ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of penile erection (GO:0060405)	9.14274545
2	behavioral response to ethanol (GO:0048149)	5.71527702
3	neuron fate determination (GO:0048664)	4.47478932
4	DNA double-strand break processing (GO:0000729)	4.33085560
5	positive regulation of dendritic spine morphogenesis (GO:0061003)	4.20091121
6	short-term memory (GO:0007614)	3.81347289
7	cornea development in camera-type eye (GO:0061303)	3.70271348
8	limb bud formation (GO:0060174)	3.63402814
9	regulation of pigment cell differentiation (GO:0050932)	3.61409913
10	response to pheromone (GO:0019236)	3.61235738
11	neural tube formation (GO:0001841)	3.58611019
12	inositol phosphate catabolic process (GO:0071545)	3.55291029
13	mitotic sister chromatid cohesion (GO:0007064)	3.52735014
14	pyrimidine nucleobase catabolic process (GO:0006208)	3.40340291
15	presynaptic membrane assembly (GO:0097105)	3.33372350
16	regulation of sarcomere organization (GO:0060297)	3.28322329
17	kinetochore assembly (GO:0051382)	3.27282607
18	axonal fasciculation (GO:0007413)	3.26336991
19	DNA damage response, detection of DNA damage (GO:0042769)	3.23299428
20	resolution of meiotic recombination intermediates (GO:0000712)	3.22642958
21	microtubule depolymerization (GO:0007019)	3.21359341
22	regulation of DNA endoreduplication (GO:0032875)	3.14919604
23	positive regulation of developmental pigmentation (GO:0048087)	3.14767352
24	glial cell proliferation (GO:0014009)	3.14630578
25	anterograde synaptic vesicle transport (GO:0048490)	3.13068585
26	negative regulation of potassium ion transport (GO:0043267)	3.08534833
27	kinetochore organization (GO:0051383)	3.07787963
28	regulation of feeding behavior (GO:0060259)	3.05983862
29	L-fucose catabolic process (GO:0042355)	3.05404211
30	fucose catabolic process (GO:0019317)	3.05404211
31	L-fucose metabolic process (GO:0042354)	3.05404211
32	sympathetic nervous system development (GO:0048485)	3.04806345
33	DNA replication-dependent nucleosome organization (GO:0034723)	3.00194172
34	DNA replication-dependent nucleosome assembly (GO:0006335)	3.00194172
35	protein polyglutamylation (GO:0018095)	2.96919212
36	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.91007698
37	nucleobase catabolic process (GO:0046113)	2.89793212
38	dentate gyrus development (GO:0021542)	2.89256502
39	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.88600445
40	negative regulation of mast cell activation (GO:0033004)	2.86753472
41	negative regulation of axon guidance (GO:1902668)	2.86640052
42	intraciliary transport (GO:0042073)	2.85601875
43	presynaptic membrane organization (GO:0097090)	2.84566442
44	establishment of nucleus localization (GO:0040023)	2.81822224
45	ketone body metabolic process (GO:1902224)	2.80574211
46	replication fork processing (GO:0031297)	2.80263956
47	righting reflex (GO:0060013)	2.80183190
48	centriole replication (GO:0007099)	2.78650687
49	kidney morphogenesis (GO:0060993)	2.77138895
50	olfactory bulb development (GO:0021772)	2.76630593
51	histone exchange (GO:0043486)	2.74350927
52	ganglion development (GO:0061548)	2.74283394
53	regulation of dendritic spine morphogenesis (GO:0061001)	2.72618389
54	regulation of telomere maintenance (GO:0032204)	2.70922773
55	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.67487916
56	inositol phosphate dephosphorylation (GO:0046855)	2.67487916
57	regulation of male gonad development (GO:2000018)	2.67324523
58	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.66130593
59	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.64691053
60	spinal cord motor neuron differentiation (GO:0021522)	2.64690005
61	retinal rod cell development (GO:0046548)	2.64666020
62	protein K6-linked ubiquitination (GO:0085020)	2.64223224
