ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of hypersensitivity (GO:0002883)	6.57389561
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.43345954
3	ATP synthesis coupled proton transport (GO:0015986)	6.22965238
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.22965238
5	viral transcription (GO:0019083)	6.06702237
6	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.89139999
7	translational termination (GO:0006415)	5.85502829
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.68813679
9	positive regulation of mast cell degranulation (GO:0043306)	5.57769893
10	positive regulation of mast cell activation involved in immune response (GO:0033008)	5.57769893
11	cotranslational protein targeting to membrane (GO:0006613)	5.55317615
12	protein targeting to ER (GO:0045047)	5.51218136
13	respiratory electron transport chain (GO:0022904)	5.43315753
14	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	5.40058057
15	protein localization to endoplasmic reticulum (GO:0070972)	5.34650277
16	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.31891466
17	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	5.28402946
18	electron transport chain (GO:0022900)	5.28397609
19	ribosomal small subunit assembly (GO:0000028)	4.93174324
20	positive regulation of mast cell activation (GO:0033005)	4.88429621
21	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	4.84292451
22	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	4.82190820
23	translational elongation (GO:0006414)	4.77945145
24	one-carbon compound transport (GO:0019755)	4.62993815
25	ribosomal large subunit biogenesis (GO:0042273)	4.50720072
26	regulation of cellular respiration (GO:0043457)	4.50075522
27	cellular protein complex disassembly (GO:0043624)	4.30322334
28	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	4.29917021
29	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.24506172
30	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.24506172
31	detection of molecule of bacterial origin (GO:0032490)	4.12059052
32	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.09360453
33	viral life cycle (GO:0019058)	4.07611937
34	neutrophil activation involved in immune response (GO:0002283)	4.00335660
35	positive regulation of myeloid leukocyte mediated immunity (GO:0002888)	3.96642051
36	protein targeting to membrane (GO:0006612)	3.89831721
37	spliceosomal complex assembly (GO:0000245)	3.87926356
38	translational initiation (GO:0006413)	3.85855784
39	interferon-gamma-mediated signaling pathway (GO:0060333)	3.81032411
40	immunoglobulin mediated immune response (GO:0016064)	3.76156342
41	protein complex biogenesis (GO:0070271)	3.72455900
42	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.63808210
43	NADH dehydrogenase complex assembly (GO:0010257)	3.63808210
44	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.63808210
45	regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)	3.60963113
46	T cell costimulation (GO:0031295)	3.55276158
47	lymphocyte costimulation (GO:0031294)	3.51534270
48	translation (GO:0006412)	3.49894609
49	antigen processing and presentation via MHC class Ib (GO:0002475)	3.49369001
50	protein complex disassembly (GO:0043241)	3.44770669
51	hydrogen ion transmembrane transport (GO:1902600)	3.43731574
52	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.42137990
53	mitochondrial respiratory chain complex assembly (GO:0033108)	3.39119612
54	macromolecular complex disassembly (GO:0032984)	3.37511841
55	positive regulation of leukocyte degranulation (GO:0043302)	3.34483391
56	negative regulation of heart rate (GO:0010459)	3.30692797
57	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	3.29892690
58	regulation of mast cell activation (GO:0033003)	3.27135674
59	ATP biosynthetic process (GO:0006754)	3.24984362
60	oxidative phosphorylation (GO:0006119)	3.23536414
61	proton transport (GO:0015992)	3.23069429
62	innate immune response in mucosa (GO:0002227)	3.22448197
63	leukotriene biosynthetic process (GO:0019370)	3.21447555
64	hydrogen transport (GO:0006818)	3.19812196
65	membrane budding (GO:0006900)	3.18126006
66	regulation of inflammatory response to antigenic stimulus (GO:0002861)	3.17488740
67	regulation of T cell tolerance induction (GO:0002664)	3.13967427
68	B cell mediated immunity (GO:0019724)	3.12130779
69	positive regulation of response to biotic stimulus (GO:0002833)	3.10759660
