RPL31P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)8.47361255
2viral transcription (GO:0019083)7.84734516
3leukocyte aggregation (GO:0070486)7.82312083
4translational termination (GO:0006415)7.43853289
5ribosomal small subunit assembly (GO:0000028)6.72647399
6ribosomal small subunit biogenesis (GO:0042274)6.65985630
7positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)6.60215431
8glycoprotein catabolic process (GO:0006516)6.45200620
9chaperone-mediated protein transport (GO:0072321)6.28186238
10translational elongation (GO:0006414)6.25124487
11protein targeting to ER (GO:0045047)5.96190970
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.94924287
13cotranslational protein targeting to membrane (GO:0006613)5.87670648
14rRNA transcription (GO:0009303)5.76910870
15establishment of protein localization to endoplasmic reticulum (GO:0072599)5.67333134
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.63519141
17viral life cycle (GO:0019058)5.63058660
18protein localization to endoplasmic reticulum (GO:0070972)5.58773588
19cellular protein complex disassembly (GO:0043624)5.57709089
20positive regulation of signal transduction by p53 class mediator (GO:1901798)5.20474136
21protein complex disassembly (GO:0043241)4.65612334
22myoblast migration (GO:0051451)4.64309472
23positive regulation of defense response to virus by host (GO:0002230)4.62338025
24macromolecular complex disassembly (GO:0032984)4.51422080
25positive regulation of vascular permeability (GO:0043117)4.49277672
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.49265725
27translational initiation (GO:0006413)4.43057382
28myelin assembly (GO:0032288)4.18882175
29induction of positive chemotaxis (GO:0050930)4.15053233
30protein targeting to membrane (GO:0006612)4.08232231
31resolution of meiotic recombination intermediates (GO:0000712)3.95172358
32nonmotile primary cilium assembly (GO:0035058)3.83727935
33DNA deamination (GO:0045006)3.82241223
34pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.78090184
35macroautophagy (GO:0016236)3.75313897
36meiotic chromosome segregation (GO:0045132)3.70462707
37forebrain morphogenesis (GO:0048853)3.66269575
38SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)3.65859313
39spinal cord development (GO:0021510)3.64385914
40nuclear-transcribed mRNA catabolic process (GO:0000956)3.62597615
41motile cilium assembly (GO:0044458)3.53800437
42reciprocal DNA recombination (GO:0035825)3.51528763
43reciprocal meiotic recombination (GO:0007131)3.51528763
44mRNA catabolic process (GO:0006402)3.43897033
45nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)3.42013447
46ATP synthesis coupled proton transport (GO:0015986)3.41620592
47energy coupled proton transport, down electrochemical gradient (GO:0015985)3.41620592
48ribosomal large subunit biogenesis (GO:0042273)3.40308841
49hair cell differentiation (GO:0035315)3.34015373
50UV protection (GO:0009650)3.33838474
51hematopoietic stem cell differentiation (GO:0060218)3.26797335
52epithelial cilium movement (GO:0003351)3.26191403
53organelle disassembly (GO:1903008)3.18988067
54protein neddylation (GO:0045116)3.16502469
55astrocyte differentiation (GO:0048708)3.15100655
56lateral ventricle development (GO:0021670)3.11632050
57erythrocyte maturation (GO:0043249)3.10641617
58positive regulation of monocyte chemotaxis (GO:0090026)3.08613502
59pyrimidine nucleotide catabolic process (GO:0006244)3.07621779
60mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.05894682
61translation (GO:0006412)3.02562130
62negative regulation of macroautophagy (GO:0016242)2.99193471
63I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.98080577
64RNA catabolic process (GO:0006401)2.96545321
65substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.95150502
66substrate-independent telencephalic tangential migration (GO:0021826)2.95150502
67cell proliferation in forebrain (GO:0021846)2.95101758
68negative regulation of granulocyte differentiation (GO:0030853)2.92055313
69positive regulation of protein homooligomerization (GO:0032464)2.89079192
70sulfate transmembrane transport (GO:1902358)2.89017433
