RPL31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L31E family of ribosomal proteins. It is located in the cytoplasm. Higher levels of expression of this gene in familial adenomatous polyps compared to matched normal tissues have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* translational elongation (GO:0006414)9.53229469
2* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)9.42630089
3* protein targeting to ER (GO:0045047)9.26766889
4* cotranslational protein targeting to membrane (GO:0006613)9.26733816
5ribosomal large subunit biogenesis (GO:0042273)9.01880449
6* establishment of protein localization to endoplasmic reticulum (GO:0072599)8.89295863
7* cellular protein complex disassembly (GO:0043624)8.81048817
8* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)8.69795680
9* protein localization to endoplasmic reticulum (GO:0070972)8.63569335
10* viral life cycle (GO:0019058)8.61120966
11maturation of SSU-rRNA (GO:0030490)8.55373778
12* translational initiation (GO:0006413)8.17830069
13* protein complex disassembly (GO:0043241)7.67347766
14* macromolecular complex disassembly (GO:0032984)7.15741023
15* protein targeting to membrane (GO:0006612)6.28730588
16* nuclear-transcribed mRNA catabolic process (GO:0000956)6.03518728
17* translation (GO:0006412)5.74099628
18ribonucleoprotein complex biogenesis (GO:0022613)5.71482043
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.70282565
20* mRNA catabolic process (GO:0006402)5.70138916
21respiratory electron transport chain (GO:0022904)5.61742188
22electron transport chain (GO:0022900)5.49904666
23establishment of protein localization to mitochondrial membrane (GO:0090151)5.21560201
24* RNA catabolic process (GO:0006401)5.20750404
25chaperone-mediated protein transport (GO:0072321)5.09774620
26ATP synthesis coupled proton transport (GO:0015986)4.50509551
27energy coupled proton transport, down electrochemical gradient (GO:0015985)4.50509551
28rRNA processing (GO:0006364)4.32242552
29rRNA metabolic process (GO:0016072)4.25585252
30* establishment of protein localization to membrane (GO:0090150)4.22642282
31protein complex biogenesis (GO:0070271)4.20225126
32cellular component biogenesis (GO:0044085)4.14539614
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.12360502
34mitochondrial respiratory chain complex I assembly (GO:0032981)4.12360502
35NADH dehydrogenase complex assembly (GO:0010257)4.12360502
36inner mitochondrial membrane organization (GO:0007007)4.04226449
37ATP biosynthetic process (GO:0006754)4.01754704
38sequestering of actin monomers (GO:0042989)3.97120244
39mitochondrial respiratory chain complex assembly (GO:0033108)3.94559143
40* protein targeting (GO:0006605)3.76316930
41protein neddylation (GO:0045116)3.75428380
42ncRNA 3-end processing (GO:0043628)3.74598655
43formation of translation preinitiation complex (GO:0001731)3.74103123
44* establishment of protein localization to organelle (GO:0072594)3.70713563
45purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.68245188
46purine nucleoside triphosphate biosynthetic process (GO:0009145)3.65462226
47hydrogen ion transmembrane transport (GO:1902600)3.65133441
48mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.60075516
49oxidative phosphorylation (GO:0006119)3.32819743
50ribonucleoside triphosphate biosynthetic process (GO:0009201)3.23717649
51* protein localization to membrane (GO:0072657)3.23360166
52proton transport (GO:0015992)3.16939447
53* cellular component disassembly (GO:0022411)3.13725463
54spliceosomal complex assembly (GO:0000245)3.12985243
55hydrogen transport (GO:0006818)3.10941570
56negative regulation of RNA splicing (GO:0033119)3.05953161
57establishment of integrated proviral latency (GO:0075713)3.03899531
58regulation of mitochondrial translation (GO:0070129)2.98335014
59intracellular protein transmembrane import (GO:0044743)2.96670937
60protein localization to kinetochore (GO:0034501)2.94944745
61UTP biosynthetic process (GO:0006228)2.91956381
62spliceosomal snRNP assembly (GO:0000387)2.90482901
63DNA unwinding involved in DNA replication (GO:0006268)2.89174843
64protein localization to chromosome, centromeric region (GO:0071459)2.87162902
65GTP biosynthetic process (GO:0006183)2.86313942
66midbrain development (GO:0030901)2.82823358
67nucleoside triphosphate biosynthetic process (GO:0009142)2.82738412
68DNA deamination (GO:0045006)2.81479382
69* protein localization to organelle (GO:0033365)2.80790101
70DNA strand elongation involved in DNA replication (GO:0006271)2.80119383
71purine nucleoside monophosphate biosynthetic process (GO:0009127)2.78283907
72purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.78283907
73telomere maintenance via semi-conservative replication (GO:0032201)2.77999799
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.77935116
75ncRNA processing (GO:0034470)2.77050829
76folic acid-containing compound biosynthetic process (GO:0009396)2.76885200
77* gene expression (GO:0010467)2.75369423
78proteasome assembly (GO:0043248)2.74636677
79negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.74589673
80regulation of protein heterodimerization activity (GO:0043497)2.70419427
81keratinocyte proliferation (GO:0043616)2.67333208
82histone mRNA metabolic process (GO:0008334)2.66753525
83pseudouridine synthesis (GO:0001522)2.66467986
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.62332606
85DNA strand elongation (GO:0022616)2.60034675
86tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.59274457
87RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.59274457
88otic vesicle formation (GO:0030916)2.59149642
89mitotic G1 DNA damage checkpoint (GO:0031571)2.58259987
