ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.96921593
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.92785180
3	ATP synthesis coupled proton transport (GO:0015986)	5.92785180
4	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.97578798
5	viral transcription (GO:0019083)	4.92933735
6	regulation of hypersensitivity (GO:0002883)	4.85320882
7	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	4.77907905
8	translational termination (GO:0006415)	4.74028163
9	respiratory electron transport chain (GO:0022904)	4.67866863
10	electron transport chain (GO:0022900)	4.62208071
11	ribosomal small subunit assembly (GO:0000028)	4.54293031
12	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.48293674
13	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.33423221
14	protein targeting to ER (GO:0045047)	4.24548836
15	cotranslational protein targeting to membrane (GO:0006613)	4.24085381
16	mast cell activation (GO:0045576)	4.19702144
17	protein localization to endoplasmic reticulum (GO:0070972)	4.07149507
18	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.05866980
19	translational elongation (GO:0006414)	3.99475871
20	positive regulation of mast cell activation involved in immune response (GO:0033008)	3.84574674
21	positive regulation of mast cell degranulation (GO:0043306)	3.84574674
22	DNA deamination (GO:0045006)	3.83855146
23	negative regulation of heart rate (GO:0010459)	3.80454678
24	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.66599762
25	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	3.62194760
26	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.59877709
27	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	3.59387132
28	negative regulation of cell killing (GO:0031342)	3.59387132
29	viral life cycle (GO:0019058)	3.50349459
30	cellular protein complex disassembly (GO:0043624)	3.49748019
31	GPI anchor biosynthetic process (GO:0006506)	3.49480137
32	positive thymic T cell selection (GO:0045059)	3.45168473
33	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.43771553
34	positive regulation of mast cell activation (GO:0033005)	3.40707797
35	maturation of SSU-rRNA (GO:0030490)	3.35293589
36	protein complex biogenesis (GO:0070271)	3.33464895
37	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.27813980
38	ATP biosynthetic process (GO:0006754)	3.27099612
39	immunoglobulin mediated immune response (GO:0016064)	3.26151262
40	GPI anchor metabolic process (GO:0006505)	3.25014968
41	regulation of T cell mediated cytotoxicity (GO:0001914)	3.24133359
42	neutrophil activation involved in immune response (GO:0002283)	3.23694984
43	antigen processing and presentation via MHC class Ib (GO:0002475)	3.22806628
44	hydrogen ion transmembrane transport (GO:1902600)	3.22184952
45	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.17855076
46	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.16765689
47	NADH dehydrogenase complex assembly (GO:0010257)	3.16765689
48	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.16765689
49	regulation of interleukin-8 secretion (GO:2000482)	3.15581826
50	regulation of germinal center formation (GO:0002634)	3.12990293
51	preassembly of GPI anchor in ER membrane (GO:0016254)	3.09272362
52	proton transport (GO:0015992)	3.08034963
53	translational initiation (GO:0006413)	3.07868370
54	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.07865154
55	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.07865154
56	protein neddylation (GO:0045116)	3.06897669
57	hydrogen transport (GO:0006818)	3.03854996
58	negative T cell selection (GO:0043383)	3.03413911
59	mast cell degranulation (GO:0043303)	3.03323491
60	mast cell activation involved in immune response (GO:0002279)	3.03323491
61	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.98412709
62	protein targeting to membrane (GO:0006612)	2.96389761
63	ribosomal large subunit biogenesis (GO:0042273)	2.95743770
64	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.95114354
65	regulation of cellular respiration (GO:0043457)	2.93707863
66	positive T cell selection (GO:0043368)	2.92572191
67	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.91313737
68	respiratory chain complex IV assembly (GO:0008535)	2.90536188
69	platelet dense granule organization (GO:0060155)	2.89807749
70	mitochondrial respiratory chain complex assembly (GO:0033108)	2.88989103
