RPL30P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1striated muscle atrophy (GO:0014891)9.86151693
2skeletal muscle adaptation (GO:0043501)9.85577939
3muscle atrophy (GO:0014889)9.33397201
4response to gravity (GO:0009629)9.17364110
5negative regulation of muscle hypertrophy (GO:0014741)7.34353805
6skeletal muscle tissue regeneration (GO:0043403)6.83143050
7muscle filament sliding (GO:0030049)6.53143370
8actin-myosin filament sliding (GO:0033275)6.53143370
9regulation of skeletal muscle contraction (GO:0014819)6.11147226
10response to muscle activity (GO:0014850)5.90667436
11negative regulation of skeletal muscle tissue development (GO:0048642)5.70368744
12actin-mediated cell contraction (GO:0070252)5.64121387
13cellular response to dexamethasone stimulus (GO:0071549)4.75179470
14platelet dense granule organization (GO:0060155)4.72555978
15response to activity (GO:0014823)4.63839153
16appendage development (GO:0048736)4.57676688
17limb development (GO:0060173)4.57676688
18response to dexamethasone (GO:0071548)4.38854571
19substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.35161716
20substrate-independent telencephalic tangential migration (GO:0021826)4.35161716
21actin filament-based movement (GO:0030048)4.32892917
22striated muscle adaptation (GO:0014888)4.28198424
23dendritic spine morphogenesis (GO:0060997)4.15034616
24protein K6-linked ubiquitination (GO:0085020)4.02079348
25nonmotile primary cilium assembly (GO:0035058)3.93155713
26secretory granule organization (GO:0033363)3.91116357
27cullin deneddylation (GO:0010388)3.87740637
28positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.85748553
29positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.85748553
30positive regulation of mitotic sister chromatid separation (GO:1901970)3.85748553
31histone mRNA catabolic process (GO:0071044)3.70357987
32intraciliary transport (GO:0042073)3.58451534
33muscle adaptation (GO:0043500)3.46701585
34anterograde synaptic vesicle transport (GO:0048490)3.41332391
35regulation of B cell receptor signaling pathway (GO:0050855)3.39551754
36behavioral response to nicotine (GO:0035095)3.36752122
37regulation of muscle hypertrophy (GO:0014743)3.35299585
38cellular response to glucocorticoid stimulus (GO:0071385)3.32126223
39muscle organ development (GO:0007517)3.31866370
40response to electrical stimulus (GO:0051602)3.29021954
41pantothenate metabolic process (GO:0015939)3.24651667
42negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.23365406
43chaperone-mediated protein complex assembly (GO:0051131)3.22825470
44muscle structure development (GO:0061061)3.22578479
45positive regulation of gastrulation (GO:2000543)3.17901467
46biotin metabolic process (GO:0006768)3.14711493
47mature B cell differentiation (GO:0002335)3.14412575
48retinal ganglion cell axon guidance (GO:0031290)3.14208331
49protein deneddylation (GO:0000338)3.10107122
50nucleobase catabolic process (GO:0046113)3.08413623
51dosage compensation (GO:0007549)3.00587800
52regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.97276493
53DNA demethylation (GO:0080111)2.97138246
54cellular response to corticosteroid stimulus (GO:0071384)2.96584606
55central nervous system projection neuron axonogenesis (GO:0021952)2.96402888
56protein localization to chromosome, centromeric region (GO:0071459)2.92675140
57negative regulation of cAMP-mediated signaling (GO:0043951)2.92063111
58protein localization to microtubule cytoskeleton (GO:0072698)2.92051493
59negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.88198229
60negative regulation of translation, ncRNA-mediated (GO:0040033)2.88198229
61regulation of translation, ncRNA-mediated (GO:0045974)2.88198229
62regulation of centriole replication (GO:0046599)2.87439537
63regulation of receptor binding (GO:1900120)2.87420898
64radial glial cell differentiation (GO:0060019)2.87265996
65positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.86209320
66branched-chain amino acid catabolic process (GO:0009083)2.84230060
67skeletal muscle contraction (GO:0003009)2.84042676
68regulation of action potential (GO:0098900)2.79153452
69positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.78207909
70DNA dealkylation (GO:0035510)2.77194359
71protein localization to kinetochore (GO:0034501)2.73116131
72tissue regeneration (GO:0042246)2.71606964
73cytidine metabolic process (GO:0046087)2.70744479
74cytidine catabolic process (GO:0006216)2.70744479
75cytidine deamination (GO:0009972)2.70744479
76mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.69581106
77positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.69581106
78metaphase plate congression (GO:0051310)2.68847645
79ncRNA catabolic process (GO:0034661)2.63555738
80olfactory bulb development (GO:0021772)2.63373875
81exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.63272184
82cranial nerve morphogenesis (GO:0021602)2.61900054
83response to inactivity (GO:0014854)2.61295902
84dentate gyrus development (GO:0021542)2.61060103
85response to folic acid (GO:0051593)2.60866416
86positive regulation of sodium ion transmembrane transport (GO:1902307)2.58505256
87negative regulation of mast cell activation (GO:0033004)2.55916370
88nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.54386412
89protein localization to cilium (GO:0061512)2.54363579
90melanosome organization (GO:0032438)2.52912076
91neurotransmitter catabolic process (GO:0042135)2.52132114
92central nervous system neuron axonogenesis (GO:0021955)2.51797512
93muscle organ morphogenesis (GO:0048644)2.49485587
94cellular ketone body metabolic process (GO:0046950)2.47926471
95negative regulation of organelle assembly (GO:1902116)2.46364139
96cardiac ventricle formation (GO:0003211)2.45183415
97insulin secretion (GO:0030073)2.44268026
98glial cell proliferation (GO:0014009)2.44224627
99neurotransmitter biosynthetic process (GO:0042136)2.42368041
100gamma-aminobutyric acid signaling pathway (GO:0007214)2.41985371

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.69847753
2VDR_22108803_ChIP-Seq_LS180_Human5.22596266
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.75193128
4IGF1R_20145208_ChIP-Seq_DFB_Human2.87010881
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.83074221
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.79917689
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.78306653
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68779428
9TAF15_26573619_Chip-Seq_HEK293_Human2.61896350
10AR_21572438_ChIP-Seq_LNCaP_Human2.57769223
11FUS_26573619_Chip-Seq_HEK293_Human2.53096352
12GBX2_23144817_ChIP-Seq_PC3_Human2.42090009
13EZH2_22144423_ChIP-Seq_EOC_Human2.38173484
14CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.04091831
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.00089793
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98692994
17SMAD4_21799915_ChIP-Seq_A2780_Human1.95164216
18PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.94806964
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92724244
20ZNF274_21170338_ChIP-Seq_K562_Hela1.91940500
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.88631815
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87581235
23EWS_26573619_Chip-Seq_HEK293_Human1.85366006
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.82627051
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79195556
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78112541
27ER_23166858_ChIP-Seq_MCF-7_Human1.76315651
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.72150107
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.72021358
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65617717
31P300_19829295_ChIP-Seq_ESCs_Human1.58285877
32STAT3_23295773_ChIP-Seq_U87_Human1.57261486
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56392230
34CBP_20019798_ChIP-Seq_JUKART_Human1.53301097
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53301097
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52087875
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52087875
38TCF4_23295773_ChIP-Seq_U87_Human1.50402730
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50287860
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49365168