90UTP metabolic process (GO:0046051)2.57884572
91positive regulation of respiratory burst (GO:0060267)2.57310797
927-methylguanosine mRNA capping (GO:0006370)2.56250001
93aerobic respiration (GO:0009060)2.55715853
94termination of RNA polymerase III transcription (GO:0006386)2.55244329
95transcription elongation from RNA polymerase III promoter (GO:0006385)2.55244329
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.53957722
97negative regulation of ligase activity (GO:0051352)2.53957722
98protein-cofactor linkage (GO:0018065)2.52903748
99mitotic metaphase plate congression (GO:0007080)2.52186135
100RNA capping (GO:0036260)2.50604533
1017-methylguanosine RNA capping (GO:0009452)2.50604533
102ncRNA metabolic process (GO:0034660)2.50456175
103ribosome biogenesis (GO:0042254)2.47991574
104establishment of protein localization to mitochondrion (GO:0072655)2.47172841
105protein targeting to mitochondrion (GO:0006626)2.46974293
106epithelial cilium movement (GO:0003351)2.44877505
107pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.44651707
108termination of RNA polymerase II transcription (GO:0006369)2.43682848
109mitochondrial transport (GO:0006839)2.43309938
110ribonucleoprotein complex assembly (GO:0022618)2.42565957
111regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.42240101
112positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.41831919
113G1 DNA damage checkpoint (GO:0044783)2.41772794
114anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.41694831
115thalamus development (GO:0021794)2.41508497
116behavioral response to nicotine (GO:0035095)2.38872782
117mitotic sister chromatid segregation (GO:0000070)2.38522616
118establishment of viral latency (GO:0019043)2.37895229
119rRNA modification (GO:0000154)2.36926754
120negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.36828689
121protein localization to mitochondrion (GO:0070585)2.36606203
122mRNA splicing, via spliceosome (GO:0000398)2.34526392
123RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.34526392
124DNA damage response, detection of DNA damage (GO:0042769)2.34508092
125mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.34506714
126mitotic G1/S transition checkpoint (GO:0044819)2.34208910
127RNA splicing, via transesterification reactions (GO:0000375)2.34172517
128neuron fate determination (GO:0048664)2.33725818
129epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.33420079
130kinetochore organization (GO:0051383)2.32261442
131mitotic recombination (GO:0006312)2.32224852
132telomere maintenance via recombination (GO:0000722)2.32112405
133nucleotide-excision repair, DNA gap filling (GO:0006297)2.31941700
134antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.31069406
135transcription-coupled nucleotide-excision repair (GO:0006283)2.30780423
136chromatin remodeling at centromere (GO:0031055)2.30594311
137ribonucleoside monophosphate biosynthetic process (GO:0009156)2.30211028
138DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.29752056
139nucleoside monophosphate biosynthetic process (GO:0009124)2.29216145
140ribonucleoprotein complex subunit organization (GO:0071826)2.29214277
141telomere maintenance via telomere lengthening (GO:0010833)2.29212611
142DNA replication checkpoint (GO:0000076)2.28957545
143attachment of spindle microtubules to kinetochore (GO:0008608)2.27174087
144pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.27060801
145sister chromatid segregation (GO:0000819)2.26160201
146CENP-A containing nucleosome assembly (GO:0034080)2.26126432
147signal transduction involved in DNA integrity checkpoint (GO:0072401)2.24637345
148* viral transcription (GO:0019083)11.7776053
149* translational termination (GO:0006415)11.3220531
150ribosomal small subunit biogenesis (GO:0042274)10.9940720
151ribosomal small subunit assembly (GO:0000028)10.3094729

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.35266153
2* MYC_18555785_ChIP-Seq_MESCs_Mouse5.27067843
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.80216367
4* MYC_19079543_ChIP-ChIP_MESCs_Mouse4.12349842
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.97662136
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.83191359
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.67002679
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.27853172
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.19657287
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.18223916
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.10302894
12* XRN2_22483619_ChIP-Seq_HELA_Human2.94744582
13* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.91972832
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.91514589
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91440630
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.87475390
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.86164939
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.78265146
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.77726037
20* GABP_17652178_ChIP-ChIP_JURKAT_Human2.76214547
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50285519
22* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.46470485
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39367149
24DCP1A_22483619_ChIP-Seq_HELA_Human2.38826500
25* TTF2_22483619_ChIP-Seq_HELA_Human2.32003658
26RBPJ_22232070_ChIP-Seq_NCS_Mouse2.29614198
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.20035609
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.12087627
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05658729
30* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01492329
31* VDR_23849224_ChIP-Seq_CD4+_Human2.00659373
