RPL31P15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)7.24701037
2nonmotile primary cilium assembly (GO:0035058)5.89923880
3ribosomal small subunit biogenesis (GO:0042274)5.48355086
4viral transcription (GO:0019083)5.44744632
5translational termination (GO:0006415)5.25016160
6cotranslational protein targeting to membrane (GO:0006613)4.66395616
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.64825825
8protein neddylation (GO:0045116)4.59839182
9protein targeting to ER (GO:0045047)4.58243218
10substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.55269604
11substrate-independent telencephalic tangential migration (GO:0021826)4.55269604
12negative regulation of mast cell activation (GO:0033004)4.40628307
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.40408718
14behavioral response to nicotine (GO:0035095)4.38501459
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.36677752
16mitochondrial respiratory chain complex I assembly (GO:0032981)4.36677752
17NADH dehydrogenase complex assembly (GO:0010257)4.36677752
18protein localization to endoplasmic reticulum (GO:0070972)4.30561169
19cellular potassium ion homeostasis (GO:0030007)4.30050496
20translational elongation (GO:0006414)4.15669953
21negative regulation of cytosolic calcium ion concentration (GO:0051481)4.12461581
22protein complex biogenesis (GO:0070271)4.10269063
23potassium ion homeostasis (GO:0055075)4.00152518
24regulation of cilium movement (GO:0003352)3.91419529
25body morphogenesis (GO:0010171)3.89647619
26cellular protein complex disassembly (GO:0043624)3.88419294
27positive regulation of growth hormone secretion (GO:0060124)3.87847619
28nucleobase catabolic process (GO:0046113)3.76660363
29viral life cycle (GO:0019058)3.75363655
30negative regulation of response to food (GO:0032096)3.75232396
31negative regulation of appetite (GO:0032099)3.75232396
32ribosomal small subunit assembly (GO:0000028)3.74188043
33embryonic body morphogenesis (GO:0010172)3.72885263
34detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.68453186
35mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.67133476
36somite development (GO:0061053)3.65101197
37myeloid cell homeostasis (GO:0002262)3.64819584
38nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.57560676
39energy coupled proton transport, down electrochemical gradient (GO:0015985)3.55853844
40ATP synthesis coupled proton transport (GO:0015986)3.55853844
41nephron epithelium morphogenesis (GO:0072088)3.54838933
42nephron tubule morphogenesis (GO:0072078)3.54838933
43mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.48236059
44mitochondrial respiratory chain complex assembly (GO:0033108)3.37458356
45cell wall macromolecule catabolic process (GO:0016998)3.37239103
46positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.36979277
47microtubule severing (GO:0051013)3.34446970
48centriole replication (GO:0007099)3.27555582
49protein localization to cilium (GO:0061512)3.24319816
50water-soluble vitamin biosynthetic process (GO:0042364)3.23681348
51renal tubule morphogenesis (GO:0061333)3.22897232
52protein complex disassembly (GO:0043241)3.21317548
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.19556347
54sodium ion export (GO:0071436)3.18569187
55ribosomal large subunit biogenesis (GO:0042273)3.18454788
56detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.18367432
57chaperone-mediated protein transport (GO:0072321)3.14816843
58protein targeting to membrane (GO:0006612)3.11214938
59macromolecular complex disassembly (GO:0032984)3.10002930
60pattern specification involved in kidney development (GO:0061004)3.07295682
61Sertoli cell development (GO:0060009)3.06100487
62cell proliferation in forebrain (GO:0021846)3.05799845
63segment specification (GO:0007379)2.99554143
64pyrimidine nucleobase catabolic process (GO:0006208)2.97344061
65regulation of microtubule-based movement (GO:0060632)2.94894445
66membrane repolarization (GO:0086009)2.92468270
67dentate gyrus development (GO:0021542)2.91714941
68translational initiation (GO:0006413)2.90430820
69behavioral response to ethanol (GO:0048149)2.89626413
70epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.88646730
