ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.31109112
2	DNA deamination (GO:0045006)	4.78323169
3	response to pheromone (GO:0019236)	4.49896426
4	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.33554051
5	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.33554051
6	platelet dense granule organization (GO:0060155)	4.27715299
7	protein complex biogenesis (GO:0070271)	3.83557623
8	cytidine metabolic process (GO:0046087)	3.77712495
9	cytidine catabolic process (GO:0006216)	3.77712495
10	cytidine deamination (GO:0009972)	3.77712495
11	DNA double-strand break processing (GO:0000729)	3.59467215
12	mitochondrial respiratory chain complex assembly (GO:0033108)	3.50177160
13	respiratory chain complex IV assembly (GO:0008535)	3.47816744
14	L-fucose catabolic process (GO:0042355)	3.47452516
15	fucose catabolic process (GO:0019317)	3.47452516
16	L-fucose metabolic process (GO:0042354)	3.47452516
17	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.41597373
18	NADH dehydrogenase complex assembly (GO:0010257)	3.41597373
19	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.41597373
20	protein polyglutamylation (GO:0018095)	3.40129514
21	water-soluble vitamin biosynthetic process (GO:0042364)	3.39464231
22	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.38802969
23	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.37238591
24	cullin deneddylation (GO:0010388)	3.35108767
25	protein neddylation (GO:0045116)	3.32369352
26	axoneme assembly (GO:0035082)	3.31960886
27	indolalkylamine metabolic process (GO:0006586)	3.31701860
28	cytochrome complex assembly (GO:0017004)	3.26115888
29	pseudouridine synthesis (GO:0001522)	3.22572569
30	epithelial cilium movement (GO:0003351)	3.22571209
31	pyrimidine nucleobase catabolic process (GO:0006208)	3.20710007
32	ubiquinone biosynthetic process (GO:0006744)	3.15365464
33	protein deneddylation (GO:0000338)	3.13586848
34	protein-cofactor linkage (GO:0018065)	3.08328126
35	ubiquinone metabolic process (GO:0006743)	3.07386749
36	kynurenine metabolic process (GO:0070189)	3.06092013
37	tryptophan metabolic process (GO:0006568)	3.05489184
38	cellular ketone body metabolic process (GO:0046950)	3.03691563
39	photoreceptor cell maintenance (GO:0045494)	3.00898134
40	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.97663629
41	rRNA catabolic process (GO:0016075)	2.96889595
42	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.93687480
43	iron-sulfur cluster assembly (GO:0016226)	2.93413726
44	metallo-sulfur cluster assembly (GO:0031163)	2.93413726
45	indole-containing compound catabolic process (GO:0042436)	2.92231188
46	indolalkylamine catabolic process (GO:0046218)	2.92231188
47	tryptophan catabolic process (GO:0006569)	2.92231188
48	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.90583098
49	ATP synthesis coupled proton transport (GO:0015986)	2.83977666
50	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.83977666
51	inositol phosphate catabolic process (GO:0071545)	2.83720952
52	ketone body metabolic process (GO:1902224)	2.82215594
53	regulation of action potential (GO:0098900)	2.81005743
54	adaptation of signaling pathway (GO:0023058)	2.80380745
55	cellular response to ATP (GO:0071318)	2.80346810
56	DNA demethylation (GO:0080111)	2.77125476
57	purine deoxyribonucleotide metabolic process (GO:0009151)	2.77035708
58	preassembly of GPI anchor in ER membrane (GO:0016254)	2.74056535
59	adenosine metabolic process (GO:0046085)	2.73379297
60	negative regulation of mast cell activation (GO:0033004)	2.71102311
61	nucleobase catabolic process (GO:0046113)	2.70992381
62	base-excision repair, AP site formation (GO:0006285)	2.70509366
63	GPI anchor metabolic process (GO:0006505)	2.68728175
64	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.67270441
65	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.66140129
66	detection of light stimulus involved in sensory perception (GO:0050962)	2.65818812
67	detection of light stimulus involved in visual perception (GO:0050908)	2.65818812
68	electron transport chain (GO:0022900)	2.64904070
69	piRNA metabolic process (GO:0034587)	2.64680852
70	negative regulation of B cell apoptotic process (GO:0002903)	2.64015316
71	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.62965333
72	mannosylation (GO:0097502)	2.62824519
73	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.62388360