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.48631178
42RXR_22108803_ChIP-Seq_LS180_Human1.47072741
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45980199
44ELK1_19687146_ChIP-ChIP_HELA_Human1.45773697
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41573482
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40375676
47GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.38183247
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37673012
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36828133
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.32915803
51EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32776155
52FLI1_21867929_ChIP-Seq_TH2_Mouse1.28437688
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28366780
54AR_25329375_ChIP-Seq_VCAP_Human1.26985376
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.26865349
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26288338
57BCAT_22108803_ChIP-Seq_LS180_Human1.25989755
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25556076
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24222980
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21645206
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21466548
62RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20282545
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20101627
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19313522
65TAL1_26923725_Chip-Seq_HPCs_Mouse1.19283556
66TP53_22573176_ChIP-Seq_HFKS_Human1.18594563
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18075567
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17699761
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16948636
70CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13715626
71AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13368617
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12336944
73RUNX2_22187159_ChIP-Seq_PCA_Human1.11554249
74TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10902699
75KDM2B_26808549_Chip-Seq_REH_Human1.10754632
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07556416
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.07211410
78KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06612129
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.05574289
80EED_16625203_ChIP-ChIP_MESCs_Mouse1.05142782
81SALL4_22934838_ChIP-ChIP_CD34+_Human1.04557107
82VDR_23849224_ChIP-Seq_CD4+_Human1.03301819
83RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99863860
84SMAD_19615063_ChIP-ChIP_OVARY_Human0.99145627
85FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.98243968
86SOX2_21211035_ChIP-Seq_LN229_Gbm0.98076927
87E2F1_18555785_Chip-Seq_ESCs_Mouse0.97118383
88NFE2_27457419_Chip-Seq_LIVER_Mouse0.96785812
89JARID2_20064375_ChIP-Seq_MESCs_Mouse0.96345236
90CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95997999
91CRX_20693478_ChIP-Seq_RETINA_Mouse0.95808889
92KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95560642
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94180069
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93936389
95EZH2_27294783_Chip-Seq_NPCs_Mouse0.92249401
96P53_22387025_ChIP-Seq_ESCs_Mouse0.91884119
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91178932
98SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91129193
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90342139
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88284750

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation8.08426393
2MP0003787_abnormal_imprinting4.74634297
3MP0002638_abnormal_pupillary_reflex4.57327333
4MP0004145_abnormal_muscle_electrophysio4.43465669
5MP0000747_muscle_weakness3.21267293
6MP0005171_absent_coat_pigmentation2.87459563
7MP0000749_muscle_degeneration2.83549471
8MP0002822_catalepsy2.54333114
9MP0005174_abnormal_tail_pigmentation2.37217646
10MP0002269_muscular_atrophy2.35285834
11MP0006276_abnormal_autonomic_nervous2.31096553
12MP0010234_abnormal_vibrissa_follicle2.25888900
13MP0003121_genomic_imprinting2.20675743
14MP0004036_abnormal_muscle_relaxation2.10555834
15MP0002089_abnormal_postnatal_growth/wei2.09919972
