RPL30P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.86384678
2translational termination (GO:0006415)6.59460664
3ribosomal small subunit assembly (GO:0000028)6.20233247
4SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.71989332
5translational elongation (GO:0006414)5.65038731
6cotranslational protein targeting to membrane (GO:0006613)5.60048781
7protein targeting to ER (GO:0045047)5.57202069
8establishment of protein localization to endoplasmic reticulum (GO:0072599)5.31515803
9protein localization to endoplasmic reticulum (GO:0070972)5.22665573
10cellular protein complex disassembly (GO:0043624)4.92718141
11ATP synthesis coupled proton transport (GO:0015986)4.86685226
12energy coupled proton transport, down electrochemical gradient (GO:0015985)4.86685226
13viral life cycle (GO:0019058)4.77289792
14DNA deamination (GO:0045006)4.75361506
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.74205417
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.64861825
17nucleotide salvage (GO:0043173)4.64253842
18ribosomal small subunit biogenesis (GO:0042274)4.54767666
19positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)4.50735629
20tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.38359346
21RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.38359346
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.37653779
23translational initiation (GO:0006413)4.29442402
24maturation of SSU-rRNA (GO:0030490)4.14278744
25respiratory electron transport chain (GO:0022904)4.08462900
26electron transport chain (GO:0022900)4.03325261
27protein complex disassembly (GO:0043241)4.02587800
28protein complex biogenesis (GO:0070271)3.99792516
29translation (GO:0006412)3.94824152
30establishment of protein localization to mitochondrial membrane (GO:0090151)3.89127608
31nucleoside salvage (GO:0043174)3.88964228
32cytochrome complex assembly (GO:0017004)3.83486797
33macromolecular complex disassembly (GO:0032984)3.80347825
34pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.78485177
35UMP biosynthetic process (GO:0006222)3.78485177
36pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.78485177
37UMP metabolic process (GO:0046049)3.78485177
38ribosomal large subunit biogenesis (GO:0042273)3.78463200
39protein targeting to membrane (GO:0006612)3.73729333
40pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.72861741
41mitochondrial respiratory chain complex assembly (GO:0033108)3.71718758
42pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.66994518
43regulation of hypersensitivity (GO:0002883)3.56968155
44pyrimidine-containing compound salvage (GO:0008655)3.46845631
45pyrimidine nucleoside salvage (GO:0043097)3.46845631
46positive regulation of translational initiation (GO:0045948)3.41253130
47CTP metabolic process (GO:0046036)3.37917762
48CTP biosynthetic process (GO:0006241)3.37917762
49positive regulation of signal transduction by p53 class mediator (GO:1901798)3.35459777
50behavioral response to nicotine (GO:0035095)3.34053477
51pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.32189682
52positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.30925308
53regulation of activation of Janus kinase activity (GO:0010533)3.29956180
54respiratory chain complex IV assembly (GO:0008535)3.27832624
55nuclear-transcribed mRNA catabolic process (GO:0000956)3.23352653
56purine nucleotide salvage (GO:0032261)3.17489634
57chaperone-mediated protein transport (GO:0072321)3.14448685
58negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.08235458
59gonadal mesoderm development (GO:0007506)3.01920021
60mRNA catabolic process (GO:0006402)3.00739169
61hydrogen ion transmembrane transport (GO:1902600)2.98534365
62ATP biosynthetic process (GO:0006754)2.96941924
63ribonucleoside triphosphate biosynthetic process (GO:0009201)2.95745931
64pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.93221057
65mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.93142146
66mitochondrial respiratory chain complex I assembly (GO:0032981)2.93142146
67NADH dehydrogenase complex assembly (GO:0010257)2.93142146
68platelet dense granule organization (GO:0060155)2.89127688