70	regulation of antigen processing and presentation (GO:0002577)	3.08619634
71	nucleotide salvage (GO:0043173)	3.06937292
72	regulation of tolerance induction (GO:0002643)	3.04665005
73	cellular response to interferon-gamma (GO:0071346)	3.01350209
74	regulation of mast cell degranulation (GO:0043304)	2.99213620
75	positive regulation of antigen processing and presentation (GO:0002579)	2.98429045
76	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.97497901
77	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.97281762
78	microglial cell activation (GO:0001774)	2.96333840
79	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.95634057
80	positive regulation of cellular amide metabolic process (GO:0034250)	2.94614197
81	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.94226808
82	detection of external biotic stimulus (GO:0098581)	2.93103434
83	mitochondrial fragmentation involved in apoptotic process (GO:0043653)	2.90147455
84	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.90029002
85	prenylation (GO:0097354)	2.89039843
86	protein prenylation (GO:0018342)	2.89039843
87	monoamine transport (GO:0015844)	2.87417963
88	organ or tissue specific immune response (GO:0002251)	2.84206539
89	regulation of B cell receptor signaling pathway (GO:0050855)	2.83707878
90	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.78628199
91	mast cell activation (GO:0045576)	2.76324216
92	mRNA catabolic process (GO:0006402)	2.75729661
93	establishment of protein localization to membrane (GO:0090150)	2.75267823
94	response to interferon-gamma (GO:0034341)	2.75250568
95	anterograde synaptic vesicle transport (GO:0048490)	2.74956202
96	protein neddylation (GO:0045116)	2.74850323
97	positive regulation of type 2 immune response (GO:0002830)	2.74424368
98	regulation of mast cell activation involved in immune response (GO:0033006)	2.73119418
99	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.64985213
100	myeloid dendritic cell activation (GO:0001773)	2.64428175

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.29885261
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.65325427
3	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.62350792
4	IRF8_21731497_ChIP-ChIP_J774_Mouse	3.09746838
5	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.02847632
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.81872044
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.79505588
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.30970919
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.27488922
10	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.24570938
11	VDR_22108803_ChIP-Seq_LS180_Human	2.23837279
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.13811990
13	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.12099949
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.11236797
15	ELK1_19687146_ChIP-ChIP_HELA_Human	1.97814506
16	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.85112230
17	IGF1R_20145208_ChIP-Seq_DFB_Human	1.82644639
18	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.80150031
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.78814625
20	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.77959752
21	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.77425328
22	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.75621194
23	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.74853684
24	VDR_23849224_ChIP-Seq_CD4+_Human	1.67934451
25	SPI1_23547873_ChIP-Seq_NB4_Human	1.57584470
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.55691250
27	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.54574412
28	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.52690231
29	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.49360865
30	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.48546135
31	FUS_26573619_Chip-Seq_HEK293_Human	1.46852329
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.44855756
33	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.43496953
34	GATA3_26560356_Chip-Seq_TH2_Human	1.41943952
35	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.41217508
36	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.40453921
37	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.39339577
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.38263365
39	NANOG_19829295_ChIP-Seq_ESCs_Human	1.36306220