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.97426098
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.88793853
34* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84098060
35FOXP3_21729870_ChIP-Seq_TREG_Human1.83668629
36KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.78517449
37ELK1_19687146_ChIP-ChIP_HELA_Human1.77736256
38ELK1_22589737_ChIP-Seq_MCF10A_Human1.71354789
39* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68059517
40ZNF263_19887448_ChIP-Seq_K562_Human1.64999972
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.63544371
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62195385
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.62106590
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61151292
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61044856
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60473454
47* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59823903
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.58233084
49KDM5A_27292631_Chip-Seq_BREAST_Human1.56578195
50* FUS_26573619_Chip-Seq_HEK293_Human1.55623328
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51271586
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50636676
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49757327
54EWS_26573619_Chip-Seq_HEK293_Human1.48909716
55* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.47818839
56EZH2_22144423_ChIP-Seq_EOC_Human1.47691807
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46884040
58SOX2_16153702_ChIP-ChIP_HESCs_Human1.46540832
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44682127
60GABP_19822575_ChIP-Seq_HepG2_Human1.38690631
61VDR_22108803_ChIP-Seq_LS180_Human1.37461983
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34194840
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32214638
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31115917
65AR_21909140_ChIP-Seq_LNCAP_Human1.31002047
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.28985904
67VDR_21846776_ChIP-Seq_THP-1_Human1.28617600
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.26997345
69MYC_18940864_ChIP-ChIP_HL60_Human1.25192803
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25084348
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22354897
72MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18354559
73CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16203385
74MYC_22102868_ChIP-Seq_BL_Human1.15793360
75CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15597653
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14616857
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13817367
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.13221567
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13204202
80SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13006082
81ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12405161
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11237128
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09962696
84* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09175923
85HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09108333
86HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08405456
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08354353
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07594284
89EZH2_27304074_Chip-Seq_ESCs_Mouse1.07392108
90ZNF274_21170338_ChIP-Seq_K562_Hela1.07262714
91OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07165642
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07135664
93RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07012260
94NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05463766
95NANOG_16153702_ChIP-ChIP_HESCs_Human1.03995234
96CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02388637
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01276572
98TP53_22573176_ChIP-Seq_HFKS_Human1.00802820
99* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00675903
100RNF2_27304074_Chip-Seq_NSC_Mouse0.98245874
101CIITA_25753668_ChIP-Seq_RAJI_Human0.97932360
102YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97545076
103SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97135957
104NOTCH1_21737748_ChIP-Seq_TLL_Human0.96580127
105* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95676074
106CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94197599
107ERG_20517297_ChIP-Seq_VCAP_Human0.94075711
108* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93592909
109EGR1_19374776_ChIP-ChIP_THP-1_Human0.91924219
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90501436
111TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90207110
112STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90055197
113CHD1_26751641_Chip-Seq_LNCaP_Human0.89482770
114E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88473712
115CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88199063
116KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.87911440
117KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87911440
118KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87911440
119* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87838161
120* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87802609
121IRF1_19129219_ChIP-ChIP_H3396_Human0.87627836
122SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86880273
123PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86455808
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86385051
125* FLI1_27457419_Chip-Seq_LIVER_Mouse0.86207847
126MAF_26560356_Chip-Seq_TH2_Human0.85970167
127SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.85392239
