ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of regulatory T cell differentiation (GO:0045589)	5.12542604
2	regulation of isotype switching to IgG isotypes (GO:0048302)	5.05734580
3	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.86723934
4	DNA deamination (GO:0045006)	4.79607025
5	negative regulation of B cell apoptotic process (GO:0002903)	4.53234679
6	regulation of immunoglobulin secretion (GO:0051023)	4.27898470
7	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	4.27367110
8	behavioral response to nicotine (GO:0035095)	4.20258965
9	cellular response to exogenous dsRNA (GO:0071360)	4.14804404
10	sleep (GO:0030431)	3.93761766
11	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.87921990
12	L-fucose metabolic process (GO:0042354)	3.86751854
13	L-fucose catabolic process (GO:0042355)	3.86751854
14	fucose catabolic process (GO:0019317)	3.86751854
15	positive regulation of T cell differentiation in thymus (GO:0033089)	3.77473313
16	positive regulation of DNA recombination (GO:0045911)	3.70679205
17	positive regulation of isotype switching (GO:0045830)	3.70537149
18	response to xenobiotic stimulus (GO:0009410)	3.68516238
19	positive regulation of interleukin-17 production (GO:0032740)	3.59208844
20	regulation of B cell apoptotic process (GO:0002902)	3.44029427
21	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.41857961
22	positive regulation of prostaglandin secretion (GO:0032308)	3.39270475
23	positive regulation of fatty acid transport (GO:2000193)	3.36809608
24	piRNA metabolic process (GO:0034587)	3.21198128
25	regulation of gamma-delta T cell differentiation (GO:0045586)	3.16256925
26	adenosine metabolic process (GO:0046085)	3.15439938
27	cellular response to ATP (GO:0071318)	3.14604020
28	positive regulation of defense response to virus by host (GO:0002230)	3.12922625
29	S-adenosylmethionine metabolic process (GO:0046500)	3.12495421
30	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.10101901
31	termination of RNA polymerase III transcription (GO:0006386)	3.10101901
32	response to gravity (GO:0009629)	3.08227018
33	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.07659837
34	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.04125967
35	regulation of T cell mediated cytotoxicity (GO:0001914)	3.02332232
36	ATP synthesis coupled proton transport (GO:0015986)	3.02286358
37	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.02286358
38	negative regulation of T cell differentiation in thymus (GO:0033085)	3.01928248
39	protein-cofactor linkage (GO:0018065)	2.95907971
40	mast cell activation (GO:0045576)	2.95279315
41	mast cell degranulation (GO:0043303)	2.95228984
42	mast cell activation involved in immune response (GO:0002279)	2.95228984
43	regulation of isotype switching (GO:0045191)	2.93777109
44	ribosomal small subunit assembly (GO:0000028)	2.92845266
45	positive regulation of B cell mediated immunity (GO:0002714)	2.89864138
46	positive regulation of immunoglobulin mediated immune response (GO:0002891)	2.89864138
47	negative thymic T cell selection (GO:0045060)	2.89394100
48	negative T cell selection (GO:0043383)	2.87146553
49	positive thymic T cell selection (GO:0045059)	2.86730165
50	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.85246960
51	regulation of thymocyte apoptotic process (GO:0070243)	2.83825524
52	tolerance induction (GO:0002507)	2.83369992
53	platelet dense granule organization (GO:0060155)	2.82475462
54	positive regulation of icosanoid secretion (GO:0032305)	2.82291955
55	negative regulation of nitric oxide biosynthetic process (GO:0045019)	2.82215695
56	regulation of memory T cell differentiation (GO:0043380)	2.82148435
57	preassembly of GPI anchor in ER membrane (GO:0016254)	2.81642122
58	regulation of germinal center formation (GO:0002634)	2.81163244
59	regulation of T cell differentiation in thymus (GO:0033081)	2.78650126