40	SOX2_19829295_ChIP-Seq_ESCs_Human	1.36306220
41	P300_19829295_ChIP-Seq_ESCs_Human	1.36085550
42	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.34815289
43	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.34250331
44	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.32140751
45	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.31366002
46	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.29115185
47	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.28890569
48	AR_20517297_ChIP-Seq_VCAP_Human	1.28846325
49	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.28346038
50	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.26345780
51	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.25745485
52	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.25745485
53	EWS_26573619_Chip-Seq_HEK293_Human	1.25715329
54	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22366615
55	ER_23166858_ChIP-Seq_MCF-7_Human	1.22091394
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.21389279
57	BCAT_22108803_ChIP-Seq_LS180_Human	1.19997094
58	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.19391430
59	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.18496886
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.18425634
61	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.18348282
62	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.15115010
63	P53_22387025_ChIP-Seq_ESCs_Mouse	1.14126581
64	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.13890531
65	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.13452696
66	TCF4_22108803_ChIP-Seq_LS180_Human	1.13239531
67	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.12969759
68	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.12067747
69	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.10289280
70	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.10215571
71	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.10108970
72	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.09961554
73	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.09647284
74	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.09279739
75	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.09270147
76	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.08827504
77	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.07723339
78	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07403152
79	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.05001099
80	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04867442
81	ZFX_18555785_Chip-Seq_ESCs_Mouse	1.04836140
82	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.04805857
83	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.04490411
84	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.04444106
85	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.04419746
86	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.03978530
87	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.03229835
88	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.02563124
89	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.02530539
90	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.99599126
91	KLF4_18555785_Chip-Seq_ESCs_Mouse	0.98967209
92	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.98435069
93	EZH2_22144423_ChIP-Seq_EOC_Human	0.97972111
94	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.97729607
95	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.97337320
96	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.96166813
97	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.95996022
98	RUNX1_27457419_Chip-Seq_LIVER_Mouse	0.95922059
99	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.95358913
100	CBP_20019798_ChIP-Seq_JUKART_Human	0.95358913

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	5.40121682
2	MP0003806_abnormal_nucleotide_metabolis	4.78888140
3	MP0009379_abnormal_foot_pigmentation	4.67831190
4	MP0005367_renal/urinary_system_phenotyp	3.14354437
5	MP0000516_abnormal_urinary_system	3.14354437
6	MP0005671_abnormal_response_to	3.11896076
7	MP0006082_CNS_inflammation	2.97963692
8	MP0004142_abnormal_muscle_tone	2.94238622
9	MP0001529_abnormal_vocalization	2.89751026
10	MP0003646_muscle_fatigue	2.81618156
11	MP0004145_abnormal_muscle_electrophysio	2.60755890
