ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	phenylpropanoid metabolic process (GO:0009698)	7.36799273
2	xenobiotic catabolic process (GO:0042178)	6.82355692
3	pharyngeal system development (GO:0060037)	5.97891113
4	somite development (GO:0061053)	5.50814615
5	chaperone-mediated protein transport (GO:0072321)	5.10180714
6	rRNA catabolic process (GO:0016075)	4.62965784
7	cell proliferation involved in metanephros development (GO:0072203)	4.51749067
8	astrocyte differentiation (GO:0048708)	4.48393604
9	cornea development in camera-type eye (GO:0061303)	4.29488707
10	ribosomal small subunit assembly (GO:0000028)	4.22116058
11	regulation of axon regeneration (GO:0048679)	4.20299896
12	regulation of neuron projection regeneration (GO:0070570)	4.20299896
13	cerebral cortex radially oriented cell migration (GO:0021799)	3.94868662
14	spinal cord motor neuron differentiation (GO:0021522)	3.93732462
15	behavioral response to nicotine (GO:0035095)	3.93580282
16	maturation of SSU-rRNA (GO:0030490)	3.90549788
17	limb development (GO:0060173)	3.88379533
18	appendage development (GO:0048736)	3.88379533
19	viral transcription (GO:0019083)	3.87157338
20	translational termination (GO:0006415)	3.77682206
21	positive regulation of vascular permeability (GO:0043117)	3.74125135
22	platelet dense granule organization (GO:0060155)	3.68609470
23	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.68387101
24	NADH dehydrogenase complex assembly (GO:0010257)	3.68387101
25	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.68387101
26	regulation of timing of cell differentiation (GO:0048505)	3.66142407
27	ncRNA catabolic process (GO:0034661)	3.63002017
28	artery development (GO:0060840)	3.62062314
29	protein deneddylation (GO:0000338)	3.61104837
30	magnesium ion transport (GO:0015693)	3.58419776
31	oxidative demethylation (GO:0070989)	3.52586935
32	cell proliferation involved in kidney development (GO:0072111)	3.52216198
33	cell proliferation in forebrain (GO:0021846)	3.46806384
34	neural tube formation (GO:0001841)	3.38652631
35	ribosomal large subunit biogenesis (GO:0042273)	3.35632876
36	benzene-containing compound metabolic process (GO:0042537)	3.33693395
37	negative regulation of multicellular organism growth (GO:0040015)	3.32095215
38	negative regulation of smoothened signaling pathway (GO:0045879)	3.30207434
39	positive regulation of neuroblast proliferation (GO:0002052)	3.28511953
40	regulation of telomere maintenance (GO:0032204)	3.28142313
41	nonmotile primary cilium assembly (GO:0035058)	3.26945026
42	retinal cone cell development (GO:0046549)	3.25883445
43	translational elongation (GO:0006414)	3.24679263
44	protein complex biogenesis (GO:0070271)	3.24109296
45	neuron fate determination (GO:0048664)	3.22610650
46	cranial nerve morphogenesis (GO:0021602)	3.22364498
47	pseudouridine synthesis (GO:0001522)	3.20870969
48	ribosomal small subunit biogenesis (GO:0042274)	3.18852092
49	regulation of development, heterochronic (GO:0040034)	3.17193538
50	maturation of 5.8S rRNA (GO:0000460)	3.14441584
51	axoneme assembly (GO:0035082)	3.12911969
52	negative regulation of telomere maintenance (GO:0032205)	3.12718254
53	positive regulation of cell fate commitment (GO:0010455)	3.08514216
54	pituitary gland development (GO:0021983)	3.04905238
55	protein polyglutamylation (GO:0018095)	3.04781781
56	smoothened signaling pathway (GO:0007224)	3.02776999
57	pyrimidine nucleobase catabolic process (GO:0006208)	3.01782220
58	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.01291551
59	cullin deneddylation (GO:0010388)	2.98605183
60	dorsal/ventral pattern formation (GO:0009953)	2.97038710
61	cotranslational protein targeting to membrane (GO:0006613)	2.95753218
62	regulation of cilium movement (GO:0003352)	2.95300092
63	mechanosensory behavior (GO:0007638)	2.94363105