71	mature B cell differentiation (GO:0002335)	2.88246265
72	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.87548103
73	positive regulation of interleukin-17 production (GO:0032740)	2.83526357
74	positive regulation of protein homodimerization activity (GO:0090073)	2.83450215
75	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.83366084
76	translation (GO:0006412)	2.82563341
77	ribosomal small subunit biogenesis (GO:0042274)	2.82027981
78	cytidine metabolic process (GO:0046087)	2.81573018
79	cytidine catabolic process (GO:0006216)	2.81573018
80	cytidine deamination (GO:0009972)	2.81573018
81	cellular response to interleukin-15 (GO:0071350)	2.81227245
82	regulation of regulatory T cell differentiation (GO:0045589)	2.81112860
83	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.80501748
84	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.78816892
85	protein complex disassembly (GO:0043241)	2.78767040
86	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.76365770
87	T cell receptor signaling pathway (GO:0050852)	2.75577320
88	actin nucleation (GO:0045010)	2.71979339
89	T cell costimulation (GO:0031295)	2.71884153
90	regulation of T cell tolerance induction (GO:0002664)	2.70729591
91	gonadal mesoderm development (GO:0007506)	2.70043981
92	negative thymic T cell selection (GO:0045060)	2.69229273
93	mature B cell differentiation involved in immune response (GO:0002313)	2.69105936
94	lymphocyte costimulation (GO:0031294)	2.68995512
95	mannosylation (GO:0097502)	2.67962721
96	regulation of B cell receptor signaling pathway (GO:0050855)	2.66430426
97	kynurenine metabolic process (GO:0070189)	2.66380545
98	regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)	2.66046159
99	macromolecular complex disassembly (GO:0032984)	2.65221849
100	B cell mediated immunity (GO:0019724)	2.64900133

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.49448226
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.65764585
3	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.40469804
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.37590288
5	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.96484037
6	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.78565509
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.78102012
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.67444595
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.48589533
10	VDR_22108803_ChIP-Seq_LS180_Human	2.46353364
11	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.43279409
12	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.33628191
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.25216707
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.24416614
15	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.13220058
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.09449696
17	GATA3_26560356_Chip-Seq_TH2_Human	2.03009659
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.00450537
19	TAF15_26573619_Chip-Seq_HEK293_Human	2.00414778
20	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.95755174
21	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.85695599
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.77996351
23	RUNX_20019798_ChIP-Seq_JUKART_Human	1.77557912
24	MYB_26560356_Chip-Seq_TH2_Human	1.73646317
25	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.58609738
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.58289221
27	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.52443500
28	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.51477970
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.50737588
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.50195419
31	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46501590
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.43649305
33	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.43003221
34	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.43003221
35	ELK1_19687146_ChIP-ChIP_HELA_Human	1.41917296
36	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.41155229
37	AR_20517297_ChIP-Seq_VCAP_Human	1.40497124
38	GATA3_27048872_Chip-Seq_THYMUS_Human	1.39270016
39	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.31985243
40	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31520049
41	TAF2_19829295_ChIP-Seq_ESCs_Human	1.30185473