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84189913
129SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.80917985
130AR_20517297_ChIP-Seq_VCAP_Human0.80545057
131GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78908786
132SRY_22984422_ChIP-ChIP_TESTIS_Rat0.76869836
133SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.72933631
134PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.72829969
135FOXP1_21924763_ChIP-Seq_HESCs_Human0.70685875
136PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.70423755
137TAF15_26573619_Chip-Seq_HEK293_Human0.69645339
138CTBP2_25329375_ChIP-Seq_LNCAP_Human0.67974698
139ETV2_25802403_ChIP-Seq_MESCs_Mouse0.67675605
140ESR1_15608294_ChIP-ChIP_MCF-7_Human0.66878681

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.89373086
2MP0010030_abnormal_orbit_morphology3.98753144
3MP0006292_abnormal_olfactory_placode3.85189340
4MP0000566_synostosis3.34433118
5MP0003693_abnormal_embryo_hatching3.04022171
6MP0004957_abnormal_blastocyst_morpholog3.01506672
7MP0010352_gastrointestinal_tract_polyps2.87015902
8MP0003705_abnormal_hypodermis_morpholog2.65024627
9MP0003077_abnormal_cell_cycle2.23555461
10MP0003111_abnormal_nucleus_morphology2.23303647
11MP0008932_abnormal_embryonic_tissue2.19545767
12MP0003941_abnormal_skin_development2.18240407
13MP0010094_abnormal_chromosome_stability2.15689463
14MP0002796_impaired_skin_barrier2.04189918
15MP0008995_early_reproductive_senescence1.99981525
16MP0002638_abnormal_pupillary_reflex1.93403046
17MP0004142_abnormal_muscle_tone1.83959556
18MP0003011_delayed_dark_adaptation1.79664316
19MP0002249_abnormal_larynx_morphology1.73437638
20MP0005501_abnormal_skin_physiology1.70365927
21MP0003315_abnormal_perineum_morphology1.68446770
22MP0003880_abnormal_central_pattern1.66743163
23MP0005377_hearing/vestibular/ear_phenot1.60638009
24MP0003878_abnormal_ear_physiology1.60638009
25MP0002060_abnormal_skin_morphology1.60326126
26MP0001529_abnormal_vocalization1.60100081
27MP0003567_abnormal_fetal_cardiomyocyte1.59795406
28MP0000372_irregular_coat_pigmentation1.58930553
29MP0000049_abnormal_middle_ear1.58685347
30MP0000631_abnormal_neuroendocrine_gland1.56541988
31MP0008789_abnormal_olfactory_epithelium1.55362399
32MP0001346_abnormal_lacrimal_gland1.50153494
33MP0000537_abnormal_urethra_morphology1.49825599
34MP0004381_abnormal_hair_follicle1.49242114
35MP0000490_abnormal_crypts_of1.47292218
36MP0002877_abnormal_melanocyte_morpholog1.45753702
37MP0009053_abnormal_anal_canal1.43992182
38MP0008007_abnormal_cellular_replicative1.42965656
39MP0002095_abnormal_skin_pigmentation1.39349492
40MP0001485_abnormal_pinna_reflex1.38425802
41MP0002282_abnormal_trachea_morphology1.37111384
42MP0002653_abnormal_ependyma_morphology1.35994948
43MP0000350_abnormal_cell_proliferation1.35452079
44MP0003186_abnormal_redox_activity1.34646462
45MP0003136_yellow_coat_color1.33690680
46MP0000762_abnormal_tongue_morphology1.30276488
47MP0003283_abnormal_digestive_organ1.28939984
48MP0005499_abnormal_olfactory_system1.28375546
49MP0005394_taste/olfaction_phenotype1.28375546
50MP0000750_abnormal_muscle_regeneration1.28021552
51MP0003453_abnormal_keratinocyte_physiol1.26661723
52MP0008438_abnormal_cutaneous_collagen1.25745245
53MP0005084_abnormal_gallbladder_morpholo1.25468482
54MP0005076_abnormal_cell_differentiation1.25260180
55MP0005075_abnormal_melanosome_morpholog1.25119625
56MP0001730_embryonic_growth_arrest1.25039970
57MP0001216_abnormal_epidermal_layer1.24042489
58MP0003938_abnormal_ear_development1.23419669
59MP0004197_abnormal_fetal_growth/weight/1.23395091
60MP0008057_abnormal_DNA_replication1.23339381
61MP0001879_abnormal_lymphatic_vessel1.23246011
62MP0005248_abnormal_Harderian_gland1.22647155
63MP0003786_premature_aging1.22523484
64MP0005023_abnormal_wound_healing1.21865954
65MP0003890_abnormal_embryonic-extraembry1.18579643
66MP0002098_abnormal_vibrissa_morphology1.17566370
67MP0002697_abnormal_eye_size1.16745749
68MP0002138_abnormal_hepatobiliary_system1.15562552
69MP0001293_anophthalmia1.15246627
70MP0005551_abnormal_eye_electrophysiolog1.13388144
71MP0010771_integument_phenotype1.11635031
72MP0004133_heterotaxia1.10939427
73MP0000026_abnormal_inner_ear1.10554787
74MP0003123_paternal_imprinting1.10177904
75MP0000613_abnormal_salivary_gland1.08498980
76MP0009250_abnormal_appendicular_skeleto1.08340174
77MP0004742_abnormal_vestibular_system1.08166623
78MP0000377_abnormal_hair_follicle1.06730066
79MP0002396_abnormal_hematopoietic_system1.06557399
80MP0001286_abnormal_eye_development1.06349156
81MP0002837_dystrophic_cardiac_calcinosis1.05957754
82MP0002938_white_spotting1.05270961
83MP0004885_abnormal_endolymph1.05228216
84MP0001697_abnormal_embryo_size1.04690122
85MP0003942_abnormal_urinary_system1.04604481
86MP0003937_abnormal_limbs/digits/tail_de1.03782241
87MP0004185_abnormal_adipocyte_glucose1.03385544
88MP0001340_abnormal_eyelid_morphology1.00888973
89MP0002085_abnormal_embryonic_tissue1.00434017
90MP0005646_abnormal_pituitary_gland1.00360289
91MP0003385_abnormal_body_wall0.99621105
92MP0009333_abnormal_splenocyte_physiolog0.99213013
93MP0000858_altered_metastatic_potential0.98956457
94MP0002111_abnormal_tail_morphology0.97959815
95MP0002234_abnormal_pharynx_morphology0.97287962
96MP0008058_abnormal_DNA_repair0.96072736
97MP0002751_abnormal_autonomic_nervous0.96022447
98MP0005275_abnormal_skin_tensile0.95826277
99MP0002822_catalepsy0.94591493
100MP0002092_abnormal_eye_morphology0.94587626
101MP0000703_abnormal_thymus_morphology0.94410521
102MP0002080_prenatal_lethality0.93613903
103MP0002932_abnormal_joint_morphology0.93492896
104MP0005253_abnormal_eye_physiology0.93205765