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.87182293
72mitochondrial respiratory chain complex I assembly (GO:0032981)2.87182293
73NADH dehydrogenase complex assembly (GO:0010257)2.87182293
74mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.86700852
75iron-sulfur cluster assembly (GO:0016226)2.84105935
76metallo-sulfur cluster assembly (GO:0031163)2.84105935
77behavioral response to nicotine (GO:0035095)2.83286666
78positive regulation of T cell apoptotic process (GO:0070234)2.82611192
79ubiquinone biosynthetic process (GO:0006744)2.79886105
80protein complex biogenesis (GO:0070271)2.70798141
81establishment of protein localization to membrane (GO:0090150)2.68900296
82ncRNA 3-end processing (GO:0043628)2.68091718
83regulation of action potential (GO:0098900)2.66003707
84ribonucleoprotein complex disassembly (GO:0032988)2.65529760
85positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.63694015
86somite development (GO:0061053)2.62601346
87negative regulation of mast cell activation (GO:0033004)2.62396535
88cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.60926516
89regulation of glycogen (starch) synthase activity (GO:2000465)2.60361194
90RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.59335067
91tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.59335067
92cilium movement (GO:0003341)2.59303830
93regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)2.58936000
94regulation of cilium movement (GO:0003352)2.58281343
95respiratory electron transport chain (GO:0022904)2.56232150
96protein targeting (GO:0006605)2.55646517
97electron transport chain (GO:0022900)2.55108136
98dendritic spine morphogenesis (GO:0060997)2.54910730
99negative regulation of organelle assembly (GO:1902116)2.53741142
100activation of MAPKKK activity (GO:0000185)10.4244968

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.16865725
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.82791079
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.22864760
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.13535312
5CBX2_27304074_Chip-Seq_ESCs_Mouse2.63334833
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.33008744
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.32910389
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.25702632
9RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.25627388
10SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21794576
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.15906114
12EZH2_27294783_Chip-Seq_ESCs_Mouse2.11853705
13CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.99296409
14JARID2_20075857_ChIP-Seq_MESCs_Mouse1.85661464
15STAT1_20625510_ChIP-Seq_HELA_Human1.82240320
16GABP_17652178_ChIP-ChIP_JURKAT_Human1.77285386
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73219065
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.72277731
19RNF2_27304074_Chip-Seq_ESCs_Mouse1.71925806
20VDR_22108803_ChIP-Seq_LS180_Human1.71896036
21YY1_21170310_ChIP-Seq_MESCs_Mouse1.62288216
22EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59127913
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59127913
24ELF1_20517297_ChIP-Seq_JURKAT_Human1.54739334
25CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.54137563
26REST_21632747_ChIP-Seq_MESCs_Mouse1.51563108
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49918059
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.49499427
29TP53_22573176_ChIP-Seq_HFKS_Human1.47908371
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47064679
31CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.45866053
32GBX2_23144817_ChIP-Seq_PC3_Human1.42774996
33ERA_21632823_ChIP-Seq_H3396_Human1.39660865
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.37149844
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36735694
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36487735
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35167279
38RNF2_27304074_Chip-Seq_NSC_Mouse1.34151353
39AR_20517297_ChIP-Seq_VCAP_Human1.33442015
40GATA3_21878914_ChIP-Seq_MCF-7_Human1.32830883
41DROSHA_22980978_ChIP-Seq_HELA_Human1.32380437
42GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31481313
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.31443791
44TAF2_19829295_ChIP-Seq_ESCs_Human1.29005540
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.28933486
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.28493327
47P53_22127205_ChIP-Seq_FIBROBLAST_Human1.26036647
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25895543
49VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.24401937
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23803052
51CTCF_27219007_Chip-Seq_Bcells_Human1.22659264
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21337670
53NANOG_20526341_ChIP-Seq_ESCs_Human1.20889627
54CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.19342665
55E2F1_20622854_ChIP-Seq_HELA_Human1.19053329
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18488151
57TP53_20018659_ChIP-ChIP_R1E_Mouse1.18277431
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.14678625
59CTCF_20526341_ChIP-Seq_ESCs_Human1.14567538
60RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.14480227
61NCOR_22424771_ChIP-Seq_293T_Human1.13307745
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13017612
63EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.11972785
64IGF1R_20145208_ChIP-Seq_DFB_Human1.11709013
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.11604532
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09859525
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09435476
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05727716
69YY1_22570637_ChIP-Seq_MALME-3M_Human1.04302149
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04045771
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03922218
72SA1_27219007_Chip-Seq_Bcells_Human1.03810046
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03170305
74FOXP1_21924763_ChIP-Seq_HESCs_Human1.02242456
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.02088778
76FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02083052
77P68_20966046_ChIP-Seq_HELA_Human1.01705252
78CIITA_25753668_ChIP-Seq_RAJI_Human1.01394204
79OCT4_19829295_ChIP-Seq_ESCs_Human0.98271228
80XRN2_22483619_ChIP-Seq_HELA_Human0.98206552
81FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98171976
82FOXA1_25329375_ChIP-Seq_VCAP_Human0.98171976
83BCL6_27268052_Chip-Seq_Bcells_Human0.97910884
84KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97766417
85SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96583862
86GATA1_26923725_Chip-Seq_HPCs_Mouse0.95612075
87MYC_19829295_ChIP-Seq_ESCs_Human0.95387476
88ZNF274_21170338_ChIP-Seq_K562_Hela0.95081347
89MYC_18940864_ChIP-ChIP_HL60_Human0.94798487
90SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93641484
91TTF2_22483619_ChIP-Seq_HELA_Human0.92693896
92DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92356306
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92202309
94P53_21459846_ChIP-Seq_SAOS-2_Human0.91471040
95TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91370014
96RAC3_21632823_ChIP-Seq_H3396_Human0.89409718
97RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89010747
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87306654
99ETV2_25802403_ChIP-Seq_MESCs_Mouse0.86743851
100FUS_26573619_Chip-Seq_HEK293_Human0.86441965

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005623_abnormal_meninges_morphology7.36223989
2MP0009379_abnormal_foot_pigmentation5.91705293
3MP0000750_abnormal_muscle_regeneration3.68863786
4MP0003787_abnormal_imprinting3.15524771
5MP0009384_cardiac_valve_regurgitation3.06904235
6MP0002638_abnormal_pupillary_reflex2.89270064
7MP0006292_abnormal_olfactory_placode2.69224782
8MP0002938_white_spotting2.64523767
9MP0003786_premature_aging2.44220863
10MP0003121_genomic_imprinting2.19424570
11MP0004142_abnormal_muscle_tone2.15853826
12MP0000013_abnormal_adipose_tissue2.12834209
13MP0003122_maternal_imprinting2.05388325
14MP0002163_abnormal_gland_morphology2.03381514
15MP0003123_paternal_imprinting2.02205061
16MP0005551_abnormal_eye_electrophysiolog1.90966586
17MP0000762_abnormal_tongue_morphology1.90394672