63	regulation of action potential (GO:0098900)	2.60005140
64	synapsis (GO:0007129)	2.59760364
65	negative regulation of JUN kinase activity (GO:0043508)	2.57196725
66	regulation of dendritic spine development (GO:0060998)	2.55726297
67	dendritic spine morphogenesis (GO:0060997)	2.54610911
68	positive regulation of adenylate cyclase activity (GO:0045762)	2.54349330
69	developmental pigmentation (GO:0048066)	2.54224819
70	spermatid nucleus differentiation (GO:0007289)	2.53117359
71	pancreas development (GO:0031016)	2.47807299
72	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.47025393
73	polyol catabolic process (GO:0046174)	2.46825506
74	lactate metabolic process (GO:0006089)	2.46414535
75	regulation of centriole replication (GO:0046599)	2.46361534
76	microtubule polymerization or depolymerization (GO:0031109)	2.46336223
77	adaptation of signaling pathway (GO:0023058)	2.45439154
78	positive regulation of mitochondrial fission (GO:0090141)	2.44721883
79	chromatin remodeling at centromere (GO:0031055)	2.43740183
80	lysine catabolic process (GO:0006554)	2.43708128
81	lysine metabolic process (GO:0006553)	2.43708128
82	recombinational repair (GO:0000725)	2.43702800
83	regulation of cilium movement (GO:0003352)	2.42862995
84	neuron cell-cell adhesion (GO:0007158)	2.42684694
85	parental behavior (GO:0060746)	2.42663965
86	dorsal/ventral axis specification (GO:0009950)	2.42343258
87	somite development (GO:0061053)	2.42274975
88	protein prenylation (GO:0018342)	2.42239314
89	prenylation (GO:0097354)	2.42239314
90	cullin deneddylation (GO:0010388)	2.40747538
91	anterograde axon cargo transport (GO:0008089)	2.40742727
92	double-strand break repair via homologous recombination (GO:0000724)	2.39714681
93	keratinocyte development (GO:0003334)	2.39312871
94	neuron recognition (GO:0008038)	2.38932686
95	positive regulation of vasodilation (GO:0045909)	2.38618258
96	cardiac ventricle formation (GO:0003211)	2.38365208
97	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.36722511
98	Sertoli cell development (GO:0060009)	2.36570070
99	CENP-A containing nucleosome assembly (GO:0034080)	2.35777751
100	acrosome assembly (GO:0001675)	2.34035828

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.56711794
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.05214916
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.97305096
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.96781940
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.93430732
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.70201703
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.68290960
8	VDR_22108803_ChIP-Seq_LS180_Human	2.65315454
9	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.47242644
10	FUS_26573619_Chip-Seq_HEK293_Human	2.42561378
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.40007981
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.38916956
13	EWS_26573619_Chip-Seq_HEK293_Human	2.31189787
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.25562616
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.16119781
16	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.11008385
17	P300_19829295_ChIP-Seq_ESCs_Human	2.10319897
18	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.08577585
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.05911472
20	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.00647558
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.97360090
22	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.91475892
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.87764406
24	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.75394186
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.74893255
