell number (HP:0010975)1.95500420
81B lymphocytopenia (HP:0010976)1.95500420
82Optic nerve coloboma (HP:0000588)1.95280064
83Abnormal number of incisors (HP:0011064)1.93419839
84Aplasia/Hypoplasia of the spleen (HP:0010451)1.93345842
85Cellular immunodeficiency (HP:0005374)1.93181272
86Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92761119
87Patellar aplasia (HP:0006443)1.90563545
88Thoracic kyphosis (HP:0002942)1.90522453
89Viral hepatitis (HP:0006562)1.90504192
90Abnormality of the heme biosynthetic pathway (HP:0010472)1.89452439
91Abnormality of T cell number (HP:0011839)1.88851892
92Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.88416718
93Acute lymphatic leukemia (HP:0006721)1.87509172
94Carpal bone hypoplasia (HP:0001498)1.87058135
95Abnormality of homocysteine metabolism (HP:0010919)1.85572382
96Homocystinuria (HP:0002156)1.85572382
97Abnormality of the thymus (HP:0000777)1.84700395
98Premature ovarian failure (HP:0008209)1.84517014
99Abnormality of the metopic suture (HP:0005556)1.84164550
100High anterior hairline (HP:0009890)1.83454721
101Embryonal renal neoplasm (HP:0011794)1.82609440
102Muscle fiber atrophy (HP:0100295)1.82416048
103Squamous cell carcinoma (HP:0002860)1.82360019
104Abnormality of reticulocytes (HP:0004312)1.81767813
105Abnormality of DNA repair (HP:0003254)1.81454578
106Volvulus (HP:0002580)1.81057535
107Neoplasm of the colon (HP:0100273)1.80055893
108Meckel diverticulum (HP:0002245)1.79593262
109Aplasia/Hypoplasia of the patella (HP:0006498)1.77535765
110Entropion (HP:0000621)1.77331694
111Depressed nasal ridge (HP:0000457)1.76416689
112Increased nuchal translucency (HP:0010880)1.76155645
113Anteriorly placed anus (HP:0001545)1.75263807
114Gastrointestinal inflammation (HP:0004386)1.75231286
115Autoimmune hemolytic anemia (HP:0001890)1.75023161
116Irregular epiphyses (HP:0010582)1.73829957
117Abnormality of the ileum (HP:0001549)1.73764139
118Cellulitis (HP:0100658)1.73178633
119Deviation of the thumb (HP:0009603)1.72820932
120Neoplasm of the adrenal gland (HP:0100631)1.72436381
121Proximal placement of thumb (HP:0009623)1.72362615
122Agammaglobulinemia (HP:0004432)1.71818959
123Abnormality of the calcaneus (HP:0008364)1.71709463
124Type 2 muscle fiber atrophy (HP:0003554)1.71486929
125Breast hypoplasia (HP:0003187)1.70869011
126Triphalangeal thumb (HP:0001199)1.68845997
127Slow saccadic eye movements (HP:0000514)1.68645507
128Verrucae (HP:0200043)1.68319453
129Papilloma (HP:0012740)1.68319453
130Angiofibromas (HP:0010615)1.68129633
131Adenoma sebaceum (HP:0009720)1.68129633
132Abnormal gallbladder physiology (HP:0012438)1.66868266
133Cholecystitis (HP:0001082)1.66868266
134Abnormality of the prostate (HP:0008775)1.66579879
135Deep palmar crease (HP:0006191)1.66578518
136Respiratory difficulties (HP:0002880)1.66298804
137Rhabdomyosarcoma (HP:0002859)1.65915289
138Small intestinal stenosis (HP:0012848)1.65683327
139Duodenal stenosis (HP:0100867)1.65683327
140Sloping forehead (HP:0000340)1.65272560
141IgA deficiency (HP:0002720)1.64771705
142Atresia of the external auditory canal (HP:0000413)1.64108095
143Trismus (HP:0000211)1.62784852
144Recurrent fungal infections (HP:0002841)1.62490554
145Tongue fasciculations (HP:0001308)1.62457392
146Aplasia/Hypoplasia of the uvula (HP:0010293)1.62075474
147Abnormality of the thoracic spine (HP:0100711)1.61990480
148Broad palm (HP:0001169)1.61706278
149Pulmonary fibrosis (HP:0002206)1.61281828
150Colitis (HP:0002583)1.60277853
151Asymmetry of the thorax (HP:0001555)1.57664914
152Abnormality of dicarboxylic acid metabolism (HP:0010995)1.54650854
153Dicarboxylic aciduria (HP:0003215)1.54650854
154Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.54272402
155Anal stenosis (HP:0002025)1.53688400

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.92381897
2VRK23.80061315
3EEF2K3.57219856
4WEE13.30608743
5TSSK63.16478391
6CDC73.11439037
7PASK2.95801547
8BUB12.84856719
9MAP4K12.79177845
10NME22.78988765
11TGFBR12.78753284
12RPS6KB22.55119797
13PRPF4B2.52227523
14TAF12.14407924
15FLT32.08558297
16PBK1.95001656
17EIF2AK11.94682023
18STK161.93035621
19SRPK11.87953362
20MKNK11.77411851
21VRK11.75494377
22KIT1.74338250
23PKN21.71890650
24BTK1.70154848
25NEK21.70065709
26BRSK21.67666168
27NUAK11.61400349
28ACVR1B1.57783046
29ATR1.57609979
30MAP2K31.57578945
31PIM21.53616328
32LRRK21.52322901
33ZAP701.49260030
34TEC1.46781350
35TXK1.45765791
36EIF2AK31.41257693
37RPS6KA41.35687937
38CDK71.31833122
39STK101.30861703
40AURKB1.28978135