74	auditory receptor cell stereocilium organization (GO:0060088)	2.62129777
75	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.62116724
76	cell wall macromolecule catabolic process (GO:0016998)	2.61093962
77	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.60610670
78	inositol phosphate dephosphorylation (GO:0046855)	2.60610670
79	respiratory electron transport chain (GO:0022904)	2.60453183
80	anterograde synaptic vesicle transport (GO:0048490)	2.60192930
81	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.59000278
82	transmission of nerve impulse (GO:0019226)	2.58858095
83	glycosphingolipid biosynthetic process (GO:0006688)	2.58179407
84	tRNA processing (GO:0008033)	2.58159455
85	cell wall macromolecule metabolic process (GO:0044036)	2.58144441
86	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.56597709
87	positive regulation of mitochondrial fission (GO:0090141)	2.55102136
88	arginine catabolic process (GO:0006527)	2.54348008
89	intraciliary transport (GO:0042073)	2.53143324
90	positive regulation of prostaglandin secretion (GO:0032308)	2.52944021
91	rhodopsin mediated signaling pathway (GO:0016056)	2.52195838
92	regulation of cilium movement (GO:0003352)	2.51188880
93	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.50686330
94	cornea development in camera-type eye (GO:0061303)	2.49965291
95	negative regulation of telomere maintenance (GO:0032205)	2.48689840
96	cilium movement (GO:0003341)	2.48648941
97	retinal cone cell development (GO:0046549)	2.48606503
98	photoreceptor cell development (GO:0042461)	2.48396986
99	quinone biosynthetic process (GO:1901663)	2.47810188
100	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.47124905

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.59260576
2	VDR_22108803_ChIP-Seq_LS180_Human	3.48564224
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.43762377
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.03592363
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.03374625
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.97521783
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.53626381
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.51099420
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.34865202
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.31832735
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.31414706
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.11970357
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.10467796
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.96876161
15	EWS_26573619_Chip-Seq_HEK293_Human	1.95867344
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.94018627
17	TP53_22573176_ChIP-Seq_HFKS_Human	1.93193405
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.93061883
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.91859679
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.90838211
21	P300_19829295_ChIP-Seq_ESCs_Human	1.89270077
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.85993582
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.78026223
24	FUS_26573619_Chip-Seq_HEK293_Human	1.76481227
25	VDR_23849224_ChIP-Seq_CD4+_Human	1.69360807
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.66631536
27	ER_23166858_ChIP-Seq_MCF-7_Human	1.66438561
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.66333794
29	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.63444824
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.62891441
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.61620803
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.52154027
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.50969313
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.49725717
35	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.44958984
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44402905
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.44402905
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.43645285
39	NANOG_19829295_ChIP-Seq_ESCs_Human	1.43645285
40	AR_20517297_ChIP-Seq_VCAP_Human	1.41853015
41	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.37999097
42	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.37999097
43	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.36081337
44	NCOR_22424771_ChIP-Seq_293T_Human	1.33650222
