ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	7.71297793
2	translational termination (GO:0006415)	7.39497104
3	ribosomal small subunit assembly (GO:0000028)	6.99600783
4	translational elongation (GO:0006414)	6.36448559
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.23991954
6	cotranslational protein targeting to membrane (GO:0006613)	6.16145554
7	protein targeting to ER (GO:0045047)	6.13208882
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.06041617
9	ATP synthesis coupled proton transport (GO:0015986)	6.06041617
10	ribosomal small subunit biogenesis (GO:0042274)	6.05286109
11	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.85146879
12	protein localization to endoplasmic reticulum (GO:0070972)	5.76882996
13	maturation of SSU-rRNA (GO:0030490)	5.73758148
14	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.73495896
15	chaperone-mediated protein transport (GO:0072321)	5.61821666
16	cellular protein complex disassembly (GO:0043624)	5.54199634
17	viral life cycle (GO:0019058)	5.52035858
18	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.18735442
19	translational initiation (GO:0006413)	4.81973110
20	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.78842576
21	protein complex biogenesis (GO:0070271)	4.78453613
22	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.70938124
23	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.70938124
24	behavioral response to nicotine (GO:0035095)	4.65433497
25	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.62233674
26	protein complex disassembly (GO:0043241)	4.59698903
27	mitochondrial respiratory chain complex assembly (GO:0033108)	4.50569684
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.49750746
29	NADH dehydrogenase complex assembly (GO:0010257)	4.49750746
30	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.49750746
31	respiratory electron transport chain (GO:0022904)	4.38521619
32	electron transport chain (GO:0022900)	4.35658204
33	macromolecular complex disassembly (GO:0032984)	4.33457216
34	translation (GO:0006412)	4.28044585
35	ribosomal large subunit biogenesis (GO:0042273)	4.26054866
36	protein neddylation (GO:0045116)	4.24918138
37	protein targeting to membrane (GO:0006612)	4.10330127
38	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.07664109
39	DNA deamination (GO:0045006)	4.04990274
40	protein-cofactor linkage (GO:0018065)	3.72733464
41	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.63841984
42	nucleotide salvage (GO:0043173)	3.58430576
43	ATP biosynthetic process (GO:0006754)	3.47156383
44	CTP biosynthetic process (GO:0006241)	3.43666787
45	CTP metabolic process (GO:0046036)	3.43666787
46	water-soluble vitamin biosynthetic process (GO:0042364)	3.43594035
47	mRNA catabolic process (GO:0006402)	3.43537695
48	cellular component biogenesis (GO:0044085)	3.41206393
49	respiratory chain complex IV assembly (GO:0008535)	3.41081233
50	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.40731649
51	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.40503503
52	hydrogen ion transmembrane transport (GO:1902600)	3.36581037
53	pyrimidine nucleotide catabolic process (GO:0006244)	3.33420866
54	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.33212917
55	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.26207720
56	cytochrome complex assembly (GO:0017004)	3.20249583
57	GTP biosynthetic process (GO:0006183)	3.19436050
58	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.16660710
59	RNA catabolic process (GO:0006401)	3.14611548
60	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.09091634
61	ribonucleoprotein complex biogenesis (GO:0022613)	3.08441872
62	purine nucleotide salvage (GO:0032261)	3.08145686
63	tRNA processing (GO:0008033)	3.04608205
64	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.03776712
65	nucleoside salvage (GO:0043174)	3.03320762
66	proton transport (GO:0015992)	3.02380060
67	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.99675345
68	hydrogen transport (GO:0006818)	2.96688406
69	base-excision repair, AP site formation (GO:0006285)	2.95105980
70	nucleoside triphosphate biosynthetic process (GO:0009142)	2.94348520
71	tRNA modification (GO:0006400)	2.90792246
72	termination of RNA polymerase III transcription (GO:0006386)	2.89449059
73	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.89449059
74	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.85548959
