RPL31P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular anion homeostasis (GO:0030002)6.79591275
2DNA deamination (GO:0045006)6.31884181
3ribosomal small subunit assembly (GO:0000028)6.20786194
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.31801694
5positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)5.31145937
6sleep (GO:0030431)5.12212603
7heart field specification (GO:0003128)5.09025696
8secondary heart field specification (GO:0003139)5.09025696
9regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.84931992
10positive regulation of endothelial cell apoptotic process (GO:2000353)4.83430724
11regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.76300400
12positive regulation of cell fate commitment (GO:0010455)4.32218695
13ATP synthesis coupled proton transport (GO:0015986)4.26832651
14energy coupled proton transport, down electrochemical gradient (GO:0015985)4.26832651
15viral transcription (GO:0019083)4.25957305
16platelet dense granule organization (GO:0060155)4.23271129
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.14407452
18regulation of hypersensitivity (GO:0002883)4.11399531
19T-helper 1 type immune response (GO:0042088)4.02211453
20positive regulation of interleukin-17 production (GO:0032740)4.01769446
21regulation of protein glycosylation (GO:0060049)3.99538016
22L-fucose catabolic process (GO:0042355)3.96545381
23fucose catabolic process (GO:0019317)3.96545381
24L-fucose metabolic process (GO:0042354)3.96545381
25translational termination (GO:0006415)3.93302382
26chaperone-mediated protein transport (GO:0072321)3.92699726
27negative regulation of mast cell activation (GO:0033004)3.90735871
28cytidine metabolic process (GO:0046087)3.86006782
29cytidine catabolic process (GO:0006216)3.86006782
30cytidine deamination (GO:0009972)3.86006782
31behavioral response to nicotine (GO:0035095)3.84095866
32necroptotic process (GO:0070266)3.82326757
33growth hormone receptor signaling pathway (GO:0060396)3.75557036
34negative regulation of cell fate specification (GO:0009996)3.75279577
35cardiac ventricle formation (GO:0003211)3.67164207
36regulation of mesoderm development (GO:2000380)3.62643312
37cell migration involved in heart development (GO:0060973)3.60055832
38T cell apoptotic process (GO:0070231)3.58184230
39intracellular pH reduction (GO:0051452)3.58081271
40ribosomal large subunit biogenesis (GO:0042273)3.54390333
41positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.52797563
42regulation of metalloenzyme activity (GO:0048552)3.52724747
43SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.42059837
44positive regulation of ERBB signaling pathway (GO:1901186)3.40961631
45cellular response to growth hormone stimulus (GO:0071378)3.40711211
46maturation of SSU-rRNA (GO:0030490)3.40078173
47cardiac chamber formation (GO:0003207)3.37126683
48positive regulation of prostaglandin secretion (GO:0032308)3.36048998
49translational elongation (GO:0006414)3.35267428
50cotranslational protein targeting to membrane (GO:0006613)3.33887728
51GPI anchor biosynthetic process (GO:0006506)3.33458242
52immunoglobulin mediated immune response (GO:0016064)3.33235564
53specification of organ identity (GO:0010092)3.32812882
54protein targeting to ER (GO:0045047)3.31655774
55mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.22971306
56transcription from RNA polymerase I promoter (GO:0006360)3.22332431
57protein localization to endoplasmic reticulum (GO:0070972)3.19804927
58pyrimidine ribonucleoside catabolic process (GO:0046133)3.19551380
59GPI anchor metabolic process (GO:0006505)3.15004388
60transcription elongation from RNA polymerase III promoter (GO:0006385)3.14794073
61termination of RNA polymerase III transcription (GO:0006386)3.14794073
62mitochondrial respiratory chain complex I assembly (GO:0032981)3.13296167
63NADH dehydrogenase complex assembly (GO:0010257)3.13296167
64mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.13296167
65chaperone mediated protein folding requiring cofactor (GO:0051085)3.09436499
66establishment of protein localization to endoplasmic reticulum (GO:0072599)3.08870384
67programmed necrotic cell death (GO:0097300)3.04340783