71regulation of cellular respiration (GO:0043457)2.88024749
72electron transport chain (GO:0022900)2.85793464
73neuron fate determination (GO:0048664)2.85475222
74respiratory electron transport chain (GO:0022904)2.83584645
75cAMP-mediated signaling (GO:0019933)2.81984147
76cell wall macromolecule metabolic process (GO:0044036)2.81422644
77spinal cord association neuron differentiation (GO:0021527)2.79299771
78glycerophospholipid catabolic process (GO:0046475)2.79253041
79platelet dense granule organization (GO:0060155)2.76064102
80striatum development (GO:0021756)2.74701024
81potassium ion import (GO:0010107)2.74367460
82phosphatidylserine acyl-chain remodeling (GO:0036150)2.71129976
83positive regulation of potassium ion transmembrane transport (GO:1901381)2.71068506
84L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.70397398
85regulation of growth hormone secretion (GO:0060123)2.67760742
86brain morphogenesis (GO:0048854)2.67055598
87atrial cardiac muscle cell action potential (GO:0086014)2.65965768
88nuclear-transcribed mRNA catabolic process (GO:0000956)2.63410806
89detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.63252290
90regulation of response to food (GO:0032095)2.61588689
91cellular sodium ion homeostasis (GO:0006883)2.61343391
92cellular response to leptin stimulus (GO:0044320)2.56967051
93regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.56821064
94DNA deamination (GO:0045006)2.56476508
95sodium-independent organic anion transport (GO:0043252)2.54617239
96establishment of protein localization to mitochondrial membrane (GO:0090151)2.50607843
97mRNA catabolic process (GO:0006402)2.50526620
98RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.50038876
99tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.50038876
100parturition (GO:0007567)2.49161054

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.86196701
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.24565601
3RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.67714717
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54259181
5CBX2_27304074_Chip-Seq_ESCs_Mouse2.49312676
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.39630561
7BMI1_23680149_ChIP-Seq_NPCS_Mouse2.31901476
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.24680876
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19252650
10VDR_22108803_ChIP-Seq_LS180_Human2.11190481
11ZNF274_21170338_ChIP-Seq_K562_Hela1.99456634
12REST_21632747_ChIP-Seq_MESCs_Mouse1.96712799
13ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95410021
14GBX2_23144817_ChIP-Seq_PC3_Human1.92071335
15FLI1_27457419_Chip-Seq_LIVER_Mouse1.85520921
16TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79344483
17POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.79344483
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.79207445
19EED_16625203_ChIP-ChIP_MESCs_Mouse1.79037260
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.73127200
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70766068
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68989616
23IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68386891
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68176575
25PCGF2_27294783_Chip-Seq_NPCs_Mouse1.67281801
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58889052
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58889052
28RNF2_27304074_Chip-Seq_NSC_Mouse1.58134199
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55314392
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51043085
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.50855818
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.49703363
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.49344430
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49012390
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47280989
36EWS_26573619_Chip-Seq_HEK293_Human1.46526275
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45812807
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.45728600
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.44271934
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43411699
