ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ATP synthesis coupled proton transport (GO:0015986)	5.83471696
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.83471696
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.34149215
4	ribosomal small subunit assembly (GO:0000028)	5.17930236
5	ribosomal small subunit biogenesis (GO:0042274)	4.84449350
6	maturation of SSU-rRNA (GO:0030490)	4.75545380
7	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.66951554
8	protein complex biogenesis (GO:0070271)	4.57939943
9	cytochrome complex assembly (GO:0017004)	4.41936401
10	respiratory chain complex IV assembly (GO:0008535)	4.41164021
11	viral transcription (GO:0019083)	4.30650786
12	DNA deamination (GO:0045006)	4.27902234
13	mitochondrial respiratory chain complex assembly (GO:0033108)	4.22891779
14	respiratory electron transport chain (GO:0022904)	4.19218834
15	electron transport chain (GO:0022900)	4.17354651
16	translational termination (GO:0006415)	4.07511539
17	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.99392136
18	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.99392136
19	NADH dehydrogenase complex assembly (GO:0010257)	3.99392136
20	preassembly of GPI anchor in ER membrane (GO:0016254)	3.97711619
21	behavioral response to nicotine (GO:0035095)	3.96370711
22	chaperone-mediated protein transport (GO:0072321)	3.68042878
23	ATP biosynthetic process (GO:0006754)	3.67083571
24	negative regulation of telomere maintenance (GO:0032205)	3.66693860
25	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.66594810
26	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.54658409
27	translational elongation (GO:0006414)	3.49164252
28	water-soluble vitamin biosynthetic process (GO:0042364)	3.49122360
29	protein targeting to ER (GO:0045047)	3.48947739
30	pseudouridine synthesis (GO:0001522)	3.48776741
31	cotranslational protein targeting to membrane (GO:0006613)	3.47436529
32	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.42724024
33	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.41770150
34	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.41770150
35	hydrogen ion transmembrane transport (GO:1902600)	3.36376446
36	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.33376834
37	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.29973611
38	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.29518083
39	protein localization to endoplasmic reticulum (GO:0070972)	3.23707039
40	proton transport (GO:0015992)	3.19469993
41	hydrogen transport (GO:0006818)	3.15015226
42	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	3.13064794
43	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.10037509
44	ribosomal large subunit biogenesis (GO:0042273)	3.09031993
45	viral life cycle (GO:0019058)	3.08050606
46	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.07940936
47	cellular component biogenesis (GO:0044085)	3.06067982
48	positive regulation of prostaglandin secretion (GO:0032308)	3.03222678
49	cellular protein complex disassembly (GO:0043624)	3.03047824
50	protein neddylation (GO:0045116)	3.02302674
51	intracellular protein transmembrane import (GO:0044743)	3.02031826
52	piRNA metabolic process (GO:0034587)	3.00858512
53	cilium or flagellum-dependent cell motility (GO:0001539)	3.00462678
54	aldehyde catabolic process (GO:0046185)	2.98803561
55	translation (GO:0006412)	2.97021571
56	maturation of 5.8S rRNA (GO:0000460)	2.96808787
57	male meiosis (GO:0007140)	2.96726365
58	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.95937275
59	positive regulation of fatty acid transport (GO:2000193)	2.94607910
60	activated T cell proliferation (GO:0050798)	2.94530434
61	translational initiation (GO:0006413)	2.91722449
62	mannosylation (GO:0097502)	2.90794138
63	inner mitochondrial membrane organization (GO:0007007)	2.89152518