18MP0005423_abnormal_somatic_nervous1.75186614
19MP0004130_abnormal_muscle_cell1.58709389
20MP0005645_abnormal_hypothalamus_physiol1.57767060
21MP0003646_muscle_fatigue1.54988330
22MP0006276_abnormal_autonomic_nervous1.48951037
23MP0000631_abnormal_neuroendocrine_gland1.46543841
24MP0009764_decreased_sensitivity_to1.39279482
25MP0002067_abnormal_sensory_capabilities1.33022014
26MP0004147_increased_porphyrin_level1.29657485
27MP0002234_abnormal_pharynx_morphology1.29025671
28MP0001905_abnormal_dopamine_level1.28725130
29MP0005671_abnormal_response_to1.28617831
30MP0000778_abnormal_nervous_system1.27772129
31MP0001485_abnormal_pinna_reflex1.23606204
32MP0004742_abnormal_vestibular_system1.23389428
33MP0000858_altered_metastatic_potential1.23336428
34MP0005379_endocrine/exocrine_gland_phen1.23124405
35MP0000049_abnormal_middle_ear1.22406409
36MP0002733_abnormal_thermal_nociception1.20678738
37MP0002063_abnormal_learning/memory/cond1.19449596
38MP0002572_abnormal_emotion/affect_behav1.16368695
39MP0002653_abnormal_ependyma_morphology1.15943292
40MP0005195_abnormal_posterior_eye1.14685134
41MP0008789_abnormal_olfactory_epithelium1.13193986
42MP0001970_abnormal_pain_threshold1.12908241
43MP0003011_delayed_dark_adaptation1.11998109
44MP0003385_abnormal_body_wall1.11381307
45MP0002160_abnormal_reproductive_system1.11052647
46MP0003136_yellow_coat_color1.08261128
47MP0001293_anophthalmia1.06341479
48MP0002272_abnormal_nervous_system1.05276808
49MP0004947_skin_inflammation1.04837118
50MP0008877_abnormal_DNA_methylation1.04535914
51MP0002177_abnormal_outer_ear1.04420414
52MP0004885_abnormal_endolymph1.02584174
53MP0009046_muscle_twitch1.01368504
54MP0001968_abnormal_touch/_nociception1.01155917
55MP0008775_abnormal_heart_ventricle1.00268016
56MP0009745_abnormal_behavioral_response0.99521046
57MP0005389_reproductive_system_phenotype0.96934059
58MP0002249_abnormal_larynx_morphology0.93523734
59MP0003879_abnormal_hair_cell0.92561722
60MP0003635_abnormal_synaptic_transmissio0.92216683
61MP0002277_abnormal_respiratory_mucosa0.87542019
62MP0010030_abnormal_orbit_morphology0.87394625
63MP0003115_abnormal_respiratory_system0.86502974
64MP0005394_taste/olfaction_phenotype0.86121528
65MP0005499_abnormal_olfactory_system0.86121528
66MP0000343_altered_response_to0.85840072
67MP0005646_abnormal_pituitary_gland0.85600093
68MP0005584_abnormal_enzyme/coenzyme_acti0.84144781
69MP0009765_abnormal_xenobiotic_induced0.83673504
70MP0002735_abnormal_chemical_nociception0.83170428
71MP0002752_abnormal_somatic_nervous0.80192357
72MP0002822_catalepsy0.79966844
73MP0000955_abnormal_spinal_cord0.79536054
74MP0008770_decreased_survivor_rate0.79022346
75MP0003137_abnormal_impulse_conducting0.78894529
76MP0003878_abnormal_ear_physiology0.78765175
77MP0005377_hearing/vestibular/ear_phenot0.78765175
78MP0002736_abnormal_nociception_after0.78415602
79MP0002882_abnormal_neuron_morphology0.77695219
80MP0003938_abnormal_ear_development0.77564702
81MP0000026_abnormal_inner_ear0.77168505
82MP0002138_abnormal_hepatobiliary_system0.75891416
83MP0002152_abnormal_brain_morphology0.74169838
84MP0008875_abnormal_xenobiotic_pharmacok0.73661279
85MP0003755_abnormal_palate_morphology0.73333197
86MP0002557_abnormal_social/conspecific_i0.72668373
87MP0002064_seizures0.72023194
88MP0002102_abnormal_ear_morphology0.71928220
89MP0002734_abnormal_mechanical_nocicepti0.71530208
90MP0002095_abnormal_skin_pigmentation0.70585434
91MP0009250_abnormal_appendicular_skeleto0.70220241
92MP0001486_abnormal_startle_reflex0.67111036
93MP0001986_abnormal_taste_sensitivity0.66103225
94MP0002116_abnormal_craniofacial_bone0.64176574
95MP0003698_abnormal_male_reproductive0.63704802
96MP0003890_abnormal_embryonic-extraembry0.62779206
97MP0005410_abnormal_fertilization0.62480508
98MP0006072_abnormal_retinal_apoptosis0.62169756
99MP0003880_abnormal_central_pattern0.61112471
100MP0006035_abnormal_mitochondrial_morpho0.60217773

Predicted human phenotypes

RankGene SetZ-score
1Retinal atrophy (HP:0001105)9.23969928
2Cerebellar dysplasia (HP:0007033)9.08320622
3Type II lissencephaly (HP:0007260)8.44220088
4Hypoplasia of the pons (HP:0012110)7.58999902