75	intracellular protein transmembrane import (GO:0044743)	2.85152173
76	establishment of protein localization to membrane (GO:0090150)	2.82847998
77	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.82252738
78	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	2.77246310
79	protein targeting to mitochondrion (GO:0006626)	2.76785862
80	substrate-independent telencephalic tangential migration (GO:0021826)	2.75276942
81	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.75276942
82	rRNA processing (GO:0006364)	2.74983938
83	rRNA metabolic process (GO:0016072)	2.74897252
84	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	2.73825921
85	protein targeting (GO:0006605)	2.72636601
86	establishment of protein localization to mitochondrion (GO:0072655)	2.68803789
87	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.66451176
88	UTP biosynthetic process (GO:0006228)	2.66067541
89	UTP metabolic process (GO:0046051)	2.63194913
90	pseudouridine synthesis (GO:0001522)	2.57791442
91	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.53335415
92	protein localization to mitochondrion (GO:0070585)	2.52399886
93	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.50080570
94	deoxyribonucleotide catabolic process (GO:0009264)	2.49303818
95	establishment of protein localization to organelle (GO:0072594)	2.49231429
96	pyrimidine nucleotide biosynthetic process (GO:0006221)	2.48839409
97	preassembly of GPI anchor in ER membrane (GO:0016254)	2.46809757
98	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	2.45159997
99	UMP biosynthetic process (GO:0006222)	2.45159997
100	UMP metabolic process (GO:0046049)	2.45159997

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.24650767
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.77711854
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.65155009
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.01893072
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.98099778
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.86240150
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.79678721
8	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.74167206
9	VDR_22108803_ChIP-Seq_LS180_Human	2.62879234
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.48082284
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.41169651
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.38763661
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.24929132
14	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.14451152
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.03514688
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.84996062
17	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.83628848
18	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.82057041
19	FOXP3_21729870_ChIP-Seq_TREG_Human	1.75577212
20	TP53_22573176_ChIP-Seq_HFKS_Human	1.75082689
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.70553451
22	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.70065815
23	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.69040450
24	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.65957280
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.65925863
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.65556623
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.64369860
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.61774794
29	ELK1_19687146_ChIP-ChIP_HELA_Human	1.60984109
30	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.60886399
31	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.54367455
32	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.53110568
33	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.50751781
34	FUS_26573619_Chip-Seq_HEK293_Human	1.50623961
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49151243
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.46932683
37	EWS_26573619_Chip-Seq_HEK293_Human	1.39872062
38	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.38814705
39	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.32251614
40	TTF2_22483619_ChIP-Seq_HELA_Human	1.31671201
41	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.30706428
42	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.30336273
43	RNF2_27304074_Chip-Seq_NSC_Mouse	1.29856296
44	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.28227113