45	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.33326557
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.31909732
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.30613667
48	AR_25329375_ChIP-Seq_VCAP_Human	1.28903360
49	FOXP3_21729870_ChIP-Seq_TREG_Human	1.28281601
50	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27503596
51	CBP_20019798_ChIP-Seq_JUKART_Human	1.26864016
52	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.26864016
53	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.25074293
54	RNF2_27304074_Chip-Seq_NSC_Mouse	1.23639837
55	TCF4_22108803_ChIP-Seq_LS180_Human	1.23533401
56	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.21984030
57	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.21407953
58	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.21162034
59	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.20409069
60	STAT3_23295773_ChIP-Seq_U87_Human	1.20140846
61	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.18897198
62	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18813396
63	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17570703
64	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.17021676
65	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.14876811
66	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.14808819
67	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.13820526
68	TCF4_23295773_ChIP-Seq_U87_Human	1.13582644
69	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.13027214
70	SMAD4_21799915_ChIP-Seq_A2780_Human	1.12874724
71	MYC_19829295_ChIP-Seq_ESCs_Human	1.11956332
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11512665
73	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.10816522
74	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.10262995
75	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.10175632
76	HOXB7_26014856_ChIP-Seq_BT474_Human	1.10104836
77	REST_21632747_ChIP-Seq_MESCs_Mouse	1.09570428
78	TAF2_19829295_ChIP-Seq_ESCs_Human	1.09307059
79	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09179148
80	NANOG_20526341_ChIP-Seq_ESCs_Human	1.08223044
81	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.07456619
82	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06349808
83	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.05446957
84	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.02505655
85	BCAT_22108803_ChIP-Seq_LS180_Human	1.02240241
86	ERA_21632823_ChIP-Seq_H3396_Human	1.01025451
87	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.00715997
88	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.00684559
89	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.00360372
90	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99850529
91	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99328087
92	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99188016
93	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.98723546
94	HTT_18923047_ChIP-ChIP_STHdh_Human	0.97341121
95	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.96414117
96	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.94544110
97	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.94543364
98	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.94341883
99	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.93141134
100	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.92794279

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003011_delayed_dark_adaptation	3.28412850
2	MP0002102_abnormal_ear_morphology	2.82951484
3	MP0002638_abnormal_pupillary_reflex	2.70189673
4	MP0000372_irregular_coat_pigmentation	2.61805364
5	MP0005646_abnormal_pituitary_gland	2.58356362
6	MP0002876_abnormal_thyroid_physiology	2.57785154
7	MP0005084_abnormal_gallbladder_morpholo	2.56364288
8	MP0002837_dystrophic_cardiac_calcinosis	2.49318504
9	MP0003646_muscle_fatigue	2.43437664
10	MP0005551_abnormal_eye_electrophysiolog	2.40866722
11	MP0005645_abnormal_hypothalamus_physiol	2.36442447
12	MP0001968_abnormal_touch/_nociception	2.35174671
13	MP0006276_abnormal_autonomic_nervous	2.29774269
14	MP0008875_abnormal_xenobiotic_pharmacok	2.17424410
15	MP0008872_abnormal_physiological_respon	2.13590074
16	MP0006072_abnormal_retinal_apoptosis	2.08842580
17	MP0005253_abnormal_eye_physiology	2.07297360