64	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.86532980
65	axonemal dynein complex assembly (GO:0070286)	2.85141712
66	mast cell degranulation (GO:0043303)	2.84265020
67	mast cell activation involved in immune response (GO:0002279)	2.84265020
68	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.83110640
69	protein polyglutamylation (GO:0018095)	2.81228642
70	fucose catabolic process (GO:0019317)	2.80652347
71	L-fucose metabolic process (GO:0042354)	2.80652347
72	L-fucose catabolic process (GO:0042355)	2.80652347
73	GPI anchor biosynthetic process (GO:0006506)	2.73244115
74	GMP metabolic process (GO:0046037)	2.72297658
75	cellular ketone body metabolic process (GO:0046950)	2.70849531
76	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.70376988
77	arginine metabolic process (GO:0006525)	2.68651934
78	GPI anchor metabolic process (GO:0006505)	2.67987558
79	axoneme assembly (GO:0035082)	2.67266467
80	negative regulation of heart rate (GO:0010459)	2.64992079
81	myoblast migration (GO:0051451)	2.64626164
82	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.63255733
83	positive regulation of icosanoid secretion (GO:0032305)	2.63063227
84	rRNA processing (GO:0006364)	2.62854968
85	rRNA metabolic process (GO:0016072)	2.59679649
86	positive regulation of protein homodimerization activity (GO:0090073)	2.59171749
87	neuronal action potential propagation (GO:0019227)	2.57941539
88	regulation of action potential (GO:0098900)	2.54222074
89	positive regulation of respiratory burst (GO:0060267)	2.54173410
90	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.49771426
91	peptidyl-histidine modification (GO:0018202)	2.49571194
92	platelet dense granule organization (GO:0060155)	2.49333323
93	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.49242664
94	ribonucleoprotein complex biogenesis (GO:0022613)	2.47917397
95	mast cell activation (GO:0045576)	2.47424797
96	protein peptidyl-prolyl isomerization (GO:0000413)	2.46675904
97	forebrain morphogenesis (GO:0048853)	2.45381453
98	nucleoside triphosphate biosynthetic process (GO:0009142)	2.44847343
99	positive regulation of response to tumor cell (GO:0002836)	2.44450425
100	regulation of immune response to tumor cell (GO:0002837)	2.44450425

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.72664321
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.48712708
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.40040318
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.37598618
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.92164081
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.82327951
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.78972217
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.56655270
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.53431701
10	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.49435328
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.29725330
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.15543809
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.13746573
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.05404656
15	VDR_22108803_ChIP-Seq_LS180_Human	1.92376854
16	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.90474729
17	VDR_23849224_ChIP-Seq_CD4+_Human	1.87471310
18	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.83949192
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.80405381
20	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.76444471
21	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.70698086
22	EWS_26573619_Chip-Seq_HEK293_Human	1.69380059
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.66353306
24	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.61597175
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.61221820