5Abnormality of the pons (HP:0007361)7.22357359
6Retinal dysplasia (HP:0007973)7.08342556
7Decreased electroretinogram (ERG) amplitude (HP:0000654)6.24223520
8Fatigue (HP:0012378)5.97871783
9Buphthalmos (HP:0000557)5.46810317
10Aplasia/Hypoplasia affecting the retina (HP:0008061)5.28550664
11Abolished electroretinogram (ERG) (HP:0000550)4.78770064
12Reticulocytopenia (HP:0001896)4.39451769
13Difficulty climbing stairs (HP:0003551)4.36315664
14Abnormality of midbrain morphology (HP:0002418)3.70530879
15Molar tooth sign on MRI (HP:0002419)3.70530879
16Entropion (HP:0000621)3.60471832
17Pallor (HP:0000980)3.49368889
18Abnormality of DNA repair (HP:0003254)3.49168143
19Severe muscular hypotonia (HP:0006829)3.46945925
20Generalized hypotonia (HP:0001290)3.36405177
21Megalocornea (HP:0000485)3.32375484
22Meningocele (HP:0002435)3.10944221
23Congenital glaucoma (HP:0001087)3.05688533
24Medial flaring of the eyebrow (HP:0010747)2.87225595
25Abnormality of cells of the erythroid lineage (HP:0012130)2.78476534
26Lissencephaly (HP:0001339)2.77743687
27Pachygyria (HP:0001302)2.77572708
28Pancreatic fibrosis (HP:0100732)2.76013881
29Poikiloderma (HP:0001029)2.74942672
30Hypoplasia of the brainstem (HP:0002365)2.73970817
31Aplasia/Hypoplasia of the brainstem (HP:0007362)2.73970817
32Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.51943990
33Severe global developmental delay (HP:0011344)2.47767478
34Absent/shortened dynein arms (HP:0200106)2.46859116
35Dynein arm defect of respiratory motile cilia (HP:0012255)2.46859116
36Nephronophthisis (HP:0000090)2.46676502
37Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.46421743
38Stenosis of the external auditory canal (HP:0000402)2.45961232
39Intellectual disability, profound (HP:0002187)2.45022114
40IgG deficiency (HP:0004315)2.35186116
41Abnormality of the vitreous humor (HP:0004327)2.35093668
42Holoprosencephaly (HP:0001360)2.32771281
43Non-midline cleft lip (HP:0100335)2.28220064
44Macrocytic anemia (HP:0001972)2.24351258
45Fragile nails (HP:0001808)2.22257909
46Acute necrotizing encephalopathy (HP:0006965)2.21476213
47Papilledema (HP:0001085)2.15241085
48Pancreatic cysts (HP:0001737)2.13267721
49Septo-optic dysplasia (HP:0100842)2.08634127
50Abnormal hemoglobin (HP:0011902)2.05675854
51Postaxial foot polydactyly (HP:0001830)2.04184198
52Erythroderma (HP:0001019)2.03600909
53Generalized muscle weakness (HP:0003324)2.02900410
54Decreased subcutaneous fat (HP:0001002)2.02790988
55Abnormal mitochondria in muscle tissue (HP:0008316)2.01261813
56Submucous cleft hard palate (HP:0000176)2.01069676
57Chronic hepatic failure (HP:0100626)1.99654993
58True hermaphroditism (HP:0010459)1.97170241
59Prominent metopic ridge (HP:0005487)1.95910936
60Cystic liver disease (HP:0006706)1.94837371
61Abnormal respiratory epithelium morphology (HP:0012253)1.94067225
62Abnormal respiratory motile cilium morphology (HP:0005938)1.94067225
63Sclerocornea (HP:0000647)1.92399937
64Abnormality of the metopic suture (HP:0005556)1.91888192
65Sacral dimple (HP:0000960)1.90305392
66Increased IgM level (HP:0003496)1.86664665
67Agitation (HP:0000713)1.83456793
68Dandy-Walker malformation (HP:0001305)1.81611118
69Mesangial abnormality (HP:0001966)1.80426645
70Rectal prolapse (HP:0002035)1.80379467
71Abnormality of the renal medulla (HP:0100957)1.76681210
72Omphalocele (HP:0001539)1.76322300
73Gowers sign (HP:0003391)1.75319846
74Acute encephalopathy (HP:0006846)1.75228724
75Intellectual disability, severe (HP:0010864)1.74989357
76Gait imbalance (HP:0002141)1.74894239
77Cortical visual impairment (HP:0100704)1.72020434
78Congenital primary aphakia (HP:0007707)1.64165814
79Polymicrogyria (HP:0002126)1.63449167
80Progressive macrocephaly (HP:0004481)1.60695507
81Colon cancer (HP:0003003)1.58283673
82Congenital ichthyosiform erythroderma (HP:0007431)1.58234308
83Abnormal ciliary motility (HP:0012262)1.58192998
84Mitochondrial inheritance (HP:0001427)1.57823943
85Absent thumb (HP:0009777)1.57625720
86Scrotal hypoplasia (HP:0000046)1.57535497
87Abnormal drinking behavior (HP:0030082)1.57213998
88Polydipsia (HP:0001959)1.57213998