18	MP0009697_abnormal_copulation	2.05620872
19	MP0006292_abnormal_olfactory_placode	2.02670911
20	MP0003195_calcinosis	1.98831922
21	MP0005083_abnormal_biliary_tract	1.88436565
22	MP0003136_yellow_coat_color	1.87214885
23	MP0002736_abnormal_nociception_after	1.84124780
24	MP0002163_abnormal_gland_morphology	1.82388552
25	MP0004885_abnormal_endolymph	1.73104668
26	MP0009745_abnormal_behavioral_response	1.71750436
27	MP0005389_reproductive_system_phenotype	1.68881488
28	MP0003880_abnormal_central_pattern	1.68645795
29	MP0001919_abnormal_reproductive_system	1.61831143
30	MP0008877_abnormal_DNA_methylation	1.59690395
31	MP0002160_abnormal_reproductive_system	1.59080568
32	MP0002938_white_spotting	1.49353619
33	MP0000631_abnormal_neuroendocrine_gland	1.47135187
34	MP0001764_abnormal_homeostasis	1.46899516
35	MP0001984_abnormal_olfaction	1.46583354
36	MP0002653_abnormal_ependyma_morphology	1.43117763
37	MP0005423_abnormal_somatic_nervous	1.42332852
38	MP0005379_endocrine/exocrine_gland_phen	1.42115916
39	MP0005085_abnormal_gallbladder_physiolo	1.41755590
40	MP0001986_abnormal_taste_sensitivity	1.39914391
41	MP0004142_abnormal_muscle_tone	1.34489380
42	MP0002272_abnormal_nervous_system	1.32665865
43	MP0004147_increased_porphyrin_level	1.32562219
44	MP0003252_abnormal_bile_duct	1.31420461
45	MP0003806_abnormal_nucleotide_metabolis	1.26580982
46	MP0009046_muscle_twitch	1.24216954
47	MP0001905_abnormal_dopamine_level	1.23224583
48	MP0005187_abnormal_penis_morphology	1.22671684
49	MP0008789_abnormal_olfactory_epithelium	1.21581601
50	MP0002928_abnormal_bile_duct	1.20740716
51	MP0003718_maternal_effect	1.20436610
52	MP0001501_abnormal_sleep_pattern	1.19566242
53	MP0005410_abnormal_fertilization	1.15256548
54	MP0003186_abnormal_redox_activity	1.12496105
55	MP0001529_abnormal_vocalization	1.12468226
56	MP0005365_abnormal_bile_salt	1.12427344
57	MP0004145_abnormal_muscle_electrophysio	1.12229560
58	MP0002572_abnormal_emotion/affect_behav	1.10654175
59	MP0009764_decreased_sensitivity_to	1.08043940
60	MP0000427_abnormal_hair_cycle	1.07939033
61	MP0004133_heterotaxia	1.07728799
62	MP0002064_seizures	1.05807286
63	MP0003693_abnormal_embryo_hatching	1.05312486
64	MP0000647_abnormal_sebaceous_gland	1.03435020
65	MP0006036_abnormal_mitochondrial_physio	1.01509562
66	MP0008995_early_reproductive_senescence	0.98806843
67	MP0005075_abnormal_melanosome_morpholog	0.98590654
68	MP0003787_abnormal_imprinting	0.97242533
69	MP0002733_abnormal_thermal_nociception	0.96060426
70	MP0001486_abnormal_startle_reflex	0.95757861
71	MP0005647_abnormal_sex_gland	0.95644444
72	MP0002557_abnormal_social/conspecific_i	0.94660548
73	MP0008775_abnormal_heart_ventricle	0.94618903
74	MP0002752_abnormal_somatic_nervous	0.93967770
75	MP0001970_abnormal_pain_threshold	0.92541692
76	MP0002751_abnormal_autonomic_nervous	0.88326909
77	MP0003786_premature_aging	0.87590796
78	MP0002090_abnormal_vision	0.87422886
79	MP0001963_abnormal_hearing_physiology	0.87402773
80	MP0005391_vision/eye_phenotype	0.87309656
81	MP0002282_abnormal_trachea_morphology	0.86910518
82	MP0000026_abnormal_inner_ear	0.86300947
83	MP0000778_abnormal_nervous_system	0.85876986
84	MP0002184_abnormal_innervation	0.85539185
85	MP0003137_abnormal_impulse_conducting	0.85422171
86	MP0002063_abnormal_learning/memory/cond	0.84890438
87	MP0009780_abnormal_chondrocyte_physiolo	0.82519741
88	MP0000049_abnormal_middle_ear	0.82361333
89	MP0001502_abnormal_circadian_rhythm	0.82178455
90	MP0002234_abnormal_pharynx_morphology	0.81991755
91	MP0005174_abnormal_tail_pigmentation	0.81964824
92	MP0000566_synostosis	0.81192606
93	MP0005195_abnormal_posterior_eye	0.80942612
94	MP0002095_abnormal_skin_pigmentation	0.80316778
95	MP0004215_abnormal_myocardial_fiber	0.79787823
96	MP0004085_abnormal_heartbeat	0.78313005
97	MP0003698_abnormal_male_reproductive	0.78087519
98	MP0002735_abnormal_chemical_nociception	0.75961206
99	MP0000516_abnormal_urinary_system	0.75831177
100	MP0005367_renal/urinary_system_phenotyp	0.75831177

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.40877254
2	Pancreatic fibrosis (HP:0100732)	3.95490309
3	True hermaphroditism (HP:0010459)	3.79806501
4	Type II lissencephaly (HP:0007260)	3.56999857
5	Acute necrotizing encephalopathy (HP:0006965)	3.56747305
6	Abnormality of midbrain morphology (HP:0002418)	3.49970152
7	Molar tooth sign on MRI (HP:0002419)	3.49970152