60	water-soluble vitamin biosynthetic process (GO:0042364)	2.77343069
61	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.76670253
62	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.75584404
63	positive regulation of immunoglobulin production (GO:0002639)	2.75091282
64	regulation of immunoglobulin production (GO:0002637)	2.74584668
65	peptidyl-histidine modification (GO:0018202)	2.70649347
66	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.67878733
67	RNA destabilization (GO:0050779)	2.67783322
68	purine-containing compound salvage (GO:0043101)	2.66121376
69	regulation of T cell receptor signaling pathway (GO:0050856)	2.66095738
70	regulation of hypersensitivity (GO:0002883)	2.65835844
71	positive regulation of activated T cell proliferation (GO:0042104)	2.65674117
72	GMP metabolic process (GO:0046037)	2.65529056
73	mannosylation (GO:0097502)	2.62788401
74	cytidine metabolic process (GO:0046087)	2.60790022
75	cytidine catabolic process (GO:0006216)	2.60790022
76	cytidine deamination (GO:0009972)	2.60790022
77	interferon-gamma production (GO:0032609)	2.58382624
78	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.57169275
79	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.54613241
80	regulation of gamma-delta T cell activation (GO:0046643)	2.53937490
81	chaperone-mediated protein transport (GO:0072321)	2.52801559
82	purine nucleotide salvage (GO:0032261)	2.52676898
83	positive regulation of T-helper 1 type immune response (GO:0002827)	2.50924026
84	cellular response to interferon-beta (GO:0035458)	2.48557912
85	regulation of prostaglandin secretion (GO:0032306)	2.48219808
86	iron-sulfur cluster assembly (GO:0016226)	2.46734329
87	metallo-sulfur cluster assembly (GO:0031163)	2.46734329
88	regulation of cell killing (GO:0031341)	2.45259289
89	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.44879664
90	NADH dehydrogenase complex assembly (GO:0010257)	2.44879664
91	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.44879664
92	response to interferon-beta (GO:0035456)	2.44119940
93	tryptophan catabolic process (GO:0006569)	2.42719151
94	indole-containing compound catabolic process (GO:0042436)	2.42719151
95	indolalkylamine catabolic process (GO:0046218)	2.42719151
96	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	2.42518809
97	regulation of immunoglobulin mediated immune response (GO:0002889)	2.42203685
98	negative regulation of cell killing (GO:0031342)	2.42167248
99	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.42167248
100	auditory receptor cell stereocilium organization (GO:0060088)	2.42038522

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	4.34184514
2	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	3.28693745
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.83783423
4	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.75878337
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.74790996
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.66411897
7	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.59463737
8	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.56604649
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.53876256
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.49806914
11	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.49734965
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.45822930
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.41842024
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.38175451
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.32875254
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.26449009
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.26008163
18	GATA3_26560356_Chip-Seq_TH2_Human	2.19072683
19	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.18935168
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.13563359