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.59601474
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.48327337
28	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.47088099
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.46919894
30	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.46015038
31	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.44000050
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.43291659
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.41094796
34	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.39921569
35	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.38596255
36	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.35723202
37	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.32560602
38	TTF2_22483619_ChIP-Seq_HELA_Human	1.32080734
39	ER_23166858_ChIP-Seq_MCF-7_Human	1.32049608
40	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.31648012
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.30554066
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.30554066
43	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.30301900
44	ERA_21632823_ChIP-Seq_H3396_Human	1.29918345
45	FOXP3_21729870_ChIP-Seq_TREG_Human	1.29913314
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25782999
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25782999
48	P300_19829295_ChIP-Seq_ESCs_Human	1.25343237
49	ELK1_19687146_ChIP-ChIP_HELA_Human	1.25032880
50	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.24222341
51	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.23458001
52	IGF1R_20145208_ChIP-Seq_DFB_Human	1.20775628
53	TAF2_19829295_ChIP-Seq_ESCs_Human	1.19963921
54	AR_20517297_ChIP-Seq_VCAP_Human	1.17760815
55	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.17705848
56	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.17639540
57	GATA3_26560356_Chip-Seq_TH2_Human	1.17520536
58	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.16407040
59	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.16362290
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.15722553
61	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.12726558
62	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.12008781
63	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.10569680
64	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.10542142
65	REST_21632747_ChIP-Seq_MESCs_Mouse	1.10490855
66	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.10417661
67	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.09559912
68	NANOG_20526341_ChIP-Seq_ESCs_Human	1.09328370
69	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.09202942
70	MYC_19829295_ChIP-Seq_ESCs_Human	1.08400489
71	GABP_19822575_ChIP-Seq_HepG2_Human	1.07978407
72	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.07083373
73	NCOR_22424771_ChIP-Seq_293T_Human	1.06525444
74	STAT1_20625510_ChIP-Seq_HELA_Human	1.05781523
75	CIITA_25753668_ChIP-Seq_RAJI_Human	1.05586693
76	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.04392359
77	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.03789062
78	FUS_26573619_Chip-Seq_HEK293_Human	1.02672049
79	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.01383769
80	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.98861671
81	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.98706591
82	P53_21459846_ChIP-Seq_SAOS-2_Human	0.98165840
83	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.97771342
84	RNF2_27304074_Chip-Seq_NSC_Mouse	0.95578013
85	HOXB7_26014856_ChIP-Seq_BT474_Human	0.94701319
86	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94085828
87	IRF1_19129219_ChIP-ChIP_H3396_Human	0.93388614
88	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.92316444
89	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.92239023