45	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.27483322
46	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.25877424
47	NCOR_22424771_ChIP-Seq_293T_Human	1.25628886
48	TAF2_19829295_ChIP-Seq_ESCs_Human	1.23700227
49	AR_20517297_ChIP-Seq_VCAP_Human	1.21847475
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21617650
51	XRN2_22483619_ChIP-Seq_HELA_Human	1.21046184
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.20862076
53	REST_21632747_ChIP-Seq_MESCs_Mouse	1.18192299
54	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.18127648
55	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.18000243
56	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.17308758
57	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.16376547
58	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.15342143
59	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.14798342
60	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.13278512
61	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.12910030
62	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.12408488
63	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.11622343
64	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.11375517
65	ERA_21632823_ChIP-Seq_H3396_Human	1.10922197
66	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.10909683
67	NANOG_20526341_ChIP-Seq_ESCs_Human	1.09995561
68	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.09277583
69	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.09072462
70	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.07793231
71	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.06664491
72	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.05552522
73	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.04483813
74	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04292946
75	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.03995034
76	MYC_19829295_ChIP-Seq_ESCs_Human	1.03820453
77	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.03289527
78	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.02846635
79	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.02846635
80	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.02822078
81	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.02338703
82	STAT1_20625510_ChIP-Seq_HELA_Human	1.02219785
83	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.01638012
84	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.01622169
85	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.00990418
86	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.00132713
87	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98973737
88	CTCF_20526341_ChIP-Seq_ESCs_Human	0.98861647
89	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98554980
90	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.97889160
91	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.97710887
92	P300_19829295_ChIP-Seq_ESCs_Human	0.97691262
93	IGF1R_20145208_ChIP-Seq_DFB_Human	0.97488999
94	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.96154337
95	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.95133882
96	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.95133882
97	* NANOG_19829295_ChIP-Seq_ESCs_Human	0.94393073
98	* SOX2_19829295_ChIP-Seq_ESCs_Human	0.94393073
99	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.93788487
100	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.93553211

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.90877886
2	MP0006292_abnormal_olfactory_placode	3.58397053
3	MP0002163_abnormal_gland_morphology	3.15509625
4	MP0005646_abnormal_pituitary_gland	3.04665026
5	MP0003646_muscle_fatigue	2.72529746
6	MP0002837_dystrophic_cardiac_calcinosis	2.22427156
7	MP0004885_abnormal_endolymph	2.22320314
8	MP0002138_abnormal_hepatobiliary_system	2.11708352
9	MP0006072_abnormal_retinal_apoptosis	2.02874950
10	MP0005379_endocrine/exocrine_gland_phen	1.96694022
11	MP0002234_abnormal_pharynx_morphology	1.90104827
12	MP0005360_urolithiasis	1.87331162
13	MP0008872_abnormal_physiological_respon	1.83640404
14	MP0001968_abnormal_touch/_nociception	1.82235014
15	MP0004142_abnormal_muscle_tone	1.81450335
16	MP0005671_abnormal_response_to	1.80982880
17	MP0002736_abnormal_nociception_after	1.80581991
18	MP0005551_abnormal_eye_electrophysiolog	1.79362125
19	MP0001905_abnormal_dopamine_level	1.75649417
20	MP0008875_abnormal_xenobiotic_pharmacok	1.72786872