64	protein targeting to ER (GO:0045047)	2.93781354
65	cellular response to cholesterol (GO:0071397)	2.93481018
66	response to gravity (GO:0009629)	2.90899726
67	cilium morphogenesis (GO:0060271)	2.85467155
68	keratinocyte proliferation (GO:0043616)	2.85411390
69	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.84658965
70	ATP synthesis coupled proton transport (GO:0015986)	2.84658965
71	negative regulation of systemic arterial blood pressure (GO:0003085)	2.83816928
72	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.83331854
73	regulation of translation, ncRNA-mediated (GO:0045974)	2.83331854
74	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.83331854
75	photoreceptor cell development (GO:0042461)	2.82805706
76	tongue development (GO:0043586)	2.82258809
77	mitochondrial respiratory chain complex assembly (GO:0033108)	2.81655993
78	viral life cycle (GO:0019058)	2.81180287
79	cellular response to sterol (GO:0036315)	2.80830880
80	RNA destabilization (GO:0050779)	2.79967870
81	cell differentiation in spinal cord (GO:0021515)	2.79553901
82	protein localization to microtubule (GO:0035372)	2.78054773
83	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.77123075
84	regulation of collateral sprouting (GO:0048670)	2.76061312
85	ovulation cycle (GO:0042698)	2.75850490
86	protein localization to endoplasmic reticulum (GO:0070972)	2.75211497
87	otic vesicle formation (GO:0030916)	2.72363626
88	hypothalamus development (GO:0021854)	2.71866646
89	pattern specification involved in kidney development (GO:0061004)	2.70328384
90	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.70322281
91	Sertoli cell development (GO:0060009)	2.69530726
92	renal system development (GO:0072001)	2.68572900
93	negative regulation of response to food (GO:0032096)	2.68342334
94	negative regulation of appetite (GO:0032099)	2.68342334
95	cellular protein complex disassembly (GO:0043624)	2.67289815
96	DNA demethylation (GO:0080111)	2.65511657
97	eye photoreceptor cell development (GO:0042462)	2.61490040
98	embryonic epithelial tube formation (GO:0001838)	2.60601571
99	nucleobase catabolic process (GO:0046113)	2.60458800
100	negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)	2.58558864

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	4.53424014
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.31644762
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.29370340
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.64950330
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.60583451
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.46946516
7	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.33799200
8	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.33734940
9	AR_21572438_ChIP-Seq_LNCaP_Human	2.32502929
10	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.31112312
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.24194304
12	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.20907021
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.13057013
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.10212637
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.08432121
16	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.94945377
17	GBX2_23144817_ChIP-Seq_PC3_Human	1.90694889
18	FUS_26573619_Chip-Seq_HEK293_Human	1.90494754
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.88295634
20	MYC_18940864_ChIP-ChIP_HL60_Human	1.87291895
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.85691560
22	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.84631918
23	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.81068570
24	TAF15_26573619_Chip-Seq_HEK293_Human	1.78796327
25	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.78388337
26	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.77378886