90	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.91984591
91	E2F1_20622854_ChIP-Seq_HELA_Human	0.91482064
92	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.90942790
93	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.90224990
94	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.89767045
95	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.89588076
96	CBP_20019798_ChIP-Seq_JUKART_Human	0.89588076
97	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89141353
98	PHF8_20622853_ChIP-Seq_HELA_Human	0.89024949
99	RBPJ_21746931_ChIP-Seq_IB4_Human	0.88667285
100	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.86191121

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002163_abnormal_gland_morphology	4.68639164
2	MP0002138_abnormal_hepatobiliary_system	4.00004934
3	MP0009379_abnormal_foot_pigmentation	3.15713422
4	MP0002102_abnormal_ear_morphology	3.01303953
5	MP0008875_abnormal_xenobiotic_pharmacok	2.83903991
6	MP0005379_endocrine/exocrine_gland_phen	2.80838005
7	MP0006292_abnormal_olfactory_placode	2.78820148
8	MP0003646_muscle_fatigue	2.65778734
9	MP0008872_abnormal_physiological_respon	2.64133687
10	MP0005646_abnormal_pituitary_gland	2.58817015
11	MP0005084_abnormal_gallbladder_morpholo	2.51545813
12	MP0002876_abnormal_thyroid_physiology	2.49798251
13	MP0004142_abnormal_muscle_tone	2.41332193
14	MP0003136_yellow_coat_color	2.36556072
15	MP0003183_abnormal_peptide_metabolism	2.19264491
16	MP0008877_abnormal_DNA_methylation	2.17948853
17	MP0002277_abnormal_respiratory_mucosa	1.96699167
18	MP0004147_increased_porphyrin_level	1.90479004
19	MP0002837_dystrophic_cardiac_calcinosis	1.86959676
20	MP0005551_abnormal_eye_electrophysiolog	1.85329700
21	MP0000685_abnormal_immune_system	1.78310570
22	MP0001968_abnormal_touch/_nociception	1.72873742
23	MP0003787_abnormal_imprinting	1.70610366
24	MP0005167_abnormal_blood-brain_barrier	1.70213240
25	MP0001835_abnormal_antigen_presentation	1.67476326
26	MP0001986_abnormal_taste_sensitivity	1.64354853
27	MP0005645_abnormal_hypothalamus_physiol	1.57982926
28	MP0003252_abnormal_bile_duct	1.44423802
29	MP0002095_abnormal_skin_pigmentation	1.43915450
30	MP0002272_abnormal_nervous_system	1.43839568
31	MP0001188_hyperpigmentation	1.43164165
32	MP0001348_abnormal_lacrimal_gland	1.41741738
33	MP0005085_abnormal_gallbladder_physiolo	1.38486751
34	MP0002733_abnormal_thermal_nociception	1.37737562
35	MP0002928_abnormal_bile_duct	1.32692080
36	MP0001346_abnormal_lacrimal_gland	1.30655433
37	MP0001293_anophthalmia	1.27666833
38	MP0009333_abnormal_splenocyte_physiolog	1.26225856
39	MP0006072_abnormal_retinal_apoptosis	1.22546131
40	MP0003186_abnormal_redox_activity	1.21442726
41	MP0005174_abnormal_tail_pigmentation	1.20763086
42	MP0001970_abnormal_pain_threshold	1.20001155
43	MP0004043_abnormal_pH_regulation	1.17199016
44	MP0003122_maternal_imprinting	1.15483415
45	MP0008058_abnormal_DNA_repair	1.13554194
46	MP0001873_stomach_inflammation	1.12670915
47	MP0000015_abnormal_ear_pigmentation	1.12623080
48	MP0003121_genomic_imprinting	1.11762147
49	MP0001485_abnormal_pinna_reflex	1.11507889
50	MP0005389_reproductive_system_phenotype	1.08968140
51	MP0001663_abnormal_digestive_system	1.07487482
52	MP0001502_abnormal_circadian_rhythm	1.06229113
53	MP0001800_abnormal_humoral_immune	1.05522167
54	MP0005671_abnormal_response_to	1.05165859
55	MP0005387_immune_system_phenotype	1.02833570
56	MP0001790_abnormal_immune_system	1.02833570
57	MP0002160_abnormal_reproductive_system	1.02241510
58	MP0009745_abnormal_behavioral_response	0.99123814
59	MP0009046_muscle_twitch	0.98832179
60	MP0002254_reproductive_system_inflammat	0.97694593
61	MP0010030_abnormal_orbit_morphology	0.96897835
62	MP0006036_abnormal_mitochondrial_physio	0.96086120
63	MP0002638_abnormal_pupillary_reflex	0.95208821