21	MP0004147_increased_porphyrin_level	1.71890644
22	MP0003806_abnormal_nucleotide_metabolis	1.71764304
23	MP0004145_abnormal_muscle_electrophysio	1.67306932
24	MP0002876_abnormal_thyroid_physiology	1.67095610
25	MP0008995_early_reproductive_senescence	1.58409945
26	MP0008877_abnormal_DNA_methylation	1.56851226
27	MP0009745_abnormal_behavioral_response	1.51229398
28	MP0005084_abnormal_gallbladder_morpholo	1.50160008
29	MP0003787_abnormal_imprinting	1.49857470
30	MP0002638_abnormal_pupillary_reflex	1.45266313
31	MP0001986_abnormal_taste_sensitivity	1.44379811
32	MP0002272_abnormal_nervous_system	1.42318267
33	MP0005645_abnormal_hypothalamus_physiol	1.36504168
34	MP0000049_abnormal_middle_ear	1.36286489
35	MP0003011_delayed_dark_adaptation	1.33154009
36	MP0006276_abnormal_autonomic_nervous	1.33012386
37	MP0002160_abnormal_reproductive_system	1.30671303
38	MP0003724_increased_susceptibility_to	1.30317452
39	MP0005389_reproductive_system_phenotype	1.29692882
40	MP0002102_abnormal_ear_morphology	1.27565048
41	MP0003880_abnormal_central_pattern	1.27022445
42	MP0000631_abnormal_neuroendocrine_gland	1.25896016
43	MP0005423_abnormal_somatic_nervous	1.25517181
44	MP0002938_white_spotting	1.24758142
45	MP0002095_abnormal_skin_pigmentation	1.23072032
46	MP0009046_muscle_twitch	1.18365631
47	MP0000372_irregular_coat_pigmentation	1.15654648
48	MP0001919_abnormal_reproductive_system	1.10384617
49	MP0008789_abnormal_olfactory_epithelium	1.05414526
50	MP0002822_catalepsy	1.05297893
51	MP0003186_abnormal_redox_activity	1.04642283
52	MP0002733_abnormal_thermal_nociception	1.03807038
53	MP0006036_abnormal_mitochondrial_physio	1.00907238
54	MP0001440_abnormal_grooming_behavior	1.00312668
55	MP0003786_premature_aging	1.00236445
56	MP0005670_abnormal_white_adipose	1.00194207
57	MP0009764_decreased_sensitivity_to	1.00139544
58	MP0005253_abnormal_eye_physiology	0.99394238
59	MP0008775_abnormal_heart_ventricle	0.98067429
60	MP0002735_abnormal_chemical_nociception	0.97379389
61	MP0001293_anophthalmia	0.97348090
62	MP0002277_abnormal_respiratory_mucosa	0.97173964
63	MP0005332_abnormal_amino_acid	0.95430149
64	MP0001970_abnormal_pain_threshold	0.95200496
65	MP0005195_abnormal_posterior_eye	0.94696470
66	MP0003878_abnormal_ear_physiology	0.94371267
67	MP0005377_hearing/vestibular/ear_phenot	0.94371267
68	MP0005367_renal/urinary_system_phenotyp	0.94159252
69	MP0000516_abnormal_urinary_system	0.94159252
70	MP0004742_abnormal_vestibular_system	0.92160982
71	MP0004043_abnormal_pH_regulation	0.92036149
72	MP0001835_abnormal_antigen_presentation	0.91506601
73	MP0001485_abnormal_pinna_reflex	0.90632631
74	MP0003315_abnormal_perineum_morphology	0.90158991
75	MP0003938_abnormal_ear_development	0.88591071
76	MP0001486_abnormal_startle_reflex	0.88558133
77	MP0002572_abnormal_emotion/affect_behav	0.88461448
78	MP0003567_abnormal_fetal_cardiomyocyte	0.86220612
79	MP0002148_abnormal_hypersensitivity_rea	0.85206037
80	MP0000026_abnormal_inner_ear	0.84563596
81	MP0003123_paternal_imprinting	0.84013739
82	MP0001188_hyperpigmentation	0.83490811
83	MP0001800_abnormal_humoral_immune	0.82725185
84	MP0002653_abnormal_ependyma_morphology	0.81341169
85	MP0002064_seizures	0.81336263
86	MP0005174_abnormal_tail_pigmentation	0.80901137
87	MP0002557_abnormal_social/conspecific_i	0.80485512
88	MP0000613_abnormal_salivary_gland	0.80286722
89	MP0001963_abnormal_hearing_physiology	0.78178826
90	MP0000230_abnormal_systemic_arterial	0.77174364
91	MP0003638_abnormal_response/metabolism_	0.76566191
92	MP0002752_abnormal_somatic_nervous	0.76354190
93	MP0001348_abnormal_lacrimal_gland	0.76064004
94	MP0003136_yellow_coat_color	0.75659571
95	MP0003635_abnormal_synaptic_transmissio	0.75019766
96	MP0001502_abnormal_circadian_rhythm	0.74371529
97	MP0001790_abnormal_immune_system	0.72860940
98	MP0005387_immune_system_phenotype	0.72860940
99	MP0001663_abnormal_digestive_system	0.71507601
100	MP0001756_abnormal_urination	0.71507460

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.66561467
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.24621665
3	Mitochondrial inheritance (HP:0001427)	4.20780006
4	Abnormality of cells of the erythroid lineage (HP:0012130)	4.08925496
5	Acute encephalopathy (HP:0006846)	3.94767749
6	Progressive macrocephaly (HP:0004481)	3.85415208
7	Reticulocytopenia (HP:0001896)	3.71298531
8	Increased CSF lactate (HP:0002490)	3.70388129