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.72704418
27	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.68609434
28	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.67655459
29	SMAD4_21799915_ChIP-Seq_A2780_Human	1.66688023
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.65835423
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.65835423
32	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.65044350
33	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.63525911
34	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.63010836
35	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.60998521
36	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.58636918
37	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.58462469
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.57917631
39	ELK1_19687146_ChIP-ChIP_HELA_Human	1.56142194
40	RNF2_27304074_Chip-Seq_NSC_Mouse	1.56043521
41	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.51589321
42	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.51133873
43	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.49353690
44	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.49064962
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49019677
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.47507785
47	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.46317119
48	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.45686769
49	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.44128268
50	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.43582250
51	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.43317113
52	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.40767230
53	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40767230
54	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.39868973
55	BCAT_22108803_ChIP-Seq_LS180_Human	1.39447189
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.36611518
57	AR_25329375_ChIP-Seq_VCAP_Human	1.35468237
58	ER_23166858_ChIP-Seq_MCF-7_Human	1.35195283
59	EZH2_22144423_ChIP-Seq_EOC_Human	1.35008019
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.29613019
61	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.27174379
62	MYC_18940864_ChIP-ChIP_HL60_Human	1.26752490
63	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.24999725
64	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.22216245
65	REST_21632747_ChIP-Seq_MESCs_Mouse	1.20514888
66	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.20014587
67	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.19221495
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14781102
69	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.13917748
70	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.13909890
71	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.13821148
72	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.13332900
73	TCF4_23295773_ChIP-Seq_U87_Human	1.11546900
74	STAT3_23295773_ChIP-Seq_U87_Human	1.10495797
75	TCF4_22108803_ChIP-Seq_LS180_Human	1.10206513
76	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.09628655
77	SOX9_26525672_Chip-Seq_HEART_Mouse	1.08532969
78	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.08083362
79	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06925217
80	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.05733432
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.04671833
82	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.04106942
83	P53_22387025_ChIP-Seq_ESCs_Mouse	1.03608538
84	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.03102704
85	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.02921254
86	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.02186778