42	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.28282695
43	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.27252690
44	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.26094173
45	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.25559280
46	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24316970
47	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.22269526
48	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.21546967
49	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21452399
50	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.20990340
51	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.20655368
52	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.20128181
53	BCL6_27268052_Chip-Seq_Bcells_Human	1.20027856
54	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.18756401
55	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.17676722
56	ER_23166858_ChIP-Seq_MCF-7_Human	1.17505505
57	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.15792879
58	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.13986218
59	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.13912993
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12692390
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12692390
62	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.12548913
63	MYC_18940864_ChIP-ChIP_HL60_Human	1.12296030
64	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.11562242
65	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.10666123
66	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10504954
67	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.10123377
68	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.09341557
69	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08811211
70	ERG_20517297_ChIP-Seq_VCAP_Human	1.07647284
71	FUS_26573619_Chip-Seq_HEK293_Human	1.07427729
72	P300_19829295_ChIP-Seq_ESCs_Human	1.04995351
73	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.04552670
74	SPI1_23547873_ChIP-Seq_NB4_Human	1.04087767
75	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.03335724
76	CBP_20019798_ChIP-Seq_JUKART_Human	1.03126829
77	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.03126829
78	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.02569022
79	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.02251014
80	P300_27268052_Chip-Seq_Bcells_Human	1.02039668
81	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.01841830
82	NCOR_22424771_ChIP-Seq_293T_Human	1.01363225
83	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.00850751
84	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.99805185
85	EWS_26573619_Chip-Seq_HEK293_Human	0.98814450
86	STAT1_20625510_ChIP-Seq_HELA_Human	0.98484316
87	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98154566
88	IGF1R_20145208_ChIP-Seq_DFB_Human	0.97927152
89	SPI1_20517297_ChIP-Seq_HL60_Human	0.97878456
90	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.97756107
91	MYB_26560356_Chip-Seq_TH1_Human	0.96632510
92	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.96260011
93	E2F1_20622854_ChIP-Seq_HELA_Human	0.95901119
94	MYC_19829295_ChIP-Seq_ESCs_Human	0.95133637
95	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.93757126
96	BCAT_22108803_ChIP-Seq_LS180_Human	0.93511271
97	GATA3_26560356_Chip-Seq_TH1_Human	0.93126079
98	RBPJ_21746931_ChIP-Seq_IB4_Human	0.92904735
99	NANOG_20526341_ChIP-Seq_ESCs_Human	0.92866302
100	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.91062014

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	4.48291720
2	MP0005671_abnormal_response_to	4.14224962
3	MP0009379_abnormal_foot_pigmentation	3.85710073
4	MP0003724_increased_susceptibility_to	3.12305737
5	MP0006072_abnormal_retinal_apoptosis	2.84857314
6	MP0003646_muscle_fatigue	2.83373664
7	MP0008877_abnormal_DNA_methylation	2.41194940
8	MP0002837_dystrophic_cardiac_calcinosis	2.38565056
9	MP0001800_abnormal_humoral_immune	2.33659281
10	MP0005075_abnormal_melanosome_morpholog	2.26491606
11	MP0002148_abnormal_hypersensitivity_rea	2.19953941
12	MP0005000_abnormal_immune_tolerance	2.18717706
13	MP0000372_irregular_coat_pigmentation	2.16182850
14	MP0009764_decreased_sensitivity_to	2.14795202
15	MP0002166_altered_tumor_susceptibility	2.14168383
16	MP0009785_altered_susceptibility_to	1.97784470
17	MP0004142_abnormal_muscle_tone	1.88466764