69positive regulation of mast cell activation involved in immune response (GO:0033008)2.87539522
70positive regulation of mast cell degranulation (GO:0043306)2.87539522
71RNA catabolic process (GO:0006401)2.83241214
72cytidine deamination (GO:0009972)2.81516478
73cytidine metabolic process (GO:0046087)2.81516478
74cytidine catabolic process (GO:0006216)2.81516478
75pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.80734667
76secretory granule organization (GO:0033363)2.80299509
77pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.79460076
78pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.78685140
79proton transport (GO:0015992)2.78077955
80regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.76504211
81maturation of 5.8S rRNA (GO:0000460)2.75240279
82ubiquinone biosynthetic process (GO:0006744)2.74611147
83regulation of regulatory T cell differentiation (GO:0045589)2.74344143
84purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.74187474
85hydrogen transport (GO:0006818)2.73605169
86pyrimidine nucleotide catabolic process (GO:0006244)2.73320413
87piRNA metabolic process (GO:0034587)2.73099181
88purine nucleoside triphosphate biosynthetic process (GO:0009145)2.72932310
89regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.71463010
90signal complex assembly (GO:0007172)2.70981712
91neutrophil activation involved in immune response (GO:0002283)2.65510341
92pseudouridine synthesis (GO:0001522)2.65407394
93megakaryocyte development (GO:0035855)2.63581947
94cellular component biogenesis (GO:0044085)2.59846159
95regulation of cellular respiration (GO:0043457)2.58811060
96positive regulation of mast cell activation (GO:0033005)2.55550450
97regulation of mitochondrial translation (GO:0070129)2.54957442
98preassembly of GPI anchor in ER membrane (GO:0016254)2.53777721
99establishment of protein localization to membrane (GO:0090150)2.53678105
100pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.52844674

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.98224545
2BP1_19119308_ChIP-ChIP_Hs578T_Human2.93732354
3GABP_17652178_ChIP-ChIP_JURKAT_Human2.86363238
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.85390037
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.45976979
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.45684004
7VDR_22108803_ChIP-Seq_LS180_Human2.43181396
8EZH2_22144423_ChIP-Seq_EOC_Human2.34156433
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32898524
10ZNF274_21170338_ChIP-Seq_K562_Hela2.20431770
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.19851534
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.17488122
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10256687
14PCGF2_27294783_Chip-Seq_NPCs_Mouse2.08789769
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.00595551
16TAF15_26573619_Chip-Seq_HEK293_Human1.96641742
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95688988
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90749887
19ETS1_20019798_ChIP-Seq_JURKAT_Human1.84994064
20ELF1_17652178_ChIP-ChIP_JURKAT_Human1.83758688
21POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.81680943
22VDR_23849224_ChIP-Seq_CD4+_Human1.79700567
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77899797
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76746140
25IGF1R_20145208_ChIP-Seq_DFB_Human1.74487450
26ELK1_19687146_ChIP-ChIP_HELA_Human1.56711259
27FOXP3_21729870_ChIP-Seq_TREG_Human1.52185871
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.50321089
29GATA3_26560356_Chip-Seq_TH2_Human1.48582770
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.48506741
31TP53_22573176_ChIP-Seq_HFKS_Human1.47377081
32MYC_18555785_ChIP-Seq_MESCs_Mouse1.45658425
33TAF2_19829295_ChIP-Seq_ESCs_Human1.44182833
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43309652
35AR_20517297_ChIP-Seq_VCAP_Human1.40212928
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.38158865
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.37222387
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36711562
39RNF2_27304074_Chip-Seq_NSC_Mouse1.35650290
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32713730