64	MP0005195_abnormal_posterior_eye	0.94544191
65	MP0009764_decreased_sensitivity_to	0.91308423
66	MP0002938_white_spotting	0.91101081
67	MP0001501_abnormal_sleep_pattern	0.90320968
68	MP0004885_abnormal_endolymph	0.89776639
69	MP0002148_abnormal_hypersensitivity_rea	0.88737064
70	MP0001919_abnormal_reproductive_system	0.88280370
71	MP0006082_CNS_inflammation	0.87210558
72	MP0004019_abnormal_vitamin_homeostasis	0.85236974
73	MP0001764_abnormal_homeostasis	0.84068895
74	MP0008775_abnormal_heart_ventricle	0.83459353
75	MP0005253_abnormal_eye_physiology	0.83310337
76	MP0000230_abnormal_systemic_arterial	0.82574089
77	MP0002909_abnormal_adrenal_gland	0.82377653
78	MP0004381_abnormal_hair_follicle	0.81697778
79	MP0004742_abnormal_vestibular_system	0.79764072
80	MP0005365_abnormal_bile_salt	0.77566162
81	MP0001765_abnormal_ion_homeostasis	0.76879283
82	MP0005636_abnormal_mineral_homeostasis	0.75770168
83	MP0005410_abnormal_fertilization	0.75634328
84	MP0001756_abnormal_urination	0.75441663
85	MP0004145_abnormal_muscle_electrophysio	0.74938118
86	MP0006276_abnormal_autonomic_nervous	0.74304807
87	MP0005220_abnormal_exocrine_pancreas	0.70314751
88	MP0002210_abnormal_sex_determination	0.70304659
89	MP0002736_abnormal_nociception_after	0.70048665
90	MP0005670_abnormal_white_adipose	0.69703903
91	MP0003195_calcinosis	0.68759213
92	MP0000647_abnormal_sebaceous_gland	0.68688645
93	MP0002229_neurodegeneration	0.68342106
94	MP0001984_abnormal_olfaction	0.66973276
95	MP0009785_altered_susceptibility_to	0.66166465
96	MP0002693_abnormal_pancreas_physiology	0.65307167
97	MP0006035_abnormal_mitochondrial_morpho	0.65085183
98	MP0003866_abnormal_defecation	0.64913487
99	MP0000653_abnormal_sex_gland	0.64734276
100	MP0002234_abnormal_pharynx_morphology	0.64607855

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Mitochondrial inheritance (HP:0001427)	4.24990287
2	Acute necrotizing encephalopathy (HP:0006965)	4.24422264
3	Lipid accumulation in hepatocytes (HP:0006561)	4.10037527
4	Increased CSF lactate (HP:0002490)	4.06045803
5	Increased hepatocellular lipid droplets (HP:0006565)	3.83506244
6	Reticulocytopenia (HP:0001896)	3.81297830
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.74922359
8	Progressive macrocephaly (HP:0004481)	3.53449490
9	Acute encephalopathy (HP:0006846)	3.51819564
10	Abnormality of cells of the erythroid lineage (HP:0012130)	3.47166694
11	Nephronophthisis (HP:0000090)	3.38636897
12	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.37456742
13	Absent/shortened dynein arms (HP:0200106)	3.37456742
14	Abnormality of midbrain morphology (HP:0002418)	3.34037818
15	Molar tooth sign on MRI (HP:0002419)	3.34037818
16	Renal Fanconi syndrome (HP:0001994)	3.21905806
17	Hepatocellular necrosis (HP:0001404)	3.18162609
18	Congenital stationary night blindness (HP:0007642)	3.16606787
19	Abnormal rod and cone electroretinograms (HP:0008323)	3.14222794
20	Pancreatic cysts (HP:0001737)	2.98281787
21	Congenital, generalized hypertrichosis (HP:0004540)	2.85256489
22	Abnormality of the renal medulla (HP:0100957)	2.83896307
23	Hepatic necrosis (HP:0002605)	2.81166506
24	Testicular atrophy (HP:0000029)	2.76688452
25	Hypomagnesemia (HP:0002917)	2.76274796
26	Stenosis of the external auditory canal (HP:0000402)	2.69512156
27	Increased intramyocellular lipid droplets (HP:0012240)	2.67160498
28	Cerebral edema (HP:0002181)	2.65572593
29	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.63121677
30	Abnormality of magnesium homeostasis (HP:0004921)	2.62041535
31	Abolished electroretinogram (ERG) (HP:0000550)	2.58073848
32	Increased muscle lipid content (HP:0009058)	2.56828992
33	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.55547989
34	True hermaphroditism (HP:0010459)	2.51726836
35	Increased serum lactate (HP:0002151)	2.51618861