9	Abnormal number of erythroid precursors (HP:0012131)	3.64657752
10	Lipid accumulation in hepatocytes (HP:0006561)	3.62160548
11	Increased hepatocellular lipid droplets (HP:0006565)	3.55785039
12	Macrocytic anemia (HP:0001972)	3.53536950
13	Congenital, generalized hypertrichosis (HP:0004540)	3.51988039
14	3-Methylglutaconic aciduria (HP:0003535)	3.49637571
15	Abnormality of midbrain morphology (HP:0002418)	3.36705817
16	Molar tooth sign on MRI (HP:0002419)	3.36705817
17	Hepatocellular necrosis (HP:0001404)	3.36108074
18	Congenital stationary night blindness (HP:0007642)	3.35264886
19	Pancreatic fibrosis (HP:0100732)	3.33517281
20	Pancreatic cysts (HP:0001737)	3.25002219
21	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.13593322
22	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.13593322
23	Hepatic necrosis (HP:0002605)	3.09504120
24	Renal Fanconi syndrome (HP:0001994)	3.08180906
25	Cerebral edema (HP:0002181)	3.01863067
26	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.98972162
27	Hyperalaninemia (HP:0003348)	2.94164260
28	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.94164260
29	Abnormality of alanine metabolism (HP:0010916)	2.94164260
30	Increased intramyocellular lipid droplets (HP:0012240)	2.88659471
31	True hermaphroditism (HP:0010459)	2.82340128
32	Pallor (HP:0000980)	2.79074312
33	Pendular nystagmus (HP:0012043)	2.77961821
34	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.72917789
35	Abnormal rod and cone electroretinograms (HP:0008323)	2.70855664
36	Lactic acidosis (HP:0003128)	2.65845374
37	Increased muscle lipid content (HP:0009058)	2.64372610
38	Nephronophthisis (HP:0000090)	2.57024227
39	Exertional dyspnea (HP:0002875)	2.56709078
40	Methylmalonic acidemia (HP:0002912)	2.54083682
41	Increased serum lactate (HP:0002151)	2.49337275
42	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.48336482
43	Optic disc pallor (HP:0000543)	2.45471069
44	Hyperglycinemia (HP:0002154)	2.42389113
45	Abolished electroretinogram (ERG) (HP:0000550)	2.37357087
46	Methylmalonic aciduria (HP:0012120)	2.30010144
47	Absent thumb (HP:0009777)	2.29705816
48	Abnormality of urine glucose concentration (HP:0011016)	2.25868161
49	Glycosuria (HP:0003076)	2.25868161
50	Stenosis of the external auditory canal (HP:0000402)	2.25593455
51	Respiratory failure (HP:0002878)	2.25412335
52	Absent/shortened dynein arms (HP:0200106)	2.22955366
53	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.22955366
54	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.22724149
55	Abnormality of renal resorption (HP:0011038)	2.22621372
56	Sclerocornea (HP:0000647)	2.19979438
57	Medial flaring of the eyebrow (HP:0010747)	2.16174314
58	Abnormality of the renal medulla (HP:0100957)	2.15362963
59	Lethargy (HP:0001254)	2.14154661
60	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.11663820
61	Type II lissencephaly (HP:0007260)	2.11394169
62	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.10034051
63	Constricted visual fields (HP:0001133)	2.08148775
64	Asplenia (HP:0001746)	2.07354364
65	Abnormality of the renal cortex (HP:0011035)	2.06306649
66	Abnormal drinking behavior (HP:0030082)	2.04829784
67	Polydipsia (HP:0001959)	2.04829784
68	Aplasia/hypoplasia of the uterus (HP:0008684)	2.03235621
69	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.02890998
70	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.01400689
71	IgG deficiency (HP:0004315)	1.99943998
72	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.99067276
73	Abnormality of the middle phalanges of the toes (HP:0010183)	1.98631230
74	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.98574168
75	Hyperphosphaturia (HP:0003109)	1.97311620
76	Increased corneal curvature (HP:0100692)	1.96743696
77	Keratoconus (HP:0000563)	1.96743696
78	Exercise intolerance (HP:0003546)	1.96129305
79	Leukodystrophy (HP:0002415)	1.94373722
80	Myokymia (HP:0002411)	1.94117466
81	Abnormal respiratory epithelium morphology (HP:0012253)	1.93792384
82	Abnormal respiratory motile cilium morphology (HP:0005938)	1.93792384
83	Hypoplasia of the uterus (HP:0000013)	1.93248091
84	Cystic liver disease (HP:0006706)	1.93206672
85	Respiratory difficulties (HP:0002880)	1.90685892
86	Generalized aminoaciduria (HP:0002909)	1.88641693
87	Abnormal biliary tract physiology (HP:0012439)	1.86306473
88	Bile duct proliferation (HP:0001408)	1.86306473