41JAK31.25344106
42FGFR21.23904294
43NEK11.17928268
44DYRK31.16962144
45PIM11.16832470
46BCKDK1.15687437
47FES1.14215893
48PLK11.13514075
49CDK41.11057168
50SCYL21.09906597
51PAK41.08307299
52CDK81.05679305
53CCNB11.04593288
54PLK31.04429312
55TLK11.02825072
56HIPK21.02422617
57CSF1R1.01848685
58TTK0.95245720
59SYK0.94151962
60CLK10.92804490
61MAP3K100.91956508
62FGFR40.91233223
63MAP3K80.90157603
64PLK40.89441338
65EIF2AK20.89350818
66TESK20.84076806
67MKNK20.83376107
68BRSK10.83193356
69CHEK10.83094426
70STK40.82824318
71MAPKAPK30.80807087
72GRK60.76188984
73TRIB30.74572033
74ITK0.72041833
75MST40.71061032
76TYK20.70770642
77LCK0.69073353
78PRKD30.67062280
79CDK190.66937689
80IKBKB0.64747092
81CDK90.63856130
82CHEK20.63819185
83ILK0.62898579
84CSNK2A20.62589913
85TAOK30.62365080
86ALK0.61673753
87TNK20.61271425
88LYN0.60731332
89ATM0.59032997
90ZAK0.58648064
91IRAK40.58393792
92CDK60.58137836
93SIK30.57350384
94MAP3K140.55577303
95MAP2K60.55137169
96MATK0.55114650
97IKBKE0.54692788
98BRD40.54665687
99RPS6KA60.54574296
100BLK0.54252371
101CDK20.53086858
102NME10.53072911
103MAP3K120.52494102
104HCK0.52268767
105CSNK2A10.51441080
106RPS6KC10.50690941
107RPS6KL10.50690941
108MAP4K20.49864261
109TBK10.49576464
110MAP2K20.49229495
111DAPK10.49214622
112AURKA0.47496497
113FGFR30.45910992
114KDR0.43440297
115MAP3K30.42265798
116RPS6KA50.42113183
117RPS6KB10.39763540
118NEK90.38722544
119PAK20.37607987
120NLK0.37602430
121CHUK0.37487680
122PDK20.36981128
123STK30.35886701
124CDK120.34387393
125EPHA20.33670596
126PAK10.32704028

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.83539533
2* Ribosome_Homo sapiens_hsa030104.72445789
3Mismatch repair_Homo sapiens_hsa034304.12930085
4Base excision repair_Homo sapiens_hsa034103.08221649
5Spliceosome_Homo sapiens_hsa030403.05749799
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.91675510
7Proteasome_Homo sapiens_hsa030502.80349251
8Nucleotide excision repair_Homo sapiens_hsa034202.70486521
9Homologous recombination_Homo sapiens_hsa034402.61414875
10RNA transport_Homo sapiens_hsa030132.53047712
11RNA polymerase_Homo sapiens_hsa030202.50914428
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.31362691
13Non-homologous end-joining_Homo sapiens_hsa034502.25257780
14Cell cycle_Homo sapiens_hsa041102.21942422
15Pyrimidine metabolism_Homo sapiens_hsa002402.12891404
16One carbon pool by folate_Homo sapiens_hsa006702.11501871
17Primary immunodeficiency_Homo sapiens_hsa053401.84302403
18RNA degradation_Homo sapiens_hsa030181.84264740
19Fanconi anemia pathway_Homo sapiens_hsa034601.72508694
20Antigen processing and presentation_Homo sapiens_hsa046121.56763307
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53569286
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51190275
23Carbon metabolism_Homo sapiens_hsa012001.40890820
24mRNA surveillance pathway_Homo sapiens_hsa030151.39152493
25Basal transcription factors_Homo sapiens_hsa030221.39052232
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38537684
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.34937738
28p53 signaling pathway_Homo sapiens_hsa041151.31734765
29Herpes simplex infection_Homo sapiens_hsa051681.26009534
30Epstein-Barr virus infection_Homo sapiens_hsa051691.21683711
31Purine metabolism_Homo sapiens_hsa002301.11422075
32Fatty acid elongation_Homo sapiens_hsa000621.10925313
33Measles_Homo sapiens_hsa051621.07005327
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04874943
35Legionellosis_Homo sapiens_hsa051341.04533473
36Protein export_Homo sapiens_hsa030601.02101605
37Systemic lupus erythematosus_Homo sapiens_hsa053221.00589361
38Viral carcinogenesis_Homo sapiens_hsa052031.00222408
39Hematopoietic cell lineage_Homo sapiens_hsa046400.94492370
40NF-kappa B signaling pathway_Homo sapiens_hsa040640.90933962
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88787320
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86944644
43HTLV-I infection_Homo sapiens_hsa051660.85872029
44Propanoate metabolism_Homo sapiens_hsa006400.85810326
45N-Glycan biosynthesis_Homo sapiens_hsa005100.83622556
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80475453
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.77956552
48Leishmaniasis_Homo sapiens_hsa051400.76502851
49Glutathione metabolism_Homo sapiens_hsa004800.76259986
50Lysine degradation_Homo sapiens_hsa003100.75794381
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75443773
52Pentose phosphate pathway_Homo sapiens_hsa000300.74669620