21	RUNX_20019798_ChIP-Seq_JUKART_Human	2.12752635
22	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.05068240
23	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.02596592
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.94594247
25	VDR_22108803_ChIP-Seq_LS180_Human	1.74295854
26	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.73075571
27	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.70812627
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.69033797
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.65407022
30	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.65348422
31	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.62387576
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.61118278
33	MYB_26560356_Chip-Seq_TH2_Human	1.57851348
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.53363819
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.51952384
36	ELK1_19687146_ChIP-ChIP_HELA_Human	1.51782478
37	GATA3_27048872_Chip-Seq_THYMUS_Human	1.50544051
38	MYC_18940864_ChIP-ChIP_HL60_Human	1.48756510
39	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.45823079
40	AR_20517297_ChIP-Seq_VCAP_Human	1.42050891
41	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.40126166
42	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.39812614
43	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.39399545
44	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.38103777
45	ERA_21632823_ChIP-Seq_H3396_Human	1.37510648
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36201029
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36201029
48	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.35983206
49	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.35422579
50	IGF1R_20145208_ChIP-Seq_DFB_Human	1.34556109
51	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.31167810
52	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.29927255
53	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.28224143
54	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.27745638
55	TAF2_19829295_ChIP-Seq_ESCs_Human	1.26289102
56	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.22777135
57	CIITA_25753668_ChIP-Seq_RAJI_Human	1.22229532
58	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.18376224
59	HOXB7_26014856_ChIP-Seq_BT474_Human	1.17481305
60	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.16429480
61	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.14687688
62	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.12755657
63	ER_23166858_ChIP-Seq_MCF-7_Human	1.11929071
64	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.11724220
65	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.11170010
66	CBP_20019798_ChIP-Seq_JUKART_Human	1.11170010
67	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.11019705
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.09261164
69	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08539041
70	STAT1_20625510_ChIP-Seq_HELA_Human	1.07835027
71	P300_27268052_Chip-Seq_Bcells_Human	1.07746122
72	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07161623
73	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.07071948
74	IRF1_19129219_ChIP-ChIP_H3396_Human	1.06207637
75	RAC3_21632823_ChIP-Seq_H3396_Human	1.05966917
76	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.05889849
77	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.05171263
78	NCOR_22424771_ChIP-Seq_293T_Human	1.04460179
79	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.04246193
80	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.03976914
81	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03204503
82	BCL6_27268052_Chip-Seq_Bcells_Human	1.02650556
83	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02570044
84	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.01031838