68ncRNA 3-end processing (GO:0043628)3.04119426
69regulation of interleukin-8 secretion (GO:2000482)3.03673843
70ribosomal small subunit biogenesis (GO:0042274)3.03650806
71positive regulation of fibroblast migration (GO:0010763)3.02211676
72preassembly of GPI anchor in ER membrane (GO:0016254)3.01504579
73lymphocyte apoptotic process (GO:0070227)3.00512945
74activated T cell proliferation (GO:0050798)3.00395125
75positive regulation of calcium-mediated signaling (GO:0050850)2.93884104
76pH reduction (GO:0045851)2.91142328
77negative regulation of cell fate commitment (GO:0010454)2.90724919
78tyrosine phosphorylation of STAT protein (GO:0007260)2.90281927
79cell wall macromolecule metabolic process (GO:0044036)2.90046608
80positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.89739953
81water-soluble vitamin biosynthetic process (GO:0042364)2.89342259
82respiratory electron transport chain (GO:0022904)2.89312265
83viral life cycle (GO:0019058)2.88366526
84positive regulation of alpha-beta T cell proliferation (GO:0046641)2.87190391
85electron transport chain (GO:0022900)2.86304201
86purinergic nucleotide receptor signaling pathway (GO:0035590)2.85982599
87cytokine biosynthetic process (GO:0042089)2.84577425
88positive regulation of defense response to virus by host (GO:0002230)2.83400673
89B cell mediated immunity (GO:0019724)2.82540421
90cell wall macromolecule catabolic process (GO:0016998)2.82318376
91negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.79191065
92positive regulation of mast cell activation involved in immune response (GO:0033008)2.77252973
93positive regulation of mast cell degranulation (GO:0043306)2.77252973
94cellular protein complex disassembly (GO:0043624)2.76226109
95regulation of alpha-beta T cell proliferation (GO:0046640)2.76135483
96positive regulation of mast cell activation (GO:0033005)2.76134205
97protein complex biogenesis (GO:0070271)2.75342533
98G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.74358986
99positive regulation of protein homodimerization activity (GO:0090073)2.74131126
100ATP biosynthetic process (GO:0006754)2.72545459

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.55271826
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.44706684
3FLI1_27457419_Chip-Seq_LIVER_Mouse3.12834202
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.07594809
5VDR_22108803_ChIP-Seq_LS180_Human3.07181020
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.99440950
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.97814514
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.61452256
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.56954486
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.50607100
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.42159197
12ZNF274_21170338_ChIP-Seq_K562_Hela2.21898522
13PCGF2_27294783_Chip-Seq_NPCs_Mouse2.17747705
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.15117691
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.14685961
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12564666
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.06739908
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.02671526
19IGF1R_20145208_ChIP-Seq_DFB_Human1.96228828
20NFE2_27457419_Chip-Seq_LIVER_Mouse1.84742194
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.80680247
22RUNX_20019798_ChIP-Seq_JUKART_Human1.79286102
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79156595
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77131520
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.76028481
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.73775242
27GATA3_26560356_Chip-Seq_TH2_Human1.72527441
28TAF2_19829295_ChIP-Seq_ESCs_Human1.62854416
29VDR_23849224_ChIP-Seq_CD4+_Human1.56158160
30EZH2_22144423_ChIP-Seq_EOC_Human1.55965872
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.52439770
32PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.49081068
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.46710878
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46378202
35TP53_22573176_ChIP-Seq_HFKS_Human1.44133770
36GATA3_21878914_ChIP-Seq_MCF-7_Human1.42665547