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.42203138
42P300_19829295_ChIP-Seq_ESCs_Human1.40040354
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.38287292
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35626935
45TP53_22573176_ChIP-Seq_HFKS_Human1.34011276
46IGF1R_20145208_ChIP-Seq_DFB_Human1.28552883
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27221605
48ER_23166858_ChIP-Seq_MCF-7_Human1.26638818
49FUS_26573619_Chip-Seq_HEK293_Human1.23728474
50CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.23138669
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19497283
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18796561
53AR_25329375_ChIP-Seq_VCAP_Human1.18423246
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18318802
55TCF4_22108803_ChIP-Seq_LS180_Human1.18269689
56TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18227448
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.18088692
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18016346
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17892438
60FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17855438
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17440827
62HTT_18923047_ChIP-ChIP_STHdh_Human1.17309566
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16821638
64CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16438709
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15636800
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.15636800
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.14666089
68MTF2_20144788_ChIP-Seq_MESCs_Mouse1.13602867
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12828410
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12528828
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11131309
72SMAD3_21741376_ChIP-Seq_ESCs_Human1.10479994
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10393939
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10321274
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10152059
76RUNX2_22187159_ChIP-Seq_PCA_Human1.09916762
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.09842220
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05951233
79BCAT_22108803_ChIP-Seq_LS180_Human1.05483818
80CBP_20019798_ChIP-Seq_JUKART_Human1.05026517
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05026517
82OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04861114
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03906886
84AR_20517297_ChIP-Seq_VCAP_Human1.02744077
85SMAD4_21799915_ChIP-Seq_A2780_Human1.02536242
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00833670
87PRDM14_20953172_ChIP-Seq_ESCs_Human0.99716422
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98720343
89ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98715469
90NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98705663
91DROSHA_22980978_ChIP-Seq_HELA_Human0.98208580
92TP53_20018659_ChIP-ChIP_R1E_Mouse0.97395372
93FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96549182
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96140139
95STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.95378478
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95262605
97NANOG_20526341_ChIP-Seq_ESCs_Human0.94237410
98GABP_17652178_ChIP-ChIP_JURKAT_Human0.93129739
99STAT3_18555785_Chip-Seq_ESCs_Mouse0.92745071
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92717498

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.88440361
2MP0004142_abnormal_muscle_tone3.29266594
3MP0002138_abnormal_hepatobiliary_system3.25560288
4MP0005423_abnormal_somatic_nervous3.07045034
5MP0002163_abnormal_gland_morphology3.04521228
6MP0005084_abnormal_gallbladder_morpholo3.00229334
7MP0001529_abnormal_vocalization2.97487176
8MP0009379_abnormal_foot_pigmentation2.87374072
9MP0003122_maternal_imprinting2.70543251
10MP0005645_abnormal_hypothalamus_physiol2.51588542
11MP0006292_abnormal_olfactory_placode2.47274291
12MP0003123_paternal_imprinting2.38428010
13MP0003183_abnormal_peptide_metabolism2.31493439
14MP0008789_abnormal_olfactory_epithelium2.30747257