89	Abnormality of serum amino acid levels (HP:0003112)	1.82861545
90	Opisthotonus (HP:0002179)	1.82393498
91	Type 2 muscle fiber atrophy (HP:0003554)	1.81884064
92	Anencephaly (HP:0002323)	1.81411014
93	Delayed CNS myelination (HP:0002188)	1.80449943
94	Decreased central vision (HP:0007663)	1.79321246
95	Chronic hepatic failure (HP:0100626)	1.79274933
96	Chorioretinal atrophy (HP:0000533)	1.79084246
97	Hypoplasia of the ulna (HP:0003022)	1.77895257
98	Progressive microcephaly (HP:0000253)	1.71682249
99	Elevated erythrocyte sedimentation rate (HP:0003565)	1.71298838
100	Male pseudohermaphroditism (HP:0000037)	1.70021788

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	3.95693226
2	BCKDK	3.60718840
3	TAOK3	3.53054329
4	TLK1	3.16205328
5	MAP4K2	2.81552080
6	ADRBK2	2.53860204
7	GRK1	2.49453097
8	CDK19	2.41285043
9	TIE1	2.15762382
10	BMPR1B	2.07077835
11	WNK4	2.00812586
12	ZAK	1.91728853
13	TXK	1.87583883
14	VRK2	1.86753344
15	LIMK1	1.84760136
16	NUAK1	1.77895535
17	DYRK2	1.77090982
18	PHKG1	1.77021102
19	PHKG2	1.77021102
20	FRK	1.67075423
21	PINK1	1.54649257
22	NME2	1.51540555
23	WNK3	1.30363253
24	MUSK	1.20983785
25	IKBKB	1.19757906
26	TEC	1.14310742
27	OXSR1	1.09829619
28	VRK1	1.08161392
29	INSRR	1.06656456
30	NME1	1.03938059
31	ADRBK1	1.03676046
32	MAP2K2	1.03562116
33	MAP4K1	0.99692147
34	STK39	0.95561313
35	PRKCG	0.93032372
36	PRKCQ	0.90190433
37	PIK3CA	0.88913199
38	CAMKK2	0.87652241
39	MAPK13	0.87130608
40	ITK	0.86253344
41	GRK6	0.85119922
42	MAP3K12	0.84775632
43	DAPK2	0.84765223
44	PLK4	0.84627858
45	CASK	0.81740329
46	KDR	0.81727114
47	GRK5	0.79788042
48	NTRK2	0.78762610
49	MAP2K7	0.77641998
50	MAPK15	0.75075099
51	ABL2	0.74989031
52	CSNK1G3	0.74208594
53	CSNK1G1	0.73589593
54	PLK2	0.73192475
55	FES	0.72992384
56	EPHB2	0.72548884
57	CDC7	0.72428608
58	LRRK2	0.71559458
59	CSNK1G2	0.71188724
60	SYK	0.70959284
61	RPS6KA5	0.70439004
62	KIT	0.70430914
63	ILK	0.68997079
64	LYN	0.68879040
65	CSNK2A2	0.66247052
66	BUB1	0.65898337
67	CSNK1A1	0.64123264
68	DAPK1	0.63402299
69	IKBKE	0.61616368
70	GRK7	0.61531862
71	MATK	0.61529811
72	DAPK3	0.60963597
73	AURKA	0.60626468
74	PRKACA	0.59639571
75	BMPR2	0.59458488
76	PDK2	0.55601925
77	ACVR1B	0.55544588
78	OBSCN	0.55038621
79	MINK1	0.53382020
80	CSNK2A1	0.51686206
81	CSNK1A1L	0.51566813
82	TESK2	0.51444067
83	MYLK	0.51074969
84	PRKCA	0.50445884
85	CAMK1	0.50308081
86	PRKCD	0.50077231
87	MAP3K4	0.49740104
88	MAPKAPK5	0.47419985
89	PKN1	0.47150607
90	MAP2K6	0.46101381
91	PRKCI	0.44949274
92	CAMK2A	0.43113056
93	PASK	0.42742865
94	SIK2	0.42500348
95	PRKCE	0.42350684
96	TAF1	0.41877560
97	BTK	0.41465410
98	CDK8	0.40878722
99	LCK	0.39995092
100	SGK223	0.38146250

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.21073955
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.33372954
3	Parkinsons disease_Homo sapiens_hsa05012	3.51317827
4	Sulfur relay system_Homo sapiens_hsa04122	3.35203675
5	Asthma_Homo sapiens_hsa05310	2.67823933
6	Alzheimers disease_Homo sapiens_hsa05010	2.49605365
7	Huntingtons disease_Homo sapiens_hsa05016	2.26884865
8	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.21537111
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.18740072
10	Cardiac muscle contraction_Homo sapiens_hsa04260	2.18281339
11	Proteasome_Homo sapiens_hsa03050	2.05836243
12	Allograft rejection_Homo sapiens_hsa05330	2.04591529
13	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.99244609
14	RNA polymerase_Homo sapiens_hsa03020	1.98921912
15	Graft-versus-host disease_Homo sapiens_hsa05332	1.93158897
16	Protein export_Homo sapiens_hsa03060	1.81231380
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.80319518
18	Phototransduction_Homo sapiens_hsa04744	1.67197179
19	Type I diabetes mellitus_Homo sapiens_hsa04940	1.61782499
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.60409602
21	Homologous recombination_Homo sapiens_hsa03440	1.58506021
22	One carbon pool by folate_Homo sapiens_hsa00670	1.48142114
23	Pyrimidine metabolism_Homo sapiens_hsa00240	1.35053160
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.31667101
25	RNA degradation_Homo sapiens_hsa03018	1.23613339
26	Primary immunodeficiency_Homo sapiens_hsa05340	1.22016424
27	Collecting duct acid secretion_Homo sapiens_hsa04966	1.17686762
28	Rheumatoid arthritis_Homo sapiens_hsa05323	1.16769383
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.16598249
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.13569183