18	MP0000685_abnormal_immune_system	1.85538045
19	MP0008872_abnormal_physiological_respon	1.83225796
20	MP0003806_abnormal_nucleotide_metabolis	1.81741651
21	MP0003787_abnormal_imprinting	1.80497190
22	MP0002723_abnormal_immune_serum	1.80061746
23	MP0002452_abnormal_antigen_presenting	1.75371066
24	MP0003763_abnormal_thymus_physiology	1.74767480
25	MP0003436_decreased_susceptibility_to	1.74011193
26	MP0003195_calcinosis	1.73510209
27	MP0003880_abnormal_central_pattern	1.73372674
28	MP0009333_abnormal_splenocyte_physiolog	1.70022613
29	MP0002006_tumorigenesis	1.69453303
30	MP0001819_abnormal_immune_cell	1.65418676
31	MP0006292_abnormal_olfactory_placode	1.64371275
32	MP0002420_abnormal_adaptive_immunity	1.64303967
33	MP0008995_early_reproductive_senescence	1.63218227
34	MP0005646_abnormal_pituitary_gland	1.62733232
35	MP0001919_abnormal_reproductive_system	1.62033728
36	MP0001790_abnormal_immune_system	1.52889485
37	MP0005387_immune_system_phenotype	1.52889485
38	MP0002102_abnormal_ear_morphology	1.51765309
39	MP0005025_abnormal_response_to	1.50308905
40	MP0004145_abnormal_muscle_electrophysio	1.47990635
41	MP0005253_abnormal_eye_physiology	1.47065246
42	MP0008875_abnormal_xenobiotic_pharmacok	1.45857558
43	MP0002876_abnormal_thyroid_physiology	1.40437536
44	MP0001765_abnormal_ion_homeostasis	1.38611181
45	MP0000516_abnormal_urinary_system	1.38524181
46	MP0005367_renal/urinary_system_phenotyp	1.38524181
47	MP0005377_hearing/vestibular/ear_phenot	1.36130220
48	MP0003878_abnormal_ear_physiology	1.36130220
49	MP0005551_abnormal_eye_electrophysiolog	1.33888174
50	MP0001986_abnormal_taste_sensitivity	1.30567823
51	MP0001968_abnormal_touch/_nociception	1.26570005
52	MP0002163_abnormal_gland_morphology	1.25264395
53	MP0005389_reproductive_system_phenotype	1.18700954
54	MP0000716_abnormal_immune_system	1.16389688
55	MP0001501_abnormal_sleep_pattern	1.15521489
56	MP0002419_abnormal_innate_immunity	1.14934425
57	MP0000465_gastrointestinal_hemorrhage	1.13733981
58	MP0001845_abnormal_inflammatory_respons	1.12003583
59	MP0002398_abnormal_bone_marrow	1.09475160
60	MP0003866_abnormal_defecation	1.08209658
61	MP0002736_abnormal_nociception_after	1.07424738
62	MP0001905_abnormal_dopamine_level	1.07372139
63	MP0010155_abnormal_intestine_physiology	1.06428249
64	MP0006082_CNS_inflammation	1.03512456
65	MP0003252_abnormal_bile_duct	1.01698305
66	MP0004885_abnormal_endolymph	0.99695782
67	MP0001873_stomach_inflammation	0.99673931
68	MP0003786_premature_aging	0.99407553
69	MP0002933_joint_inflammation	0.98576250
70	MP0006036_abnormal_mitochondrial_physio	0.97666533
71	MP0005636_abnormal_mineral_homeostasis	0.97371471
72	MP0005410_abnormal_fertilization	0.91629978
73	MP0005360_urolithiasis	0.90495785
74	MP0004147_increased_porphyrin_level	0.89346526
75	MP0005085_abnormal_gallbladder_physiolo	0.88419446
76	MP0001853_heart_inflammation	0.87513208
77	MP0000689_abnormal_spleen_morphology	0.86375059
78	MP0001533_abnormal_skeleton_physiology	0.85723999
79	MP0001970_abnormal_pain_threshold	0.84269153
80	MP0002429_abnormal_blood_cell	0.83451141
81	MP0005645_abnormal_hypothalamus_physiol	0.83213285
82	MP0002405_respiratory_system_inflammati	0.83207330
83	MP0006276_abnormal_autonomic_nervous	0.82604762
84	MP0002234_abnormal_pharynx_morphology	0.81667460
85	MP0002272_abnormal_nervous_system	0.80050806
86	MP0003011_delayed_dark_adaptation	0.79810122
87	MP0002095_abnormal_skin_pigmentation	0.79705008
88	MP0008469_abnormal_protein_level	0.78873261
89	MP0003638_abnormal_response/metabolism_	0.78493221
90	MP0000230_abnormal_systemic_arterial	0.78058143
91	MP0009745_abnormal_behavioral_response	0.78025988
92	MP0002009_preneoplasia	0.77880416
93	MP0005464_abnormal_platelet_physiology	0.77308019
94	MP0009046_muscle_twitch	0.76684116
95	MP0003186_abnormal_redox_activity	0.75501656
96	MP0005332_abnormal_amino_acid	0.73747135
97	MP0005084_abnormal_gallbladder_morpholo	0.71831201
98	MP0005670_abnormal_white_adipose	0.69475968
99	MP0002722_abnormal_immune_system	0.66937587
100	MP0009763_increased_sensitivity_to	0.65785783

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Mitochondrial inheritance (HP:0001427)	4.74841748
2	Acute necrotizing encephalopathy (HP:0006965)	4.56006839
3	IgG deficiency (HP:0004315)	4.53843285
4	Hepatocellular necrosis (HP:0001404)	4.41582513
5	Congenital, generalized hypertrichosis (HP:0004540)	4.32463456