12	MP0009785_altered_susceptibility_to	2.20543734
13	MP0004147_increased_porphyrin_level	2.01098182
14	MP0003724_increased_susceptibility_to	1.99949709
15	MP0009764_decreased_sensitivity_to	1.98893609
16	MP0005075_abnormal_melanosome_morpholog	1.98681197
17	MP0001800_abnormal_humoral_immune	1.96520892
18	MP0000569_abnormal_digit_pigmentation	1.94588618
19	MP0001905_abnormal_dopamine_level	1.91304821
20	MP0002837_dystrophic_cardiac_calcinosis	1.90578593
21	MP0002148_abnormal_hypersensitivity_rea	1.87298258
22	MP0006036_abnormal_mitochondrial_physio	1.83943255
23	MP0005000_abnormal_immune_tolerance	1.79997780
24	MP0010386_abnormal_urinary_bladder	1.73000002
25	MP0003186_abnormal_redox_activity	1.72406444
26	MP0002452_abnormal_antigen_presenting	1.69553976
27	MP0008875_abnormal_xenobiotic_pharmacok	1.67118648
28	MP0002166_altered_tumor_susceptibility	1.60821988
29	MP0005360_urolithiasis	1.52661026
30	MP0001873_stomach_inflammation	1.50318922
31	MP0001756_abnormal_urination	1.44560009
32	MP0002723_abnormal_immune_serum	1.42723055
33	MP0008872_abnormal_physiological_respon	1.41023833
34	MP0005025_abnormal_response_to	1.38841667
35	MP0002419_abnormal_innate_immunity	1.38517400
36	MP0006072_abnormal_retinal_apoptosis	1.36361228
37	MP0001440_abnormal_grooming_behavior	1.31330262
38	MP0005387_immune_system_phenotype	1.30942761
39	MP0001790_abnormal_immune_system	1.30942761
40	MP0003880_abnormal_central_pattern	1.30154660
41	MP0002090_abnormal_vision	1.25652990
42	MP0000685_abnormal_immune_system	1.22189662
43	MP0001819_abnormal_immune_cell	1.15890926
44	MP0000372_irregular_coat_pigmentation	1.13265881
45	MP0005166_decreased_susceptibility_to	1.12613285
46	MP0003866_abnormal_defecation	1.11486470
47	MP0002420_abnormal_adaptive_immunity	1.11468989
48	MP0002163_abnormal_gland_morphology	1.11341191
49	MP0008469_abnormal_protein_level	1.06715842
50	MP0006035_abnormal_mitochondrial_morpho	1.04974722
51	MP0010155_abnormal_intestine_physiology	1.04839342
52	MP0001845_abnormal_inflammatory_respons	1.04481136
53	MP0003075_altered_response_to	1.02836227
54	MP0005636_abnormal_mineral_homeostasis	1.02656936
55	MP0009046_muscle_twitch	1.02152152
56	MP0002006_tumorigenesis	1.01624813
57	MP0000371_diluted_coat_color	1.01239037
58	MP0005670_abnormal_white_adipose	1.00928424
59	MP0003195_calcinosis	1.00832527
60	MP0006292_abnormal_olfactory_placode	0.96549490
61	MP0005423_abnormal_somatic_nervous	0.93209278
62	MP0001486_abnormal_startle_reflex	0.93191944
63	MP0005551_abnormal_eye_electrophysiolog	0.91497414
64	MP0000538_abnormal_urinary_bladder	0.91286226
65	MP0005165_increased_susceptibility_to	0.91136443
66	MP0005464_abnormal_platelet_physiology	0.90373620
67	MP0001970_abnormal_pain_threshold	0.88090249
68	MP0008873_increased_physiological_sensi	0.84746606
69	MP0004924_abnormal_behavior	0.83932233
70	MP0005386_behavior/neurological_phenoty	0.83932233
71	MP0005408_hypopigmentation	0.82861519
72	MP0005645_abnormal_hypothalamus_physiol	0.82480451
73	MP0002876_abnormal_thyroid_physiology	0.82223052
74	MP0002822_catalepsy	0.81698940
75	MP0005332_abnormal_amino_acid	0.81633810
76	MP0005379_endocrine/exocrine_gland_phen	0.81472492
77	MP0000716_abnormal_immune_system	0.81195109
78	MP0001853_heart_inflammation	0.80647639
79	MP0000858_altered_metastatic_potential	0.80101781
80	MP0005410_abnormal_fertilization	0.77908785
81	MP0001986_abnormal_taste_sensitivity	0.75979910
82	MP0005084_abnormal_gallbladder_morpholo	0.75144249
83	MP0003638_abnormal_response/metabolism_	0.72142432
84	MP0004947_skin_inflammation	0.72033166
85	MP0005174_abnormal_tail_pigmentation	0.71680750
86	MP0002272_abnormal_nervous_system	0.71483813
87	MP0002095_abnormal_skin_pigmentation	0.70378678
88	MP0003137_abnormal_impulse_conducting	0.70040176
89	MP0004215_abnormal_myocardial_fiber	0.69115837
90	MP0009763_increased_sensitivity_to	0.68895649
91	MP0002398_abnormal_bone_marrow	0.67537922
92	MP0003787_abnormal_imprinting	0.65060135
93	MP0009643_abnormal_urine_homeostasis	0.65010619
94	MP0003303_peritoneal_inflammation	0.64288243
95	MP0003045_fibrosis	0.62949335
96	MP0005253_abnormal_eye_physiology	0.62620804
97	MP0005535_abnormal_body_temperature	0.62501063
98	MP0001919_abnormal_reproductive_system	0.62435605
99	MP0005646_abnormal_pituitary_gland	0.62234641
100	MP0009745_abnormal_behavioral_response	0.60940941

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital, generalized hypertrichosis (HP:0004540)	6.68764766