15MP0001968_abnormal_touch/_nociception2.27430189
16MP0002837_dystrophic_cardiac_calcinosis2.27251545
17MP0003646_muscle_fatigue2.14987780
18MP0001984_abnormal_olfaction2.08399336
19MP0002139_abnormal_hepatobiliary_system2.03886686
20MP0005379_endocrine/exocrine_gland_phen1.90757666
21MP0000013_abnormal_adipose_tissue1.89984180
22MP0002653_abnormal_ependyma_morphology1.85910669
23MP0003121_genomic_imprinting1.82480818
24MP0005394_taste/olfaction_phenotype1.77944176
25MP0005499_abnormal_olfactory_system1.77944176
26MP0002734_abnormal_mechanical_nocicepti1.70847729
27MP0001485_abnormal_pinna_reflex1.63981898
28MP0001188_hyperpigmentation1.62510953
29MP0000778_abnormal_nervous_system1.58263943
30MP0009046_muscle_twitch1.54519813
31MP0004885_abnormal_endolymph1.53696216
32MP0008877_abnormal_DNA_methylation1.50587147
33MP0001970_abnormal_pain_threshold1.49553262
34MP0002272_abnormal_nervous_system1.48983011
35MP0001986_abnormal_taste_sensitivity1.45852267
36MP0001486_abnormal_startle_reflex1.44628686
37MP0002102_abnormal_ear_morphology1.43750386
38MP0004742_abnormal_vestibular_system1.42709181
39MP0001440_abnormal_grooming_behavior1.41765213
40MP0002234_abnormal_pharynx_morphology1.39733431
41MP0005551_abnormal_eye_electrophysiolog1.37222069
42MP0002572_abnormal_emotion/affect_behav1.35543644
43MP0009745_abnormal_behavioral_response1.33915676
44MP0002909_abnormal_adrenal_gland1.31830862
45MP0003879_abnormal_hair_cell1.30121485
46MP0006072_abnormal_retinal_apoptosis1.30006318
47MP0003195_calcinosis1.26501310
48MP0001905_abnormal_dopamine_level1.24445672
49MP0003635_abnormal_synaptic_transmissio1.23925664
50MP0002928_abnormal_bile_duct1.23699287
51MP0002733_abnormal_thermal_nociception1.23548844
52MP0002067_abnormal_sensory_capabilities1.22321399
53MP0002064_seizures1.22123372
54MP0002063_abnormal_learning/memory/cond1.19570065
55MP0002557_abnormal_social/conspecific_i1.19028704
56MP0005389_reproductive_system_phenotype1.14769615
57MP0003385_abnormal_body_wall1.14374864
58MP0005670_abnormal_white_adipose1.09775214
59MP0003186_abnormal_redox_activity1.08627247
60MP0000516_abnormal_urinary_system1.08340921
61MP0005367_renal/urinary_system_phenotyp1.08340921
62MP0006276_abnormal_autonomic_nervous1.07815557
63MP0000631_abnormal_neuroendocrine_gland1.05043377
64MP0009780_abnormal_chondrocyte_physiolo1.04358865
65MP0002736_abnormal_nociception_after1.03695041
66MP0003880_abnormal_central_pattern1.03334976
67MP0002160_abnormal_reproductive_system1.02580273
68MP0000955_abnormal_spinal_cord1.01836171
69MP0005248_abnormal_Harderian_gland1.01226534
70MP0003136_yellow_coat_color0.99577133
71MP0004924_abnormal_behavior0.95633884
72MP0005386_behavior/neurological_phenoty0.95633884
73MP0005195_abnormal_posterior_eye0.92756024
74MP0002752_abnormal_somatic_nervous0.91583525
75MP0004147_increased_porphyrin_level0.90276391
76MP0002882_abnormal_neuron_morphology0.84900146
77MP0002735_abnormal_chemical_nociception0.83854105
78MP0000026_abnormal_inner_ear0.83564648
79MP0004145_abnormal_muscle_electrophysio0.82703375
80MP0002233_abnormal_nose_morphology0.81588185
81MP0002184_abnormal_innervation0.78888174
82MP0005253_abnormal_eye_physiology0.78105845
83MP0004043_abnormal_pH_regulation0.77731431
84MP0003567_abnormal_fetal_cardiomyocyte0.75706889
85MP0003938_abnormal_ear_development0.74551734
86MP0002152_abnormal_brain_morphology0.72403021
87MP0003718_maternal_effect0.72112831
88MP0002876_abnormal_thyroid_physiology0.71981287
89MP0000230_abnormal_systemic_arterial0.71904166
90MP0010030_abnormal_orbit_morphology0.71614339
91MP0001286_abnormal_eye_development0.71578069
92MP0004859_abnormal_synaptic_plasticity0.71189904
93MP0000049_abnormal_middle_ear0.70968197
94MP0008872_abnormal_physiological_respon0.70035329
95MP0001270_distended_abdomen0.69505559
96MP0002090_abnormal_vision0.68383957
97MP0001963_abnormal_hearing_physiology0.68223177
98MP0001324_abnormal_eye_pigmentation0.67380191
99MP0005171_absent_coat_pigmentation0.67239372
100MP0000534_abnormal_ureter_morphology0.67072189

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)7.02843439
2Abnormal pancreas size (HP:0012094)4.56541320
3Methylmalonic acidemia (HP:0002912)4.43006426