16MP0008789_abnormal_olfactory_epithelium2.08456006
17MP0005499_abnormal_olfactory_system2.01241985
18MP0005394_taste/olfaction_phenotype2.01241985
19MP0002095_abnormal_skin_pigmentation1.88317493
20MP0008877_abnormal_DNA_methylation1.86953286
21MP0000759_abnormal_skeletal_muscle1.85677164
22MP0004270_analgesia1.61251430
23MP0004087_abnormal_muscle_fiber1.54403171
24MP0005620_abnormal_muscle_contractility1.53625779
25MP0000778_abnormal_nervous_system1.51961825
26MP0000013_abnormal_adipose_tissue1.51214463
27MP0000427_abnormal_hair_cycle1.50524382
28MP0002102_abnormal_ear_morphology1.43069946
29MP0000371_diluted_coat_color1.40241093
30MP0002106_abnormal_muscle_physiology1.37217958
31MP0000015_abnormal_ear_pigmentation1.35372464
32MP0002108_abnormal_muscle_morphology1.34678477
33MP0000372_irregular_coat_pigmentation1.29378679
34MP0002177_abnormal_outer_ear1.26676361
35MP0002009_preneoplasia1.26078612
36MP0003122_maternal_imprinting1.19567886
37MP0006072_abnormal_retinal_apoptosis1.18932658
38MP0002928_abnormal_bile_duct1.18172293
39MP0001984_abnormal_olfaction1.15911712
40MP0005167_abnormal_blood-brain_barrier1.14945148
41MP0008995_early_reproductive_senescence1.12902648
42MP0002938_white_spotting1.12625760
43MP0005408_hypopigmentation1.11023249
44MP0004134_abnormal_chest_morphology1.09217339
45MP0005075_abnormal_melanosome_morpholog1.08991066
46MP0008057_abnormal_DNA_replication1.06722077
47MP0005083_abnormal_biliary_tract1.04565285
48MP0004215_abnormal_myocardial_fiber1.04076942
49MP0001661_extended_life_span1.03536453
50MP0005645_abnormal_hypothalamus_physiol0.99785948
51MP0005386_behavior/neurological_phenoty0.99773125
52MP0004924_abnormal_behavior0.99773125
53MP0005369_muscle_phenotype0.97950840
54MP0000733_abnormal_muscle_development0.96769632
55MP0008058_abnormal_DNA_repair0.94546082
56MP0000751_myopathy0.92026542
57MP0001293_anophthalmia0.91864003
58MP0005551_abnormal_eye_electrophysiolog0.91764627
59MP0002166_altered_tumor_susceptibility0.91637368
60MP0003705_abnormal_hypodermis_morpholog0.91598313
61MP0003959_abnormal_lean_body0.89871747
62MP0003786_premature_aging0.86961934
63MP0002971_abnormal_brown_adipose0.86220827
64MP0005253_abnormal_eye_physiology0.86061179
65MP0000631_abnormal_neuroendocrine_gland0.85683794
66MP0002075_abnormal_coat/hair_pigmentati0.85561370
67MP0002877_abnormal_melanocyte_morpholog0.81657943
68MP0003937_abnormal_limbs/digits/tail_de0.81545101
69MP0005670_abnormal_white_adipose0.80369958
70MP0001186_pigmentation_phenotype0.78748372
71MP0002127_abnormal_cardiovascular_syste0.76855337
72MP0002751_abnormal_autonomic_nervous0.75967710
73MP0001324_abnormal_eye_pigmentation0.74275771
74MP0002896_abnormal_bone_mineralization0.74023388
75MP0000516_abnormal_urinary_system0.72819102
76MP0005367_renal/urinary_system_phenotyp0.72819102
77MP0000955_abnormal_spinal_cord0.71597681
78MP0002233_abnormal_nose_morphology0.70776227
79MP0002277_abnormal_respiratory_mucosa0.68574422
80MP0005248_abnormal_Harderian_gland0.68098547
81MP0006036_abnormal_mitochondrial_physio0.66474091
82MP0003755_abnormal_palate_morphology0.64523261
83MP0009046_muscle_twitch0.63208340
84MP0004484_altered_response_of0.62724560
85MP0006292_abnormal_olfactory_placode0.61344107
86MP0002332_abnormal_exercise_endurance0.60147094
87MP0005391_vision/eye_phenotype0.58921104
88MP0008872_abnormal_physiological_respon0.58914532
89MP0010386_abnormal_urinary_bladder0.57383129
90MP0003221_abnormal_cardiomyocyte_apopto0.57251172
91MP0002006_tumorigenesis0.57093418
92MP0000049_abnormal_middle_ear0.56108693
93MP0001440_abnormal_grooming_behavior0.55935816
94MP0001502_abnormal_circadian_rhythm0.54776031
95MP0000750_abnormal_muscle_regeneration0.54595571
96MP0002114_abnormal_axial_skeleton0.52908232
97MP0000003_abnormal_adipose_tissue0.52819105
98MP0002092_abnormal_eye_morphology0.51968010
99MP0002272_abnormal_nervous_system0.51731966
100MP0004811_abnormal_neuron_physiology0.51551941

Predicted human phenotypes

RankGene SetZ-score
1Palpebral edema (HP:0100540)6.84332232
2Distal arthrogryposis (HP:0005684)4.79305919
3Nemaline bodies (HP:0003798)4.33220641