2	Acute necrotizing encephalopathy (HP:0006965)	6.31341080
3	Abnormal mitochondria in muscle tissue (HP:0008316)	5.75382782
4	Hepatocellular necrosis (HP:0001404)	5.42278426
5	Progressive macrocephaly (HP:0004481)	5.41415114
6	3-Methylglutaconic aciduria (HP:0003535)	5.38366888
7	Mitochondrial inheritance (HP:0001427)	5.17696341
8	Acute encephalopathy (HP:0006846)	5.03087473
9	Increased CSF lactate (HP:0002490)	4.53019213
10	Hepatic necrosis (HP:0002605)	4.44253433
11	Exertional dyspnea (HP:0002875)	3.86915072
12	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.78724931
13	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.78724931
14	Cerebral edema (HP:0002181)	3.58371052
15	Woolly hair (HP:0002224)	3.54744443
16	Leukodystrophy (HP:0002415)	3.54291264
17	Fatigue (HP:0012378)	3.40508190
18	Lipid accumulation in hepatocytes (HP:0006561)	3.10289307
19	Increased hepatocellular lipid droplets (HP:0006565)	3.08265414
20	Abnormal hemoglobin (HP:0011902)	3.07976838
21	Renal Fanconi syndrome (HP:0001994)	3.01030294
22	Respiratory failure (HP:0002878)	3.00300541
23	Hypoproteinemia (HP:0003075)	2.93365567
24	Obstructive lung disease (HP:0006536)	2.91049061
25	Chronic obstructive pulmonary disease (HP:0006510)	2.91049061
26	Abnormality of the prostate (HP:0008775)	2.87045584
27	Abolished electroretinogram (ERG) (HP:0000550)	2.84637543
28	Abnormality of alanine metabolism (HP:0010916)	2.75013316
29	Hyperalaninemia (HP:0003348)	2.75013316
30	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.75013316
31	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.70643449
32	Hypothermia (HP:0002045)	2.67082755
33	Optic disc pallor (HP:0000543)	2.61170061
34	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.58709743
35	Split foot (HP:0001839)	2.52655114
36	Lactic acidosis (HP:0003128)	2.41537148
37	Increased intramyocellular lipid droplets (HP:0012240)	2.40750818
38	Hemoptysis (HP:0002105)	2.39022029
39	Elevated erythrocyte sedimentation rate (HP:0003565)	2.36745157
40	CNS demyelination (HP:0007305)	2.35217390
41	Pruritus (HP:0000989)	2.28975712
42	Ureteral obstruction (HP:0006000)	2.26396420
43	Increased serum lactate (HP:0002151)	2.24567169
44	Recurrent gram-negative bacterial infections (HP:0005420)	2.22473915
45	Vasculitis (HP:0002633)	2.22075272
46	Hypoplasia of the pons (HP:0012110)	2.22055921
47	Ureteral stenosis (HP:0000071)	2.21467920
48	IgG deficiency (HP:0004315)	2.21330546
49	Cleft eyelid (HP:0000625)	2.20034323
50	Increased muscle lipid content (HP:0009058)	2.19361612
51	Pallor (HP:0000980)	2.19180118
52	Macrocytic anemia (HP:0001972)	2.18923310
53	Abnormality of secondary sexual hair (HP:0009888)	2.18174235
54	Abnormality of the axillary hair (HP:0100134)	2.18174235
55	Cerebral hemorrhage (HP:0001342)	2.16328753
56	Abnormality of renal resorption (HP:0011038)	2.13454515
57	Basal ganglia calcification (HP:0002135)	2.09793489
58	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.08641923
59	Porencephaly (HP:0002132)	2.08010735
60	Radial bowing (HP:0002986)	2.07697194
61	Rectovaginal fistula (HP:0000143)	1.99035792
62	Rectal fistula (HP:0100590)	1.99035792
63	Pulmonary fibrosis (HP:0002206)	1.98588437
64	Abnormality of the pleura (HP:0002103)	1.97141427
65	Exercise intolerance (HP:0003546)	1.96292584
66	Aplastic anemia (HP:0001915)	1.96218359
67	Congenital stationary night blindness (HP:0007642)	1.93179577
68	X-linked dominant inheritance (HP:0001423)	1.92660404
69	Parakeratosis (HP:0001036)	1.92598113
70	Gliosis (HP:0002171)	1.92053416
71	Abnormality of the pons (HP:0007361)	1.89946686
72	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.89687933
73	Amyloidosis (HP:0011034)	1.85345157
74	Polyneuropathy (HP:0001271)	1.85265212
75	Pulmonary infiltrates (HP:0002113)	1.84339154
76	Recurrent abscess formation (HP:0002722)	1.83591028
77	Meningitis (HP:0001287)	1.82192333
78	Gangrene (HP:0100758)	1.81969004
79	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.80855551
80	Absent/shortened dynein arms (HP:0200106)	1.80855551
81	Amniotic constriction ring (HP:0009775)	1.80471822
82	Abnormality of placental membranes (HP:0011409)	1.80471822
83	Abnormality of serum amino acid levels (HP:0003112)	1.78931371
84	Spastic paraparesis (HP:0002313)	1.78811321
85	Myotonia (HP:0002486)	1.76587023
86	Retinal atrophy (HP:0001105)	1.76134491