87	VDR_23849224_ChIP-Seq_CD4+_Human	1.02128027
88	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01784975
89	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.99851837
90	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.96624253
91	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.94009793
92	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.93783473
93	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.93493255
94	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.93373671
95	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.93247067
96	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.93160355
97	SOX2_19829295_ChIP-Seq_ESCs_Human	0.92498432
98	NANOG_19829295_ChIP-Seq_ESCs_Human	0.92498432
99	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91960002
100	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.91788917

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	3.92909852
2	MP0002102_abnormal_ear_morphology	3.76231098
3	MP0003787_abnormal_imprinting	3.44109421
4	MP0003121_genomic_imprinting	2.47943883
5	MP0005075_abnormal_melanosome_morpholog	2.45404034
6	MP0008877_abnormal_DNA_methylation	2.37035513
7	MP0003880_abnormal_central_pattern	2.27055355
8	MP0000569_abnormal_digit_pigmentation	2.17473451
9	MP0001529_abnormal_vocalization	2.16883068
10	MP0003122_maternal_imprinting	2.00446879
11	MP0008058_abnormal_DNA_repair	2.00383098
12	MP0005647_abnormal_sex_gland	1.95865784
13	MP0002938_white_spotting	1.91628528
14	MP0004885_abnormal_endolymph	1.88872233
15	MP0002735_abnormal_chemical_nociception	1.86683241
16	MP0003890_abnormal_embryonic-extraembry	1.84953158
17	MP0009745_abnormal_behavioral_response	1.83698445
18	MP0002751_abnormal_autonomic_nervous	1.81238524
19	MP0004270_analgesia	1.77621336
20	MP0009046_muscle_twitch	1.72576153
21	MP0005174_abnormal_tail_pigmentation	1.70073797
22	MP0010094_abnormal_chromosome_stability	1.67958085
23	MP0001968_abnormal_touch/_nociception	1.67865085
24	MP0000015_abnormal_ear_pigmentation	1.63552175
25	MP0002272_abnormal_nervous_system	1.54889497
26	MP0000778_abnormal_nervous_system	1.54137136
27	MP0006276_abnormal_autonomic_nervous	1.52078177
28	MP0008789_abnormal_olfactory_epithelium	1.51793888
29	MP0005386_behavior/neurological_phenoty	1.51040579
30	MP0004924_abnormal_behavior	1.51040579
31	MP0001485_abnormal_pinna_reflex	1.50443013
32	MP0000516_abnormal_urinary_system	1.49753953
33	MP0005367_renal/urinary_system_phenotyp	1.49753953
34	MP0005394_taste/olfaction_phenotype	1.46343209
35	MP0005499_abnormal_olfactory_system	1.46343209
36	MP0001293_anophthalmia	1.41136151
37	MP0005171_absent_coat_pigmentation	1.40496852
38	MP0002095_abnormal_skin_pigmentation	1.37432576
39	MP0002557_abnormal_social/conspecific_i	1.36836621
40	MP0003011_delayed_dark_adaptation	1.35589499
41	MP0002736_abnormal_nociception_after	1.30933541
42	MP0002572_abnormal_emotion/affect_behav	1.28279165
43	MP0001984_abnormal_olfaction	1.26420587
44	MP0000427_abnormal_hair_cycle	1.26156074
45	MP0005187_abnormal_penis_morphology	1.24039593
46	MP0005253_abnormal_eye_physiology	1.23344880
47	MP0003693_abnormal_embryo_hatching	1.21747695
48	MP0003195_calcinosis	1.21395046
49	MP0002638_abnormal_pupillary_reflex	1.20334932
50	MP0002064_seizures	1.20170914
51	MP0002184_abnormal_innervation	1.19677968
52	MP0000631_abnormal_neuroendocrine_gland	1.18269907
53	MP0000647_abnormal_sebaceous_gland	1.18180014
54	MP0000955_abnormal_spinal_cord	1.16408202
55	MP0003635_abnormal_synaptic_transmissio	1.15799089
56	MP0005248_abnormal_Harderian_gland	1.13889336
57	MP0004742_abnormal_vestibular_system	1.13576246
58	MP0003718_maternal_effect	1.12719612
59	MP0005408_hypopigmentation	1.12637958
60	MP0002160_abnormal_reproductive_system	1.12419511