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.32512569
42AUTS2_25519132_ChIP-Seq_293T-REX_Human1.32403654
43NCOR_22424771_ChIP-Seq_293T_Human1.31250344
44PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.30739458
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.30728834
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29398434
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.29398434
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28771426
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.28164488
50MYC_18940864_ChIP-ChIP_HL60_Human1.27104206
51ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26661146
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24261673
53PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.24212296
54FUS_26573619_Chip-Seq_HEK293_Human1.23044910
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22869020
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.22813974
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22460783
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22126560
59IRF1_19129219_ChIP-ChIP_H3396_Human1.20700969
60EWS_26573619_Chip-Seq_HEK293_Human1.20077595
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19130314
62GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.18543875
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17746789
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17687641
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16288821
66SOX2_19829295_ChIP-Seq_ESCs_Human1.14289135
67NANOG_19829295_ChIP-Seq_ESCs_Human1.14289135
68CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.12794719
69GATA6_21074721_ChIP-Seq_CACO-2_Human1.12596645
70RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12395353
71EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11246180
72ER_23166858_ChIP-Seq_MCF-7_Human1.10600891
73NANOG_20526341_ChIP-Seq_ESCs_Human1.10108951
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09368453
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09271699
76MYC_19829295_ChIP-Seq_ESCs_Human1.09230913
77GATA3_21878914_ChIP-Seq_MCF-7_Human1.08909056
78ERA_21632823_ChIP-Seq_H3396_Human1.08023001
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05823996
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.04276630
81GBX2_23144817_ChIP-Seq_PC3_Human1.04078532
82RBPJ_21746931_ChIP-Seq_IB4_Human1.03651738
83JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03280392
84P300_19829295_ChIP-Seq_ESCs_Human1.02189859
85CREB1_15753290_ChIP-ChIP_HEK293T_Human1.01520604
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.01504882
87MYB_26560356_Chip-Seq_TH2_Human1.01280533
88RUNX_20019798_ChIP-Seq_JUKART_Human1.01063962
89SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99888955
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99305254
91TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99234523
92FOXH1_21741376_ChIP-Seq_EPCs_Human0.98337974
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98135418
94IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98061818
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.96945524
96EZH2_27294783_Chip-Seq_ESCs_Mouse0.96023668
97CRX_20693478_ChIP-Seq_RETINA_Mouse0.95234554
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94692147
99CBP_20019798_ChIP-Seq_JUKART_Human0.94692147
100STAT1_20625510_ChIP-Seq_HELA_Human0.94290815

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.98932062
2MP0003646_muscle_fatigue4.15996918
3MP0005671_abnormal_response_to2.98612630
4MP0002837_dystrophic_cardiac_calcinosis2.92928289
5MP0006292_abnormal_olfactory_placode2.91460585
6MP0001835_abnormal_antigen_presentation2.67853798
7MP0002163_abnormal_gland_morphology2.48513622
8MP0003806_abnormal_nucleotide_metabolis2.36184530
9MP0008875_abnormal_xenobiotic_pharmacok2.10002565
10MP0008872_abnormal_physiological_respon1.97553517
11MP0005646_abnormal_pituitary_gland1.93631535
12MP0002102_abnormal_ear_morphology1.91022890
13MP0000372_irregular_coat_pigmentation1.89377601
14MP0009764_decreased_sensitivity_to1.83429239
15MP0008995_early_reproductive_senescence1.80246120
16MP0009333_abnormal_splenocyte_physiolog1.79159101