87	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.75923919
88	Chest pain (HP:0100749)	1.75768614
89	Type I transferrin isoform profile (HP:0003642)	1.75532243
90	Lethargy (HP:0001254)	1.73843696
91	Median cleft lip (HP:0000161)	1.73207535
92	Abnormality of binocular vision (HP:0011514)	1.71724673
93	Diplopia (HP:0000651)	1.71724673
94	Myokymia (HP:0002411)	1.71079584
95	Acrocyanosis (HP:0001063)	1.69451354
96	Cerebellar dysplasia (HP:0007033)	1.68504717
97	Absent hand (HP:0004050)	1.67836372
98	Respiratory difficulties (HP:0002880)	1.67520774
99	Molar tooth sign on MRI (HP:0002419)	1.66159000
100	Abnormality of midbrain morphology (HP:0002418)	1.66159000

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K12	4.81981293
2	BMPR2	4.58350000
3	MYLK	3.41717367
4	MAP4K2	3.05461764
5	CDK19	2.88734178
6	CSF1R	2.70594636
7	TLK1	2.47931668
8	ILK	2.43915714
9	TXK	2.23716801
10	MAP4K1	2.19851429
11	GRK7	2.19118941
12	SCYL2	2.17397053
13	FLT3	1.81982456
14	KIT	1.80311344
15	PKN1	1.75016299
16	LYN	1.74859786
17	LIMK1	1.53531669
18	PIK3CG	1.52831946
19	TEC	1.51805138
20	DAPK3	1.48099518
21	FES	1.43557644
22	INSRR	1.32246386
23	BLK	1.31119506
24	FRK	1.28877843
25	OXSR1	1.26914248
26	SYK	1.25859625
27	NEK1	1.25835135
28	RPS6KA5	1.25081831
29	IKBKB	1.19451269
30	DAPK1	1.14728967
31	KDR	1.13508069
32	LCK	1.10686790
33	TAOK3	1.10094046
34	EGFR	1.07678617
35	TAOK2	1.04374957
36	BTK	1.04308578
37	GRK1	1.02858999
38	ITK	1.02240333
39	OBSCN	1.00677985
40	ADRBK2	0.99483975
41	RIPK4	0.96399911
42	ACVR1B	0.94539531
43	TESK1	0.89966979
44	EIF2AK3	0.88775056
45	CDK3	0.82757599
46	CSNK1G2	0.82287829
47	JAK3	0.80675415
48	ZAK	0.79630748
49	MARK3	0.79221476
50	ZAP70	0.78544711
51	TRPM7	0.75634698
52	PRKCE	0.75293076
53	IGF1R	0.74514835
54	MATK	0.73102833
55	ADRBK1	0.71746970
56	CSNK1G1	0.71492135
57	EIF2AK1	0.71399974
58	CSNK1G3	0.70347687
59	ERBB3	0.69774551
60	DYRK2	0.68940901
61	MUSK	0.66791444
62	TNK2	0.66761580
63	NUAK1	0.65349970
64	CSNK2A2	0.64570791
65	RPS6KA4	0.64045173
66	ABL1	0.63754931
67	PRKG1	0.62809987
68	TIE1	0.62751597
69	PDK2	0.61085986
70	MAPKAPK5	0.60761957
71	PRKCD	0.60123956
72	WNK3	0.59545005
73	PIM2	0.58798502
74	CSK	0.57961069
75	CSNK2A1	0.56989407
76	ROCK1	0.56898403
77	NME2	0.56316111
78	AURKB	0.56000940
79	EIF2AK2	0.54557266
80	PIM1	0.53210937
81	GRK6	0.51576382
82	HCK	0.50073280
83	CSNK1A1	0.49190912
84	CAMK2A	0.48274409
85	PRKACA	0.47333715
86	MAPK15	0.45144601
87	MINK1	0.44350710
88	PIK3CA	0.44300726
89	PRKCA	0.42416295
90	PDK1	0.41569360
91	CAMK2D	0.41127047
92	CSNK1A1L	0.39706607
93	ABL2	0.38666080
94	PTK2B	0.37548806
95	TYK2	0.36831415
96	MAPK4	0.36295908
97	ERBB2	0.36124760
98	MKNK1	0.35945790
99	MAP3K2	0.35674248
100	ROCK2	0.33731641

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	6.04471661
2	Allograft rejection_Homo sapiens_hsa05330	4.48665371
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	4.35163469
4	Graft-versus-host disease_Homo sapiens_hsa05332	4.29271522
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.74521421
6	Type I diabetes mellitus_Homo sapiens_hsa04940	3.70033907
7	Oxidative phosphorylation_Homo sapiens_hsa00190	3.55354366
8	Ribosome_Homo sapiens_hsa03010	3.33989949
9	Parkinsons disease_Homo sapiens_hsa05012	2.88403938
10	Protein export_Homo sapiens_hsa03060	2.76501672
11	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.72063329
12	Viral myocarditis_Homo sapiens_hsa05416	2.62561801
13	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.33795950
14	Leishmaniasis_Homo sapiens_hsa05140	2.32307748
15	Antigen processing and presentation_Homo sapiens_hsa04612	2.25182783
16	Rheumatoid arthritis_Homo sapiens_hsa05323	2.22119005
17	Alzheimers disease_Homo sapiens_hsa05010	2.14405156
18	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.96297420
19	Huntingtons disease_Homo sapiens_hsa05016	1.87163569
20	Cardiac muscle contraction_Homo sapiens_hsa04260	1.76888216
21	Proteasome_Homo sapiens_hsa03050	1.76058118
22	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.31411101
23	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.14491511
24	Toxoplasmosis_Homo sapiens_hsa05145	1.07702839
25	Phagosome_Homo sapiens_hsa04145	1.00209689
26	RNA polymerase_Homo sapiens_hsa03020	0.99114410
27	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.98974728
28	Tuberculosis_Homo sapiens_hsa05152	0.92561647
29	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.88998747