8	Congenital stationary night blindness (HP:0007642)	3.49752195
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.47873499
10	Nephronophthisis (HP:0000090)	3.39826569
11	3-Methylglutaconic aciduria (HP:0003535)	3.39087828
12	Mitochondrial inheritance (HP:0001427)	3.22366468
13	Progressive macrocephaly (HP:0004481)	3.12527120
14	Acute encephalopathy (HP:0006846)	3.02983485
15	Retinal dysplasia (HP:0007973)	3.00422094
16	Increased CSF lactate (HP:0002490)	3.00138463
17	Abnormality of the renal medulla (HP:0100957)	2.86768522
18	Hepatocellular necrosis (HP:0001404)	2.82780093
19	Medial flaring of the eyebrow (HP:0010747)	2.79916292
20	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.76104222
21	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.76104222
22	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.68424974
23	Abnormality of the renal cortex (HP:0011035)	2.67018289
24	Lissencephaly (HP:0001339)	2.65200936
25	Attenuation of retinal blood vessels (HP:0007843)	2.56484384
26	Methylmalonic acidemia (HP:0002912)	2.55895969
27	Hepatic necrosis (HP:0002605)	2.52941711
28	Cystic liver disease (HP:0006706)	2.51161338
29	Ketoacidosis (HP:0001993)	2.48366389
30	Methylmalonic aciduria (HP:0012120)	2.41857851
31	Cerebellar dysplasia (HP:0007033)	2.41541270
32	Abnormality of the anterior horn cell (HP:0006802)	2.37319576
33	Degeneration of anterior horn cells (HP:0002398)	2.37319576
34	Abnormal rod and cone electroretinograms (HP:0008323)	2.33438654
35	Abolished electroretinogram (ERG) (HP:0000550)	2.30700689
36	Pachygyria (HP:0001302)	2.30388559
37	Occipital encephalocele (HP:0002085)	2.30374947
38	Abnormal biliary tract physiology (HP:0012439)	2.28861621
39	Bile duct proliferation (HP:0001408)	2.28861621
40	Sclerocornea (HP:0000647)	2.28549570
41	Anencephaly (HP:0002323)	2.28143489
42	Pendular nystagmus (HP:0012043)	2.25240080
43	Optic disc pallor (HP:0000543)	2.21486346
44	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.21415262
45	Inability to walk (HP:0002540)	2.21086938
46	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.18636450
47	Abnormality of alanine metabolism (HP:0010916)	2.18636450
48	Hyperalaninemia (HP:0003348)	2.18636450
49	Progressive inability to walk (HP:0002505)	2.18294771
50	Decreased central vision (HP:0007663)	2.17819860
51	Tubular atrophy (HP:0000092)	2.17454717
52	Chronic hepatic failure (HP:0100626)	2.16813812
53	Stomach cancer (HP:0012126)	2.16408854
54	Ketosis (HP:0001946)	2.15448007
55	Absent speech (HP:0001344)	2.14524463
56	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.14390556
57	Cerebral edema (HP:0002181)	2.13898329
58	Postaxial foot polydactyly (HP:0001830)	2.13864248
59	Abnormality of B cell number (HP:0010975)	2.12058951
60	Congenital hepatic fibrosis (HP:0002612)	2.11350146
61	Concave nail (HP:0001598)	2.10872438
62	Lipid accumulation in hepatocytes (HP:0006561)	2.09737663
63	Short tibia (HP:0005736)	2.09133730
64	Increased corneal curvature (HP:0100692)	2.09118515
65	Keratoconus (HP:0000563)	2.09118515
66	Gait imbalance (HP:0002141)	2.07719342
67	Tachypnea (HP:0002789)	2.06890826
68	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.06592016
69	Increased serum lactate (HP:0002151)	2.06121234
70	Congenital primary aphakia (HP:0007707)	2.04692335
71	Hypothermia (HP:0002045)	2.03559547
72	Hypoproteinemia (HP:0003075)	2.01628125
73	Increased hepatocellular lipid droplets (HP:0006565)	2.00105271
74	Lactic acidosis (HP:0003128)	1.99050902
75	Polydipsia (HP:0001959)	1.96737672
76	Abnormal drinking behavior (HP:0030082)	1.96737672
77	Nephrogenic diabetes insipidus (HP:0009806)	1.95704351
78	Intestinal atresia (HP:0011100)	1.94415424
79	Preaxial hand polydactyly (HP:0001177)	1.94095815
80	Renal cortical cysts (HP:0000803)	1.91843885
81	Hyperventilation (HP:0002883)	1.91533546
82	Increased intramyocellular lipid droplets (HP:0012240)	1.91316457
83	Lethargy (HP:0001254)	1.88393721
84	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.87539543
85	Gaze-evoked nystagmus (HP:0000640)	1.86908773
86	Genital tract atresia (HP:0001827)	1.85562626
87	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.82942197
88	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.81487494
89	Hyperglycinemia (HP:0002154)	1.81208443
90	Male pseudohermaphroditism (HP:0000037)	1.80159039
91	Renal Fanconi syndrome (HP:0001994)	1.80134204