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41928013
38AR_20517297_ChIP-Seq_VCAP_Human1.37805143
39TDRD3_21172665_ChIP-Seq_MCF-7_Human1.37035316
40ER_23166858_ChIP-Seq_MCF-7_Human1.35593892
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.35181883
42TAF15_26573619_Chip-Seq_HEK293_Human1.34463660
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.34087028
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31705215
45FUS_26573619_Chip-Seq_HEK293_Human1.31621644
46TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.31376040
47FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29465541
48FOXA1_25329375_ChIP-Seq_VCAP_Human1.29465541
49MYC_18940864_ChIP-ChIP_HL60_Human1.29210413
50SOX2_19829295_ChIP-Seq_ESCs_Human1.28638447
51NANOG_19829295_ChIP-Seq_ESCs_Human1.28638447
52P53_21459846_ChIP-Seq_SAOS-2_Human1.27508717
53PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.27203735
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.24715832
55FOXH1_21741376_ChIP-Seq_EPCs_Human1.22667709
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22431415
57EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.22207012
58EWS_26573619_Chip-Seq_HEK293_Human1.20441615
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.20329411
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.20072504
61AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19645287
62FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19302898
63IRF8_21731497_ChIP-ChIP_J774_Mouse1.19059182
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18872740
65ERG_20517297_ChIP-Seq_VCAP_Human1.17759732
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.17109966
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14266014
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13340988
69ERA_21632823_ChIP-Seq_H3396_Human1.12141908
70GATA3_26560356_Chip-Seq_TH1_Human1.12023813
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11251178
72P300_19829295_ChIP-Seq_ESCs_Human1.10498527
73CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09405216
74IRF1_19129219_ChIP-ChIP_H3396_Human1.08372442
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.07329810
76GATA3_27048872_Chip-Seq_THYMUS_Human1.02411288
77HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02312226
78GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.02075405
79ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01507643
80E2F1_20622854_ChIP-Seq_HELA_Human1.01433180
81IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01039807
82KAP1_22055183_ChIP-Seq_ESCs_Mouse1.00057271
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99808997
84MYC_19829295_ChIP-Seq_ESCs_Human0.99478262
85FOXP3_21729870_ChIP-Seq_TREG_Human0.97391863
86SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96143248
87RNF2_27304074_Chip-Seq_NSC_Mouse0.95598167
88GATA6_21074721_ChIP-Seq_CACO-2_Human0.95218321
89SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94910428
90CTCF_20526341_ChIP-Seq_ESCs_Human0.94645589
91RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94486220
92ELK1_19687146_ChIP-ChIP_HELA_Human0.94034054
93BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93787146
94GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92636213
95GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91737108
96P53_22387025_ChIP-Seq_ESCs_Mouse0.90457851
97CTCF_18555785_Chip-Seq_ESCs_Mouse0.90296801
98SPI1_20517297_ChIP-Seq_HL60_Human0.90088902
99STAT3_18555785_Chip-Seq_ESCs_Mouse0.89342220
100RBPJ_21746931_ChIP-Seq_IB4_Human0.89218105

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002234_abnormal_pharynx_morphology4.97042894
2MP0001835_abnormal_antigen_presentation3.49118986
3MP0001873_stomach_inflammation3.30905580
4MP0005671_abnormal_response_to2.90514958
5MP0006082_CNS_inflammation2.77769291
6MP0005646_abnormal_pituitary_gland2.75911344
7MP0009379_abnormal_foot_pigmentation2.68813241
8MP0006292_abnormal_olfactory_placode2.60676016
9MP0001529_abnormal_vocalization2.59823509
10MP0003724_increased_susceptibility_to2.59312421
11MP0003646_muscle_fatigue2.47649215
12MP0008875_abnormal_xenobiotic_pharmacok2.42116289
13MP0004147_increased_porphyrin_level2.40408968
14MP0006072_abnormal_retinal_apoptosis2.27885138