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.75225311
28	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.74211525
29	P300_19829295_ChIP-Seq_ESCs_Human	1.69756255
30	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.68028015
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.67784041
32	EWS_26573619_Chip-Seq_HEK293_Human	1.65953466
33	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.65592128
34	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.65247581
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.61907621
36	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.61516281
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.61505728
38	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.60575720
39	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.59794533
40	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.57500765
41	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.57399626
42	ELK1_19687146_ChIP-ChIP_HELA_Human	1.56430150
43	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.54233710
44	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.54222706
45	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.53445655
46	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.49714066
47	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.44486429
48	CBP_20019798_ChIP-Seq_JUKART_Human	1.42784868
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42784868
50	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.41159865
51	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.38664096
52	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.38068644
53	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37581814
54	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.37581814
55	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.37421469
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.35379722
57	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.34206321
58	BCAT_22108803_ChIP-Seq_LS180_Human	1.32027300
59	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.31624551
60	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.30606351
61	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.30603994
62	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.30600632
63	RXR_22108803_ChIP-Seq_LS180_Human	1.29303563
64	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.28251899
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.26629926
66	IRF1_19129219_ChIP-ChIP_H3396_Human	1.25930369
67	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.25767604
68	RNF2_27304074_Chip-Seq_NSC_Mouse	1.25721712
69	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.25306735
70	ERG_20517297_ChIP-Seq_VCAP_Human	1.25248376
71	AR_25329375_ChIP-Seq_VCAP_Human	1.24302961
72	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23014117
73	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.18341934
74	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.17665030
75	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.16990507
76	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.16990507
77	SMAD4_21799915_ChIP-Seq_A2780_Human	1.15752168
78	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.13402961
79	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11551889
80	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.11535034
81	REST_21632747_ChIP-Seq_MESCs_Mouse	1.10827730
82	STAT3_23295773_ChIP-Seq_U87_Human	1.10693151
83	TP53_22573176_ChIP-Seq_HFKS_Human	1.10616480
84	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.09143821
85	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.08619665
86	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.07216645
87	SOX9_26525672_Chip-Seq_HEART_Mouse	1.07163291
88	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.06996523