92	Bilateral microphthalmos (HP:0007633)	1.78386086
93	Anophthalmia (HP:0000528)	1.78102133
94	Progressive microcephaly (HP:0000253)	1.77723644
95	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.77693124
96	Abnormal protein N-linked glycosylation (HP:0012347)	1.77693124
97	Abnormal protein glycosylation (HP:0012346)	1.77693124
98	Abnormal glycosylation (HP:0012345)	1.77693124
99	Amyotrophic lateral sclerosis (HP:0007354)	1.76699985
100	Respiratory failure (HP:0002878)	1.75839830

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.71080858
2	PINK1	2.99408167
3	TXK	2.64560695
4	WNK3	2.53890017
5	BCKDK	2.52886766
6	GRK1	2.49621859
7	NUAK1	2.45265897
8	ADRBK2	2.41182449
9	MAP4K2	2.35751979
10	BMPR1B	2.06326799
11	WNK4	1.96573972
12	MAPK13	1.85016343
13	TAOK3	1.84625345
14	ZAK	1.79760922
15	MAP2K7	1.67820928
16	CAMKK2	1.64453519
17	KDR	1.61629484
18	CSNK1G3	1.59818436
19	TRIM28	1.51798112
20	BCR	1.49168679
21	ERBB3	1.43365115
22	NME1	1.41787023
23	OXSR1	1.41044082
24	STK39	1.40866525
25	EIF2AK3	1.38645190
26	CSNK1G1	1.37629752
27	FLT3	1.36071665
28	TNIK	1.34930399
29	CSNK1G2	1.34867563
30	CSNK1A1L	1.34361881
31	MAP3K4	1.33333846
32	INSRR	1.32358864
33	CASK	1.28337875
34	MARK1	1.27625552
35	SRPK1	1.26566925
36	GRK7	1.23284810
37	DAPK2	1.21982253
38	PRKD3	1.20924718
39	TIE1	1.10881321
40	DYRK2	1.09937217
41	VRK2	1.03966564
42	TLK1	1.03714279
43	PRKCE	1.01864055
44	PRKCG	1.01405486
45	CCNB1	0.97407727
46	ADRBK1	0.93939549
47	PIM2	0.89203169
48	MST4	0.86527179
49	PAK3	0.84131615
50	LIMK1	0.83660370
51	MUSK	0.79746782
52	PHKG2	0.79637979
53	PHKG1	0.79637979
54	PDK2	0.77264498
55	PLK1	0.73379262
56	PRKCQ	0.72098845
57	BUB1	0.68865322
58	ACVR1B	0.68190170
59	VRK1	0.65293107
60	IKBKB	0.64752606
61	STK16	0.63159789
62	PRKCI	0.63080242
63	CSNK1A1	0.59710155
64	CAMK1	0.58744399
65	NTRK2	0.58626924
66	FER	0.57470017
67	ATR	0.57013722
68	RPS6KA5	0.55210777
69	MAPKAPK5	0.55103457
70	FGFR2	0.53517126
71	PLK3	0.51389023
72	KIT	0.51384101
73	PIK3CA	0.50868076
74	RPS6KA4	0.49909759
75	CAMK1D	0.49292061
76	PRKACA	0.49133623
77	PKN1	0.48274946
78	CAMK2A	0.48067491
79	ITK	0.47190998
80	BRSK2	0.46980119
81	GRK5	0.46159185
82	PLK2	0.45171505
83	ABL2	0.44675457
84	AURKA	0.44517244
85	EPHA4	0.43364785
86	PIK3CG	0.43178410
87	PRKCA	0.43142541
88	CAMKK1	0.41019371
89	MATK	0.38972981
90	PTK2B	0.38710471
91	ABL1	0.37137097
92	IGF1R	0.37072256
93	CHEK2	0.36283415
94	BMPR2	0.36248651
95	CSNK2A1	0.35172838
96	TESK2	0.34636819
97	PLK4	0.33837124
98	ERBB2	0.33503149
99	TEC	0.32694255
100	CAMK2D	0.32163441

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.30320067
2	Parkinsons disease_Homo sapiens_hsa05012	2.64714060
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.51111133
4	Phototransduction_Homo sapiens_hsa04744	2.50398950
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.43120594
6	Protein export_Homo sapiens_hsa03060	2.35121332
7	Proteasome_Homo sapiens_hsa03050	2.21904638
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.21574496
9	Linoleic acid metabolism_Homo sapiens_hsa00591	1.97111964
10	Huntingtons disease_Homo sapiens_hsa05016	1.90552725
11	Nitrogen metabolism_Homo sapiens_hsa00910	1.87806144
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.84193958
13	Homologous recombination_Homo sapiens_hsa03440	1.77782118
14	Butanoate metabolism_Homo sapiens_hsa00650	1.76239514
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.73915862
16	Alzheimers disease_Homo sapiens_hsa05010	1.72646376
17	RNA polymerase_Homo sapiens_hsa03020	1.65358748
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.63693773
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.61460689
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.61295128
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.55093910
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.54332625
23	Asthma_Homo sapiens_hsa05310	1.52928632
24	Propanoate metabolism_Homo sapiens_hsa00640	1.51343722
25	Steroid biosynthesis_Homo sapiens_hsa00100	1.50890941
26	Nicotine addiction_Homo sapiens_hsa05033	1.48037283
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.46186508
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.45004429
29	Ether lipid metabolism_Homo sapiens_hsa00565	1.42355893
30	Regulation of autophagy_Homo sapiens_hsa04140	1.40621795
31	Peroxisome_Homo sapiens_hsa04146	1.39299338