4Mask-like facies (HP:0000298)4.15626096
5Medial flaring of the eyebrow (HP:0010747)4.12182093
6Round ear (HP:0100830)4.12026922
7Congenital primary aphakia (HP:0007707)3.77867784
8Exercise-induced myalgia (HP:0003738)3.72718040
9Absent phalangeal crease (HP:0006109)3.70744051
10Gait imbalance (HP:0002141)3.70256472
11Hyperkalemia (HP:0002153)3.69749767
12Calcaneovalgus deformity (HP:0001848)3.46632448
13Muscle fiber inclusion bodies (HP:0100299)3.44676241
14Poor coordination (HP:0002370)3.40050871
15Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.38637597
16Abnormality of the labia minora (HP:0012880)3.35950486
17Progressive cerebellar ataxia (HP:0002073)3.34702590
18Nephrogenic diabetes insipidus (HP:0009806)3.32021306
19Exercise-induced muscle cramps (HP:0003710)3.31806728
20Ulnar deviation of the wrist (HP:0003049)3.30794373
21Abnormal finger flexion creases (HP:0006143)3.17140009
22Tubulointerstitial nephritis (HP:0001970)3.15784313
23Myoglobinuria (HP:0002913)3.11016768
24Albinism (HP:0001022)3.10706566
25Periorbital edema (HP:0100539)3.05109136
26Deformed tarsal bones (HP:0008119)2.98058693
27Difficulty running (HP:0009046)2.90556041
28Increased serum pyruvate (HP:0003542)2.88284531
29Facial edema (HP:0000282)2.87859521
30Menstrual irregularities (HP:0000858)2.84894879
31Oligodactyly (hands) (HP:0001180)2.84495905
32Nephronophthisis (HP:0000090)2.80615545
33Myopathic facies (HP:0002058)2.78324756
34Thyroiditis (HP:0100646)2.73357627
35Oligomenorrhea (HP:0000876)2.67418487
36Generalized hypopigmentation (HP:0007513)2.65360583
37Hepatoblastoma (HP:0002884)2.64482984
38Intestinal atresia (HP:0011100)2.63236635
39Volvulus (HP:0002580)2.60272258
40Abnormality of the renal medulla (HP:0100957)2.57544471
41Renal cortical cysts (HP:0000803)2.50627822
42Abnormality of glycolysis (HP:0004366)2.46888780
43Gaze-evoked nystagmus (HP:0000640)2.41962479
44Abnormality of midbrain morphology (HP:0002418)2.34600008
45Molar tooth sign on MRI (HP:0002419)2.34600008
46Genital tract atresia (HP:0001827)2.31298077
473-Methylglutaconic aciduria (HP:0003535)2.30622226
48Vaginal atresia (HP:0000148)2.29453160
49Increased connective tissue (HP:0009025)2.28169237
50Type 1 muscle fiber predominance (HP:0003803)2.26743453
51Partial agenesis of the corpus callosum (HP:0001338)2.24034108
52Abnormality of macular pigmentation (HP:0008002)2.20136411
53Aplasia/Hypoplasia of the lens (HP:0008063)2.19804152
54Dysdiadochokinesis (HP:0002075)2.17541573
55Gonadotropin excess (HP:0000837)2.16427149
56Abnormality of potassium homeostasis (HP:0011042)2.15606703
57Hypoplastic ischia (HP:0003175)2.13578429
58Specific learning disability (HP:0001328)2.10251386
59Myotonia (HP:0002486)2.09059781
60Abnormality of the renal cortex (HP:0011035)2.08364190
61Abnormality of the fovea (HP:0000493)2.08180406
62Long clavicles (HP:0000890)2.08018206
63Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.06953865
64Congenital stationary night blindness (HP:0007642)2.06838172
65Methylmalonic acidemia (HP:0002912)2.04875628
66Short foot (HP:0001773)2.04848414
67Fair hair (HP:0002286)2.03540155
68Neoplasm of the heart (HP:0100544)1.95537922
69Protruding tongue (HP:0010808)1.93309184
70Generalized hypopigmentation of hair (HP:0011358)1.93212586
71Genetic anticipation (HP:0003743)1.91144127
72Wrist flexion contracture (HP:0001239)1.88027747
73Agitation (HP:0000713)1.87325898
74Small hand (HP:0200055)1.87226299
75Broad foot (HP:0001769)1.86541404
76Progressive macrocephaly (HP:0004481)1.84443400
77Increased CSF lactate (HP:0002490)1.83531186
78Hypochromic microcytic anemia (HP:0004840)1.82739486
79Ventricular fibrillation (HP:0001663)1.82626052
80Hip dysplasia (HP:0001385)1.82270864
81Labial hypoplasia (HP:0000066)1.79878494
82Down-sloping shoulders (HP:0200021)1.79461864
83Left ventricular hypertrophy (HP:0001712)1.78728398
84Choroideremia (HP:0001139)1.77018104
85Iris hypopigmentation (HP:0007730)1.76656867
86Bell-shaped thorax (HP:0001591)1.76620736
87Broad-based gait (HP:0002136)1.75070320
88Hypoplastic iliac wings (HP:0002866)1.72887993
89Aplasia/Hypoplasia of the fovea (HP:0008060)1.72192384