36	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.50905320
37	B lymphocytopenia (HP:0010976)	2.49769314
38	Abnormal respiratory epithelium morphology (HP:0012253)	2.46116989
39	Abnormal respiratory motile cilium morphology (HP:0005938)	2.46116989
40	Pancreatic fibrosis (HP:0100732)	2.45050087
41	Exertional dyspnea (HP:0002875)	2.44282667
42	Abnormal number of erythroid precursors (HP:0012131)	2.40509210
43	Abnormality of renal resorption (HP:0011038)	2.40424133
44	Optic disc pallor (HP:0000543)	2.39823668
45	Type II lissencephaly (HP:0007260)	2.39051773
46	Attenuation of retinal blood vessels (HP:0007843)	2.38271420
47	Keratoconus (HP:0000563)	2.37482945
48	Increased corneal curvature (HP:0100692)	2.37482945
49	Asplenia (HP:0001746)	2.37356526
50	Abnormality of the renal cortex (HP:0011035)	2.35493533
51	Azoospermia (HP:0000027)	2.33205395
52	Panhypogammaglobulinemia (HP:0003139)	2.32560163
53	Macrocytic anemia (HP:0001972)	2.32315987
54	Pendular nystagmus (HP:0012043)	2.30477544
55	Concave nail (HP:0001598)	2.21983910
56	Abnormality of macular pigmentation (HP:0008002)	2.21437269
57	Hypoproteinemia (HP:0003075)	2.20403747
58	Abnormality of B cell number (HP:0010975)	2.20165273
59	Lactic acidosis (HP:0003128)	2.19226106
60	Tubular atrophy (HP:0000092)	2.16383645
61	Absent thumb (HP:0009777)	2.15778066
62	3-Methylglutaconic aciduria (HP:0003535)	2.14811179
63	Supernumerary spleens (HP:0009799)	2.13613174
64	Brushfield spots (HP:0001088)	2.11467214
65	Cerebral palsy (HP:0100021)	2.10289406
66	Tetany (HP:0001281)	2.09193529
67	Respiratory failure (HP:0002878)	2.04869521
68	Aplasia/hypoplasia of the uterus (HP:0008684)	2.02830868
69	Abnormality of DNA repair (HP:0003254)	2.01166157
70	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.00918010
71	Respiratory difficulties (HP:0002880)	2.00801505
72	CNS demyelination (HP:0007305)	1.99444383
73	Leukodystrophy (HP:0002415)	1.99070775
74	Lethargy (HP:0001254)	1.98170789
75	Chorioretinal atrophy (HP:0000533)	1.96416153
76	Colon cancer (HP:0003003)	1.93228912
77	Hypothermia (HP:0002045)	1.92301520
78	Adrenal hypoplasia (HP:0000835)	1.91937599
79	Severe muscular hypotonia (HP:0006829)	1.91139238
80	Sclerocornea (HP:0000647)	1.91014241
81	Cerebral hypomyelination (HP:0006808)	1.89665264
82	Pallor (HP:0000980)	1.86611081
83	Abnormality of urine glucose concentration (HP:0011016)	1.86187368
84	Glycosuria (HP:0003076)	1.86187368
85	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.86092820
86	Medial flaring of the eyebrow (HP:0010747)	1.85635330
87	Abnormal drinking behavior (HP:0030082)	1.84820711
88	Polydipsia (HP:0001959)	1.84820711
89	Hypokinesia (HP:0002375)	1.80328744
90	Exercise intolerance (HP:0003546)	1.80163908
91	Abnormal respiratory motile cilium physiology (HP:0012261)	1.79392417
92	Abnormal ciliary motility (HP:0012262)	1.77683177
93	Neoplasm of the adrenal cortex (HP:0100641)	1.77314520
94	Hypoplasia of the ulna (HP:0003022)	1.74654759
95	Bony spicule pigmentary retinopathy (HP:0007737)	1.73487825
96	Chronic sinusitis (HP:0011109)	1.73397706
97	Male pseudohermaphroditism (HP:0000037)	1.71463809
98	Hyperphosphaturia (HP:0003109)	1.71362176
99	Stomatitis (HP:0010280)	1.70932860
100	Postaxial foot polydactyly (HP:0001830)	1.68703018

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	3.72528576
2	WNK4	3.59099330
3	GRK1	2.91862932
4	BCKDK	2.89964805
5	CAMKK2	2.65255811
6	BMPR1B	2.62300729
7	ADRBK2	2.59438993
8	ZAK	2.47656395
9	TLK1	2.42220443
10	BMPR2	2.37527469
11	MAP4K2	2.24312882
12	PINK1	2.10655300
13	STK39	2.03760089
14	TXK	2.03631304
15	VRK2	2.02432547
16	FRK	1.97502372
17	MAP4K1	1.91528060
18	TAOK3	1.90670959
19	KIT	1.81484055
20	MAP3K12	1.76435386
21	NUAK1	1.68988290
22	STK24	1.42889834
23	INSRR	1.36589121
24	BCR	1.30331517
25	FLT3	1.30128194
26	TGFBR1	1.23365115
27	WNK3	1.21553035