17MP0004145_abnormal_muscle_electrophysio1.78231570
18MP0002876_abnormal_thyroid_physiology1.75849014
19MP0006072_abnormal_retinal_apoptosis1.75468045
20MP0005379_endocrine/exocrine_gland_phen1.69649810
21MP0005000_abnormal_immune_tolerance1.63915129
22MP0002638_abnormal_pupillary_reflex1.61251209
23MP0005551_abnormal_eye_electrophysiolog1.56034204
24MP0008877_abnormal_DNA_methylation1.51880860
25MP0002148_abnormal_hypersensitivity_rea1.51772146
26MP0004142_abnormal_muscle_tone1.51455599
27MP0001905_abnormal_dopamine_level1.50384712
28MP0001873_stomach_inflammation1.48667209
29MP0002277_abnormal_respiratory_mucosa1.46708914
30MP0003786_premature_aging1.46498438
31MP0009785_altered_susceptibility_to1.45035827
32MP0001800_abnormal_humoral_immune1.44650583
33MP0005645_abnormal_hypothalamus_physiol1.42967987
34MP0003195_calcinosis1.40251440
35MP0002234_abnormal_pharynx_morphology1.38902838
36MP0006082_CNS_inflammation1.36356916
37MP0005075_abnormal_melanosome_morpholog1.33474264
38MP0005410_abnormal_fertilization1.33041590
39MP0001348_abnormal_lacrimal_gland1.29910264
40MP0003724_increased_susceptibility_to1.29751324
41MP0005360_urolithiasis1.25185831
42MP0009046_muscle_twitch1.22682802
43MP0001986_abnormal_taste_sensitivity1.22213219
44MP0004147_increased_porphyrin_level1.19305863
45MP0002723_abnormal_immune_serum1.18567006
46MP0001968_abnormal_touch/_nociception1.16048812
47MP0005253_abnormal_eye_physiology1.12981139
48MP0006036_abnormal_mitochondrial_physio1.12166515
49MP0002933_joint_inflammation1.10320049
50MP0004885_abnormal_endolymph1.08923776
51MP0002736_abnormal_nociception_after1.08503898
52MP0005367_renal/urinary_system_phenotyp1.08076590
53MP0000516_abnormal_urinary_system1.08076590
54MP0005387_immune_system_phenotype1.08024360
55MP0001790_abnormal_immune_system1.08024360
56MP0003880_abnormal_central_pattern1.07268933
57MP0003011_delayed_dark_adaptation1.06792512
58MP0001346_abnormal_lacrimal_gland1.05859079
59MP0002095_abnormal_skin_pigmentation1.05535045
60MP0003763_abnormal_thymus_physiology1.05407675
61MP0003787_abnormal_imprinting1.05404392
62MP0002452_abnormal_antigen_presenting1.05133801
63MP0005389_reproductive_system_phenotype1.01505516
64MP0010155_abnormal_intestine_physiology1.00482771
65MP0006276_abnormal_autonomic_nervous0.99981802
66MP0002420_abnormal_adaptive_immunity0.97817300
67MP0001819_abnormal_immune_cell0.97345796
68MP0008775_abnormal_heart_ventricle0.95758325
69MP0002272_abnormal_nervous_system0.93773038
70MP0000685_abnormal_immune_system0.93007264
71MP0009745_abnormal_behavioral_response0.92417294
72MP0005503_abnormal_tendon_morphology0.92250929
73MP0003878_abnormal_ear_physiology0.92100051
74MP0005377_hearing/vestibular/ear_phenot0.92100051
75MP0008789_abnormal_olfactory_epithelium0.90700181
76MP0001919_abnormal_reproductive_system0.90346122
77MP0003137_abnormal_impulse_conducting0.87856959
78MP0010386_abnormal_urinary_bladder0.87824837
79MP0005636_abnormal_mineral_homeostasis0.86676434
80MP0005025_abnormal_response_to0.85333049
81MP0001485_abnormal_pinna_reflex0.84953597
82MP0002138_abnormal_hepatobiliary_system0.81140888
83MP0005085_abnormal_gallbladder_physiolo0.80002952
84MP0002006_tumorigenesis0.79922117
85MP0002938_white_spotting0.79537056
86MP0001845_abnormal_inflammatory_respons0.78538728
87MP0003436_decreased_susceptibility_to0.78145883
88MP0005084_abnormal_gallbladder_morpholo0.76679343
89MP0001756_abnormal_urination0.76408711
90MP0001765_abnormal_ion_homeostasis0.75915757
91MP0002166_altered_tumor_susceptibility0.75172665
92MP0002160_abnormal_reproductive_system0.73837443
93MP0001663_abnormal_digestive_system0.72770398
94MP0001661_extended_life_span0.72251756
95MP0001970_abnormal_pain_threshold0.71879561
96MP0000631_abnormal_neuroendocrine_gland0.71053059
97MP0001502_abnormal_circadian_rhythm0.69037662
98MP0005332_abnormal_amino_acid0.69015537
99MP0003866_abnormal_defecation0.68511743
100MP0005195_abnormal_posterior_eye0.67514904

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.40052000
2Mitochondrial inheritance (HP:0001427)4.24884067
3Congenital, generalized hypertrichosis (HP:0004540)4.18529218
4Abnormal mitochondria in muscle tissue (HP:0008316)3.80972001