53Thyroid cancer_Homo sapiens_hsa052160.71534343
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70282205
55Shigellosis_Homo sapiens_hsa051310.70014729
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.69730765
57B cell receptor signaling pathway_Homo sapiens_hsa046620.69446589
58Fructose and mannose metabolism_Homo sapiens_hsa000510.69411006
59Hepatitis B_Homo sapiens_hsa051610.68994205
60Pyruvate metabolism_Homo sapiens_hsa006200.68052664
61Apoptosis_Homo sapiens_hsa042100.67405657
62Allograft rejection_Homo sapiens_hsa053300.65896347
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65511801
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62792966
65Acute myeloid leukemia_Homo sapiens_hsa052210.62378873
66Influenza A_Homo sapiens_hsa051640.62175909
67Chronic myeloid leukemia_Homo sapiens_hsa052200.60925050
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.60192548
69Small cell lung cancer_Homo sapiens_hsa052220.59822405
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57983431
71mTOR signaling pathway_Homo sapiens_hsa041500.55952776
72T cell receptor signaling pathway_Homo sapiens_hsa046600.55585941
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55349033
74Vitamin B6 metabolism_Homo sapiens_hsa007500.54840088
75Prostate cancer_Homo sapiens_hsa052150.53139826
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52473491
77Autoimmune thyroid disease_Homo sapiens_hsa053200.52153132
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.48705463
79Colorectal cancer_Homo sapiens_hsa052100.46852331
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46600732
81Biosynthesis of amino acids_Homo sapiens_hsa012300.44214013
82Notch signaling pathway_Homo sapiens_hsa043300.43754488
83Platelet activation_Homo sapiens_hsa046110.42753364
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.41983038
85MicroRNAs in cancer_Homo sapiens_hsa052060.41822813
86Toxoplasmosis_Homo sapiens_hsa051450.41418141
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41348600
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41016761
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40174741
90Alcoholism_Homo sapiens_hsa050340.39637870
91Sulfur relay system_Homo sapiens_hsa041220.39468607
92Viral myocarditis_Homo sapiens_hsa054160.39407703
93Endometrial cancer_Homo sapiens_hsa052130.38677724
94HIF-1 signaling pathway_Homo sapiens_hsa040660.38631382
95Asthma_Homo sapiens_hsa053100.38269728
96Inositol phosphate metabolism_Homo sapiens_hsa005620.37865179
97Oocyte meiosis_Homo sapiens_hsa041140.37191061
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36897107
99Galactose metabolism_Homo sapiens_hsa000520.36873693
100Selenocompound metabolism_Homo sapiens_hsa004500.36150040
101Non-small cell lung cancer_Homo sapiens_hsa052230.36105061
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35474043
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.35174622
104Osteoclast differentiation_Homo sapiens_hsa043800.33939161
105Folate biosynthesis_Homo sapiens_hsa007900.33630715
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.33432271
107Wnt signaling pathway_Homo sapiens_hsa043100.32802343
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31601507
109Basal cell carcinoma_Homo sapiens_hsa052170.31242311
110Toll-like receptor signaling pathway_Homo sapiens_hsa046200.31076277
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30645465
112Other glycan degradation_Homo sapiens_hsa005110.29738294
113Graft-versus-host disease_Homo sapiens_hsa053320.28688608
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28558136
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27765830
116Type I diabetes mellitus_Homo sapiens_hsa049400.26765811
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.26383868
118Metabolic pathways_Homo sapiens_hsa011000.26366446
119Pathways in cancer_Homo sapiens_hsa052000.24767296
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24640588
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24479269
122Vitamin digestion and absorption_Homo sapiens_hsa049770.24353847
123Pancreatic cancer_Homo sapiens_hsa052120.24270543
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24110656
125Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.23367017
126Pertussis_Homo sapiens_hsa051330.22765241
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22392425
128Fatty acid metabolism_Homo sapiens_hsa012120.20697746

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