61	MP0001986_abnormal_taste_sensitivity	1.10694621
62	MP0005645_abnormal_hypothalamus_physiol	1.08470379
63	MP0010307_abnormal_tumor_latency	1.08147498
64	MP0008007_abnormal_cellular_replicative	1.06945195
65	MP0003137_abnormal_impulse_conducting	1.06912644
66	MP0002063_abnormal_learning/memory/cond	1.06347183
67	MP0002067_abnormal_sensory_capabilities	1.06323800
68	MP0004215_abnormal_myocardial_fiber	1.06014800
69	MP0003943_abnormal_hepatobiliary_system	1.03779267
70	MP0006072_abnormal_retinal_apoptosis	1.03344836
71	MP0010030_abnormal_orbit_morphology	1.02471529
72	MP0005551_abnormal_eye_electrophysiolog	1.01165664
73	MP0002233_abnormal_nose_morphology	1.00937422
74	MP0003646_muscle_fatigue	1.00222044
75	MP0002734_abnormal_mechanical_nocicepti	0.99457577
76	MP0001486_abnormal_startle_reflex	0.97518061
77	MP0008057_abnormal_DNA_replication	0.93944518
78	MP0003755_abnormal_palate_morphology	0.92750054
79	MP0006292_abnormal_olfactory_placode	0.91019343
80	MP0003878_abnormal_ear_physiology	0.90955764
81	MP0005377_hearing/vestibular/ear_phenot	0.90955764
82	MP0000049_abnormal_middle_ear	0.88074058
83	MP0004043_abnormal_pH_regulation	0.87720416
84	MP0001286_abnormal_eye_development	0.87604132
85	MP0001501_abnormal_sleep_pattern	0.87424397
86	MP0003123_paternal_imprinting	0.87416288
87	MP0005389_reproductive_system_phenotype	0.87342020
88	MP0004133_heterotaxia	0.86495898
89	MP0002837_dystrophic_cardiac_calcinosis	0.86391095
90	MP0000372_irregular_coat_pigmentation	0.85166318
91	MP0002752_abnormal_somatic_nervous	0.84196517
92	MP0002152_abnormal_brain_morphology	0.83211597
93	MP0002210_abnormal_sex_determination	0.82839156
94	MP0003937_abnormal_limbs/digits/tail_de	0.82527815
95	MP0003861_abnormal_nervous_system	0.79932167
96	MP0001929_abnormal_gametogenesis	0.78409197
97	MP0001188_hyperpigmentation	0.77030868
98	MP0001324_abnormal_eye_pigmentation	0.76393625
99	MP0005391_vision/eye_phenotype	0.76075402
100	MP0000653_abnormal_sex_gland	0.75727082

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	5.45690732
2	Cortical dysplasia (HP:0002539)	4.71785052
3	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.64301749
4	Abnormal biliary tract physiology (HP:0012439)	3.23275720
5	Bile duct proliferation (HP:0001408)	3.23275720
6	Meckel diverticulum (HP:0002245)	3.19608937
7	Absent speech (HP:0001344)	3.16175701
8	Abnormality of midbrain morphology (HP:0002418)	3.14287968
9	Molar tooth sign on MRI (HP:0002419)	3.14287968
10	Neoplasm of the adrenal cortex (HP:0100641)	3.00581446
11	True hermaphroditism (HP:0010459)	2.99906863
12	Abnormality of the ileum (HP:0001549)	2.98383420
13	Bifid tongue (HP:0010297)	2.93916082
14	Abnormality of the labia minora (HP:0012880)	2.76498750
15	Retinal dysplasia (HP:0007973)	2.73943993
16	Pancreatic fibrosis (HP:0100732)	2.68656296
17	Volvulus (HP:0002580)	2.68648577
18	Abnormality of the preputium (HP:0100587)	2.66114353
19	Pancreatic cysts (HP:0001737)	2.65817419
20	Abnormality of chromosome stability (HP:0003220)	2.59835838
21	Aqueductal stenosis (HP:0002410)	2.58879076
22	Febrile seizures (HP:0002373)	2.57789139
23	Small intestinal stenosis (HP:0012848)	2.57526915
24	Duodenal stenosis (HP:0100867)	2.57526915
25	Abnormal lung lobation (HP:0002101)	2.57256137
26	Nephronophthisis (HP:0000090)	2.55547431
27	Disproportionate short-trunk short stature (HP:0003521)	2.55334097
28	Papilledema (HP:0001085)	2.54817842
29	Clubbing of toes (HP:0100760)	2.52594092
30	Epileptic encephalopathy (HP:0200134)	2.48592532
31	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.47652175
32	Gonadotropin excess (HP:0000837)	2.46465085
33	Medial flaring of the eyebrow (HP:0010747)	2.46180681
34	Intestinal atresia (HP:0011100)	2.44751054
35	Cupped ear (HP:0000378)	2.38335578