6	Elevated erythrocyte sedimentation rate (HP:0003565)	4.15923532
7	Increased CSF lactate (HP:0002490)	4.12633525
8	Abnormal mitochondria in muscle tissue (HP:0008316)	4.11427348
9	3-Methylglutaconic aciduria (HP:0003535)	4.07140502
10	Progressive macrocephaly (HP:0004481)	3.83104891
11	Acute encephalopathy (HP:0006846)	3.75152274
12	Hepatic necrosis (HP:0002605)	3.73515587
13	Increased hepatocellular lipid droplets (HP:0006565)	3.61867506
14	Lipid accumulation in hepatocytes (HP:0006561)	3.48174943
15	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.26410873
16	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.26410873
17	Increased intramyocellular lipid droplets (HP:0012240)	3.11623938
18	Hypoproteinemia (HP:0003075)	3.07336643
19	Congenital stationary night blindness (HP:0007642)	2.96938986
20	Renal Fanconi syndrome (HP:0001994)	2.95538298
21	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.91149978
22	Stomatitis (HP:0010280)	2.87782233
23	Exertional dyspnea (HP:0002875)	2.87392720
24	Type II lissencephaly (HP:0007260)	2.86509374
25	Severe combined immunodeficiency (HP:0004430)	2.85630638
26	Cerebral edema (HP:0002181)	2.80599461
27	Reticulocytopenia (HP:0001896)	2.72439872
28	Increased muscle lipid content (HP:0009058)	2.71464406
29	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.70285228
30	Optic disc pallor (HP:0000543)	2.67684237
31	Abolished electroretinogram (ERG) (HP:0000550)	2.57368016
32	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.50988602
33	Abnormality of cells of the erythroid lineage (HP:0012130)	2.44834858
34	Abnormal rod and cone electroretinograms (HP:0008323)	2.44298831
35	Macrocytic anemia (HP:0001972)	2.43020530
36	Lactic acidosis (HP:0003128)	2.41493137
37	T lymphocytopenia (HP:0005403)	2.37667761
38	Leukodystrophy (HP:0002415)	2.36232728
39	Increased serum lactate (HP:0002151)	2.32666959
40	Attenuation of retinal blood vessels (HP:0007843)	2.30970552
41	Abnormality of the prostate (HP:0008775)	2.30691078
42	Hypothermia (HP:0002045)	2.30511067
43	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.28905367
44	Abnormality of midbrain morphology (HP:0002418)	2.26429887
45	Molar tooth sign on MRI (HP:0002419)	2.26429887
46	Respiratory failure (HP:0002878)	2.24305890
47	Large eyes (HP:0001090)	2.22815302
48	Abnormality of alanine metabolism (HP:0010916)	2.22702296
49	Hyperalaninemia (HP:0003348)	2.22702296
50	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.22702296
51	Abnormality of renal resorption (HP:0011038)	2.18615764
52	Decreased central vision (HP:0007663)	2.17057430
53	Abnormality of T cells (HP:0002843)	2.12998211
54	Aplastic anemia (HP:0001915)	2.11575302
55	Chronic diarrhea (HP:0002028)	2.11475719
56	Abnormality of T cell number (HP:0011839)	2.10407671
57	Panhypogammaglobulinemia (HP:0003139)	2.09804637
58	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.09765231
59	Alveolar cell carcinoma (HP:0006519)	2.09432803
60	Thyroiditis (HP:0100646)	2.06431624
61	Parakeratosis (HP:0001036)	2.05771628
62	Absent/shortened dynein arms (HP:0200106)	2.04351368
63	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.04351368
64	Combined immunodeficiency (HP:0005387)	2.02744974
65	Pancreatic cysts (HP:0001737)	2.01923485
66	Porencephaly (HP:0002132)	2.01157655
67	Pallor (HP:0000980)	1.98632247
68	Cerebral palsy (HP:0100021)	1.96199414
69	Pulmonary infiltrates (HP:0002113)	1.93367587
70	Spastic paraparesis (HP:0002313)	1.93166031
71	Abnormality of urine glucose concentration (HP:0011016)	1.93127522
72	Glycosuria (HP:0003076)	1.93127522
73	Abnormal number of erythroid precursors (HP:0012131)	1.90314081
74	Radial bowing (HP:0002986)	1.90140104
75	Woolly hair (HP:0002224)	1.88838757
76	Hyperphosphaturia (HP:0003109)	1.87724418
77	Erythroderma (HP:0001019)	1.87322874
78	Adactyly (HP:0009776)	1.86963746
79	Microretrognathia (HP:0000308)	1.85088767
80	Methylmalonic acidemia (HP:0002912)	1.84222087
81	Abnormal hemoglobin (HP:0011902)	1.82310271
82	Absent thumb (HP:0009777)	1.79884725
83	Myositis (HP:0100614)	1.79802741
84	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.78352348
85	B lymphocytopenia (HP:0010976)	1.77762424
86	Chronic mucocutaneous candidiasis (HP:0002728)	1.76580085
87	Recurrent cutaneous fungal infections (HP:0011370)	1.76580085
88	Lethargy (HP:0001254)	1.75840411