105MP0000383_abnormal_hair_follicle0.92977743
106MP0001905_abnormal_dopamine_level0.92440589
107MP0006072_abnormal_retinal_apoptosis0.92431710
108MP0002084_abnormal_developmental_patter0.92326359
109MP0000778_abnormal_nervous_system0.91981152
110MP0005257_abnormal_intraocular_pressure0.91785514
111MP0006276_abnormal_autonomic_nervous0.91487471
112MP0005195_abnormal_posterior_eye0.91088192
113MP0005408_hypopigmentation0.90689015
114MP0002163_abnormal_gland_morphology0.90375677
115MP0005174_abnormal_tail_pigmentation0.90082970
116MP0003122_maternal_imprinting0.88950631
117MP0001672_abnormal_embryogenesis/_devel0.87827722
118MP0005380_embryogenesis_phenotype0.87827722
119MP0003121_genomic_imprinting0.87220230
120MP0000467_abnormal_esophagus_morphology0.87103674
121MP0002160_abnormal_reproductive_system0.86994185
122MP0000647_abnormal_sebaceous_gland0.86746467
123MP0005391_vision/eye_phenotype0.86194985
124MP0002009_preneoplasia0.85448767
125MP0002102_abnormal_ear_morphology0.85016448
126MP0000733_abnormal_muscle_development0.84237061
127MP0002086_abnormal_extraembryonic_tissu0.83786124
128MP0002210_abnormal_sex_determination0.83571059
129MP0003755_abnormal_palate_morphology0.82690212
130MP0002233_abnormal_nose_morphology0.82370373
131MP0002132_abnormal_respiratory_system0.82360816
132MP0004808_abnormal_hematopoietic_stem0.81541470
133MP0003718_maternal_effect0.81177106
134MP0002019_abnormal_tumor_incidence0.81030444
135MP0000465_gastrointestinal_hemorrhage0.80657688
136MP0002088_abnormal_embryonic_growth/wei0.80648244
137MP0003119_abnormal_digestive_system0.80444157
138MP0002277_abnormal_respiratory_mucosa0.78689256
139MP0000428_abnormal_craniofacial_morphol0.78301254
140MP0003984_embryonic_growth_retardation0.78023803
141MP0003300_gastrointestinal_ulcer0.76980053
142MP0001324_abnormal_eye_pigmentation0.76558572
143MP0002752_abnormal_somatic_nervous0.75939638
144MP0001348_abnormal_lacrimal_gland0.75842516
145MP0009931_abnormal_skin_appearance0.75580101
146MP0002736_abnormal_nociception_after0.74860242
147MP0005508_abnormal_skeleton_morphology0.74659872
148MP0005423_abnormal_somatic_nervous0.74508459
149MP0006054_spinal_hemorrhage0.74337009
150MP0000432_abnormal_head_morphology0.73827731
151MP0003806_abnormal_nucleotide_metabolis0.72755875
152MP0000477_abnormal_intestine_morphology0.72707860
153MP0000313_abnormal_cell_death0.71783203
154MP0001986_abnormal_taste_sensitivity0.67448283
155MP0008877_abnormal_DNA_methylation0.66862382
156MP0001145_abnormal_male_reproductive0.66696938
157MP0004147_increased_porphyrin_level0.66089247
158MP0004145_abnormal_muscle_electrophysio0.64363816
159MP0005389_reproductive_system_phenotype0.64319792
160MP0001963_abnormal_hearing_physiology0.63775330
161MP0000653_abnormal_sex_gland0.63272205
162MP0002928_abnormal_bile_duct0.59453009
163MP0001984_abnormal_olfaction0.59327370
164MP0005171_absent_coat_pigmentation0.58794656
165MP0005645_abnormal_hypothalamus_physiol0.58521478
166MP0006036_abnormal_mitochondrial_physio0.58135567
167MP0001968_abnormal_touch/_nociception0.57887333

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)8.63399020
2Reticulocytopenia (HP:0001896)8.12633312
3Macrocytic anemia (HP:0001972)7.26971141
4Pallor (HP:0000980)6.72569256
5Abnormal hemoglobin (HP:0011902)6.08719199
6Microvesicular hepatic steatosis (HP:0001414)5.90247810
7Stenosis of the external auditory canal (HP:0000402)4.74398879
8Acute encephalopathy (HP:0006846)4.21575778
9Progressive macrocephaly (HP:0004481)4.07938630
10Increased CSF lactate (HP:0002490)3.86274160
113-Methylglutaconic aciduria (HP:0003535)3.71630180
12Aplasia/Hypoplasia of the sacrum (HP:0008517)3.65998613
13Hepatic necrosis (HP:0002605)3.57645652
14Septo-optic dysplasia (HP:0100842)3.28210132
15Depressed nasal ridge (HP:0000457)3.25306332
16Absent thumb (HP:0009777)3.17608963
17Cerebellar dysplasia (HP:0007033)3.06983776
18Trismus (HP:0000211)3.01271206
19Hypoplasia of the pons (HP:0012110)2.85420596
20Type II lissencephaly (HP:0007260)2.84687505
21Congenital, generalized hypertrichosis (HP:0004540)2.82988369
22Colon cancer (HP:0003003)2.82019301
23Respiratory difficulties (HP:0002880)2.77540912
24Abnormality of the pons (HP:0007361)2.76177430
25Amniotic constriction ring (HP:0009775)2.72894472
26Abnormality of placental membranes (HP:0011409)2.72894472
27Thick lower lip vermilion (HP:0000179)2.69733354
28Abnormality of reticulocytes (HP:0004312)2.68728526
29Abnormality of the parietal bone (HP:0002696)2.68643391
30Abnormal number of incisors (HP:0011064)2.65598476
3111 pairs of ribs (HP:0000878)2.64304346
32Woolly hair (HP:0002224)2.64179725
33Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.64105199
34Increased muscle lipid content (HP:0009058)2.64074324
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.63589822
36Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.51167361
37Decreased activity of mitochondrial respiratory chain (HP:0008972)2.51167361
38Optic disc pallor (HP:0000543)2.48847202
39Migraine (HP:0002076)2.46044847
40Abnormality of renal resorption (HP:0011038)2.45974128
41Hypoplasia of the radius (HP:0002984)2.45814528
42Progressive muscle weakness (HP:0003323)2.45344122
43Atresia of the external auditory canal (HP:0000413)2.44681284
44Pancreatic cysts (HP:0001737)2.44250863
45Onycholysis (HP:0001806)2.41572661
46Basal cell carcinoma (HP:0002671)2.38843106
47Leukodystrophy (HP:0002415)2.37178017
48Respiratory failure (HP:0002878)2.36096992
49Increased hepatocellular lipid droplets (HP:0006565)2.34660440
50Pancreatic fibrosis (HP:0100732)2.32778028
51Triphalangeal thumb (HP:0001199)2.27750952
52Absent septum pellucidum (HP:0001331)2.27582421