89	VDR_23849224_ChIP-Seq_CD4+_Human	1.05320807
90	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.04743437
91	TCF4_23295773_ChIP-Seq_U87_Human	1.03905581
92	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.03501952
93	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.02219892
94	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.01983070
95	RUNX2_22187159_ChIP-Seq_PCA_Human	1.01966854
96	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.01923225
97	KDM2B_26808549_Chip-Seq_REH_Human	1.00718240
98	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.98740364
99	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.96476026
100	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.94186333

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	6.66026445
2	MP0008789_abnormal_olfactory_epithelium	5.25800683
3	MP0003787_abnormal_imprinting	4.63486103
4	MP0002938_white_spotting	4.20727145
5	MP0005394_taste/olfaction_phenotype	3.48628209
6	MP0005499_abnormal_olfactory_system	3.48628209
7	MP0008877_abnormal_DNA_methylation	3.01719859
8	MP0002638_abnormal_pupillary_reflex	2.82004276
9	MP0010030_abnormal_orbit_morphology	2.71792219
10	MP0000049_abnormal_middle_ear	2.42919926
11	MP0005503_abnormal_tendon_morphology	2.35809323
12	MP0000566_synostosis	2.34879229
13	MP0005257_abnormal_intraocular_pressure	2.10382429
14	MP0003121_genomic_imprinting	2.08840826
15	MP0009379_abnormal_foot_pigmentation	1.95809401
16	MP0000631_abnormal_neuroendocrine_gland	1.78807800
17	MP0000613_abnormal_salivary_gland	1.78492963
18	MP0002736_abnormal_nociception_after	1.71199863
19	MP0001529_abnormal_vocalization	1.70760999
20	MP0004885_abnormal_endolymph	1.67280050
21	MP0001293_anophthalmia	1.58582879
22	MP0002234_abnormal_pharynx_morphology	1.57964738
23	MP0003011_delayed_dark_adaptation	1.55921483
24	MP0001968_abnormal_touch/_nociception	1.52847793
25	MP0003937_abnormal_limbs/digits/tail_de	1.51636791
26	MP0000778_abnormal_nervous_system	1.46662947
27	MP0005187_abnormal_penis_morphology	1.43278719
28	MP0003122_maternal_imprinting	1.41736784
29	MP0009053_abnormal_anal_canal	1.40133064
30	MP0010307_abnormal_tumor_latency	1.37309396
31	MP0004142_abnormal_muscle_tone	1.37283826
32	MP0000428_abnormal_craniofacial_morphol	1.35617490
33	MP0001485_abnormal_pinna_reflex	1.31029143
34	MP0002837_dystrophic_cardiac_calcinosis	1.29971933
35	MP0005646_abnormal_pituitary_gland	1.29365875
36	MP0003755_abnormal_palate_morphology	1.27100978
37	MP0005171_absent_coat_pigmentation	1.27018615
38	MP0004134_abnormal_chest_morphology	1.25195916
39	MP0002233_abnormal_nose_morphology	1.24148941
40	MP0002277_abnormal_respiratory_mucosa	1.17887417
41	MP0005377_hearing/vestibular/ear_phenot	1.16426937
42	MP0003878_abnormal_ear_physiology	1.16426937
43	MP0003123_paternal_imprinting	1.14977866
44	MP0000372_irregular_coat_pigmentation	1.14837576
45	MP0003938_abnormal_ear_development	1.10029693
46	MP0005551_abnormal_eye_electrophysiolog	1.09331039
47	MP0002160_abnormal_reproductive_system	1.06511580
48	MP0002249_abnormal_larynx_morphology	1.06222253
49	MP0002102_abnormal_ear_morphology	1.02891547
50	MP0004145_abnormal_muscle_electrophysio	1.02500310
51	MP0001299_abnormal_eye_distance/	1.02365249
52	MP0002138_abnormal_hepatobiliary_system	1.01960068
53	MP0002272_abnormal_nervous_system	1.00170552
54	MP0003136_yellow_coat_color	1.00123222
55	MP0002108_abnormal_muscle_morphology	0.97407299
56	MP0000026_abnormal_inner_ear	0.97010783
57	MP0002282_abnormal_trachea_morphology	0.94098247
58	MP0002177_abnormal_outer_ear	0.93775868
59	MP0001286_abnormal_eye_development	0.92780991
60	MP0003942_abnormal_urinary_system	0.92176303
61	MP0000647_abnormal_sebaceous_gland	0.90158505
62	MP0004742_abnormal_vestibular_system	0.88933563
63	MP0002095_abnormal_skin_pigmentation	0.88321070