36	Widely spaced teeth (HP:0000687)	2.35741342
37	Large for gestational age (HP:0001520)	2.32029195
38	Abnormality of the duodenum (HP:0002246)	2.29275296
39	Ectopic kidney (HP:0000086)	2.22082830
40	Long foot (HP:0001833)	2.20719392
41	Small hand (HP:0200055)	2.19954141
42	Drooling (HP:0002307)	2.18647633
43	Renal cortical cysts (HP:0000803)	2.18331379
44	Astigmatism (HP:0000483)	2.17488967
45	Abnormality of the carotid arteries (HP:0005344)	2.14856186
46	Chromsome breakage (HP:0040012)	2.13795712
47	Gait imbalance (HP:0002141)	2.13736599
48	Hypsarrhythmia (HP:0002521)	2.07524342
49	Atonic seizures (HP:0010819)	2.07314197
50	Chronic hepatic failure (HP:0100626)	2.06438020
51	Epidermoid cyst (HP:0200040)	2.06157945
52	Narrow forehead (HP:0000341)	2.05299178
53	Abolished electroretinogram (ERG) (HP:0000550)	2.05014548
54	Neoplasm of the adrenal gland (HP:0100631)	2.03816932
55	Genital tract atresia (HP:0001827)	2.03398427
56	Sclerocornea (HP:0000647)	2.02893480
57	Sloping forehead (HP:0000340)	2.02831753
58	Dandy-Walker malformation (HP:0001305)	2.02827534
59	EEG with generalized epileptiform discharges (HP:0011198)	2.02254233
60	Nephrogenic diabetes insipidus (HP:0009806)	2.02015405
61	Congenital primary aphakia (HP:0007707)	1.98443597
62	Colon cancer (HP:0003003)	1.98231410
63	Abnormality of the renal cortex (HP:0011035)	1.97984529
64	Abnormality of the renal medulla (HP:0100957)	1.97576494
65	Excessive salivation (HP:0003781)	1.95600926
66	Vaginal atresia (HP:0000148)	1.95158439
67	Progressive inability to walk (HP:0002505)	1.94497572
68	Hyperinsulinemic hypoglycemia (HP:0000825)	1.92666575
69	Downturned corners of mouth (HP:0002714)	1.92579670
70	Epileptiform EEG discharges (HP:0011182)	1.92540634
71	Oculomotor apraxia (HP:0000657)	1.91670112
72	Polyphagia (HP:0002591)	1.89544772
73	Type II lissencephaly (HP:0007260)	1.89455991
74	Aganglionic megacolon (HP:0002251)	1.88868459
75	Absent thumb (HP:0009777)	1.86253263
76	Enlarged penis (HP:0000040)	1.82481699
77	Decreased muscle mass (HP:0003199)	1.82225715
78	Amblyopia (HP:0000646)	1.81790047
79	Congenital stationary night blindness (HP:0007642)	1.81407558
80	Hypoglycemic coma (HP:0001325)	1.81269613
81	Fair hair (HP:0002286)	1.81026897
82	Postaxial hand polydactyly (HP:0001162)	1.80491117
83	Submucous cleft hard palate (HP:0000176)	1.80405988
84	Breast carcinoma (HP:0003002)	1.79977647
85	Lissencephaly (HP:0001339)	1.79784623
86	Esotropia (HP:0000565)	1.79586746
87	Hepatoblastoma (HP:0002884)	1.75829677
88	Dialeptic seizures (HP:0011146)	1.75640983
89	Limb dystonia (HP:0002451)	1.73917501
90	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.73364962
91	Nephroblastoma (Wilms tumor) (HP:0002667)	1.71505293
92	Papillary thyroid carcinoma (HP:0002895)	1.70798611
93	Short philtrum (HP:0000322)	1.70737854
94	Rib fusion (HP:0000902)	1.68907999
95	Arteriovenous malformation (HP:0100026)	1.68812128
96	Adrenal hypoplasia (HP:0000835)	1.67634529
97	Thyroiditis (HP:0100646)	1.66411077
98	Median cleft lip (HP:0000161)	1.65480398
99	Gaze-evoked nystagmus (HP:0000640)	1.64477277
100	Inability to walk (HP:0002540)	1.64378652

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.16868891
2	ACVR1B	4.34907689
3	BMPR1B	4.30300696
4	WEE1	3.17027692
5	WNK3	3.04582831
6	MAP4K2	2.65373402
7	CASK	2.54323338
8	TRIM28	2.49169180
9	CCNB1	2.27947195
10	FGFR2	2.16908783
11	TNIK	2.16128555
12	MAP3K4	2.09089554
13	MARK1	2.02892794
14	BRSK2	1.91308918
15	TGFBR1	1.87247941
16	MKNK2	1.72982482
17	PLK3	1.71684587
18	BUB1	1.51709155
19	MAP2K7	1.49834352
20	ERBB3	1.48751921
21	PLK4	1.43462613
22	PLK2	1.43270896
23	OXSR1	1.21497494
24	CSNK1G1	1.19693232
25	EIF2AK3	1.18156936
26	BCR	1.16015207
27	TSSK6	1.14797395
28	MAPK13	1.14609709
29	EPHA4	1.12483645