53Ridged nail (HP:0001807)2.25559837
54Concave nail (HP:0001598)2.24071693
55Abnormality of midbrain morphology (HP:0002418)2.23822713
56Molar tooth sign on MRI (HP:0002419)2.23822713
57Lactic acidosis (HP:0003128)2.21423714
58Conical tooth (HP:0000698)2.18554975
59Popliteal pterygium (HP:0009756)2.16014454
60Duplication of thumb phalanx (HP:0009942)2.14674073
61Thrombocytosis (HP:0001894)2.13806119
62Pterygium (HP:0001059)2.12134839
63Sparse lateral eyebrow (HP:0005338)2.11960464
64Maternal diabetes (HP:0009800)2.11068543
65Nephronophthisis (HP:0000090)2.10485278
66True hermaphroditism (HP:0010459)2.10179083
67Hyperphosphaturia (HP:0003109)2.10038203
68Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.09970262
69Abnormality of urine glucose concentration (HP:0011016)2.09743022
70Glycosuria (HP:0003076)2.09743022
71Medial flaring of the eyebrow (HP:0010747)2.09553090
72Down-sloping shoulders (HP:0200021)2.05519874
73Bicuspid aortic valve (HP:0001647)2.04280273
74Selective tooth agenesis (HP:0001592)2.03252489
75Nasolacrimal duct obstruction (HP:0000579)2.02187156
76Sparse scalp hair (HP:0002209)2.01098394
77Abnormality of cells of the erythroid lineage (HP:0012130)11.2925882
78Rib fusion (HP:0000902)1.98896481
79Esophageal atresia (HP:0002032)1.98136415
80Horseshoe kidney (HP:0000085)1.98019160
81Congenital ichthyosiform erythroderma (HP:0007431)1.97991064
82Increased serum lactate (HP:0002151)1.97979897
83Missing ribs (HP:0000921)1.96871824
84Exertional dyspnea (HP:0002875)1.96485525
85Fragile nails (HP:0001808)1.95650940
86Retinal dysplasia (HP:0007973)1.95090104
87Abnormality of the phalanges of the 2nd finger (HP:0009541)1.94861494
88Mitochondrial inheritance (HP:0001427)1.92118567
89Oral leukoplakia (HP:0002745)1.92022368
90Exercise intolerance (HP:0003546)1.91767169
91Aplasia cutis congenita (HP:0001057)1.91428511
92Lipid accumulation in hepatocytes (HP:0006561)1.90437271
93Abnormality of the septum pellucidum (HP:0007375)1.89922513
94Natal tooth (HP:0000695)1.89609516
95Hyperglycinemia (HP:0002154)1.88780817
96Glossoptosis (HP:0000162)1.88023116
97Generalized aminoaciduria (HP:0002909)1.86167516
98Bilateral microphthalmos (HP:0007633)1.85780800
99Parakeratosis (HP:0001036)1.85733509
100Sclerocornea (HP:0000647)1.84488792
101Premature rupture of membranes (HP:0001788)1.83942564
102Hypotrichosis (HP:0001006)1.81376937
103Myokymia (HP:0002411)1.80938726
104Anophthalmia (HP:0000528)1.80289116
105Lethargy (HP:0001254)1.78763157
106Dry hair (HP:0011359)1.78158390
107Neonatal short-limb short stature (HP:0008921)1.78132056
108Multiple enchondromatosis (HP:0005701)1.75964647
109Partial duplication of the phalanx of hand (HP:0009999)1.74871296
110Mesangial abnormality (HP:0001966)1.74791463
111Facial cleft (HP:0002006)1.74419328
112Hypochromic anemia (HP:0001931)1.73965712
113Abnormality of the lacrimal duct (HP:0011481)1.73466702
114Acute necrotizing encephalopathy (HP:0006965)1.73232604
115Squamous cell carcinoma (HP:0002860)1.72905678
116Abnormal ciliary motility (HP:0012262)1.71157051
117Short nose (HP:0003196)1.71115311
118Abnormality of the renal medulla (HP:0100957)1.69991614
119Adenoma sebaceum (HP:0009720)1.68480983
120Angiofibromas (HP:0010615)1.68480983
121Cerebral edema (HP:0002181)1.66600032
122Renal Fanconi syndrome (HP:0001994)1.66057285
123Abnormal respiratory motile cilium physiology (HP:0012261)1.65931921
124Rough bone trabeculation (HP:0100670)1.64148088
125Breast hypoplasia (HP:0003187)1.61117037
126Partial duplication of thumb phalanx (HP:0009944)1.60807285
127Abnormal respiratory motile cilium morphology (HP:0005938)1.60056116
128Abnormal respiratory epithelium morphology (HP:0012253)1.60056116
129Abnormalities of placenta or umbilical cord (HP:0001194)1.58987499
130Pancytopenia (HP:0001876)1.57593505
131Biliary tract neoplasm (HP:0100574)1.56803485
132IgM deficiency (HP:0002850)1.55636701
133Increased intramyocellular lipid droplets (HP:0012240)1.55164433
134Birth length less than 3rd percentile (HP:0003561)1.55061464
135Abnormal urine phosphate concentration (HP:0012599)1.54974303
136Hypoparathyroidism (HP:0000829)1.54198205
137Supernumerary bones of the axial skeleton (HP:0009144)1.53891524
138Forearm undergrowth (HP:0009821)1.53698975
139Congenital primary aphakia (HP:0007707)1.53639170
140Chin dimple (HP:0010751)1.52838969
141Neoplasm of the pancreas (HP:0002894)1.52504925
142Testicular atrophy (HP:0000029)1.52432838
143Aplasia/hypoplasia of the uterus (HP:0008684)1.52287220
144Optic nerve hypoplasia (HP:0000609)1.51165580
145Abnormality of the middle phalanges of the toes (HP:0010183)1.50935666
146X-linked dominant inheritance (HP:0001423)1.50492970
147Abnormality of secondary sexual hair (HP:0009888)1.49850091
148Abnormality of the axillary hair (HP:0100134)1.49850091
149Abnormality of the nasolacrimal system (HP:0000614)1.49697148
150Sparse eyelashes (HP:0000653)1.48450298
151Hypoplasia of the ulna (HP:0003022)1.48051785
152Cleft eyelid (HP:0000625)1.47843890
153Asplenia (HP:0001746)1.46999276
154Hepatocellular necrosis (HP:0001404)1.45812616
155Abnormality of the incisor (HP:0000676)1.45809448
156Aplastic anemia (HP:0001915)1.45770609
157Aplasia/Hypoplasia of the ulna (HP:0006495)1.45339321
158Abnormal mitochondria in muscle tissue (HP:0008316)1.44884691
159Patellar aplasia (HP:0006443)1.44405635
160Nail dystrophy (HP:0008404)1.43492345

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.80482758
2BUB15.05545976
3EIF2AK15.03181743
4NME24.87910355
5TLK14.23682023
6RPS6KB24.15891935
7EIF2AK32.83752174
8EEF2K2.63712714
9LRRK22.50634452
10TAF12.42008003
11ZAK2.37658547
12ILK2.11510820
13WEE12.02620092
14PIM21.89038431
15CDC71.85413159