30	Homologous recombination_Homo sapiens_hsa03440	0.86165872
31	Phototransduction_Homo sapiens_hsa04744	0.83952915
32	Influenza A_Homo sapiens_hsa05164	0.78747633
33	Regulation of autophagy_Homo sapiens_hsa04140	0.75769722
34	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.74755468
35	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.73469963
36	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.63676791
37	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.61156472
38	Sulfur relay system_Homo sapiens_hsa04122	0.54314601
39	Herpes simplex infection_Homo sapiens_hsa05168	0.53944144
40	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.53799104
41	Pertussis_Homo sapiens_hsa05133	0.53304906
42	RNA degradation_Homo sapiens_hsa03018	0.53148030
43	African trypanosomiasis_Homo sapiens_hsa05143	0.49522877
44	Legionellosis_Homo sapiens_hsa05134	0.48439619
45	Mismatch repair_Homo sapiens_hsa03430	0.47150757
46	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.43634636
47	Collecting duct acid secretion_Homo sapiens_hsa04966	0.42031562
48	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.40273890
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.39229549
50	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.39052570
51	Salmonella infection_Homo sapiens_hsa05132	0.37642532
52	Malaria_Homo sapiens_hsa05144	0.37143089
53	Olfactory transduction_Homo sapiens_hsa04740	0.36326061
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.35749967
55	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.34918797
56	Pyrimidine metabolism_Homo sapiens_hsa00240	0.33282027
57	Linoleic acid metabolism_Homo sapiens_hsa00591	0.32654943
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.32355856
59	Nucleotide excision repair_Homo sapiens_hsa03420	0.32291473
60	Tryptophan metabolism_Homo sapiens_hsa00380	0.31673232
61	Primary immunodeficiency_Homo sapiens_hsa05340	0.27339322
62	Tyrosine metabolism_Homo sapiens_hsa00350	0.26844921
63	Nicotine addiction_Homo sapiens_hsa05033	0.26738069
64	Spliceosome_Homo sapiens_hsa03040	0.24944651
65	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.24236622
66	DNA replication_Homo sapiens_hsa03030	0.23121705
67	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.21231012
68	Fanconi anemia pathway_Homo sapiens_hsa03460	0.20723427
69	Salivary secretion_Homo sapiens_hsa04970	0.20280528
70	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.17666171
71	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.17082607
72	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.15161054
73	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.14719536
74	Metabolic pathways_Homo sapiens_hsa01100	0.13839443
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.12936989
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.12502339
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.11798527
78	GABAergic synapse_Homo sapiens_hsa04727	0.11675154
79	Fat digestion and absorption_Homo sapiens_hsa04975	0.11230561
80	Purine metabolism_Homo sapiens_hsa00230	0.10969773
81	Measles_Homo sapiens_hsa05162	0.08664628
82	Sulfur metabolism_Homo sapiens_hsa00920	0.08094260
83	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.07238013
84	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.07203330
85	Caffeine metabolism_Homo sapiens_hsa00232	0.04688381
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.04592399
87	Retinol metabolism_Homo sapiens_hsa00830	0.03777718
88	One carbon pool by folate_Homo sapiens_hsa00670	0.03055173
89	Propanoate metabolism_Homo sapiens_hsa00640	0.02662988
90	Morphine addiction_Homo sapiens_hsa05032	0.02414979
91	Phenylalanine metabolism_Homo sapiens_hsa00360	0.01310261
92	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.00657807
93	Circadian entrainment_Homo sapiens_hsa04713	0.00589828
94	Taste transduction_Homo sapiens_hsa04742	0.00347225
95	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	-0.0262194
96	Peroxisome_Homo sapiens_hsa04146	-0.0134492
97	Histidine metabolism_Homo sapiens_hsa00340	-0.0116573
98	Serotonergic synapse_Homo sapiens_hsa04726	-0.0099184
99	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	-0.0070825
100	Dopaminergic synapse_Homo sapiens_hsa04728	-0.0067618

RPL31P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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