30	ZAK	1.09891941
31	MINK1	1.09000363
32	DYRK2	1.07846233
33	PLK1	1.03525255
34	NEK1	1.01408173
35	PNCK	1.01073716
36	GRK1	1.00848514
37	ERBB4	0.89087360
38	CSNK1G2	0.88636065
39	PKN2	0.87384593
40	MKNK1	0.87102600
41	TTK	0.86926394
42	CSNK1G3	0.86780877
43	BRSK1	0.85309899
44	STK16	0.85309349
45	PRKCE	0.83312154
46	STK39	0.80601746
47	PRKCG	0.80174281
48	FLT3	0.78255249
49	EPHA3	0.76700676
50	NUAK1	0.76085580
51	ADRBK2	0.76013993
52	MST4	0.73861775
53	PINK1	0.73714803
54	CSNK1A1L	0.72120183
55	SRPK1	0.71169869
56	INSRR	0.70698029
57	ATM	0.70221196
58	STK38L	0.68993599
59	CDK3	0.67468451
60	EIF2AK2	0.66081941
61	NTRK3	0.64770394
62	ADRBK1	0.64611119
63	VRK1	0.62296318
64	PTK2B	0.61895652
65	YES1	0.60425248
66	SIK2	0.60291703
67	PAK3	0.59067372
68	MELK	0.56224229
69	CHEK2	0.54247306
70	NLK	0.52666887
71	UHMK1	0.52234573
72	ATR	0.51918576
73	STK11	0.49864587
74	TAOK3	0.42694148
75	FER	0.42296951
76	MAP2K4	0.41523588
77	CAMK2D	0.41346409
78	FGFR1	0.40609117
79	AURKB	0.40027200
80	STK3	0.39489707
81	CAMK2A	0.39471236
82	PRKAA1	0.39104818
83	DYRK3	0.38850075
84	DYRK1A	0.37975346
85	MARK3	0.36461999
86	SIK3	0.34873680
87	RPS6KA4	0.34434119
88	RPS6KB2	0.33190072
89	DAPK2	0.32764896
90	PRKACA	0.32007474
91	PRKDC	0.30686421
92	CSNK2A1	0.30145387
93	PRKACB	0.29664018
94	CHEK1	0.27548161
95	PRKCZ	0.25762556
96	CAMKK2	0.25608821
97	ROCK1	0.25069336
98	CSNK1E	0.23866994
99	GRK5	0.23107065
100	MAP2K1	0.22609690

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.35796550
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.34790138
3	Fanconi anemia pathway_Homo sapiens_hsa03460	2.86706945
4	Non-homologous end-joining_Homo sapiens_hsa03450	2.65335930
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.57333561
6	Butanoate metabolism_Homo sapiens_hsa00650	2.27659649
7	Homologous recombination_Homo sapiens_hsa03440	2.25924753
8	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.14429585
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.93261368
10	Nicotine addiction_Homo sapiens_hsa05033	1.92830180
11	Steroid biosynthesis_Homo sapiens_hsa00100	1.90770046
12	Phototransduction_Homo sapiens_hsa04744	1.78206313
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.78016797
14	Propanoate metabolism_Homo sapiens_hsa00640	1.76214420
15	RNA degradation_Homo sapiens_hsa03018	1.74577910
16	Basal transcription factors_Homo sapiens_hsa03022	1.71513664
17	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.66643512
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.61228829
19	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.59560185
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.58712843
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.56723112
22	Oocyte meiosis_Homo sapiens_hsa04114	1.46928286
23	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.46404524
24	Base excision repair_Homo sapiens_hsa03410	1.45976597
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.43705419
26	Insulin secretion_Homo sapiens_hsa04911	1.40118850
27	RNA polymerase_Homo sapiens_hsa03020	1.37039353
28	Regulation of autophagy_Homo sapiens_hsa04140	1.33298284
29	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.32522840
30	Proteasome_Homo sapiens_hsa03050	1.32114741
31	Amphetamine addiction_Homo sapiens_hsa05031	1.29620822
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.29135191
33	GABAergic synapse_Homo sapiens_hsa04727	1.28095991
34	Parkinsons disease_Homo sapiens_hsa05012	1.27194255
35	Oxidative phosphorylation_Homo sapiens_hsa00190	1.24682613
36	Circadian entrainment_Homo sapiens_hsa04713	1.24479920
37	Peroxisome_Homo sapiens_hsa04146	1.23439437
38	Dopaminergic synapse_Homo sapiens_hsa04728	1.23084801
39	Fatty acid elongation_Homo sapiens_hsa00062	1.21295244