16MKNK11.83337187
17MAPKAPK31.70023342
18MST41.66007141
19NUAK11.65327979
20NME11.64995109
21SRPK11.54267819
22VRK11.53604020
23MKNK21.52984987
24FGFR21.49991963
25TGFBR11.48867500
26TXK1.46935811
27MARK31.43414322
28BCKDK1.41236755
29MAP3K101.40009373
30WNK31.38846403
31AURKB1.38142533
32CDK71.35666083
33MAPK151.33864132
34DYRK31.32178473
35EPHB21.31586822
36INSRR1.26686617
37TAOK31.21258218
38EPHA41.14951844
39NEK21.13274224
40RPS6KA41.12120416
41WNK41.10573718
42PASK1.10570248
43EPHA21.09758464
44PAK21.09230722
45PIK3CA1.08708799
46STK101.08441619
47ADRBK21.05727567
48AURKA1.02942916
49PAK11.01253355
50PLK11.01027290
51PBK0.96098187
52EIF2AK20.94005163
53GRK10.93167096
54TTK0.91333402
55TESK20.90219611
56ALK0.87633258
57MAP3K80.87182019
58MELK0.85443562
59CDK60.85349274
60BRSK10.83393384
61MAP3K40.82427666
62PAK40.80542414
63PLK40.80056566
64MUSK0.78698741
65STK160.78690839
66CDK40.77420197
67MAP3K110.76413140
68MAP4K20.75873737
69CDK90.75571562
70MST1R0.74748504
71CSNK2A20.74373051
72NLK0.74287605
73KDR0.73955225
74PKN20.73599802
75STK110.73264048
76BRSK20.72535494
77PRKCG0.71368231
78MAP3K120.67371713
79ROCK20.66659289
80MAP4K10.64941671
81PIM10.64304350
82KIT0.62749671
83CHEK20.61838731
84CDK190.61526286
85CDK30.60820386
86MAPKAPK50.60396839
87TNIK0.60358243
88CDK80.59346610
89RPS6KA50.59199632
90UHMK10.57833953
91ABL20.57695048
92CSNK2A10.57094309
93CHEK10.56584479
94DYRK1B0.55508270
95OXSR10.55053476
96PNCK0.54138944
97PRKCI0.52679010
98CAMKK20.52122654
99NEK10.51190661
100FLT30.50610165
101RPS6KC10.50316158
102RPS6KL10.50316158
103ATR0.50099244
104MAP3K30.49972908
105TYRO30.48910055
106CAMK10.48473438
107GRK60.48036339
108DYRK20.46854841
109CCNB10.46790900
110STK40.45159677
111RPS6KA10.44093782
112TEC0.43585896
113DAPK30.43269482
114ADRBK10.42023142
115GRK70.41549785
116BMPR1B0.41437619
117MOS0.41120667
118FGFR10.39942494
119CDK20.39233176
120CASK0.38315315
121STK240.38233096
122MAP2K70.38157459
123NTRK20.37671758
124ATM0.37645260
125LIMK10.37586466
126BMX0.37294587
127PRKACA0.36760673
128MATK0.36596569
129RPS6KA60.36498098
130ITK0.36410796
131MAPKAPK20.35976962
132LATS20.35477107
133CSNK1E0.35246761
134ACVR1B0.34435658
135DYRK1A0.34282077
136PRKCQ0.33232606
137MAP2K20.30127004
138STK30.29871212
139STK390.29711524
140TIE10.29488761
141PLK30.27110579
142CDK120.26763783
143CLK10.26602775
144BLK0.26543144
145IKBKB0.26165622
146CDK10.24086352
147PRKG20.23248606
148AKT20.20319585

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030109.39215386
2Proteasome_Homo sapiens_hsa030503.22476892
3DNA replication_Homo sapiens_hsa030303.04618695
4RNA polymerase_Homo sapiens_hsa030203.03151122
5Spliceosome_Homo sapiens_hsa030402.94052205
6Mismatch repair_Homo sapiens_hsa034302.88569481
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65880172
8Parkinsons disease_Homo sapiens_hsa050122.36774839
9Oxidative phosphorylation_Homo sapiens_hsa001902.36157042
10Homologous recombination_Homo sapiens_hsa034402.09520690
11RNA transport_Homo sapiens_hsa030132.06759961
12Nucleotide excision repair_Homo sapiens_hsa034201.91304960
13Pyrimidine metabolism_Homo sapiens_hsa002401.83667790
14One carbon pool by folate_Homo sapiens_hsa006701.77605594
15Huntingtons disease_Homo sapiens_hsa050161.76361455
16Cell cycle_Homo sapiens_hsa041101.58988159
17Protein export_Homo sapiens_hsa030601.55316345
18Alzheimers disease_Homo sapiens_hsa050101.54956542
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.46984011
20Base excision repair_Homo sapiens_hsa034101.43413592
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37497870
22Fanconi anemia pathway_Homo sapiens_hsa034601.35990178
23Systemic lupus erythematosus_Homo sapiens_hsa053221.34361703
24RNA degradation_Homo sapiens_hsa030181.28018277
25p53 signaling pathway_Homo sapiens_hsa041151.16885772
26Non-homologous end-joining_Homo sapiens_hsa034501.14210218
27Basal cell carcinoma_Homo sapiens_hsa052171.03572345
28Asthma_Homo sapiens_hsa053101.00818362
29Cyanoamino acid metabolism_Homo sapiens_hsa004600.95516286
30mRNA surveillance pathway_Homo sapiens_hsa030150.93665262
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87350551
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87121837
33Maturity onset diabetes of the young_Homo sapiens_hsa049500.86752941
34Basal transcription factors_Homo sapiens_hsa030220.86073237
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83486767
36Phototransduction_Homo sapiens_hsa047440.80726990
37Epstein-Barr virus infection_Homo sapiens_hsa051690.80575461
38Sulfur relay system_Homo sapiens_hsa041220.79688926
39Hedgehog signaling pathway_Homo sapiens_hsa043400.79468588
40Bladder cancer_Homo sapiens_hsa052190.78105385
41Linoleic acid metabolism_Homo sapiens_hsa005910.77664453
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72540106
43Cardiac muscle contraction_Homo sapiens_hsa042600.71987266
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71023375
45Acute myeloid leukemia_Homo sapiens_hsa052210.70992573
46Autoimmune thyroid disease_Homo sapiens_hsa053200.70575519
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69591512
48Nitrogen metabolism_Homo sapiens_hsa009100.69329699
49Purine metabolism_Homo sapiens_hsa002300.69251249
50Graft-versus-host disease_Homo sapiens_hsa053320.68577821
51MicroRNAs in cancer_Homo sapiens_hsa052060.68454502
52Allograft rejection_Homo sapiens_hsa053300.67535608
53HTLV-I infection_Homo sapiens_hsa051660.67290878
54Small cell lung cancer_Homo sapiens_hsa052220.64686475
55Alcoholism_Homo sapiens_hsa050340.64361959
56Metabolic pathways_Homo sapiens_hsa011000.61845187
57Viral carcinogenesis_Homo sapiens_hsa052030.59833419
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57397992