4Acute necrotizing encephalopathy (HP:0006965)3.94559991
5Abnormality of midbrain morphology (HP:0002418)3.88402101
6Molar tooth sign on MRI (HP:0002419)3.88402101
7Septo-optic dysplasia (HP:0100842)3.76140237
8Hepatocellular necrosis (HP:0001404)3.65454252
9Methylmalonic aciduria (HP:0012120)3.55042343
10Hypoplasia of the uterus (HP:0000013)3.51483711
11Agitation (HP:0000713)3.47802830
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.43288558
13Medial flaring of the eyebrow (HP:0010747)3.37515779
14Abnormal mitochondria in muscle tissue (HP:0008316)3.30213599
15Mitochondrial inheritance (HP:0001427)3.27635562
16Progressive macrocephaly (HP:0004481)3.20504246
17Gait imbalance (HP:0002141)3.19212847
18Acute encephalopathy (HP:0006846)3.17705596
19Abnormal hemoglobin (HP:0011902)3.13106048
20Stenosis of the external auditory canal (HP:0000402)3.12596095
21Nephrogenic diabetes insipidus (HP:0009806)3.04851768
22Hepatic necrosis (HP:0002605)3.03298622
23Abnormality of cells of the erythroid lineage (HP:0012130)3.00312535
24Abnormal rod and cone electroretinograms (HP:0008323)2.98803467
25Congenital primary aphakia (HP:0007707)2.92082941
26Macrocytic anemia (HP:0001972)2.89235135
27Abnormality of vitamin B metabolism (HP:0004340)2.82656180
28Aplasia/hypoplasia of the uterus (HP:0008684)2.79667200
29Exertional dyspnea (HP:0002875)2.78461060
30Myokymia (HP:0002411)2.75496570
31Hemiparesis (HP:0001269)2.64794050
32Abnormality of the vitamin B12 metabolism (HP:0004341)2.64392821
33Absent thumb (HP:0009777)2.60935517
34Increased CSF lactate (HP:0002490)2.58246593
35Increased hepatocellular lipid droplets (HP:0006565)2.57789763
36Type II lissencephaly (HP:0007260)2.57485618
37Hyperventilation (HP:0002883)2.52372891
38Pallor (HP:0000980)2.47557647
39Vaginal atresia (HP:0000148)2.47129223
40Genital tract atresia (HP:0001827)2.47102640
41Focal seizures (HP:0007359)2.46383220
42Abnormality of the labia minora (HP:0012880)2.45730007
43Focal motor seizures (HP:0011153)2.42856171
44Abolished electroretinogram (ERG) (HP:0000550)2.39908554
45Confusion (HP:0001289)2.36461765
46Leukodystrophy (HP:0002415)2.34461622
47Adrenal hypoplasia (HP:0000835)2.34300497
48Pendular nystagmus (HP:0012043)2.33658234
49Hyperglycinemia (HP:0002154)2.33320562
50Neoplasm of the adrenal cortex (HP:0100641)2.30372981
51Lipid accumulation in hepatocytes (HP:0006561)2.29018780
52Optic nerve hypoplasia (HP:0000609)2.28252647
533-Methylglutaconic aciduria (HP:0003535)2.24265363
54Hepatoblastoma (HP:0002884)2.23202760
55Pancreatic cysts (HP:0001737)2.22171627
56Cerebral edema (HP:0002181)2.21847336
57Dialeptic seizures (HP:0011146)2.20525426
58Poor coordination (HP:0002370)2.14514150
59Intestinal atresia (HP:0011100)2.08921800
60Cerebral palsy (HP:0100021)2.06189498
61Absent septum pellucidum (HP:0001331)2.05853845
62Abnormality of vitamin metabolism (HP:0100508)2.05388661
63Polyphagia (HP:0002591)2.01063516
64Neoplasm of the oral cavity (HP:0100649)2.01056539
65Abnormality of urine glucose concentration (HP:0011016)1.98680877
66Glycosuria (HP:0003076)1.98680877
67Rectovaginal fistula (HP:0000143)1.97378514
68Rectal fistula (HP:0100590)1.97378514
69Pancreatic fibrosis (HP:0100732)1.96947792
70Bony spicule pigmentary retinopathy (HP:0007737)1.96927018
71Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96888789
72Vitreoretinal degeneration (HP:0000655)1.93481868
73Bifid tongue (HP:0010297)1.93323225
74Nephronophthisis (HP:0000090)1.91461326
75Abnormality of lateral ventricle (HP:0030047)1.90731720
76Horseshoe kidney (HP:0000085)1.89192905
77Restlessness (HP:0000711)1.89180539
78Status epilepticus (HP:0002133)1.88776219
79Abnormality of homocysteine metabolism (HP:0010919)1.86418878
80Homocystinuria (HP:0002156)1.86418878
81Inability to walk (HP:0002540)1.85712820
82Increased intramyocellular lipid droplets (HP:0012240)1.85552425
83Increased serum lactate (HP:0002151)1.85357323
84Renal Fanconi syndrome (HP:0001994)1.83813083
85Anencephaly (HP:0002323)1.82268558
86Broad-based gait (HP:0002136)1.81342561
87Global brain atrophy (HP:0002283)1.81314641
88True hermaphroditism (HP:0010459)1.79548530