64	MP0001346_abnormal_lacrimal_gland	0.87729345
65	MP0004133_heterotaxia	0.85978400
66	MP0005391_vision/eye_phenotype	0.85629283
67	MP0000678_abnormal_parathyroid_gland	0.85258752
68	MP0005195_abnormal_posterior_eye	0.83661678
69	MP0003646_muscle_fatigue	0.82944111
70	MP0005253_abnormal_eye_physiology	0.82550047
71	MP0002734_abnormal_mechanical_nocicepti	0.82191822
72	MP0009384_cardiac_valve_regurgitation	0.80584615
73	MP0008872_abnormal_physiological_respon	0.78616600
74	MP0001986_abnormal_taste_sensitivity	0.75072900
75	MP0003936_abnormal_reproductive_system	0.73247957
76	MP0009697_abnormal_copulation	0.72160458
77	MP0005389_reproductive_system_phenotype	0.72119303
78	MP0000569_abnormal_digit_pigmentation	0.71827069
79	MP0002928_abnormal_bile_duct	0.70099664
80	MP0000163_abnormal_cartilage_morphology	0.68965471
81	MP0000762_abnormal_tongue_morphology	0.68556882
82	MP0002116_abnormal_craniofacial_bone	0.68082451
83	MP0002752_abnormal_somatic_nervous	0.67457846
84	MP0002092_abnormal_eye_morphology	0.66023789
85	MP0002109_abnormal_limb_morphology	0.62217980
86	MP0002876_abnormal_thyroid_physiology	0.60996966
87	MP0006072_abnormal_retinal_apoptosis	0.60360331
88	MP0000955_abnormal_spinal_cord	0.59207669
89	MP0002184_abnormal_innervation	0.58497040
90	MP0003119_abnormal_digestive_system	0.58486876
91	MP0004270_analgesia	0.58067265
92	MP0002067_abnormal_sensory_capabilities	0.57818088
93	MP0002735_abnormal_chemical_nociception	0.57279252
94	MP0002163_abnormal_gland_morphology	0.57209035
95	MP0001188_hyperpigmentation	0.57032839
96	MP0003935_abnormal_craniofacial_develop	0.55735405
97	MP0005084_abnormal_gallbladder_morpholo	0.55528115
98	MP0001270_distended_abdomen	0.55390784
99	MP0005386_behavior/neurological_phenoty	0.54889625
100	MP0004924_abnormal_behavior	0.54889625

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Degeneration of the lateral corticospinal tracts (HP:0002314)	5.09781407
2	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	5.09781407
3	Short 4th metacarpal (HP:0010044)	4.96894519
4	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	4.96894519
5	Down-sloping shoulders (HP:0200021)	4.43946739
6	Abnormality of the 4th metacarpal (HP:0010012)	4.18779400
7	Abnormality of the corticospinal tract (HP:0002492)	3.96024058
8	Septo-optic dysplasia (HP:0100842)	3.49810968
9	Hypoplasia of the fovea (HP:0007750)	3.28427671
10	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.28427671
11	Optic nerve hypoplasia (HP:0000609)	3.03149039
12	Termporal pattern (HP:0011008)	3.02240116
13	Insidious onset (HP:0003587)	3.02240116
14	Adrenal hypoplasia (HP:0000835)	2.96524919
15	Abnormal number of incisors (HP:0011064)	2.96119084
16	Bilateral microphthalmos (HP:0007633)	2.95991202
17	Optic nerve coloboma (HP:0000588)	2.95990289
18	Abnormality of the fovea (HP:0000493)	2.89931283
19	Short phalanx of the thumb (HP:0009660)	2.88615276
20	Difficulty running (HP:0009046)	2.82898378
21	Neoplasm of the heart (HP:0100544)	2.81634164
22	Depressed nasal tip (HP:0000437)	2.78952093
23	Abnormality of the aortic arch (HP:0012303)	2.75162913
24	Tented upper lip vermilion (HP:0010804)	2.71998919
25	True hermaphroditism (HP:0010459)	2.67609216
26	Hemivertebrae (HP:0002937)	2.66208488
27	Volvulus (HP:0002580)	2.59571738
28	Genetic anticipation (HP:0003743)	2.55577540
29	Intestinal atresia (HP:0011100)	2.55172835
30	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	2.55031230
31	Palpebral edema (HP:0100540)	2.54900393
32	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.53796681
33	Reticulocytopenia (HP:0001896)	2.53505280
34	Abnormality of the nasal septum (HP:0000419)	2.52745034
35	Abnormality of the diencephalon (HP:0010662)	2.49645988
36	Congenital, generalized hypertrichosis (HP:0004540)	2.49414551