85	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.00192015
86	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.99804966
87	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	0.99584967
88	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.98722814
89	NANOG_20526341_ChIP-Seq_ESCs_Human	0.98331260
90	FUS_26573619_Chip-Seq_HEK293_Human	0.98270332
91	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.97844781
92	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.97831365
93	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.97047195
94	MYB_26560356_Chip-Seq_TH1_Human	0.96964275
95	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.96729495
96	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.96101794
97	EWS_26573619_Chip-Seq_HEK293_Human	0.95799806
98	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.94628681
99	MYC_19829295_ChIP-Seq_ESCs_Human	0.94519533
100	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.94135157

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	3.66966048
2	MP0002138_abnormal_hepatobiliary_system	3.30800683
3	MP0005671_abnormal_response_to	2.98263662
4	MP0003724_increased_susceptibility_to	2.80654899
5	MP0004147_increased_porphyrin_level	2.68498793
6	MP0002148_abnormal_hypersensitivity_rea	2.48933584
7	MP0006072_abnormal_retinal_apoptosis	2.44337570
8	MP0000685_abnormal_immune_system	2.39998760
9	MP0001986_abnormal_taste_sensitivity	2.18731627
10	MP0005000_abnormal_immune_tolerance	2.13820543
11	MP0000372_irregular_coat_pigmentation	2.13590534
12	MP0003806_abnormal_nucleotide_metabolis	2.08561201
13	MP0005084_abnormal_gallbladder_morpholo	2.06102618
14	MP0008872_abnormal_physiological_respon	2.05695074
15	MP0003436_decreased_susceptibility_to	2.02556210
16	MP0005075_abnormal_melanosome_morpholog	2.02319226
17	MP0001800_abnormal_humoral_immune	2.00768932
18	MP0005646_abnormal_pituitary_gland	1.99865436
19	MP0008877_abnormal_DNA_methylation	1.97676396
20	MP0000569_abnormal_digit_pigmentation	1.89400584
21	MP0008875_abnormal_xenobiotic_pharmacok	1.89342007
22	MP0000465_gastrointestinal_hemorrhage	1.84388245
23	MP0001968_abnormal_touch/_nociception	1.81319760
24	MP0002723_abnormal_immune_serum	1.81009529
25	MP0002102_abnormal_ear_morphology	1.78626945
26	MP0003646_muscle_fatigue	1.72589863
27	MP0005387_immune_system_phenotype	1.67060093
28	MP0001790_abnormal_immune_system	1.67060093
29	MP0002166_altered_tumor_susceptibility	1.61159868
30	MP0005645_abnormal_hypothalamus_physiol	1.58754311
31	MP0001819_abnormal_immune_cell	1.56985971
32	MP0002420_abnormal_adaptive_immunity	1.55765744
33	MP0009764_decreased_sensitivity_to	1.55585785
34	MP0006292_abnormal_olfactory_placode	1.53951430
35	MP0002452_abnormal_antigen_presenting	1.51301832
36	MP0001853_heart_inflammation	1.50833473
37	MP0002006_tumorigenesis	1.43774834
38	MP0001440_abnormal_grooming_behavior	1.42297412
39	MP0003866_abnormal_defecation	1.41639987
40	MP0002736_abnormal_nociception_after	1.41063794
41	MP0004043_abnormal_pH_regulation	1.39144835
42	MP0004885_abnormal_endolymph	1.39142877
43	MP0003763_abnormal_thymus_physiology	1.36554996
44	MP0005670_abnormal_white_adipose	1.31347925
45	MP0006276_abnormal_autonomic_nervous	1.29856972
46	MP0009785_altered_susceptibility_to	1.28143053
47	MP0005025_abnormal_response_to	1.26211656
48	MP0004142_abnormal_muscle_tone	1.23181026
49	MP0003195_calcinosis	1.19489737
50	MP0005423_abnormal_somatic_nervous	1.19212498
51	MP0006036_abnormal_mitochondrial_physio	1.18913184
52	MP0002405_respiratory_system_inflammati	1.17614878
53	MP0001845_abnormal_inflammatory_respons	1.17169677
54	MP0005551_abnormal_eye_electrophysiolog	1.16427546
55	MP0005253_abnormal_eye_physiology	1.13786450
56	MP0002398_abnormal_bone_marrow	1.13551363
57	MP0003638_abnormal_response/metabolism_	1.12297420
58	MP0003252_abnormal_bile_duct	1.12109468
59	MP0008775_abnormal_heart_ventricle	1.11510768