89Congenital stationary night blindness (HP:0007642)1.79130611
90Lissencephaly (HP:0001339)1.78092480
91Cystic liver disease (HP:0006706)1.77838132
92Growth hormone deficiency (HP:0000824)1.75118124
93Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.75100004
94Cerebellar dysplasia (HP:0007033)1.73698785
95Shawl scrotum (HP:0000049)1.72755230
96Degeneration of the lateral corticospinal tracts (HP:0002314)1.72460106
97Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.72460106
98Abnormal hair whorl (HP:0010721)1.71777025
99Abnormality of reticulocytes (HP:0004312)1.69872048
100Abnormal number of erythroid precursors (HP:0012131)1.67897170

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.62088963
2MAP3K43.77562919
3WNK42.99918175
4WNK32.58892265
5TNIK2.52428851
6CCNB12.42804423
7ADRBK22.29084056
8MARK12.16006340
9TRIM282.03906162
10DYRK21.95585994
11GRK11.87855674
12MAPK131.84894780
13KSR11.76601366
14STK161.75726199
15MARK31.66595098
16PINK11.66259837
17MAP3K131.65024974
18NUAK11.62060475
19EPHB21.54531184
20PLK21.52222143
21TYRO31.48294463
22PRKCI1.46007147
23BMPR1B1.45643301
24NTRK21.42141494
25FRK1.42004906
26CAMKK21.40243614
27PIK3CA1.39113467
28EPHA41.38356361
29LRRK21.34693865
30MINK11.33174134
31CDK191.32869943
32CSNK1G11.27476700
33ZAK1.26116758
34CSNK1G31.25961780
35PRKCG1.25864400
36CSNK1G21.22934681
37PLK41.19839742
38NTRK31.13006307
39MAP4K21.07978751
40CDC71.06437006
41PKN11.04760719
42MAP3K61.00599913
43CSNK1A1L0.99689512
44PRKCQ0.96999728
45ADRBK10.95279435
46MAP2K70.93374909
47MAP2K60.91737498
48PRKCZ0.90202961
49STK110.88783859
50ICK0.83333929
51ZAP700.82273492
52PRKCE0.81699134
53CAMK2A0.80556360
54SGK10.79349057
55NLK0.77107818
56EPHA30.74904471
57TIE10.74391646
58INSRR0.73744636
59PRKACA0.69592619
60WNK10.66919373
61PHKG10.66854891
62PHKG20.66854891
63STK390.66553136
64EIF2AK10.65956803
65CAMK10.65657928
66TLK10.65104720
67ILK0.64650899
68CAMKK10.61335755
69CSNK2A20.61200623
70PNCK0.60775297
71MKNK20.59520357
72DAPK30.57915329
73BCKDK0.57860015
74CAMK40.55453943
75PDK20.54749125
76CAMK1D0.54153174
77PAK30.52860239
78DMPK0.52632694
79CSNK1E0.52380065
80DAPK20.52341565
81OXSR10.50107275
82MAP2K40.47217070
83PAK60.46750983
84PIM20.46327779
85CSNK1A10.46198865
86PIM10.44827264
87PRKCA0.44718223
88PLK10.43861624
89PRKDC0.43345763
90CAMK1G0.41696776
91OBSCN0.41609765
92MST40.40304504
93ROCK10.39600768
94MAP3K110.38605579
95MAPK70.37764647
96PRKG10.36291094
97DYRK1B0.35834845
98MAPKAPK50.34297572
99MAPK120.34280168
100ERBB20.34083709

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.29807126
2Oxidative phosphorylation_Homo sapiens_hsa001903.88301259
3Cardiac muscle contraction_Homo sapiens_hsa042603.18389324
4Parkinsons disease_Homo sapiens_hsa050122.95992733
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.81552797
6Protein export_Homo sapiens_hsa030602.78212258
7Alzheimers disease_Homo sapiens_hsa050102.40660943
8Linoleic acid metabolism_Homo sapiens_hsa005912.33888968
9Nicotine addiction_Homo sapiens_hsa050332.30596445
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.23863637
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.22616117
12Asthma_Homo sapiens_hsa053101.94085979
13Huntingtons disease_Homo sapiens_hsa050161.91185845
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.79423472
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.76503668
16Taste transduction_Homo sapiens_hsa047421.59608518
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.50883011
18Fat digestion and absorption_Homo sapiens_hsa049751.37894272
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37490030
20RNA polymerase_Homo sapiens_hsa030201.37314113
21Steroid biosynthesis_Homo sapiens_hsa001001.34816068
22Phototransduction_Homo sapiens_hsa047441.33244520
23RNA degradation_Homo sapiens_hsa030181.31267120
24Sulfur metabolism_Homo sapiens_hsa009201.27208398
25Type I diabetes mellitus_Homo sapiens_hsa049401.22385772
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21655322
27Propanoate metabolism_Homo sapiens_hsa006401.19855816
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18604368
29Insulin secretion_Homo sapiens_hsa049111.17608781