31	Nicotine addiction_Homo sapiens_hsa05033	1.13377204
32	Sulfur metabolism_Homo sapiens_hsa00920	1.10590810
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.07064946
34	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.05288269
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.05194962
36	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.02250344
37	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.99307537
38	Fanconi anemia pathway_Homo sapiens_hsa03460	0.90910500
39	Olfactory transduction_Homo sapiens_hsa04740	0.85812211
40	Morphine addiction_Homo sapiens_hsa05032	0.85778076
41	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.85248053
42	Antigen processing and presentation_Homo sapiens_hsa04612	0.85083623
43	Purine metabolism_Homo sapiens_hsa00230	0.84419669
44	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.79334651
45	DNA replication_Homo sapiens_hsa03030	0.78230532
46	Retinol metabolism_Homo sapiens_hsa00830	0.76127207
47	Basal transcription factors_Homo sapiens_hsa03022	0.75661354
48	Tryptophan metabolism_Homo sapiens_hsa00380	0.75288264
49	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.74403677
50	Chemical carcinogenesis_Homo sapiens_hsa05204	0.74147864
51	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.74002982
52	Peroxisome_Homo sapiens_hsa04146	0.72873200
53	Folate biosynthesis_Homo sapiens_hsa00790	0.71774661
54	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.70145408
55	Caffeine metabolism_Homo sapiens_hsa00232	0.68557616
56	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.67759033
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66754851
58	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.66105106
59	Fat digestion and absorption_Homo sapiens_hsa04975	0.65763559
60	Nucleotide excision repair_Homo sapiens_hsa03420	0.65677902
61	Spliceosome_Homo sapiens_hsa03040	0.65595236
62	Propanoate metabolism_Homo sapiens_hsa00640	0.64295321
63	Metabolic pathways_Homo sapiens_hsa01100	0.63919630
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.63447383
65	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.61459796
66	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.61281576
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59975264
68	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.59622775
69	Regulation of autophagy_Homo sapiens_hsa04140	0.57380947
70	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.56828443
71	Mismatch repair_Homo sapiens_hsa03430	0.56372639
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56097405
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.55860411
74	Base excision repair_Homo sapiens_hsa03410	0.55201250
75	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.53237259
76	Taste transduction_Homo sapiens_hsa04742	0.52160651
77	Serotonergic synapse_Homo sapiens_hsa04726	0.51800896
78	GABAergic synapse_Homo sapiens_hsa04727	0.51310169
79	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.50306489
80	Ether lipid metabolism_Homo sapiens_hsa00565	0.49437625
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.48385081
82	Butanoate metabolism_Homo sapiens_hsa00650	0.48124760
83	Selenocompound metabolism_Homo sapiens_hsa00450	0.47343376
84	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.45629847
85	Viral myocarditis_Homo sapiens_hsa05416	0.44755368
86	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.43364374
87	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.42796738
88	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.39844097
89	RNA transport_Homo sapiens_hsa03013	0.38964479
90	Circadian entrainment_Homo sapiens_hsa04713	0.37115717
91	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.35260275
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.34292572
93	Salivary secretion_Homo sapiens_hsa04970	0.32705754
94	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.31054195
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.28158014
96	beta-Alanine metabolism_Homo sapiens_hsa00410	0.24597575
97	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.24493229
98	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.24484494
99	Insulin secretion_Homo sapiens_hsa04911	0.21557541
100	Glutamatergic synapse_Homo sapiens_hsa04724	0.18795291

RPL31P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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