37	Congenital stationary night blindness (HP:0007642)	2.46606649
38	Large earlobe (HP:0009748)	2.45244036
39	Acute necrotizing encephalopathy (HP:0006965)	2.40430261
40	Oligodactyly (HP:0012165)	2.31962111
41	Decreased subcutaneous fat (HP:0001002)	2.28887516
42	Abnormality of the carotid arteries (HP:0005344)	2.27297558
43	Chorioretinal atrophy (HP:0000533)	2.25883487
44	Pancreatic cysts (HP:0001737)	2.25421811
45	Midline defect of the nose (HP:0004122)	2.25176199
46	Anophthalmia (HP:0000528)	2.21631213
47	Esophageal atresia (HP:0002032)	2.18997244
48	Thickened helices (HP:0000391)	2.18394230
49	Chromsome breakage (HP:0040012)	2.18283921
50	Woolly hair (HP:0002224)	2.16455751
51	Broad alveolar ridges (HP:0000187)	2.15858565
52	Hyperventilation (HP:0002883)	2.15257529
53	Abnormality of midbrain morphology (HP:0002418)	2.11111951
54	Molar tooth sign on MRI (HP:0002419)	2.11111951
55	High anterior hairline (HP:0009890)	2.10930096
56	Nonprogressive disorder (HP:0003680)	2.09117031
57	Oligodactyly (hands) (HP:0001180)	2.08741972
58	Urinary bladder sphincter dysfunction (HP:0002839)	2.08163750
59	Abnormality of the parietal bone (HP:0002696)	2.07868364
60	Pancreatic fibrosis (HP:0100732)	2.07114855
61	Abnormality of cells of the erythroid lineage (HP:0012130)	2.06161912
62	Progressive macrocephaly (HP:0004481)	2.05622973
63	Abnormal mitochondria in muscle tissue (HP:0008316)	2.04698720
64	Sclerocornea (HP:0000647)	2.03865825
65	Median cleft lip (HP:0000161)	2.03483139
66	Focal motor seizures (HP:0011153)	2.02851143
67	Hyperalaninemia (HP:0003348)	2.02247926
68	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.02247926
69	Abnormality of alanine metabolism (HP:0010916)	2.02247926
70	Growth hormone deficiency (HP:0000824)	2.01791248
71	Medial flaring of the eyebrow (HP:0010747)	2.00851890
72	Acute encephalopathy (HP:0006846)	2.00584646
73	Trigonocephaly (HP:0000243)	2.00559446
74	Abnormality of the metopic suture (HP:0005556)	1.99374770
75	Mask-like facies (HP:0000298)	1.97450118
76	Rib fusion (HP:0000902)	1.95845999
77	Redundant skin (HP:0001582)	1.93221979
78	Gastrointestinal atresia (HP:0002589)	1.91941504
79	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.90443798
80	Medulloblastoma (HP:0002885)	1.89509268
81	Meningioma (HP:0002858)	1.88470486
82	Abnormality of the incisor (HP:0000676)	1.88272348
83	Supernumerary ribs (HP:0005815)	1.88157830
84	Impaired vibration sensation in the lower limbs (HP:0002166)	1.87858931
85	Supernumerary bones of the axial skeleton (HP:0009144)	1.86894823
86	Milia (HP:0001056)	1.85130400
87	Shawl scrotum (HP:0000049)	1.85012834
88	Agitation (HP:0000713)	1.84176402
89	Oral leukoplakia (HP:0002745)	1.82482431
90	Holoprosencephaly (HP:0001360)	1.81445394
91	Morphological abnormality of the pyramidal tract (HP:0002062)	1.80015948
92	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.78081312
93	Mitochondrial inheritance (HP:0001427)	1.77329840
94	Short thumb (HP:0009778)	1.76165215
95	Gait imbalance (HP:0002141)	1.75687663
96	Pendular nystagmus (HP:0012043)	1.74981185
97	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.74384226
98	Nephronophthisis (HP:0000090)	1.71499039
99	Aplasia/Hypoplasia of the macula (HP:0008059)	1.70867489
100	Neoplasm of striated muscle (HP:0009728)	1.70690667

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA3	5.23949496
2	EPHB2	4.11517251
3	NUAK1	3.36932181
4	CASK	3.04398685
5	BCKDK	2.71215905
6	MAPK13	2.57220805
7	ADRBK2	2.42464717
8	MAP4K2	2.27238279
9	LATS1	2.17803404
10	TIE1	2.05822951
11	NLK	2.04029081
12	DYRK2	2.03882471
13	PLK4	2.03384415
14	IRAK1	1.75821340
15	PLK2	1.71130204
16	SGK2	1.65566606
17	FRK	1.65153119
18	MKNK2	1.60102515
19	CDK3	1.53951390
20	WNK3	1.52322759
21	PIK3CA	1.49307193
22	GRK1	1.48676463
23	HIPK2	1.45554512
24	PHKG2	1.45440154
25	PHKG1	1.45440154