5Increased CSF lactate (HP:0002490)3.74477365
6Increased hepatocellular lipid droplets (HP:0006565)3.67286727
7Progressive macrocephaly (HP:0004481)3.66406423
8Abolished electroretinogram (ERG) (HP:0000550)3.65723391
9Acute encephalopathy (HP:0006846)3.55024572
10Decreased electroretinogram (ERG) amplitude (HP:0000654)3.51165355
11Hypoplasia of the pons (HP:0012110)3.45425419
12Lipid accumulation in hepatocytes (HP:0006561)3.43495863
13Congenital stationary night blindness (HP:0007642)3.34727040
14Type II lissencephaly (HP:0007260)3.34600733
15Hepatocellular necrosis (HP:0001404)3.20482160
16Abnormality of the pons (HP:0007361)3.12039600
17Renal Fanconi syndrome (HP:0001994)3.11898121
18Increased intramyocellular lipid droplets (HP:0012240)3.04752845
19Retinal atrophy (HP:0001105)3.00358379
20Abnormality of cells of the erythroid lineage (HP:0012130)2.95541711
21Absent rod-and cone-mediated responses on ERG (HP:0007688)2.93395696
22Cerebellar dysplasia (HP:0007033)2.92568379
23Elevated erythrocyte sedimentation rate (HP:0003565)2.91657293
243-Methylglutaconic aciduria (HP:0003535)2.86274777
25Hepatic necrosis (HP:0002605)2.76124853
26IgG deficiency (HP:0004315)2.74838127
27Abnormal rod and cone electroretinograms (HP:0008323)2.73477270
28Exertional dyspnea (HP:0002875)2.71293342
29Retinal dysplasia (HP:0007973)2.69512846
30Macrocytic anemia (HP:0001972)2.64966141
31Cerebral edema (HP:0002181)2.63489907
32Increased muscle lipid content (HP:0009058)2.58203733
33Abnormal number of erythroid precursors (HP:0012131)2.56958674
34Molar tooth sign on MRI (HP:0002419)2.54440167
35Abnormality of midbrain morphology (HP:0002418)2.54440167
36Pancreatic cysts (HP:0001737)2.52882756
37Decreased central vision (HP:0007663)2.50655598
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.49241648
39Pallor (HP:0000980)2.46402995
40Optic disc pallor (HP:0000543)2.34409417
41Hyperglycinemia (HP:0002154)2.33262301
42Asplenia (HP:0001746)2.32283556
43Pancreatic fibrosis (HP:0100732)2.31013040
44Reticulocytopenia (HP:0001896)2.30569755
45True hermaphroditism (HP:0010459)2.29061890
46Hypoproteinemia (HP:0003075)2.28887007
47Aplasia/Hypoplasia of the spleen (HP:0010451)2.25068579
48Aplastic anemia (HP:0001915)2.22179227
49Pendular nystagmus (HP:0012043)2.20501126
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.16707778
51Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.16707778
52Lactic acidosis (HP:0003128)2.15929400
53Respiratory failure (HP:0002878)2.13220711
54Concave nail (HP:0001598)2.10538836
55Nephronophthisis (HP:0000090)2.10426147
56Abnormality of renal resorption (HP:0011038)2.08194806
57Aplasia/Hypoplasia affecting the retina (HP:0008061)2.07880348
58Leukodystrophy (HP:0002415)2.06331311
59Abnormal drinking behavior (HP:0030082)2.04056514
60Polydipsia (HP:0001959)2.04056514
61Increased serum lactate (HP:0002151)2.00733229
62Abnormality of urine glucose concentration (HP:0011016)1.99939723
63Glycosuria (HP:0003076)1.99939723
64Methylmalonic acidemia (HP:0002912)1.99408630
65Increased IgM level (HP:0003496)1.97824521
66Hyperphosphaturia (HP:0003109)1.94984492
67Dynein arm defect of respiratory motile cilia (HP:0012255)1.94411346
68Absent/shortened dynein arms (HP:0200106)1.94411346
69Type 2 muscle fiber atrophy (HP:0003554)1.91229739
70Stomatitis (HP:0010280)1.90784666
71Abnormality of B cell number (HP:0010975)1.90267105
72Hip dysplasia (HP:0001385)1.88359255
73Abnormality of the prostate (HP:0008775)1.87582756
74Increased corneal curvature (HP:0100692)1.87490159
75Keratoconus (HP:0000563)1.87490159
76Abnormality of the renal medulla (HP:0100957)1.85585624
77CNS demyelination (HP:0007305)1.83687788
78Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.82156635
79Abnormality of the renal cortex (HP:0011035)1.81557956
80Polyuria (HP:0000103)1.80289650
81Dyskinesia (HP:0100660)1.79376992
82Symphalangism affecting the phalanges of the hand (HP:0009773)1.79106278
83Attenuation of retinal blood vessels (HP:0007843)1.75335985
84Lethargy (HP:0001254)1.75007022
85Progressive microcephaly (HP:0000253)1.72680170
86Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.72517876