60	MP0002876_abnormal_thyroid_physiology	1.10494481
61	MP0003878_abnormal_ear_physiology	1.08526195
62	MP0005377_hearing/vestibular/ear_phenot	1.08526195
63	MP0000689_abnormal_spleen_morphology	1.07977535
64	MP0002735_abnormal_chemical_nociception	1.07834109
65	MP0002638_abnormal_pupillary_reflex	1.05696430
66	MP0005167_abnormal_blood-brain_barrier	1.05674975
67	MP0000716_abnormal_immune_system	1.05406602
68	MP0001919_abnormal_reproductive_system	1.04790700
69	MP0002693_abnormal_pancreas_physiology	1.03219979
70	MP0010155_abnormal_intestine_physiology	1.00154673
71	MP0003011_delayed_dark_adaptation	0.99249521
72	MP0002163_abnormal_gland_morphology	0.98948444
73	MP0002733_abnormal_thermal_nociception	0.98655756
74	MP0003303_peritoneal_inflammation	0.97960754
75	MP0002272_abnormal_nervous_system	0.96805930
76	MP0002419_abnormal_innate_immunity	0.96189760
77	MP0000230_abnormal_systemic_arterial	0.95504442
78	MP0001502_abnormal_circadian_rhythm	0.93781603
79	MP0009745_abnormal_behavioral_response	0.92933754
80	MP0002722_abnormal_immune_system	0.92649495
81	MP0001905_abnormal_dopamine_level	0.91889048
82	MP0001501_abnormal_sleep_pattern	0.91333160
83	MP0006035_abnormal_mitochondrial_morpho	0.90150275
84	MP0001533_abnormal_skeleton_physiology	0.87527420
85	MP0005332_abnormal_amino_acid	0.87367674
86	MP0005464_abnormal_platelet_physiology	0.86375369
87	MP0002837_dystrophic_cardiac_calcinosis	0.86001739
88	MP0002429_abnormal_blood_cell	0.85672912
89	MP0005174_abnormal_tail_pigmentation	0.84890364
90	MP0005365_abnormal_bile_salt	0.84161871
91	MP0001970_abnormal_pain_threshold	0.81568589
92	MP0005389_reproductive_system_phenotype	0.81001040
93	MP0000703_abnormal_thymus_morphology	0.75310274
94	MP0001765_abnormal_ion_homeostasis	0.73545180
95	MP0008469_abnormal_protein_level	0.73531931
96	MP0000604_amyloidosis	0.72080552
97	MP0004947_skin_inflammation	0.71884640
98	MP0005085_abnormal_gallbladder_physiolo	0.71589238
99	MP0009333_abnormal_splenocyte_physiolog	0.69448712
100	MP0009046_muscle_twitch	0.67959974

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Stomatitis (HP:0010280)	4.82648002
2	IgG deficiency (HP:0004315)	4.13394263
3	Congenital, generalized hypertrichosis (HP:0004540)	3.93553236
4	Elevated erythrocyte sedimentation rate (HP:0003565)	3.65488409
5	3-Methylglutaconic aciduria (HP:0003535)	3.44477380
6	Congenital stationary night blindness (HP:0007642)	3.33006813
7	Pancreatic cysts (HP:0001737)	3.24149778
8	Myositis (HP:0100614)	3.19617735
9	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.08477542
10	Optic neuritis (HP:0100653)	2.92341722
11	Retrobulbar optic neuritis (HP:0100654)	2.92341722
12	Abolished electroretinogram (ERG) (HP:0000550)	2.86813919
13	Type II lissencephaly (HP:0007260)	2.86573810
14	Abnormality of the renal cortex (HP:0011035)	2.71123194
15	Acute necrotizing encephalopathy (HP:0006965)	2.68795852
16	Abnormality of B cell number (HP:0010975)	2.64931973
17	Abnormality of T cell physiology (HP:0011840)	2.63411384
18	Severe combined immunodeficiency (HP:0004430)	2.59642932
19	Stomach cancer (HP:0012126)	2.57710372
20	Renal cortical cysts (HP:0000803)	2.55109397
21	Type I transferrin isoform profile (HP:0003642)	2.53055945
22	Abnormality of eosinophils (HP:0001879)	2.52475152
23	Nephronophthisis (HP:0000090)	2.52130910
24	Acute encephalopathy (HP:0006846)	2.52078509
25	Abnormality of DNA repair (HP:0003254)	2.50915650
26	Increased IgM level (HP:0003496)	2.48809193
27	Prostate neoplasm (HP:0100787)	2.43048880
28	Thyroiditis (HP:0100646)	2.42350957
29	Delayed CNS myelination (HP:0002188)	2.41460802
30	Abnormal protein glycosylation (HP:0012346)	2.40701127
31	Abnormal glycosylation (HP:0012345)	2.40701127
32	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.40701127
33	Abnormal protein N-linked glycosylation (HP:0012347)	2.40701127
34	Hepatocellular necrosis (HP:0001404)	2.39864736