26	CDC7	1.40254435
27	TSSK6	1.39293457
28	MARK1	1.32897974
29	SGK494	1.27545886
30	SGK223	1.27545886
31	CAMKK2	1.26619176
32	PTK2B	1.21728055
33	TLK1	1.19356587
34	CAMK1G	1.14457707
35	IRAK2	1.13149476
36	CAMK1D	1.12321494
37	PNCK	1.11159690
38	WNK4	1.09577273
39	CSNK1G1	1.09373305
40	INSRR	1.05780888
41	NME2	0.95145226
42	OBSCN	0.90137654
43	MAP2K7	0.90050116
44	TNK2	0.87737126
45	VRK2	0.87608243
46	VRK1	0.87160439
47	MAP3K4	0.86478304
48	DMPK	0.86187024
49	SGK3	0.79824264
50	GRK5	0.79281648
51	RPS6KA5	0.79047562
52	MAPK7	0.73905955
53	MKNK1	0.72850489
54	GSK3A	0.70202017
55	STK39	0.69595942
56	CSNK1G2	0.64170346
57	LIMK1	0.63186726
58	ADRBK1	0.62356174
59	YES1	0.61723825
60	IKBKE	0.60294510
61	STK16	0.56667472
62	CDK19	0.55728043
63	PINK1	0.55531353
64	CSNK1A1	0.54548567
65	PRKD3	0.54390789
66	PRKCH	0.53858907
67	TGFBR2	0.53003804
68	TXK	0.51976537
69	PRKCE	0.49498817
70	BMPR1B	0.48671602
71	PRKCG	0.47949553
72	PRKG1	0.47728723
73	CAMK1	0.46692946
74	ERBB4	0.46544881
75	AURKA	0.45161034
76	TAOK3	0.43379403
77	WEE1	0.42449462
78	MAP3K6	0.38858533
79	ATR	0.38306757
80	PRKACA	0.37415409
81	PLK1	0.37374999
82	STK3	0.36990300
83	PBK	0.36714783
84	NEK1	0.36513516
85	MUSK	0.35439885
86	ZAK	0.35343803
87	SGK1	0.34882888
88	NTRK3	0.34072568
89	NME1	0.32989391
90	DYRK1A	0.32620779
91	ILK	0.31705494
92	CAMK2A	0.31449127
93	PRKCI	0.30610681
94	OXSR1	0.30463497
95	CHEK2	0.28477360
96	CSNK2A2	0.28463125
97	CAMK2G	0.27271525
98	STK38L	0.26298380
99	CDK4	0.26261541
100	DAPK2	0.25836569

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.64061465
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.32579752
3	RNA polymerase_Homo sapiens_hsa03020	2.64859862
4	Parkinsons disease_Homo sapiens_hsa05012	2.59632740
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.54059504
6	Basal cell carcinoma_Homo sapiens_hsa05217	2.40813248
7	Cardiac muscle contraction_Homo sapiens_hsa04260	2.26465561
8	Phototransduction_Homo sapiens_hsa04744	2.24879463
9	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.23963245
10	Huntingtons disease_Homo sapiens_hsa05016	2.12095500
11	Proteasome_Homo sapiens_hsa03050	2.09769001
12	Nitrogen metabolism_Homo sapiens_hsa00910	2.04352661
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.03103863
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.00789921
15	Homologous recombination_Homo sapiens_hsa03440	1.84834023
16	Alzheimers disease_Homo sapiens_hsa05010	1.82449379
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.73556135
18	RNA degradation_Homo sapiens_hsa03018	1.70794175
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.68643611
20	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.67484039
21	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.64673037
22	Basal transcription factors_Homo sapiens_hsa03022	1.62030037
23	Steroid biosynthesis_Homo sapiens_hsa00100	1.43643946
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.42629479
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.37476498
26	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.35404788
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.31528965
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.30709327
29	Ether lipid metabolism_Homo sapiens_hsa00565	1.28133756
30	Nicotine addiction_Homo sapiens_hsa05033	1.28080893
31	Protein export_Homo sapiens_hsa03060	1.24421097
32	Insulin secretion_Homo sapiens_hsa04911	1.23763879
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.23495498
34	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.16946193
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.16460637
36	Asthma_Homo sapiens_hsa05310	1.14027507
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.02261691
38	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.00908310
39	Sulfur relay system_Homo sapiens_hsa04122	0.99377468