87Severe muscular hypotonia (HP:0006829)1.72431760
88Abnormality of the phalanges of the 5th finger (HP:0004213)1.71115567
89Male pseudohermaphroditism (HP:0000037)1.71024957
90B lymphocytopenia (HP:0010976)1.70516640
91Type I transferrin isoform profile (HP:0003642)1.70339380
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69116969
93Abnormality of alanine metabolism (HP:0010916)1.69116969
94Hyperalaninemia (HP:0003348)1.69116969
95Abnormal respiratory motile cilium physiology (HP:0012261)1.68285432
96Medial flaring of the eyebrow (HP:0010747)1.67349485
97Sclerocornea (HP:0000647)1.66673572
98Respiratory difficulties (HP:0002880)1.66614281
99Parakeratosis (HP:0001036)1.65922017
100Erythroderma (HP:0001019)1.63583599

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR23.17289054
2MAP4K13.14969910
3TXK3.05252247
4MAP3K122.85915616
5RIPK12.83466254
6TLK12.79841015
7CDK192.64802912
8ADRBK22.58185032
9BCKDK2.30515553
10BMPR1B2.10922642
11GRK12.09720159
12LIMK12.07018211
13MYLK2.03011570
14ZAK1.95310812
15MAP4K21.87504434
16KDR1.81646021
17GRK61.78469920
18DAPK31.65837877
19MUSK1.62318990
20TAOK31.57514456
21FRK1.50857919
22PASK1.45340094
23WNK41.43479132
24TIE11.41644746
25TEC1.38565283
26PINK11.32888362
27WNK31.32237120
28INSRR1.29302072
29MARK31.27839185
30IKBKB1.26445682
31PRKCI1.23294942
32OXSR11.22718018
33SYK1.20775383
34CSF1R1.18300266
35PRKCG1.16144825
36PRKCE1.10715773
37ITK1.04186534
38VRK11.02773522
39LYN1.02550086
40PIM21.01320677
41NEK11.01014725
42PIM10.99624456
43ILK0.98171553
44GRK70.97495570
45LCK0.95737888
46NME20.95179498
47PRKCQ0.93804841
48STK160.93670028
49OBSCN0.92763942
50DAPK10.91393413
51CAMKK20.90800474
52BTK0.86373043
53PKN10.85983160
54NUAK10.85157755
55RPS6KA50.84767546
56CDK80.83794316
57ERBB30.83182662
58MAP3K40.81942521
59PTK2B0.81250526
60PLK40.81125532
61KIT0.74028725
62MAP2K70.73264473
63VRK20.71435391
64PRKCD0.69405468
65DYRK20.68822081
66STK100.68591584
67STK390.63932097
68CSNK2A20.60743492
69PIK3CG0.60301575
70ADRBK10.60152207
71EIF2AK30.59801347
72IGF1R0.59583911
73IKBKE0.57442962
74FLT30.56213557
75PRKCA0.56006519
76FES0.54436054
77CSNK1G10.54197570
78CSNK2A10.53796266
79TNK20.53314418
80TGFBR10.52580814
81PRKACA0.52152984
82PHKG10.51847965
83PHKG20.51847965
84CAMKK10.51089597
85TESK10.50703655
86PLK20.49665341
87EPHA40.48108669
88GRK50.47778952
89AURKB0.46103317
90ROCK10.45891370
91TESK20.45021214
92MAPK150.44870778
93CAMK2A0.43808202
94FYN0.40853654
95CSK0.40069136
96SCYL20.39289573
97PIK3CA0.38477463
98EGFR0.36957663
99ABL10.36639005
100CSNK1G30.36537472

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.17936506
2Oxidative phosphorylation_Homo sapiens_hsa001903.77314027
3Asthma_Homo sapiens_hsa053103.49709368
4Graft-versus-host disease_Homo sapiens_hsa053323.04107293
5Allograft rejection_Homo sapiens_hsa053303.01787999
6Parkinsons disease_Homo sapiens_hsa050123.00230087
7Autoimmune thyroid disease_Homo sapiens_hsa053202.94887246
8Sulfur relay system_Homo sapiens_hsa041222.65598254
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.61941807
10Type I diabetes mellitus_Homo sapiens_hsa049402.46485142
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.39801746
12Proteasome_Homo sapiens_hsa030502.24958162
13Alzheimers disease_Homo sapiens_hsa050102.14866652
14Cardiac muscle contraction_Homo sapiens_hsa042602.09663940
15Protein export_Homo sapiens_hsa030601.99566678
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98613944
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.98556641
18Huntingtons disease_Homo sapiens_hsa050161.94061000
19Primary immunodeficiency_Homo sapiens_hsa053401.74619080
20RNA polymerase_Homo sapiens_hsa030201.69380842
21Antigen processing and presentation_Homo sapiens_hsa046121.63306923
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47141864
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43934516
24Linoleic acid metabolism_Homo sapiens_hsa005911.35523608
25Hematopoietic cell lineage_Homo sapiens_hsa046401.33754324
26Rheumatoid arthritis_Homo sapiens_hsa053231.32244416
27RNA degradation_Homo sapiens_hsa030181.28278780
28Pyrimidine metabolism_Homo sapiens_hsa002401.25492013
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.20227135