89Synostosis of carpal bones (HP:0005048)1.54511652
90Iris coloboma (HP:0000612)1.52623499
91Abnormality of vision evoked potentials (HP:0000649)1.51734079
92Congenital hepatic fibrosis (HP:0002612)1.51625151
93Maternal diabetes (HP:0009800)1.51271957
94Optic nerve coloboma (HP:0000588)1.50551027
95Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.50536637
96Nephropathy (HP:0000112)1.50315817
97Anencephaly (HP:0002323)1.50224373
98Muscular dystrophy (HP:0003560)1.48836430
99Polyphagia (HP:0002591)1.48705855
100Focal motor seizures (HP:0011153)1.47804846

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK107.16447300
2MARK36.93650549
3STK112.95290829
4PIM12.82588051
5TXK2.79458049
6PTK2B2.46594010
7CAMKK22.46488658
8EPHB22.00627624
9CDK191.99464804
10ADRBK21.99040778
11NLK1.91895116
12WNK41.88951647
13DYRK21.84971105
14PRKCH1.77853655
15PIK3CA1.76912290
16NUAK11.64415950
17PRKD31.51327033
18MAP4K21.43955025
19GRK11.39374990
20LMTK21.27048364
21MAP3K111.24741446
22LRRK21.22460145
23MAP4K11.19213891
24TLK11.13676023
25TYRO31.09765749
26PINK11.07137671
27CSNK1G21.04252885
28PRKCQ1.00692748
29PAK30.96629143
30MAP2K20.94205798
31VRK20.92687276
32WNK10.91682613
33CAMK10.90162507
34CSNK1G10.89085356
35PLK20.88297835
36CAMKK10.86925627
37CSNK1G30.83642256
38PDK20.83568747
39MAP2K70.83007446
40FRK0.82744714
41PAK60.79223506
42TIE10.74382395
43NTRK20.74138199
44PRKCG0.72662446
45GSK3A0.71570571
46STK160.67699181
47VRK10.63201256
48MAPK130.60513853
49PKN10.60160230
50CAMK1D0.59719288
51GRK70.57866908
52ZAK0.57640823
53RPS6KA50.56520394
54INSRR0.55859422
55ADRBK10.53154085
56WNK30.52952813
57CSNK1A1L0.52715824
58DYRK1A0.52463817
59PRKCE0.51992447
60ERBB20.51836991
61TEC0.49621542
62KIT0.48971843
63OBSCN0.47902010
64IKBKB0.47743039
65PRKACA0.47022524
66CAMK2A0.46957840
67MAP3K40.46624052
68ITK0.45392512
69PRKCI0.45163163
70AKT20.43248989
71PRKCD0.42101056
72MINK10.41230474
73SGK10.40714438
74DAPK30.39925948
75PLK40.39548934
76KDR0.39363657
77CSNK1D0.38946293
78CASK0.38885538
79LCK0.38308047
80GRK50.36738045
81NEK10.36273826
82CSNK2A20.33144698
83CSNK1E0.32341418
84SGK4940.32322929
85SGK2230.32322929
86MARK10.32304984
87PIM20.31236120
88CSNK1A10.30075584
89PRKCA0.30049014
90PRKD20.29968489
91FYN0.29140204
92RPS6KA30.28866422
93SYK0.28866249
94ROCK10.28468104
95MAPK150.28148528
96BTK0.27856771
97RPS6KA60.27814694
98MAPK140.26668118
99LIMK10.25396561
100PRKCZ0.25334383

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.98015167
2Oxidative phosphorylation_Homo sapiens_hsa001903.64793793
3Other types of O-glycan biosynthesis_Homo sapiens_hsa005143.61906453
4Cardiac muscle contraction_Homo sapiens_hsa042603.21390707
5Parkinsons disease_Homo sapiens_hsa050122.78289562
6Sulfur relay system_Homo sapiens_hsa041222.64069165
7Alzheimers disease_Homo sapiens_hsa050102.22553698
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.17447839
9SNARE interactions in vesicular transport_Homo sapiens_hsa041302.14558313
10Huntingtons disease_Homo sapiens_hsa050162.14208048
11NOD-like receptor signaling pathway_Homo sapiens_hsa046211.91696214
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.89323697
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76081973
14Linoleic acid metabolism_Homo sapiens_hsa005911.59618516
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53986927
16Primary immunodeficiency_Homo sapiens_hsa053401.47172023
17Peroxisome_Homo sapiens_hsa041461.39329184
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.39197561
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38104435
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.35832927
21RNA polymerase_Homo sapiens_hsa030201.30999245
22Asthma_Homo sapiens_hsa053101.30106387
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28915953
24Graft-versus-host disease_Homo sapiens_hsa053321.24669002
25Insulin secretion_Homo sapiens_hsa049111.18036588
26Sulfur metabolism_Homo sapiens_hsa009201.16546982
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.09859244
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.08891358
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08455436