15MP0008872_abnormal_physiological_respon2.09614166
16MP0000465_gastrointestinal_hemorrhage1.99730890
17MP0001905_abnormal_dopamine_level1.97805605
18MP0001800_abnormal_humoral_immune1.96713740
19MP0002148_abnormal_hypersensitivity_rea1.94243974
20MP0005253_abnormal_eye_physiology1.93150081
21MP0002933_joint_inflammation1.88663983
22MP0004142_abnormal_muscle_tone1.86084651
23MP0005000_abnormal_immune_tolerance1.73442360
24MP0003011_delayed_dark_adaptation1.64414595
25MP0002452_abnormal_antigen_presenting1.58974912
26MP0002876_abnormal_thyroid_physiology1.56375117
27MP0002723_abnormal_immune_serum1.55575583
28MP0002822_catalepsy1.54963610
29MP0001986_abnormal_taste_sensitivity1.46432616
30MP0000569_abnormal_digit_pigmentation1.46341352
31MP0005551_abnormal_eye_electrophysiolog1.45208790
32MP0000230_abnormal_systemic_arterial1.41219968
33MP0009046_muscle_twitch1.36252875
34MP0005360_urolithiasis1.28814120
35MP0005025_abnormal_response_to1.27490542
36MP0001819_abnormal_immune_cell1.24431512
37MP0002420_abnormal_adaptive_immunity1.23648088
38MP0002419_abnormal_innate_immunity1.21670967
39MP0009785_altered_susceptibility_to1.21508538
40MP0004885_abnormal_endolymph1.18714917
41MP0003195_calcinosis1.18227124
42MP0002736_abnormal_nociception_after1.16907547
43MP0000372_irregular_coat_pigmentation1.16469992
44MP0008995_early_reproductive_senescence1.13821979
45MP0000685_abnormal_immune_system1.12825708
46MP0001968_abnormal_touch/_nociception1.11794326
47MP0008775_abnormal_heart_ventricle1.08477468
48MP0008469_abnormal_protein_level1.08448992
49MP0001790_abnormal_immune_system1.07831028
50MP0005387_immune_system_phenotype1.07831028
51MP0001663_abnormal_digestive_system1.07624813
52MP0001845_abnormal_inflammatory_respons1.05771785
53MP0010386_abnormal_urinary_bladder1.05239919
54MP0002163_abnormal_gland_morphology1.03480394
55MP0002272_abnormal_nervous_system1.03014209
56MP0002138_abnormal_hepatobiliary_system1.01757058
57MP0001851_eye_inflammation0.99803162
58MP0001765_abnormal_ion_homeostasis0.98969621
59MP0004130_abnormal_muscle_cell0.95663513
60MP0005645_abnormal_hypothalamus_physiol0.95638983
61MP0009745_abnormal_behavioral_response0.95308316
62MP0006276_abnormal_autonomic_nervous0.94647608
63MP0003638_abnormal_response/metabolism_0.92929672
64MP0003075_altered_response_to0.92705337
65MP0005367_renal/urinary_system_phenotyp0.92031804
66MP0000516_abnormal_urinary_system0.92031804
67MP0005075_abnormal_melanosome_morpholog0.91835847
68MP0008877_abnormal_DNA_methylation0.90530359
69MP0004145_abnormal_muscle_electrophysio0.88427223
70MP0008058_abnormal_DNA_repair0.86705955
71MP0005166_decreased_susceptibility_to0.86002085
72MP0002277_abnormal_respiratory_mucosa0.85547148
73MP0001440_abnormal_grooming_behavior0.85533968
74MP0006036_abnormal_mitochondrial_physio0.84725185
75MP0009764_decreased_sensitivity_to0.82662687
76MP0002837_dystrophic_cardiac_calcinosis0.81806308
77MP0000716_abnormal_immune_system0.81108259
78MP0005636_abnormal_mineral_homeostasis0.80155134
79MP0005195_abnormal_posterior_eye0.80118452
80MP0003950_abnormal_plasma_membrane0.79382849
81MP0010155_abnormal_intestine_physiology0.78477425
82MP0003436_decreased_susceptibility_to0.78252843
83MP0004924_abnormal_behavior0.78047588
84MP0005386_behavior/neurological_phenoty0.78047588
85MP0000013_abnormal_adipose_tissue0.77693456
86MP0005084_abnormal_gallbladder_morpholo0.76381296
87MP0003787_abnormal_imprinting0.75740931
88MP0008873_increased_physiological_sensi0.75666743
89MP0001970_abnormal_pain_threshold0.74166065
90MP0005595_abnormal_vascular_smooth0.74114243
91MP0002572_abnormal_emotion/affect_behav0.74098677
92MP0005389_reproductive_system_phenotype0.73533299
93MP0005381_digestive/alimentary_phenotyp0.73320700
94MP0009333_abnormal_splenocyte_physiolog0.73064962
95MP0002095_abnormal_skin_pigmentation0.72823977
96MP0003866_abnormal_defecation0.71123984
97MP0001486_abnormal_startle_reflex0.70952383
98MP0005085_abnormal_gallbladder_physiolo0.70071040
99MP0001664_abnormal_digestion0.68814288
100MP0005391_vision/eye_phenotype0.66047590

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune thrombocytopenia (HP:0001973)7.36027219