89	Azoospermia (HP:0000027)	1.75419664
90	Congenital ichthyosiform erythroderma (HP:0007431)	1.73720946
91	Neoplasm of the tracheobronchial system (HP:0100552)	1.73401407
92	Abnormality of B cell number (HP:0010975)	1.72404201
93	Testicular atrophy (HP:0000029)	1.70674505
94	Exercise intolerance (HP:0003546)	1.67710274
95	Abnormality of eosinophils (HP:0001879)	1.67479120
96	Pruritus (HP:0000989)	1.67426819
97	Abnormality of DNA repair (HP:0003254)	1.67402096
98	Pustule (HP:0200039)	1.66377809
99	Recurrent bronchitis (HP:0002837)	1.64599136
100	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.63834051

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BMPR2	3.84684905
2	CDK19	3.82623090
3	MAP3K12	3.66886619
4	TLK1	3.66729638
5	TXK	3.58510257
6	TAOK3	3.13858321
7	ZAK	2.89408283
8	MAP4K1	2.81320933
9	MAP4K2	2.44449900
10	MYLK	2.36678297
11	NUAK1	2.18819229
12	GRK6	2.11603189
13	SCYL2	2.01770931
14	KDR	1.92722638
15	GRK1	1.86238853
16	ADRBK2	1.83486935
17	CSF1R	1.77432175
18	TNK2	1.73014661
19	TESK2	1.67318868
20	TEC	1.55453094
21	ERBB3	1.49699997
22	ITK	1.46738225
23	FES	1.42134552
24	ILK	1.37340656
25	IKBKB	1.37140167
26	PINK1	1.37107145
27	SYK	1.36069039
28	OXSR1	1.35942627
29	BCKDK	1.34618543
30	LYN	1.26094300
31	MAP2K2	1.20914031
32	BTK	1.20769151
33	CDK8	1.19882973
34	FRK	1.19713063
35	ZAP70	1.13181241
36	STK16	1.11081129
37	TRPM7	1.10841784
38	LIMK1	1.10738764
39	KIT	1.07437705
40	WNK4	1.03858258
41	DAPK1	1.01231577
42	INSRR	0.99668008
43	MUSK	0.99651875
44	DAPK3	0.95638603
45	PIK3CG	0.95270368
46	PIM1	0.93139758
47	LCK	0.89241982
48	RIPK4	0.87837462
49	FLT3	0.76367403
50	PHKG2	0.74248684
51	PHKG1	0.74248684
52	CAMKK2	0.73301989
53	ROCK1	0.71394075
54	DAPK2	0.70653130
55	OBSCN	0.69065423
56	MAP3K4	0.68897009
57	NME1	0.67508370
58	PRKCQ	0.67462887
59	TIE1	0.66790171
60	IGF1R	0.63189977
61	PLK4	0.62799233
62	RPS6KA5	0.62226708
63	CDK3	0.61698830
64	ABL1	0.60533950
65	GRK7	0.58883336
66	PIK3CA	0.56711830
67	TESK1	0.55740180
68	CSNK1G2	0.54452753
69	IKBKE	0.54413081
70	PIM2	0.54105028
71	ACVR1B	0.53635498
72	HCK	0.52912578
73	RPS6KA4	0.52194891
74	MATK	0.51335326
75	JAK3	0.50337191
76	CSNK1G3	0.50151878
77	VRK2	0.50004309
78	VRK1	0.44501137
79	ARAF	0.42439671
80	PRKACA	0.42351621
81	PRKG1	0.41659361
82	PRKCA	0.40187830
83	CSK	0.39985828
84	MAPK13	0.37784489
85	ERBB2	0.37309801
86	ADRBK1	0.37210323
87	AURKB	0.37158349
88	EGFR	0.36612147
89	PTK2B	0.36570759
90	PRKCE	0.36387494
91	WNK3	0.34001240
92	STK39	0.32087489
93	MAP2K6	0.31308632
94	PAK4	0.30586486
95	MARK3	0.29443427
96	MAP3K14	0.28129837
97	CSNK2A2	0.27170780
98	CSNK2A1	0.27127018
99	CAMK2A	0.27035986
100	INSR	0.26967521

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.71197010
2	Allograft rejection_Homo sapiens_hsa05330	3.86920738
3	Graft-versus-host disease_Homo sapiens_hsa05332	3.85990355
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.80011261
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.73591847
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.55877119
7	Ribosome_Homo sapiens_hsa03010	3.51667664
8	Type I diabetes mellitus_Homo sapiens_hsa04940	3.17990213
9	Parkinsons disease_Homo sapiens_hsa05012	3.05458684
10	Proteasome_Homo sapiens_hsa03050	2.33564186
11	Primary immunodeficiency_Homo sapiens_hsa05340	2.26434496
12	Alzheimers disease_Homo sapiens_hsa05010	2.22412680
13	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.16533900
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.12676071
15	Antigen processing and presentation_Homo sapiens_hsa04612	2.12668372
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.02926909
17	Protein export_Homo sapiens_hsa03060	1.96240167
18	Viral myocarditis_Homo sapiens_hsa05416	1.88096841
19	Huntingtons disease_Homo sapiens_hsa05016	1.86903414
20	Cardiac muscle contraction_Homo sapiens_hsa04260	1.79433295
21	Rheumatoid arthritis_Homo sapiens_hsa05323	1.74978649
22	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.62388641
23	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.35978049
24	Leishmaniasis_Homo sapiens_hsa05140	1.33042687
25	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.31369086
26	Homologous recombination_Homo sapiens_hsa03440	1.29409728
27	RNA polymerase_Homo sapiens_hsa03020	1.21862133
28	Phototransduction_Homo sapiens_hsa04744	1.21192212
29	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.19088473