32	Collecting duct acid secretion_Homo sapiens_hsa04966	1.38186207
33	Fatty acid elongation_Homo sapiens_hsa00062	1.32001328
34	Olfactory transduction_Homo sapiens_hsa04740	1.26962024
35	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.26692592
36	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.26021996
37	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.22573849
38	beta-Alanine metabolism_Homo sapiens_hsa00410	1.20424952
39	RNA degradation_Homo sapiens_hsa03018	1.20005424
40	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.13864803
41	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.11499749
42	Caffeine metabolism_Homo sapiens_hsa00232	1.09400535
43	Cardiac muscle contraction_Homo sapiens_hsa04260	1.08533671
44	Primary immunodeficiency_Homo sapiens_hsa05340	1.08228029
45	Type I diabetes mellitus_Homo sapiens_hsa04940	1.07369982
46	Basal transcription factors_Homo sapiens_hsa03022	1.06521432
47	Pyrimidine metabolism_Homo sapiens_hsa00240	1.04845686
48	Purine metabolism_Homo sapiens_hsa00230	1.04553177
49	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.04423756
50	Morphine addiction_Homo sapiens_hsa05032	0.99883231
51	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.98350769
52	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.96139581
53	Glycerolipid metabolism_Homo sapiens_hsa00561	0.95754926
54	Retinol metabolism_Homo sapiens_hsa00830	0.94754071
55	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.94475721
56	Sulfur metabolism_Homo sapiens_hsa00920	0.93888033
57	Graft-versus-host disease_Homo sapiens_hsa05332	0.93673508
58	One carbon pool by folate_Homo sapiens_hsa00670	0.93529730
59	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.92908813
60	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.91524154
61	Nucleotide excision repair_Homo sapiens_hsa03420	0.89388268
62	Allograft rejection_Homo sapiens_hsa05330	0.88326259
63	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.88003585
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.87222384
65	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.86916399
66	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.85670293
67	Metabolic pathways_Homo sapiens_hsa01100	0.84952350
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84864513
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.83554252
70	Base excision repair_Homo sapiens_hsa03410	0.83041858
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.82577004
72	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.82079372
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.79798451
74	GABAergic synapse_Homo sapiens_hsa04727	0.79319517
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.79300415
76	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.79061821
77	ABC transporters_Homo sapiens_hsa02010	0.75623867
78	Rheumatoid arthritis_Homo sapiens_hsa05323	0.74938771
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.68683387
80	Sulfur relay system_Homo sapiens_hsa04122	0.65579781
81	Non-homologous end-joining_Homo sapiens_hsa03450	0.62515573
82	Histidine metabolism_Homo sapiens_hsa00340	0.62014434
83	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.61903283
84	Taste transduction_Homo sapiens_hsa04742	0.61389023
85	Circadian entrainment_Homo sapiens_hsa04713	0.59674751
86	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.57799108
87	Arginine and proline metabolism_Homo sapiens_hsa00330	0.54994458
88	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.53728525
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51548159
90	Salivary secretion_Homo sapiens_hsa04970	0.50490532
91	Circadian rhythm_Homo sapiens_hsa04710	0.45599551
92	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.44143111
93	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.43277261
94	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.42946333
95	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.41124016
96	Serotonergic synapse_Homo sapiens_hsa04726	0.39132415
97	Glutamatergic synapse_Homo sapiens_hsa04724	0.38306661
98	Insulin secretion_Homo sapiens_hsa04911	0.36807182
99	Fatty acid degradation_Homo sapiens_hsa00071	0.35872023
100	Fatty acid metabolism_Homo sapiens_hsa01212	0.30784992

RPL30P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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