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08190227
31Fat digestion and absorption_Homo sapiens_hsa049751.03634750
32Fatty acid degradation_Homo sapiens_hsa000711.02424598
33Collecting duct acid secretion_Homo sapiens_hsa049661.01876126
34Nitrogen metabolism_Homo sapiens_hsa009101.01747132
35Nicotine addiction_Homo sapiens_hsa050331.00833564
36Steroid biosynthesis_Homo sapiens_hsa001001.00259030
37Autoimmune thyroid disease_Homo sapiens_hsa053200.90714086
38Allograft rejection_Homo sapiens_hsa053300.90191977
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85769432
40Ether lipid metabolism_Homo sapiens_hsa005650.83076437
41Regulation of autophagy_Homo sapiens_hsa041400.82873327
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82435451
43Glycerolipid metabolism_Homo sapiens_hsa005610.82289402
44Caffeine metabolism_Homo sapiens_hsa002320.81237876
45Leishmaniasis_Homo sapiens_hsa051400.80109797
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.79644708
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.77303502
48Retinol metabolism_Homo sapiens_hsa008300.76486050
49Morphine addiction_Homo sapiens_hsa050320.75329846
50Basal transcription factors_Homo sapiens_hsa030220.74646335
51Phototransduction_Homo sapiens_hsa047440.72659169
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72605539
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69517551
54RNA degradation_Homo sapiens_hsa030180.68008668
55Butanoate metabolism_Homo sapiens_hsa006500.67122700
56Olfactory transduction_Homo sapiens_hsa047400.66796310
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66035653
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65082361
59Glycosaminoglycan degradation_Homo sapiens_hsa005310.61924788
60Basal cell carcinoma_Homo sapiens_hsa052170.61866043
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61782195
62Tryptophan metabolism_Homo sapiens_hsa003800.61702125
63Chemical carcinogenesis_Homo sapiens_hsa052040.61514134
64Salivary secretion_Homo sapiens_hsa049700.59698579
65Homologous recombination_Homo sapiens_hsa034400.59129711
66Pyruvate metabolism_Homo sapiens_hsa006200.56406276
67Type I diabetes mellitus_Homo sapiens_hsa049400.55534927
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54099142
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53965152
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53352173
71Arachidonic acid metabolism_Homo sapiens_hsa005900.50151073
72Taste transduction_Homo sapiens_hsa047420.48031393
73Thyroid hormone synthesis_Homo sapiens_hsa049180.45792533
74Cholinergic synapse_Homo sapiens_hsa047250.44891023
75Dopaminergic synapse_Homo sapiens_hsa047280.44700170
76Fatty acid metabolism_Homo sapiens_hsa012120.44302714
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42973051
78Nucleotide excision repair_Homo sapiens_hsa034200.42352591
79Metabolic pathways_Homo sapiens_hsa011000.42327540
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42238248
81GABAergic synapse_Homo sapiens_hsa047270.41957761
82Serotonergic synapse_Homo sapiens_hsa047260.41487919
83TNF signaling pathway_Homo sapiens_hsa046680.39970382
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39721411
85Rheumatoid arthritis_Homo sapiens_hsa053230.39584753
86beta-Alanine metabolism_Homo sapiens_hsa004100.39482177
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39124136
88Starch and sucrose metabolism_Homo sapiens_hsa005000.38942804
89cAMP signaling pathway_Homo sapiens_hsa040240.38541871
90Bile secretion_Homo sapiens_hsa049760.38106822
91Mineral absorption_Homo sapiens_hsa049780.36344697
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.35704714
93Pancreatic secretion_Homo sapiens_hsa049720.35441810
94Ovarian steroidogenesis_Homo sapiens_hsa049130.34724309
95Ras signaling pathway_Homo sapiens_hsa040140.34403979
96Fanconi anemia pathway_Homo sapiens_hsa034600.34199073
97Antigen processing and presentation_Homo sapiens_hsa046120.33500504
98Cocaine addiction_Homo sapiens_hsa050300.32641549
99Proteasome_Homo sapiens_hsa030500.32066520
100MAPK signaling pathway_Homo sapiens_hsa040100.31006009

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