28	MAPK13	1.14214859
29	MAP3K11	1.12809967
30	CDK8	1.12049459
31	LMTK2	1.11378007
32	WNK1	1.09489465
33	DAPK2	1.08629030
34	TSSK6	1.07648244
35	PLK4	1.07216821
36	PHKG2	1.03595145
37	PHKG1	1.03595145
38	NME2	1.02951757
39	VRK1	1.01474693
40	PIK3CG	0.97398577
41	NEK1	0.96892153
42	MAPKAPK3	0.95212203
43	PDK2	0.94622440
44	DYRK2	0.92861582
45	ILK	0.91291820
46	PRKCG	0.86068740
47	TNK2	0.83260428
48	CAMKK1	0.82050485
49	PLK3	0.79803666
50	MAP2K7	0.77361111
51	PRKCQ	0.73713470
52	PLK2	0.73660210
53	CSNK1G3	0.73131736
54	CAMK1	0.73084270
55	OXSR1	0.72719343
56	TAF1	0.72304145
57	SCYL2	0.71884053
58	CSF1R	0.68974863
59	ERBB3	0.67337317
60	DAPK1	0.67151408
61	IKBKB	0.67002744
62	SRPK1	0.66937296
63	PRKCH	0.64578027
64	IRAK2	0.63387346
65	MKNK2	0.62964578
66	CSNK1G1	0.58182912
67	MAP2K6	0.55735553
68	MINK1	0.54589419
69	LRRK2	0.53067725
70	CSNK1A1L	0.52385477
71	IRAK4	0.51754010
72	ATR	0.51561666
73	CSNK1G2	0.51408853
74	PAK3	0.50639787
75	TEC	0.50555163
76	TNIK	0.48578890
77	CSNK2A2	0.47539532
78	PIK3CA	0.47041426
79	TESK1	0.46869318
80	ITK	0.45890452
81	PRKACA	0.44792411
82	EPHB2	0.43728045
83	SYK	0.43150494
84	AURKB	0.42311000
85	RIPK4	0.41813884
86	DAPK3	0.40054713
87	CSNK1A1	0.39888715
88	GRK6	0.39120749
89	MYLK	0.37905918
90	TIE1	0.37790363
91	STK11	0.35212656
92	PIM2	0.34492923
93	PTK2B	0.33726804
94	PIM1	0.33430636
95	CAMK2A	0.33137500
96	CDK19	0.33058668
97	PRKCE	0.32759274
98	PRKCA	0.32128315
99	ADRBK1	0.31745016
100	CSNK2A1	0.31472799

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.52086909
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.89492054
3	Ribosome_Homo sapiens_hsa03010	3.62584748
4	Allograft rejection_Homo sapiens_hsa05330	3.26930054
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.14923680
6	Parkinsons disease_Homo sapiens_hsa05012	3.10388353
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.93054848
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.78177604
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.63081854
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.17060801
11	Huntingtons disease_Homo sapiens_hsa05016	2.09177172
12	Homologous recombination_Homo sapiens_hsa03440	2.00548718
13	Alzheimers disease_Homo sapiens_hsa05010	1.99356319
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.97124552
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.95411954
16	Proteasome_Homo sapiens_hsa03050	1.94282764
17	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.77119304
18	One carbon pool by folate_Homo sapiens_hsa00670	1.72015534
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.62713238
20	RNA polymerase_Homo sapiens_hsa03020	1.62009815
21	Butanoate metabolism_Homo sapiens_hsa00650	1.58993750
22	Phototransduction_Homo sapiens_hsa04744	1.45764763
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.42590362
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.41430055
25	Antigen processing and presentation_Homo sapiens_hsa04612	1.34924567
26	Basal transcription factors_Homo sapiens_hsa03022	1.33489248
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.26719946
28	Linoleic acid metabolism_Homo sapiens_hsa00591	1.26548162
29	Rheumatoid arthritis_Homo sapiens_hsa05323	1.25540819
30	Caffeine metabolism_Homo sapiens_hsa00232	1.24496501
31	Nucleotide excision repair_Homo sapiens_hsa03420	1.23448538
32	Sulfur relay system_Homo sapiens_hsa04122	1.19766621
33	Mismatch repair_Homo sapiens_hsa03430	1.05828679
34	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.05464952
35	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.01562549
36	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.99857077
37	RNA degradation_Homo sapiens_hsa03018	0.99837037
38	Base excision repair_Homo sapiens_hsa03410	0.99328945
39	Protein export_Homo sapiens_hsa03060	0.97402909