35	Mitochondrial inheritance (HP:0001427)	2.36775361
36	Progressive macrocephaly (HP:0004481)	2.36710669
37	Hepatic necrosis (HP:0002605)	2.33222132
38	Abnormal mitochondria in muscle tissue (HP:0008316)	2.32037585
39	Abnormality of midbrain morphology (HP:0002418)	2.30943505
40	Molar tooth sign on MRI (HP:0002419)	2.30943505
41	Pancreatic fibrosis (HP:0100732)	2.30738168
42	Orchitis (HP:0100796)	2.29172225
43	Increased CSF lactate (HP:0002490)	2.27834742
44	Absent thumb (HP:0009777)	2.27222049
45	Dry hair (HP:0011359)	2.26399025
46	Hypoproteinemia (HP:0003075)	2.24858715
47	IgM deficiency (HP:0002850)	2.24443136
48	Pustule (HP:0200039)	2.23614948
49	Methylmalonic acidemia (HP:0002912)	2.22866195
50	Fair hair (HP:0002286)	2.22513879
51	Constricted visual fields (HP:0001133)	2.22469474
52	Abnormal ciliary motility (HP:0012262)	2.18612843
53	Abnormal rod and cone electroretinograms (HP:0008323)	2.18359268
54	Abnormality of T cells (HP:0002843)	2.17553994
55	B lymphocytopenia (HP:0010976)	2.16990785
56	Neutropenia (HP:0001875)	2.16971186
57	Parakeratosis (HP:0001036)	2.16092150
58	Abnormality of the renal medulla (HP:0100957)	2.13678689
59	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.11393734
60	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.11393734
61	Panhypogammaglobulinemia (HP:0003139)	2.05690190
62	Eosinophilia (HP:0001880)	2.05563450
63	Pulmonary infiltrates (HP:0002113)	2.04767263
64	Mesangial abnormality (HP:0001966)	2.04419217
65	Hypomagnesemia (HP:0002917)	2.04270953
66	Type 2 muscle fiber atrophy (HP:0003554)	2.03768804
67	Progressive inability to walk (HP:0002505)	2.03556569
68	Abnormal biliary tract physiology (HP:0012439)	2.02804972
69	Bile duct proliferation (HP:0001408)	2.02804972
70	Lactic acidosis (HP:0003128)	1.98592819
71	Hypothermia (HP:0002045)	1.97361996
72	True hermaphroditism (HP:0010459)	1.97322629
73	Abnormality of the axillary hair (HP:0100134)	1.97098856
74	Abnormality of secondary sexual hair (HP:0009888)	1.97098856
75	Pachygyria (HP:0001302)	1.96496265
76	Brushfield spots (HP:0001088)	1.93794803
77	Attenuation of retinal blood vessels (HP:0007843)	1.92829500
78	Abnormality of the prostate (HP:0008775)	1.92613231
79	Conical tooth (HP:0000698)	1.92420897
80	Keratoconjunctivitis (HP:0001096)	1.92005129
81	Abnormality of dental color (HP:0011073)	1.91403527
82	Granulocytopenia (HP:0001913)	1.91124805
83	Progressive microcephaly (HP:0000253)	1.89975041
84	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.89822190
85	Retinal dysplasia (HP:0007973)	1.87513713
86	Methylmalonic aciduria (HP:0012120)	1.86925888
87	Combined immunodeficiency (HP:0005387)	1.85198912
88	Optic disc pallor (HP:0000543)	1.83655912
89	Increased serum lactate (HP:0002151)	1.82912153
90	Keratitis (HP:0000491)	1.82508414
91	Asplenia (HP:0001746)	1.81363628
92	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.77592993
93	Pendular nystagmus (HP:0012043)	1.76683454
94	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.75918478
95	Facial shape deformation (HP:0011334)	1.74846232
96	Potter facies (HP:0002009)	1.74846232
97	Alveolar cell carcinoma (HP:0006519)	1.73860171
98	Duplicated collecting system (HP:0000081)	1.73190153
99	Abnormality of the renal collecting system (HP:0004742)	1.73165405
100	Ketosis (HP:0001946)	1.71443930

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	3.50436646
2	FRK	3.17102694
3	TXK	2.93407781
4	TIE1	2.79017041
5	TAOK3	2.55381737
6	BCKDK	2.36016608
7	MAP4K1	2.29010692
8	NUAK1	2.20638425
9	MAP2K6	2.20603784
10	TLK1	2.19503080
11	MAP2K2	2.16259063
12	ADRBK2	2.15445234
13	WNK4	2.07557653
14	MAPKAPK3	2.04619059
15	CAMKK2	2.04455318
16	PINK1	2.03579549
17	TEC	1.97258151
18	IKBKB	1.95866480
19	ITK	1.94769423
20	GRK1	1.87583811
21	FES	1.81629162
22	MAP3K14	1.77656644
23	KIT	1.61065805
24	BMPR2	1.56077343
25	MAP4K2	1.54434448