30Viral myocarditis_Homo sapiens_hsa054161.18479409
31Tyrosine metabolism_Homo sapiens_hsa003501.18238402
32Staphylococcus aureus infection_Homo sapiens_hsa051501.16419636
33Phototransduction_Homo sapiens_hsa047441.13080610
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08991671
35Homologous recombination_Homo sapiens_hsa034401.02540728
36Olfactory transduction_Homo sapiens_hsa047401.00847938
37Nitrogen metabolism_Homo sapiens_hsa009100.99841750
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98902864
39One carbon pool by folate_Homo sapiens_hsa006700.95073511
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94162687
41Systemic lupus erythematosus_Homo sapiens_hsa053220.91934188
42SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88170675
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85050252
44Regulation of autophagy_Homo sapiens_hsa041400.85003539
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84784840
46Fat digestion and absorption_Homo sapiens_hsa049750.82471738
47Caffeine metabolism_Homo sapiens_hsa002320.81769038
48Arachidonic acid metabolism_Homo sapiens_hsa005900.76371947
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75155209
50Leishmaniasis_Homo sapiens_hsa051400.73202583
51Chemical carcinogenesis_Homo sapiens_hsa052040.69892255
52Purine metabolism_Homo sapiens_hsa002300.69637251
53Nicotine addiction_Homo sapiens_hsa050330.69039524
54Tryptophan metabolism_Homo sapiens_hsa003800.68400891
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67942112
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61892755
57Retinol metabolism_Homo sapiens_hsa008300.59845931
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58116525
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57681058
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57364408
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.56654739
62DNA replication_Homo sapiens_hsa030300.56606183
63Peroxisome_Homo sapiens_hsa041460.55336281
64T cell receptor signaling pathway_Homo sapiens_hsa046600.55198318
65Fanconi anemia pathway_Homo sapiens_hsa034600.51491360
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.50862348
67Metabolic pathways_Homo sapiens_hsa011000.50331016
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.49880339
69Taste transduction_Homo sapiens_hsa047420.48337377
70Sulfur metabolism_Homo sapiens_hsa009200.48105902
71Ether lipid metabolism_Homo sapiens_hsa005650.47348295
72Collecting duct acid secretion_Homo sapiens_hsa049660.45000229
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40670474
74Pentose phosphate pathway_Homo sapiens_hsa000300.40471508
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40407626
76Butanoate metabolism_Homo sapiens_hsa006500.39067961
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37266963
78Morphine addiction_Homo sapiens_hsa050320.37053982
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34260562
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32303389
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31943093
82Base excision repair_Homo sapiens_hsa034100.31130858
83Basal transcription factors_Homo sapiens_hsa030220.28782907
84Malaria_Homo sapiens_hsa051440.28667867
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.28110579
86Measles_Homo sapiens_hsa051620.27796545
87Mismatch repair_Homo sapiens_hsa034300.27496609
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26986022
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26209852
90Salivary secretion_Homo sapiens_hsa049700.26148585
91RNA transport_Homo sapiens_hsa030130.24661783
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24577470
93Spliceosome_Homo sapiens_hsa030400.24188743
94Glycerolipid metabolism_Homo sapiens_hsa005610.23609129
95Nucleotide excision repair_Homo sapiens_hsa034200.23159126
96Mineral absorption_Homo sapiens_hsa049780.22039513
97Propanoate metabolism_Homo sapiens_hsa006400.20765652
98Phagosome_Homo sapiens_hsa041450.18551674
99Glutathione metabolism_Homo sapiens_hsa004800.17061966
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.16340650

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