30Dorso-ventral axis formation_Homo sapiens_hsa043201.14615394
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.10372409
32Folate biosynthesis_Homo sapiens_hsa007901.07353657
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06393973
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03223996
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02688494
36Autoimmune thyroid disease_Homo sapiens_hsa053201.01199258
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00714143
38Nitrogen metabolism_Homo sapiens_hsa009101.00481130
39Butanoate metabolism_Homo sapiens_hsa006500.98937899
40Glutamatergic synapse_Homo sapiens_hsa047240.98891297
41Ether lipid metabolism_Homo sapiens_hsa005650.98587066
42beta-Alanine metabolism_Homo sapiens_hsa004100.97874553
43Allograft rejection_Homo sapiens_hsa053300.96540701
44GABAergic synapse_Homo sapiens_hsa047270.95626065
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94371756
46Arachidonic acid metabolism_Homo sapiens_hsa005900.93142562
47Basal cell carcinoma_Homo sapiens_hsa052170.89530136
48Salivary secretion_Homo sapiens_hsa049700.88743399
49Morphine addiction_Homo sapiens_hsa050320.88385452
50Phenylalanine metabolism_Homo sapiens_hsa003600.84528523
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83788614
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83624629
53Chemical carcinogenesis_Homo sapiens_hsa052040.82883685
54Tyrosine metabolism_Homo sapiens_hsa003500.80355761
55Serotonergic synapse_Homo sapiens_hsa047260.77772614
56Graft-versus-host disease_Homo sapiens_hsa053320.77027640
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76240383
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75466198
59Caffeine metabolism_Homo sapiens_hsa002320.74983304
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74537145
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72703885
62Collecting duct acid secretion_Homo sapiens_hsa049660.72033971
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.71752371
64Proteasome_Homo sapiens_hsa030500.70467019
65Olfactory transduction_Homo sapiens_hsa047400.70160192
66One carbon pool by folate_Homo sapiens_hsa006700.70146954
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69968122
68Gastric acid secretion_Homo sapiens_hsa049710.68984353
69Fatty acid elongation_Homo sapiens_hsa000620.68711422
70Vitamin B6 metabolism_Homo sapiens_hsa007500.67127129
71Arginine biosynthesis_Homo sapiens_hsa002200.66933035
72Regulation of autophagy_Homo sapiens_hsa041400.66630110
73Pancreatic secretion_Homo sapiens_hsa049720.65786705
74Glycerolipid metabolism_Homo sapiens_hsa005610.65748120
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65096617
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64271146
77Fatty acid degradation_Homo sapiens_hsa000710.64100031
78Circadian entrainment_Homo sapiens_hsa047130.63816078
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.63586598
80Ovarian steroidogenesis_Homo sapiens_hsa049130.62600821
81Fanconi anemia pathway_Homo sapiens_hsa034600.61770218
82Homologous recombination_Homo sapiens_hsa034400.61594337
83Tryptophan metabolism_Homo sapiens_hsa003800.59412520
84Mineral absorption_Homo sapiens_hsa049780.59141561
85Peroxisome_Homo sapiens_hsa041460.57693011
86Dopaminergic synapse_Homo sapiens_hsa047280.52561462
87Metabolic pathways_Homo sapiens_hsa011000.51671778
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50351322
89Retinol metabolism_Homo sapiens_hsa008300.47419804
90Bile secretion_Homo sapiens_hsa049760.46290228
91Sulfur relay system_Homo sapiens_hsa041220.45705659
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45518461
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43272200
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42446488
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41931422
96Oxytocin signaling pathway_Homo sapiens_hsa049210.37972769
97Notch signaling pathway_Homo sapiens_hsa043300.35924056
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35142691
99Hedgehog signaling pathway_Homo sapiens_hsa043400.34819042
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32394593

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