26	CSNK1G3	1.51496076
27	CSNK1A1L	1.50009091
28	VRK2	1.47858614
29	PHKG1	1.36386358
30	PHKG2	1.36386358
31	FLT3	1.27579290
32	MST4	1.27451618
33	MUSK	1.24263080
34	NME1	1.22134118
35	DYRK2	1.20281351
36	CSNK1G2	1.18319867
37	PIK3CA	1.14695978
38	BMPR1B	1.14602342
39	CSNK1G1	1.13331682
40	IKBKE	1.12880930
41	GRK6	1.12757232
42	TBK1	1.05097243
43	ACVR1B	1.04238870
44	CAMKK1	1.04192424
45	SYK	1.02874996
46	LYN	1.01679442
47	OXSR1	0.97290985
48	PRKCQ	0.95928814
49	DAPK1	0.93500285
50	LCK	0.92132475
51	PLK2	0.91438458
52	TESK2	0.89480126
53	KDR	0.86351045
54	SRPK1	0.85917481
55	BTK	0.79240496
56	CSF1R	0.76023227
57	DAPK2	0.74289729
58	CHUK	0.73467623
59	GRK5	0.68093125
60	IGF1R	0.67837855
61	RIPK4	0.67430326
62	HIPK2	0.67359337
63	VRK1	0.63535360
64	HCK	0.61578919
65	STK39	0.61099064
66	ADRBK1	0.60806748
67	MAPK13	0.60616367
68	TRIM28	0.59702189
69	RPS6KA5	0.59395277
70	INSRR	0.59176551
71	JAK3	0.56636146
72	GRK7	0.56446958
73	MAPKAPK5	0.54627733
74	PLK4	0.54313179
75	EIF2AK2	0.54050643
76	CSK	0.53608486
77	ERBB3	0.52804278
78	PASK	0.50723599
79	PIK3CG	0.49538075
80	CDK8	0.47292877
81	EPHB1	0.46762215
82	PIM1	0.46745506
83	ATR	0.46414346
84	ERBB2	0.45851905
85	PRKCE	0.44086323
86	CSNK1D	0.39578664
87	PLK3	0.38914268
88	MATK	0.38513850
89	CSNK1A1	0.38196085
90	TNK2	0.37996786
91	PAK6	0.37043553
92	CDC7	0.35567206
93	RPS6KA6	0.35284666
94	RPS6KA1	0.34274539
95	ABL1	0.34270208
96	PRKCA	0.33786414
97	TRPM7	0.32266546
98	BRSK2	0.30098923
99	MAP3K11	0.28696256
100	PRKAA2	0.28603507

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.82433602
2	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.76166653
3	Graft-versus-host disease_Homo sapiens_hsa05332	3.71593516
4	Allograft rejection_Homo sapiens_hsa05330	3.45662439
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.17412038
6	Primary immunodeficiency_Homo sapiens_hsa05340	3.06624086
7	Type I diabetes mellitus_Homo sapiens_hsa04940	2.59811058
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.49049433
9	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.30757425
10	RNA polymerase_Homo sapiens_hsa03020	2.29653409
11	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.00210040
12	Oxidative phosphorylation_Homo sapiens_hsa00190	1.95833527
13	Antigen processing and presentation_Homo sapiens_hsa04612	1.94105223
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.85126641
15	Proteasome_Homo sapiens_hsa03050	1.81459786
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.81003914
17	Ribosome_Homo sapiens_hsa03010	1.77060867
18	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.72420252
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.69696597
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.59872370
21	Protein export_Homo sapiens_hsa03060	1.59368312
22	Phototransduction_Homo sapiens_hsa04744	1.45760797
23	Rheumatoid arthritis_Homo sapiens_hsa05323	1.42146982
24	Parkinsons disease_Homo sapiens_hsa05012	1.41020904
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.40243436
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.34261993
27	Homologous recombination_Homo sapiens_hsa03440	1.30485199
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.24848416
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.21362655
30	Regulation of autophagy_Homo sapiens_hsa04140	1.20678771
31	RNA degradation_Homo sapiens_hsa03018	1.18931019
32	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.16070109
33	Peroxisome_Homo sapiens_hsa04146	1.05876531
34	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.00790583
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.00533624
36	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.00350093
37	Caffeine metabolism_Homo sapiens_hsa00232	0.99890587
38	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.99812242
39	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.98883354