2Autoimmune hemolytic anemia (HP:0001890)6.17339159
3Increased IgM level (HP:0003496)5.93515014
4Abnormal delayed hypersensitivity skin test (HP:0002963)5.73235203
5Decreased activity of mitochondrial respiratory chain (HP:0008972)4.48182221
6Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.48182221
7Eosinophilia (HP:0001880)4.33598217
8Hypochromic anemia (HP:0001931)3.84118320
9Abnormality of T cell number (HP:0011839)3.83992729
10Birth length less than 3rd percentile (HP:0003561)3.77990776
11Anterior segment dysgenesis (HP:0007700)3.60618593
12Type II lissencephaly (HP:0007260)3.60116149
13Recurrent gram-negative bacterial infections (HP:0005420)3.56655437
14Acute necrotizing encephalopathy (HP:0006965)3.42553814
15Abnormality of eosinophils (HP:0001879)3.40362284
16Enlarged epiphyses (HP:0010580)3.39601038
17Granulocytopenia (HP:0001913)3.37604627
18Myotonia (HP:0002486)3.30645252
19Leukocytosis (HP:0001974)3.27609071
20Lip pit (HP:0100267)3.14971908
21Cerebellar dysplasia (HP:0007033)3.10342744
22Agammaglobulinemia (HP:0004432)3.09095971
23Abnormality of T cell physiology (HP:0011840)3.08067451
24Congenital stationary night blindness (HP:0007642)3.02933124
25Abnormal mitochondria in muscle tissue (HP:0008316)2.98980772
26Progressive macrocephaly (HP:0004481)2.97618302
27Congenital, generalized hypertrichosis (HP:0004540)2.96793846
28Hepatocellular necrosis (HP:0001404)2.88928620
29Acute encephalopathy (HP:0006846)2.86680873
30Mitochondrial inheritance (HP:0001427)2.86623672
31Neonatal hypoglycemia (HP:0001998)2.76696899
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.64657818
33Type 2 muscle fiber atrophy (HP:0003554)2.63727441
34Vasculitis (HP:0002633)2.59355146
35Increased CSF lactate (HP:0002490)2.58515967
36Glucose intolerance (HP:0000833)2.49331325
37Hepatic necrosis (HP:0002605)2.43667787
38Abolished electroretinogram (ERG) (HP:0000550)2.43229675
39Attenuation of retinal blood vessels (HP:0007843)2.40112184
40Depressed nasal tip (HP:0000437)2.36536892
41Insulin-resistant diabetes mellitus (HP:0000831)2.34896222
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.33113019
43Chin dimple (HP:0010751)2.30287675
44Muscle fiber atrophy (HP:0100295)2.30279486
45Abnormality of T cells (HP:0002843)2.28614062
46IgG deficiency (HP:0004315)2.28371343
47Decreased electroretinogram (ERG) amplitude (HP:0000654)2.24347416
48Pancreatic cysts (HP:0001737)2.24233973
49Hypergammaglobulinemia (HP:0010702)2.23179027
503-Methylglutaconic aciduria (HP:0003535)2.18848315
51Hypothermia (HP:0002045)2.18338292
52Reticulocytopenia (HP:0001896)2.14601587
53Molar tooth sign on MRI (HP:0002419)2.14303297
54Abnormality of midbrain morphology (HP:0002418)2.14303297
55Urticaria (HP:0001025)2.11394930
56Hypoproteinemia (HP:0003075)2.09635021
57Periodontitis (HP:0000704)2.09312403
58Recurrent abscess formation (HP:0002722)2.07193252
59Methylmalonic acidemia (HP:0002912)2.07103297
60Cerebral edema (HP:0002181)2.06286064
61Abnormality of the prostate (HP:0008775)2.04438861
62Neutropenia (HP:0001875)2.03945173
63Chronic bronchitis (HP:0004469)2.02345528
64Lipid accumulation in hepatocytes (HP:0006561)2.01699540
65Decreased central vision (HP:0007663)2.00555659
66Increased hepatocellular lipid droplets (HP:0006565)1.99392938
67Hyperglycemia (HP:0003074)1.97724361
68Sparse lateral eyebrow (HP:0005338)1.96915392
69Abnormality of the columella (HP:0009929)1.96515007
70Cerebral palsy (HP:0100021)1.96421211
71Abnormality of cells of the erythroid lineage (HP:0012130)1.95883904
72Nephronophthisis (HP:0000090)1.94931396
73Meningitis (HP:0001287)1.93308841
74Respiratory failure (HP:0002878)1.92676914
75Optic disc pallor (HP:0000543)1.91514458
76Abnormal glucose tolerance (HP:0001952)1.90590496
77Stomatitis (HP:0010280)1.89765851
78Alveolar cell carcinoma (HP:0006519)1.89274400
79Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.88892400
80Fatigable weakness (HP:0003473)1.88233404
81Abnormality of the neuromuscular junction (HP:0003398)1.88233404
82Constricted visual fields (HP:0001133)1.87936698
83Elevated erythrocyte sedimentation rate (HP:0003565)1.87541831
84True hermaphroditism (HP:0010459)1.87109210
85Pancreatic fibrosis (HP:0100732)1.84678074