90Hypoplasia of the fovea (HP:0007750)1.72192384
91Acute necrotizing encephalopathy (HP:0006965)1.71768095
92Facial diplegia (HP:0001349)1.70954495
93Neonatal respiratory distress (HP:0002643)1.69786856
94Submucous cleft hard palate (HP:0000176)1.69686621
95Thyroid-stimulating hormone excess (HP:0002925)1.67436114
96Abnormality of the ischium (HP:0003174)1.67423908
97Medulloblastoma (HP:0002885)1.67353875
98Narrow forehead (HP:0000341)1.66821721
99Impulsivity (HP:0100710)1.66471868
100Decreased circulating renin level (HP:0003351)1.65801074

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.63235400
2EPHA33.12600527
3FRK2.91950394
4CAMKK22.85714627
5OBSCN2.84419673
6NUAK12.72451552
7PHKG12.55004165
8PHKG22.55004165
9MAP3K102.24237645
10TRIM282.19808852
11DMPK2.13544492
12AKT32.03148854
13TIE12.02432960
14SGK22.01970526
15STK161.93021663
16FGFR21.90751298
17EPHB11.90052985
18BRSK21.86689413
19MARK31.77404604
20SIK31.76673101
21PDK21.74554178
22MAP3K41.59872287
23CCNB11.54420105
24BCKDK1.49938771
25CAMK1G1.48884520
26SGK4941.45787009
27SGK2231.45787009
28MAP2K71.41613535
29IRAK11.30733583
30CAMK1D1.29850806
31TYRO31.27291011
32MAP4K21.26683593
33MST41.19210671
34RAF11.10516193
35SGK31.09269820
36PKN21.07948054
37DYRK31.05080526
38BRD41.01783853
39TAOK10.97761498
40FGFR30.97324637
41GRK10.95842453
42WNK40.94722457
43CAMKK10.94480256
44PINK10.92338968
45PIK3CA0.91750838
46WNK10.91397378
47FGFR10.87334205
48MAPK130.86258975
49ACVR1B0.85558092
50PRKG10.83873874
51VRK10.83477098
52STK110.83154581
53CHEK20.79273343
54TEC0.77928572
55SRPK10.75988041
56MAP3K60.75332151
57CAMK10.75025750
58LIMK10.73293735
59BCR0.69966751
60MARK20.68743396
61ILK0.66743463
62CHUK0.66245768
63ERBB30.65616705
64NTRK30.65581272
65CASK0.65566066
66MAP3K140.65490489
67BMPR1B0.64605199
68CAMK40.61587382
69DAPK20.61493201
70OXSR10.61223596
71PIK3CG0.56813244
72MAP2K40.56777675
73NLK0.56551700
74BRSK10.54672053
75TAF10.53048566
76EIF2AK30.52729868
77RPS6KA40.50820168
78CDK30.49307923
79PIM10.49256992
80MARK10.48919878
81PRKAA10.46878533
82ATR0.45248322
83CDK90.43494280
84DYRK1B0.43454560
85JAK30.43425357
86PLK30.41408815
87BMPR20.40098934
88ATM0.39136447
89PRKACB0.38372623
90FER0.35286165
91PRKCE0.35044132
92CAMK2G0.34957054
93SGK10.34357866
94PRKACA0.33066834
95CSNK1G10.32813276
96CDK40.31828301
97TESK10.29555002
98CSNK1A1L0.28833916
99NTRK20.28604540
100PASK0.27751519

Predicted pathways (KEGG)

RankGene SetZ-score
1Regulation of autophagy_Homo sapiens_hsa041405.53227455
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.82465360
3RNA degradation_Homo sapiens_hsa030182.77403674
4Tight junction_Homo sapiens_hsa045302.63061263
5Protein export_Homo sapiens_hsa030602.57640922
6Circadian rhythm_Homo sapiens_hsa047102.55704059
7Butanoate metabolism_Homo sapiens_hsa006502.31884482
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.22455611
9Vitamin B6 metabolism_Homo sapiens_hsa007502.10990323
10Caffeine metabolism_Homo sapiens_hsa002321.97267472
11Propanoate metabolism_Homo sapiens_hsa006401.89064699
12Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.74942346
13Linoleic acid metabolism_Homo sapiens_hsa005911.72917540
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.58874778
15Oxytocin signaling pathway_Homo sapiens_hsa049211.52576365
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45903299
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42160317
18Basal transcription factors_Homo sapiens_hsa030221.41788551
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41656655
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41129151
21Proteasome_Homo sapiens_hsa030501.39246785
22cGMP-PKG signaling pathway_Homo sapiens_hsa040221.37399499
23Insulin secretion_Homo sapiens_hsa049111.32475015
24Vascular smooth muscle contraction_Homo sapiens_hsa042701.32256684
25Renin secretion_Homo sapiens_hsa049241.29631837
26Fat digestion and absorption_Homo sapiens_hsa049751.29049722
27Huntingtons disease_Homo sapiens_hsa050161.28123336
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.23334818
29Circadian entrainment_Homo sapiens_hsa047131.17627010