40	Pyrimidine metabolism_Homo sapiens_hsa00240	0.98504040
41	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.98012498
42	Selenocompound metabolism_Homo sapiens_hsa00450	0.97995035
43	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.94093531
44	Ether lipid metabolism_Homo sapiens_hsa00565	0.93166701
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.90761941
46	Purine metabolism_Homo sapiens_hsa00230	0.86258774
47	Tryptophan metabolism_Homo sapiens_hsa00380	0.84378972
48	Alzheimers disease_Homo sapiens_hsa05010	0.84135093
49	Cardiac muscle contraction_Homo sapiens_hsa04260	0.79666101
50	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.79170999
51	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.79133431
52	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.75794617
53	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.75718856
54	Propanoate metabolism_Homo sapiens_hsa00640	0.72681655
55	Leishmaniasis_Homo sapiens_hsa05140	0.72337982
56	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.71739429
57	Huntingtons disease_Homo sapiens_hsa05016	0.71635219
58	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.70140254
59	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.70019146
60	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.69693964
61	Nicotine addiction_Homo sapiens_hsa05033	0.68624271
62	Sulfur metabolism_Homo sapiens_hsa00920	0.68227430
63	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.67951976
64	Viral myocarditis_Homo sapiens_hsa05416	0.67474543
65	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.66526332
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.65189989
67	Chemical carcinogenesis_Homo sapiens_hsa05204	0.62757243
68	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.62479499
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.62422469
70	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.57028798
71	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.56677277
72	Base excision repair_Homo sapiens_hsa03410	0.55982687
73	Collecting duct acid secretion_Homo sapiens_hsa04966	0.55840589
74	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.55499731
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.54384571
76	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.52790248
77	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.48178933
78	Salivary secretion_Homo sapiens_hsa04970	0.48026945
79	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.46664053
80	Fatty acid elongation_Homo sapiens_hsa00062	0.45577218
81	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.44076532
82	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.41819104
83	Metabolic pathways_Homo sapiens_hsa01100	0.39074751
84	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.38274583
85	Olfactory transduction_Homo sapiens_hsa04740	0.37235205
86	One carbon pool by folate_Homo sapiens_hsa00670	0.35886503
87	Taste transduction_Homo sapiens_hsa04742	0.35793467
88	Morphine addiction_Homo sapiens_hsa05032	0.35489313
89	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.34836405
90	Spliceosome_Homo sapiens_hsa03040	0.34763146
91	Retinol metabolism_Homo sapiens_hsa00830	0.34574782
92	Basal transcription factors_Homo sapiens_hsa03022	0.34433081
93	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.33424555
94	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.31698481
95	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.31437420
96	Butanoate metabolism_Homo sapiens_hsa00650	0.29535016
97	Legionellosis_Homo sapiens_hsa05134	0.28589354
98	Glycerolipid metabolism_Homo sapiens_hsa00561	0.27492535
99	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.25502743
100	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.24660605

RPL31P33

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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