86B lymphocytopenia (HP:0010976)1.83425546
87Hyperglycinemia (HP:0002154)1.82634539
88Epileptic encephalopathy (HP:0200134)1.81894787
89Hypomagnesemia (HP:0002917)1.80481006
90Lethargy (HP:0001254)1.80019121
91Pendular nystagmus (HP:0012043)1.79479305
92Abnormality of B cell number (HP:0010975)1.79184774
93Abnormality of magnesium homeostasis (HP:0004921)1.75839593
94Ectropion (HP:0000656)1.75616305
95Abnormal respiratory motile cilium physiology (HP:0012261)1.75335338
96Abnormality of macular pigmentation (HP:0008002)1.74079077
97Abnormal number of erythroid precursors (HP:0012131)1.73325759
98Abnormal rod and cone electroretinograms (HP:0008323)1.73160517
99Increased corneal curvature (HP:0100692)1.72179400
100Keratoconus (HP:0000563)1.72179400

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK18.18073014
2PIK3CA4.60876940
3CDK194.07975652
4MAP4K23.75195774
5TAOK33.23383095
6BMPR22.97132360
7KIT2.16024468
8TXK2.13588960
9GRK11.94764765
10CAMKK21.92767031
11FES1.87776128
12FRK1.77378031
13PRKCH1.69855859
14ADRBK21.64417754
15MAP4K11.60884384
16OXSR11.58405855
17ZAK1.44863426
18MAP2K61.35062876
19GRK61.17431293
20PBK1.11783979
21MAP3K61.09577713
22TIE11.09065939
23SYK1.08703924
24CAMK1D1.07131912
25ERBB31.06729840
26LCK1.02158117
27IKBKB1.01374727
28MAPK121.00516159
29PINK11.00354568
30GRK70.99498988
31PRKCG0.98628784
32DAPK10.98422816
33ADRBK10.95289005
34MATK0.86954867
35WNK40.84339361
36INSRR0.84326587
37RIPK40.84039338
38NUAK10.81482623
39TEC0.78592476
40MAP3K120.77937265
41STK160.77667396
42CSF1R0.77129584
43LYN0.76879722
44RET0.76673157
45MINK10.73045163
46PHKG10.72502417
47PHKG20.72502417
48BCKDK0.71029361
49ILK0.70553259
50PRKCQ0.68964904
51JAK30.67968785
52TRPM70.67966400
53PKN10.66274758
54MAP2K30.65251048
55MYLK0.63901924
56TYRO30.63087721
57GRK50.62414627
58PIK3CG0.60178282
59CAMKK10.58047905
60IGF1R0.57058607
61FLT30.54441990
62ITK0.54384128
63ZAP700.53647971
64BTK0.53518692
65NME10.51475500
66DAPK20.48529250
67MAPK130.47578983
68OBSCN0.47147148
69WNK30.46041008
70PRKCD0.45096168
71SCYL20.44386968
72CAMK10.44265180
73MARK30.43944469
74PRKACA0.43257381
75CAMK2A0.43160951
76MAP2K20.43075110
77PDGFRB0.42879109
78STK110.41933660
79RPS6KA50.41652024
80KDR0.39990152
81MOS0.39933959
82PLK40.39497221
83PRKCA0.38490831
84CSK0.37644147
85MAP2K40.37284427
86PRKG10.37151568
87ABL10.36010870
88MAPK150.34776512
89DAPK30.33824955
90ERBB20.33613350
91CSNK1G30.31339512
92TNK20.30641880
93CSNK2A20.28784568
94MAPKAPK50.27817665
95HCK0.27411933
96NME20.26272929
97MKNK10.24855470
98CSNK1G10.24797820
99PRKCB0.24524606
100PRKACG0.23394595

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.78339717
2Autoimmune thyroid disease_Homo sapiens_hsa053204.62186997
3Graft-versus-host disease_Homo sapiens_hsa053324.54476113
4Asthma_Homo sapiens_hsa053104.17703277
5Type I diabetes mellitus_Homo sapiens_hsa049404.07408928
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.08916551
7RNA polymerase_Homo sapiens_hsa030202.97060588
8Ribosome_Homo sapiens_hsa030102.70740031
9Caffeine metabolism_Homo sapiens_hsa002322.34970467
10Oxidative phosphorylation_Homo sapiens_hsa001902.23566575
11Staphylococcus aureus infection_Homo sapiens_hsa051502.23290410
12Rheumatoid arthritis_Homo sapiens_hsa053232.10116914
13Viral myocarditis_Homo sapiens_hsa054162.06974203
14African trypanosomiasis_Homo sapiens_hsa051432.03941739
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.97915922
16Parkinsons disease_Homo sapiens_hsa050121.97299920
17Linoleic acid metabolism_Homo sapiens_hsa005911.96142009
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.85338171
19Leishmaniasis_Homo sapiens_hsa051401.64690820
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.56978342
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50545880
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50026942
23Phototransduction_Homo sapiens_hsa047441.43746960
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.41300906
25Antigen processing and presentation_Homo sapiens_hsa046121.39193653
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32144462
27Primary immunodeficiency_Homo sapiens_hsa053401.21986293
28Malaria_Homo sapiens_hsa051441.14964708