59Chronic myeloid leukemia_Homo sapiens_hsa052200.56695959
60Thyroid cancer_Homo sapiens_hsa052160.56152365
61Herpes simplex infection_Homo sapiens_hsa051680.54452287
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53843311
63Caffeine metabolism_Homo sapiens_hsa002320.51356900
64Antigen processing and presentation_Homo sapiens_hsa046120.51323227
65Proteoglycans in cancer_Homo sapiens_hsa052050.50249582
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49562678
67Peroxisome_Homo sapiens_hsa041460.49310117
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48934483
69Type I diabetes mellitus_Homo sapiens_hsa049400.48764007
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48610684
71Pathways in cancer_Homo sapiens_hsa052000.47855912
72Primary immunodeficiency_Homo sapiens_hsa053400.47510662
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47175393
74Vitamin digestion and absorption_Homo sapiens_hsa049770.47101004
75Chemical carcinogenesis_Homo sapiens_hsa052040.46648122
76Biosynthesis of amino acids_Homo sapiens_hsa012300.44824084
77Prostate cancer_Homo sapiens_hsa052150.44767020
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44529179
79Apoptosis_Homo sapiens_hsa042100.44523550
80Glutathione metabolism_Homo sapiens_hsa004800.44516151
81Hippo signaling pathway_Homo sapiens_hsa043900.43436843
82HIF-1 signaling pathway_Homo sapiens_hsa040660.43030545
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42611644
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42605256
85Non-small cell lung cancer_Homo sapiens_hsa052230.42464772
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42352531
87Folate biosynthesis_Homo sapiens_hsa007900.41868690
88Propanoate metabolism_Homo sapiens_hsa006400.41751350
89Collecting duct acid secretion_Homo sapiens_hsa049660.41749243
90Renal cell carcinoma_Homo sapiens_hsa052110.41709626
91Nicotine addiction_Homo sapiens_hsa050330.41356545
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.40737464
93TGF-beta signaling pathway_Homo sapiens_hsa043500.39205331
94Wnt signaling pathway_Homo sapiens_hsa043100.38903515
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.38185701
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35445707
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33367369
98Hematopoietic cell lineage_Homo sapiens_hsa046400.32900118
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32757017
100Melanoma_Homo sapiens_hsa052180.32664938
101Pyruvate metabolism_Homo sapiens_hsa006200.32580667
102Regulation of autophagy_Homo sapiens_hsa041400.31669603
103Colorectal cancer_Homo sapiens_hsa052100.30263058
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30082984
105ECM-receptor interaction_Homo sapiens_hsa045120.29065962
106Butanoate metabolism_Homo sapiens_hsa006500.28917454
107Retinol metabolism_Homo sapiens_hsa008300.28792078
108Tyrosine metabolism_Homo sapiens_hsa003500.28490062
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.28319337
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28161051
111T cell receptor signaling pathway_Homo sapiens_hsa046600.27720153
112B cell receptor signaling pathway_Homo sapiens_hsa046620.27500702
113Hepatitis B_Homo sapiens_hsa051610.26938507
114Sphingolipid metabolism_Homo sapiens_hsa006000.26681036
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26384780
116VEGF signaling pathway_Homo sapiens_hsa043700.26350602
117Tryptophan metabolism_Homo sapiens_hsa003800.25411264
118Taste transduction_Homo sapiens_hsa047420.25141894
119Pentose phosphate pathway_Homo sapiens_hsa000300.24835052
120Rheumatoid arthritis_Homo sapiens_hsa053230.24121343
121Olfactory transduction_Homo sapiens_hsa047400.23948375
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23880957
123Notch signaling pathway_Homo sapiens_hsa043300.23872002
124Shigellosis_Homo sapiens_hsa051310.22196146
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22075132
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21898423
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.21594638
128Fat digestion and absorption_Homo sapiens_hsa049750.21473111
129Arachidonic acid metabolism_Homo sapiens_hsa005900.20904191
130Viral myocarditis_Homo sapiens_hsa054160.20578564
131Glioma_Homo sapiens_hsa052140.20197956
132Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.19972761
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.19887093
134Amoebiasis_Homo sapiens_hsa051460.19610161
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.19181577
136Endometrial cancer_Homo sapiens_hsa052130.18809782
137Dorso-ventral axis formation_Homo sapiens_hsa043200.18590389
138Oocyte meiosis_Homo sapiens_hsa041140.18579103
139Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17187704
140Intestinal immune network for IgA production_Homo sapiens_hsa046720.16955915
141Adherens junction_Homo sapiens_hsa045200.16730743
142Primary bile acid biosynthesis_Homo sapiens_hsa001200.16040422
143Pancreatic cancer_Homo sapiens_hsa052120.15630857
144Tight junction_Homo sapiens_hsa045300.15376101
145Mineral absorption_Homo sapiens_hsa049780.13464088
146Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.12680963
147Ether lipid metabolism_Homo sapiens_hsa005650.12326827
148Selenocompound metabolism_Homo sapiens_hsa004500.12104656
149Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.10449678
150Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.07686066
151Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.07283370
152Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.03678297
153Serotonergic synapse_Homo sapiens_hsa047260.03526272

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