40	Collecting duct acid secretion_Homo sapiens_hsa04966	0.93265355
41	Fanconi anemia pathway_Homo sapiens_hsa03460	0.92267816
42	Primary immunodeficiency_Homo sapiens_hsa05340	0.89899636
43	Peroxisome_Homo sapiens_hsa04146	0.86337705
44	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.83139209
45	Tryptophan metabolism_Homo sapiens_hsa00380	0.78260588
46	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.77940260
47	Non-homologous end-joining_Homo sapiens_hsa03450	0.77132879
48	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.76577054
49	Purine metabolism_Homo sapiens_hsa00230	0.75567157
50	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.75286952
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.74999450
52	Viral myocarditis_Homo sapiens_hsa05416	0.74918800
53	Pyrimidine metabolism_Homo sapiens_hsa00240	0.74466566
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.72500068
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69135306
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.64525660
57	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.64442682
58	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.63965698
59	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.63299275
60	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.62118918
61	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.60676044
62	Metabolic pathways_Homo sapiens_hsa01100	0.59665389
63	Propanoate metabolism_Homo sapiens_hsa00640	0.59569597
64	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.57460465
65	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.56623164
66	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.56541975
67	Insulin secretion_Homo sapiens_hsa04911	0.55268031
68	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.53402534
69	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.52990176
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.52819406
71	Leishmaniasis_Homo sapiens_hsa05140	0.52216941
72	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.47323260
73	Nicotine addiction_Homo sapiens_hsa05033	0.46600941
74	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.46420694
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45563211
76	Fatty acid degradation_Homo sapiens_hsa00071	0.45056748
77	Sulfur metabolism_Homo sapiens_hsa00920	0.44666313
78	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.41247387
79	Selenocompound metabolism_Homo sapiens_hsa00450	0.41056969
80	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.38478010
81	Fat digestion and absorption_Homo sapiens_hsa04975	0.38324261
82	DNA replication_Homo sapiens_hsa03030	0.37487278
83	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.37263207
84	RNA transport_Homo sapiens_hsa03013	0.36807784
85	Regulation of autophagy_Homo sapiens_hsa04140	0.36518492
86	Morphine addiction_Homo sapiens_hsa05032	0.35110896
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.34985565
88	Pancreatic secretion_Homo sapiens_hsa04972	0.33967626
89	Glutathione metabolism_Homo sapiens_hsa00480	0.33245325
90	Taste transduction_Homo sapiens_hsa04742	0.32206798
91	beta-Alanine metabolism_Homo sapiens_hsa00410	0.31709925
92	Salivary secretion_Homo sapiens_hsa04970	0.31688109
93	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.30201603
94	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.29184919
95	Retinol metabolism_Homo sapiens_hsa00830	0.28723194
96	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.28077947
97	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.28042034
98	Steroid biosynthesis_Homo sapiens_hsa00100	0.25159711
99	Folate biosynthesis_Homo sapiens_hsa00790	0.25002618
100	Bile secretion_Homo sapiens_hsa04976	0.23958902

RPL31P12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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