29Alzheimers disease_Homo sapiens_hsa050101.13412681
30Homologous recombination_Homo sapiens_hsa034401.10728845
31Proteasome_Homo sapiens_hsa030501.09273926
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08295893
33Arachidonic acid metabolism_Homo sapiens_hsa005901.07265538
34Cardiac muscle contraction_Homo sapiens_hsa042601.05582610
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00256032
36Huntingtons disease_Homo sapiens_hsa050160.99761856
37Legionellosis_Homo sapiens_hsa051340.99088212
38Systemic lupus erythematosus_Homo sapiens_hsa053220.90023416
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83245919
40Pyrimidine metabolism_Homo sapiens_hsa002400.77817424
41Olfactory transduction_Homo sapiens_hsa047400.75763022
42Chemical carcinogenesis_Homo sapiens_hsa052040.73047998
43Purine metabolism_Homo sapiens_hsa002300.72531371
44Protein export_Homo sapiens_hsa030600.72359651
45Pertussis_Homo sapiens_hsa051330.70765372
46Nitrogen metabolism_Homo sapiens_hsa009100.67596271
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66376049
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63774707
49Influenza A_Homo sapiens_hsa051640.60807939
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60454099
51One carbon pool by folate_Homo sapiens_hsa006700.60225696
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58692610
53Hematopoietic cell lineage_Homo sapiens_hsa046400.58505362
54Fat digestion and absorption_Homo sapiens_hsa049750.57247162
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55732620
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55311033
57Tuberculosis_Homo sapiens_hsa051520.54685924
58Ether lipid metabolism_Homo sapiens_hsa005650.53358953
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51817217
60Nucleotide excision repair_Homo sapiens_hsa034200.51627908
61Tryptophan metabolism_Homo sapiens_hsa003800.48937935
62Vitamin B6 metabolism_Homo sapiens_hsa007500.46493850
63Measles_Homo sapiens_hsa051620.45301043
64Pentose phosphate pathway_Homo sapiens_hsa000300.43189310
65Herpes simplex infection_Homo sapiens_hsa051680.40737832
66Glycerolipid metabolism_Homo sapiens_hsa005610.39778985
67Retinol metabolism_Homo sapiens_hsa008300.38384041
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35614775
69Toxoplasmosis_Homo sapiens_hsa051450.35349660
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32550582
71Fanconi anemia pathway_Homo sapiens_hsa034600.31475944
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.31287025
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.30959976
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30435707
75Salivary secretion_Homo sapiens_hsa049700.30395916
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29338644
77Basal transcription factors_Homo sapiens_hsa030220.28263590
78RNA degradation_Homo sapiens_hsa030180.27945233
79Collecting duct acid secretion_Homo sapiens_hsa049660.24036283
80Nicotine addiction_Homo sapiens_hsa050330.23884638
81RNA transport_Homo sapiens_hsa030130.23341105
82Taste transduction_Homo sapiens_hsa047420.23193379
83Phagosome_Homo sapiens_hsa041450.22987568
84Glutathione metabolism_Homo sapiens_hsa004800.21927821
85Spliceosome_Homo sapiens_hsa030400.20922241
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.20894579
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20780776
88Metabolic pathways_Homo sapiens_hsa011000.20069038
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.19248702
90Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.18737396
91Mismatch repair_Homo sapiens_hsa034300.18640412
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.18016680
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.17065346
94Peroxisome_Homo sapiens_hsa041460.15932935
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.15800580
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.12380361
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.12055081
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.10897974
99T cell receptor signaling pathway_Homo sapiens_hsa046600.10654410
100Epstein-Barr virus infection_Homo sapiens_hsa051690.10429455

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