30	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.11841887
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.05420653
32	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.03653075
33	Nitrogen metabolism_Homo sapiens_hsa00910	0.99235821
34	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.97880437
35	Linoleic acid metabolism_Homo sapiens_hsa00591	0.94755260
36	RNA degradation_Homo sapiens_hsa03018	0.92230882
37	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.88536106
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.80628481
39	Tryptophan metabolism_Homo sapiens_hsa00380	0.79167560
40	Caffeine metabolism_Homo sapiens_hsa00232	0.79046138
41	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.77477088
42	Olfactory transduction_Homo sapiens_hsa04740	0.73529844
43	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.71450583
44	One carbon pool by folate_Homo sapiens_hsa00670	0.61960785
45	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.60351960
46	Chemical carcinogenesis_Homo sapiens_hsa05204	0.59881341
47	Collecting duct acid secretion_Homo sapiens_hsa04966	0.58565262
48	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.54653676
49	Tuberculosis_Homo sapiens_hsa05152	0.54615696
50	Toxoplasmosis_Homo sapiens_hsa05145	0.53752461
51	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.52814353
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.49567435
53	Fanconi anemia pathway_Homo sapiens_hsa03460	0.48091351
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.47347052
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46994697
56	Nicotine addiction_Homo sapiens_hsa05033	0.45666246
57	Nucleotide excision repair_Homo sapiens_hsa03420	0.45033769
58	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.44530159
59	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.43549249
60	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.43225981
61	Sulfur metabolism_Homo sapiens_hsa00920	0.43062936
62	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.41603288
63	Herpes simplex infection_Homo sapiens_hsa05168	0.41576471
64	Phagosome_Homo sapiens_hsa04145	0.40318525
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.38526283
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.37447280
67	Pyrimidine metabolism_Homo sapiens_hsa00240	0.36966596
68	Morphine addiction_Homo sapiens_hsa05032	0.35680783
69	Sulfur relay system_Homo sapiens_hsa04122	0.33842669
70	Spliceosome_Homo sapiens_hsa03040	0.33466866
71	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.33029899
72	Retinol metabolism_Homo sapiens_hsa00830	0.32916066
73	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.32559920
74	Tyrosine metabolism_Homo sapiens_hsa00350	0.31986033
75	Phenylalanine metabolism_Homo sapiens_hsa00360	0.31561460
76	Basal transcription factors_Homo sapiens_hsa03022	0.31509529
77	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.30110764
78	Taste transduction_Homo sapiens_hsa04742	0.29937595
79	Pertussis_Homo sapiens_hsa05133	0.29693092
80	Peroxisome_Homo sapiens_hsa04146	0.29610778
81	Metabolic pathways_Homo sapiens_hsa01100	0.28398803
82	Regulation of autophagy_Homo sapiens_hsa04140	0.27649083
83	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.27543501
84	Purine metabolism_Homo sapiens_hsa00230	0.26902455
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.26055002
86	Mismatch repair_Homo sapiens_hsa03430	0.25732992
87	Butanoate metabolism_Homo sapiens_hsa00650	0.24558490
88	Ether lipid metabolism_Homo sapiens_hsa00565	0.23828607
89	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.21612999
90	Malaria_Homo sapiens_hsa05144	0.20900030
91	Propanoate metabolism_Homo sapiens_hsa00640	0.20825703
92	Salivary secretion_Homo sapiens_hsa04970	0.20025833
93	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.17986607
94	African trypanosomiasis_Homo sapiens_hsa05143	0.17509384
95	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.17447397
96	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.17111483
97	Measles_Homo sapiens_hsa05162	0.17013013
98	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.15477604
99	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.15315514
100	Influenza A_Homo sapiens_hsa05164	0.13138136

RPL31P28

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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