40	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.98798721
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.96278617
42	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.95487423
43	Nucleotide excision repair_Homo sapiens_hsa03420	0.92518012
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.92001602
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.89547275
46	Peroxisome_Homo sapiens_hsa04146	0.89217592
47	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.88448743
48	Chemical carcinogenesis_Homo sapiens_hsa05204	0.86350808
49	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.85326183
50	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.84147220
51	Pyruvate metabolism_Homo sapiens_hsa00620	0.83833234
52	Mineral absorption_Homo sapiens_hsa04978	0.83268553
53	RNA transport_Homo sapiens_hsa03013	0.83216322
54	Axon guidance_Homo sapiens_hsa04360	0.82685692
55	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.82411148
56	Base excision repair_Homo sapiens_hsa03410	0.82308805
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.78132788
58	Butanoate metabolism_Homo sapiens_hsa00650	0.77313558
59	Propanoate metabolism_Homo sapiens_hsa00640	0.71713873
60	Circadian entrainment_Homo sapiens_hsa04713	0.71447180
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69941428
62	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.67342188
63	Wnt signaling pathway_Homo sapiens_hsa04310	0.66592261
64	Salivary secretion_Homo sapiens_hsa04970	0.65150225
65	Regulation of autophagy_Homo sapiens_hsa04140	0.63426496
66	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.60972323
67	Purine metabolism_Homo sapiens_hsa00230	0.60846175
68	Glutathione metabolism_Homo sapiens_hsa00480	0.60617631
69	Retinol metabolism_Homo sapiens_hsa00830	0.58562205
70	Cocaine addiction_Homo sapiens_hsa05030	0.58051169
71	cAMP signaling pathway_Homo sapiens_hsa04024	0.58002004
72	Histidine metabolism_Homo sapiens_hsa00340	0.56145570
73	Serotonergic synapse_Homo sapiens_hsa04726	0.55983008
74	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.55842486
75	Metabolic pathways_Homo sapiens_hsa01100	0.55768149
76	Olfactory transduction_Homo sapiens_hsa04740	0.54154460
77	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.52529847
78	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.52252192
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.49740515
80	Calcium signaling pathway_Homo sapiens_hsa04020	0.49267178
81	Fat digestion and absorption_Homo sapiens_hsa04975	0.48741096
82	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.48513507
83	Morphine addiction_Homo sapiens_hsa05032	0.47098694
84	Hippo signaling pathway_Homo sapiens_hsa04390	0.45261983
85	Tryptophan metabolism_Homo sapiens_hsa00380	0.45193497
86	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.44060531
87	Allograft rejection_Homo sapiens_hsa05330	0.41084875
88	Amphetamine addiction_Homo sapiens_hsa05031	0.40718712
89	Mismatch repair_Homo sapiens_hsa03430	0.39696160
90	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.39549990
91	Bile secretion_Homo sapiens_hsa04976	0.39513247
92	Dopaminergic synapse_Homo sapiens_hsa04728	0.37959366
93	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.37420917
94	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.36647882
95	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.34760512
96	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.34474062
97	Spliceosome_Homo sapiens_hsa03040	0.34346246
98	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.33486523
99	Fatty acid metabolism_Homo sapiens_hsa01212	0.33216781
100	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.29700902

RPL30P14

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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