30Wnt signaling pathway_Homo sapiens_hsa043101.17499211
31Nicotine addiction_Homo sapiens_hsa050331.13848006
32Fanconi anemia pathway_Homo sapiens_hsa034601.12957860
33Glucagon signaling pathway_Homo sapiens_hsa049221.11884664
34Folate biosynthesis_Homo sapiens_hsa007901.08694341
35Tryptophan metabolism_Homo sapiens_hsa003801.06263678
36Non-homologous end-joining_Homo sapiens_hsa034501.03050894
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99469396
38Oxidative phosphorylation_Homo sapiens_hsa001900.98146422
39Pyruvate metabolism_Homo sapiens_hsa006200.97448589
40Colorectal cancer_Homo sapiens_hsa052100.95429419
41Dopaminergic synapse_Homo sapiens_hsa047280.93670479
42Histidine metabolism_Homo sapiens_hsa003400.92663485
43Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91689991
44Parkinsons disease_Homo sapiens_hsa050120.88942845
45Calcium signaling pathway_Homo sapiens_hsa040200.87788017
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87356144
47Oocyte meiosis_Homo sapiens_hsa041140.85378913
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85298104
49Long-term depression_Homo sapiens_hsa047300.84814082
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84057774
51Phototransduction_Homo sapiens_hsa047440.82605240
52Nitrogen metabolism_Homo sapiens_hsa009100.80562750
53Lysine degradation_Homo sapiens_hsa003100.80093666
54Taste transduction_Homo sapiens_hsa047420.79954844
55Pancreatic secretion_Homo sapiens_hsa049720.79871301
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.79354458
57Cardiac muscle contraction_Homo sapiens_hsa042600.78752034
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78325843
59Alzheimers disease_Homo sapiens_hsa050100.78011980
60GABAergic synapse_Homo sapiens_hsa047270.75322713
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74962798
62Ether lipid metabolism_Homo sapiens_hsa005650.74042389
63beta-Alanine metabolism_Homo sapiens_hsa004100.71529571
64Hedgehog signaling pathway_Homo sapiens_hsa043400.66794805
65Cholinergic synapse_Homo sapiens_hsa047250.65919863
66Homologous recombination_Homo sapiens_hsa034400.65035219
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58088115
68FoxO signaling pathway_Homo sapiens_hsa040680.58006630
69Amphetamine addiction_Homo sapiens_hsa050310.56452330
70Morphine addiction_Homo sapiens_hsa050320.56294824
71Arginine biosynthesis_Homo sapiens_hsa002200.55783711
72Olfactory transduction_Homo sapiens_hsa047400.53891418
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53737031
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51788865
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51401441
76Purine metabolism_Homo sapiens_hsa002300.50573548
77Gastric acid secretion_Homo sapiens_hsa049710.50065653
78Adherens junction_Homo sapiens_hsa045200.49594896
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48163684
80mRNA surveillance pathway_Homo sapiens_hsa030150.45882501
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43746053
82Spliceosome_Homo sapiens_hsa030400.43015398
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42542983
84Serotonergic synapse_Homo sapiens_hsa047260.38371733
85Systemic lupus erythematosus_Homo sapiens_hsa053220.38096964
86Alcoholism_Homo sapiens_hsa050340.37960493
87Inositol phosphate metabolism_Homo sapiens_hsa005620.37611797
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37193072
89Salivary secretion_Homo sapiens_hsa049700.36580246
90Axon guidance_Homo sapiens_hsa043600.31414745
91Mismatch repair_Homo sapiens_hsa034300.31407242
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28978917
93Vitamin digestion and absorption_Homo sapiens_hsa049770.28338996
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28148144
95Peroxisome_Homo sapiens_hsa041460.26866408
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.26840791
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26833675
98Arachidonic acid metabolism_Homo sapiens_hsa005900.26482197
99Platelet activation_Homo sapiens_hsa046110.25858148
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23612709

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