40	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.15557075
41	Mismatch repair_Homo sapiens_hsa03430	1.11678875
42	Cell cycle_Homo sapiens_hsa04110	1.10880347
43	Fatty acid metabolism_Homo sapiens_hsa01212	1.10285502
44	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.08957648
45	Taste transduction_Homo sapiens_hsa04742	1.00055378
46	Huntingtons disease_Homo sapiens_hsa05016	0.98698320
47	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.98096490
48	Basal cell carcinoma_Homo sapiens_hsa05217	0.94294731
49	Olfactory transduction_Homo sapiens_hsa04740	0.93165031
50	Glutamatergic synapse_Homo sapiens_hsa04724	0.92397060
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.90379877
52	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.89279004
53	RNA transport_Homo sapiens_hsa03013	0.89221068
54	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.88489927
55	Nucleotide excision repair_Homo sapiens_hsa03420	0.87188565
56	Morphine addiction_Homo sapiens_hsa05032	0.87064718
57	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.85361641
58	Hippo signaling pathway_Homo sapiens_hsa04390	0.84545644
59	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.82679391
60	Lysine degradation_Homo sapiens_hsa00310	0.80352861
61	Fatty acid degradation_Homo sapiens_hsa00071	0.79874454
62	Circadian rhythm_Homo sapiens_hsa04710	0.78985058
63	Cocaine addiction_Homo sapiens_hsa05030	0.76291362
64	Alzheimers disease_Homo sapiens_hsa05010	0.75428044
65	DNA replication_Homo sapiens_hsa03030	0.72400162
66	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.70768764
67	p53 signaling pathway_Homo sapiens_hsa04115	0.69273508
68	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.67036832
69	Pyruvate metabolism_Homo sapiens_hsa00620	0.66272786
70	Serotonergic synapse_Homo sapiens_hsa04726	0.62700549
71	Melanogenesis_Homo sapiens_hsa04916	0.61376970
72	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.61330685
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.61102647
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.59567051
75	Collecting duct acid secretion_Homo sapiens_hsa04966	0.58119020
76	mRNA surveillance pathway_Homo sapiens_hsa03015	0.57488417
77	Wnt signaling pathway_Homo sapiens_hsa04310	0.55578923
78	Salivary secretion_Homo sapiens_hsa04970	0.54536557
79	Renin secretion_Homo sapiens_hsa04924	0.52909380
80	Long-term depression_Homo sapiens_hsa04730	0.50170730
81	Metabolic pathways_Homo sapiens_hsa01100	0.48882569
82	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.48441099
83	Cardiac muscle contraction_Homo sapiens_hsa04260	0.46813012
84	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.46122919
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45164043
86	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.44514190
87	Calcium signaling pathway_Homo sapiens_hsa04020	0.44006698
88	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.43902262
89	Purine metabolism_Homo sapiens_hsa00230	0.43891787
90	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.42742558
91	Alcoholism_Homo sapiens_hsa05034	0.42370040
92	Sphingolipid metabolism_Homo sapiens_hsa00600	0.42187491
93	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.41613059
94	Spliceosome_Homo sapiens_hsa03040	0.40617498
95	Gap junction_Homo sapiens_hsa04540	0.40366398
96	Chemical carcinogenesis_Homo sapiens_hsa05204	0.39706608
97	cAMP signaling pathway_Homo sapiens_hsa04024	0.38951822
98	beta-Alanine metabolism_Homo sapiens_hsa00410	0.37959753
99	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.37432121
100	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.36424879

RPL30P13

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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